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<meta name="keywords" content="C0238198, gant, gastrointestinal pacemaker cell tumor, gastrointestinal stroma tumor, gastrointestinal stroma tumour, gastrointestinal stromal neoplasm, gastrointestinal stromal neoplasms, gastrointestinal stromal sarcoma, gastrointestinal stromal tumor, gastrointestinal stromal tumor (gist), gastrointestinal stromal tumor, familial, isolated cases, gastrointestinal stromal tumor, isolated cases, gastrointestinal stromal tumor, somatic, gastrointestinal stromal tumors, gastrointestinal stromal tumour, gastrointestinal stromal tumour (gist), gastrointestinal stromal tumours, gi stroma tumor, gi stroma tumour, gist, gist - gastrointestinal stromal tumor, kit, neoplasm, gastrointestinal stromal, neoplasms, gastrointestinal stromal, neoplastic process, sdhb, sdhc, stromal neoplasm, gastrointestinal, stromal neoplasms, gastrointestinal, stromal tumor of gastrointestinal tract, stromal tumor, gastrointestinal, stromal tumors, gastrointestinal, stromal tumour of gastrointestinal tract, tumor, gastrointestinal stromal, tumors, gastrointestinal stromal, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors found in the gastrointestinal tract that originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract. Approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum. GISTs are typically more cellular than other gastrointestinal sarcomas. They occur predominantly in patients who are 40 to 70 years old but in rare cases may occur in younger persons (Miettinen et al., 1999, 1999). GISTs are also seen as a feature in several syndromes, e.g., neurofibromatosis-1 (NF1; 162200) and GIST-plus syndrome (175510)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=116049
|
||
ConceptID=C0238198
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Gastrointestinal stromal tumor<span class="h1sub">(GIST)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>116049</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0238198</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Gastrointestinal stroma tumor; Gastrointestinal Stromal Sarcoma; Gastrointestinal stromal tumor, somatic</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Gastrointestinal pacemaker cell tumor (128755003); Gastrointestinal stromal tumor (420120006); GIST - Gastrointestinal stromal tumor (420120006); Gastrointestinal stromal tumor (1187383001)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_141047"><div><strong>Autosomal dominant inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141047</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0443147</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Intellectual Product</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.</div></div>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant inheritance</a><span> (Orphanet)</span></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="KIT - ID: 3815 - NCBI Gene" href="/gene/3815" class="medgenPMinfo">KIT</a> (4q12); <a target="_blank" title="SDHB - ID: 6390 - NCBI Gene" href="/gene/6390" class="medgenPMinfo">SDHB</a> (1p36.13); <a target="_blank" title="SDHC - ID: 6391 - NCBI Gene" href="/gene/6391" class="medgenPMinfo">SDHC</a> (1q23.3)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100723">HP:0100723</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0011719" target="_blank">MONDO:0011719</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/606764" target="_blank">606764</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=44890">ORPHA44890</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors found in the gastrointestinal tract that originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract. Approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum. GISTs are typically more cellular than other gastrointestinal sarcomas. They occur predominantly in patients who are 40 to 70 years old but in rare cases may occur in younger persons (Miettinen et al., 1999, 1999). GISTs are also seen as a feature in several syndromes, e.g., neurofibromatosis-1 (NF1; 162200) and GIST-plus syndrome (175510). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. This type of tumor is thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. Affected individuals can develop one or more tumors. GISTs are usually found in adults between ages 40 and 70; rarely, children and young adults develop this type of tumor. <br /><br />Small tumors may cause no signs or symptoms. However, some people with GISTs may experience pain or swelling in the belly area (abdomen), nausea, vomiting, loss of appetite, or weight loss. Sometimes, tumors cause bleeding into the gastrointestinal tract, which may lead to low red blood cell counts (anemia) and, consequently, weakness and tiredness. Bleeding into the intestines may cause black and tarry stools, and bleeding into the throat or stomach may cause vomiting of blood.<br /><br />Affected individuals with no family history of GIST typically have only one tumor (called a sporadic GIST). People with a family history of GISTs (called familial GISTs) often have multiple tumors and additional signs or symptoms, including noncancerous overgrowth (hyperplasia) of other cells in the gastrointestinal tract and patches of dark skin on various areas of the body. Some affected individuals have a skin condition called urticaria pigmentosa (also known as maculopapular cutaneous mastocytosis), which is characterized by raised patches of brownish skin that sting or itch when touched.<br /><br />A rare form of GIST, called succinate dehydrogenase (SDH)-deficient GIST, tends to occur in childhood or young adulthood and affects females more commonly than males. In this form, tumors are almost always in the stomach. Individuals with an SDH-deficient GIST have a high risk of developing other types of tumors, particularly noncancerous tumors in the nervous system called paragangliomas and noncancerous lung tumors called pulmonary chondromas. When GISTs occur in combination with paragangliomas, the condition is known as Carney-Stratakis syndrome; the combination of GISTs, paragangliomas, and pulmonary chondromas is known as Carney triad; and the combination of GISTs and pulmonary chondroma is known as incomplete Carney triad. <a target="_blank" href="https://medlineplus.gov/genetics/condition/gastrointestinal-stromal-tumor">https://medlineplus.gov/genetics/condition/gastrointestinal-stromal-tumor</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_98097"><div><strong>Large hands</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98097</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0426870</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/98097">Feature record</a> | <a href="/medgen?term=%22Large%20hands%22%5BClinical%20Features%5D%20OR%2098097%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1101"><div><strong>Constipation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1101</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0009806</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Infrequent or difficult evacuation of feces.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1101">Feature record</a> | <a href="/medgen?term=%22Constipation%22%5BClinical%20Features%5D%20OR%201101%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_41440"><div><strong>Dysphagia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41440</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0011168</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Difficulty in swallowing.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/41440">Feature record</a> | <a href="/medgen?term=%22Dysphagia%22%5BClinical%20Features%5D%20OR%2041440%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_43933"><div><strong>Intestinal obstruction</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>43933</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0021843</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/43933">Feature record</a> | <a href="/medgen?term=%22Intestinal%20obstruction%22%5BClinical%20Features%5D%20OR%2043933%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_116049"><div><strong>Gastrointestinal stromal tumor</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>116049</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0238198</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors found in the gastrointestinal tract that originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract. Approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum. GISTs are typically more cellular than other gastrointestinal sarcomas. They occur predominantly in patients who are 40 to 70 years old but in rare cases may occur in younger persons (Miettinen et al., 1999, 1999). GISTs are also seen as a feature in several syndromes, e.g., neurofibromatosis-1 (NF1; 162200) and GIST-plus syndrome (175510).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/116049">Feature record</a> | <a href="/medgen?term=%22Gastrointestinal%20stromal%20tumor%22%5BClinical%20Features%5D%20OR%20116049%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_45058"><div><strong>Neurofibroma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45058</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0027830</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A benign peripheral nerve sheath tumor that generally appears as a soft, skin-colored papule or small subcutaneous nodule. Individuals with neurofibromatosis can have numerous neurofibromas.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/45058">Feature record</a> | <a href="/medgen?term=%22Neurofibroma%22%5BClinical%20Features%5D%20OR%2045058%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_22587"><div><strong>Urticaria</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>22587</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0042109</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/22587">Feature record</a> | <a href="/medgen?term=%22Urticaria%22%5BClinical%20Features%5D%20OR%2022587%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_57992"><div><strong>Hyperpigmentation of the skin</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57992</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0162834</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A darkening of the skin related to an increase in melanin production and deposition.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/57992">Feature record</a> | <a href="/medgen?term=%22Hyperpigmentation%20of%20the%20skin%22%5BClinical%20Features%5D%20OR%2057992%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of limbs</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_98097" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Large hands</a></span></li></ul></li><li><span class="TLline">Abnormality of the digestive system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1101" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Constipation</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_41440" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dysphagia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_116049" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastrointestinal stromal tumor</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_43933" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intestinal obstruction</a></span></li></ul></li><li><span class="TLline">Abnormality of the integument</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57992" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperpigmentation of the skin</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_22587" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Urticaria</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_45058" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurofibroma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0238198[DISCUI]&test_type=Clinical" ref="ncbi_uid=116049">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=116049" target="_blank" href="/omim/185470">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=116049" ref="ncbi_uid=116049">V</a></span></span><span class="TLline">Gastrointestinal stromal tumor</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/272508" ref="tree=MeSH" title="MedGen record for Connective and Soft Tissue Disorder">Connective and Soft Tissue Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/60224" ref="tree=MeSH" title="MedGen record for Connective and soft tissue neoplasm">Connective and soft tissue neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/45035" ref="tree=MeSH" title="MedGen record for Connective tissue neoplasm">Connective tissue neoplasm</a></span><ul><li><span class="matched_ds">Gastrointestinal stromal tumor</span><ul><li><span class="TLline"><a href="/medgen/473367" ref="tree=MeSH" title="MedGen record for Benign Gastrointestinal Stromal Tumor">Benign Gastrointestinal Stromal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/474052" ref="tree=MeSH" title="MedGen record for Benign Gastric Gastrointestinal Stromal Tumor">Benign Gastric Gastrointestinal Stromal Tumor</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/906937" ref="tree=MeSH" title="MedGen record for Childhood Gastrointestinal Stromal Tumor">Childhood Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/43353" ref="tree=MeSH" title="MedGen record for Epithelioid Cell Type Gastrointestinal Stromal Tumor">Epithelioid Cell Type Gastrointestinal Stromal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/443061" ref="tree=MeSH" title="MedGen record for Benign Epithelioid Cell Type Gastrointestinal Stromal Tumor">Benign Epithelioid Cell Type Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/415168" ref="tree=MeSH" title="MedGen record for Malignant Epithelioid Cell Type Gastrointestinal Stromal Tumor">Malignant Epithelioid Cell Type Gastrointestinal Stromal Tumor</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234242" ref="tree=MeSH" title="MedGen record for Extragastrointestinal Gastrointestinal Stromal Tumor">Extragastrointestinal Gastrointestinal Stromal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/275363" ref="tree=MeSH" title="MedGen record for Peritoneal Gastrointestinal Stromal Tumor">Peritoneal Gastrointestinal Stromal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/269194" ref="tree=MeSH" title="MedGen record for Mesenteric Gastrointestinal Stromal Tumor">Mesenteric Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/309475" ref="tree=MeSH" title="MedGen record for Omentum Gastrointestinal Stromal Tumor">Omentum Gastrointestinal Stromal Tumor</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/271680" ref="tree=MeSH" title="MedGen record for Retroperitoneal Gastrointestinal Stromal Tumor">Retroperitoneal Gastrointestinal Stromal Tumor</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232555" ref="tree=MeSH" title="MedGen record for Gastrointestinal Stromal Tumor of the Gastrointestinal Tract">Gastrointestinal Stromal Tumor of the Gastrointestinal Tract</a></span><ul><li><span class="TLline"><a href="/medgen/272496" ref="tree=MeSH" title="MedGen record for Colorectal gastrointestinal stromal tumor">Colorectal gastrointestinal stromal tumor</a></span></li><li><span class="TLline"><a href="/medgen/232159" ref="tree=MeSH" title="MedGen record for Esophageal Gastrointestinal Stromal Tumor">Esophageal Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/232231" ref="tree=MeSH" title="MedGen record for Gastric Gastrointestinal Stromal Tumor">Gastric Gastrointestinal Stromal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/474055" ref="tree=MeSH" title="MedGen record for Gastric Gastrointestinal Stromal Tumor of Uncertain Malignant Potential">Gastric Gastrointestinal Stromal Tumor of Uncertain Malignant Potential</a></span></li><li><span class="TLline"><a href="/medgen/474054" ref="tree=MeSH" title="MedGen record for Gastric Malignant Gastrointestinal Stromal Tumor">Gastric Malignant Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453636" ref="tree=MeSH" title="MedGen record for Stage IA Gastric Gastrointestinal Stromal Tumor">Stage IA Gastric Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453637" ref="tree=MeSH" title="MedGen record for Stage IB Gastric Gastrointestinal Stromal Tumor">Stage IB Gastric Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453638" ref="tree=MeSH" title="MedGen record for Stage II Gastric Gastrointestinal Stromal Tumor">Stage II Gastric Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453639" ref="tree=MeSH" title="MedGen record for Stage IIIA Gastric Gastrointestinal Stromal Tumor">Stage IIIA Gastric Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453640" ref="tree=MeSH" title="MedGen record for Stage IIIB Gastric Gastrointestinal Stromal Tumor">Stage IIIB Gastric Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453641" ref="tree=MeSH" title="MedGen record for Stage IV Gastric Gastrointestinal Stromal Tumor">Stage IV Gastric Gastrointestinal Stromal Tumor</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234790" ref="tree=MeSH" title="MedGen record for Gastrointestinal stromal tumor of small intestine">Gastrointestinal stromal tumor of small intestine</a></span><ul><li><span class="TLline"><a href="/medgen/453642" ref="tree=MeSH" title="MedGen record for Stage I Small Intestinal Gastrointestinal Stromal Tumor">Stage I Small Intestinal Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453643" ref="tree=MeSH" title="MedGen record for Stage II Small Intestinal Gastrointestinal Stromal Tumor">Stage II Small Intestinal Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453644" ref="tree=MeSH" title="MedGen record for Stage IIIA Small Intestinal Gastrointestinal Stromal Tumor">Stage IIIA Small Intestinal Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453645" ref="tree=MeSH" title="MedGen record for Stage IIIB Small Intestinal Gastrointestinal Stromal Tumor">Stage IIIB Small Intestinal Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/453646" ref="tree=MeSH" title="MedGen record for Stage IV Small Intestinal Gastrointestinal Stromal Tumor">Stage IV Small Intestinal Gastrointestinal Stromal Tumor</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/312388" ref="tree=MeSH" title="MedGen record for Gastrointestinal Stromal Tumor of Uncertain Malignant Potential">Gastrointestinal Stromal Tumor of Uncertain Malignant Potential</a></span></li><li><span class="TLline"><a href="/medgen/465816" ref="tree=MeSH" title="MedGen record for Malignant Gastrointestinal Stromal Tumor">Malignant Gastrointestinal Stromal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/1792396" ref="tree=MeSH" title="MedGen record for Dedifferentiated Gastrointestinal Stromal Tumor">Dedifferentiated Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/1612744" ref="tree=MeSH" title="MedGen record for Gastrointestinal Stromal Tumor by AJCC v8 Stage">Gastrointestinal Stromal Tumor by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1625349" ref="tree=MeSH" title="MedGen record for Gastric and Omental Gastrointestinal Stromal Tumor by AJCC v8 Stage">Gastric and Omental Gastrointestinal Stromal Tumor by AJCC v8 Stage</a></span></li><li><span class="TLline"><a href="/medgen/1627794" ref="tree=MeSH" title="MedGen record for Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor by AJCC v8 Stage">Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor by AJCC v8 Stage</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1659379" ref="tree=MeSH" title="MedGen record for Metastatic Gastrointestinal Stromal Tumor">Metastatic Gastrointestinal Stromal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/1774461" ref="tree=MeSH" title="MedGen record for Advanced Gastrointestinal Stromal Tumor">Advanced Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/1666879" ref="tree=MeSH" title="MedGen record for Locally Advanced Gastrointestinal Stromal Tumor">Locally Advanced Gastrointestinal Stromal Tumor</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1670607" ref="tree=MeSH" title="MedGen record for Unresectable Malignant Gastrointestinal Stromal Tumor">Unresectable Malignant Gastrointestinal Stromal Tumor</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/277376" ref="tree=MeSH" title="MedGen record for Mixed Cell Type Gastrointestinal Stromal Tumor">Mixed Cell Type Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/925838" ref="tree=MeSH" title="MedGen record for Recurrent Gastrointestinal Stromal Tumor">Recurrent Gastrointestinal Stromal Tumor</a></span></li><li><span class="TLline"><a href="/medgen/236840" ref="tree=MeSH" title="MedGen record for Spindle Cell Type Gastrointestinal Stromal Tumor">Spindle Cell Type Gastrointestinal Stromal Tumor</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=10584&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Gastrointestinal stromal tumor</span> in Orphanet.</div></div></div>
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||
</div>
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||
|
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<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_116049"><div><strong>Gastrointestinal stromal tumor</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>116049</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0238198</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors found in the gastrointestinal tract that originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract. Approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum. GISTs are typically more cellular than other gastrointestinal sarcomas. They occur predominantly in patients who are 40 to 70 years old but in rare cases may occur in younger persons (Miettinen et al., 1999, 1999). GISTs are also seen as a feature in several syndromes, e.g., neurofibromatosis-1 (NF1; 162200) and GIST-plus syndrome (175510).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/116049">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_349380"><div><strong>Paragangliomas 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349380</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1861848</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hereditary paraganglioma-pheochromocytoma (PGL/PCC) syndromes are characterized by paragangliomas (tumors that arise from neuroendocrine tissues distributed along the paravertebral axis from the base of the skull to the pelvis) and pheochromocytomas (paragangliomas that are confined to the adrenal medulla). Sympathetic paragangliomas cause catecholamine excess; parasympathetic paragangliomas are most often nonsecretory. Extra-adrenal parasympathetic paragangliomas are located predominantly in the skull base and neck (referred to as head and neck paragangliomas [HNPGLs]) and sometimes in the upper mediastinum; approximately 95% of such tumors are nonsecretory. In contrast, extra-adrenal sympathetic paragangliomas are generally confined to the lower mediastinum, abdomen, and pelvis, and are typically secretory. Pheochromocytomas, which arise from the adrenal medulla, typically lead to catecholamine excess. Symptoms of PGL/PCCs result from either mass effects or catecholamine hypersecretion (e.g., sustained or paroxysmal elevations in blood pressure, headache, episodic profuse sweating, forceful palpitations, pallor, and apprehension or anxiety). The risk for developing metastatic disease is greater for extra-adrenal sympathetic paragangliomas than for pheochromocytomas. Additional tumors reported in individuals with hereditary PGL/PCC syndromes include gastrointestinal stromal tumors (GISTs), pulmonary chondromas, and clear cell renal cell carcinoma.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/349380">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1677803"><div><strong>Polyps, multiple and recurrent inflammatory fibroid, gastrointestinal</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1677803</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193005</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">GIST-plus syndrome (GISTPS) is an autosomal dominant disorder characterized by incomplete penetrance of multiple mesenchymal tumors of the gastrointestinal tract, including gastrointestinal stromal tumor (GIST), inflammatory fibroid polyps (IFP), and fibroid tumors (FT). Some patients have been reported with coarse facies and skin, broad hands and feet, and premature tooth loss. Isolated GISTs and IFPs are seen in patients with somatic PDGFRA mutations (summary by Manley et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1677803">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_116049" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastrointestinal stromal tumor</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_349380" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Paragangliomas 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1677803" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polyps, multiple and recurrent inflammatory fibroid, gastrointestinal</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35180797">Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Deprez PH,
|
||
Moons LMG,
|
||
OʼToole D,
|
||
Gincul R,
|
||
Seicean A,
|
||
Pimentel-Nunes P,
|
||
Fernández-Esparrach G,
|
||
Polkowski M,
|
||
Vieth M,
|
||
Borbath I,
|
||
Moreels TG,
|
||
Nieveen van Dijkum E,
|
||
Blay JY,
|
||
van Hooft JE</span><br />
|
||
<span class="medgenPMjournal">Endoscopy</span>
|
||
2022 Apr;54(4):412-429.
|
||
Epub 2022 Feb 18
|
||
doi: 10.1055/a-1751-5742.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35180797" target="_blank">35180797</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33402214">The management of metastatic GIST: current standard and investigational therapeutics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kelly CM,
|
||
Gutierrez Sainz L,
|
||
Chi P</span><br />
|
||
<span class="medgenPMjournal">J Hematol Oncol</span>
|
||
2021 Jan 5;14(1):2.
|
||
doi: 10.1186/s13045-020-01026-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33402214" target="_blank">33402214</a><a href="/pmc/articles/PMC7786896" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30018476">Current clinical management of gastrointestinal stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Akahoshi K,
|
||
Oya M,
|
||
Koga T,
|
||
Shiratsuchi Y</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2018 Jul 14;24(26):2806-2817.
|
||
doi: 10.3748/wjg.v24.i26.2806.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30018476" target="_blank">30018476</a><a href="/pmc/articles/PMC6048423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22gastrointestinal%20stromal%20tumor%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (244)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/gist.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastrointestinal Stromal Tumors, 2023</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32773198">Diagnoses and Difficulties in Mesenteric Pathology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dashti NK,
|
||
Shi C</span><br />
|
||
<span class="medgenPMjournal">Surg Pathol Clin</span>
|
||
2020 Sep;13(3):521-556.
|
||
Epub 2020 Jul 15
|
||
doi: 10.1016/j.path.2020.06.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32773198" target="_blank">32773198</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28325196">Management of Gastrointestinal Stromal Tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Keung EZ,
|
||
Raut CP</span><br />
|
||
<span class="medgenPMjournal">Surg Clin North Am</span>
|
||
2017 Apr;97(2):437-452.
|
||
doi: 10.1016/j.suc.2016.12.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28325196" target="_blank">28325196</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28096720">Update on Gastrointestinal Stromal Tumors for Radiologists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tirumani SH,
|
||
Baheti AD,
|
||
Tirumani H,
|
||
O'Neill A,
|
||
Jagannathan JP</span><br />
|
||
<span class="medgenPMjournal">Korean J Radiol</span>
|
||
2017 Jan-Feb;18(1):84-93.
|
||
Epub 2017 Jan 5
|
||
doi: 10.3348/kjr.2017.18.1.84.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28096720" target="_blank">28096720</a><a href="/pmc/articles/PMC5240484" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27546844">Knowns and Known Unknowns of Gastrointestinal Stromal Tumor Adjuvant Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martínez-Marín V,
|
||
Maki RG</span><br />
|
||
<span class="medgenPMjournal">Gastroenterol Clin North Am</span>
|
||
2016 Sep;45(3):477-86.
|
||
doi: 10.1016/j.gtc.2016.04.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27546844" target="_blank">27546844</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27166665">Targeted treatments of sarcomas and connective tumors beside gastrointestinal stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martin-Broto J,
|
||
Hindi N</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Oncol</span>
|
||
2016 Jul;28(4):338-44.
|
||
doi: 10.1097/CCO.0000000000000302.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27166665" target="_blank">27166665</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastrointestinal%20stromal%20tumor%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1375)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37195885">Pediatric Gastrointestinal Stromal Tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dembiński Ł,
|
||
Dziekiewicz M,
|
||
Banasiuk M,
|
||
Banaszkiewicz A</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Gastroenterol Nutr</span>
|
||
2023 Aug 1;77(2):e48.
|
||
Epub 2023 May 17
|
||
doi: 10.1097/MPG.0000000000003831.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37195885" target="_blank">37195885</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36309865">Gastrointestinal Stromal Tumor of the Appendix.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Elnassasra A,
|
||
Hershkovitz Y,
|
||
Zager Y,
|
||
Lavy R</span><br />
|
||
<span class="medgenPMjournal">Isr Med Assoc J</span>
|
||
2022 Oct;24(10):677-678.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36309865" target="_blank">36309865</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30018476">Current clinical management of gastrointestinal stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Akahoshi K,
|
||
Oya M,
|
||
Koga T,
|
||
Shiratsuchi Y</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2018 Jul 14;24(26):2806-2817.
|
||
doi: 10.3748/wjg.v24.i26.2806.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30018476" target="_blank">30018476</a><a href="/pmc/articles/PMC6048423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28750384">Gastrointestinal Stromal Tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Domansk HA,
|
||
Walther CS</span><br />
|
||
<span class="medgenPMjournal">Monogr Clin Cytol</span>
|
||
2017;22:89-91.
|
||
Epub 2017 Jul 27
|
||
doi: 10.1159/000475100.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28750384" target="_blank">28750384</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28632504">What is New in Gastrointestinal Stromal Tumor?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schaefer IM,
|
||
Mariño-Enríquez A,
|
||
Fletcher JA</span><br />
|
||
<span class="medgenPMjournal">Adv Anat Pathol</span>
|
||
2017 Sep;24(5):259-267.
|
||
doi: 10.1097/PAP.0000000000000158.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28632504" target="_blank">28632504</a><a href="/pmc/articles/PMC5608028" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastrointestinal%20stromal%20tumor%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1882)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35522913">The GIST of Advances in Treatment of Advanced Gastrointestinal Stromal Tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schaefer IM,
|
||
DeMatteo RP,
|
||
Serrano C</span><br />
|
||
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
|
||
2022 Apr;42:1-15.
|
||
doi: 10.1200/EDBK_351231.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35522913" target="_blank">35522913</a><a href="/pmc/articles/PMC9113521" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33402214">The management of metastatic GIST: current standard and investigational therapeutics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kelly CM,
|
||
Gutierrez Sainz L,
|
||
Chi P</span><br />
|
||
<span class="medgenPMjournal">J Hematol Oncol</span>
|
||
2021 Jan 5;14(1):2.
|
||
doi: 10.1186/s13045-020-01026-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33402214" target="_blank">33402214</a><a href="/pmc/articles/PMC7786896" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30914028">Mutational Testing in Gastrointestinal Stromal Tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang Y,
|
||
Call J</span><br />
|
||
<span class="medgenPMjournal">Curr Cancer Drug Targets</span>
|
||
2019;19(9):688-697.
|
||
doi: 10.2174/1568009619666190326123945.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30914028" target="_blank">30914028</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30018476">Current clinical management of gastrointestinal stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Akahoshi K,
|
||
Oya M,
|
||
Koga T,
|
||
Shiratsuchi Y</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2018 Jul 14;24(26):2806-2817.
|
||
doi: 10.3748/wjg.v24.i26.2806.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30018476" target="_blank">30018476</a><a href="/pmc/articles/PMC6048423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28325196">Management of Gastrointestinal Stromal Tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Keung EZ,
|
||
Raut CP</span><br />
|
||
<span class="medgenPMjournal">Surg Clin North Am</span>
|
||
2017 Apr;97(2):437-452.
|
||
doi: 10.1016/j.suc.2016.12.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28325196" target="_blank">28325196</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastrointestinal%20stromal%20tumor%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1182)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31100757">Treatment Options for Metastatic Gastrointestinal Stromal Tumors to the Liver: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lillemoe HA,
|
||
Brudvik KW,
|
||
Vauthey JN</span><br />
|
||
<span class="medgenPMjournal">Semin Liver Dis</span>
|
||
2019 Jul;39(3):395-402.
|
||
Epub 2019 May 17
|
||
doi: 10.1055/s-0039-1685517.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31100757" target="_blank">31100757</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30018476">Current clinical management of gastrointestinal stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Akahoshi K,
|
||
Oya M,
|
||
Koga T,
|
||
Shiratsuchi Y</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2018 Jul 14;24(26):2806-2817.
|
||
doi: 10.3748/wjg.v24.i26.2806.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30018476" target="_blank">30018476</a><a href="/pmc/articles/PMC6048423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29658644">Current status and future perspectives of endoscopic full-thickness resection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mori H,
|
||
Kobara H,
|
||
Nishiyama N,
|
||
Masaki T</span><br />
|
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<span class="medgenPMjournal">Dig Endosc</span>
|
||
2018 Apr;30 Suppl 1:25-31.
|
||
doi: 10.1111/den.13042.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29658644" target="_blank">29658644</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28655409">Concurrent inflammatory bowel disease and gastrointestinal stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Agud Fernández M,
|
||
López López F,
|
||
Díaz Pedroche C,
|
||
Gómez-Martín C</span><br />
|
||
<span class="medgenPMjournal">Gastroenterol Hepatol</span>
|
||
2018 May;41(5):310-311.
|
||
Epub 2017 Jun 24
|
||
doi: 10.1016/j.gastrohep.2017.05.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28655409" target="_blank">28655409</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18774375">Risk stratification of patients diagnosed with gastrointestinal stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Joensuu H</span><br />
|
||
<span class="medgenPMjournal">Hum Pathol</span>
|
||
2008 Oct;39(10):1411-9.
|
||
doi: 10.1016/j.humpath.2008.06.025.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18774375" target="_blank">18774375</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastrointestinal%20stromal%20tumor%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1251)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33879215">The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tariq MU,
|
||
Din NU,
|
||
Abdul-Ghafar J,
|
||
Park YK</span><br />
|
||
<span class="medgenPMjournal">Diagn Pathol</span>
|
||
2021 Apr 20;16(1):32.
|
||
doi: 10.1186/s13000-021-01095-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33879215" target="_blank">33879215</a><a href="/pmc/articles/PMC8059036" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30253395">Cytological Findings of Gastrointestinal Stromal Tumor-Derived Bone Metastasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kanda H,
|
||
Furuta N,
|
||
Takazawa Y,
|
||
Furuta R,
|
||
Ae K,
|
||
Sugiyama Y,
|
||
Ishikawa Y</span><br />
|
||
<span class="medgenPMjournal">Acta Cytol</span>
|
||
2018;62(5-6):430-435.
|
||
Epub 2018 Sep 25
|
||
doi: 10.1159/000492709.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30253395" target="_blank">30253395</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29589059">Cinematic rendering of small bowel pathology: preliminary observations from this novel 3D CT visualization method.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rowe SP,
|
||
Chu LC,
|
||
Fishman EK</span><br />
|
||
<span class="medgenPMjournal">Abdom Radiol (NY)</span>
|
||
2018 Nov;43(11):2928-2937.
|
||
doi: 10.1007/s00261-018-1578-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29589059" target="_blank">29589059</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27166665">Targeted treatments of sarcomas and connective tumors beside gastrointestinal stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martin-Broto J,
|
||
Hindi N</span><br />
|
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<span class="medgenPMjournal">Curr Opin Oncol</span>
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||
2016 Jul;28(4):338-44.
|
||
doi: 10.1097/CCO.0000000000000302.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27166665" target="_blank">27166665</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17927489">Sunitinib.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rini BI</span><br />
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<span class="medgenPMjournal">Expert Opin Pharmacother</span>
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||
2007 Oct;8(14):2359-69.
|
||
doi: 10.1517/14656566.8.14.2359.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17927489" target="_blank">17927489</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastrointestinal%20stromal%20tumor%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (889)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/30853211">Surgery for duodenal gastrointestinal stromal tumor: A systematic review and meta-analysis of pancreaticoduodenectomy versus local resection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou Y,
|
||
Wang X,
|
||
Si X,
|
||
Wang S,
|
||
Cai Z</span><br />
|
||
<span class="medgenPMjournal">Asian J Surg</span>
|
||
2020 Jan;43(1):1-8.
|
||
Epub 2019 Mar 8
|
||
doi: 10.1016/j.asjsur.2019.02.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30853211" target="_blank">30853211</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31435178">Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Waidhauser J,
|
||
Bornemann A,
|
||
Trepel M,
|
||
Märkl B</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2019 Aug 14;25(30):4261-4277.
|
||
doi: 10.3748/wjg.v25.i30.4261.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31435178" target="_blank">31435178</a><a href="/pmc/articles/PMC6700699" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31399553">Epithelioid Malignant Peripheral Nerve Sheath Tumor (Epithelioid-MPNST) Presenting as Bleeding Rectal Polyp: A Case Report with Systematic Literature Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patra S,
|
||
Ayyanar P,
|
||
Padhi S,
|
||
Purkait S,
|
||
Muduly DK,
|
||
Samal SC</span><br />
|
||
<span class="medgenPMjournal">Am J Case Rep</span>
|
||
2019 Aug 10;20:1175-1181.
|
||
doi: 10.12659/AJCR.916251.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31399553" target="_blank">31399553</a><a href="/pmc/articles/PMC6698063" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29685489">Imaging pediatric gastrointestinal stromal tumor (GIST).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Herzberg M,
|
||
Beer M,
|
||
Anupindi S,
|
||
Vollert K,
|
||
Kröncke T</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Surg</span>
|
||
2018 Sep;53(9):1862-1870.
|
||
Epub 2018 Mar 29
|
||
doi: 10.1016/j.jpedsurg.2018.03.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29685489" target="_blank">29685489</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29658644">Current status and future perspectives of endoscopic full-thickness resection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mori H,
|
||
Kobara H,
|
||
Nishiyama N,
|
||
Masaki T</span><br />
|
||
<span class="medgenPMjournal">Dig Endosc</span>
|
||
2018 Apr;30 Suppl 1:25-31.
|
||
doi: 10.1111/den.13042.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29658644" target="_blank">29658644</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastrointestinal%20stromal%20tumor%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (40)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
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|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
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|
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|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (74)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A1%5F3" target="_blank">Immunohistochemistry (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (16)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (92)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238198%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (20)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0238198%5bDISCUI%5d" target="_blank">See all (129)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=606764" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=44890" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Gastrointestinal%20stromal%20tumor" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22gastrointestinal%20stromal%20tumor%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Gastrointestinal%20stromal%20tumor%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024</div></li><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/gist.pdf">NCCN, 2023</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastrointestinal Stromal Tumors, 2023</div></li></ul></div>
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||
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|
||
<div class="portlet mgSection" id="ID_115">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=164920%20185470%20602413" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=3815[geneid]" target="_blank">View KIT variations in ClinVar</a></li><li><a href="/clinvar/?term=6390[geneid]" target="_blank">View SDHB variations in ClinVar</a></li><li><a href="/clinvar/?term=6391[geneid]" target="_blank">View SDHC variations in ClinVar</a></li><li><a href="/nuccore/170014706,241666451,256418952" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=606764" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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