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1036 lines
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99 KiB
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<!--
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||
UID=43224
|
||
ConceptID=C0085652
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Pyoderma gangrenosum</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>43224</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0085652</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Pyoderma Gangrenosum</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Pyoderma gangrenosum (74578003)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_989040"><div><strong>Unknown inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>989040</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307042</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">Hereditary clinical entity whose mode of inheritance is unknown.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/989040">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_989040" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Unknown inheritance</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0025452">HP:0025452</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0018824" target="_blank">MONDO:0018824</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=48104">ORPHA48104</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A deep skin ulcer with a well defined border, which is usually violet or blue. The ulcer edge is often undermined (worn and damaged) and the surrounding skin is erythematous and indurated. The ulcer often starts as a small papule or collection of papules, which break down to form small ulcers with a so called cat's paw appearance. These coalesce and the central area then undergoes necrosis to form a single ulcer. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0085652[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=43224">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Pyoderma gangrenosum</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1842398" ref="tree=MeSH" title="MedGen record for Autoinflammatory syndrome with skin involvement">Autoinflammatory syndrome with skin involvement</a></span><ul><li><span class="matched_ds">Pyoderma gangrenosum</span><ul><li><span class="TLline"><a href="/medgen/590609" ref="tree=MeSH" title="MedGen record for Bullous pyoderma gangrenosum">Bullous pyoderma gangrenosum</a></span></li><li><span class="TLline"><a href="/medgen/1814456" ref="tree=MeSH" title="MedGen record for Classic pyoderma gangrenosum">Classic pyoderma gangrenosum</a></span></li><li><span class="TLline"><a href="/medgen/1814476" ref="tree=MeSH" title="MedGen record for Pustular pyoderma gangrenosum">Pustular pyoderma gangrenosum</a></span></li><li><span class="TLline"><a href="/medgen/1842944" ref="tree=MeSH" title="MedGen record for Vegetative pyoderma gangrenosum">Vegetative pyoderma gangrenosum</a></span></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=10613&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Pyoderma gangrenosum</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_43097"><div><strong>Acute febrile neutrophilic dermatosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>43097</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085077</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Acute febrile neutrophilic dermatosis (AFND) is an autosomal dominant autoinflammatory disorder characterized by onset of recurrent fever and dermatologic abnormalities in childhood. Laboratory studies show elevated acute-phase reactants and activation of the inflammatory response, particularly IL1B (147720). Additional more variable features may include myalgia and arthralgia (summary by Masters et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/43097">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78795"><div><strong>Lazy leukocyte syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78795</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0272174</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Periodic fever, immunodeficiency, and thrombocytopenia syndrome (PFITS) is an autosomal recessive immunologic disorder with variable manifestations. Common features include early-onset recurrent respiratory infections, stomatitis, and cutaneous infections. Organisms usually include bacteria such as pneumococcus, Staphylococcus, and H. influenzae, but severe viral infections, including varicella, may also occur. Laboratory investigations may show neutropenia, neutrophilia, leukocytosis, or lymphopenia, although levels of immune cells may also be normal. Detailed studies often show impaired neutrophil chemotaxis associated with increased or abnormal F-actin levels, and impaired, normal, or even increased oxidative burst, depending on the stimulus. B- and T-cell abnormalities have also been observed. Some patients develop autoimmune manifestations, including chronic thrombocytopenia, anemia, and periodic fevers, associated with activation of the inflammasome. Early death may occur; however, hematopoietic stem cell transplantation may be curative (summary by Kuhns et al., 2016, Standing et al., 2017, and Pfajfer et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78795">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_346801"><div><strong>Pyogenic arthritis-pyoderma gangrenosum-acne syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>346801</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858361</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) is a rare autosomal dominant autoinflammatory disease that typically presents with recurrent sterile, erosive arthritis in childhood, occurring spontaneously or after minor trauma, occasionally resulting in significant joint destruction. By puberty, joint symptoms tend to subside and cutaneous symptoms predominate, including pathergy, frequently with abscesses at the sites of injections, severe cystic acne, and recurrent nonhealing sterile ulcers, often diagnosed as pyoderma gangrenosum (summary by Demidowich et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/346801">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_906018"><div><strong>Immunodeficiency, common variable, 12</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>906018</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225277</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Common variable immunodeficiency-12 with autoimmunity (CVID12) is an autosomal dominant complex immunologic disorder with multisystem involvement. CVID12 is mainly a primary immunodeficiency characterized by recurrent infections and associated with hypogammaglobulinemia. Notably, about half of patients develop autoimmune features, including cytopenia, as well as generalized inflammation and lymphoproliferation manifest as lymphadenopathy or hepatosplenomegaly. A smaller percentage of affected individuals (less than 20%) develop cancer, most commonly solid tumors, including lymphoma. Age at onset and disease severity are highly variable, even within the same family. There is also incomplete penetrance, such that mutation carriers may be asymptomatic, even if they have hypogammaglobulinemia. The gene involved, NFKB1, encodes a transcription factor that regulates the expression of target genes involved in the immune system, thus defining the phenotype as a disorder of immune dysregulation (summary by Fliegauf et al., 2015; Lorenzini et al., 2020). For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (607594).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/906018">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1823965"><div><strong>Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823965</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774192</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Immunodeficiency-107 with susceptibility to invasive Staphylococcus aureus infection (IMD107) is an autosomal dominant immunologic disorder characterized most often by the development of invasive and severe life-threatening infections with S. aureus affecting the skin and/or lungs. There is incomplete penetrance (about 30%) and variable expressivity. In some patients with heterozygous OTULIN mutations, an infectious agent is not identified, suggesting that low-grade infectious or even noninfectious triggers may play a role in development of the disease. The levels and function of immune cells appear normal; the molecular defect resides in fibroblasts and possibly other nonhematopoietic barrier cells that show increased susceptibility to the detrimental effects of the S. aureus alpha-toxin (Spaan et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1823965">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_43097" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acute febrile neutrophilic dermatosis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823965" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_906018" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency, common variable, 12</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78795" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lazy leukocyte syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_346801" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pyogenic arthritis-pyoderma gangrenosum-acne syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38423680">Treatment of Pyoderma Gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tan MG,
|
||
Tolkachjov SN</span><br />
|
||
<span class="medgenPMjournal">Dermatol Clin</span>
|
||
2024 Apr;42(2):183-192.
|
||
Epub 2023 Dec 29
|
||
doi: 10.1016/j.det.2023.12.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38423680" target="_blank">38423680</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37610614">Pyoderma Gangrenosum: Treatment Options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dissemond J,
|
||
Marzano AV,
|
||
Hampton PJ,
|
||
Ortega-Loayza AG</span><br />
|
||
<span class="medgenPMjournal">Drugs</span>
|
||
2023 Sep;83(14):1255-1267.
|
||
Epub 2023 Aug 23
|
||
doi: 10.1007/s40265-023-01931-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37610614" target="_blank">37610614</a><a href="/pmc/articles/PMC10511384" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34358489">Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rogler G,
|
||
Singh A,
|
||
Kavanaugh A,
|
||
Rubin DT</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2021 Oct;161(4):1118-1132.
|
||
Epub 2021 Aug 3
|
||
doi: 10.1053/j.gastro.2021.07.042.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34358489" target="_blank">34358489</a><a href="/pmc/articles/PMC8564770" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22pyoderma%20gangrenosum%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (194)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35870984">Neutrophilic dermatoses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Delaleu J,
|
||
Lepelletier C,
|
||
Calugareanu A,
|
||
De Masson A,
|
||
Charvet E,
|
||
Petit A,
|
||
Giurgea I,
|
||
Amselem S,
|
||
Karabina S,
|
||
Jachiet M,
|
||
Mahevas T,
|
||
Ram-Wolff C,
|
||
Vignon-Pennamen MD,
|
||
Bagot M,
|
||
Battistella M,
|
||
Bouaziz JD</span><br />
|
||
<span class="medgenPMjournal">Rev Med Interne</span>
|
||
2022 Dec;43(12):727-738.
|
||
Epub 2022 Jul 20
|
||
doi: 10.1016/j.revmed.2022.06.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35870984" target="_blank">35870984</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35606650">Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treatments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maronese CA,
|
||
Pimentel MA,
|
||
Li MM,
|
||
Genovese G,
|
||
Ortega-Loayza AG,
|
||
Marzano AV</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Dermatol</span>
|
||
2022 Sep;23(5):615-634.
|
||
Epub 2022 May 24
|
||
doi: 10.1007/s40257-022-00699-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35606650" target="_blank">35606650</a><a href="/pmc/articles/PMC9464730" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34358489">Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rogler G,
|
||
Singh A,
|
||
Kavanaugh A,
|
||
Rubin DT</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2021 Oct;161(4):1118-1132.
|
||
Epub 2021 Aug 3
|
||
doi: 10.1053/j.gastro.2021.07.042.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34358489" target="_blank">34358489</a><a href="/pmc/articles/PMC8564770" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30736994">Cutaneous paraneoplastic syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wick MR,
|
||
Patterson JW</span><br />
|
||
<span class="medgenPMjournal">Semin Diagn Pathol</span>
|
||
2019 Jul;36(4):211-228.
|
||
Epub 2019 Jan 31
|
||
doi: 10.1053/j.semdp.2019.01.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30736994" target="_blank">30736994</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30445584">The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hedin CRH,
|
||
Vavricka SR,
|
||
Stagg AJ,
|
||
Schoepfer A,
|
||
Raine T,
|
||
Puig L,
|
||
Pleyer U,
|
||
Navarini A,
|
||
van der Meulen-de Jong AE,
|
||
Maul J,
|
||
Katsanos K,
|
||
Kagramanova A,
|
||
Greuter T,
|
||
González-Lama Y,
|
||
van Gaalen F,
|
||
Ellul P,
|
||
Burisch J,
|
||
Bettenworth D,
|
||
Becker MD,
|
||
Bamias G,
|
||
Rieder F</span><br />
|
||
<span class="medgenPMjournal">J Crohns Colitis</span>
|
||
2019 Apr 26;13(5):541-554.
|
||
doi: 10.1093/ecco-jcc/jjy191.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30445584" target="_blank">30445584</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pyoderma%20gangrenosum%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (567)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37673429">Pyoderma gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yeung KCY,
|
||
O'Connor EM,
|
||
Hull PR</span><br />
|
||
<span class="medgenPMjournal">BMJ</span>
|
||
2023 Sep 6;382:e075863.
|
||
doi: 10.1136/bmj-2023-075863.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37673429" target="_blank">37673429</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36351270">Pyoderma Gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou HY,
|
||
Liu ZH</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2022 Nov 10;387(19):e48.
|
||
doi: 10.1056/NEJMicm2204111.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36351270" target="_blank">36351270</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34910081">Pyoderma Gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hou YL,
|
||
Lee CH</span><br />
|
||
<span class="medgenPMjournal">JAMA Dermatol</span>
|
||
2022 Feb 1;158(2):202.
|
||
doi: 10.1001/jamadermatol.2021.5001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34910081" target="_blank">34910081</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34538436">Pyoderma Gangrenosum: A Literature Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barbe M,
|
||
Batra A,
|
||
Golding S,
|
||
Hammond O,
|
||
Higgins JC,
|
||
O'Connor A,
|
||
Vlahovic TC</span><br />
|
||
<span class="medgenPMjournal">Clin Podiatr Med Surg</span>
|
||
2021 Oct;38(4):577-588.
|
||
doi: 10.1016/j.cpm.2021.06.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34538436" target="_blank">34538436</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26551510">Pyoderma gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mehrtens SH,
|
||
Crawley JM</span><br />
|
||
<span class="medgenPMjournal">Br J Hosp Med (Lond)</span>
|
||
2015 Nov;76(11):C173-6.
|
||
doi: 10.12968/hmed.2015.76.11.C173.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26551510" target="_blank">26551510</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pyoderma%20gangrenosum%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1400)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38423680">Treatment of Pyoderma Gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tan MG,
|
||
Tolkachjov SN</span><br />
|
||
<span class="medgenPMjournal">Dermatol Clin</span>
|
||
2024 Apr;42(2):183-192.
|
||
Epub 2023 Dec 29
|
||
doi: 10.1016/j.det.2023.12.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38423680" target="_blank">38423680</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37610614">Pyoderma Gangrenosum: Treatment Options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dissemond J,
|
||
Marzano AV,
|
||
Hampton PJ,
|
||
Ortega-Loayza AG</span><br />
|
||
<span class="medgenPMjournal">Drugs</span>
|
||
2023 Sep;83(14):1255-1267.
|
||
Epub 2023 Aug 23
|
||
doi: 10.1007/s40265-023-01931-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37610614" target="_blank">37610614</a><a href="/pmc/articles/PMC10511384" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31548193">Ulcerative pyoderma gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sander M,
|
||
Sander M</span><br />
|
||
<span class="medgenPMjournal">CMAJ</span>
|
||
2019 Sep 23;191(38):E1058.
|
||
doi: 10.1503/cmaj.190721.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31548193" target="_blank">31548193</a><a href="/pmc/articles/PMC6763329" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28629662">Pyoderma gangrenosum: Classic and emerging therapies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Soto Vilches F,
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<span class="medgenPMjournal">Med Clin (Barc)</span>
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2017 Sep 20;149(6):256-260.
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<span class="bold">PMID: </span><a href="/pubmed/28629662" target="_blank">28629662</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/20213372">Pyoderma gangrenosum.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hoff NP,
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Bölke E,
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Matuschek C,
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Peiper M,
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Neumann NJ,
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2010 Feb;122(3-4):75.
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pyoderma%20gangrenosum%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1365)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/34538436">Pyoderma Gangrenosum: A Literature Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Barbe M,
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Batra A,
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Golding S,
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Hammond O,
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Higgins JC,
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O'Connor A,
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<span class="bold">PMID: </span><a href="/pubmed/34538436" target="_blank">34538436</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34358489">Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Rogler G,
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Singh A,
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Kavanaugh A,
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Rubin DT</span><br />
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2021 Oct;161(4):1118-1132.
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Epub 2021 Aug 3
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doi: 10.1053/j.gastro.2021.07.042.
|
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<span class="bold">PMID: </span><a href="/pubmed/34358489" target="_blank">34358489</a><a href="/pmc/articles/PMC8564770" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31927079">Perioperative management of pyoderma gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haag CK,
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Bacik L,
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Latour E,
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Morse DC,
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Fett NM,
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Ortega-Loayza AG</span><br />
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<span class="medgenPMjournal">J Am Acad Dermatol</span>
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2020 Aug;83(2):369-374.
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Epub 2020 Jan 9
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doi: 10.1016/j.jaad.2020.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31927079" target="_blank">31927079</a></div>
|
||
|
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<div class="nl"><a target="_blank" href="/pubmed/26154136">Extraintestinal Manifestations of Inflammatory Bowel Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vavricka SR,
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Schoepfer A,
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Scharl M,
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Lakatos PL,
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Navarini A,
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2015 Aug;21(8):1982-92.
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doi: 10.1097/MIB.0000000000000392.
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<span class="bold">PMID: </span><a href="/pubmed/26154136" target="_blank">26154136</a><a href="/pmc/articles/PMC4511685" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
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||
<div class="nl"><a target="_blank" href="/pubmed/11308137">Behçet disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee LA</span><br />
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<span class="medgenPMjournal">Semin Cutan Med Surg</span>
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2001 Mar;20(1):53-7.
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doi: 10.1053/sder.2001.23097.
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<span class="bold">PMID: </span><a href="/pubmed/11308137" target="_blank">11308137</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pyoderma%20gangrenosum%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (438)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/37610614">Pyoderma Gangrenosum: Treatment Options.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Dissemond J,
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Marzano AV,
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Hampton PJ,
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Ortega-Loayza AG</span><br />
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<span class="medgenPMjournal">Drugs</span>
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2023 Sep;83(14):1255-1267.
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Epub 2023 Aug 23
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doi: 10.1007/s40265-023-01931-3.
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<span class="bold">PMID: </span><a href="/pubmed/37610614" target="_blank">37610614</a><a href="/pmc/articles/PMC10511384" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34538436">Pyoderma Gangrenosum: A Literature Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barbe M,
|
||
Batra A,
|
||
Golding S,
|
||
Hammond O,
|
||
Higgins JC,
|
||
O'Connor A,
|
||
Vlahovic TC</span><br />
|
||
<span class="medgenPMjournal">Clin Podiatr Med Surg</span>
|
||
2021 Oct;38(4):577-588.
|
||
doi: 10.1016/j.cpm.2021.06.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34538436" target="_blank">34538436</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34358489">Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rogler G,
|
||
Singh A,
|
||
Kavanaugh A,
|
||
Rubin DT</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2021 Oct;161(4):1118-1132.
|
||
Epub 2021 Aug 3
|
||
doi: 10.1053/j.gastro.2021.07.042.
|
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<span class="bold">PMID: </span><a href="/pubmed/34358489" target="_blank">34358489</a><a href="/pmc/articles/PMC8564770" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31927079">Perioperative management of pyoderma gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haag CK,
|
||
Bacik L,
|
||
Latour E,
|
||
Morse DC,
|
||
Fett NM,
|
||
Ortega-Loayza AG</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2020 Aug;83(2):369-374.
|
||
Epub 2020 Jan 9
|
||
doi: 10.1016/j.jaad.2020.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31927079" target="_blank">31927079</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31676787">Common and critical inflammatory dermatoses every pathologist should know.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Billings SD</span><br />
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<span class="medgenPMjournal">Mod Pathol</span>
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2020 Jan;33(Suppl 1):107-117.
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Epub 2019 Nov 1
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||
<span class="bold">PMID: </span><a href="/pubmed/31676787" target="_blank">31676787</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pyoderma%20gangrenosum%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (318)</a></div></div>
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|
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|
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<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38906261">Investigating historic cases of pyoderma gangrenosum in myelodysplastic syndrome and chronic myelomonocytic leukemia for possible VEXAS syndrome: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Croitoru DO,
|
||
Huang RS,
|
||
McMullen EP,
|
||
Maazi M,
|
||
Piguet V</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2024 Oct;91(4):712-714.
|
||
Epub 2024 Jun 19
|
||
doi: 10.1016/j.jaad.2024.05.086.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38906261" target="_blank">38906261</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37042969">Prevalence of Extraintestinal Manifestations in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kilic Y,
|
||
Kamal S,
|
||
Jaffar F,
|
||
Sriranganathan D,
|
||
Quraishi MN,
|
||
Segal JP</span><br />
|
||
<span class="medgenPMjournal">Inflamm Bowel Dis</span>
|
||
2024 Feb 1;30(2):230-239.
|
||
doi: 10.1093/ibd/izad061.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37042969" target="_blank">37042969</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35323998">Juvenile gangrenous vasculitis of the scrotum: systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bazzi N,
|
||
Salloum A,
|
||
Chebl JA,
|
||
Hreibe W,
|
||
Bazzi M,
|
||
Fiani E,
|
||
Benedetto A,
|
||
Moussa M</span><br />
|
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<span class="medgenPMjournal">Int J Dermatol</span>
|
||
2022 Nov;61(11):1364-1371.
|
||
Epub 2022 Mar 24
|
||
doi: 10.1111/ijd.16066.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35323998" target="_blank">35323998</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34942295">Clinical manifestations and treatment outcomes of pyoderma gangrenosum following rituximab exposure: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Croitoru D,
|
||
Nathanielsz N,
|
||
Seigel K,
|
||
Elsawi R,
|
||
Sibbald C,
|
||
Alavi A,
|
||
Zipursky J,
|
||
Piguet V</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2022 Sep;87(3):655-656.
|
||
Epub 2021 Dec 20
|
||
doi: 10.1016/j.jaad.2021.12.028.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34942295" target="_blank">34942295</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31927079">Perioperative management of pyoderma gangrenosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haag CK,
|
||
Bacik L,
|
||
Latour E,
|
||
Morse DC,
|
||
Fett NM,
|
||
Ortega-Loayza AG</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2020 Aug;83(2):369-374.
|
||
Epub 2020 Jan 9
|
||
doi: 10.1016/j.jaad.2020.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31927079" target="_blank">31927079</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pyoderma%20gangrenosum%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (57)</a></div></div>
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