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<meta name="keywords" content="C0085580, disease or syndrome, eht, essential hypertension, hypertension, essential, hypertension, primary, hypertensions, primary, idiopathic hypertension, non rare in europe: essential hypertension, primary hypertension, primary hypertensions, systemic primary arterial hypertension, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution (Pickering, 1978). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait (Platt, 1963). McDonough et al. (1964) defended the monogenic idea. See McKusick (1960) and Kurtz and Spence (1993) for reviews. Swales (1985) reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=88442
|
||
ConceptID=C0085580
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Essential hypertension</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>88442</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0085580</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Essential Hypertension; Hypertension, Essential; Hypertension, Primary; Hypertensions, Primary; Primary Hypertension; Primary Hypertensions</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Essential hypertension (59621000); Idiopathic hypertension (59621000); Systemic primary arterial hypertension (59621000); Primary hypertension (59621000)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related genes:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/8490">RGS5</a>, <a target="_blank" href="/gene/5740">PTGIS</a>, <a target="_blank" href="/gene/4846">NOS3</a>, <a target="_blank" href="/gene/2784">GNB3</a>, <a target="_blank" href="/gene/1889">ECE1</a>, <a target="_blank" href="/gene/1577">CYP3A5</a>, <a target="_blank" href="/gene/481">ATP1B1</a>, <a target="_blank" href="/gene/185">AGTR1</a>, <a target="_blank" href="/gene/118">ADD1</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0001134" target="_blank">MONDO:0001134</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/145500" target="_blank">145500</a>; <a href="https://omim.org/entry/601699" target="_blank">601699</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=243761">ORPHA243761</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution (Pickering, 1978). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait (Platt, 1963). McDonough et al. (1964) defended the monogenic idea. See McKusick (1960) and Kurtz and Spence (1993) for reviews. Swales (1985) reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations. [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Hypertension is abnormally high blood pressure in the arteries, which are the blood vessels that carry blood from the heart to the rest of the body. As the heart beats, it forces blood through the arteries to deliver nutrients and oxygen to the rest of the body. The strength of the blood pushing against the artery walls is blood pressure, which is measured in units called millimeters of mercury (mmHg). The top number in a blood pressure reading is the pressure when the heart pumps (systolic blood pressure), and the bottom number is the pressure between heart beats (diastolic blood pressure). In adults, a normal blood pressure measurement is about 120/80 mmHg. Blood pressure is considered high when the measurement is 130/80 mmHg or greater.<br /><br />Hypertension usually has no symptoms, and many affected individuals do not know they have the condition. However, hypertension is a major risk factor for heart disease, stroke, kidney failure, and eye problems. When blood pressure is elevated, the heart and arteries have to work harder than normal to pump blood through the body. The extra work thickens the muscles of the heart and arteries and hardens or damages artery walls. As a result, the flow of blood and oxygen to the heart and other organs is reduced. Damage to the heart caused by the extra work and a lack of oxygen causes heart disease. In addition, damage to the arteries increases the risk of blood clots that block the flow of blood to the heart, causing a heart attack, or to the brain, causing a type of stroke known as an ischemic stroke. Another type of stroke, called a hemorrhagic stroke, can occur when a weakened blood vessel in the brain bursts. Damage to blood vessels in the kidneys impairs their ability to filter waste and remove fluid, leading to kidney failure. Problems with blood flow in the arteries of the eyes can lead to vision loss.<br /><br />In rare cases, dangerously high blood pressure can cause severe headaches, confusion, shortness of breath, chest pain, or nosebleeds.<br /><br />In about 95 percent of cases, the cause of hypertension is unknown. These cases are classified as essential hypertension. When hypertension results from an underlying condition, such as blood vessel defects that reduce blood flow; kidney disorders, which alter the amount of fluids and salts in the body; or problems with hormone-producing glands called the adrenal glands or the thyroid gland, it is classified as secondary hypertension. Hypertension is a key feature of some rare genetic disorders, including familial hyperaldosteronism, pseudohypoaldosteronism type 2, Liddle syndrome, and tumors known as paragangliomas. <a target="_blank" href="https://medlineplus.gov/genetics/condition/hypertension">https://medlineplus.gov/genetics/condition/hypertension</a></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_333547"><div><strong>Elevated systolic blood pressure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333547</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1840374</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormal increase in systolic blood pressure.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/333547">Feature record</a> | <a href="/medgen?term=%22Elevated%20systolic%20blood%20pressure%22%5BClinical%20Features%5D%20OR%20333547%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_374454"><div><strong>Elevated diastolic blood pressure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>374454</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1840375</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormal increase in diastolic blood pressure.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/374454">Feature record</a> | <a href="/medgen?term=%22Elevated%20diastolic%20blood%20pressure%22%5BClinical%20Features%5D%20OR%20374454%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_326719"><div><strong>Elevated mean arterial pressure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>326719</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1840376</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An abnormal increase in the average blood pressure in an individual during a single cardiac cycle.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/326719">Feature record</a> | <a href="/medgen?term=%22Elevated%20mean%20arterial%20pressure%22%5BClinical%20Features%5D%20OR%20326719%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_374454" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Elevated diastolic blood pressure</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_326719" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Elevated mean arterial pressure</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_333547" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Elevated systolic blood pressure</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0085580[DISCUI]&test_type=Clinical" ref="ncbi_uid=88442">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=88442" target="_blank" href="/omim/145500">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=88442" ref="ncbi_uid=88442">V</a></span></span><span class="TLline">Essential hypertension</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/56371" ref="tree=GTR&ncbi_uid=56371&link_uid=56371" title="View MedGen record for 'Benign essential hypertension'">Benign essential hypertension</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN305331[DISCUI]&test_type=Clinical" ref="ncbi_uid=987958">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=987958" ref="ncbi_uid=987958">V</a></span></span><span class="TLline"><a href="/medgen/987958" ref="tree=GTR&ncbi_uid=987958&link_uid=987958" title="View MedGen record for 'Essential hypertension, genetic'">Essential hypertension, genetic</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/9866" ref="tree=GTR&ncbi_uid=9866&link_uid=9866" title="View MedGen record for 'Malignant essential hypertension'">Malignant essential hypertension</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/272632" ref="tree=MeSH" title="MedGen record for Finding by Site or System">Finding by Site or System</a></span><ul><li><span class="TLline"><a href="/medgen/96114" ref="tree=MeSH" title="MedGen record for Cardiovascular finding">Cardiovascular finding</a></span><ul><li><span class="TLline"><a href="/medgen/224789" ref="tree=MeSH" title="MedGen record for Blood pressure finding">Blood pressure finding</a></span><ul><li><span class="TLline"><a href="/medgen/6969" ref="tree=MeSH" title="MedGen record for Hypertensive disorder">Hypertensive disorder</a></span><ul><li><span class="matched_ds">Essential hypertension</span><ul><li><span class="TLline"><a href="/medgen/56371" ref="tree=MeSH" title="MedGen record for Benign essential hypertension">Benign essential hypertension</a></span></li><li><span class="TLline"><a href="/medgen/987958" ref="tree=MeSH" title="MedGen record for Essential hypertension, genetic">Essential hypertension, genetic</a></span></li><li><span class="TLline"><a href="/medgen/9866" ref="tree=MeSH" title="MedGen record for Malignant essential hypertension">Malignant essential hypertension</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38604225">Outpatient management of essential hypertension: a review based on the latest clinical guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moiz A,
|
||
Zolotarova T,
|
||
Eisenberg MJ</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
2024 Dec;56(1):2338242.
|
||
Epub 2024 Apr 11
|
||
doi: 10.1080/07853890.2024.2338242.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38604225" target="_blank">38604225</a><a href="/pmc/articles/PMC11011233" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36740773">Aldosterone Synthase Inhibitors and the Treatment of Essential Hypertension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gomez-Sanchez CE,
|
||
Gomez-Sanchez EP</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2023 Jul 14;108(8):e638-e639.
|
||
doi: 10.1210/clinem/dgad071.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36740773" target="_blank">36740773</a><a href="/pmc/articles/PMC10348457" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21963308">Etiology and management of postpartum hypertension-preeclampsia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sibai BM</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2012 Jun;206(6):470-5.
|
||
Epub 2011 Sep 16
|
||
doi: 10.1016/j.ajog.2011.09.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21963308" target="_blank">21963308</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22essential%20hypertension%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1016)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng136" target="_blank">UK NICE Guideline NG136, Hypertension in adults: diagnosis and management, 2023</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38236144">Homocysteine, hyperhomocysteinemia, and H-type hypertension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wu DF,
|
||
Yin RX,
|
||
Deng JL</span><br />
|
||
<span class="medgenPMjournal">Eur J Prev Cardiol</span>
|
||
2024 Jul 23;31(9):1092-1103.
|
||
doi: 10.1093/eurjpc/zwae022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38236144" target="_blank">38236144</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37432701">Efficacy of single-pill combination in uncontrolled essential hypertension: A systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xie M,
|
||
Tang T,
|
||
Liang H</span><br />
|
||
<span class="medgenPMjournal">Clin Cardiol</span>
|
||
2023 Aug;46(8):886-898.
|
||
Epub 2023 Jul 11
|
||
doi: 10.1002/clc.24082.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37432701" target="_blank">37432701</a><a href="/pmc/articles/PMC10436803" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35708557">The Effect of Aromatherapy on Blood Pressure and Stress Responses by Inhalation and Foot Massage in Patients With Essential Hypertension: Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Can Çiçek S,
|
||
Demir Ş,
|
||
Yılmaz D,
|
||
Açıkgöz A,
|
||
Yıldız S,
|
||
Yis ÖM</span><br />
|
||
<span class="medgenPMjournal">Holist Nurs Pract</span>
|
||
2022 Jul-Aug 01;36(4):209-222.
|
||
doi: 10.1097/HNP.0000000000000526.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35708557" target="_blank">35708557</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30920923">Precision Medicine.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Loscalzo J</span><br />
|
||
<span class="medgenPMjournal">Circ Res</span>
|
||
2019 Mar 29;124(7):987-989.
|
||
doi: 10.1161/CIRCRESAHA.119.314403.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30920923" target="_blank">30920923</a><a href="/pmc/articles/PMC6501802" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29129575">Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Monticone S,
|
||
D'Ascenzo F,
|
||
Moretti C,
|
||
Williams TA,
|
||
Veglio F,
|
||
Gaita F,
|
||
Mulatero P</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2018 Jan;6(1):41-50.
|
||
Epub 2017 Nov 9
|
||
doi: 10.1016/S2213-8587(17)30319-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29129575" target="_blank">29129575</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Essential%20hypertension%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9064)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38236144">Homocysteine, hyperhomocysteinemia, and H-type hypertension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wu DF,
|
||
Yin RX,
|
||
Deng JL</span><br />
|
||
<span class="medgenPMjournal">Eur J Prev Cardiol</span>
|
||
2024 Jul 23;31(9):1092-1103.
|
||
doi: 10.1093/eurjpc/zwae022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38236144" target="_blank">38236144</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37432701">Efficacy of single-pill combination in uncontrolled essential hypertension: A systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xie M,
|
||
Tang T,
|
||
Liang H</span><br />
|
||
<span class="medgenPMjournal">Clin Cardiol</span>
|
||
2023 Aug;46(8):886-898.
|
||
Epub 2023 Jul 11
|
||
doi: 10.1002/clc.24082.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37432701" target="_blank">37432701</a><a href="/pmc/articles/PMC10436803" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36561082">Pharmacotherapy for Essential Hypertension: A Brief Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heidari B,
|
||
Avenatti E,
|
||
Nasir K</span><br />
|
||
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
|
||
2022;18(5):5-16.
|
||
Epub 2022 Dec 6
|
||
doi: 10.14797/mdcvj.1175.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36561082" target="_blank">36561082</a><a href="/pmc/articles/PMC9733188" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30920923">Precision Medicine.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Loscalzo J</span><br />
|
||
<span class="medgenPMjournal">Circ Res</span>
|
||
2019 Mar 29;124(7):987-989.
|
||
doi: 10.1161/CIRCRESAHA.119.314403.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30920923" target="_blank">30920923</a><a href="/pmc/articles/PMC6501802" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17707755">Essential hypertension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Messerli FH,
|
||
Williams B,
|
||
Ritz E</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2007 Aug 18;370(9587):591-603.
|
||
doi: 10.1016/S0140-6736(07)61299-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17707755" target="_blank">17707755</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Essential%20hypertension%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4237)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28807582">Comparative Efficacy of Angiotensin II Antagonists in Essential Hypertension: Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsoi B,
|
||
Akioyamen LE,
|
||
Bonner A,
|
||
Frankfurter C,
|
||
Levine M,
|
||
Pullenayegum E,
|
||
Goeree R,
|
||
O'Reilly D</span><br />
|
||
<span class="medgenPMjournal">Heart Lung Circ</span>
|
||
2018 Jun;27(6):666-682.
|
||
Epub 2017 Jul 14
|
||
doi: 10.1016/j.hlc.2017.06.721.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28807582" target="_blank">28807582</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26419755">Vitamin D deficiency and essential hypertension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen S,
|
||
Sun Y,
|
||
Agrawal DK</span><br />
|
||
<span class="medgenPMjournal">J Am Soc Hypertens</span>
|
||
2015 Nov;9(11):885-901.
|
||
Epub 2015 Aug 21
|
||
doi: 10.1016/j.jash.2015.08.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26419755" target="_blank">26419755</a><a href="/pmc/articles/PMC4641765" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23333908">Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies.</a></div>
|
||
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Essential%20hypertension%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8100)</a></div><h3 class="subhead">Prognosis</h3>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Essential%20hypertension%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2689)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chen H,
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Shen FE,
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Tan XD,
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<div class="nl"><a target="_blank" href="/pubmed/29228086">New Methods to Study the Microcirculation.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rizzoni D,
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Agabiti Rosei C,
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De Ciuceis C,
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Semeraro F,
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Rizzoni M,
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<div class="nl"><a target="_blank" href="/pubmed/7587001">Microalbuminuria: prognostic and therapeutic implications in diabetic and hypertensive pregnancy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bar J,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Essential%20hypertension%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4861)</a></div></div>
|
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</div>
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|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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||
<div class="nl"><a target="_blank" href="/pubmed/37432701">Efficacy of single-pill combination in uncontrolled essential hypertension: A systematic review and network meta-analysis.</a></div>
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Tang T,
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<span class="bold">PMID: </span><a href="/pubmed/37432701" target="_blank">37432701</a><a href="/pmc/articles/PMC10436803" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36209937">Low-dose aspirin for the prevention of superimposed preeclampsia in women with chronic hypertension: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Richards EMF,
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Giorgione V,
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Stevens O,
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Thilaganathan B</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/36209937" target="_blank">36209937</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/36181637">HOMA-IR as a predictor of Health Outcomes in Patients with Metabolic Risk Factors: A Systematic Review and Meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">González-González JG,
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Violante-Cumpa JR,
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Zambrano-Lucio M,
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Burciaga-Jimenez E,
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Castillo-Morales PL,
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Garcia-Campa M,
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Solis RC,
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González-Colmenero AD,
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<span class="bold">PMID: </span><a href="/pubmed/36181637" target="_blank">36181637</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29129575">Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Monticone S,
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D'Ascenzo F,
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Moretti C,
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Williams TA,
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Veglio F,
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Gaita F,
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2018 Jan;6(1):41-50.
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Epub 2017 Nov 9
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<span class="bold">PMID: </span><a href="/pubmed/29129575" target="_blank">29129575</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24990417">Massage therapy for essential hypertension: a systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Xiong XJ,
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Li SJ,
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Zhang YQ</span><br />
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2015 Mar;29(3):143-51.
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<span class="bold">PMID: </span><a href="/pubmed/24990417" target="_blank">24990417</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Essential%20hypertension%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (145)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0085580%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (26)</a></li>
|
||
<li><a href="/gtr/tests?term=C0085580%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (35)</a></li>
|
||
<li><a href="/gtr/tests?term=C0085580%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (6)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0085580%5bDISCUI%5d" target="_blank">See all (40)</a></total></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22essential%20hypertension%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Essential%20hypertension%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng136">NICE, 2023</a><div>UK NICE Guideline NG136, Hypertension in adults: diagnosis and management, 2023</div></li></ul></div>
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