1227 lines
No EOL
147 KiB
HTML
1227 lines
No EOL
147 KiB
HTML
<?xml version="1.0" encoding="utf-8"?>
|
||
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
||
<html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en">
|
||
<head xmlns:xi="http://www.w3.org/2001/XInclude"><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
||
<!-- meta -->
|
||
<meta name="keywords" content="C0025202, cancer of skin pigment cells, malignant melanoma, malignant melanomas, melanoma, melanoma (disease), melanoma, malignant, melanomas, melanomas, malignant, melanosarcoma, mm - malignant melanoma, naevocarcinoma, neoplastic process, non rare in europe: melanoma, skin cancer (melanoma), autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Melanoma is a type of skin cancer that begins in pigment-producing cells called melanocytes. This cancer typically occurs in areas that are only occasionally sun-exposed; tumors are most commonly found on the back in men and on the legs in women. Melanoma usually occurs on the skin (cutaneous melanoma), but in about 5 percent of cases it develops in melanocytes in other tissues, including the eyes (uveal melanoma) or mucous membranes that line the body's cavities, such as the moist lining of the mouth (mucosal melanoma). Melanoma can develop at any age, but it most frequently occurs in people in their fifties to seventies and is becoming more common in teenagers and young adults.\n\nA large number of moles or other pigmented skin growths on the body, generally more than 25, is associated with an increased risk of developing melanoma. Melanoma is also a common feature of genetic syndromes affecting the skin such as xeroderma pigmentosum. Additionally, individuals who have previously had melanoma are nearly nine times more likely than the general population to develop melanoma again. It is estimated that about 90 percent of individuals with melanoma survive at least 5 years after being diagnosed.\n\nMelanoma may develop from an existing mole or other normal skin growth that becomes cancerous (malignant); however, many melanomas are new growths. Melanomas often have ragged edges and an irregular shape. They can range from a few millimeters to several centimeters across. They can also be a variety of colors: brown, black, red, pink, blue, or white.\n\nMost melanomas affect only the outermost layer of skin (the epidermis). If a melanoma becomes thicker and involves multiple layers of skin, it can spread to other parts of the body (metastasize)." /><meta name="robots" content="index,nofollow,noarchive" />
|
||
<meta name="ncbi_app" content="entrez" /><meta name="ncbi_db" content="medgen" /><meta name="ncbi_term" content="c0025202[conceptid]" /><meta name="ncbi_report" content="fullreport" /><meta name="ncbi_format" content="html" /><meta name="ncbi_pagesize" content="20" /><meta name="ncbi_sortorder" content="default" /><meta name="ncbi_pageno" content="1" /><meta name="ncbi_resultcount" content="1" /><meta name="ncbi_op" content="search" /><meta name="ncbi_pdid" content="fullreport" /><meta name="ncbi_sessionid" content="CE8B5AF87C7FFCB1_0191SID" /><meta name="ncbi_filter" content="clinical" /><meta name="ncbi_stat" content="false" /><meta name="ncbi_hitstat" content="false" />
|
||
|
||
|
||
<!-- title -->
|
||
<title>Melanoma (Concept Id: C0025202)
|
||
- MedGen - NCBI</title>
|
||
|
||
<!-- Common JS and CSS -->
|
||
|
||
<script type="text/javascript">
|
||
var ncbi_startTime = new Date();
|
||
</script>
|
||
<script type="text/javascript" src="https://static.pubmed.gov/core/jig/1.15.10/js/jig.min.js"></script>
|
||
|
||
<link xmlns="http://www.w3.org/1999/xhtml" type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218191/css/4207974/4206132.css" xml:base="http://127.0.0.1/sites/static/header_footer/" />
|
||
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8BE6E47CD255C10000000000D900AF.m_32" /><script type="text/javascript"><!--
|
||
var ScriptPath = '/portal/';
|
||
var objHierarchy = {"name":"EntrezSystem2","type":"Layout","realname":"EntrezSystem2",
|
||
"children":[{"name":"EntrezSystem2.PEntrez","type":"Cluster","realname":"EntrezSystem2.PEntrez",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.DbConnector","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.DbConnector","shortname":"DbConnector"},
|
||
{"name":"EntrezSystem2.PEntrez.ParamContainer","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.ParamContainer","shortname":"ParamContainer"},
|
||
{"name":"EntrezSystem2.PEntrez.MyNcbi","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.MyNcbi","shortname":"MyNcbi"},
|
||
{"name":"EntrezSystem2.PEntrez.UserPreferenceUrlParamContainer","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.UserPreferenceUrlParamContainer","shortname":"UserPreferenceUrlParamContainer"},
|
||
{"name":"EntrezSystem2.PEntrez.GridProperty","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.GridProperty","shortname":"GridProperty"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NoPortlet","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NoPortlet","shortname":"NoPortlet"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_PageController","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_PageController","shortname":"MedGen_PageController"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_SearchBar","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_SearchBar","shortname":"MedGen_SearchBar"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_BotRequest","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_BotRequest","shortname":"MedGen_BotRequest"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_LimitsTab","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_LimitsTab","shortname":"MedGen_LimitsTab"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Facets","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Facets","shortname":"Entrez_Facets"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Clipboard","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Clipboard","shortname":"Entrez_Clipboard"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_StaticParts","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_StaticParts","shortname":"MedGen_StaticParts"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Messages","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Messages","shortname":"Entrez_Messages"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NcbiJSCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NcbiJSCheck","shortname":"NcbiJSCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.Footer_ExtraData","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.Footer_ExtraData","shortname":"Footer_ExtraData"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIBreadcrumbs","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIBreadcrumbs","shortname":"NCBIBreadcrumbs"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIHelpDesk","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIHelpDesk","shortname":"NCBIHelpDesk"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIApplog_NoScript_Ping","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIApplog_NoScript_Ping","shortname":"NCBIApplog_NoScript_Ping"}]}]},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.blankToolPanel","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.blankToolPanel","shortname":"blankToolPanel"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController","shortname":"MedGen_ResultsController"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_FiltersPortlet","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_FiltersPortlet","shortname":"MedGen_FiltersPortlet"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_Pager","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Entrez_Pager","shortname":"Entrez_Pager"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar","shortname":"MedGen_DisplayBar"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HelpFormAttributes","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.HelpFormAttributes","shortname":"HelpFormAttributes"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_Collections","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Entrez_Collections","shortname":"Entrez_Collections"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.SpellCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.SpellCheck","shortname":"SpellCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.SearchEngineReferralCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.SearchEngineReferralCheck","shortname":"SearchEngineReferralCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.WrongDbSensor","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.WrongDbSensor","shortname":"WrongDbSensor"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.KnowledgePanel","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.KnowledgePanel","shortname":"KnowledgePanel"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.HistoryDisplay","shortname":"HistoryDisplay"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Discovery_SearchDetails","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Discovery_SearchDetails","shortname":"Discovery_SearchDetails"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.mg_GeneSensor","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.mg_GeneSensor","shortname":"mg_GeneSensor"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ClinFeatureSearch","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ClinFeatureSearch","shortname":"MedGen_ClinFeatureSearch"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_RVFull","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_RVFull","shortname":"MedGen_RVFull"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks","shortname":"MedGenDiscoveryDbLinks"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGen_SingleItemSupl","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGen_SingleItemSupl","shortname":"MedGen_SingleItemSupl"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews","shortname":"MedGenReviews"}]}]}]}]}]};
|
||
--></script>
|
||
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/css/3808861/3917732/3974050/3751656/3395415/4221762/14534/4062871/4186458/4075711/12930/4033350/4128070/3861632/4013176/4212357/4064428/4186491/9685/2279/3395586.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/css/3501913/1303451.css" media="print" /><script type="text/javascript">
|
||
|
||
var ObjectLinks=[{i:0, ename: "p$ExL", esid:"*", sname: "p$ExL", ssid:"*", dname:"p$el", dsid:"0",m:"CopyValue",p:[],f: function(src, dst) {fn_CopyValue(src, dst);}}]
|
||
|
||
|
||
var ActiveNames = {"p$ExL":1, "EntrezSystem2.PEntrez.DbConnector.Cmd":0, "EntrezSystem2.PEntrez.DbConnector.Db":0, "EntrezSystem2.PEntrez.DbConnector.IdsFromResult":0, "EntrezSystem2.PEntrez.DbConnector.LastDb":0, "EntrezSystem2.PEntrez.DbConnector.LastIdsFromResult":0, "EntrezSystem2.PEntrez.DbConnector.LastQueryKey":0, "EntrezSystem2.PEntrez.DbConnector.LastTabCmd":0, "EntrezSystem2.PEntrez.DbConnector.LinkName":0, "EntrezSystem2.PEntrez.DbConnector.LinkReadableName":0, "EntrezSystem2.PEntrez.DbConnector.LinkSrcDb":0, "EntrezSystem2.PEntrez.DbConnector.QueryKey":0, "EntrezSystem2.PEntrez.DbConnector.TabCmd":0, "EntrezSystem2.PEntrez.DbConnector.Term":0, "EntrezSystem2.PEntrez.MedGen.MedGen_PageController.PreviousPageName":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FileFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Format":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Presentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevSort":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SetDisplay":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.ResultCount":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.RunLastQuery":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter":0};
|
||
</script></head>
|
||
<body>
|
||
<div class="grid">
|
||
<div class="col twelve_col nomargin shadow">
|
||
<form enctype="application/x-www-form-urlencoded" name="EntrezForm" method="post" onsubmit="return false;" action="/medgen" id="EntrezForm">
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<!-- no javascript message -->
|
||
<noscript>
|
||
<p class="nojs">
|
||
<strong>Warning:</strong>
|
||
The NCBI web site requires JavaScript to function.
|
||
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
||
</p>
|
||
</noscript>
|
||
|
||
<div xmlns="http://www.w3.org/1999/xhtml" id="universal_header" xml:base="http://127.0.0.1/sites/static/header_footer/">
|
||
<section class="usa-banner">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner-header">
|
||
<div class="usa-grid usa-banner-inner">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
|
||
<p>An official website of the United States government</p>
|
||
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
|
||
<span class="usa-banner-button-text">Here's how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
|
||
<div class="usa-banner-guidance-gov usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The .gov means it's official.</strong>
|
||
<br />
|
||
Federal government websites often end in .gov or .mil. Before
|
||
sharing sensitive information, make sure you're on a federal
|
||
government site.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner-guidance-ssl usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The site is secure.</strong>
|
||
<br />
|
||
The <strong>https://</strong> ensures that you are connecting to the
|
||
official website and that any information you provide is encrypted
|
||
and transmitted securely.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<div class="usa-overlay"></div>
|
||
<header class="ncbi-header" role="banner" data-section="Header">
|
||
|
||
<div class="usa-grid">
|
||
<div class="usa-width-one-whole">
|
||
|
||
<div class="ncbi-header__logo">
|
||
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
|
||
</a>
|
||
</div>
|
||
|
||
<div class="ncbi-header__account">
|
||
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
|
||
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
|
||
<span class="fa fa-user" aria-hidden="true">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
|
||
<g style="fill: #fff">
|
||
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
|
||
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
|
||
</g>
|
||
</svg>
|
||
</span>
|
||
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
|
||
<span class="sr-only">Show account info</span>
|
||
</button>
|
||
</div>
|
||
|
||
<div class="ncbi-popup-anchor">
|
||
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
|
||
<div class="ncbi-popup-head">
|
||
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
|
||
<span class="fa fa-times">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
|
||
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
|
||
</svg>
|
||
</span>
|
||
<span class="usa-sr-only">Close</span></button>
|
||
<h4>Account</h4>
|
||
</div>
|
||
<div class="account-user-info">
|
||
Logged in as:<br />
|
||
<b><span class="username" id="uname_long">username</span></b>
|
||
</div>
|
||
<div class="account-links">
|
||
<ul class="usa-unstyled-list">
|
||
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
|
||
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
|
||
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
|
||
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</header>
|
||
<div role="navigation" aria-label="access keys">
|
||
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
|
||
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
|
||
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
|
||
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
|
||
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
|
||
</div>
|
||
<section data-section="Alerts">
|
||
<div class="ncbi-alerts-placeholder"></div>
|
||
</section>
|
||
</div>
|
||
|
||
<div class="header">
|
||
<!-- logo -->
|
||
<div class="res_logo" id="gene-top">
|
||
<h1 class="res_name"><a href="/medgen">MedGen</a></h1>
|
||
<h2 class="res_tagline">National Center for Biotechnology Information</h2>
|
||
</div>
|
||
<!-- SearchBar -->
|
||
<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="medgen" selected="selected" data-ac_dict="medgen_disease_name">MedGen</option><option value="clinvar">ClinVar</option><option value="pubmed" data-ac_dict="pm_related_queries_2">PubMed</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen" data-ac_dict="medgen_disease_name">MedGen</option><option value="mesh" data-ac_dict="mesh_suggestions">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed" data-ac_dict="pm_related_queries_2">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search MedGen. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'medgen_disease_name',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a name="SaveSearch" title="Click to create an email alert for this search" href="/sites/myncbi/searches/save?db=medgen&qk=43068" id="SaveSearch">Create alert</a></li><li><a sid="1" href="/medgen/limits">Limits</a></li><li><a href="/medgen/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/medgen/docs/help">Help</a></li></ul></div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
|
||
<div id="maincontent" class="col nine_col">
|
||
<div class="content">
|
||
<div>
|
||
|
||
|
||
</div>
|
||
<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="1" value="FullReport" format="" id="FullReport" checked="true" /><label for="FullReport">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="2" value="FullReport" format="text" id="FullReporttext" /><label for="FullReporttext">Summary (Text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="3" value="XML" format="text" id="XMLtext" /><label for="XMLtext">Summary (XML)</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
|
||
jQuery(document).ready( function () {
|
||
jQuery("#send_to_menu input[type='radio']").click( function () {
|
||
var selectedValue = jQuery(this).val().toLowerCase();
|
||
var selectedDiv = jQuery("#send_to_menu div." + selectedValue);
|
||
|
||
if(selectedDiv.is(":hidden")){
|
||
jQuery("#send_to_menu div.submenu:visible").slideUp();
|
||
selectedDiv.slideDown();
|
||
}
|
||
});
|
||
|
||
});
|
||
|
||
jQuery("#sendto").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu div.submenu:visible").css("display","none");
|
||
jQuery("#send_to_menu input[type='radio']:checked").attr("checked",false);
|
||
});
|
||
|
||
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FFormat" sid="1"><option value="FullReport" format="text" selected="selected">Summary (Text)</option><option value="XML" format="text">Summary (XML)</option></select></li></ul><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FileFormat" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPresentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Presentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPresentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
</div>
|
||
<div><div class="rprt full-rprt"><div class="portlet" style="border-top-style: none; margin-top: 0px; padding-top: 0px; margin-bottom: 0px; padding-left: 0.2em;">
|
||
<!--
|
||
UID=9944
|
||
ConceptID=C0025202
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Melanoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9944</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0025202</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Malignant Melanoma; Malignant Melanomas; Melanoma, Malignant; Melanomas; Melanomas, Malignant</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Malignant melanoma (372244006); Melanosarcoma (372244006); MM - malignant melanoma (1162635006); Malignant melanoma (1162635006)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related genes:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/7517">XRCC3</a>, <a target="_blank" href="/gene/7015">TERT</a>, <a target="_blank" href="/gene/6794">STK11</a>, <a target="_blank" href="/gene/4286">MITF</a>, <a target="_blank" href="/gene/4157">MC1R</a>, <a target="_blank" href="/gene/1029">CDKN2A</a>, <a target="_blank" href="/gene/1019">CDK4</a>, <a target="_blank" href="/gene/673">BRAF</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002861">HP:0002861</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005105" target="_blank">MONDO:0005105</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=411533">ORPHA411533</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Melanoma is a type of skin cancer that begins in pigment-producing cells called melanocytes. This cancer typically occurs in areas that are only occasionally sun-exposed; tumors are most commonly found on the back in men and on the legs in women. Melanoma usually occurs on the skin (cutaneous melanoma), but in about 5 percent of cases it develops in melanocytes in other tissues, including the eyes (uveal melanoma) or mucous membranes that line the body's cavities, such as the moist lining of the mouth (mucosal melanoma). Melanoma can develop at any age, but it most frequently occurs in people in their fifties to seventies and is becoming more common in teenagers and young adults.<br /><br />A large number of moles or other pigmented skin growths on the body, generally more than 25, is associated with an increased risk of developing melanoma. Melanoma is also a common feature of genetic syndromes affecting the skin such as xeroderma pigmentosum. Additionally, individuals who have previously had melanoma are nearly nine times more likely than the general population to develop melanoma again. It is estimated that about 90 percent of individuals with melanoma survive at least 5 years after being diagnosed.<br /><br />Melanoma may develop from an existing mole or other normal skin growth that becomes cancerous (malignant); however, many melanomas are new growths. Melanomas often have ragged edges and an irregular shape. They can range from a few millimeters to several centimeters across. They can also be a variety of colors: brown, black, red, pink, blue, or white.<br /><br />Most melanomas affect only the outermost layer of skin (the epidermis). If a melanoma becomes thicker and involves multiple layers of skin, it can spread to other parts of the body (metastasize). [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0025202[DISCUI]&test_type=Clinical" ref="ncbi_uid=9944">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=9944" ref="ncbi_uid=9944">V</a></span></span><span class="TLline">Melanoma</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0151779[DISCUI]&test_type=Clinical" ref="ncbi_uid=57486">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=57486" target="_blank" href="/omim/155600">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=57486" ref="ncbi_uid=57486">V</a></span></span><span class="TLline"><a href="/medgen/57486" ref="tree=GTR&ncbi_uid=57486&link_uid=57486" title="View MedGen record for 'Malignant melanoma of skin'">Malignant melanoma of skin</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1512419[DISCUI]&test_type=Clinical" ref="ncbi_uid=268851">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=268851" ref="ncbi_uid=268851">V</a></span></span><span class="TLline"><a href="/medgen/268851" ref="tree=GTR&ncbi_uid=268851&link_uid=268851" title="View MedGen record for 'Familial melanoma'">Familial melanoma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1835047[DISCUI]&test_type=Clinical" ref="ncbi_uid=320506">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=320506" target="_blank" href="/omim/155600">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=320506" ref="ncbi_uid=320506">V</a></span></span><span class="TLline"><a href="/medgen/320506" ref="tree=GTR&ncbi_uid=320506&link_uid=320506" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 1'">Melanoma, cutaneous malignant, susceptibility to, 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1835044[DISCUI]&test_type=Clinical" ref="ncbi_uid=331891">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=331891" target="_blank" href="/omim/155601">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=331891" ref="ncbi_uid=331891">V</a></span></span><span class="TLline"><a href="/medgen/331891" ref="tree=GTR&ncbi_uid=331891&link_uid=331891" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 2'">Melanoma, cutaneous malignant, susceptibility to, 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1836892[DISCUI]&test_type=Clinical" ref="ncbi_uid=373202">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=373202" target="_blank" href="/omim/123829">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=373202" ref="ncbi_uid=373202">V</a></span></span><span class="TLline"><a href="/medgen/373202" ref="tree=GTR&ncbi_uid=373202&link_uid=373202" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 3'">Melanoma, cutaneous malignant, susceptibility to, 3</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=334129" target="_blank" href="/omim/608035">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/334129" ref="tree=GTR&ncbi_uid=334129&link_uid=334129" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 4'">Melanoma, cutaneous malignant, susceptibility to, 4</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2751295[DISCUI]&test_type=Clinical" ref="ncbi_uid=416516">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=416516" target="_blank" href="/omim/155555">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=416516" ref="ncbi_uid=416516">V</a></span></span><span class="TLline"><a href="/medgen/416516" ref="tree=GTR&ncbi_uid=416516&link_uid=416516" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 5'">Melanoma, cutaneous malignant, susceptibility to, 5</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151417[DISCUI]&test_type=Clinical" ref="ncbi_uid=462767">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462767" target="_blank" href="/omim/600675">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462767" ref="ncbi_uid=462767">V</a></span></span><span class="TLline"><a href="/medgen/462767" ref="tree=GTR&ncbi_uid=462767&link_uid=462767" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 6'">Melanoma, cutaneous malignant, susceptibility to, 6</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=394200" target="_blank" href="/omim/612263">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/394200" ref="tree=GTR&ncbi_uid=394200&link_uid=394200" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 7'">Melanoma, cutaneous malignant, susceptibility to, 7</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3152204[DISCUI]&test_type=Clinical" ref="ncbi_uid=463554">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=463554" target="_blank" href="/omim/156845">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=463554" ref="ncbi_uid=463554">V</a></span></span><span class="TLline"><a href="/medgen/463554" ref="tree=GTR&ncbi_uid=463554&link_uid=463554" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 8'">Melanoma, cutaneous malignant, susceptibility to, 8</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3554574[DISCUI]&test_type=Clinical" ref="ncbi_uid=767488">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=767488" target="_blank" href="/omim/187270">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=767488" ref="ncbi_uid=767488">V</a></span></span><span class="TLline"><a href="/medgen/767488" ref="tree=GTR&ncbi_uid=767488&link_uid=767488" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 9'">Melanoma, cutaneous malignant, susceptibility to, 9</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/14297" ref="tree=MeSH" title="MedGen record for Malignant neoplastic disease">Malignant neoplastic disease</a></span><ul><li><span class="matched_ds">Melanoma</span><ul><li><span class="TLline"><a href="/medgen/64644" ref="tree=MeSH" title="MedGen record for Amelanotic melanoma">Amelanotic melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/91149" ref="tree=MeSH" title="MedGen record for Amelanotic skin melanoma">Amelanotic skin melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1374316" ref="tree=MeSH" title="MedGen record for Childhood malignant melanoma">Childhood malignant melanoma</a></span></li><li><span class="TLline"><a href="/medgen/137763" ref="tree=MeSH" title="MedGen record for Epithelioid cell melanoma">Epithelioid cell melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/234223" ref="tree=MeSH" title="MedGen record for Epithelioid cell uveal melanoma">Epithelioid cell uveal melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/232360" ref="tree=MeSH" title="MedGen record for Choroid epithelioid cell melanoma">Choroid epithelioid cell melanoma</a></span></li><li><span class="TLline"><a href="/medgen/272484" ref="tree=MeSH" title="MedGen record for Ciliary body epithelioid cell melanoma">Ciliary body epithelioid cell melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1758581" ref="tree=MeSH" title="MedGen record for Iris Epithelioid Cell Melanoma">Iris Epithelioid Cell Melanoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/9945" ref="tree=MeSH" title="MedGen record for Experimental Malignant Melanoma">Experimental Malignant Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/14002" ref="tree=MeSH" title="MedGen record for B16 Malignant Melanoma">B16 Malignant Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1011" ref="tree=MeSH" title="MedGen record for Cloudman S91 Malignant Melanoma">Cloudman S91 Malignant Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/6721" ref="tree=MeSH" title="MedGen record for Harding-Passey Malignant Melanoma">Harding-Passey Malignant Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/57443" ref="tree=MeSH" title="MedGen record for Lentigo Maligna">Lentigo Maligna</a></span></li><li><span class="TLline"><a href="/medgen/138069" ref="tree=MeSH" title="MedGen record for Malignant breast melanoma">Malignant breast melanoma</a></span></li><li><span class="TLline"><a href="/medgen/57486" ref="tree=MeSH" title="MedGen record for Malignant melanoma of skin">Malignant melanoma of skin</a></span><ul><li><span class="TLline"><a href="/medgen/87530" ref="tree=MeSH" title="MedGen record for Acral lentiginous melanoma">Acral lentiginous melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1792122" ref="tree=MeSH" title="MedGen record for Metastatic Acral Lentiginous Melanoma">Metastatic Acral Lentiginous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1779376" ref="tree=MeSH" title="MedGen record for Recurrent Acral Lentiginous Melanoma">Recurrent Acral Lentiginous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1612231" ref="tree=MeSH" title="MedGen record for Stage I Acral Lentiginous Melanoma AJCC v7">Stage I Acral Lentiginous Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1615652" ref="tree=MeSH" title="MedGen record for Stage II Acral Lentiginous Melanoma AJCC v6 and v7">Stage II Acral Lentiginous Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1619986" ref="tree=MeSH" title="MedGen record for Stage III Acral Lentiginous Melanoma AJCC v7">Stage III Acral Lentiginous Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1619912" ref="tree=MeSH" title="MedGen record for Stage IV Acral Lentiginous Melanoma AJCC v6 and v7">Stage IV Acral Lentiginous Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1713937" ref="tree=MeSH" title="MedGen record for Unresectable Acral Lentiginous Melanoma">Unresectable Acral Lentiginous Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/90780" ref="tree=MeSH" title="MedGen record for Balloon cell malignant melanoma">Balloon cell malignant melanoma</a></span></li><li><span class="TLline"><a href="/medgen/455940" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v6 Stage">Cutaneous Melanoma by AJCC v6 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1615151" ref="tree=MeSH" title="MedGen record for Stage 0 Cutaneous Melanoma AJCC v6 and v7">Stage 0 Cutaneous Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/75887" ref="tree=MeSH" title="MedGen record for Stage I Cutaneous Melanoma AJCC v6">Stage I Cutaneous Melanoma AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/1619901" ref="tree=MeSH" title="MedGen record for Stage II Cutaneous Melanoma AJCC v6 and v7">Stage II Cutaneous Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/83001" ref="tree=MeSH" title="MedGen record for Stage III Cutaneous Melanoma AJCC v6">Stage III Cutaneous Melanoma AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/1611450" ref="tree=MeSH" title="MedGen record for Stage IV Cutaneous Melanoma AJCC v6 and v7">Stage IV Cutaneous Melanoma AJCC v6 and v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/456322" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v7 Stage">Cutaneous Melanoma by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/454152" ref="tree=MeSH" title="MedGen record for Stage I Cutaneous Melanoma AJCC v7">Stage I Cutaneous Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/454153" ref="tree=MeSH" title="MedGen record for Stage III Cutaneous Melanoma AJCC v7">Stage III Cutaneous Melanoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1627083" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v8 Stage">Cutaneous Melanoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1612630" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v8 Clinical Stage">Cutaneous Melanoma by AJCC v8 Clinical Stage</a></span></li><li><span class="TLline"><a href="/medgen/1615907" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v8 Pathologic Stage">Cutaneous Melanoma by AJCC v8 Pathologic Stage</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1664542" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma of the Extremity">Cutaneous Melanoma of the Extremity</a></span><ul><li><span class="TLline"><a href="/medgen/1666275" ref="tree=MeSH" title="MedGen record for Advanced Cutaneous Melanoma of the Extremity">Advanced Cutaneous Melanoma of the Extremity</a></span></li><li><span class="TLline"><a href="/medgen/1657275" ref="tree=MeSH" title="MedGen record for Recurrent Cutaneous Melanoma of the Extremity">Recurrent Cutaneous Melanoma of the Extremity</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/268851" ref="tree=MeSH" title="MedGen record for Familial melanoma">Familial melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/924394" ref="tree=MeSH" title="MedGen record for Cutaneous Malignant Melanoma 2">Cutaneous Malignant Melanoma 2</a></span></li><li><span class="TLline"><a href="/medgen/320506" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 1">Melanoma, cutaneous malignant, susceptibility to, 1</a></span></li><li><span class="TLline"><a href="/medgen/331891" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 2">Melanoma, cutaneous malignant, susceptibility to, 2</a></span></li><li><span class="TLline"><a href="/medgen/373202" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 3">Melanoma, cutaneous malignant, susceptibility to, 3</a></span></li><li><span class="TLline"><a href="/medgen/334129" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 4">Melanoma, cutaneous malignant, susceptibility to, 4</a></span></li><li><span class="TLline"><a href="/medgen/416516" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 5">Melanoma, cutaneous malignant, susceptibility to, 5</a></span></li><li><span class="TLline"><a href="/medgen/462767" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 6">Melanoma, cutaneous malignant, susceptibility to, 6</a></span></li><li><span class="TLline"><a href="/medgen/394200" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 7">Melanoma, cutaneous malignant, susceptibility to, 7</a></span></li><li><span class="TLline"><a href="/medgen/463554" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 8">Melanoma, cutaneous malignant, susceptibility to, 8</a></span></li><li><span class="TLline"><a href="/medgen/767488" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 9">Melanoma, cutaneous malignant, susceptibility to, 9</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1719520" ref="tree=MeSH" title="MedGen record for High-CSD Melanoma">High-CSD Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/232127" ref="tree=MeSH" title="MedGen record for Desmoplastic melanoma">Desmoplastic melanoma</a></span></li><li><span class="TLline"><a href="/medgen/439437" ref="tree=MeSH" title="MedGen record for Lentigo maligna melanoma">Lentigo maligna melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/310892" ref="tree=MeSH" title="MedGen record for Invasive Cutaneous Melanoma">Invasive Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/96555" ref="tree=MeSH" title="MedGen record for Malignant Melanoma in Precancerous Melanosis">Malignant Melanoma in Precancerous Melanosis</a></span></li><li><span class="TLline"><a href="/medgen/83150" ref="tree=MeSH" title="MedGen record for Melanoma Arising from Blue Nevus">Melanoma Arising from Blue Nevus</a></span></li><li><span class="TLline"><a href="/medgen/313976" ref="tree=MeSH" title="MedGen record for Melanoma in congenital melanocytic nevus">Melanoma in congenital melanocytic nevus</a></span><ul><li><span class="TLline"><a href="/medgen/569664" ref="tree=MeSH" title="MedGen record for Melanoma Arising in Giant Congenital Nevus">Melanoma Arising in Giant Congenital Nevus</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/90782" ref="tree=MeSH" title="MedGen record for Melanoma in Junctional Nevus">Melanoma in Junctional Nevus</a></span></li><li><span class="TLline"><a href="/medgen/272113" ref="tree=MeSH" title="MedGen record for Metastatic Cutaneous Melanoma">Metastatic Cutaneous Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1728947" ref="tree=MeSH" title="MedGen record for Advanced Cutaneous Melanoma">Advanced Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1723072" ref="tree=MeSH" title="MedGen record for Locally Advanced Cutaneous Melanoma">Locally Advanced Cutaneous Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/108173" ref="tree=MeSH" title="MedGen record for Minimal Deviation Melanoma">Minimal Deviation Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/406940" ref="tree=MeSH" title="MedGen record for Nevoid Melanoma">Nevoid Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/83144" ref="tree=MeSH" title="MedGen record for Nodular malignant melanoma">Nodular malignant melanoma</a></span></li><li><span class="TLline"><a href="/medgen/233263" ref="tree=MeSH" title="MedGen record for Old Burn Scar-Related Cutaneous Melanoma">Old Burn Scar-Related Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1791543" ref="tree=MeSH" title="MedGen record for Penile Cutaneous Melanoma">Penile Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/83003" ref="tree=MeSH" title="MedGen record for Recurrent Melanoma">Recurrent Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/208941" ref="tree=MeSH" title="MedGen record for Recurrent Lentigo Maligna Melanoma">Recurrent Lentigo Maligna Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/235541" ref="tree=MeSH" title="MedGen record for Recurrent Non-Cutaneous Melanoma">Recurrent Non-Cutaneous Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1667902" ref="tree=MeSH" title="MedGen record for Refractory Cutaneous Melanoma">Refractory Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/233917" ref="tree=MeSH" title="MedGen record for Regressing Cutaneous Melanoma">Regressing Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/233100" ref="tree=MeSH" title="MedGen record for Scrotum melanoma">Scrotum melanoma</a></span></li><li><span class="TLline"><a href="/medgen/407978" ref="tree=MeSH" title="MedGen record for Signet Ring Melanoma">Signet Ring Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/234797" ref="tree=MeSH" title="MedGen record for Solar Radiation-Related Cutaneous Melanoma">Solar Radiation-Related Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1713307" ref="tree=MeSH" title="MedGen record for Spitzoid melanoma">Spitzoid melanoma</a></span></li><li><span class="TLline"><a href="/medgen/87242" ref="tree=MeSH" title="MedGen record for Superficial spreading melanoma">Superficial spreading melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1616942" ref="tree=MeSH" title="MedGen record for Stage I Low-CSD Melanoma AJCC v7">Stage I Low-CSD Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1617874" ref="tree=MeSH" title="MedGen record for Stage II Low-CSD Melanoma AJCC v7">Stage II Low-CSD Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1625334" ref="tree=MeSH" title="MedGen record for Stage III Low-CSD Melanoma AJCC v7">Stage III Low-CSD Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1626104" ref="tree=MeSH" title="MedGen record for Stage IV Low-CSD Melanoma AJCC v7">Stage IV Low-CSD Melanoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1662307" ref="tree=MeSH" title="MedGen record for Unresectable Cutaneous Melanoma">Unresectable Cutaneous Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/90784" ref="tree=MeSH" title="MedGen record for Malignant Spitz tumor">Malignant Spitz tumor</a></span><ul><li><span class="TLline"><a href="/medgen/235330" ref="tree=MeSH" title="MedGen record for Mixed cell uveal melanoma">Mixed cell uveal melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/232361" ref="tree=MeSH" title="MedGen record for Choroid mixed cell melanoma">Choroid mixed cell melanoma</a></span></li><li><span class="TLline"><a href="/medgen/234150" ref="tree=MeSH" title="MedGen record for Ciliary body mixed cell melanoma">Ciliary body mixed cell melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1756478" ref="tree=MeSH" title="MedGen record for Iris Mixed Cell Melanoma">Iris Mixed Cell Melanoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/235317" ref="tree=MeSH" title="MedGen record for Melanomatosis">Melanomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/226843" ref="tree=MeSH" title="MedGen record for Meningeal melanomatosis">Meningeal melanomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83002" ref="tree=MeSH" title="MedGen record for Metastatic melanoma">Metastatic melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1663701" ref="tree=MeSH" title="MedGen record for Advanced Melanoma">Advanced Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1793140" ref="tree=MeSH" title="MedGen record for Advanced Non-Cutaneous Melanoma">Advanced Non-Cutaneous Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1660326" ref="tree=MeSH" title="MedGen record for Locally Advanced Melanoma">Locally Advanced Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1751807" ref="tree=MeSH" title="MedGen record for Locally Advanced Non-Cutaneous Melanoma">Locally Advanced Non-Cutaneous Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1623731" ref="tree=MeSH" title="MedGen record for Melanoma Metastatic in the Central Nervous System">Melanoma Metastatic in the Central Nervous System</a></span><ul><li><span class="TLline"><a href="/medgen/1791970" ref="tree=MeSH" title="MedGen record for Melanoma Metastatic in the Brain">Melanoma Metastatic in the Brain</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1667560" ref="tree=MeSH" title="MedGen record for Melanoma of Unknown Primary">Melanoma of Unknown Primary</a></span></li><li><span class="TLline"><a href="/medgen/277365" ref="tree=MeSH" title="MedGen record for Metastatic Non-Cutaneous Melanoma">Metastatic Non-Cutaneous Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1715092" ref="tree=MeSH" title="MedGen record for Metastatic Mucosal Melanoma">Metastatic Mucosal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1732756" ref="tree=MeSH" title="MedGen record for Metastatic Ocular Melanoma">Metastatic Ocular Melanoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/233761" ref="tree=MeSH" title="MedGen record for Non-cutaneous melanoma">Non-cutaneous melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/232334" ref="tree=MeSH" title="MedGen record for Central Nervous System Melanoma">Central Nervous System Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/232664" ref="tree=MeSH" title="MedGen record for Intracranial Melanoma">Intracranial Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/272793" ref="tree=MeSH" title="MedGen record for Leptomeningeal melanoma">Leptomeningeal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/236837" ref="tree=MeSH" title="MedGen record for Spinal cord melanoma">Spinal cord melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/353869" ref="tree=MeSH" title="MedGen record for Lung Melanoma">Lung Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/138060" ref="tree=MeSH" title="MedGen record for Malignant conjunctival melanoma">Malignant conjunctival melanoma</a></span></li><li><span class="TLline"><a href="/medgen/138061" ref="tree=MeSH" title="MedGen record for Malignant cornea melanoma">Malignant cornea melanoma</a></span></li><li><span class="TLline"><a href="/medgen/857816" ref="tree=MeSH" title="MedGen record for Mucosal melanoma">Mucosal melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/234305" ref="tree=MeSH" title="MedGen record for Digestive system melanoma">Digestive system melanoma</a></span></li><li><span class="TLline"><a href="/medgen/220417" ref="tree=MeSH" title="MedGen record for Mucosal Lentiginous Melanoma">Mucosal Lentiginous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1791478" ref="tree=MeSH" title="MedGen record for Mucosal Melanoma of the Genitourinary System">Mucosal Melanoma of the Genitourinary System</a></span></li><li><span class="TLline"><a href="/medgen/1612951" ref="tree=MeSH" title="MedGen record for Mucosal Melanoma of the Head and Neck">Mucosal Melanoma of the Head and Neck</a></span></li><li><span class="TLline"><a href="/medgen/1695508" ref="tree=MeSH" title="MedGen record for Mucosal Nodular Melanoma">Mucosal Nodular Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1730067" ref="tree=MeSH" title="MedGen record for Recurrent Mucosal Melanoma">Recurrent Mucosal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1793139" ref="tree=MeSH" title="MedGen record for Refractory Mucosal Melanoma">Refractory Mucosal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1711109" ref="tree=MeSH" title="MedGen record for Unresectable Mucosal Melanoma">Unresectable Mucosal Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1790038" ref="tree=MeSH" title="MedGen record for Ovarian melanoma">Ovarian melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1704168" ref="tree=MeSH" title="MedGen record for Prostate Melanoma">Prostate Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1747627" ref="tree=MeSH" title="MedGen record for Refractory Non-Cutaneous Melanoma">Refractory Non-Cutaneous Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1775859" ref="tree=MeSH" title="MedGen record for Refractory Ocular Melanoma">Refractory Ocular Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/277586" ref="tree=MeSH" title="MedGen record for Regressing Non-Cutaneous Melanoma">Regressing Non-Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/163431" ref="tree=MeSH" title="MedGen record for Retinal melanoma">Retinal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/65077" ref="tree=MeSH" title="MedGen record for Uveal melanoma">Uveal melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1643389" ref="tree=MeSH" title="MedGen record for Choroidal and Ciliary Body Melanoma by AJCC v8 Stage">Choroidal and Ciliary Body Melanoma by AJCC v8 Stage</a></span></li><li><span class="TLline"><a href="/medgen/138064" ref="tree=MeSH" title="MedGen record for Choroidal melanoma">Choroidal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/138062" ref="tree=MeSH" title="MedGen record for Ciliary body melanoma">Ciliary body melanoma</a></span></li><li><span class="TLline"><a href="/medgen/76016" ref="tree=MeSH" title="MedGen record for Intermediate cell type uveal melanoma">Intermediate cell type uveal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/87559" ref="tree=MeSH" title="MedGen record for Iris melanoma">Iris melanoma</a></span></li><li><span class="TLline"><a href="/medgen/124525" ref="tree=MeSH" title="MedGen record for Medium/large size posterior uveal melanoma">Medium/large size posterior uveal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1649122" ref="tree=MeSH" title="MedGen record for Metastatic Uveal Melanoma">Metastatic Uveal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1669717" ref="tree=MeSH" title="MedGen record for Necrotic uveal melanoma">Necrotic uveal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/75885" ref="tree=MeSH" title="MedGen record for Recurrent Uveal Melanoma">Recurrent Uveal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1771214" ref="tree=MeSH" title="MedGen record for Refractory Uveal Melanoma">Refractory Uveal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/75883" ref="tree=MeSH" title="MedGen record for Small size posterior uveal melanoma">Small size posterior uveal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/76015" ref="tree=MeSH" title="MedGen record for Spindle cell intraocular melanoma">Spindle cell intraocular melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1726417" ref="tree=MeSH" title="MedGen record for Unresectable Uveal Melanoma">Unresectable Uveal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1631926" ref="tree=MeSH" title="MedGen record for Uveal Melanoma by AJCC v7 Stage">Uveal Melanoma by AJCC v7 Stage</a></span></li><li><span class="TLline"><a href="/medgen/819941" ref="tree=MeSH" title="MedGen record for Uveal Melanoma by Gene Expression Profile">Uveal Melanoma by Gene Expression Profile</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/107846" ref="tree=MeSH" title="MedGen record for Ocular melanoma">Ocular melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/90937" ref="tree=MeSH" title="MedGen record for Eyelid melanoma">Eyelid melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1781892" ref="tree=MeSH" title="MedGen record for Lacrimal Drainage System Melanoma">Lacrimal Drainage System Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/75884" ref="tree=MeSH" title="MedGen record for Ocular melanoma with extraocular extension">Ocular melanoma with extraocular extension</a></span></li><li><span class="TLline"><a href="/medgen/1759355" ref="tree=MeSH" title="MedGen record for Recurrent Ocular Melanoma">Recurrent Ocular Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/857683" ref="tree=MeSH" title="MedGen record for Orbital Melanoma">Orbital Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1697024" ref="tree=MeSH" title="MedGen record for Penile Melanoma">Penile Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1791542" ref="tree=MeSH" title="MedGen record for Penile Mucosal Melanoma">Penile Mucosal Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1643370" ref="tree=MeSH" title="MedGen record for Refractory Melanoma">Refractory Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/90781" ref="tree=MeSH" title="MedGen record for Regressing Melanoma">Regressing Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/83147" ref="tree=MeSH" title="MedGen record for Spindle cell melanoma">Spindle cell melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/83148" ref="tree=MeSH" title="MedGen record for Type A Spindle Cell Melanoma">Type A Spindle Cell Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/234808" ref="tree=MeSH" title="MedGen record for Uveal Spindle Cell Type A Melanoma">Uveal Spindle Cell Type A Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83149" ref="tree=MeSH" title="MedGen record for Type B Spindle Cell Melanoma">Type B Spindle Cell Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/236839" ref="tree=MeSH" title="MedGen record for Uveal Spindle Cell Type B Melanoma">Uveal Spindle Cell Type B Melanoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1662618" ref="tree=MeSH" title="MedGen record for Unresectable Melanoma">Unresectable Melanoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_75550"><div><strong>DE SANCTIS-CACCHIONE SYNDROME</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75550</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0265201</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare autosomal recessive inherited syndrome. It is characterized by xeroderma pigmentosum, mental retardation, dwarfism, hypogonadism, and neurologic abnormalities.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75550">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_82775"><div><strong>Xeroderma pigmentosum group A</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82775</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268135</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82775">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_75656"><div><strong>Xeroderma pigmentosum, group D</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75656</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268138</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75656">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_154259"><div><strong>Neurocutaneous melanocytosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>154259</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0544862</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Neurocutaneous melanosis, or neuromelanosis, is characterized by the presence of melanin-producing cells within the brain parenchyma or leptomeninges, which may lead to clinically apparent neurologic signs and symptoms, such as seizures. Other neurologic abnormalities, including hydrocephalus, arachnoid cysts, tumors, and syringomyelia, may also occur. The disorder is a rare but severe manifestation of congenital melanocytic nevus syndrome (CMNS; 137550). Some patients with neurocutaneous melanosis or CMNS may develop malignant melanoma. The incidence of neurologic involvement, development of malignant melanoma, and death is significantly associated with the projected adult size of the largest congenital melanocytic nevus, particularly those greater than 40 cm (summary by Kinsler et al., 2008; Kinsler et al., 2013).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/154259">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_325450"><div><strong>Melanoma-pancreatic cancer syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325450</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838547</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Melanoma-pancreatic cancer syndrome is an inherited cancer predisposition syndrome in which mutation carriers have an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer (summary by Harinck et al., 2012). For background and phenotypic information on malignant melanoma and pancreatic cancer, see 155600 and 260350, respectively.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/325450">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_341219"><div><strong>Xeroderma pigmentosum, group E</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341219</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1848411</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/341219">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767488"><div><strong>Melanoma, cutaneous malignant, susceptibility to, 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767488</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554574</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). For a discussion of genetic heterogeneity of malignant melanoma, see 155600.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767488">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_862913"><div><strong>Tumor predisposition syndrome 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>862913</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014476</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">POT1 tumor predisposition (POT1-TPD) is characterized by an increased lifetime risk for multiple cutaneous melanomas, sarcomas (particularly cardiac angiosarcomas), chronic lymphocytic leukemia (CLL), and gliomas. Additional solid tumors and hematologic neoplasms (e.g., thyroid cancer) have been reported in individuals with POT1-TPD. The age of onset for first primary cutaneous melanoma ranges from 15 to 80 years. The majority of POT1-associated cancers are diagnosed in adulthood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/862913">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1684838"><div><strong>Pancreatic cancer, susceptibility to, 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684838</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5231459</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Susceptibility to pancreatic ductal adenocarcinoma (PDAC) may be conferred by mutation in RABL3. Other cancers, including melanoma, breast cancer, and colon cancer, have been reported in RABL3 mutation-carrying individuals, with or without PDAC (Nissim et al., 2019). For background, phenotypic description, and a discussion of genetic heterogeneity of pancreatic carcinoma, see 260350.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1684838">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1823990"><div><strong>Dyskeratosis congenita, digenic</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823990</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774217</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Digenic dyskeratosis congenita (DKCD) is characterized clinically by a combination of mucocutaneous features including abnormal skin pigmentation, nail dystrophy, thin hair, and oral leukoplakia. Some patients may have evidence of bone marrow failure, manifest as immune defects such as recurrent infections or hypogammaglobulinemia. Telomeres are shortened in patient cells. Individuals with DKCD may show severe adverse reactions to treatment with 5-FU (Tummala et al., 2022). For a discussion of genetic heterogeneity of dyskeratosis congenita, see DKCA1 (127550).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1823990">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75550" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">DE SANCTIS-CACCHIONE SYNDROME</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823990" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dyskeratosis congenita, digenic</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767488" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, cutaneous malignant, susceptibility to, 9</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325450" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma-pancreatic cancer syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_154259" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurocutaneous melanocytosis</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (10)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684838" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pancreatic cancer, susceptibility to, 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_862913" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tumor predisposition syndrome 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82775" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Xeroderma pigmentosum group A</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75656" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Xeroderma pigmentosum, group D</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341219" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Xeroderma pigmentosum, group E</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37658764">International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuan EC,
|
||
Wang EW,
|
||
Adappa ND,
|
||
Beswick DM,
|
||
London NR Jr,
|
||
Su SY,
|
||
Wang MB,
|
||
Abuzeid WM,
|
||
Alexiev B,
|
||
Alt JA,
|
||
Antognoni P,
|
||
Alonso-Basanta M,
|
||
Batra PS,
|
||
Bhayani M,
|
||
Bell D,
|
||
Bernal-Sprekelsen M,
|
||
Betz CS,
|
||
Blay JY,
|
||
Bleier BS,
|
||
Bonilla-Velez J,
|
||
Callejas C,
|
||
Carrau RL,
|
||
Casiano RR,
|
||
Castelnuovo P,
|
||
Chandra RK,
|
||
Chatzinakis V,
|
||
Chen SB,
|
||
Chiu AG,
|
||
Choby G,
|
||
Chowdhury NI,
|
||
Citardi MJ,
|
||
Cohen MA,
|
||
Dagan R,
|
||
Dalfino G,
|
||
Dallan I,
|
||
Dassi CS,
|
||
de Almeida J,
|
||
Dei Tos AP,
|
||
DelGaudio JM,
|
||
Ebert CS,
|
||
El-Sayed IH,
|
||
Eloy JA,
|
||
Evans JJ,
|
||
Fang CH,
|
||
Farrell NF,
|
||
Ferrari M,
|
||
Fischbein N,
|
||
Folbe A,
|
||
Fokkens WJ,
|
||
Fox MG,
|
||
Lund VJ,
|
||
Gallia GL,
|
||
Gardner PA,
|
||
Geltzeiler M,
|
||
Georgalas C,
|
||
Getz AE,
|
||
Govindaraj S,
|
||
Gray ST,
|
||
Grayson JW,
|
||
Gross BA,
|
||
Grube JG,
|
||
Guo R,
|
||
Ha PK,
|
||
Halderman AA,
|
||
Hanna EY,
|
||
Harvey RJ,
|
||
Hernandez SC,
|
||
Holtzman AL,
|
||
Hopkins C,
|
||
Huang Z,
|
||
Huang Z,
|
||
Humphreys IM,
|
||
Hwang PH,
|
||
Iloreta AM,
|
||
Ishii M,
|
||
Ivan ME,
|
||
Jafari A,
|
||
Kennedy DW,
|
||
Khan M,
|
||
Kimple AJ,
|
||
Kingdom TT,
|
||
Knisely A,
|
||
Kuo YJ,
|
||
Lal D,
|
||
Lamarre ED,
|
||
Lan MY,
|
||
Le H,
|
||
Lechner M,
|
||
Lee NY,
|
||
Lee JK,
|
||
Lee VH,
|
||
Levine CG,
|
||
Lin JC,
|
||
Lin DT,
|
||
Lobo BC,
|
||
Locke T,
|
||
Luong AU,
|
||
Magliocca KR,
|
||
Markovic SN,
|
||
Matnjani G,
|
||
McKean EL,
|
||
Meço C,
|
||
Mendenhall WM,
|
||
Michel L,
|
||
Na'ara S,
|
||
Nicolai P,
|
||
Nuss DW,
|
||
Nyquist GG,
|
||
Oakley GM,
|
||
Omura K,
|
||
Orlandi RR,
|
||
Otori N,
|
||
Papagiannopoulos P,
|
||
Patel ZM,
|
||
Pfister DG,
|
||
Phan J,
|
||
Psaltis AJ,
|
||
Rabinowitz MR,
|
||
Ramanathan M Jr,
|
||
Rimmer R,
|
||
Rosen MR,
|
||
Sanusi O,
|
||
Sargi ZB,
|
||
Schafhausen P,
|
||
Schlosser RJ,
|
||
Sedaghat AR,
|
||
Senior BA,
|
||
Shrivastava R,
|
||
Sindwani R,
|
||
Smith TL,
|
||
Smith KA,
|
||
Snyderman CH,
|
||
Solares CA,
|
||
Sreenath SB,
|
||
Stamm A,
|
||
Stölzel K,
|
||
Sumer B,
|
||
Surda P,
|
||
Tajudeen BA,
|
||
Thompson LDR,
|
||
Thorp BD,
|
||
Tong CCL,
|
||
Tsang RK,
|
||
Turner JH,
|
||
Turri-Zanoni M,
|
||
Udager AM,
|
||
van Zele T,
|
||
VanKoevering K,
|
||
Welch KC,
|
||
Wise SK,
|
||
Witterick IJ,
|
||
Won TB,
|
||
Wong SN,
|
||
Woodworth BA,
|
||
Wormald PJ,
|
||
Yao WC,
|
||
Yeh CF,
|
||
Zhou B,
|
||
Palmer JN</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2024 Feb;14(2):149-608.
|
||
Epub 2024 Jan 2
|
||
doi: 10.1002/alr.23262.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37658764" target="_blank">37658764</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35570085">European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garbe C,
|
||
Amaral T,
|
||
Peris K,
|
||
Hauschild A,
|
||
Arenberger P,
|
||
Basset-Seguin N,
|
||
Bastholt L,
|
||
Bataille V,
|
||
Del Marmol V,
|
||
Dréno B,
|
||
Fargnoli MC,
|
||
Forsea AM,
|
||
Grob JJ,
|
||
Höller C,
|
||
Kaufmann R,
|
||
Kelleners-Smeets N,
|
||
Lallas A,
|
||
Lebbé C,
|
||
Lytvynenko B,
|
||
Malvehy J,
|
||
Moreno-Ramirez D,
|
||
Nathan P,
|
||
Pellacani G,
|
||
Saiag P,
|
||
Stratigos AJ,
|
||
Van Akkooi ACJ,
|
||
Vieira R,
|
||
Zalaudek I,
|
||
Lorigan P;
|
||
European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)</span><br />
|
||
<span class="medgenPMjournal">Eur J Cancer</span>
|
||
2022 Jul;170:236-255.
|
||
Epub 2022 May 12
|
||
doi: 10.1016/j.ejca.2022.03.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35570085" target="_blank">35570085</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31366280">Current state of melanoma diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Davis LE,
|
||
Shalin SC,
|
||
Tackett AJ</span><br />
|
||
<span class="medgenPMjournal">Cancer Biol Ther</span>
|
||
2019;20(11):1366-1379.
|
||
Epub 2019 Aug 1
|
||
doi: 10.1080/15384047.2019.1640032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31366280" target="_blank">31366280</a><a href="/pmc/articles/PMC6804807" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22melanoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (5544)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng14" target="_blank">UK NICE Guideline NG14, Melanoma: assessment and management, 2022</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389333">Genetics of Skin Cancer (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389333" target="_blank">26389333</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389258">Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389258" target="_blank">26389258</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36867424">What Is Melanoma?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang JY,
|
||
Wang EB,
|
||
Swetter SM</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Mar 21;329(11):948.
|
||
doi: 10.1001/jama.2022.24888.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36867424" target="_blank">36867424</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36719425">Melanoma in pregnancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Czeyda-Pommersheim F,
|
||
Kluger H,
|
||
Langdon J,
|
||
Menias C,
|
||
VanBuren W,
|
||
Leventhal J,
|
||
Baumann R Jr,
|
||
Revzin M</span><br />
|
||
<span class="medgenPMjournal">Abdom Radiol (NY)</span>
|
||
2023 May;48(5):1740-1751.
|
||
Epub 2023 Jan 31
|
||
doi: 10.1007/s00261-022-03796-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36719425" target="_blank">36719425</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33982546">Histopathologic classification and prognostic factors of melanoma: a 2021 update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bobos M</span><br />
|
||
<span class="medgenPMjournal">Ital J Dermatol Venerol</span>
|
||
2021 Jun;156(3):300-321.
|
||
Epub 2021 May 13
|
||
doi: 10.23736/S2784-8671.21.06958-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33982546" target="_blank">33982546</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27465194">Malignant Melanoma: Beyond the Basics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pavri SN,
|
||
Clune J,
|
||
Ariyan S,
|
||
Narayan D</span><br />
|
||
<span class="medgenPMjournal">Plast Reconstr Surg</span>
|
||
2016 Aug;138(2):330e-340e.
|
||
doi: 10.1097/PRS.0000000000002367.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27465194" target="_blank">27465194</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25398793">Melanoma: epidemiology, risk factors, pathogenesis, diagnosis and classification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rastrelli M,
|
||
Tropea S,
|
||
Rossi CR,
|
||
Alaibac M</span><br />
|
||
<span class="medgenPMjournal">In Vivo</span>
|
||
2014 Nov-Dec;28(6):1005-11.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25398793" target="_blank">25398793</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Melanoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33915)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36867424">What Is Melanoma?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang JY,
|
||
Wang EB,
|
||
Swetter SM</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Mar 21;329(11):948.
|
||
doi: 10.1001/jama.2022.24888.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36867424" target="_blank">36867424</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34023098">PRAME Immunohistochemistry as an Ancillary Test for the Assessment of Melanocytic Lesions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lezcano C,
|
||
Jungbluth AA,
|
||
Busam KJ</span><br />
|
||
<span class="medgenPMjournal">Surg Pathol Clin</span>
|
||
2021 Jun;14(2):165-175.
|
||
Epub 2021 Apr 28
|
||
doi: 10.1016/j.path.2021.01.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34023098" target="_blank">34023098</a><a href="/pmc/articles/PMC8152939" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33982546">Histopathologic classification and prognostic factors of melanoma: a 2021 update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bobos M</span><br />
|
||
<span class="medgenPMjournal">Ital J Dermatol Venerol</span>
|
||
2021 Jun;156(3):300-321.
|
||
Epub 2021 May 13
|
||
doi: 10.23736/S2784-8671.21.06958-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33982546" target="_blank">33982546</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27465194">Malignant Melanoma: Beyond the Basics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pavri SN,
|
||
Clune J,
|
||
Ariyan S,
|
||
Narayan D</span><br />
|
||
<span class="medgenPMjournal">Plast Reconstr Surg</span>
|
||
2016 Aug;138(2):330e-340e.
|
||
doi: 10.1097/PRS.0000000000002367.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27465194" target="_blank">27465194</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25398793">Melanoma: epidemiology, risk factors, pathogenesis, diagnosis and classification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rastrelli M,
|
||
Tropea S,
|
||
Rossi CR,
|
||
Alaibac M</span><br />
|
||
<span class="medgenPMjournal">In Vivo</span>
|
||
2014 Nov-Dec;28(6):1005-11.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25398793" target="_blank">25398793</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Melanoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (36105)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34999237">Metastatic uveal melanoma: The final frontier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rantala ES,
|
||
Hernberg MM,
|
||
Piperno-Neumann S,
|
||
Grossniklaus HE,
|
||
Kivelä TT</span><br />
|
||
<span class="medgenPMjournal">Prog Retin Eye Res</span>
|
||
2022 Sep;90:101041.
|
||
Epub 2022 Jan 6
|
||
doi: 10.1016/j.preteyeres.2022.101041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34999237" target="_blank">34999237</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34098219">NRAS mutant melanoma: Towards better therapies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Randic T,
|
||
Kozar I,
|
||
Margue C,
|
||
Utikal J,
|
||
Kreis S</span><br />
|
||
<span class="medgenPMjournal">Cancer Treat Rev</span>
|
||
2021 Sep;99:102238.
|
||
Epub 2021 May 29
|
||
doi: 10.1016/j.ctrv.2021.102238.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34098219" target="_blank">34098219</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33002195">Neoadjuvant immunotherapy for melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee AY,
|
||
Brady MS</span><br />
|
||
<span class="medgenPMjournal">J Surg Oncol</span>
|
||
2021 Mar;123(3):782-788.
|
||
Epub 2020 Oct 1
|
||
doi: 10.1002/jso.26229.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33002195" target="_blank">33002195</a><a href="/pmc/articles/PMC8366312" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32273608">Learning from clinical trials of neoadjuvant checkpoint blockade.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Versluis JM,
|
||
Long GV,
|
||
Blank CU</span><br />
|
||
<span class="medgenPMjournal">Nat Med</span>
|
||
2020 Apr;26(4):475-484.
|
||
Epub 2020 Apr 9
|
||
doi: 10.1038/s41591-020-0829-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32273608" target="_blank">32273608</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22781695">Oncolytic virotherapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Russell SJ,
|
||
Peng KW,
|
||
Bell JC</span><br />
|
||
<span class="medgenPMjournal">Nat Biotechnol</span>
|
||
2012 Jul 10;30(7):658-70.
|
||
doi: 10.1038/nbt.2287.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22781695" target="_blank">22781695</a><a href="/pmc/articles/PMC3888062" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Melanoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (31861)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32940362">Cancer statistics for adolescents and young adults, 2020.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller KD,
|
||
Fidler-Benaoudia M,
|
||
Keegan TH,
|
||
Hipp HS,
|
||
Jemal A,
|
||
Siegel RL</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2020 Nov;70(6):443-459.
|
||
Epub 2020 Sep 17
|
||
doi: 10.3322/caac.21637.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32940362" target="_blank">32940362</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31912902">Cancer statistics, 2020.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siegel RL,
|
||
Miller KD,
|
||
Jemal A</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2020 Jan;70(1):7-30.
|
||
Epub 2020 Jan 8
|
||
doi: 10.3322/caac.21590.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31912902" target="_blank">31912902</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31184787">Cancer treatment and survivorship statistics, 2019.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller KD,
|
||
Nogueira L,
|
||
Mariotto AB,
|
||
Rowland JH,
|
||
Yabroff KR,
|
||
Alfano CM,
|
||
Jemal A,
|
||
Kramer JL,
|
||
Siegel RL</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2019 Sep;69(5):363-385.
|
||
Epub 2019 Jun 11
|
||
doi: 10.3322/caac.21565.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31184787" target="_blank">31184787</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30350310">Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferlay J,
|
||
Colombet M,
|
||
Soerjomataram I,
|
||
Mathers C,
|
||
Parkin DM,
|
||
Piñeros M,
|
||
Znaor A,
|
||
Bray F</span><br />
|
||
<span class="medgenPMjournal">Int J Cancer</span>
|
||
2019 Apr 15;144(8):1941-1953.
|
||
Epub 2018 Dec 6
|
||
doi: 10.1002/ijc.31937.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30350310" target="_blank">30350310</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8723827">Vulvar melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Panizzon RG</span><br />
|
||
<span class="medgenPMjournal">Semin Dermatol</span>
|
||
1996 Mar;15(1):67-70.
|
||
doi: 10.1016/s1085-5629(96)80021-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8723827" target="_blank">8723827</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Melanoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (31328)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32482311">Interpretation of the Complex Melanoma Pathology Report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Crompton JG,
|
||
Busam KJ,
|
||
Bartlett EK</span><br />
|
||
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
|
||
2020 Jul;29(3):327-338.
|
||
doi: 10.1016/j.soc.2020.02.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32482311" target="_blank">32482311</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27349977">Emerging biomarkers as predictors to anti-PD1/PD-L1 therapies in advanced melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Loo K,
|
||
Daud A</span><br />
|
||
<span class="medgenPMjournal">Immunotherapy</span>
|
||
2016 Jun;8(7):775-84.
|
||
doi: 10.2217/imt-2016-0039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27349977" target="_blank">27349977</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25649904">Ocular cytopathology: A primer for the generalist.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Laver NM</span><br />
|
||
<span class="medgenPMjournal">Semin Diagn Pathol</span>
|
||
2015 Jul;32(4):311-22.
|
||
Epub 2014 Dec 19
|
||
doi: 10.1053/j.semdp.2014.12.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25649904" target="_blank">25649904</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23961515">Basic dermoscopy for the resident.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pickert A</span><br />
|
||
<span class="medgenPMjournal">Cutis</span>
|
||
2012 Jan;89(1):E1-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23961515" target="_blank">23961515</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9389970">The dysplastic naevus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mooi WJ</span><br />
|
||
<span class="medgenPMjournal">J Clin Pathol</span>
|
||
1997 Sep;50(9):711-5.
|
||
doi: 10.1136/jcp.50.9.711.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9389970" target="_blank">9389970</a><a href="/pmc/articles/PMC500166" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Melanoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28225)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37210654">Melanoma in children: A systematic review and individual patient meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pampena R,
|
||
Piccolo V,
|
||
Muscianese M,
|
||
Kyrgidis A,
|
||
Lai M,
|
||
Russo T,
|
||
Briatico G,
|
||
Di Brizzi EV,
|
||
Cascone G,
|
||
Pellerone S,
|
||
Longo C,
|
||
Moscarella E,
|
||
Argenziano G</span><br />
|
||
<span class="medgenPMjournal">J Eur Acad Dermatol Venereol</span>
|
||
2023 Sep;37(9):1758-1776.
|
||
Epub 2023 Jun 2
|
||
doi: 10.1111/jdv.19220.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37210654" target="_blank">37210654</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37196485">Activity and safety of first-line treatments for advanced melanoma: A network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boutros A,
|
||
Tanda ET,
|
||
Croce E,
|
||
Catalano F,
|
||
Ceppi M,
|
||
Bruzzone M,
|
||
Cecchi F,
|
||
Arecco L,
|
||
Fraguglia M,
|
||
Pronzato P,
|
||
Genova C,
|
||
Del Mastro L,
|
||
Lambertini M,
|
||
Spagnolo F</span><br />
|
||
<span class="medgenPMjournal">Eur J Cancer</span>
|
||
2023 Jul;188:64-79.
|
||
Epub 2023 Apr 24
|
||
doi: 10.1016/j.ejca.2023.04.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37196485" target="_blank">37196485</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35526566">Current State of Skin Cancer Prevention: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alonso-Belmonte C,
|
||
Montero-Vilchez T,
|
||
Arias-Santiago S,
|
||
Buendía-Eisman A</span><br />
|
||
<span class="medgenPMjournal">Actas Dermosifiliogr</span>
|
||
2022 Sep;113(8):781-791.
|
||
Epub 2022 May 5
|
||
doi: 10.1016/j.ad.2022.04.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35526566" target="_blank">35526566</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33325988">UV Exposure and the Risk of Cutaneous Melanoma in Skin of Color: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lopes FCPS,
|
||
Sleiman MG,
|
||
Sebastian K,
|
||
Bogucka R,
|
||
Jacobs EA,
|
||
Adamson AS</span><br />
|
||
<span class="medgenPMjournal">JAMA Dermatol</span>
|
||
2021 Feb 1;157(2):213-219.
|
||
doi: 10.1001/jamadermatol.2020.4616.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33325988" target="_blank">33325988</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29620003">Use of sunscreen and risk of melanoma and non-melanoma skin cancer: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Silva ESD,
|
||
Tavares R,
|
||
Paulitsch FDS,
|
||
Zhang L</span><br />
|
||
<span class="medgenPMjournal">Eur J Dermatol</span>
|
||
2018 Apr 1;28(2):186-201.
|
||
doi: 10.1684/ejd.2018.3251.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29620003" target="_blank">29620003</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Melanoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1163)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0025202%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (36)</a></li>
|
||
<li><a href="/gtr/tests?term=C0025202%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0025202%5bDISCUI%5d&filter=method%3A1%5F3" target="_blank">Immunohistochemistry (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0025202%5bDISCUI%5d&filter=method%3A2%5F12" target="_blank">Microsatellite instability testing (MSI) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0025202%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0025202%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (6)</a></li>
|
||
<li><a href="/gtr/tests?term=C0025202%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (49)</a></li>
|
||
<li><a href="/gtr/tests?term=C0025202%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (23)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0025202%5bDISCUI%5d" target="_blank">See all (80)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=411533" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Melanoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22melanoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Melanoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng14">NICE, 2022</a><div>UK NICE Guideline NG14, Melanoma: assessment and management, 2022</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Melanoma" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/melanoma" target="_blank">MedlinePlusGenetics (GHR)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Melanoma" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Melanoma%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=9944" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0025202[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0025202[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=9944" ref="log$=recordlinks">MeSH</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=9944" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=9944" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67cd351af4a390645ed735cb">Melanoma</a>
|
||
<div class="ralinkpop offscreen_noflow">Melanoma<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67cd3517b15b832ebc8c2ca2">C0025202[conceptid] <span class="number">(1)</span></a>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67cd3517b15b832ebc8c2962">C4479655[trait identifier] AND "OMIM"[submitter] <span class="number">(2)</span></a>
|
||
<div class="tertiary">ClinVar</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67cd3516b15b832ebc8c22d9">C4310738[trait identifier] AND "OMIM"[submitter] <span class="number">(9)</span></a>
|
||
<div class="tertiary">ClinVar</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67cd3515a68b6b5afc02ce99">C4225188[trait identifier] AND "OMIM"[submitter] <span class="number">(3)</span></a>
|
||
<div class="tertiary">ClinVar</div>
|
||
</li>
|
||
</ul>
|
||
<p class="HTOn">Your browsing activity is empty.</p>
|
||
<p class="HTOff">Activity recording is turned off.</p>
|
||
<p id="turnOn" class="HTOff">
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
|
||
</p>
|
||
<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="NCBIFooter_dynamic">
|
||
<!--<component id="NCBIBreadcrumbs"/>
|
||
<component id="NCBIHelpDesk"/>-->
|
||
<noscript><img alt="" src="/stat?jsdisabled=true&ncbi_app=entrez&ncbi_db=medgen&ncbi_pdid=FullReport&ncbi_phid=CE8BE6E47CD255C10000000000D900AF" /></noscript>
|
||
</div>
|
||
|
||
<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer/">
|
||
<section class="icon-section">
|
||
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
|
||
<div class="grid-container container">
|
||
<div class="icon-section_container">
|
||
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1008">
|
||
<path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path>
|
||
</g>
|
||
</svg>
|
||
</a>
|
||
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>Facebook</title>
|
||
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>LinkedIn</title>
|
||
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<defs>
|
||
<style>
|
||
.cls-11,
|
||
.cls-12 {
|
||
fill: #737373;
|
||
}
|
||
|
||
.cls-11 {
|
||
fill-rule: evenodd;
|
||
}
|
||
</style>
|
||
</defs>
|
||
<title>GitHub</title>
|
||
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
|
||
</path>
|
||
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
|
||
</path>
|
||
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
|
||
</path>
|
||
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
|
||
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
|
||
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
|
||
<defs><style>.cls-1{fill:#737373;}</style></defs>
|
||
<title>NCBI Insights Blog</title>
|
||
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
|
||
</svg>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
<section class="container-fluid bg-primary">
|
||
<div class="container pt-5">
|
||
<div class="row mt-3">
|
||
<div class="col-lg-3 col-12">
|
||
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
|
||
<ul class="list-inline social_media">
|
||
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1009" clip-path="url(#clip0_65276_3946)">
|
||
<path id="Vector_Twitter" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
<path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_65276_3946">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Facebook</title>
|
||
<g id="Facebook" clip-path="url(#clip0_1717_1086)">
|
||
<path id="Vector_Facebook" d="M15.1147 29.1371C15.1147 29.0822 15.1147 29.0296 15.1147 28.9747V18.9414H11.8183C11.6719 18.9414 11.6719 18.9414 11.6719 18.8018C11.6719 17.5642 11.6719 16.3289 11.6719 15.0937C11.6719 14.9793 11.7062 14.9518 11.816 14.9518C12.8683 14.9518 13.9206 14.9518 14.9751 14.9518H15.1215V14.8329C15.1215 13.8057 15.1215 12.774 15.1215 11.7492C15.1274 10.9262 15.3148 10.1146 15.6706 9.37241C16.1301 8.38271 16.9475 7.60378 17.9582 7.19235C18.6492 6.90525 19.3923 6.76428 20.1405 6.7783C21.0029 6.79202 21.8653 6.83091 22.7278 6.86065C22.8879 6.86065 23.048 6.89496 23.2082 6.90182C23.2974 6.90182 23.3271 6.94071 23.3271 7.02993C23.3271 7.54235 23.3271 8.05477 23.3271 8.5649C23.3271 9.16882 23.3271 9.77274 23.3271 10.3767C23.3271 10.4819 23.2974 10.5139 23.1921 10.5116C22.5379 10.5116 21.8814 10.5116 21.2271 10.5116C20.9287 10.5184 20.6316 10.5528 20.3395 10.6146C20.0822 10.6619 19.8463 10.7891 19.6653 10.9779C19.4842 11.1668 19.3672 11.4078 19.3307 11.6669C19.2857 11.893 19.2612 12.1226 19.2575 12.3531C19.2575 13.1904 19.2575 14.0299 19.2575 14.8695C19.2575 14.8946 19.2575 14.9198 19.2575 14.9564H23.0229C23.1807 14.9564 23.183 14.9564 23.1624 15.1074C23.0778 15.7662 22.9885 16.425 22.9039 17.0816C22.8322 17.6321 22.7636 18.1827 22.698 18.7332C22.6729 18.9437 22.6797 18.9437 22.4693 18.9437H19.2644V28.8992C19.2644 28.9793 19.2644 29.0593 19.2644 29.1394L15.1147 29.1371Z" fill="white"></path>
|
||
<path id="Vector_2_Facebook" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1086">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Youtube</title>
|
||
<g id="YouTube" clip-path="url(#clip0_1717_1101)">
|
||
<path id="Vector_Youtube" d="M26.2571 11.4791C25.9025 11.1589 25.5709 10.9576 24.228 10.834C22.5512 10.6785 20.2797 10.6556 18.564 10.6533H16.4365C14.7208 10.6533 12.4493 10.6785 10.7725 10.834C9.43196 10.9576 9.09798 11.1589 8.7434 11.4791C7.81464 12.321 7.6202 14.6268 7.59961 16.8938C7.59961 17.3178 7.59961 17.741 7.59961 18.1635C7.62706 20.4121 7.82837 22.686 8.7434 23.521C9.09798 23.8412 9.42967 24.0425 10.7725 24.1661C12.4493 24.3216 14.7208 24.3445 16.4365 24.3468H18.564C20.2797 24.3468 22.5512 24.3216 24.228 24.1661C25.5686 24.0425 25.9025 23.8412 26.2571 23.521C27.1722 22.6929 27.3735 20.451 27.4009 18.2206C27.4009 17.7402 27.4009 17.2599 27.4009 16.7795C27.3735 14.5491 27.1699 12.3072 26.2571 11.4791ZM15.5604 20.5311V14.652L20.561 17.5001L15.5604 20.5311Z" fill="white"></path>
|
||
<path id="Vector_2_Youtube" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1101">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
</ul>
|
||
</div>
|
||
<div class="col-lg-3 col-12">
|
||
<p class="address_footer text-white">National Library of Medicine<br />
|
||
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
|
||
Bethesda, MD 20894</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
|
||
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
|
||
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
|
||
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
|
||
</div>
|
||
</div>
|
||
<div class="row">
|
||
<div class="col-lg-12 centered-lg">
|
||
<nav class="bottom-links">
|
||
<ul class="mt-3">
|
||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
</ul>
|
||
</nav>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
|
||
</div>
|
||
|
||
</div>
|
||
<div><input name="EntrezSystem2.PEntrez.DbConnector.Db" sid="1" type="hidden" value="medgen" /><input name="EntrezSystem2.PEntrez.DbConnector.LastDb" sid="1" type="hidden" value="medgen" /><input name="EntrezSystem2.PEntrez.DbConnector.Term" sid="1" type="hidden" value="C0025202[conceptid]" /><input name="EntrezSystem2.PEntrez.DbConnector.LastTabCmd" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastQueryKey" sid="1" type="hidden" value="43068" /><input name="EntrezSystem2.PEntrez.DbConnector.IdsFromResult" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastIdsFromResult" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkName" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkReadableName" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkSrcDb" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.Cmd" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.TabCmd" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.QueryKey" sid="1" type="hidden" /></div>
|
||
<input type="hidden" name="p$a" id="p$a" /><input type="hidden" name="p$l" id="p$l" value="EntrezSystem2" /><input type="hidden" name="p$st" id="p$st" value="medgen" /><input name="SessionId" id="SessionId" value="CE8B5AF87C7FFCB1_0191SID" disabled="disabled" type="hidden" /><input name="Snapshot" id="Snapshot" value="/projects/Phenotype/MedGen/MedGen@6.14" disabled="disabled" type="hidden" /></form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<!-- CE8B5AF87C7FFCB1_0191SID /projects/Phenotype/MedGen/MedGen@6.14 portal104 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
||
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
||
|
||
|
||
<script type='text/javascript' src='/portal/js/portal.js'></script><script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/js/4221766/3812534/4212053/3812535/3781605/4186313/2499590/3758627/4078478/3908752/3423/4018706/3891418/4212356/4078480/4078479/4025341/4076482/31971/35962/2733373/33966/3397055/4001808.js" snapshot="medgen"></script></body>
|
||
</html> |