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<meta name="keywords" content="C0021843, bowel obstruction, disease or syndrome, intestinal blockage, intestinal obstruction, intestinal obstructions, io - intestinal obstruction, obstruction of intestine, obstruction, intestinal, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Intestinal obstruction (Concept Id: C0021843)
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<!--
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||
UID=43933
|
||
ConceptID=C0021843
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Intestinal obstruction</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>43933</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0021843</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Intestinal Obstruction; Intestinal Obstructions; Obstruction, Intestinal</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Intestinal obstruction (81060008); Bowel obstruction (81060008); Obstruction of intestine (81060008); IO - Intestinal obstruction (81060008)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005214">HP:0005214</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0004565" target="_blank">MONDO:0004565</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0021843[DISCUI]&test_type=Clinical" ref="ncbi_uid=43933">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=43933" ref="ncbi_uid=43933">V</a></span></span><span class="TLline">Intestinal obstruction</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/272632" ref="tree=MeSH" title="MedGen record for Finding by Site or System">Finding by Site or System</a></span><ul><li><span class="TLline"><a href="/medgen/272669" ref="tree=MeSH" title="MedGen record for Digestive system finding">Digestive system finding</a></span><ul><li><span class="TLline"><a href="/medgen/437967" ref="tree=MeSH" title="MedGen record for Digestive System Obstruction">Digestive System Obstruction</a></span><ul><li><span class="matched_ds">Intestinal obstruction</span><ul><li><span class="TLline"><a href="/medgen/161" ref="tree=MeSH" title="MedGen record for Afferent loop syndrome">Afferent loop syndrome</a></span></li><li><span class="TLline"><a href="/medgen/4417" ref="tree=MeSH" title="MedGen record for Duodenal obstruction">Duodenal obstruction</a></span><ul><li><span class="TLline"><a href="/medgen/21404" ref="tree=MeSH" title="MedGen record for Superior mesenteric artery syndrome">Superior mesenteric artery syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/8800" ref="tree=MeSH" title="MedGen record for Fecal impaction">Fecal impaction</a></span></li><li><span class="TLline"><a href="/medgen/768596" ref="tree=MeSH" title="MedGen record for Functional intestinal obstruction">Functional intestinal obstruction</a></span></li><li><span class="TLline"><a href="/medgen/870770" ref="tree=MeSH" title="MedGen record for High intestinal obstruction">High intestinal obstruction</a></span></li><li><span class="TLline"><a href="/medgen/219874" ref="tree=MeSH" title="MedGen record for Ileus">Ileus</a></span><ul><li><span class="TLline"><a href="/medgen/5864" ref="tree=MeSH" title="MedGen record for Intestinal pseudo-obstruction">Intestinal pseudo-obstruction</a></span><ul><li><span class="TLline"><a href="/medgen/3167" ref="tree=MeSH" title="MedGen record for Colonic pseudo-obstruction">Colonic pseudo-obstruction</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/98322" ref="tree=MeSH" title="MedGen record for Mechanical ileus">Mechanical ileus</a></span><ul><li><span class="TLline"><a href="/medgen/473705" ref="tree=MeSH" title="MedGen record for Meconium ileus">Meconium ileus</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/18293" ref="tree=MeSH" title="MedGen record for Paralytic ileus">Paralytic ileus</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/256158" ref="tree=MeSH" title="MedGen record for Intestinal Stoma Obstruction">Intestinal Stoma Obstruction</a></span></li><li><span class="TLline"><a href="/medgen/43940" ref="tree=MeSH" title="MedGen record for Intussusception">Intussusception</a></span><ul><li><span class="TLline"><a href="/medgen/1779818" ref="tree=MeSH" title="MedGen record for Ileoileal intussusception">Ileoileal intussusception</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1646288" ref="tree=MeSH" title="MedGen record for Malignant Bowel Obstruction">Malignant Bowel Obstruction</a></span></li><li><span class="TLline"><a href="/medgen/1390517" ref="tree=MeSH" title="MedGen record for Neonatal intestinal obstruction">Neonatal intestinal obstruction</a></span></li><li><span class="TLline"><a href="/medgen/66721" ref="tree=MeSH" title="MedGen record for Obstruction of colon">Obstruction of colon</a></span></li><li><span class="TLline"><a href="/medgen/308441" ref="tree=MeSH" title="MedGen record for Rectal Obstruction">Rectal Obstruction</a></span></li><li><span class="TLline"><a href="/medgen/115984" ref="tree=MeSH" title="MedGen record for Small bowel obstruction">Small bowel obstruction</a></span><ul><li><span class="TLline"><a href="/medgen/305723" ref="tree=MeSH" title="MedGen record for Ileal Obstruction">Ileal Obstruction</a></span></li><li><span class="TLline"><a href="/medgen/1642729" ref="tree=MeSH" title="MedGen record for Jejunal Obstruction">Jejunal Obstruction</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/21892" ref="tree=MeSH" title="MedGen record for Volvulus">Volvulus</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_3532"><div><strong>Ulcerative colitis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>3532</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0009324</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/3532">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_19522"><div><strong>Protein-losing enteropathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>19522</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0033680</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) is characterized by abdominal pain and diarrhea, primary intestinal lymphangiectasia, hypoproteinemic edema, and malabsorption. Some patients also exhibit bowel inflammation, recurrent infections associated with hypogammaglobulinemia, and/or angiopathic thromboembolic disease. Patient T lymphocytes show increased complement activation, causing surface deposition of complement and generating soluble C5a (Ozen et al., 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/19522">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_116049"><div><strong>Gastrointestinal stroma tumor</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>116049</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0238198</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors found in the gastrointestinal tract that originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract. Approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum. GISTs are typically more cellular than other gastrointestinal sarcomas. They occur predominantly in patients who are 40 to 70 years old but in rare cases may occur in younger persons (Miettinen et al., 1999, 1999). GISTs are also seen as a feature in several syndromes, e.g., neurofibromatosis-1 (NF1; 162200) and GIST-plus syndrome (175510).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/116049">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331474"><div><strong>T-B+ severe combined immunodeficiency due to JAK3 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331474</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833275</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">JAK3-deficient severe combined immunodeficiency (SCID) is an inherited disorder of the immune system. Individuals with JAK3-deficient SCID lack the necessary immune cells to fight off certain bacteria, viruses, and fungi. They are prone to repeated and persistent infections that can be very serious or life-threatening. Often the organisms that cause infection in people with JAK3-deficient SCID are described as opportunistic because they ordinarily do not cause illness in healthy people. Affected infants typically develop chronic diarrhea, a fungal infection in the mouth called oral thrush, pneumonia, and skin rashes. Persistent illness also causes affected individuals to grow more slowly than other children. Without treatment, people with JAK3-deficient SCID usually live only into early childhood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331474">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_355730"><div><strong>Trichothiodystrophy 1, photosensitive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355730</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1866504</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Trichothiodystrophy is also associated with recurrent infections, particularly respiratory infections, which can be life-threatening. People with trichothiodystrophy may have abnormal red blood cells, including red blood cells that are smaller than normal. They may also have elevated levels of a type of hemoglobin called A2, which is a protein found in red blood cells. Other features of trichothiodystrophy can include dry, scaly skin (ichthyosis); abnormalities of the fingernails and toenails; clouding of the lens in both eyes from birth (congenital cataracts); poor coordination; and skeletal abnormalities including degeneration of both hips at an early age.\n\nAbout half of all people with trichothiodystrophy have a photosensitive form of the disorder, which causes them to be extremely sensitive to ultraviolet (UV) rays from sunlight. They develop a severe sunburn after spending just a few minutes in the sun. However, for reasons that are unclear, they do not develop other sun-related problems such as excessive freckling of the skin or an increased risk of skin cancer. Many people with trichothiodystrophy report that they do not sweat.\n\nIntellectual disability and delayed development are common in people with trichothiodystrophy, although most affected individuals are highly social with an outgoing and engaging personality. Some people with trichothiodystrophy have brain abnormalities that can be seen with imaging tests. A common neurological feature of this disorder is impaired myelin production (dysmyelination). Myelin is a fatty substance that insulates nerve cells and promotes the rapid transmission of nerve impulses.\n\nMothers of children with trichothiodystrophy may experience problems during pregnancy including pregnancy-induced high blood pressure (preeclampsia) and a related condition called HELLP syndrome that can damage the liver. Babies with trichothiodystrophy are at increased risk of premature birth, low birth weight, and slow growth. Most children with trichothiodystrophy have short stature compared to others their age. \n\nThe signs and symptoms of trichothiodystrophy vary widely. Mild cases may involve only the hair. More severe cases also cause delayed development, significant intellectual disability, and recurrent infections; severely affected individuals may survive only into infancy or early childhood.\n\nIn people with trichothiodystrophy, tests show that the hair is lacking sulfur-containing proteins that normally gives hair its strength. A cross section of a cut hair shows alternating light and dark banding that has been described as a "tiger tail."\n\nTrichothiodystrophy, commonly called TTD, is a rare inherited condition that affects many parts of the body. The hallmark of this condition is hair that is sparse and easily broken. </div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/355730">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1783630"><div><strong>Visceral myopathy 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1783630</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543466</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Visceral myopathy-2 (VSCM2) is characterized by gastrointestinal symptoms resulting from intestinal dysmotility and paresis, including abdominal distention, pain, nausea, and vomiting. Some patients exhibit predominantly esophageal symptoms, with hiatal hernia and severe reflux resulting in esophagitis and stricture, whereas others experience chronic intestinal pseudoobstruction. Bladder involvement resulting in megacystis and megaureter has also been observed and may be evident at birth (Dong et al., 2019; Gilbert et al. (2020)).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1783630">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1806192"><div><strong>Gastrointestinal defects and immunodeficiency syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1806192</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5680044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Gastrointestinal defects and immunodeficiency syndrome-1 (GIDID1) is characterized by multiple intestinal atresia, in which atresia occurs at various levels throughout the small and large intestines. Surgical outcomes are poor, and the condition is usually fatal within the first month of life. Some patients exhibit inflammatory bowel disease (IBD), with or without intestinal atresia, and in some cases, the intestinal features are associated with either mild or severe combined immunodeficiency (Samuels et al., 2013; Avitzur et al., 2014; Lemoine et al., 2014). Genetic Heterogeneity of GIDID See also GIDID2 (619708), caused by mutation in the PI4KA gene (600286) on chromosome 22q11.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1806192">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1857168"><div><strong>Cutis laxa, autosomal recessive, type 1d</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1857168</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935602</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal recessive cutis laxa type ID (ARCL1D) is characterized by facial dysmorphism, joint hypermobility, muscle hypotonia, and multiple severe herniations, including inguinal, ventral, diaphragmatic, sciatic, and obturator, as well as large diverticula of the gastrointestinal tract and urinary bladder. The skin is thin and translucent with easy bruising; the degree of laxity is variable and progresses with age in some patients (Megarbane et al., 2012; Bizzari et al., 2020; Driver et al., 2020; Verlee et al., 2021). For a general phenotypic description and discussion of genetic heterogeneity of autosomal recessive cutis laxa, see ARCL1A (219100).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1857168">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1857168" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cutis laxa, autosomal recessive, type 1d</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1806192" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastrointestinal defects and immunodeficiency syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_116049" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastrointestinal stroma tumor</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_19522" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Protein-losing enteropathy</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331474" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">T-B+ severe combined immunodeficiency due to JAK3 deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355730" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Trichothiodystrophy 1, photosensitive</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_3532" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ulcerative colitis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1783630" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Visceral myopathy 2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37054692">Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yamamoto H,
|
||
Sakamoto H,
|
||
Kumagai H,
|
||
Abe T,
|
||
Ishiguro S,
|
||
Uchida K,
|
||
Kawasaki Y,
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||
Saida Y,
|
||
Sano Y,
|
||
Takeuchi Y,
|
||
Tajika M,
|
||
Nakajima T,
|
||
Banno K,
|
||
Funasaka Y,
|
||
Hori S,
|
||
Yamaguchi T,
|
||
Yoshida T,
|
||
Ishikawa H,
|
||
Iwama T,
|
||
Okazaki Y,
|
||
Saito Y,
|
||
Matsuura N,
|
||
Mutoh M,
|
||
Tomita N,
|
||
Akiyama T,
|
||
Yamamoto T,
|
||
Ishida H,
|
||
Nakayama Y</span><br />
|
||
<span class="medgenPMjournal">Digestion</span>
|
||
2023;104(5):335-347.
|
||
Epub 2023 Apr 13
|
||
doi: 10.1159/000529799.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37054692" target="_blank">37054692</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30215917">Intestinal Obstruction: Evaluation and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jackson P,
|
||
Vigiola Cruz M</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2018 Sep 15;98(6):362-367.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30215917" target="_blank">30215917</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21243991">Evaluation and management of intestinal obstruction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jackson PG,
|
||
Raiji MT</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2011 Jan 15;83(2):159-65.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21243991" target="_blank">21243991</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22intestinal%20obstruction%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (404)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38677830">Surgical Emergencies in Inflammatory Bowel Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Van Eaton J,
|
||
Hatch QM</span><br />
|
||
<span class="medgenPMjournal">Surg Clin North Am</span>
|
||
2024 Jun;104(3):685-699.
|
||
Epub 2023 Dec 14
|
||
doi: 10.1016/j.suc.2023.11.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38677830" target="_blank">38677830</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30215917">Intestinal Obstruction: Evaluation and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jackson P,
|
||
Vigiola Cruz M</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2018 Sep 15;98(6):362-367.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30215917" target="_blank">30215917</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27916022">A wandering tube.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dubin I,
|
||
Gelber M,
|
||
Schattner A</span><br />
|
||
<span class="medgenPMjournal">CJEM</span>
|
||
2017 Sep;19(5):398-399.
|
||
Epub 2016 Dec 5
|
||
doi: 10.1017/cem.2016.393.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27916022" target="_blank">27916022</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21243992">Intestinal obstruction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Am Fam Physician</span>
|
||
2011 Jan 15;83(2):166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21243992" target="_blank">21243992</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21243991">Evaluation and management of intestinal obstruction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jackson PG,
|
||
Raiji MT</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2011 Jan 15;83(2):159-65.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21243991" target="_blank">21243991</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Intestinal%20obstruction%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6612)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30243455">Small Bowel Obstruction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bower KL,
|
||
Lollar DI,
|
||
Williams SL,
|
||
Adkins FC,
|
||
Luyimbazi DT,
|
||
Bower CE</span><br />
|
||
<span class="medgenPMjournal">Surg Clin North Am</span>
|
||
2018 Oct;98(5):945-971.
|
||
Epub 2018 Aug 7
|
||
doi: 10.1016/j.suc.2018.05.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30243455" target="_blank">30243455</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22194504">Neonatal intestinal obstruction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vinocur DN,
|
||
Lee EY,
|
||
Eisenberg RL</span><br />
|
||
<span class="medgenPMjournal">AJR Am J Roentgenol</span>
|
||
2012 Jan;198(1):W1-10.
|
||
doi: 10.2214/AJR.11.6931.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22194504" target="_blank">22194504</a></div>
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<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/35274188">MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Madariaga A,
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Lau J,
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Ghoshal A,
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Dzierżanowski T,
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Larkin P,
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Sobocki J,
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Dickman A,
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Furness K,
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Fazelzad R,
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Crawford GB,
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<span class="bold">PMID: </span><a href="/pubmed/35274188" target="_blank">35274188</a><a href="/pmc/articles/PMC9046338" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/34936379">Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Baxter NN,
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Kennedy EB,
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Bergsland E,
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Berlin J,
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George TJ,
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Gill S,
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Gold PJ,
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Hantel A,
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Jones L,
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Lieu C,
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Mahmoud N,
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2022 Mar 10;40(8):892-910.
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Epub 2021 Dec 22
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<span class="bold">PMID: </span><a href="/pubmed/34936379" target="_blank">34936379</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32683979">Post-cholecystectomy Gallstone Ileus.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Meier J,
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<div class="nl"><a target="_blank" href="/pubmed/28439845">A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rami Reddy SR,
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<span class="medgenPMjournal">Curr Gastroenterol Rep</span>
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<span class="bold">PMID: </span><a href="/pubmed/28439845" target="_blank">28439845</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/24092941">Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">ten Broek RP,
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Issa Y,
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van Santbrink EJ,
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Bouvy ND,
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Kruitwagen RF,
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Jeekel J,
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<span class="bold">PMID: </span><a href="/pubmed/24092941" target="_blank">24092941</a><a href="/pmc/articles/PMC3789584" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Intestinal%20obstruction%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (261)</a></div></div>
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0021843%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (7)</a></li>
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<li><a href="/gtr/tests?term=C0021843%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (7)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0021843%5bDISCUI%5d" target="_blank">See all (7)</a></total></li>
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