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<meta name="keywords" content="C0014761, alloimmune hemolytic disease of newborn, disease or syndrome, ef - erythroblastosis fetalis, ef - erythroblastosis foetalis, erythroblastoses, fetal, erythroblastosis fetali, erythroblastosis fetalis, erythroblastosis, fetal, fetal erythroblastoses, fetal erythroblastosis, fetali, erythroblastosis, fetalis, erythroblastosis, haemolytic disease due to rhesus isoimmunisation, hdfn, hdn - hemolytic disease of the newborn, hemolytic disease of fetus or newborn, hemolytic disease of fetus or newborn due to isoimmunization, hemolytic disease of newborn, hemolytic disease of the fetus or newborn, hemolytic disease of the foetus or newborn, hemolytic disease of the newborn, isoimmune hemolytic disease of the newborn, isoimmunization of newborn, newborn hemolytic disease, newborn hemolytic diseases, rhesus isoimmunisation of the newborn, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A disorder of the fetus or newborn that occurs when fetal cells that are coated with IgG alloantibodies from the mother attack antigens inherited from the father. Severity can range from absence of symptoms to death." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Hemolytic disease of fetus OR newborn due to isoimmunization (Concept Id: C0014761)
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<!--
UID=4530
ConceptID=C0014761
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hemolytic disease of fetus OR newborn due to isoimmunization</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>4530</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0014761</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Fetal erythroblastosis; Hemolytic Disease of the Newborn</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Hemolytic disease of fetus OR newborn due to isoimmunization (387705004); EF - Erythroblastosis fetalis (387705004); Erythroblastosis fetalis (387705004); Alloimmune hemolytic disease of newborn (387705004); Isoimmunization of newborn (387705004); HDN - Hemolytic disease of the newborn (387705004); Hemolytic disease of the newborn (387705004); Hemolytic disease of fetus OR newborn (387705004)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0006760" target="_blank">MONDO:0006760</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A disorder of the fetus or newborn that occurs when fetal cells that are coated with IgG alloantibodies from the mother attack antigens inherited from the father. Severity can range from absence of symptoms to death. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C5194182[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=1673948">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C5194182[DISCUI]&amp;test_type=Research&amp;redirect=true" ref="ncbi_uid=1673948">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=1673948" ref="ncbi_uid=1673948">V</a></span></span><span class="TLline"><a href="/medgen/1673948" ref="tree=GTR&amp;ncbi_uid=1673948&amp;link_uid=1673948" title="View MedGen record for 'Microcytic anemia'">Microcytic anemia</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0014761[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=4530">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=4530" ref="ncbi_uid=4530">V</a></span></span><span class="TLline">Hemolytic disease of fetus OR newborn due to isoimmunization</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0271901[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=124413">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/124413" ref="tree=GTR&amp;ncbi_uid=124413&amp;link_uid=124413" title="View MedGen record for 'Hypochromic microcytic anemia'">Hypochromic microcytic anemia</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2673913[DISCUI]&amp;test_type=Clinical&amp;redirect=true" ref="ncbi_uid=388759">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=388759" target="_blank" href="/omim/600523">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/388759" ref="tree=GTR&amp;ncbi_uid=388759&amp;link_uid=388759" title="View MedGen record for 'Anemia, hypochromic microcytic with iron overload'">Anemia, hypochromic microcytic with iron overload</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3806153[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=812483">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C3806153[DISCUI]&amp;test_type=Research&amp;redirect=true" ref="ncbi_uid=812483">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=812483" target="_blank" href="/omim/206100">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=812483" ref="ncbi_uid=812483">V</a></span></span><span class="TLline"><a href="/medgen/812483" ref="tree=GTR&amp;ncbi_uid=812483&amp;link_uid=812483" title="View MedGen record for 'Microcytic anemia with liver iron overload'">Microcytic anemia with liver iron overload</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3808920[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=815250">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=815250" target="_blank" href="/omim/609671">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=815250" ref="ncbi_uid=815250">V</a></span></span><span class="TLline"><a href="/medgen/815250" ref="tree=GTR&amp;ncbi_uid=815250&amp;link_uid=815250" title="View MedGen record for 'Severe congenital hypochromic anemia with ringed sideroblasts'">Severe congenital hypochromic anemia with ringed sideroblasts</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0162316[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=57668">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=57668" ref="ncbi_uid=57668">V</a></span></span><span class="TLline"><a href="/medgen/57668" ref="tree=GTR&amp;ncbi_uid=57668&amp;link_uid=57668" title="View MedGen record for 'Iron deficiency anemia'">Iron deficiency anemia</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0085576[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=39081">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=39081" target="_blank" href="/omim/206200">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=39081" ref="ncbi_uid=39081">V</a></span></span><span class="TLline"><a href="/medgen/39081" ref="tree=GTR&amp;ncbi_uid=39081&amp;link_uid=39081" title="View MedGen record for 'Iron-refractory iron deficiency anemia'">Iron-refractory iron deficiency anemia</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/14319" ref="tree=MeSH" title="MedGen record for Congenital, Hereditary, and Neonatal Diseases and Abnormalities">Congenital, Hereditary, and Neonatal Diseases and Abnormalities</a></span><ul><li><span class="TLline"><a href="/medgen/8822" ref="tree=MeSH" title="MedGen record for Fetal disorder">Fetal disorder</a></span><ul><li><span class="matched_ds">Hemolytic disease of fetus OR newborn due to isoimmunization</span><ul><li><span class="TLline"><a href="/medgen/859621" ref="tree=MeSH" title="MedGen record for Anti-D Hemolytic Disease of the Newborn">Anti-D Hemolytic Disease of the Newborn</a></span></li><li><span class="TLline"><a href="/medgen/44018" ref="tree=MeSH" title="MedGen record for Bilirubin encephalopathy">Bilirubin encephalopathy</a></span><ul><li><span class="TLline"><a href="/medgen/1808922" ref="tree=MeSH" title="MedGen record for Acute bilirubin encephalopathy">Acute bilirubin encephalopathy</a></span></li><li><span class="TLline"><a href="/medgen/1806573" ref="tree=MeSH" title="MedGen record for Chronic bilirubin encephalopathy">Chronic bilirubin encephalopathy</a></span></li><li><span class="TLline"><a href="/medgen/542597" ref="tree=MeSH" title="MedGen record for Kernicterus due to isoimmunization">Kernicterus due to isoimmunization</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/542596" ref="tree=MeSH" title="MedGen record for Hemolytic disease of fetus OR newborn due to ABO immunization">Hemolytic disease of fetus OR newborn due to ABO immunization</a></span></li><li><span class="TLline"><a href="/medgen/6947" ref="tree=MeSH" title="MedGen record for Hydrops fetalis">Hydrops fetalis</a></span><ul><li><span class="TLline"><a href="/medgen/105328" ref="tree=MeSH" title="MedGen record for Immune hydrops fetalis">Immune hydrops fetalis</a></span></li><li><span class="TLline"><a href="/medgen/105327" ref="tree=MeSH" title="MedGen record for Non-immune hydrops fetalis">Non-immune hydrops fetalis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/810688" ref="tree=MeSH" title="MedGen record for Rhesus Hemolytic Disease of the Newborn">Rhesus Hemolytic Disease of the Newborn</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/30718211">Fetal anemia: Diagnosis and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prefumo F,
Fichera A,
Fratelli N,
Sartori E</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
2019 Jul;58:2-14.
Epub 2019 Jan 9
doi: 10.1016/j.bpobgyn.2019.01.001.
<span class="bold">PMID: </span><a href="/pubmed/30718211" target="_blank">30718211</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29470342">ACOG Practice Bulletin No. 192: Management of Alloimmunization During Pregnancy.</a></div>
<div class="portlet_content ln"><span class="medgenPMjournal">Obstet Gynecol</span>
2018 Mar;131(3):e82-e90.
doi: 10.1097/AOG.0000000000002528.
<span class="bold">PMID: </span><a href="/pubmed/29470342" target="_blank">29470342</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28742673">Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.</a></div>
<div class="portlet_content ln"><span class="medgenPMjournal">Obstet Gynecol</span>
2017 Aug;130(2):e57-e70.
doi: 10.1097/AOG.0000000000002232.
<span class="bold">PMID: </span><a href="/pubmed/28742673" target="_blank">28742673</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hemolytic%20disease%20of%20fetus%20or%20newborn%20due%20to%20isoimmunization)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (193)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36611144">Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Winter DP,
Kaminski A,
Tjoa ML,
Oepkes D</span><br />
<span class="medgenPMjournal">BMC Pregnancy Childbirth</span>
2023 Jan 7;23(1):12.
doi: 10.1186/s12884-022-05329-z.
<span class="bold">PMID: </span><a href="/pubmed/36611144" target="_blank">36611144</a><a href="/pmc/articles/PMC9824959" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36469119">History and current standard of postnatal management in hemolytic disease of the fetus and newborn.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">De Winter DP,
Hulzebos C,
Van 't Oever RM,
De Haas M,
Verweij EJ,
Lopriore E</span><br />
<span class="medgenPMjournal">Eur J Pediatr</span>
2023 Feb;182(2):489-500.
Epub 2022 Dec 5
doi: 10.1007/s00431-022-04724-0.
<span class="bold">PMID: </span><a href="/pubmed/36469119" target="_blank">36469119</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34936250">Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Páez M,
Jiménez M,
Corredor A</span><br />
<span class="medgenPMjournal">Biomedica</span>
2021 Dec 15;41(4):643-650.
doi: 10.7705/biomedica.5930.
<span class="bold">PMID: </span><a href="/pubmed/34936250" target="_blank">34936250</a><a href="/pmc/articles/PMC8740393" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32687543">Hemolytic disease of the fetus and newborn due to Rh(D) incompatibility: A preventable disease that still produces significant morbidity and mortality in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pegoraro V,
Urbinati D,
Visser GHA,
Di Renzo GC,
Zipursky A,
Stotler BA,
Spitalnik SL</span><br />
<span class="medgenPMjournal">PLoS One</span>
2020;15(7):e0235807.
Epub 2020 Jul 20
doi: 10.1371/journal.pone.0235807.
<span class="bold">PMID: </span><a href="/pubmed/32687543" target="_blank">32687543</a><a href="/pmc/articles/PMC7371205" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28419427">How I manage children with neutropenia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dale DC</span><br />
<span class="medgenPMjournal">Br J Haematol</span>
2017 Aug;178(3):351-363.
Epub 2017 Apr 17
doi: 10.1111/bjh.14677.
<span class="bold">PMID: </span><a href="/pubmed/28419427" target="_blank">28419427</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic%20disease%20of%20fetus%20OR%20newborn%20due%20to%20isoimmunization%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1347)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37385374">Mirror syndrome: a systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Biswas S,
Gomez J,
Horgan R,
Sibai BM,
Saad A,
Powel JE,
Al-Kouatly HB</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol MFM</span>
2023 Sep;5(9):101067.
Epub 2023 Jun 28
doi: 10.1016/j.ajogmf.2023.101067.
<span class="bold">PMID: </span><a href="/pubmed/37385374" target="_blank">37385374</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36469119">History and current standard of postnatal management in hemolytic disease of the fetus and newborn.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">De Winter DP,
Hulzebos C,
Van 't Oever RM,
De Haas M,
Verweij EJ,
Lopriore E</span><br />
<span class="medgenPMjournal">Eur J Pediatr</span>
2023 Feb;182(2):489-500.
Epub 2022 Dec 5
doi: 10.1007/s00431-022-04724-0.
<span class="bold">PMID: </span><a href="/pubmed/36469119" target="_blank">36469119</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33494881">Hemolytic Disease of the Fetus and Newborn: Historical and Current State.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jackson ME,
Baker JM</span><br />
<span class="medgenPMjournal">Clin Lab Med</span>
2021 Mar;41(1):133-151.
Epub 2020 Dec 24
doi: 10.1016/j.cll.2020.10.009.
<span class="bold">PMID: </span><a href="/pubmed/33494881" target="_blank">33494881</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30718211">Fetal anemia: Diagnosis and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prefumo F,
Fichera A,
Fratelli N,
Sartori E</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
2019 Jul;58:2-14.
Epub 2019 Jan 9
doi: 10.1016/j.bpobgyn.2019.01.001.
<span class="bold">PMID: </span><a href="/pubmed/30718211" target="_blank">30718211</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28419427">How I manage children with neutropenia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dale DC</span><br />
<span class="medgenPMjournal">Br J Haematol</span>
2017 Aug;178(3):351-363.
Epub 2017 Apr 17
doi: 10.1111/bjh.14677.
<span class="bold">PMID: </span><a href="/pubmed/28419427" target="_blank">28419427</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic%20disease%20of%20fetus%20OR%20newborn%20due%20to%20isoimmunization%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (685)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/39115062">Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Moise KJ Jr,
Ling LE,
Oepkes D,
Tiblad E,
Verweij EJTJ,
Lopriore E,
Smoleniec J,
Sachs UJ,
Bein G,
Kilby MD,
Miller RS,
Devlieger R,
Audibert F,
Emery SP,
Markham K,
Norton ME,
Ocón-Hernández O,
Pandya P,
Pereira L,
Silver RM,
Windrim R,
Streisand JB,
Leu JH,
Mirza A,
Smith V,
Schwartz LB,
Tjoa ML,
Saeed-Khawaja S,
Komatsu Y,
Bussel JB;
UNITY Study Group</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2024 Aug 8;391(6):526-537.
doi: 10.1056/NEJMoa2314466.
<span class="bold">PMID: </span><a href="/pubmed/39115062" target="_blank">39115062</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30808636">Transfusion-related red blood cell alloantibodies: induction and consequences.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tormey CA,
Hendrickson JE</span><br />
<span class="medgenPMjournal">Blood</span>
2019 Apr 25;133(17):1821-1830.
Epub 2019 Feb 26
doi: 10.1182/blood-2018-08-833962.
<span class="bold">PMID: </span><a href="/pubmed/30808636" target="_blank">30808636</a><a href="/pmc/articles/PMC6484385" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30718211">Fetal anemia: Diagnosis and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prefumo F,
Fichera A,
Fratelli N,
Sartori E</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
2019 Jul;58:2-14.
Epub 2019 Jan 9
doi: 10.1016/j.bpobgyn.2019.01.001.
<span class="bold">PMID: </span><a href="/pubmed/30718211" target="_blank">30718211</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28742673">Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.</a></div>
<div class="portlet_content ln"><span class="medgenPMjournal">Obstet Gynecol</span>
2017 Aug;130(2):e57-e70.
doi: 10.1097/AOG.0000000000002232.
<span class="bold">PMID: </span><a href="/pubmed/28742673" target="_blank">28742673</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28419427">How I manage children with neutropenia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dale DC</span><br />
<span class="medgenPMjournal">Br J Haematol</span>
2017 Aug;178(3):351-363.
Epub 2017 Apr 17
doi: 10.1111/bjh.14677.
<span class="bold">PMID: </span><a href="/pubmed/28419427" target="_blank">28419427</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic%20disease%20of%20fetus%20OR%20newborn%20due%20to%20isoimmunization%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (500)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/19335378">Fatal hemolytic disease of the fetus and newborn possibly due to anti-Jr.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Arriaga F,
Gomez I,
Linares MD,
Gascon A,
Carpio N,
Perales A</span><br />
<span class="medgenPMjournal">Transfusion</span>
2009 Apr;49(4):813.
doi: 10.1111/j.1537-2995.2008.02087.x.
<span class="bold">PMID: </span><a href="/pubmed/19335378" target="_blank">19335378</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15930239">Vigintiphobia revisited.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Watchko JF</span><br />
<span class="medgenPMjournal">Pediatrics</span>
2005 Jun;115(6):1747-53.
doi: 10.1542/peds.2004-1748.
<span class="bold">PMID: </span><a href="/pubmed/15930239" target="_blank">15930239</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10620643">Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mari G,
Deter RL,
Carpenter RL,
Rahman F,
Zimmerman R,
Moise KJ Jr,
Dorman KF,
Ludomirsky A,
Gonzalez R,
Gomez R,
Oz U,
Detti L,
Copel JA,
Bahado-Singh R,
Berry S,
Martinez-Poyer J,
Blackwell SC</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2000 Jan 6;342(1):9-14.
doi: 10.1056/NEJM200001063420102.
<span class="bold">PMID: </span><a href="/pubmed/10620643" target="_blank">10620643</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8542030">Rh haemolytic disease of the newborn and Rh genotyping by RFLP--and allele-specific--PCR.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Le Van Kim C,
Colin Y,
Brossard Y,
Cartron JP</span><br />
<span class="medgenPMjournal">Transfus Clin Biol</span>
1995;2(4):317-24.
doi: 10.1016/s1246-7820(05)80098-9.
<span class="bold">PMID: </span><a href="/pubmed/8542030" target="_blank">8542030</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1536591">Rhesus haemolytic disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Whittle MJ</span><br />
<span class="medgenPMjournal">Arch Dis Child</span>
1992 Jan;67(1 Spec No):65-8.
doi: 10.1136/adc.67.1_spec_no.65.
<span class="bold">PMID: </span><a href="/pubmed/1536591" target="_blank">1536591</a><a href="/pmc/articles/PMC1590321" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic%20disease%20of%20fetus%20OR%20newborn%20due%20to%20isoimmunization%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (471)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/37853331">Hemolytic disease of the fetus and newborn: rapid review of postnatal care and outcomes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Winter DP,
Kaminski A,
Tjoa ML,
Oepkes D,
Lopriore E</span><br />
<span class="medgenPMjournal">BMC Pregnancy Childbirth</span>
2023 Oct 18;23(1):738.
doi: 10.1186/s12884-023-06061-y.
<span class="bold">PMID: </span><a href="/pubmed/37853331" target="_blank">37853331</a><a href="/pmc/articles/PMC10583489" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36611144">Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Winter DP,
Kaminski A,
Tjoa ML,
Oepkes D</span><br />
<span class="medgenPMjournal">BMC Pregnancy Childbirth</span>
2023 Jan 7;23(1):12.
doi: 10.1186/s12884-022-05329-z.
<span class="bold">PMID: </span><a href="/pubmed/36611144" target="_blank">36611144</a><a href="/pmc/articles/PMC9824959" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34936250">Hemolytic disease in fetuses and newborns due to antibodies against the M-antigen.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Páez M,
Jiménez M,
Corredor A</span><br />
<span class="medgenPMjournal">Biomedica</span>
2021 Dec 15;41(4):643-650.
doi: 10.7705/biomedica.5930.
<span class="bold">PMID: </span><a href="/pubmed/34936250" target="_blank">34936250</a><a href="/pmc/articles/PMC8740393" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28419427">How I manage children with neutropenia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dale DC</span><br />
<span class="medgenPMjournal">Br J Haematol</span>
2017 Aug;178(3):351-363.
Epub 2017 Apr 17
doi: 10.1111/bjh.14677.
<span class="bold">PMID: </span><a href="/pubmed/28419427" target="_blank">28419427</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20507641">Alpha-thalassaemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Harteveld CL,
Higgs DR</span><br />
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
2010 May 28;5:13.
doi: 10.1186/1750-1172-5-13.
<span class="bold">PMID: </span><a href="/pubmed/20507641" target="_blank">20507641</a><a href="/pmc/articles/PMC2887799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic%20disease%20of%20fetus%20OR%20newborn%20due%20to%20isoimmunization%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (454)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/38588966">Intravenous immunoglobulin for the treatment of severe maternal alloimmunization: individual patient data meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mustafa HJ,
Sambatur EV,
Pagani G,
D'Antonio F,
Maisonneuve E,
Maurice P,
Zwiers C,
Verweij JEJT,
Flood A,
Shamshirsaz AA,
Jouannic JM,
Khalil A</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
2024 Oct;231(4):417-429.e21.
Epub 2024 Apr 7
doi: 10.1016/j.ajog.2024.03.044.
<span class="bold">PMID: </span><a href="/pubmed/38588966" target="_blank">38588966</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37900088">Misclassification of RhD variants among pregnant women: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Owaidah AY,
Yamani LZ</span><br />
<span class="medgenPMjournal">J Med Life</span>
2023 Jul;16(7):981-989.
doi: 10.25122/jml-2023-0004.
<span class="bold">PMID: </span><a href="/pubmed/37900088" target="_blank">37900088</a><a href="/pmc/articles/PMC10600664" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37385374">Mirror syndrome: a systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Biswas S,
Gomez J,
Horgan R,
Sibai BM,
Saad A,
Powel JE,
Al-Kouatly HB</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol MFM</span>
2023 Sep;5(9):101067.
Epub 2023 Jun 28
doi: 10.1016/j.ajogmf.2023.101067.
<span class="bold">PMID: </span><a href="/pubmed/37385374" target="_blank">37385374</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36611144">Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Winter DP,
Kaminski A,
Tjoa ML,
Oepkes D</span><br />
<span class="medgenPMjournal">BMC Pregnancy Childbirth</span>
2023 Jan 7;23(1):12.
doi: 10.1186/s12884-022-05329-z.
<span class="bold">PMID: </span><a href="/pubmed/36611144" target="_blank">36611144</a><a href="/pmc/articles/PMC9824959" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24514437">Intravenous immunoglobulin in isoimmune haemolytic disease of newborn: an updated systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Louis D,
More K,
Oberoi S,
Shah PS</span><br />
<span class="medgenPMjournal">Arch Dis Child Fetal Neonatal Ed</span>
2014 Jul;99(4):F325-31.
Epub 2014 Feb 10
doi: 10.1136/archdischild-2013-304878.
<span class="bold">PMID: </span><a href="/pubmed/24514437" target="_blank">24514437</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic%20disease%20of%20fetus%20OR%20newborn%20due%20to%20isoimmunization%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div></div>
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