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<!--
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UID=892977
|
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ConceptID=C4072889
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased circulating follicle stimulating hormone concentration</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>892977</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4072889</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Decreased circulating follicle stimulating hormone level</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030341">HP:0030341</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">A reduction of the circulating level of follicle-stimulating hormone (FSH). [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased circulating follicle stimulating hormone concentration</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/893021" ref="tree=MeSH" title="MedGen record for Abnormality of the endocrine system">Abnormality of the endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/871176" ref="tree=MeSH" title="MedGen record for Abnormal circulating hormone concentration">Abnormal circulating hormone concentration</a></span><ul><li><span class="TLline"><a href="/medgen/892748" ref="tree=MeSH" title="MedGen record for Abnormal circulating gonadotropin concentration">Abnormal circulating gonadotropin concentration</a></span><ul><li><span class="TLline"><a href="/medgen/892827" ref="tree=MeSH" title="MedGen record for Abnormal circulating follicle-stimulating hormone concentration">Abnormal circulating follicle-stimulating hormone concentration</a></span><ul><li><span class="matched_ds">Decreased circulating follicle stimulating hormone concentration</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_209236"><div><strong>Pituitary hormone deficiency, combined, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>209236</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0878683</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PROP1-related combined pituitary hormone deficiency (CPHD) is associated with deficiencies of: growth hormone (GH); thyroid-stimulating hormone (TSH); the two gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH); prolactin (PrL); and occasionally adrenocorticotropic hormone (ACTH). At birth, in contrast to individuals with congenital CPHD of other etiologies, neonates with PROP1-related CPHD lack perinatal signs of hypopituitarism. Mean birth weights and lengths are usually within the normal range and neonatal hypoglycemia and prolonged neonatal jaundice are not prevalent findings. Most affected individuals are ascertained because of short stature during childhood. Although TSH deficiency can present shortly after birth, TSH deficiency usually occurs with or after the onset of GH deficiency. Hypothyroidism is usually mild. FSH and LH deficiencies are typically identified at the age of onset of puberty. Affected individuals can have absent or delayed and incomplete secondary sexual development with infertility. Untreated males usually have a small penis and small testes. Some females experience menarche but subsequently require hormone replacement therapy. ACTH deficiency is less common and, when present, usually occurs in adolescence or adulthood. Neuroimaging of hypothalamic-pituitary region usually demonstrates a hypoplastic or normal anterior pituitary lobe and a normal posterior pituitary lobe.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/209236">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_295872"><div><strong>Hypogonadotropic hypogonadism 1 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>295872</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1563719</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/295872">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_333437"><div><strong>Kallmann syndrome with spastic paraplegia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333437</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839911</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/333437">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347798"><div><strong>Ataxia-hypogonadism-choroidal dystrophy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347798</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1859093</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PNPLA6 disorders span a phenotypic continuum characterized by variable combinations of cerebellar ataxia; upper motor neuron involvement manifesting as spasticity and/or brisk reflexes; chorioretinal dystrophy associated with variable degrees of reduced visual function; and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics). The hypogonadotropic hypogonadism occurs either in isolation or as part of anterior hypopituitarism (growth hormone, thyroid hormone, or gonadotropin deficiencies). Common but less frequent features are peripheral neuropathy (usually of axonal type manifesting as reduced distal reflexes, diminished vibratory sensation, and/or distal muscle wasting); hair anomalies (long eyelashes, bushy eyebrows, or scalp alopecia); short stature; and impaired cognitive functioning (learning disabilities in children; deficits in attention, visuospatial abilities, and recall in adults). Some of these features can occur in distinct clusters on the phenotypic continuum: Boucher-Neuhäuser syndrome (cerebellar ataxia, chorioretinal dystrophy, and hypogonadotropic hypogonadism); Gordon Holmes syndrome (cerebellar ataxia, hypogonadotropic hypogonadism, and – to a variable degree – brisk reflexes); Oliver-McFarlane syndrome (trichomegaly, chorioretinal dystrophy, short stature, intellectual disability, and hypopituitarism); Laurence-Moon syndrome; and spastic paraplegia type 39 (SPG39) (upper motor neuron involvement, peripheral neuropathy, and sometimes reduced cognitive functioning and/or cerebellar ataxia).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347798">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1789612"><div><strong>Delayed puberty, self-limited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1789612</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2874202</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Self-limited delayed puberty (DPSL) is characterized by delayed development of Tanner stage G2 accompanied by low serum gonadotropins. Affected individuals experience spontaneous attainment of Tanner stage G4 by 18 years of age, with normalization of gonadotropins, which excludes a diagnosis of hypogonadotropic hypogonadism (see 147950) (Mancini et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1789612">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462790"><div><strong>Pituitary hormone deficiency, combined, 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462790</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151440</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any combined pituitary hormone deficiencies, genetic form in which the cause of the disease is a mutation in the OTX2 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462790">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_762090"><div><strong>Hypogonadotropic hypogonadism 13 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>762090</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3541462</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/762090">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766755"><div><strong>Hypogonadotropic hypogonadism 8 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766755</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553841</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766755">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766757"><div><strong>Hypogonadotropic hypogonadism 10 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766757</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553843</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766757">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766935"><div><strong>Hypogonadotropic hypogonadism 16 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766935</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554021</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766935">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863425"><div><strong>Hypogonadotropic hypogonadism 22 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863425</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014988</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863425">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1785671"><div><strong>BDV syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1785671</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543403</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">BDV syndrome (BDVS) is an autosomal recessive disorder characterized by early-onset profound obesity, hyperphagia, and moderately impaired intellectual development accompanied by infantile hypotonia and other endocrine disorders including hypogonadotropic hypogonadism, hypothyroidism, and insulin resistance (summary by Bosch et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1785671">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1806136"><div><strong>Hypogonadotropic hypogonadism 24 without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1806136</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5574957</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).' For a general phenotypic description and a discussion of genetic heterogeneity of hypogonadotropic hypogonadism with or without anosmia, see 147950.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1806136">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1810165"><div><strong>Hypogonadotropic hypogonadism 27 without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1810165</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676921</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypogonadotropic hypogonadism-27 without anosmia (HH27) is characterized by lack of pubertal development associated with onset of obesity in early adolescence (Topaloglu et al., 2022). Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).'</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1810165">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1808634"><div><strong>Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1808634</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676924</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism (CDIDHH) is characterized by delayed motor development, ataxia, severe progressive scoliosis, moderate to severe intellectual disability, and delayed sexual development. Cerebellar hypoplasia has been observed in some patients (Whittaker et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1808634">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1841011"><div><strong>Pituitary hormone deficiency, combined or isolated, 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841011</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830375</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Combined pituitary hormone deficiency-8 (CPHD8) is an autosomal dominant disorder characterized by deficiency of one or more of the pituitary hormones. Affected individuals have short stature due to growth hormone (GH; 139250) deficiency with variable deficiencies of other pituitary hormones, including TSH (see 188540), ACTH, and LH/FSH (see 118850). Posterior pituitary deficiency leading to central diabetes insipidus is rare (Bashamboo et al., 2017). Many patients are diagnosed with 'pituitary stalk interruption syndrome' (PSIS), which is characterized by a thin or absent pituitary stalk, absent or ectopic posterior pituitary, and hypoplasia of the anterior pituitary demonstrated on brain imaging, although this classic triad may be incomplete. Brauner et al. (2020) noted the complex phenotypic and genetic heterogeneity of PSIS, and concluded that it is a feature of genetic disorders or syndromes rather than a specific clinical entity. For a discussion of genetic heterogeneity of combined pituitary hormone deficiency, see CPHD1 (613038).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1841011">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1845412"><div><strong>Diabetes, deafness, developmental delay, and short stature syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1845412</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882732</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Diabetes, deafness, developmental delay, and short stature syndrome (DDDS) is characterized by childhood-onset autoantibody-negative diabetes mellitus and bilateral sensorineural deafness, as well as short stature, microcephaly, and developmental delay (Montaser et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1845412">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347798" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ataxia-hypogonadism-choroidal dystrophy syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1785671" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">BDV syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1808634" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1789612" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Delayed puberty, self-limited</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1845412" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diabetes, deafness, developmental delay, and short stature syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (17)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_295872" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 1 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766757" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 10 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_762090" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 13 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766935" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 16 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863425" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 22 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1806136" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 24 without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1810165" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 27 without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766755" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 8 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333437" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kallmann syndrome with spastic paraplegia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841011" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary hormone deficiency, combined or isolated, 8</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_209236" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary hormone deficiency, combined, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462790" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary hormone deficiency, combined, 6</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/1341460">Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mårin P,
|
||
Krotkiewski M,
|
||
Björntorp P</span><br />
|
||
<span class="medgenPMjournal">Eur J Med</span>
|
||
1992 Oct;1(6):329-36.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1341460" target="_blank">1341460</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2943756">Treatment of hirsutism with a gonadotropin-releasing hormone agonist (nafarelin).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Andreyko JL,
|
||
Monroe SE,
|
||
Jaffe RB</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
1986 Oct;63(4):854-9.
|
||
doi: 10.1210/jcem-63-4-854.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2943756" target="_blank">2943756</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3923027">Treatment of true precocious puberty with a potent luteinizing hormone-releasing factor agonist: effect on growth, sexual maturation, pelvic sonography, and the hypothalamic-pituitary-gonadal axis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Styne DM,
|
||
Harris DA,
|
||
Egli CA,
|
||
Conte FA,
|
||
Kaplan SL,
|
||
Rivier J,
|
||
Vale W,
|
||
Grumbach MM</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
1985 Jul;61(1):142-51.
|
||
doi: 10.1210/jcem-61-1-142.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3923027" target="_blank">3923027</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20circulating%20follicle%20stimulating%20hormone%20concentration)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (6)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38656229">Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bergamini M,
|
||
Dalla Volta A,
|
||
Palumbo C,
|
||
Zamboni S,
|
||
Triggiani L,
|
||
Zamparini M,
|
||
Laganà M,
|
||
Rinaudo L,
|
||
Di Meo N,
|
||
Caramella I,
|
||
Bresciani R,
|
||
Valcamonico F,
|
||
Borghetti P,
|
||
Guerini A,
|
||
Farina D,
|
||
Antonelli A,
|
||
Simeone C,
|
||
Mazziotti G,
|
||
Berruti A</span><br />
|
||
<span class="medgenPMjournal">Elife</span>
|
||
2024 Apr 24;13
|
||
doi: 10.7554/eLife.92655.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38656229" target="_blank">38656229</a><a href="/pmc/articles/PMC11042799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36791677">Rosuvastatin Potentiates Gonadotropin-Lowering Effects of Metformin in Postmenopausal Women: A Pilot Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krysiak R,
|
||
Kowalcze K,
|
||
Okopień B</span><br />
|
||
<span class="medgenPMjournal">Pharmacology</span>
|
||
2023;108(3):245-254.
|
||
Epub 2023 Feb 15
|
||
doi: 10.1159/000528939.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36791677" target="_blank">36791677</a><a href="/pmc/articles/PMC10233706" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35930503">Menopause modulates the circulating metabolome: evidence from a prospective cohort study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karppinen JE,
|
||
Törmäkangas T,
|
||
Kujala UM,
|
||
Sipilä S,
|
||
Laukkanen J,
|
||
Aukee P,
|
||
Kovanen V,
|
||
Laakkonen EK</span><br />
|
||
<span class="medgenPMjournal">Eur J Prev Cardiol</span>
|
||
2022 Aug 5;29(10):1448-1459.
|
||
doi: 10.1093/eurjpc/zwac060.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35930503" target="_blank">35930503</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35244287">Ovarian response to follicle-stimulating hormone in women with polycystic ovary syndrome is diminished compared to ovulatory controls.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harrison TNH,
|
||
Chang RJ</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2022 Sep;97(3):310-318.
|
||
Epub 2022 Mar 14
|
||
doi: 10.1111/cen.14708.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35244287" target="_blank">35244287</a><a href="/pmc/articles/PMC9356979" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32849258">Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao L,
|
||
Pang A</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:428.
|
||
Epub 2020 Aug 11
|
||
doi: 10.3389/fendo.2020.00428.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32849258" target="_blank">32849258</a><a href="/pmc/articles/PMC7431460" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20follicle%20stimulating%20hormone%20concentration%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (90)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39363530">Subclinical Hyperthyroidism Enhances Gonadotropin-Lowering Effects of Metformin in Postmenopausal Women.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krysiak R,
|
||
Kowalcze K,
|
||
Okopień B</span><br />
|
||
<span class="medgenPMjournal">J Clin Pharmacol</span>
|
||
2025 Mar;65(3):318-327.
|
||
Epub 2024 Oct 3
|
||
doi: 10.1002/jcph.6144.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39363530" target="_blank">39363530</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36516786">Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krysiak R,
|
||
Kowalcze K,
|
||
Okopień B</span><br />
|
||
<span class="medgenPMjournal">Gynecol Obstet Invest</span>
|
||
2022;87(6):373-380.
|
||
Epub 2022 Dec 14
|
||
doi: 10.1159/000527365.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36516786" target="_blank">36516786</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32813271">Plasma gonadotropin levels in metformin-treated men with prediabetes: a non-randomized, uncontrolled pilot study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krysiak R,
|
||
Szkróbka W,
|
||
Bednarska-Czerwińska A,
|
||
Okopień B</span><br />
|
||
<span class="medgenPMjournal">Fundam Clin Pharmacol</span>
|
||
2021 Apr;35(2):466-472.
|
||
Epub 2020 Sep 10
|
||
doi: 10.1111/fcp.12600.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32813271" target="_blank">32813271</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19444906">Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McSorley MA,
|
||
Alberg AJ,
|
||
Allen DS,
|
||
Allen NE,
|
||
Brinton LA,
|
||
Dorgan JF,
|
||
Kaaks R,
|
||
Rinaldi S,
|
||
Helzlsouer KJ</span><br />
|
||
<span class="medgenPMjournal">Int J Cancer</span>
|
||
2009 Aug 1;125(3):674-9.
|
||
doi: 10.1002/ijc.24406.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19444906" target="_blank">19444906</a><a href="/pmc/articles/PMC2706295" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2506079">Correlation of sperm-bound immunoglobulins with impaired semen analysis in infertile men with varicoceles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gilbert BR,
|
||
Witkin SS,
|
||
Goldstein M</span><br />
|
||
<span class="medgenPMjournal">Fertil Steril</span>
|
||
1989 Sep;52(3):469-73.
|
||
doi: 10.1016/s0015-0282(16)60921-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2506079" target="_blank">2506079</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20follicle%20stimulating%20hormone%20concentration%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (40)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38656229">Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bergamini M,
|
||
Dalla Volta A,
|
||
Palumbo C,
|
||
Zamboni S,
|
||
Triggiani L,
|
||
Zamparini M,
|
||
Laganà M,
|
||
Rinaudo L,
|
||
Di Meo N,
|
||
Caramella I,
|
||
Bresciani R,
|
||
Valcamonico F,
|
||
Borghetti P,
|
||
Guerini A,
|
||
Farina D,
|
||
Antonelli A,
|
||
Simeone C,
|
||
Mazziotti G,
|
||
Berruti A</span><br />
|
||
<span class="medgenPMjournal">Elife</span>
|
||
2024 Apr 24;13
|
||
doi: 10.7554/eLife.92655.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38656229" target="_blank">38656229</a><a href="/pmc/articles/PMC11042799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36791677">Rosuvastatin Potentiates Gonadotropin-Lowering Effects of Metformin in Postmenopausal Women: A Pilot Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krysiak R,
|
||
Kowalcze K,
|
||
Okopień B</span><br />
|
||
<span class="medgenPMjournal">Pharmacology</span>
|
||
2023;108(3):245-254.
|
||
Epub 2023 Feb 15
|
||
doi: 10.1159/000528939.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36791677" target="_blank">36791677</a><a href="/pmc/articles/PMC10233706" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35244287">Ovarian response to follicle-stimulating hormone in women with polycystic ovary syndrome is diminished compared to ovulatory controls.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harrison TNH,
|
||
Chang RJ</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2022 Sep;97(3):310-318.
|
||
Epub 2022 Mar 14
|
||
doi: 10.1111/cen.14708.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35244287" target="_blank">35244287</a><a href="/pmc/articles/PMC9356979" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32849258">Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao L,
|
||
Pang A</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:428.
|
||
Epub 2020 Aug 11
|
||
doi: 10.3389/fendo.2020.00428.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32849258" target="_blank">32849258</a><a href="/pmc/articles/PMC7431460" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2943106">Modulation of immunoreactive somatomedin-C levels by sex steroids.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caufriez A,
|
||
Golstein J,
|
||
Tadjerouni A,
|
||
Bosson D,
|
||
Cantraine F,
|
||
Robyn C,
|
||
Copinschi G</span><br />
|
||
<span class="medgenPMjournal">Acta Endocrinol (Copenh)</span>
|
||
1986 Jun;112(2):284-9.
|
||
doi: 10.1530/acta.0.1120284.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2943106" target="_blank">2943106</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20follicle%20stimulating%20hormone%20concentration%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (77)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32506336">Neoadjuvant chemotherapy modifies serum pyrrolidone carboxypeptidase specific activity in women with breast cancer and influences circulating levels of GnRH and gonadotropins.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ramírez-Expósito MJ,
|
||
Martínez-Martos JM,
|
||
Dueñas-Rodríguez B,
|
||
Navarro-Cecilia J,
|
||
Carrera-González MP</span><br />
|
||
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
|
||
2020 Aug;182(3):751-760.
|
||
Epub 2020 Jun 6
|
||
doi: 10.1007/s10549-020-05723-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32506336" target="_blank">32506336</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24241787">Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Johansson H,
|
||
Bonanni B,
|
||
Gandini S,
|
||
Guerrieri-Gonzaga A,
|
||
Cazzaniga M,
|
||
Serrano D,
|
||
Macis D,
|
||
Puccio A,
|
||
Sandri MT,
|
||
Gulisano M,
|
||
Formelli F,
|
||
Decensi A</span><br />
|
||
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
|
||
2013 Dec;142(3):569-78.
|
||
Epub 2013 Nov 17
|
||
doi: 10.1007/s10549-013-2768-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24241787" target="_blank">24241787</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19444906">Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McSorley MA,
|
||
Alberg AJ,
|
||
Allen DS,
|
||
Allen NE,
|
||
Brinton LA,
|
||
Dorgan JF,
|
||
Kaaks R,
|
||
Rinaldi S,
|
||
Helzlsouer KJ</span><br />
|
||
<span class="medgenPMjournal">Int J Cancer</span>
|
||
2009 Aug 1;125(3):674-9.
|
||
doi: 10.1002/ijc.24406.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19444906" target="_blank">19444906</a><a href="/pmc/articles/PMC2706295" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16471143">The biological aspects of risks of infertility due to age: the female side.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gougeon A</span><br />
|
||
<span class="medgenPMjournal">Rev Epidemiol Sante Publique</span>
|
||
2005 Nov;53 Spec No 2:2S37-45.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16471143" target="_blank">16471143</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2124095">Changes in circulating hormone levels after ovarian wedge resection in patients with polycystic ovary syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szilágyi A,
|
||
Rossmanith W,
|
||
Csermely T,
|
||
Csaba I</span><br />
|
||
<span class="medgenPMjournal">Arch Gynecol Obstet</span>
|
||
1990;248(1):31-5.
|
||
doi: 10.1007/BF02389587.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2124095" target="_blank">2124095</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20follicle%20stimulating%20hormone%20concentration%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38656229">Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bergamini M,
|
||
Dalla Volta A,
|
||
Palumbo C,
|
||
Zamboni S,
|
||
Triggiani L,
|
||
Zamparini M,
|
||
Laganà M,
|
||
Rinaudo L,
|
||
Di Meo N,
|
||
Caramella I,
|
||
Bresciani R,
|
||
Valcamonico F,
|
||
Borghetti P,
|
||
Guerini A,
|
||
Farina D,
|
||
Antonelli A,
|
||
Simeone C,
|
||
Mazziotti G,
|
||
Berruti A</span><br />
|
||
<span class="medgenPMjournal">Elife</span>
|
||
2024 Apr 24;13
|
||
doi: 10.7554/eLife.92655.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38656229" target="_blank">38656229</a><a href="/pmc/articles/PMC11042799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36791677">Rosuvastatin Potentiates Gonadotropin-Lowering Effects of Metformin in Postmenopausal Women: A Pilot Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krysiak R,
|
||
Kowalcze K,
|
||
Okopień B</span><br />
|
||
<span class="medgenPMjournal">Pharmacology</span>
|
||
2023;108(3):245-254.
|
||
Epub 2023 Feb 15
|
||
doi: 10.1159/000528939.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36791677" target="_blank">36791677</a><a href="/pmc/articles/PMC10233706" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36516786">Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krysiak R,
|
||
Kowalcze K,
|
||
Okopień B</span><br />
|
||
<span class="medgenPMjournal">Gynecol Obstet Invest</span>
|
||
2022;87(6):373-380.
|
||
Epub 2022 Dec 14
|
||
doi: 10.1159/000527365.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36516786" target="_blank">36516786</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8606941">Implication of inhibin and related proteins in fetal development.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jenkin G,
|
||
McFarlane JR,
|
||
de Kretser DM</span><br />
|
||
<span class="medgenPMjournal">Reprod Fertil Dev</span>
|
||
1995;7(3):323-31.
|
||
doi: 10.1071/rd9950323.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8606941" target="_blank">8606941</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/568043">The disappearance of HCG and return of pituitary function after abortion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lähteenmäki P</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
1978 Aug;9(2):101-12.
|
||
doi: 10.1111/j.1365-2265.1978.tb02188.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/568043" target="_blank">568043</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20follicle%20stimulating%20hormone%20concentration%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (75)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/32849258">Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao L,
|
||
Pang A</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:428.
|
||
Epub 2020 Aug 11
|
||
doi: 10.3389/fendo.2020.00428.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32849258" target="_blank">32849258</a><a href="/pmc/articles/PMC7431460" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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