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<!--
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||
UID=871167
|
||
ConceptID=C4025641
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased pyruvate carboxylase activity</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>871167</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4025641</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0003209">HP:0003209</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">A decreased rate of pyruvate carboxylase activity. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased pyruvate carboxylase activity</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867398" ref="tree=MeSH" title="MedGen record for Abnormality of metabolism/homeostasis">Abnormality of metabolism/homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/1841674" ref="tree=MeSH" title="MedGen record for Abnormal enzyme concentration or activity">Abnormal enzyme concentration or activity</a></span><ul><li><span class="TLline"><a href="/medgen/1841554" ref="tree=MeSH" title="MedGen record for Abnormal circulating enzyme concentration or activity">Abnormal circulating enzyme concentration or activity</a></span><ul><li><span class="TLline"><a href="/medgen/867422" ref="tree=MeSH" title="MedGen record for Abnormality of Krebs cycle metabolism">Abnormality of Krebs cycle metabolism</a></span><ul><li><span class="matched_ds">Decreased pyruvate carboxylase activity</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_383962"><div><strong>Friedreich ataxia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>383962</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1856689</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Typical Friedreich ataxia (FRDA) is characterized by progressive ataxia with onset from early childhood to early adulthood with mean age at onset from 10 to 15 years (range: age two years to the eighth decade). Ataxia, manifesting initially as poor balance when walking, is typically followed by upper-limb ataxia, dysarthria, dysphagia, peripheral motor and sensory neuropathy, spasticity, autonomic disturbance, and often abnormal eye movements and optic atrophy. Hypertrophic cardiomyopathy is present in about two thirds of individuals; occasionally it is diagnosed prior to the onset of ataxia. Diabetes mellitus and impaired glucose tolerance can also occur. Among individuals with FRDA, about 75% have "typical Friedreich ataxia" and about 25% of individuals with biallelic FXN full-penetrance GAA repeat expansions have "atypical Friedreich ataxia" that includes late-onset FRDA (LOFA) (i.e., onset after age 25 years), very late-onset FRDA (VLOFA) (i.e., onset after age 40 years), and FRDA with retained reflexes (FARR).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/383962">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_356134"><div><strong>Friedreich ataxia 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>356134</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1865981</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Typical Friedreich ataxia (FRDA) is characterized by progressive ataxia with onset from early childhood to early adulthood with mean age at onset from 10 to 15 years (range: age two years to the eighth decade). Ataxia, manifesting initially as poor balance when walking, is typically followed by upper-limb ataxia, dysarthria, dysphagia, peripheral motor and sensory neuropathy, spasticity, autonomic disturbance, and often abnormal eye movements and optic atrophy. Hypertrophic cardiomyopathy is present in about two thirds of individuals; occasionally it is diagnosed prior to the onset of ataxia. Diabetes mellitus and impaired glucose tolerance can also occur. Among individuals with FRDA, about 75% have "typical Friedreich ataxia" and about 25% of individuals with biallelic FXN full-penetrance GAA repeat expansions have "atypical Friedreich ataxia" that includes late-onset FRDA (LOFA) (i.e., onset after age 25 years), very late-onset FRDA (VLOFA) (i.e., onset after age 40 years), and FRDA with retained reflexes (FARR).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/356134">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_383962" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Friedreich ataxia 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_356134" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Friedreich ataxia 2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/8666138">Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">MacDonald MJ,
|
||
Efendić S,
|
||
Ostenson CG</span><br />
|
||
<span class="medgenPMjournal">Diabetes</span>
|
||
1996 Jul;45(7):886-90.
|
||
doi: 10.2337/diab.45.7.886.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8666138" target="_blank">8666138</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20pyruvate%20carboxylase%20activity)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37270169">Inhibition of pyruvate carboxylase reverses metformin resistance by activating AMPK in pancreatic cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu C,
|
||
Zhou X,
|
||
Ju H,
|
||
Zhang Y</span><br />
|
||
<span class="medgenPMjournal">Life Sci</span>
|
||
2023 Aug 15;327:121817.
|
||
Epub 2023 Jun 2
|
||
doi: 10.1016/j.lfs.2023.121817.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37270169" target="_blank">37270169</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31931141">APOE alters glucose flux through central carbon pathways in astrocytes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Williams HC,
|
||
Farmer BC,
|
||
Piron MA,
|
||
Walsh AE,
|
||
Bruntz RC,
|
||
Gentry MS,
|
||
Sun RC,
|
||
Johnson LA</span><br />
|
||
<span class="medgenPMjournal">Neurobiol Dis</span>
|
||
2020 Mar;136:104742.
|
||
Epub 2020 Jan 11
|
||
doi: 10.1016/j.nbd.2020.104742.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31931141" target="_blank">31931141</a><a href="/pmc/articles/PMC7044721" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27187341">The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zheng X,
|
||
Ke Y,
|
||
Feng A,
|
||
Yuan P,
|
||
Zhou J,
|
||
Yu Y,
|
||
Wang X,
|
||
Feng W</span><br />
|
||
<span class="medgenPMjournal">Molecules</span>
|
||
2016 May 13;21(5)
|
||
doi: 10.3390/molecules21050624.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27187341" target="_blank">27187341</a><a href="/pmc/articles/PMC6274486" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24376351">In vitro cytotoxicity of the ternary PAMAM G3-pyridoxal-biotin bioconjugate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Uram Ł,
|
||
Szuster M,
|
||
Gargasz K,
|
||
Filipowicz A,
|
||
Wałajtys-Rode E,
|
||
Wołowiec S</span><br />
|
||
<span class="medgenPMjournal">Int J Nanomedicine</span>
|
||
2013;8:4707-20.
|
||
Epub 2013 Dec 11
|
||
doi: 10.2147/IJN.S53254.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24376351" target="_blank">24376351</a><a href="/pmc/articles/PMC3864882" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14503847">Bcl-2 inhibits tumor necrosis factor-alpha-mediated increase of glycolytic enzyme activities and enhances pyruvate carboxylase activity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim YH,
|
||
Kim SS</span><br />
|
||
<span class="medgenPMjournal">Mol Cells</span>
|
||
2003 Aug 31;16(1):67-73.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14503847" target="_blank">14503847</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20pyruvate%20carboxylase%20activity%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (14)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37270169">Inhibition of pyruvate carboxylase reverses metformin resistance by activating AMPK in pancreatic cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu C,
|
||
Zhou X,
|
||
Ju H,
|
||
Zhang Y</span><br />
|
||
<span class="medgenPMjournal">Life Sci</span>
|
||
2023 Aug 15;327:121817.
|
||
Epub 2023 Jun 2
|
||
doi: 10.1016/j.lfs.2023.121817.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37270169" target="_blank">37270169</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26272431">H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ju Y,
|
||
Untereiner A,
|
||
Wu L,
|
||
Yang G</span><br />
|
||
<span class="medgenPMjournal">Biochim Biophys Acta</span>
|
||
2015 Nov;1850(11):2293-303.
|
||
Epub 2015 Aug 11
|
||
doi: 10.1016/j.bbagen.2015.08.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26272431" target="_blank">26272431</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15479216">Effects of dietary fatty acids on insulin sensitivity and secretion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manco M,
|
||
Calvani M,
|
||
Mingrone G</span><br />
|
||
<span class="medgenPMjournal">Diabetes Obes Metab</span>
|
||
2004 Nov;6(6):402-13.
|
||
doi: 10.1111/j.1462-8902.2004.00356.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15479216" target="_blank">15479216</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12214565">Biotin-dependent carboxylase activities in different CNS and skin-derived cells, and their sensitivity to biotin-depletion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Suormala T,
|
||
Wiesmann UN,
|
||
Cruz F,
|
||
Wolf A,
|
||
Daschner M,
|
||
Limat A,
|
||
Fowler B,
|
||
Baumgartner ER</span><br />
|
||
<span class="medgenPMjournal">Int J Vitam Nutr Res</span>
|
||
2002 Jul;72(4):278-86.
|
||
doi: 10.1024/0300-9831.72.4.278.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12214565" target="_blank">12214565</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1329789">Leigh encephalopathy: histologic and biochemical analyses of muscle biopsies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nagai T,
|
||
Goto Y,
|
||
Matsuoka T,
|
||
Sakuta R,
|
||
Naito E,
|
||
Kuroda Y,
|
||
Nonaka I</span><br />
|
||
<span class="medgenPMjournal">Pediatr Neurol</span>
|
||
1992 Sep-Oct;8(5):328-32.
|
||
doi: 10.1016/0887-8994(92)90084-c.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1329789" target="_blank">1329789</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20pyruvate%20carboxylase%20activity%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (16)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39177932">Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gunasekharan V,
|
||
Lin HK,
|
||
Marczyk M,
|
||
Rios-Hoyo A,
|
||
Campos GE,
|
||
Shan NL,
|
||
Ahmed M,
|
||
Umlauf S,
|
||
Gareiss P,
|
||
Raaisa R,
|
||
Williams R,
|
||
Cardone R,
|
||
Siebel S,
|
||
Kibbey R,
|
||
Surovtseva YV,
|
||
Pusztai L</span><br />
|
||
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
|
||
2024 Dec;208(3):657-671.
|
||
Epub 2024 Aug 23
|
||
doi: 10.1007/s10549-024-07462-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39177932" target="_blank">39177932</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34324855">Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li SY,
|
||
Shang J,
|
||
Mao XM,
|
||
Fan R,
|
||
Li HQ,
|
||
Li RH,
|
||
Shen DY</span><br />
|
||
<span class="medgenPMjournal">Eur J Pharmacol</span>
|
||
2021 Oct 5;908:174370.
|
||
Epub 2021 Jul 27
|
||
doi: 10.1016/j.ejphar.2021.174370.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34324855" target="_blank">34324855</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27187341">The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zheng X,
|
||
Ke Y,
|
||
Feng A,
|
||
Yuan P,
|
||
Zhou J,
|
||
Yu Y,
|
||
Wang X,
|
||
Feng W</span><br />
|
||
<span class="medgenPMjournal">Molecules</span>
|
||
2016 May 13;21(5)
|
||
doi: 10.3390/molecules21050624.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27187341" target="_blank">27187341</a><a href="/pmc/articles/PMC6274486" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25607840">Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sellers K,
|
||
Fox MP,
|
||
Bousamra M 2nd,
|
||
Slone SP,
|
||
Higashi RM,
|
||
Miller DM,
|
||
Wang Y,
|
||
Yan J,
|
||
Yuneva MO,
|
||
Deshpande R,
|
||
Lane AN,
|
||
Fan TW</span><br />
|
||
<span class="medgenPMjournal">J Clin Invest</span>
|
||
2015 Feb;125(2):687-98.
|
||
Epub 2015 Jan 20
|
||
doi: 10.1172/JCI72873.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25607840" target="_blank">25607840</a><a href="/pmc/articles/PMC4319441" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23886814">Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mori J,
|
||
Zhang L,
|
||
Oudit GY,
|
||
Lopaschuk GD</span><br />
|
||
<span class="medgenPMjournal">J Mol Cell Cardiol</span>
|
||
2013 Oct;63:98-106.
|
||
Epub 2013 Jul 22
|
||
doi: 10.1016/j.yjmcc.2013.07.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23886814" target="_blank">23886814</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20pyruvate%20carboxylase%20activity%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27992582">Dietary Macronutrient Composition Directs ChREBP Isoform Expression and Glucose Metabolism in Mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jois T,
|
||
Howard V,
|
||
Youngs K,
|
||
Cowley MA,
|
||
Sleeman MW</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2016;11(12):e0168797.
|
||
Epub 2016 Dec 19
|
||
doi: 10.1371/journal.pone.0168797.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27992582" target="_blank">27992582</a><a href="/pmc/articles/PMC5167554" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20409457">Ensemble modeling of hepatic fatty acid metabolism with a synthetic glyoxylate shunt.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dean JT,
|
||
Rizk ML,
|
||
Tan Y,
|
||
Dipple KM,
|
||
Liao JC</span><br />
|
||
<span class="medgenPMjournal">Biophys J</span>
|
||
2010 Apr 21;98(8):1385-95.
|
||
doi: 10.1016/j.bpj.2009.12.4308.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20409457" target="_blank">20409457</a><a href="/pmc/articles/PMC2856160" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8072427">Promotion of hepatic lipid oxidation and gluconeogenesis as a strategy for appetite control.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McCarty MF</span><br />
|
||
<span class="medgenPMjournal">Med Hypotheses</span>
|
||
1994 Apr;42(4):215-25.
|
||
doi: 10.1016/0306-9877(94)90120-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8072427" target="_blank">8072427</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/412860">The clinical and biochemical implications of pyruvate carboxylase deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">DeVivo DC,
|
||
Haymond MW,
|
||
Leckie MP,
|
||
Bussman YL,
|
||
McDougal DB Jr,
|
||
Pagliara AS</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
1977 Dec;45(6):1281-96.
|
||
doi: 10.1210/jcem-45-6-1281.
|
||
<span class="bold">PMID: </span><a href="/pubmed/412860" target="_blank">412860</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/826106">Neonatal congenital lactic acidosis with pyruvate carboxylase deficiency in two siblings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saudubray JM,
|
||
Marsac C,
|
||
Cathelineau CL,
|
||
Besson Leaud M,
|
||
Leroux JP</span><br />
|
||
<span class="medgenPMjournal">Acta Paediatr Scand</span>
|
||
1976 Nov;65(6):717-24.
|
||
doi: 10.1111/j.1651-2227.1976.tb18009.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/826106" target="_blank">826106</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20pyruvate%20carboxylase%20activity%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39473004">Circ-CAMTA1 regulated by Ca(2+) influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu HC,
|
||
Tseng HH,
|
||
Huang HB,
|
||
Lu MC</span><br />
|
||
<span class="medgenPMjournal">Arthritis Res Ther</span>
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||
2024 Oct 29;26(1):185.
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||
doi: 10.1186/s13075-024-03422-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39473004" target="_blank">39473004</a><a href="/pmc/articles/PMC11520813" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35639425">Mitochondrial phosphatidylethanolamine synthesis affects mitochondrial energy metabolism and quiescence entry through attenuation of Snf1/AMPK signaling in yeast.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Miyata N,
|
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Ito T,
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Nakashima M,
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Fujii S,
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Kuge O</span><br />
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<span class="medgenPMjournal">FASEB J</span>
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2022 Jul;36(7):e22355.
|
||
doi: 10.1096/fj.202101600RR.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35639425" target="_blank">35639425</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/34158007">Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu C,
|
||
Zhou X,
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||
Pan Y,
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||
Liu Y,
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Zhang Y</span><br />
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<span class="medgenPMjournal">BMC Cancer</span>
|
||
2021 Jun 22;21(1):722.
|
||
doi: 10.1186/s12885-021-08499-9.
|
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<span class="bold">PMID: </span><a href="/pubmed/34158007" target="_blank">34158007</a><a href="/pmc/articles/PMC8220755" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31931141">APOE alters glucose flux through central carbon pathways in astrocytes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Williams HC,
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Farmer BC,
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Piron MA,
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Walsh AE,
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Bruntz RC,
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Gentry MS,
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Sun RC,
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Johnson LA</span><br />
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<span class="medgenPMjournal">Neurobiol Dis</span>
|
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2020 Mar;136:104742.
|
||
Epub 2020 Jan 11
|
||
doi: 10.1016/j.nbd.2020.104742.
|
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<span class="bold">PMID: </span><a href="/pubmed/31931141" target="_blank">31931141</a><a href="/pmc/articles/PMC7044721" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/15992686">Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mock DM</span><br />
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<span class="medgenPMjournal">J Nutr Biochem</span>
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2005 Jul;16(7):435-7.
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doi: 10.1016/j.jnutbio.2005.03.022.
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