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<meta name="keywords" content="C4025282, finding, impaired adp-induced platelet aggregation, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Abnormal platelet response to ADP as manifested by reduced or lacking aggregation of platelets upon addition of ADP." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=870824
|
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ConceptID=C4025282
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Impaired ADP-induced platelet aggregation</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>870824</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4025282</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004866">HP:0004866</a></td></tr>
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<div class="portlet_content ln">Abnormal platelet response to ADP as manifested by reduced or lacking aggregation of platelets upon addition of ADP. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4025282[DISCUI]&test_type=Clinical" ref="ncbi_uid=870824">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=870824" ref="ncbi_uid=870824">V</a></span></span><span class="TLline">Impaired ADP-induced platelet aggregation</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/163092" ref="tree=MeSH" title="MedGen record for Abnormality of blood and blood-forming tissues">Abnormality of blood and blood-forming tissues</a></span><ul><li><span class="TLline"><a href="/medgen/57492" ref="tree=MeSH" title="MedGen record for Abnormality of thrombocytes">Abnormality of thrombocytes</a></span><ul><li><span class="TLline"><a href="/medgen/488944" ref="tree=MeSH" title="MedGen record for Abnormal platelet function">Abnormal platelet function</a></span><ul><li><span class="TLline"><a href="/medgen/154224" ref="tree=MeSH" title="MedGen record for Abnormal platelet aggregation">Abnormal platelet aggregation</a></span><ul><li><span class="TLline"><a href="/medgen/383786" ref="tree=MeSH" title="MedGen record for Impaired platelet aggregation">Impaired platelet aggregation</a></span><ul><li><span class="matched_ds">Impaired ADP-induced platelet aggregation</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_52736"><div><strong>Glanzmann thrombasthenia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>52736</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0040015</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Glanzmann thrombasthenia is a bleeding disorder that is characterized by prolonged or spontaneous bleeding starting from birth. People with Glanzmann thrombasthenia tend to bruise easily, have frequent nosebleeds (epistaxis), and may bleed from the gums. They may also develop red or purple spots on the skin caused by bleeding underneath the skin (petechiae) or swelling caused by bleeding within tissues (hematoma). Glanzmann thrombasthenia can also cause prolonged bleeding following injury, trauma, or surgery (including dental work). Women with this condition can have prolonged and sometimes abnormally heavy menstrual bleeding. Affected women also have an increased risk of excessive blood loss during pregnancy and childbirth.\n\nAbout a quarter of individuals with Glanzmann thrombasthenia have bleeding in the gastrointestinal tract, which often occurs later in life. Rarely, affected individuals have bleeding inside the skull (intracranial hemorrhage) or joints (hemarthrosis).\n\nThe severity and frequency of the bleeding episodes in Glanzmann thrombasthenia can vary greatly among affected individuals, even in the same family. Spontaneous bleeding tends to become less frequent with age.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/52736">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_321945"><div><strong>Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>321945</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832388</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">RUNX1 familial platelet disorder with associated myeloid malignancies (RUNX1-FPDMM) is characterized by prolonged bleeding and/or easy bruising and an increased risk of developing a hematologic malignancy. RUNX1-FPDMM is characterized by thrombocytopenia with normal platelet size; bleeding is often greater than expected due to qualitative platelet dysfunction. Myeloid malignancies are the most common, including acute myelogenous leukemia and myelodysplastic syndrome. T- and B-cell acute lymphoblastic leukemias and lymphomas have also been reported, as well as skin manifestations (e.g., eczema, psoriasis).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/321945">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_374912"><div><strong>Hermansky-Pudlak syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>374912</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1842362</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, and/or immunodeficiency. Ocular findings include nystagmus, reduced iris pigment, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), and strabismus in many individuals. Hair color ranges from white to brown; skin color ranges from white to olive and is usually at least a shade lighter than that of other family members. The bleeding diathesis can result in variable degrees of bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and/or other surgeries. Pulmonary fibrosis, colitis, and/or neutropenia have been reported in individuals with pathogenic variants in some HPS-related genes. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early 30s and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/374912">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_344008"><div><strong>Platelet-type bleeding disorder 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344008</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1853278</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Platelet-type bleeding disorder-8 (BDPLT8) is an autosomal recessive condition characterized by mild to moderate mucocutaneous bleeding and excessive bleeding after surgery or trauma. The defect is due to the inability of ADP to induce platelet aggregation (review by Cattaneo, 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/344008">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_357448"><div><strong>Platelet signal processing defect</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>357448</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1868199</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/357448">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_478706"><div><strong>Bernard-Soulier syndrome, type A2, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>478706</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3277076</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant Bernard-Soulier syndrome type A2 (BSSA2) is characterized by chronic macrothrombocytopenia with mild or no clinical symptoms, normal platelet function, and normal megakaryocyte count. When present, clinical findings include excessive ecchymoses, frequent epistaxis, gingival bleeding, prolonged menstrual periods, or prolonged bleeding after tooth extraction (Savoia et al., 2001). Genetic Heterogeneity of Bernard-Soulier Syndrome Homozygous or compound heterozygous mutations in the GP1BA gene cause classic autosomal recessive Bernard-Soulier syndrome (BSSA1; 231200).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/478706">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_479301"><div><strong>Thrombocythemia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>479301</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3277671</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Thrombocythemia, or thrombocytosis, is a myeloproliferative disorder characterized by excessive platelet production resulting in increased numbers of circulating platelets. Thrombocythemia can be associated with thrombotic or hemorrhagic episodes and occasional leukemic transformation (summary by Wiestner et al., 1998). Genetic Heterogeneity of Thrombocythemia THCYT2 (601977) is caused by germline or somatic mutation in the THPO receptor gene (MPL; 159530) on chromosome 1p34, and THCYT3 (614521) is caused by germline or somatic mutation in the JAK2 gene (147796) on chromosome 9p. Somatic mutations in the TET2 (612839), ASXL1 (612990), SH2B3 (605093), and SF3B1 (605590) genes have also been found in cases of essential thrombocythemia. Somatic mutation in the CALR gene (109091) occurs in approximately 70% of essential thrombocythemia patients who lack JAK2 and MPL mutations (Klampfl et al., 2013; Nangalia et al., 2013).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/479301">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767577"><div><strong>Platelet-type bleeding disorder 15</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767577</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554663</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Platelet-type bleeding disorder-15 is an autosomal dominant form of macrothrombocytopenia. Affected individuals usually have no or only mild bleeding tendency, such as epistaxis. Laboratory studies show decreased numbers of large platelets and anisocytosis, but the platelets show no in vitro functional abnormalities (summary by Kunishima et al., 2013).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767577">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_854711"><div><strong>Hermansky-Pudlak syndrome 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854711</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3888004</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, and/or immunodeficiency. Ocular findings include nystagmus, reduced iris pigment, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), and strabismus in many individuals. Hair color ranges from white to brown; skin color ranges from white to olive and is usually at least a shade lighter than that of other family members. The bleeding diathesis can result in variable degrees of bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and/or other surgeries. Pulmonary fibrosis, colitis, and/or neutropenia have been reported in individuals with pathogenic variants in some HPS-related genes. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early 30s and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/854711">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_854714"><div><strong>Hermansky-Pudlak syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854714</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3888007</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, and/or immunodeficiency. Ocular findings include nystagmus, reduced iris pigment, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), and strabismus in many individuals. Hair color ranges from white to brown; skin color ranges from white to olive and is usually at least a shade lighter than that of other family members. The bleeding diathesis can result in variable degrees of bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and/or other surgeries. Pulmonary fibrosis, colitis, and/or neutropenia have been reported in individuals with pathogenic variants in some HPS-related genes. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early 30s and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/854714">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863021"><div><strong>Platelet-type bleeding disorder 18</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863021</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014584</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bleeding disorder due to CalDAG-GEFI deficiency is a rare hematologic disease due to defective platelet function and characterized by mucocutaneous bleeding starting in infancy (around 18 months of age), presenting with prolonged and severe epistaxis, hematomas and bleeding after tooth extraction. Massive menorrhagia and chronic anemia have also been reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863021">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1386863"><div><strong>Bleeding disorder, platelet-type, 21</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1386863</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4479515</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">BDPLT21 is a hematologic disorder characterized by increased risk of bleeding resulting from a functional platelet defect. Platelets have decreased or even absent dense bodies and abnormally enlarged and fused alpha-granules, and they show defective secretion and aggregation responses to agonists. Platelets are usually enlarged, and some patients may have mild to moderate thrombocytopenia (summary by Saultier et al., 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1386863">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1673822"><div><strong>Bleeding disorder, platelet-type, 22</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1673822</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193111</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Platelet-type bleeding disorder-22 (BDPLT22) is an autosomal recessive bleeding disorder resulting from impaired platelet aggregation due to intracellular signaling defects. Patients present in the first decade with spontaneous subcutaneous bleeding and excessive bleeding after minor injuries. Platelet counts are usually normal, although platelets show abnormal morphology (summary by Berrou et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1673822">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1704278"><div><strong>Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1704278</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5200934</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">MYH9-related disease (MYH9-RD) is characterized in all affected individuals by hematologic features present from birth consisting of platelet macrocytosis (i.e., >40% of platelets larger than 3.9 µm in diameter), thrombocytopenia (platelet count <150 x 109/L), and aggregates of the MYH9 protein in the cytoplasm of neutrophil granulocytes. Most affected individuals develop one or more additional extrahematologic manifestations of the disease over their lifetime, including sensorineural hearing loss, renal disease (manifesting initially as glomerular nephropathy), presenile cataracts, and/or elevation of liver enzymes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1704278">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1768257"><div><strong>Thrombocytopenia 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1768257</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436874</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Thrombocytopenia-7 (THC7) is an autosomal dominant disorder characterized by reduced peripheral platelet count. The expression and severity of the disorder is highly variable: some patients have no bleeding symptoms, whereas other have recurrent petechiae, epistaxis, or more severe bleeding episodes. A common finding is decreased alpha-granules in the platelets. There are variable findings on light and electron microscopic analysis: some patients have normal platelet morphology, whereas others show abnormal platelet morphology with cytoskeletal defects. Flow cytometric studies may show reduced expression of platelet membrane glycoproteins and activation markers (summary by Lentaigne et al., 2019 and Leinoe et al., 2021). For a general phenotypic description and a discussion of genetic heterogeneity of thrombocytopenia, see 313900.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1768257">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1782592"><div><strong>Glanzmann thrombasthenia 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1782592</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543273</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Glanzmann thrombasthenia-2 (GT2) is an autosomal recessive bleeding disorder characterized by failure of platelet aggregation and by absent or diminished clot retraction. The abnormalities are related to quantitative or qualitative abnormalities of the GPIIb (607759)/IIIa platelet surface fibrinogen receptor complex resulting from mutations in the GPIIIa gene (Rosenberg et al., 1997). For a general phenotypic description and a discussion of genetic heterogeneity of Glanzmann thrombasthenia, see 273800.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1782592">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1785711"><div><strong>Bleeding disorder, platelet-type, 24</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1785711</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543280</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Platelet-type bleeding disorder-24 (BDPLT24) is an autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities (summary by Kunishima et al., 2011 and Nurden et al., 2011). For a discussion of genetic heterogeneity of Glanzmann thrombasthenia-like with macrothrombocytopenia, see 187800.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1785711">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1846290"><div><strong>Bleeding disorder, platelet-type, 25</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1846290</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882683</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Platelet-type bleeding disorder-25 (BDPLT25) is an autosomal dominant condition characterized by increased susceptibility to bleeding episodes due to decreased or dysfunctional platelets. Some individuals have decreased numbers of enlarged platelets or macrothrombocytopenia, whereas others have normal numbers of enlarged platelets. Platelet morphologic and functional defects are variable (Pleines et al., 2017; Stapley et al., 2022; Marin-Quilez et al., 2022). For a discussion of genetic heterogeneity of BDPLT, see 231200.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1846290">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_478706" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bernard-Soulier syndrome, type A2, autosomal dominant</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1386863" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bleeding disorder, platelet-type, 21</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1673822" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bleeding disorder, platelet-type, 22</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1785711" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bleeding disorder, platelet-type, 24</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1846290" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bleeding disorder, platelet-type, 25</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (18)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_52736" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glanzmann thrombasthenia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1782592" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glanzmann thrombasthenia 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_321945" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_374912" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hermansky-Pudlak syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_854711" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hermansky-Pudlak syndrome 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_854714" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hermansky-Pudlak syndrome 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1704278" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_357448" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Platelet signal processing defect</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767577" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Platelet-type bleeding disorder 15</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863021" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Platelet-type bleeding disorder 18</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344008" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Platelet-type bleeding disorder 8</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_479301" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thrombocythemia 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1768257" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thrombocytopenia 7</a></div></span></div></div>
|
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</div>
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<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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||
<div class="nl"><a target="_blank" href="/pubmed/10806831">Effect of low HDL combined with hypertriglyceridemia in coronary artery disease patients on PGI2 biological activity in relation to lipid regulating treatment.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Li J,
|
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Dai G,
|
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Feng Z,
|
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Wang C,
|
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Yang Y,
|
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Wei W,
|
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Zhou B</span><br />
|
||
<span class="medgenPMjournal">J Tongji Med Univ</span>
|
||
1998;18(2):87-9, 93.
|
||
doi: 10.1007/BF02888473.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10806831" target="_blank">10806831</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(impaired%20adp-induced%20platelet%20aggregation)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38721951">The prognostic value of platelet aggregation in patients with sepsis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen T,
|
||
Yang H,
|
||
Zhao Z,
|
||
Wang H,
|
||
Zhong S</span><br />
|
||
<span class="medgenPMjournal">Allergol Immunopathol (Madr)</span>
|
||
2024;52(3):17-21.
|
||
Epub 2024 May 1
|
||
doi: 10.15586/aei.v52i3.1039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38721951" target="_blank">38721951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36825598">The evolving knowledge on primary hemostasis in patients with cirrhosis: A comprehensive review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zanetto A,
|
||
Campello E,
|
||
Senzolo M,
|
||
Simioni P</span><br />
|
||
<span class="medgenPMjournal">Hepatology</span>
|
||
2024 Feb 1;79(2):460-481.
|
||
Epub 2023 Feb 27
|
||
doi: 10.1097/HEP.0000000000000349.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36825598" target="_blank">36825598</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37589138">Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brambilla M,
|
||
Becchetti A,
|
||
Rovati GE,
|
||
Cosentino N,
|
||
Conti M,
|
||
Canzano P,
|
||
Giesen PLA,
|
||
Loffreda A,
|
||
Bonomi A,
|
||
Cattaneo M,
|
||
De Candia E,
|
||
Podda GM,
|
||
Trabattoni D,
|
||
Werba PJ,
|
||
Campodonico J,
|
||
Pinna C,
|
||
Marenzi G,
|
||
Tremoli E,
|
||
Camera M</span><br />
|
||
<span class="medgenPMjournal">Arterioscler Thromb Vasc Biol</span>
|
||
2023 Oct;43(10):2042-2057.
|
||
Epub 2023 Aug 17
|
||
doi: 10.1161/ATVBAHA.123.319099.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37589138" target="_blank">37589138</a><a href="/pmc/articles/PMC10521789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35325455">Does platelet aggregation have any importance in fetal growth restriction pregnancies?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Misan N,
|
||
Burchardt B,
|
||
Korszun P,
|
||
Kapska K,
|
||
Kapska J,
|
||
Kawka-Paciorkowska K,
|
||
Ropacka-Lesiak M</span><br />
|
||
<span class="medgenPMjournal">Ginekol Pol</span>
|
||
2022;93(12):968-974.
|
||
Epub 2022 Mar 24
|
||
doi: 10.5603/GP.a2022.0006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35325455" target="_blank">35325455</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29577968">Glucocorticoids impair platelet thromboxane biosynthesis in community-acquired pneumonia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cangemi R,
|
||
Carnevale R,
|
||
Nocella C,
|
||
Calvieri C,
|
||
Cammisotto V,
|
||
Novo M,
|
||
Castellani V,
|
||
D'Amico A,
|
||
Zerbinati C,
|
||
Stefanini L,
|
||
Violi F;
|
||
SIXTUS Study Group</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Res</span>
|
||
2018 May;131:66-74.
|
||
Epub 2018 Mar 22
|
||
doi: 10.1016/j.phrs.2018.03.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29577968" target="_blank">29577968</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20ADP-induced%20platelet%20aggregation%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (49)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38721951">The prognostic value of platelet aggregation in patients with sepsis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen T,
|
||
Yang H,
|
||
Zhao Z,
|
||
Wang H,
|
||
Zhong S</span><br />
|
||
<span class="medgenPMjournal">Allergol Immunopathol (Madr)</span>
|
||
2024;52(3):17-21.
|
||
Epub 2024 May 1
|
||
doi: 10.15586/aei.v52i3.1039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38721951" target="_blank">38721951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37589138">Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brambilla M,
|
||
Becchetti A,
|
||
Rovati GE,
|
||
Cosentino N,
|
||
Conti M,
|
||
Canzano P,
|
||
Giesen PLA,
|
||
Loffreda A,
|
||
Bonomi A,
|
||
Cattaneo M,
|
||
De Candia E,
|
||
Podda GM,
|
||
Trabattoni D,
|
||
Werba PJ,
|
||
Campodonico J,
|
||
Pinna C,
|
||
Marenzi G,
|
||
Tremoli E,
|
||
Camera M</span><br />
|
||
<span class="medgenPMjournal">Arterioscler Thromb Vasc Biol</span>
|
||
2023 Oct;43(10):2042-2057.
|
||
Epub 2023 Aug 17
|
||
doi: 10.1161/ATVBAHA.123.319099.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37589138" target="_blank">37589138</a><a href="/pmc/articles/PMC10521789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35325455">Does platelet aggregation have any importance in fetal growth restriction pregnancies?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Misan N,
|
||
Burchardt B,
|
||
Korszun P,
|
||
Kapska K,
|
||
Kapska J,
|
||
Kawka-Paciorkowska K,
|
||
Ropacka-Lesiak M</span><br />
|
||
<span class="medgenPMjournal">Ginekol Pol</span>
|
||
2022;93(12):968-974.
|
||
Epub 2022 Mar 24
|
||
doi: 10.5603/GP.a2022.0006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35325455" target="_blank">35325455</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33062144">Increased Intraplatelet ADMA Level May Promote Platelet Activation in Diabetes Mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gawryś J,
|
||
Wiśniewski J,
|
||
Szahidewicz-Krupska E,
|
||
Gajecki D,
|
||
Leśniewska J,
|
||
Majda F,
|
||
Gawryś K,
|
||
Fortuna P,
|
||
Mlynarz P,
|
||
Doroszko A</span><br />
|
||
<span class="medgenPMjournal">Oxid Med Cell Longev</span>
|
||
2020;2020:6938629.
|
||
Epub 2020 Sep 29
|
||
doi: 10.1155/2020/6938629.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33062144" target="_blank">33062144</a><a href="/pmc/articles/PMC7542534" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25975006">Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wand S,
|
||
Schneider S,
|
||
Meybohm P,
|
||
Zacharowski K,
|
||
Weber CF</span><br />
|
||
<span class="medgenPMjournal">Clin Lab</span>
|
||
2015;61(3-4):379-87.
|
||
doi: 10.7754/clin.lab.2014.140931.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25975006" target="_blank">25975006</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20ADP-induced%20platelet%20aggregation%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37589138">Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brambilla M,
|
||
Becchetti A,
|
||
Rovati GE,
|
||
Cosentino N,
|
||
Conti M,
|
||
Canzano P,
|
||
Giesen PLA,
|
||
Loffreda A,
|
||
Bonomi A,
|
||
Cattaneo M,
|
||
De Candia E,
|
||
Podda GM,
|
||
Trabattoni D,
|
||
Werba PJ,
|
||
Campodonico J,
|
||
Pinna C,
|
||
Marenzi G,
|
||
Tremoli E,
|
||
Camera M</span><br />
|
||
<span class="medgenPMjournal">Arterioscler Thromb Vasc Biol</span>
|
||
2023 Oct;43(10):2042-2057.
|
||
Epub 2023 Aug 17
|
||
doi: 10.1161/ATVBAHA.123.319099.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37589138" target="_blank">37589138</a><a href="/pmc/articles/PMC10521789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34415054">Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang LP,
|
||
Ji JZ,
|
||
Ge PX,
|
||
Zhu T,
|
||
Mi QY,
|
||
Tai T,
|
||
Li YF,
|
||
Xie HG</span><br />
|
||
<span class="medgenPMjournal">Br J Pharmacol</span>
|
||
2022 Jan;179(1):46-64.
|
||
Epub 2021 Oct 29
|
||
doi: 10.1111/bph.15667.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34415054" target="_blank">34415054</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29577968">Glucocorticoids impair platelet thromboxane biosynthesis in community-acquired pneumonia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cangemi R,
|
||
Carnevale R,
|
||
Nocella C,
|
||
Calvieri C,
|
||
Cammisotto V,
|
||
Novo M,
|
||
Castellani V,
|
||
D'Amico A,
|
||
Zerbinati C,
|
||
Stefanini L,
|
||
Violi F;
|
||
SIXTUS Study Group</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Res</span>
|
||
2018 May;131:66-74.
|
||
Epub 2018 Mar 22
|
||
doi: 10.1016/j.phrs.2018.03.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29577968" target="_blank">29577968</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25291943">Detection of clopidogrel resistance using ADP induced aggregometry with specific inhibitor PGE1.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Slavik L,
|
||
Ulehlova J,
|
||
Krcova V,
|
||
Hlusi A,
|
||
Indrakova J,
|
||
Hutyra M,
|
||
Galuszka J,
|
||
Indrak K</span><br />
|
||
<span class="medgenPMjournal">Clin Lab</span>
|
||
2014;60(9):1475-80.
|
||
doi: 10.7754/clin.lab.2013.131004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25291943" target="_blank">25291943</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22791802">Effect of the carrier solution for hydroxyethyl starch on platelet aggregation and clot formation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schaden E,
|
||
Wetzel L,
|
||
Kozek-Langenecker S,
|
||
Thaler U,
|
||
Scharbert G</span><br />
|
||
<span class="medgenPMjournal">Br J Anaesth</span>
|
||
2012 Oct;109(4):572-7.
|
||
Epub 2012 Jul 11
|
||
doi: 10.1093/bja/aes229.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22791802" target="_blank">22791802</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20ADP-induced%20platelet%20aggregation%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (46)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38721951">The prognostic value of platelet aggregation in patients with sepsis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen T,
|
||
Yang H,
|
||
Zhao Z,
|
||
Wang H,
|
||
Zhong S</span><br />
|
||
<span class="medgenPMjournal">Allergol Immunopathol (Madr)</span>
|
||
2024;52(3):17-21.
|
||
Epub 2024 May 1
|
||
doi: 10.15586/aei.v52i3.1039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38721951" target="_blank">38721951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36825598">The evolving knowledge on primary hemostasis in patients with cirrhosis: A comprehensive review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zanetto A,
|
||
Campello E,
|
||
Senzolo M,
|
||
Simioni P</span><br />
|
||
<span class="medgenPMjournal">Hepatology</span>
|
||
2024 Feb 1;79(2):460-481.
|
||
Epub 2023 Feb 27
|
||
doi: 10.1097/HEP.0000000000000349.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36825598" target="_blank">36825598</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34415054">Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang LP,
|
||
Ji JZ,
|
||
Ge PX,
|
||
Zhu T,
|
||
Mi QY,
|
||
Tai T,
|
||
Li YF,
|
||
Xie HG</span><br />
|
||
<span class="medgenPMjournal">Br J Pharmacol</span>
|
||
2022 Jan;179(1):46-64.
|
||
Epub 2021 Oct 29
|
||
doi: 10.1111/bph.15667.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34415054" target="_blank">34415054</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29577968">Glucocorticoids impair platelet thromboxane biosynthesis in community-acquired pneumonia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cangemi R,
|
||
Carnevale R,
|
||
Nocella C,
|
||
Calvieri C,
|
||
Cammisotto V,
|
||
Novo M,
|
||
Castellani V,
|
||
D'Amico A,
|
||
Zerbinati C,
|
||
Stefanini L,
|
||
Violi F;
|
||
SIXTUS Study Group</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Res</span>
|
||
2018 May;131:66-74.
|
||
Epub 2018 Mar 22
|
||
doi: 10.1016/j.phrs.2018.03.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29577968" target="_blank">29577968</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25975006">Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wand S,
|
||
Schneider S,
|
||
Meybohm P,
|
||
Zacharowski K,
|
||
Weber CF</span><br />
|
||
<span class="medgenPMjournal">Clin Lab</span>
|
||
2015;61(3-4):379-87.
|
||
doi: 10.7754/clin.lab.2014.140931.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25975006" target="_blank">25975006</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20ADP-induced%20platelet%20aggregation%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38721951">The prognostic value of platelet aggregation in patients with sepsis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen T,
|
||
Yang H,
|
||
Zhao Z,
|
||
Wang H,
|
||
Zhong S</span><br />
|
||
<span class="medgenPMjournal">Allergol Immunopathol (Madr)</span>
|
||
2024;52(3):17-21.
|
||
Epub 2024 May 1
|
||
doi: 10.15586/aei.v52i3.1039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38721951" target="_blank">38721951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36825598">The evolving knowledge on primary hemostasis in patients with cirrhosis: A comprehensive review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zanetto A,
|
||
Campello E,
|
||
Senzolo M,
|
||
Simioni P</span><br />
|
||
<span class="medgenPMjournal">Hepatology</span>
|
||
2024 Feb 1;79(2):460-481.
|
||
Epub 2023 Feb 27
|
||
doi: 10.1097/HEP.0000000000000349.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36825598" target="_blank">36825598</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34415054">Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang LP,
|
||
Ji JZ,
|
||
Ge PX,
|
||
Zhu T,
|
||
Mi QY,
|
||
Tai T,
|
||
Li YF,
|
||
Xie HG</span><br />
|
||
<span class="medgenPMjournal">Br J Pharmacol</span>
|
||
2022 Jan;179(1):46-64.
|
||
Epub 2021 Oct 29
|
||
doi: 10.1111/bph.15667.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34415054" target="_blank">34415054</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33062144">Increased Intraplatelet ADMA Level May Promote Platelet Activation in Diabetes Mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gawryś J,
|
||
Wiśniewski J,
|
||
Szahidewicz-Krupska E,
|
||
Gajecki D,
|
||
Leśniewska J,
|
||
Majda F,
|
||
Gawryś K,
|
||
Fortuna P,
|
||
Mlynarz P,
|
||
Doroszko A</span><br />
|
||
<span class="medgenPMjournal">Oxid Med Cell Longev</span>
|
||
2020;2020:6938629.
|
||
Epub 2020 Sep 29
|
||
doi: 10.1155/2020/6938629.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33062144" target="_blank">33062144</a><a href="/pmc/articles/PMC7542534" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29577968">Glucocorticoids impair platelet thromboxane biosynthesis in community-acquired pneumonia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cangemi R,
|
||
Carnevale R,
|
||
Nocella C,
|
||
Calvieri C,
|
||
Cammisotto V,
|
||
Novo M,
|
||
Castellani V,
|
||
D'Amico A,
|
||
Zerbinati C,
|
||
Stefanini L,
|
||
Violi F;
|
||
SIXTUS Study Group</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Res</span>
|
||
2018 May;131:66-74.
|
||
Epub 2018 Mar 22
|
||
doi: 10.1016/j.phrs.2018.03.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29577968" target="_blank">29577968</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20ADP-induced%20platelet%20aggregation%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (43)</a></div></div>
|
||
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4025282%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
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