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<!--
UID=868122
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-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Increased intervertebral space</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868122</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4022513</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030320">HP:0030320</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">An increase in the vertical distance between adjacent vertebral bodies, observed as an increase in the intervertebral disk space. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Increased intervertebral space</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1763488" ref="tree=MeSH" title="MedGen record for Abnormality of the musculoskeletal system">Abnormality of the musculoskeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/867418" ref="tree=MeSH" title="MedGen record for Abnormality of the skeletal system">Abnormality of the skeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/868760" ref="tree=MeSH" title="MedGen record for Abnormal skeletal morphology">Abnormal skeletal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892434" ref="tree=MeSH" title="MedGen record for Abnormal axial skeleton morphology">Abnormal axial skeleton morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892426" ref="tree=MeSH" title="MedGen record for Abnormality of the vertebral column">Abnormality of the vertebral column</a></span><ul><li><span class="TLline"><a href="/medgen/870792" ref="tree=MeSH" title="MedGen record for Abnormal intervertebral disk morphology">Abnormal intervertebral disk morphology</a></span><ul><li><span class="matched_ds">Increased intervertebral space</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_98150"><div><strong>Dysosteosclerosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98150</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0432262</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A rare genetic primary bone dysplasia disease characterized by progressive osteosclerosis and platyspondyly.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/98150">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_375009"><div><strong>Spondyloenchondrodysplasia with immune dysregulation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375009</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1842763</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Spondyloenchondrodysplasia with immune dysregulation (SPENCDI) is an immunoosseous dysplasia combining the typical metaphyseal and vertebral bone lesions of spondyloenchondrodysplasia (SPENCD) with immune dysfunction and neurologic involvement. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. The vertebral bodies show dorsally accentuated platyspondyly with disturbance of ossification. Clinical abnormalities such as short stature, rhizomelic micromelia, increased lumbar lordosis, barrel chest, facial anomalies, and clumsy movements may be present (Menger et al., 1989). Central nervous system involvement includes spasticity, mental retardation, and cerebral calcifications, and immune dysregulation ranges from autoimmunity to immunodeficiency. Neurologic and autoimmune manifestations have been observed in different combinations within a single family, suggesting that this disorder may be defined by specific radiographic features but has remarkably pleiotropic manifestations (Renella et al., 2006). Briggs et al. (2016) also noted variability in skeletal, neurologic, and immune phenotypes, which was sometimes marked between members of the same family.&#13; Classification of the Enchondromatoses&#13; In their classification of the enchondromatoses, Spranger et al. (1978) called Ollier disease and Maffucci syndrome types I and II enchondromatosis, respectively; metachondromatosis (156250), type III; and spondyloenchondrodysplasia (SPENCD), also called spondyloenchondromatosis, type IV; enchondromatosis with irregular vertebral lesions, type V; and generalized enchondromatosis, type VI. Halal and Azouz (1991) added 3 tentative categories to the 6 in the classification of Spranger et al. (1978).&#13; Pansuriya et al. (2010) suggested a new classification of enchondromatosis (multiple enchondromas).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/375009">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_338072"><div><strong>Atelosteogenesis type II</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338072</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1850554</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Clinical features of SLC26A2-related atelosteogenesis include rhizomelic limb shortening with normal-sized skull, hitchhiker thumbs, small chest, protuberant abdomen, cleft palate, and distinctive facial features (midface retrusion, depressed nasal bridge, epicanthus, micrognathia). Other typical findings are ulnar deviation of the fingers, gap between the first and second toes, and clubfoot. SLC26A2-related atelosteogenesis is usually lethal at birth or shortly thereafter due to pulmonary hypoplasia and tracheobronchomalacia. However, it exists in a continuous phenotypic spectrum with SLC26A2-related diastrophic dysplasia, and long-term survivors have been reported.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/338072">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1381460"><div><strong>Immunoskeletal dysplasia with neurodevelopmental abnormalities</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1381460</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4479452</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1381460">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1714019"><div><strong>Spondylometaphyseal dysplasia with corneal dystrophy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1714019</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5394555</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Spondylometaphyseal dysplasia with corneal dystrophy (SMDCD) is characterized by short stature due to short proximal and distal long bones. Affected individuals also exhibit narrow thorax with pulmonary hypoplasia and respiratory failure, as well as corneal dystrophy. Severe developmental delay has been observed (Ben-Salem et al., 2018).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1714019">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1806238"><div><strong>Craniotubular dysplasia, Ikegawa type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1806238</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5575335</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Craniotubular dysplasia, Ikegawa type (CTDI) is characterized by childhood-onset short stature in association with macrocephaly, dolichocephaly, or prominent forehead. Radiography shows hyperostosis of the calvaria and skull base, with metadiaphyseal undermodeling of the long tubular bones and mild shortening and diaphyseal broadening of the short tubular bones. Affected individuals experience progressive vision loss in the first decade of life due to optic nerve compression, and deafness may develop in the second decade of life (Guo et al., 2021).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1806238">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338072" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atelosteogenesis type II</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1806238" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Craniotubular dysplasia, Ikegawa type</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_98150" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dysosteosclerosis</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1381460" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunoskeletal dysplasia with neurodevelopmental abnormalities</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_375009" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloenchondrodysplasia with immune dysregulation</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1714019" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondylometaphyseal dysplasia with corneal dystrophy</a></div></div>
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<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36814366">Presentation, Diagnosis, and Management of Lower Back Pain Associated with Spinal Stenosis: A Narrative Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sobański D,
Staszkiewicz R,
Stachura M,
Gadzieliński M,
Grabarek BO</span><br />
<span class="medgenPMjournal">Med Sci Monit</span>
2023 Feb 23;29:e939237.
doi: 10.12659/MSM.939237.
<span class="bold">PMID: </span><a href="/pubmed/36814366" target="_blank">36814366</a><a href="/pmc/articles/PMC9972697" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28719453">Reliability and Clinical Utility of the CARDS Classification for Degenerative Spondylolisthesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sobol GL,
Hilibrand A,
Davis A,
Millhouse P,
Koerner J,
Kepler C,
Schroeder GD,
Krystal JD,
Olsson EC,
Rihn J,
Anderson DG,
Vaccaro A,
Radcliff K</span><br />
<span class="medgenPMjournal">Clin Spine Surg</span>
2018 Feb;31(1):E69-E73.
doi: 10.1097/BSD.0000000000000571.
<span class="bold">PMID: </span><a href="/pubmed/28719453" target="_blank">28719453</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1533776">Epidemiology, etiology, diagnostic evaluation, and treatment of low back pain.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Borenstein D</span><br />
<span class="medgenPMjournal">Curr Opin Rheumatol</span>
1992 Apr;4(2):226-32.
doi: 10.1097/00002281-199204000-00016.
<span class="bold">PMID: </span><a href="/pubmed/1533776" target="_blank">1533776</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(increased%20intervertebral%20space)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (13)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/35238470">Not all pseudoaneurysms are femoral-A transcaval transcatheter aortic valve replacement rare complication.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mano TB,
Ramos R,
Cacela D,
Patrício L</span><br />
<span class="medgenPMjournal">Catheter Cardiovasc Interv</span>
2022 Apr;99(5):1696-1699.
Epub 2022 Mar 3
doi: 10.1002/ccd.30140.
<span class="bold">PMID: </span><a href="/pubmed/35238470" target="_blank">35238470</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33933696">Vertebral Pneumatocyst-A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Garg K,
Dash A,
Aggarwal A,
Duetzmann S</span><br />
<span class="medgenPMjournal">World Neurosurg</span>
2021 Jul;151:77-86.
Epub 2021 Apr 29
doi: 10.1016/j.wneu.2021.04.092.
<span class="bold">PMID: </span><a href="/pubmed/33933696" target="_blank">33933696</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24770556">Optimizing success with lumbar disc arthroplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gornet MF,
Schranck F,
Wharton ND,
Beall DP,
Jones E,
Myers ME,
Hipp JA</span><br />
<span class="medgenPMjournal">Eur Spine J</span>
2014 Oct;23(10):2127-35.
Epub 2014 Apr 26
doi: 10.1007/s00586-014-3309-8.
<span class="bold">PMID: </span><a href="/pubmed/24770556" target="_blank">24770556</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21574965">Neuraxial techniques in patients with pre-existing back impairment or prior spine interventions: a topical review with special reference to obstetrics.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vercauteren M,
Waets P,
Pitkänen M,
Förster J</span><br />
<span class="medgenPMjournal">Acta Anaesthesiol Scand</span>
2011 Sep;55(8):910-7.
Epub 2011 May 16
doi: 10.1111/j.1399-6576.2011.02443.x.
<span class="bold">PMID: </span><a href="/pubmed/21574965" target="_blank">21574965</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15310748">Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shen W,
Punyanitya M,
Wang Z,
Gallagher D,
St-Onge MP,
Albu J,
Heymsfield SB,
Heshka S</span><br />
<span class="medgenPMjournal">J Appl Physiol (1985)</span>
2004 Dec;97(6):2333-8.
Epub 2004 Aug 13
doi: 10.1152/japplphysiol.00744.2004.
<span class="bold">PMID: </span><a href="/pubmed/15310748" target="_blank">15310748</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20intervertebral%20space%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (402)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34855717">Gout Storm.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Martins D,
Tonon CR,
Pacca RL,
Matchil NL,
Junior LAJ,
Queiroz DS,
Pereira FWL,
Silva AM,
Padovese V,
Padovani de Toledo Moraes M,
Luiz da Silva D,
Cardoso Nóbrega V,
Curcelli EC,
Okoshi MP</span><br />
<span class="medgenPMjournal">Am J Case Rep</span>
2021 Sep 20;22:e932683.
doi: 10.12659/AJCR.932683.
<span class="bold">PMID: </span><a href="/pubmed/34855717" target="_blank">34855717</a><a href="/pmc/articles/PMC8475732" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32359347">Infected Schmorl's node: a case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kim HS,
Raorane HD,
Sharma SB,
Wu PH,
Jang IT</span><br />
<span class="medgenPMjournal">BMC Musculoskelet Disord</span>
2020 May 2;21(1):280.
doi: 10.1186/s12891-020-03276-4.
<span class="bold">PMID: </span><a href="/pubmed/32359347" target="_blank">32359347</a><a href="/pmc/articles/PMC7196219" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30407580">Neurosurgery and Manned Spaceflight.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Panesar SS,
Fernandez-Miranda JC,
Kliot M,
Ashkan K</span><br />
<span class="medgenPMjournal">Neurosurgery</span>
2020 Mar 1;86(3):317-324.
doi: 10.1093/neuros/nyy531.
<span class="bold">PMID: </span><a href="/pubmed/30407580" target="_blank">30407580</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24770556">Optimizing success with lumbar disc arthroplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gornet MF,
Schranck F,
Wharton ND,
Beall DP,
Jones E,
Myers ME,
Hipp JA</span><br />
<span class="medgenPMjournal">Eur Spine J</span>
2014 Oct;23(10):2127-35.
Epub 2014 Apr 26
doi: 10.1007/s00586-014-3309-8.
<span class="bold">PMID: </span><a href="/pubmed/24770556" target="_blank">24770556</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15310748">Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shen W,
Punyanitya M,
Wang Z,
Gallagher D,
St-Onge MP,
Albu J,
Heymsfield SB,
Heshka S</span><br />
<span class="medgenPMjournal">J Appl Physiol (1985)</span>
2004 Dec;97(6):2333-8.
Epub 2004 Aug 13
doi: 10.1152/japplphysiol.00744.2004.
<span class="bold">PMID: </span><a href="/pubmed/15310748" target="_blank">15310748</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20intervertebral%20space%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (167)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/34855717">Gout Storm.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Martins D,
Tonon CR,
Pacca RL,
Matchil NL,
Junior LAJ,
Queiroz DS,
Pereira FWL,
Silva AM,
Padovese V,
Padovani de Toledo Moraes M,
Luiz da Silva D,
Cardoso Nóbrega V,
Curcelli EC,
Okoshi MP</span><br />
<span class="medgenPMjournal">Am J Case Rep</span>
2021 Sep 20;22:e932683.
doi: 10.12659/AJCR.932683.
<span class="bold">PMID: </span><a href="/pubmed/34855717" target="_blank">34855717</a><a href="/pmc/articles/PMC8475732" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32359347">Infected Schmorl's node: a case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kim HS,
Raorane HD,
Sharma SB,
Wu PH,
Jang IT</span><br />
<span class="medgenPMjournal">BMC Musculoskelet Disord</span>
2020 May 2;21(1):280.
doi: 10.1186/s12891-020-03276-4.
<span class="bold">PMID: </span><a href="/pubmed/32359347" target="_blank">32359347</a><a href="/pmc/articles/PMC7196219" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30407580">Neurosurgery and Manned Spaceflight.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Panesar SS,
Fernandez-Miranda JC,
Kliot M,
Ashkan K</span><br />
<span class="medgenPMjournal">Neurosurgery</span>
2020 Mar 1;86(3):317-324.
doi: 10.1093/neuros/nyy531.
<span class="bold">PMID: </span><a href="/pubmed/30407580" target="_blank">30407580</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26321411">Spondylodiscitis following sacral colpopexy procedure: is it an infection or graft rejection?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Api M,
Kayatas S,
Boza A</span><br />
<span class="medgenPMjournal">Eur J Obstet Gynecol Reprod Biol</span>
2015 Nov;194:43-8.
Epub 2015 Aug 21
doi: 10.1016/j.ejogrb.2015.08.003.
<span class="bold">PMID: </span><a href="/pubmed/26321411" target="_blank">26321411</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24770556">Optimizing success with lumbar disc arthroplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gornet MF,
Schranck F,
Wharton ND,
Beall DP,
Jones E,
Myers ME,
Hipp JA</span><br />
<span class="medgenPMjournal">Eur Spine J</span>
2014 Oct;23(10):2127-35.
Epub 2014 Apr 26
doi: 10.1007/s00586-014-3309-8.
<span class="bold">PMID: </span><a href="/pubmed/24770556" target="_blank">24770556</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20intervertebral%20space%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (234)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/24896747">Traumatic myelopathy: current concepts in imaging.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">De Smet E,
Vanhoenacker FM,
Parizel PM</span><br />
<span class="medgenPMjournal">Semin Musculoskelet Radiol</span>
2014 Jul;18(3):318-31.
Epub 2014 Jun 4
doi: 10.1055/s-0034-1375573.
<span class="bold">PMID: </span><a href="/pubmed/24896747" target="_blank">24896747</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24770556">Optimizing success with lumbar disc arthroplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gornet MF,
Schranck F,
Wharton ND,
Beall DP,
Jones E,
Myers ME,
Hipp JA</span><br />
<span class="medgenPMjournal">Eur Spine J</span>
2014 Oct;23(10):2127-35.
Epub 2014 Apr 26
doi: 10.1007/s00586-014-3309-8.
<span class="bold">PMID: </span><a href="/pubmed/24770556" target="_blank">24770556</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15310748">Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shen W,
Punyanitya M,
Wang Z,
Gallagher D,
St-Onge MP,
Albu J,
Heymsfield SB,
Heshka S</span><br />
<span class="medgenPMjournal">J Appl Physiol (1985)</span>
2004 Dec;97(6):2333-8.
Epub 2004 Aug 13
doi: 10.1152/japplphysiol.00744.2004.
<span class="bold">PMID: </span><a href="/pubmed/15310748" target="_blank">15310748</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12766685">Impact of somatosensory evoked potential monitoring on cervical surgery.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kombos T,
Suess O,
Da Silva C,
Ciklatekerlio O,
Nobis V,
Brock M</span><br />
<span class="medgenPMjournal">J Clin Neurophysiol</span>
2003 Apr;20(2):122-8.
doi: 10.1097/00004691-200304000-00006.
<span class="bold">PMID: </span><a href="/pubmed/12766685" target="_blank">12766685</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2138335">The relief of low back pain with the WARP abdominoplasty: a preliminary report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Toranto IR</span><br />
<span class="medgenPMjournal">Plast Reconstr Surg</span>
1990 Apr;85(4):545-55.
doi: 10.1097/00006534-199004000-00009.
<span class="bold">PMID: </span><a href="/pubmed/2138335" target="_blank">2138335</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20intervertebral%20space%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (171)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/27147527">Vacuum phenomenon.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yanagawa Y,
Ohsaka H,
Jitsuiki K,
Yoshizawa T,
Takeuchi I,
Omori K,
Oode Y,
Ishikawa K</span><br />
<span class="medgenPMjournal">Emerg Radiol</span>
2016 Aug;23(4):377-82.
Epub 2016 May 4
doi: 10.1007/s10140-016-1401-6.
<span class="bold">PMID: </span><a href="/pubmed/27147527" target="_blank">27147527</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26321411">Spondylodiscitis following sacral colpopexy procedure: is it an infection or graft rejection?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Api M,
Kayatas S,
Boza A</span><br />
<span class="medgenPMjournal">Eur J Obstet Gynecol Reprod Biol</span>
2015 Nov;194:43-8.
Epub 2015 Aug 21
doi: 10.1016/j.ejogrb.2015.08.003.
<span class="bold">PMID: </span><a href="/pubmed/26321411" target="_blank">26321411</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24482074">Ageing and degenerative changes of the intervertebral disc and their impact on spinal flexibility.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Galbusera F,
van Rijsbergen M,
Ito K,
Huyghe JM,
Brayda-Bruno M,
Wilke HJ</span><br />
<span class="medgenPMjournal">Eur Spine J</span>
2014 Jun;23 Suppl 3:S324-32.
Epub 2014 Jan 31
doi: 10.1007/s00586-014-3203-4.
<span class="bold">PMID: </span><a href="/pubmed/24482074" target="_blank">24482074</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15310748">Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shen W,
Punyanitya M,
Wang Z,
Gallagher D,
St-Onge MP,
Albu J,
Heymsfield SB,
Heshka S</span><br />
<span class="medgenPMjournal">J Appl Physiol (1985)</span>
2004 Dec;97(6):2333-8.
Epub 2004 Aug 13
doi: 10.1152/japplphysiol.00744.2004.
<span class="bold">PMID: </span><a href="/pubmed/15310748" target="_blank">15310748</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2594206">Prophylaxis of postoperative lumbar spondylodiscitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zink PM,
Frank AM,
Trappe AE</span><br />
<span class="medgenPMjournal">Neurosurg Rev</span>
1989;12(4):297-303.
doi: 10.1007/BF01780844.
<span class="bold">PMID: </span><a href="/pubmed/2594206" target="_blank">2594206</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20intervertebral%20space%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (291)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/35259500">Systematic Review: Applications of Intraoperative Ultrasonography in Spinal Surgery.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Patel MR,
Jacob KC,
Parsons AW,
Chavez FA,
Ribot MA,
Munim MA,
Vanjani NN,
Pawlowski H,
Prabhu MC,
Singh K</span><br />
<span class="medgenPMjournal">World Neurosurg</span>
2022 Aug;164:e45-e58.
Epub 2022 Mar 6
doi: 10.1016/j.wneu.2022.02.130.
<span class="bold">PMID: </span><a href="/pubmed/35259500" target="_blank">35259500</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33933696">Vertebral Pneumatocyst-A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Garg K,
Dash A,
Aggarwal A,
Duetzmann S</span><br />
<span class="medgenPMjournal">World Neurosurg</span>
2021 Jul;151:77-86.
Epub 2021 Apr 29
doi: 10.1016/j.wneu.2021.04.092.
<span class="bold">PMID: </span><a href="/pubmed/33933696" target="_blank">33933696</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28502688">Evaluating Outcomes of Stand-Alone Anterior Lumbar Interbody Fusion: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Giang G,
Mobbs R,
Phan S,
Tran TM,
Phan K</span><br />
<span class="medgenPMjournal">World Neurosurg</span>
2017 Aug;104:259-271.
Epub 2017 May 11
doi: 10.1016/j.wneu.2017.05.011.
<span class="bold">PMID: </span><a href="/pubmed/28502688" target="_blank">28502688</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25493689">Lumbar Neuraxial Ultrasound for Spinal and Epidural Anesthesia: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Perlas A,
Chaparro LE,
Chin KJ</span><br />
<span class="medgenPMjournal">Reg Anesth Pain Med</span>
2016 Mar-Apr;41(2):251-60.
doi: 10.1097/AAP.0000000000000184.
<span class="bold">PMID: </span><a href="/pubmed/25493689" target="_blank">25493689</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25183219">Is sequestrectomy a viable alternative to microdiscectomy? A systematic review of the literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fakouri B,
Shetty NR,
White TC</span><br />
<span class="medgenPMjournal">Clin Orthop Relat Res</span>
2015 Jun;473(6):1957-62.
doi: 10.1007/s11999-014-3904-3.
<span class="bold">PMID: </span><a href="/pubmed/25183219" target="_blank">25183219</a><a href="/pmc/articles/PMC4418979" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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