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<!--
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||
UID=766
|
||
ConceptID=C0007134
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Renal cell carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0007134</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Adenocarcinoma Of Kidney; Adenocarcinoma Of Kidneys; Adenocarcinoma, Renal; Adenocarcinoma, Renal Cell; Adenocarcinomas, Renal Cell; Cancer, Renal Cell; Carcinoma, Nephroid; Carcinoma, Renal; Carcinoma, Renal Cell; Carcinomas, Renal Cell; Kidney, Adenocarcinoma Of; Nephroid Carcinoma; Nephroid Carcinomas; Renal Adenocarcinoma; Renal Adenocarcinomas; Renal Carcinoma; Renal Carcinomas; Renal Cell Adenocarcinoma; Renal Cell Adenocarcinomas; Renal Cell Cancer; Renal Cell Cancers; Renal Cell Carcinoma; Renal Cell Carcinomas</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Renal cell carcinoma - morphology (41607009); Renal cell carcinoma (702391001); Hypernephroma (702391001); Renal cell carcinoma (41607009); Renal cell adenocarcinoma (41607009)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005584">HP:0005584</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005086" target="_blank">MONDO:0005086</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/144700" target="_blank">144700</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=217071">ORPHA217071</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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|
||
<div class="portlet mgSection" id="ID_118">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007134[DISCUI]&test_type=Clinical" ref="ncbi_uid=766">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0007134[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=766">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=766" target="_blank" href="/omim/144700">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=766" ref="ncbi_uid=766">V</a></span></span><span class="TLline">Renal cell carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/122" ref="tree=MeSH" title="MedGen record for Adenocarcinoma">Adenocarcinoma</a></span><ul><li><span class="matched_ds">Renal cell carcinoma</span><ul><li><span class="TLline"><a href="/medgen/1644241" ref="tree=MeSH" title="MedGen record for Acquired cystic disease-associated renal cell carcinoma">Acquired cystic disease-associated renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1661651" ref="tree=MeSH" title="MedGen record for Bilateral Synchronous Sporadic Renal Cell Carcinoma">Bilateral Synchronous Sporadic Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232070" ref="tree=MeSH" title="MedGen record for Childhood kidney cell carcinoma">Childhood kidney cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/266091" ref="tree=MeSH" title="MedGen record for Chromophobe renal cell carcinoma">Chromophobe renal cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1653315" ref="tree=MeSH" title="MedGen record for Chromophobe Renal Cell Carcinoma Associated with Birt-Hogg-Dube Syndrome">Chromophobe Renal Cell Carcinoma Associated with Birt-Hogg-Dube Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/232080" ref="tree=MeSH" title="MedGen record for Classic variant of chromophobe renal cell carcinoma">Classic variant of chromophobe renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232458" ref="tree=MeSH" title="MedGen record for Eosinophilic variant of chromophobe renal cell carcinoma">Eosinophilic variant of chromophobe renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1766816" ref="tree=MeSH" title="MedGen record for Metastatic Chromophobe Renal Cell Carcinoma">Metastatic Chromophobe Renal Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1760698" ref="tree=MeSH" title="MedGen record for Advanced Chromophobe Renal Cell Carcinoma">Advanced Chromophobe Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1792304" ref="tree=MeSH" title="MedGen record for Locally Advanced Chromophobe Renal Cell Carcinoma">Locally Advanced Chromophobe Renal Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1667172" ref="tree=MeSH" title="MedGen record for Recurrent Chromophobe Renal Cell Carcinoma">Recurrent Chromophobe Renal Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/76018" ref="tree=MeSH" title="MedGen record for Clear cell carcinoma of kidney">Clear cell carcinoma of kidney</a></span><ul><li><span class="TLline"><a href="/medgen/1675671" ref="tree=MeSH" title="MedGen record for BAP1-Mutant Clear Cell Renal Cell Carcinoma">BAP1-Mutant Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1388623" ref="tree=MeSH" title="MedGen record for Clear cell papillary renal cell carcinoma">Clear cell papillary renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232245" ref="tree=MeSH" title="MedGen record for Grade 1 Clear Cell Renal Cell Carcinoma">Grade 1 Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232560" ref="tree=MeSH" title="MedGen record for Grade 2 Clear Cell Renal Cell Carcinoma">Grade 2 Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232248" ref="tree=MeSH" title="MedGen record for Grade 3 Clear Cell Renal Cell Carcinoma">Grade 3 Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272679" ref="tree=MeSH" title="MedGen record for Grade 4 Clear Cell Renal Cell Carcinoma">Grade 4 Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234343" ref="tree=MeSH" title="MedGen record for Hereditary clear cell renal cell carcinoma">Hereditary clear cell renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/419920" ref="tree=MeSH" title="MedGen record for Metastatic Clear Cell Renal Cell Carcinoma">Metastatic Clear Cell Renal Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1688790" ref="tree=MeSH" title="MedGen record for Advanced Clear Cell Renal Cell Carcinoma">Advanced Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1751253" ref="tree=MeSH" title="MedGen record for Locally Advanced Clear Cell Renal Cell Carcinoma">Locally Advanced Clear Cell Renal Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/87547" ref="tree=MeSH" title="MedGen record for Multilocular clear cell renal cell carcinoma">Multilocular clear cell renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/235372" ref="tree=MeSH" title="MedGen record for Non-Hereditary Clear Cell Renal Cell Carcinoma">Non-Hereditary Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1650549" ref="tree=MeSH" title="MedGen record for Recurrent Clear Cell Renal Cell Carcinoma">Recurrent Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1715804" ref="tree=MeSH" title="MedGen record for Refractory Clear Cell Renal Cell Carcinoma">Refractory Clear Cell Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1710342" ref="tree=MeSH" title="MedGen record for Unresectable Clear Cell Renal Cell Carcinoma">Unresectable Clear Cell Renal Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/266092" ref="tree=MeSH" title="MedGen record for Collecting duct carcinoma">Collecting duct carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1712739" ref="tree=MeSH" title="MedGen record for Fumarate Hydratase-Deficient Renal Cell Carcinoma">Fumarate Hydratase-Deficient Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/392857" ref="tree=MeSH" title="MedGen record for Hereditary renal cell carcinoma">Hereditary renal cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/353771" ref="tree=MeSH" title="MedGen record for Hereditary leiomyomatosis and renal cell cancer">Hereditary leiomyomatosis and renal cell cancer</a></span></li><li><span class="TLline"><a href="/medgen/163907" ref="tree=MeSH" title="MedGen record for Hereditary papillary renal cell carcinoma">Hereditary papillary renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/271100" ref="tree=MeSH" title="MedGen record for Renal Cell Carcinoma with Constitutional Chromosome 3 Translocations">Renal Cell Carcinoma with Constitutional Chromosome 3 Translocations</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/888108" ref="tree=MeSH" title="MedGen record for Kidney medullary carcinoma">Kidney medullary carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1677812" ref="tree=MeSH" title="MedGen record for Metastatic Kidney Medullary Carcinoma">Metastatic Kidney Medullary Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1724731" ref="tree=MeSH" title="MedGen record for Advanced Kidney Medullary Carcinoma">Advanced Kidney Medullary Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1688656" ref="tree=MeSH" title="MedGen record for Recurrent Kidney Medullary Carcinoma">Recurrent Kidney Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1695151" ref="tree=MeSH" title="MedGen record for Refractory Kidney Medullary Carcinoma">Refractory Kidney Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1767386" ref="tree=MeSH" title="MedGen record for Unresectable Kidney Medullary Carcinoma">Unresectable Kidney Medullary Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1661275" ref="tree=MeSH" title="MedGen record for Metastatic Renal Cell Carcinoma">Metastatic Renal Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1651550" ref="tree=MeSH" title="MedGen record for Advanced Renal Cell Carcinoma">Advanced Renal Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1704723" ref="tree=MeSH" title="MedGen record for Advanced Papillary Renal Cell Carcinoma">Advanced Papillary Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1765814" ref="tree=MeSH" title="MedGen record for Advanced Renal Cell Carcinoma, Not Otherwise Specified">Advanced Renal Cell Carcinoma, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1735882" ref="tree=MeSH" title="MedGen record for Advanced Sarcomatoid Renal Cell Carcinoma">Advanced Sarcomatoid Renal Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1717857" ref="tree=MeSH" title="MedGen record for Locally Advanced Renal Cell Carcinoma">Locally Advanced Renal Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1770105" ref="tree=MeSH" title="MedGen record for Locally Advanced Papillary Renal Cell Carcinoma">Locally Advanced Papillary Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1737513" ref="tree=MeSH" title="MedGen record for Locally Advanced Renal Cell Carcinoma, Not Otherwise Specified">Locally Advanced Renal Cell Carcinoma, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1772993" ref="tree=MeSH" title="MedGen record for Locally Advanced Sarcomatoid Renal Cell Carcinoma">Locally Advanced Sarcomatoid Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1650694" ref="tree=MeSH" title="MedGen record for Locally Advanced Unresectable Renal Cell Carcinoma">Locally Advanced Unresectable Renal Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1696629" ref="tree=MeSH" title="MedGen record for Metastatic Papillary Renal Cell Carcinoma">Metastatic Papillary Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1744916" ref="tree=MeSH" title="MedGen record for Metastatic Renal Cell Carcinoma, Not Otherwise Specified">Metastatic Renal Cell Carcinoma, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1678535" ref="tree=MeSH" title="MedGen record for Metastatic Sarcomatoid Renal Cell Carcinoma">Metastatic Sarcomatoid Renal Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1376834" ref="tree=MeSH" title="MedGen record for MIT family translocation renal cell carcinoma">MIT family translocation renal cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/235005" ref="tree=MeSH" title="MedGen record for Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions">Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions</a></span><ul><li><span class="TLline"><a href="/medgen/271101" ref="tree=MeSH" title="MedGen record for Renal Cell Carcinoma Associated with inv(X)(p11;q12)">Renal Cell Carcinoma Associated with inv(X)(p11;q12)</a></span></li><li><span class="TLline"><a href="/medgen/271102" ref="tree=MeSH" title="MedGen record for Renal Cell Carcinoma Associated with t(X;1)(p11.2;p34)">Renal Cell Carcinoma Associated with t(X;1)(p11.2;p34)</a></span></li><li><span class="TLline"><a href="/medgen/271477" ref="tree=MeSH" title="MedGen record for Renal Cell Carcinoma Associated with t(X;1)(p11.2;q21)">Renal Cell Carcinoma Associated with t(X;1)(p11.2;q21)</a></span></li><li><span class="TLline"><a href="/medgen/271476" ref="tree=MeSH" title="MedGen record for Renal Cell Carcinoma Associated with t(X;17)(p11.2;q25)">Renal Cell Carcinoma Associated with t(X;17)(p11.2;q25)</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1664261" ref="tree=MeSH" title="MedGen record for TFEB-rearranged renal cell carcinoma">TFEB-rearranged renal cell carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1640204" ref="tree=MeSH" title="MedGen record for Mucinous tubular and spindle renal cell carcinoma">Mucinous tubular and spindle renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/266300" ref="tree=MeSH" title="MedGen record for Papillary renal cell carcinoma">Papillary renal cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/237026" ref="tree=MeSH" title="MedGen record for Papillary renal cell carcinoma type 1">Papillary renal cell carcinoma type 1</a></span></li><li><span class="TLline"><a href="/medgen/277837" ref="tree=MeSH" title="MedGen record for Papillary renal cell carcinoma type 2">Papillary renal cell carcinoma type 2</a></span></li><li><span class="TLline"><a href="/medgen/277666" ref="tree=MeSH" title="MedGen record for Papillary renal cell carcinoma, sporadic">Papillary renal cell carcinoma, sporadic</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/82958" ref="tree=MeSH" title="MedGen record for Recurrent Renal Cell Carcinoma">Recurrent Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1714249" ref="tree=MeSH" title="MedGen record for Refractory Renal Cell Carcinoma">Refractory Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/455796" ref="tree=MeSH" title="MedGen record for Renal Cell Cancer by AJCC v6 Stage">Renal Cell Cancer by AJCC v6 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/124492" ref="tree=MeSH" title="MedGen record for Stage I Renal Cell Cancer AJCC v6 and v7">Stage I Renal Cell Cancer AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/75851" ref="tree=MeSH" title="MedGen record for Stage II Renal Cell Cancer AJCC v6">Stage II Renal Cell Cancer AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/82957" ref="tree=MeSH" title="MedGen record for Stage III Renal Cell Cancer AJCC v6">Stage III Renal Cell Cancer AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/167834" ref="tree=MeSH" title="MedGen record for Stage IV Renal Cell Cancer AJCC v6">Stage IV Renal Cell Cancer AJCC v6</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/456294" ref="tree=MeSH" title="MedGen record for Renal Cell Cancer by AJCC v7 Stage">Renal Cell Cancer by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/459975" ref="tree=MeSH" title="MedGen record for Stage II Renal Cell Cancer AJCC v7">Stage II Renal Cell Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/459976" ref="tree=MeSH" title="MedGen record for Stage III Renal Cell Cancer AJCC v7">Stage III Renal Cell Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/459977" ref="tree=MeSH" title="MedGen record for Stage IV Renal Cell Cancer AJCC v7">Stage IV Renal Cell Cancer AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1631350" ref="tree=MeSH" title="MedGen record for Renal Cell Cancer by AJCC v8 Stage">Renal Cell Cancer by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1635804" ref="tree=MeSH" title="MedGen record for Stage I Renal Cell Cancer AJCC v8">Stage I Renal Cell Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1644054" ref="tree=MeSH" title="MedGen record for Stage II Renal Cell Cancer AJCC v8">Stage II Renal Cell Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1638343" ref="tree=MeSH" title="MedGen record for Stage III Renal Cell Cancer AJCC v8">Stage III Renal Cell Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1637620" ref="tree=MeSH" title="MedGen record for Stage IV Renal Cell Cancer AJCC v8">Stage IV Renal Cell Cancer AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/473928" ref="tree=MeSH" title="MedGen record for Renal cell carcinoma associated with neuroblastoma">Renal cell carcinoma associated with neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1658628" ref="tree=MeSH" title="MedGen record for Resectable Renal Cell Carcinoma">Resectable Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/220411" ref="tree=MeSH" title="MedGen record for Sarcomatoid renal cell carcinoma">Sarcomatoid renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1662930" ref="tree=MeSH" title="MedGen record for Succinate Dehydrogenase-Deficient Renal Cell Carcinoma">Succinate Dehydrogenase-Deficient Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/237021" ref="tree=MeSH" title="MedGen record for Transplant-Related Renal Cell Carcinoma">Transplant-Related Renal Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/925623" ref="tree=MeSH" title="MedGen record for Tubulocystic renal cell carcinoma">Tubulocystic renal cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1648539" ref="tree=MeSH" title="MedGen record for Unresectable Renal Cell Carcinoma">Unresectable Renal Cell Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=18821&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Renal cell carcinoma</span> in Orphanet.</div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="divPopper rprt" id="rdis_42458"><div><strong>Von Hippel-Lindau syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>42458</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0019562</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Von Hippel-Lindau syndrome (VHL) is characterized by hemangioblastomas of the brain, spinal cord, and retina; renal cysts and clear cell renal cell carcinoma; pheochromocytoma and paraganglioma; pancreatic cysts and neuroendocrine tumors; endolymphatic sac tumors; and epididymal and broad ligament cystadenomas. Retinal hemangioblastomas may be the initial manifestation of VHL and can cause vision loss. Cerebellar hemangioblastomas may be associated with headache, vomiting, gait disturbances, or ataxia. Spinal hemangioblastomas and related syrinx usually present with pain. Sensory and motor loss may develop with cord compression. Renal cell carcinoma occurs in about 70% of individuals with VHL and is the leading cause of mortality. Pheochromocytomas can be asymptomatic but may cause sustained or episodic hypertension. Pancreatic lesions often remain asymptomatic and rarely cause endocrine or exocrine insufficiency. Endolymphatic sac tumors can cause hearing loss of varying severity, which can be a presenting symptom. Cystadenomas of the epididymis are relatively common. They rarely cause problems, unless bilateral, in which case they may result in infertility.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/42458">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_83428"><div><strong>Colorectal cancer</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83428</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0346629</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/83428">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_353771"><div><strong>Hereditary leiomyomatosis and renal cell cancer</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>353771</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1708350</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">FH tumor predisposition syndrome is characterized by cutaneous leiomyomata, uterine leiomyomata (fibroids), and/or renal tumors. Pheochromocytoma and paraganglioma have also been described in a small number of families. Cutaneous leiomyomata appear as skin-colored to light brown papules or nodules distributed over the trunk and extremities, and occasionally on the face, and appear at a mean age of 30 years, increasing in size and number with age. Uterine leiomyomata tend to be numerous and large; age at diagnosis ranges from 18 to 53 years, with most women experiencing irregular or heavy menstruation and pelvic pain. Renal tumors are usually unilateral, solitary, and aggressive. They are associated with poor survival due to clinical aggressiveness and propensity to metastasize despite small primary tumor size. The median age of detection is approximately age 40 years.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/353771">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_344288"><div><strong>Tuberous sclerosis 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344288</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854465</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Tuberous sclerosis complex (TSC) involves abnormalities of the skin (hypomelanotic macules, confetti skin lesions, facial angiofibromas, shagreen patches, fibrous cephalic plaques, ungual fibromas); brain (subependymal nodules, cortical tubers, and subependymal giant cell astrocytomas [SEGAs], seizures, TSC-associated neuropsychiatric disorder [TAND]); kidneys (benign renal angiomyolipomas, epithelial cysts, oncocytoma, renal cell carcinoma); heart (rhabdomyomas, arrhythmias); and lungs (lymphangioleiomyomatosis [LAM], multifocal micronodular pneumonocyte hyperplasia). Central nervous system-related problems (including TAND) are the leading cause of morbidity, whereas kidney disease is the leading cause of mortality.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/344288">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_348170"><div><strong>Tuberous sclerosis 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>348170</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1860707</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Tuberous sclerosis complex (TSC) involves abnormalities of the skin (hypomelanotic macules, confetti skin lesions, facial angiofibromas, shagreen patches, fibrous cephalic plaques, ungual fibromas); brain (subependymal nodules, cortical tubers, and subependymal giant cell astrocytomas [SEGAs], seizures, TSC-associated neuropsychiatric disorder [TAND]); kidneys (benign renal angiomyolipomas, epithelial cysts, oncocytoma, renal cell carcinoma); heart (rhabdomyomas, arrhythmias); and lungs (lymphangioleiomyomatosis [LAM], multifocal micronodular pneumonocyte hyperplasia). Central nervous system-related problems (including TAND) are the leading cause of morbidity, whereas kidney disease is the leading cause of mortality.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/348170">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_349380"><div><strong>Paragangliomas 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349380</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1861848</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Hereditary paraganglioma-pheochromocytoma (PGL/PCC) syndromes are characterized by paragangliomas (tumors that arise from neuroendocrine tissues distributed along the paravertebral axis from the base of the skull to the pelvis) and pheochromocytomas (paragangliomas that are confined to the adrenal medulla). Sympathetic paragangliomas cause catecholamine excess; parasympathetic paragangliomas are most often nonsecretory. Extra-adrenal parasympathetic paragangliomas are located predominantly in the skull base and neck (referred to as head and neck paragangliomas [HNPGLs]) and sometimes in the upper mediastinum; approximately 95% of such tumors are nonsecretory. In contrast, extra-adrenal sympathetic paragangliomas are generally confined to the lower mediastinum, abdomen, and pelvis, and are typically secretory. Pheochromocytomas, which arise from the adrenal medulla, typically lead to catecholamine excess. Symptoms of PGL/PCCs result from either mass effects or catecholamine hypersecretion (e.g., sustained or paroxysmal elevations in blood pressure, headache, episodic profuse sweating, forceful palpitations, pallor, and apprehension or anxiety). The risk for developing metastatic disease is greater for extra-adrenal sympathetic paragangliomas than for pheochromocytomas. Additional tumors reported in individuals with hereditary PGL/PCC syndromes include gastrointestinal stromal tumors (GISTs), pulmonary chondromas, and clear cell renal cell carcinoma.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/349380">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_413407"><div><strong>NONPAPILLARY RENAL CARCINOMA 1 LOCUS</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>413407</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2750825</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/413407">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_477077"><div><strong>Renal cell carcinoma, Xp11-associated</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>477077</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3275446</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Xp11 translocation renal cell carcinomas (RCCX1) are a group of neoplasms distinguished by chromosomal translocations with breakpoints involving the TFE3 gene within tumor cells. The result is a TFE3 transcription factor gene fusion with 1 of multiple reported genes including ASPRCR1 (606236) on chromosome 17q25 and PRCC (179755) on 1q21, and more rarely, NONO (300084) on Xq13, SFPQ (605199) on 1p34, CLTC (118955) on 17q23, and unknown genes on chromosomes 3 and 10. Xp11 translocations are often found in pediatric tumors and less commonly in adults. However, adult cases may outnumber pediatric cases since renal cell carcinoma is more common in the adult population. Prior chemotherapy is a known risk factor for Xp11 translocations. Histology shows both clear cells and papillary architecture, often with abundant psammoma bodies, although variable histologic features have been observed (review by Ross and Argani, 2010). For a discussion of genetic heterogeneity of renal cell carcinoma, see RCC (144700).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/477077">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_482122"><div><strong>BAP1-related tumor predisposition syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482122</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for a specific skin lesion, BAP1-inactivated melanocytic tumors (BIMT; formerly called atypical Spitz tumors), and the following cancers, in descending order of frequency: uveal (eye) melanoma (UM), malignant mesothelioma (MMe), cutaneous melanoma (CM), renal cell carcinoma (RCC), basal cell carcinoma (BCC), meningioma, and cholangiocarcinoma. Onychopapillomas, hepatocellular carcinoma, and ovarian sex cord-stromal tumors may also be associated with BAP1-TPDS. Affected individuals can have more than one type of primary cancer. In general, the median age of onset of these tumors is younger than in the general population. UM tends to be a more aggressive class 2 tumor with higher risk for metastasis and reduced survival compared to UM occurring in the general population. RCC is usually of clear cell morphology, but other pathologies have been reported. MMe, especially pleural, has better survival and responds better to platinum chemotherapy than MMe not associated with a germline BAP1 pathogenic variant. The penetrance, natural history, life-time cancer risk for carriers, and frequencies of BAP1-associated tumors are yet to be fully determined.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/482122">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1051978"><div><strong>Birt-Hogg-Dube syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1051978</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN375946</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The clinical characteristics of Birt-Hogg-Dubé syndrome (BHDS) include cutaneous manifestations (fibrofolliculomas, acrochordons, angiofibromas, oral papules, cutaneous collagenomas, and epidermal cysts), pulmonary cysts / history of pneumothorax, renal cysts, and various types of renal tumors. Disease severity can vary significantly even within the same family. Skin lesions typically appear between the second and fourth decades of life and typically increase in size and number with age. Lung cysts are mainly in the basal lung regions; most individuals are asymptomatic but at high risk for spontaneous pneumothorax. Renal tumors can be bilateral and multifocal. The most common renal tumors are a hybrid of oncocytoma and chromophobe histologic cell types (oncocytic hybrid tumor); clear cell carcinoma and oncocytoma are also common.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1051978">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482122" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">BAP1-related tumor predisposition syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1051978" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Birt-Hogg-Dube syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_83428" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Colorectal cancer</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_353771" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary leiomyomatosis and renal cell cancer</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_413407" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">NONPAPILLARY RENAL CARCINOMA 1 LOCUS</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (10)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_349380" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Paragangliomas 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_477077" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Renal cell carcinoma, Xp11-associated</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344288" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tuberous sclerosis 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_348170" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tuberous sclerosis 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_42458" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Von Hippel-Lindau syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38788900">Renal cell carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Powles T,
|
||
Albiges L,
|
||
Bex A,
|
||
Comperat E,
|
||
Grünwald V,
|
||
Kanesvaran R,
|
||
Kitamura H,
|
||
McKay R,
|
||
Porta C,
|
||
Procopio G,
|
||
Schmidinger M,
|
||
Suarez C,
|
||
Teoh J,
|
||
de Velasco G,
|
||
Young M,
|
||
Gillessen S;
|
||
ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2024 Aug;35(8):692-706.
|
||
Epub 2024 May 22
|
||
doi: 10.1016/j.annonc.2024.05.537.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38788900" target="_blank">38788900</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38153686">Treatment Landscape of Renal Cell Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen YW,
|
||
Wang L,
|
||
Panian J,
|
||
Dhanji S,
|
||
Derweesh I,
|
||
Rose B,
|
||
Bagrodia A,
|
||
McKay RR</span><br />
|
||
<span class="medgenPMjournal">Curr Treat Options Oncol</span>
|
||
2023 Dec;24(12):1889-1916.
|
||
Epub 2023 Dec 28
|
||
doi: 10.1007/s11864-023-01161-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38153686" target="_blank">38153686</a><a href="/pmc/articles/PMC10781877" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35819037">Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bahadoram S,
|
||
Davoodi M,
|
||
Hassanzadeh S,
|
||
Bahadoram M,
|
||
Barahman M,
|
||
Mafakher L</span><br />
|
||
<span class="medgenPMjournal">G Ital Nefrol</span>
|
||
2022 Jun 20;39(3)
|
||
<span class="bold">PMID: </span><a href="/pubmed/35819037" target="_blank">35819037</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22renal%20cell%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2165)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37270385">Prognostic Models in Metastatic Renal Cell Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lemelin A,
|
||
Takemura K,
|
||
Heng DYC,
|
||
Ernst MS</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2023 Oct;37(5):925-935.
|
||
Epub 2023 Jun 1
|
||
doi: 10.1016/j.hoc.2023.04.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37270385" target="_blank">37270385</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37244822">Renal Cell Carcinoma of Variant Histology: Biology and Therapies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Msaouel P,
|
||
Genovese G,
|
||
Tannir NM</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2023 Oct;37(5):977-992.
|
||
Epub 2023 May 25
|
||
doi: 10.1016/j.hoc.2023.04.019.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37244822" target="_blank">37244822</a><a href="/pmc/articles/PMC11608423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35819037">Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bahadoram S,
|
||
Davoodi M,
|
||
Hassanzadeh S,
|
||
Bahadoram M,
|
||
Barahman M,
|
||
Mafakher L</span><br />
|
||
<span class="medgenPMjournal">G Ital Nefrol</span>
|
||
2022 Jun 20;39(3)
|
||
<span class="bold">PMID: </span><a href="/pubmed/35819037" target="_blank">35819037</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33753250">Comprehensive review of chromophobe renal cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garje R,
|
||
Elhag D,
|
||
Yasin HA,
|
||
Acharya L,
|
||
Vaena D,
|
||
Dahmoush L</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
2021 Apr;160:103287.
|
||
Epub 2021 Mar 19
|
||
doi: 10.1016/j.critrevonc.2021.103287.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33753250" target="_blank">33753250</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32869954">Pediatric and young adult renal cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ray S,
|
||
Jones R,
|
||
Pritchard-Jones K,
|
||
Dzhuma K,
|
||
van den Heuvel-Eibrink M,
|
||
Tytgat G,
|
||
van der Beek J,
|
||
Oades G,
|
||
Murphy D</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2020 Nov;67(11):e28675.
|
||
Epub 2020 Sep 1
|
||
doi: 10.1002/pbc.28675.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32869954" target="_blank">32869954</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Renal%20cell%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (16245)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37244822">Renal Cell Carcinoma of Variant Histology: Biology and Therapies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Msaouel P,
|
||
Genovese G,
|
||
Tannir NM</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2023 Oct;37(5):977-992.
|
||
Epub 2023 May 25
|
||
doi: 10.1016/j.hoc.2023.04.019.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37244822" target="_blank">37244822</a><a href="/pmc/articles/PMC11608423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34034966">Papillary renal cell carcinoma: Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mendhiratta N,
|
||
Muraki P,
|
||
Sisk AE Jr,
|
||
Shuch B</span><br />
|
||
<span class="medgenPMjournal">Urol Oncol</span>
|
||
2021 Jun;39(6):327-337.
|
||
Epub 2021 May 24
|
||
doi: 10.1016/j.urolonc.2021.04.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34034966" target="_blank">34034966</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33076665">Immunohistochemistry and renal neoplasias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pivovarčíková K,
|
||
Michalová K,
|
||
Hes O</span><br />
|
||
<span class="medgenPMjournal">Cesk Patol</span>
|
||
2020 Summer;56(3):130-139.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33076665" target="_blank">33076665</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29796844">Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Honda Y,
|
||
Nakamura Y,
|
||
Goto K,
|
||
Terada H,
|
||
Sentani K,
|
||
Yasui W,
|
||
Sekino Y,
|
||
Hayashi T,
|
||
Teishima J,
|
||
Matsubara A,
|
||
Akagi M,
|
||
Fuji T,
|
||
Baba Y,
|
||
Iida M,
|
||
Awai K</span><br />
|
||
<span class="medgenPMjournal">Abdom Radiol (NY)</span>
|
||
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<div class="nl"><a target="_blank" href="/pubmed/27279544">Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.</a></div>
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Escudier B,
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<div class="nl"><a target="_blank" href="/pubmed/17045087">Interleukin-2 therapy of metastatic renal cell carcinoma--predictors of response.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">McDermott DF,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Renal%20cell%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13611)</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/38181809">Stereotactic body radiotherapy for primary renal cell carcinoma: a systematic review and practice guideline from the International Society of Stereotactic Radiosurgery (ISRS).</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Siva S,
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Louie AV,
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Kotecha R,
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Barber MN,
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Ali M,
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Zhang Z,
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Guckenberger M,
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Kim MS,
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Scorsetti M,
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Tree AC,
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Slotman BJ,
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<span class="bold">PMID: </span><a href="/pubmed/38181809" target="_blank">38181809</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37146227">First-line therapy for adults with advanced renal cell carcinoma: a systematic review and network meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Aldin A,
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Besiroglu B,
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Adams A,
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Monsef I,
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Piechotta V,
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Tomlinson E,
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Hornbach C,
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Dressen N,
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Goldkuhle M,
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Maisch P,
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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<span class="bold">PMID: </span><a href="/pubmed/37146227" target="_blank">37146227</a><a href="/pmc/articles/PMC10158799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36100483">Epidemiology of Renal Cell Carcinoma: 2022 Update.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bukavina L,
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Bensalah K,
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Bray F,
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Carlo M,
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Challacombe B,
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Karam JA,
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<span class="medgenPMjournal">Eur Urol</span>
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2022 Nov;82(5):529-542.
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Epub 2022 Sep 10
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doi: 10.1016/j.eururo.2022.08.019.
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<span class="bold">PMID: </span><a href="/pubmed/36100483" target="_blank">36100483</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35728020">Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rathmell WK,
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Rumble RB,
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Van Veldhuizen PJ,
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Al-Ahmadie H,
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Emamekhoo H,
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Hauke RJ,
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Louie AV,
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Milowsky MI,
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Molina AM,
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Rose TL,
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Siva S,
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Zaorsky NG,
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Zhang T,
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Qamar R,
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Kungel TM,
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2022 Sep 1;40(25):2957-2995.
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Epub 2022 Jun 21
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doi: 10.1200/JCO.22.00868.
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<span class="bold">PMID: </span><a href="/pubmed/35728020" target="_blank">35728020</a></div>
|
||
|
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<div class="nl"><a target="_blank" href="/pubmed/27157369">Management of Renal Masses and Localized Renal Cancer: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pierorazio PM,
|
||
Johnson MH,
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Patel HD,
|
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Sozio SM,
|
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Sharma R,
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Iyoha E,
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Bass EB,
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Allaf ME</span><br />
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<span class="medgenPMjournal">J Urol</span>
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2016 Oct;196(4):989-99.
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Epub 2016 May 6
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doi: 10.1016/j.juro.2016.04.081.
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<span class="bold">PMID: </span><a href="/pubmed/27157369" target="_blank">27157369</a><a href="/pmc/articles/PMC5593254" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Renal%20cell%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (606)</a></div></div>
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||
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|
||
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|
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (13)</a></li>
|
||
<li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&test_type=Research" target="_blank">Research (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (15)</a></li>
|
||
<li><a href="/gtr/tests?term=C0007134%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0007134%5bDISCUI%5d" target="_blank">See all (20)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=217071" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Renal%20cell%20carcinoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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