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<!--
UID=472879
ConceptID=C0006664
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Calcinosis cutis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>472879</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0006664</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Calcification, Cutaneous; Calcinosis Cutis; Cutaneous Calcification; Cutaneous Calcifications</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Cutaneous calcification (21323007); Calcinosis cutis (21323007)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0025520">HP:0025520</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Deposition of calcium in the skin. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Calcinosis cutis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/1763488" ref="tree=MeSH" title="MedGen record for Abnormality of the musculoskeletal system">Abnormality of the musculoskeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/867418" ref="tree=MeSH" title="MedGen record for Abnormality of the skeletal system">Abnormality of the skeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/812556" ref="tree=MeSH" title="MedGen record for Ectopic calcification">Ectopic calcification</a></span><ul><li><span class="matched_ds">Calcinosis cutis</span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_75658"><div><strong>Primary hyperoxaluria, type I</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75658</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0268164</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Primary hyperoxaluria type 1 (PH1) is caused by deficiency of the liver peroxisomal enzyme alanine-glyoxylate aminotransferase (AGT), which catalyzes the conversion of glyoxylate to glycine. When AGT activity is reduced or absent, glyoxylate is converted to oxalate, which cannot be metabolized and must be excreted by the kidneys. Insoluble calcium oxalate crystals form due to high urinary oxalate concentration. Urinary crystals aggregate, leading to nephrolithiasis (i.e., calcium oxalate kidney stones) in the renal pelvis / urinary tract; often the crystals deposit in kidney parenchyma (nephrocalcinosis). The age at presentation of PH1 ranges from infancy (age &lt;12 months) in 10% of individuals, childhood/adolescence (age 1-17 years) in 70%, and adulthood (age =18 years) in 20%. The natural history of untreated PH1 is (1) progressive decline in kidney function due to complications of nephrolithiasis (e.g., urinary obstruction, infection) and nephrocalcinosis, and (2) in persons with advanced chronic kidney disease (CKD), high plasma oxalate concentrations result in other organ and tissue damage from calcium oxalate deposition (i.e., "oxalosis"), most commonly in the bones, heart, and retina. In the absence of treatment, progression of oxalosis results in death from kidney failure and/or other organ involvement.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/75658">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_450547"><div><strong>Reynolds syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>450547</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0748397</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An autoimmune disorder characterized by the association of primary biliary cirrhosis with limited cutaneous systemic sclerosis. Onset occurs between 30-65 years. Occurs sporadically, but rare familial cases with an unknown inheritance pattern have been observed. There is no cure and management is mainly supportive.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/450547">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_355311"><div><strong>Normophosphatemic familial tumoral calcinosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355311</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1864861</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove nowrap">See: <a href="/medgen/355311">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_816111"><div><strong>Hypopigmentation-punctate palmoplantar keratoderma syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816111</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3809781</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Cole disease (COLED) is a rare autosomal dominant disorder characterized by congenital or early-onset punctate keratoderma associated with irregularly shaped hypopigmented macules, which are typically found over the arms and legs but not the trunk or acral regions. Skin biopsies of palmoplantar lesions show nonspecific changes including hyperorthokeratosis, hypergranulosis, and acanthosis. Hypopigmented areas of skin, however, reveal a reduction in melanin content in keratinocytes but not in melanocytes, as well as hyperkeratosis and a normal number of melanocytes. Ultrastructurally, melanocytes show a disproportionately large number of melanosomes in the cytoplasm and dendrites, whereas keratinocytes show a paucity of these organelles, suggestive of impaired melanosome transfer (summary by Eytan et al., 2013). Some patients also exhibit calcinosis cutis or early-onset calcific tendinopathy (Eytan et al., 2013).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/816111">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816111" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypopigmentation-punctate palmoplantar keratoderma syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355311" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Normophosphatemic familial tumoral calcinosis</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75658" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary hyperoxaluria, type I</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_450547" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Reynolds syndrome</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/35569832">Management of Calcinosis Cutis in Rheumatic Diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Elahmar H,
Feldman BM,
Johnson SR</span><br />
<span class="medgenPMjournal">J Rheumatol</span>
2022 Sep;49(9):980-989.
Epub 2022 May 15
doi: 10.3899/jrheum.211393.
<span class="bold">PMID: </span><a href="/pubmed/35569832" target="_blank">35569832</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34537249">Topical sodium thiosulfate as treatment of calcinosis cutis: Case series and systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ricardo JW,
Sun HY,
Gorji M,
Sebaratnam DF</span><br />
<span class="medgenPMjournal">J Am Acad Dermatol</span>
2022 Aug;87(2):443-444.
Epub 2021 Sep 16
doi: 10.1016/j.jaad.2021.09.013.
<span class="bold">PMID: </span><a href="/pubmed/34537249" target="_blank">34537249</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31302187">Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: A review of the literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Traineau H,
Aggarwal R,
Monfort JB,
Senet P,
Oddis CV,
Chizzolini C,
Barbaud A,
Francès C,
Arnaud L,
Chasset F</span><br />
<span class="medgenPMjournal">J Am Acad Dermatol</span>
2020 Feb;82(2):317-325.
Epub 2019 Jul 11
doi: 10.1016/j.jaad.2019.07.006.
<span class="bold">PMID: </span><a href="/pubmed/31302187" target="_blank">31302187</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22calcinosis%20cutis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (22)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37261663">Intravenous Immunoglobulin in Idiopathic Inflammatory Myopathies: a Practical Guide for Clinical Use.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gandiga PC,
Ghetie D,
Anderson E,
Aggrawal R</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rep</span>
2023 Aug;25(8):152-168.
Epub 2023 Jun 1
doi: 10.1007/s11926-023-01105-w.
<span class="bold">PMID: </span><a href="/pubmed/37261663" target="_blank">37261663</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35397096">Clinical and ultrasonography follow-up of five cases of calcinosis cutis successfully treated with intralesional sodium thiosulfate.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tubau C,
Cubiró X,
Amat-Samaranch V,
Garcia-Melendo C,
Puig L,
Roé-Crespo E</span><br />
<span class="medgenPMjournal">J Ultrasound</span>
2022 Dec;25(4):995-1003.
Epub 2022 Apr 9
doi: 10.1007/s40477-022-00665-4.
<span class="bold">PMID: </span><a href="/pubmed/35397096" target="_blank">35397096</a><a href="/pmc/articles/PMC9705646" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21679811">Calcinosis cutis: part II. Treatment options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Reiter N,
El-Shabrawi L,
Leinweber B,
Berghold A,
Aberer E</span><br />
<span class="medgenPMjournal">J Am Acad Dermatol</span>
2011 Jul;65(1):15-22; quiz 23-4.
doi: 10.1016/j.jaad.2010.08.039.
<span class="bold">PMID: </span><a href="/pubmed/21679811" target="_blank">21679811</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19250446">Dermatologic conditions seen in end-stage renal disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cordova KB,
Oberg TJ,
Malik M,
Robinson-Bostom L</span><br />
<span class="medgenPMjournal">Semin Dial</span>
2009 Jan-Feb;22(1):45-55.
doi: 10.1111/j.1525-139X.2008.00534.x.
<span class="bold">PMID: </span><a href="/pubmed/19250446" target="_blank">19250446</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1918456">Skin and bones. I.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Orlow SJ,
Watsky KL,
Bolognia JL</span><br />
<span class="medgenPMjournal">J Am Acad Dermatol</span>
1991 Aug;25(2 Pt 1):205-21.
doi: 10.1016/0190-9622(91)70185-5.
<span class="bold">PMID: </span><a href="/pubmed/1918456" target="_blank">1918456</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Calcinosis%20cutis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (80)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38587728">Malignant Calcinosis Cutis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Riquelme PA,
Piro K</span><br />
<span class="medgenPMjournal">J Gen Intern Med</span>
2024 Jun;39(8):1519-1520.
Epub 2024 Apr 8
doi: 10.1007/s11606-024-08752-4.
<span class="bold">PMID: </span><a href="/pubmed/38587728" target="_blank">38587728</a><a href="/pmc/articles/PMC11169386" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37278167">Calcinosis cutis of the thumb.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hunter-Dickson M,
Conway J</span><br />
<span class="medgenPMjournal">Med J Aust</span>
2023 Jul 17;219(2):56.
Epub 2023 Jun 6
doi: 10.5694/mja2.51999.
<span class="bold">PMID: </span><a href="/pubmed/37278167" target="_blank">37278167</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32593176">Cutaneous Sarcoidosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Caplan A,
Rosenbach M,
Imadojemu S</span><br />
<span class="medgenPMjournal">Semin Respir Crit Care Med</span>
2020 Oct;41(5):689-699.
Epub 2020 Jun 27
doi: 10.1055/s-0040-1713130.
<span class="bold">PMID: </span><a href="/pubmed/32593176" target="_blank">32593176</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32165190">Calcinosis Cutis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Harada K,
Miyasaka E,
Otsuka F</span><br />
<span class="medgenPMjournal">Am J Med</span>
2020 Sep;133(9):e528-e529.
Epub 2020 Mar 9
doi: 10.1016/j.amjmed.2020.01.040.
<span class="bold">PMID: </span><a href="/pubmed/32165190" target="_blank">32165190</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27507016">Calcinosis cutis universalis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Körber A,
Dissemond J</span><br />
<span class="medgenPMjournal">QJM</span>
2016 Nov;109(11):753.
Epub 2016 Aug 9
doi: 10.1093/qjmed/hcw138.
<span class="bold">PMID: </span><a href="/pubmed/27507016" target="_blank">27507016</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Calcinosis%20cutis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (222)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37261663">Intravenous Immunoglobulin in Idiopathic Inflammatory Myopathies: a Practical Guide for Clinical Use.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gandiga PC,
Ghetie D,
Anderson E,
Aggrawal R</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rep</span>
2023 Aug;25(8):152-168.
Epub 2023 Jun 1
doi: 10.1007/s11926-023-01105-w.
<span class="bold">PMID: </span><a href="/pubmed/37261663" target="_blank">37261663</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32165190">Calcinosis Cutis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Harada K,
Miyasaka E,
Otsuka F</span><br />
<span class="medgenPMjournal">Am J Med</span>
2020 Sep;133(9):e528-e529.
Epub 2020 Mar 9
doi: 10.1016/j.amjmed.2020.01.040.
<span class="bold">PMID: </span><a href="/pubmed/32165190" target="_blank">32165190</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31302187">Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: A review of the literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Traineau H,
Aggarwal R,
Monfort JB,
Senet P,
Oddis CV,
Chizzolini C,
Barbaud A,
Francès C,
Arnaud L,
Chasset F</span><br />
<span class="medgenPMjournal">J Am Acad Dermatol</span>
2020 Feb;82(2):317-325.
Epub 2019 Jul 11
doi: 10.1016/j.jaad.2019.07.006.
<span class="bold">PMID: </span><a href="/pubmed/31302187" target="_blank">31302187</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28361792">Calcinosis Cutis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kumar P</span><br />
<span class="medgenPMjournal">Indian Pediatr</span>
2017 Mar 15;54(3):253.
<span class="bold">PMID: </span><a href="/pubmed/28361792" target="_blank">28361792</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21813938">Calcinosis cutis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vijayalakshmi AM,
Devaprasath S</span><br />
<span class="medgenPMjournal">Indian Pediatr</span>
2011 Jul;48(7):583.
doi: 10.1007/s13312-011-0088-8.
<span class="bold">PMID: </span><a href="/pubmed/21813938" target="_blank">21813938</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Calcinosis%20cutis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (138)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35397096">Clinical and ultrasonography follow-up of five cases of calcinosis cutis successfully treated with intralesional sodium thiosulfate.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tubau C,
Cubiró X,
Amat-Samaranch V,
Garcia-Melendo C,
Puig L,
Roé-Crespo E</span><br />
<span class="medgenPMjournal">J Ultrasound</span>
2022 Dec;25(4):995-1003.
Epub 2022 Apr 9
doi: 10.1007/s40477-022-00665-4.
<span class="bold">PMID: </span><a href="/pubmed/35397096" target="_blank">35397096</a><a href="/pmc/articles/PMC9705646" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32593176">Cutaneous Sarcoidosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Caplan A,
Rosenbach M,
Imadojemu S</span><br />
<span class="medgenPMjournal">Semin Respir Crit Care Med</span>
2020 Oct;41(5):689-699.
Epub 2020 Jun 27
doi: 10.1055/s-0040-1713130.
<span class="bold">PMID: </span><a href="/pubmed/32593176" target="_blank">32593176</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30124603">Calcinosis in scleroderma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Valenzuela A,
Song P,
Chung L</span><br />
<span class="medgenPMjournal">Curr Opin Rheumatol</span>
2018 Nov;30(6):554-561.
doi: 10.1097/BOR.0000000000000539.
<span class="bold">PMID: </span><a href="/pubmed/30124603" target="_blank">30124603</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26632806">Juvenile dermatomyositis with joint contractures and calcinosis cutis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Turan E,
Yesilova Y,
Surucu HA,
Tanrikulu O,
Eroglu N,
Kocarslan S</span><br />
<span class="medgenPMjournal">Dermatol Online J</span>
2015 Oct 16;21(10)
<span class="bold">PMID: </span><a href="/pubmed/26632806" target="_blank">26632806</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21679811">Calcinosis cutis: part II. Treatment options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Reiter N,
El-Shabrawi L,
Leinweber B,
Berghold A,
Aberer E</span><br />
<span class="medgenPMjournal">J Am Acad Dermatol</span>
2011 Jul;65(1):15-22; quiz 23-4.
doi: 10.1016/j.jaad.2010.08.039.
<span class="bold">PMID: </span><a href="/pubmed/21679811" target="_blank">21679811</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Calcinosis%20cutis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (64)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/37830924">Calcinosis in systemic sclerosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Davuluri S,
Lood C,
Chung L</span><br />
<span class="medgenPMjournal">Curr Opin Rheumatol</span>
2024 Sep 1;36(5):360-369.
Epub 2023 Oct 10
doi: 10.1097/BOR.0000000000000900.
<span class="bold">PMID: </span><a href="/pubmed/37830924" target="_blank">37830924</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35993867">Calcinosis in systemic sclerosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Davuluri S,
Lood C,
Chung L</span><br />
<span class="medgenPMjournal">Curr Opin Rheumatol</span>
2022 Nov 1;34(6):319-327.
Epub 2022 Aug 19
doi: 10.1097/BOR.0000000000000896.
<span class="bold">PMID: </span><a href="/pubmed/35993867" target="_blank">35993867</a><a href="/pmc/articles/PMC9547890" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34165603">Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nowaczyk J,
Zawistowski M,
Fiedor P</span><br />
<span class="medgenPMjournal">Arch Dermatol Res</span>
2022 Aug;314(6):515-525.
Epub 2021 Jun 24
doi: 10.1007/s00403-021-02264-5.
<span class="bold">PMID: </span><a href="/pubmed/34165603" target="_blank">34165603</a><a href="/pmc/articles/PMC9232439" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30124603">Calcinosis in scleroderma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Valenzuela A,
Song P,
Chung L</span><br />
<span class="medgenPMjournal">Curr Opin Rheumatol</span>
2018 Nov;30(6):554-561.
doi: 10.1097/BOR.0000000000000539.
<span class="bold">PMID: </span><a href="/pubmed/30124603" target="_blank">30124603</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26352733">Calcinosis: pathophysiology and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Valenzuela A,
Chung L</span><br />
<span class="medgenPMjournal">Curr Opin Rheumatol</span>
2015 Nov;27(6):542-8.
doi: 10.1097/BOR.0000000000000220.
<span class="bold">PMID: </span><a href="/pubmed/26352733" target="_blank">26352733</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Calcinosis%20cutis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (63)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/34165603">Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nowaczyk J,
Zawistowski M,
Fiedor P</span><br />
<span class="medgenPMjournal">Arch Dermatol Res</span>
2022 Aug;314(6):515-525.
Epub 2021 Jun 24
doi: 10.1007/s00403-021-02264-5.
<span class="bold">PMID: </span><a href="/pubmed/34165603" target="_blank">34165603</a><a href="/pmc/articles/PMC9232439" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34210833">Epidemiology and Treatment of Peripheral Neuropathy in Systemic Sclerosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">AlMehmadi BA,
To FZ,
Anderson MA,
Johnson SR</span><br />
<span class="medgenPMjournal">J Rheumatol</span>
2021 Dec;48(12):1839-1849.
Epub 2021 Jul 1
doi: 10.3899/jrheum.201299.
<span class="bold">PMID: </span><a href="/pubmed/34210833" target="_blank">34210833</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31302187">Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: A review of the literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Traineau H,
Aggarwal R,
Monfort JB,
Senet P,
Oddis CV,
Chizzolini C,
Barbaud A,
Francès C,
Arnaud L,
Chasset F</span><br />
<span class="medgenPMjournal">J Am Acad Dermatol</span>
2020 Feb;82(2):317-325.
Epub 2019 Jul 11
doi: 10.1016/j.jaad.2019.07.006.
<span class="bold">PMID: </span><a href="/pubmed/31302187" target="_blank">31302187</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Calcinosis%20cutis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
</div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Calcinosis%20cutis" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22calcinosis%20cutis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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