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<meta name="keywords" content="C1839305, cd8+ t-cell lymphopenia, decreased number of cd8+ t cells, decreased numbers of cd8+ t cells, decreased proportion of cd8+ t cells, decreased proportion of cd8-positive t cells, decreased proportion of cd8-positive, alpha-beta t cells, finding, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A decreased proportion of circulating CD8-positive, alpha-beta T cells relative to total number of T cells." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Decreased proportion of CD8-positive T cells (Concept Id: C1839305)
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<!--
UID=374188
ConceptID=C1839305
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased proportion of CD8-positive T cells</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>374188</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1839305</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>Decreased number of CD8+ T cells</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005415">HP:0005415</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A decreased proportion of circulating CD8-positive, alpha-beta T cells relative to total number of T cells. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased proportion of CD8-positive T cells</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/508852" ref="tree=MeSH" title="MedGen record for Abnormal leukocyte morphology">Abnormal leukocyte morphology</a></span><ul><li><span class="TLline"><a href="/medgen/488926" ref="tree=MeSH" title="MedGen record for Abnormal leukocyte count">Abnormal leukocyte count</a></span><ul><li><span class="TLline"><a href="/medgen/663425" ref="tree=MeSH" title="MedGen record for Abnormal lymphocyte count">Abnormal lymphocyte count</a></span><ul><li><span class="TLline"><a href="/medgen/866762" ref="tree=MeSH" title="MedGen record for Abnormal T cell count">Abnormal T cell count</a></span><ul><li><span class="TLline"><a href="/medgen/1371686" ref="tree=MeSH" title="MedGen record for Abnormal T cell subset distribution">Abnormal T cell subset distribution</a></span><ul><li><span class="TLline"><a href="/medgen/1627283" ref="tree=MeSH" title="MedGen record for Abnormal proportion of CD8-positive T cells">Abnormal proportion of CD8-positive T cells</a></span><ul><li><span class="matched_ds">Decreased proportion of CD8-positive T cells</span><ul><li><span class="TLline"><a href="/medgen/870742" ref="tree=MeSH" title="MedGen record for Absence of CD8-positive T cells">Absence of CD8-positive T cells</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_21921"><div><strong>Wiskott-Aldrich syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21921</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0043194</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The WAS-related disorders, which include Wiskott-Aldrich syndrome, X-linked thrombocytopenia (XLT), and X-linked neutropenia (XLN), are a spectrum of disorders of hematopoietic cells, with predominant defects of platelets and lymphocytes. Wiskott-Aldrich syndrome usually presents in infancy. Affected males have thrombocytopenia with intermittent mucosal bleeding, bloody diarrhea, and intermittent or chronic petechiae and purpura; recurrent bacterial, viral, fungal, and/or opportunistic infections; and eczema. Approximately 25%-40% of those who survive the early complications develop one or more autoimmune conditions including hemolytic anemia, immune thrombocytopenic purpura, immune-mediated neutropenia, vasculitis, rheumatoid arthritis, and immune-mediated damage to the kidneys and liver. Individuals with a WAS-related disorder, particularly those who have been exposed to Epstein-Barr virus (EBV), are at increased risk of developing lymphomas, which often occur in unusual extranodal locations including the brain, lung, or gastrointestinal tract. Males with XLT have small platelet volume and thrombocytopenia. Severe disease-related events include severe bleeding episodes (14%), autoimmunity (12%), life-threatening infections (7%), and malignancy (5%). Males with XLN typically have congenital neutropenia associated with myelodysplasia, hyperactive neutrophils, increased myeloid cell apoptosis, and lymphoid cell abnormalities.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/21921">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_220906"><div><strong>X-linked severe combined immunodeficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>220906</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C1279481</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The phenotypic spectrum of X-linked severe combined immunodeficiency (X-SCID) ranges from typical X-SCID (early-onset disease in males that is fatal if not treated with hematopoietic stem cell transplantation [HSCT] or gene therapy) to atypical X-SCID (later-onset disease comprising phenotypes caused by variable immunodeficiency, immune dysregulation, and/or autoimmunity). Typical X-SCID. Prior to universal newborn screening (NBS) for SCID most males with typical X-SCID came to medical attention between ages three and six months because of recurrent infections, persistent infections, and infections with opportunistic organisms. With universal NBS for SCID, the common presentation for typical X-SCID is now an asymptomatic, healthy-appearing male infant. Atypical X-SCID, which usually is not detected by NBS, can manifest in the first years of life or later with one of the following: recurrent upper and lower respiratory tract infections with bronchiectasis; Omenn syndrome, a clinical phenotype caused by immune dysregulation; X-SCID combined immunodeficiency (often with recurrent infections, warts, and dermatitis); immune dysregulation and autoimmunity; or Epstein-Barr virus-related lymphoproliferative complications.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/220906">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_461506"><div><strong>Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>461506</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3150156</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome is characterised by immune deficiency, gonadal dysgenesis and fatal lung fibrosis. So far, it has been described in two sisters born to consanguineous parents. Both karyotypes were normal female (46,XX). No genetic anomalies could be identified by comparative genome hybridization analysis of their genomes or by analysis of genes known to be associated with these types of anomalies.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/461506">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_482631"><div><strong>Wiskott-Aldrich syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482631</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3281001</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Wiskott-Aldrich syndrome-2 (WAS2) is an autosomal recessive immunologic disorder characterized by onset of recurrent infections in infancy. Other features include thrombocytopenia with normal platelet volume and eczema. Laboratory studies show decreased CD8+ T cells, variably increased Ig, particularly IgE, low B cells, aberrant function of T and NK cells, and impaired T-cell migration. The cellular abnormalities are thought to result from defective F-actin polymerization. Death in early childhood may occur; hematopoietic stem cell transplantation is curative (summary by Lanzi et al., 2012).&#13; For a discussion of genetic heterogeneity of Wiskott-Aldrich syndrome, see WAS (301000).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/482631">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_816437"><div><strong>Combined immunodeficiency due to CD3gamma deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816437</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3810107</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Immunodeficiency-17 (IMD17) is an autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, particularly of cytotoxic CD8 (see 186910)-positive cells, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor (TCR)-dependent stimuli. B cells, natural killer (NK) cells, and immunoglobulins are usually normal. Although thymic output of functional naive T cells early in life is decreased, polyclonal expansion of functional memory T cells is substantial. The phenotype in some patients is reminiscent of severe combined immunodeficiency (SCID) (summary by Timon et al. (1993) and Recio et al. (2007)).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/816437">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_934620"><div><strong>Lung disease, immunodeficiency, and chromosome breakage syndrome;</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934620</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4310653</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">LICS is an autosomal recessive chromosome breakage syndrome characterized by failure to thrive in infancy, immune deficiency, and fatal progressive pediatric lung disease induced by viral infection. Some patients may have mild dysmorphic features (summary by van der Crabben et al., 2016).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/934620">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1648385"><div><strong>Immunodeficiency 15a</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648385</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4748694</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Immunodeficiency 15A (IMD15A) is an autosomal dominant primary immunodeficiency disorder characterized by relatively late onset of recurrent respiratory tract infections and lymphopenia, combined with immune activation of both CD4+ and CD8+ T cells. One patient presented with inflammatory disease and possible ectodermal defect.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1648385">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1802936"><div><strong>Immunodeficiency 97 with autoinflammation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1802936</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5676946</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Immunodeficiency-97 with autoinflammation (IMD97) is an autosomal recessive complex immunologic disorder with variable features. Affected individuals present in the first decade of life with inflammatory interstitial lung disease or colitis due to abnormal tissue infiltration by activated T cells. Patients develop autoimmune cytopenias and may have lymphadenopathy; 1 reported patient had features of hemophagocytic lymphohistiocytosis (HLH; see FHL1, 267700). Some patients may have recurrent infections associated with mild lymphopenia, hypogammaglobulinemia, and NK cell dysfunction. Immunologic workup indicates signs of significant immune dysregulation with elevation of inflammatory serum markers, variable immune cell defects involving neutrophils, NK cells, and myeloid cells, and disrupted levels of T regulatory cells (Tregs). Two unrelated patients have been reported (summary by Takeda et al., 2019 and Thian et al., 2020).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1802936">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816437" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined immunodeficiency due to CD3gamma deficiency</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648385" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 15a</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1802936" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 97 with autoinflammation</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934620" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lung disease, immunodeficiency, and chromosome breakage syndrome;</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_461506" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_21921" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wiskott-Aldrich syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482631" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wiskott-Aldrich syndrome 2</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_220906" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked severe combined immunodeficiency</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/38007423">Characteristics of circulating immune cells in HBV-related acute-on-chronic liver failure following artificial liver treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ju T,
Jiang D,
Zhong C,
Zhang H,
Huang Y,
Zhu C,
Yang S,
Yan D</span><br />
<span class="medgenPMjournal">BMC Immunol</span>
2023 Nov 25;24(1):47.
doi: 10.1186/s12865-023-00579-8.
<span class="bold">PMID: </span><a href="/pubmed/38007423" target="_blank">38007423</a><a href="/pmc/articles/PMC10676598" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36511386">Double-Negative T Cell Number and Phenotype Alterations Before and After Effective Antiretroviral Treatment in Persons Living with HIV.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Briceño O,
Peralta-Prado A,
Garrido-Rodríguez D,
Romero-Mora K,
Chávez-Torres M,
Pinto Cardoso S,
Alvarado de la Barrera C,
Reyes-Terán G,
Ávila-Ríos S</span><br />
<span class="medgenPMjournal">AIDS Res Hum Retroviruses</span>
2023 Mar;39(3):104-113.
Epub 2023 Jan 9
doi: 10.1089/AID.2022.0047.
<span class="bold">PMID: </span><a href="/pubmed/36511386" target="_blank">36511386</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34517748">Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wen Y,
Tang Y,
Li M,
Lai Y</span><br />
<span class="medgenPMjournal">Pharm Biol</span>
2021 Dec;59(1):1276-1285.
doi: 10.1080/13880209.2021.1973039.
<span class="bold">PMID: </span><a href="/pubmed/34517748" target="_blank">34517748</a><a href="/pmc/articles/PMC8451672" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20proportion%20of%20cd8-positive%20t%20cells)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (14)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38637495">The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng B,
Li C,
Li J,
Gong L,
Liang P,
Chen Y,
Zhan S,
Xiong S,
Zhong R,
Liang H,
Feng Y,
Wang R,
Wang H,
Zheng H,
Liu J,
Zhou C,
Shao W,
Qiu Y,
Sun J,
Xie Z,
Liang Z,
Yang C,
Cai X,
Su C,
Wang W,
He J,
Liang W</span><br />
<span class="medgenPMjournal">Signal Transduct Target Ther</span>
2024 Apr 19;9(1):93.
doi: 10.1038/s41392-024-01799-z.
<span class="bold">PMID: </span><a href="/pubmed/38637495" target="_blank">38637495</a><a href="/pmc/articles/PMC11026465" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38110868">Identification of hub genes based on integrated analysis of single-cell and microarray transcriptome in patients with pulmonary arterial hypertension.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Qin Y,
Yan G,
Qiao Y,
Wang D,
Tang C</span><br />
<span class="medgenPMjournal">BMC Genomics</span>
2023 Dec 18;24(1):788.
doi: 10.1186/s12864-023-09892-3.
<span class="bold">PMID: </span><a href="/pubmed/38110868" target="_blank">38110868</a><a href="/pmc/articles/PMC10729354" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37919522">Cholesterol induction in CD8(+) T cell exhaustion in colorectal cancer via the regulation of endoplasmic reticulum-mitochondria contact sites.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shuwen H,
Yinhang W,
Jing Z,
Qiang Y,
Yizhen J,
Quan Q,
Yin J,
Jiang L,
Xi Y</span><br />
<span class="medgenPMjournal">Cancer Immunol Immunother</span>
2023 Dec;72(12):4441-4456.
Epub 2023 Nov 3
doi: 10.1007/s00262-023-03555-8.
<span class="bold">PMID: </span><a href="/pubmed/37919522" target="_blank">37919522</a><a href="/pmc/articles/PMC10991466" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36211422">Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang J,
Kang Z,
Liu Y,
Li Z,
Liu Y,
Liu J</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:956078.
Epub 2022 Sep 23
doi: 10.3389/fimmu.2022.956078.
<span class="bold">PMID: </span><a href="/pubmed/36211422" target="_blank">36211422</a><a href="/pmc/articles/PMC9537477" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35608657">Changes of T lymphocyte subpopulations and their roles in predicting the risk of Parkinson's disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">He Y,
Peng K,
Li R,
Zhang Z,
Pan L,
Zhang T,
Lin A,
Hong R,
Nie Z,
Guan Q,
Jin L</span><br />
<span class="medgenPMjournal">J Neurol</span>
2022 Oct;269(10):5368-5381.
Epub 2022 May 24
doi: 10.1007/s00415-022-11190-z.
<span class="bold">PMID: </span><a href="/pubmed/35608657" target="_blank">35608657</a><a href="/pmc/articles/PMC9467943" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20proportion%20of%20CD8-positive%20T%20cells%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (203)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38877825">Prognostic and therapeutic potential of imbalance between PD-1+CD8 and ICOS+Treg cells in advanced HBV-HCC.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yan F,
Zhu B,
Shi K,
Zhang Y,
Zeng X,
Zhang Q,
Yang Z,
Wang X</span><br />
<span class="medgenPMjournal">Cancer Sci</span>
2024 Aug;115(8):2553-2564.
Epub 2024 Jun 15
doi: 10.1111/cas.16247.
<span class="bold">PMID: </span><a href="/pubmed/38877825" target="_blank">38877825</a><a href="/pmc/articles/PMC11309941" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38590234">Prognostic effect of TCF1+ CD8+ T cell and TOX+ CD8+ T cell infiltration in lung adenocarcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang Y,
Ma L,
Chen Y,
Yun W,
Yu J,
Meng X</span><br />
<span class="medgenPMjournal">Cancer Sci</span>
2024 Jul;115(7):2184-2195.
Epub 2024 Apr 9
doi: 10.1111/cas.16177.
<span class="bold">PMID: </span><a href="/pubmed/38590234" target="_blank">38590234</a><a href="/pmc/articles/PMC11247562" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36211422">Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang J,
Kang Z,
Liu Y,
Li Z,
Liu Y,
Liu J</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:956078.
Epub 2022 Sep 23
doi: 10.3389/fimmu.2022.956078.
<span class="bold">PMID: </span><a href="/pubmed/36211422" target="_blank">36211422</a><a href="/pmc/articles/PMC9537477" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35589692">Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Peng L,
Jin X,
Li BY,
Zeng X,
Liao BH,
Jin T,
Chen JW,
Gao XS,
Wang W,
He Q,
Chen G,
Gong LN,
Shen H,
Wang KJ,
Li H,
Luo DY</span><br />
<span class="medgenPMjournal">Signal Transduct Target Ther</span>
2022 May 20;7(1):161.
doi: 10.1038/s41392-022-00962-8.
<span class="bold">PMID: </span><a href="/pubmed/35589692" target="_blank">35589692</a><a href="/pmc/articles/PMC9120182" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33782107">Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sui Q,
Liu D,
Jiang W,
Tang J,
Kong L,
Han K,
Liao L,
Li Y,
Ou Q,
Xiao B,
Liu G,
Ling Y,
Chen J,
Liu Z,
Zuo Z,
Pan Z,
Zhou P,
Zheng J,
Ding PR</span><br />
<span class="medgenPMjournal">J Immunother Cancer</span>
2021 Mar;9(3)
doi: 10.1136/jitc-2020-001498.
<span class="bold">PMID: </span><a href="/pubmed/33782107" target="_blank">33782107</a><a href="/pmc/articles/PMC8009229" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20proportion%20of%20CD8-positive%20T%20cells%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (80)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38403027">CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xie P,
Yu M,
Zhang B,
Yu Q,
Zhao Y,
Wu M,
Jin L,
Yan J,
Zhou B,
Liu S,
Li X,
Zhou C,
Zhu X,
Huang C,
Xu Y,
Xiao Y,
Zhou J,
Fan J,
Hung MC,
Ye Q,
Guo L,
Li H</span><br />
<span class="medgenPMjournal">J Hepatol</span>
2024 Jul;81(1):93-107.
Epub 2024 Feb 23
doi: 10.1016/j.jhep.2024.02.009.
<span class="bold">PMID: </span><a href="/pubmed/38403027" target="_blank">38403027</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38245530">Macro CD5L(+) deteriorates CD8(+)T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lu JC,
Wu LL,
Sun YN,
Huang XY,
Gao C,
Guo XJ,
Zeng HY,
Qu XD,
Chen Y,
Wu D,
Pei YZ,
Meng XL,
Zheng YM,
Liang C,
Zhang PF,
Cai JB,
Ding ZB,
Yang GH,
Ren N,
Huang C,
Wang XY,
Gao Q,
Sun QM,
Shi YH,
Qiu SJ,
Ke AW,
Shi GM,
Zhou J,
Sun YD,
Fan J</span><br />
<span class="medgenPMjournal">Nat Commun</span>
2024 Jan 20;15(1):621.
doi: 10.1038/s41467-024-44795-1.
<span class="bold">PMID: </span><a href="/pubmed/38245530" target="_blank">38245530</a><a href="/pmc/articles/PMC10799889" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36211422">Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang J,
Kang Z,
Liu Y,
Li Z,
Liu Y,
Liu J</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:956078.
Epub 2022 Sep 23
doi: 10.3389/fimmu.2022.956078.
<span class="bold">PMID: </span><a href="/pubmed/36211422" target="_blank">36211422</a><a href="/pmc/articles/PMC9537477" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35619708">Landscape of Immune Cells Heterogeneity in Liver Transplantation by Single-Cell RNA Sequencing Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li X,
Li S,
Wu B,
Xu Q,
Teng D,
Yang T,
Sun Y,
Zhao Y,
Li T,
Liu D,
Yang S,
Gong W,
Cai J</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:890019.
Epub 2022 May 10
doi: 10.3389/fimmu.2022.890019.
<span class="bold">PMID: </span><a href="/pubmed/35619708" target="_blank">35619708</a><a href="/pmc/articles/PMC9127089" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33782107">Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sui Q,
Liu D,
Jiang W,
Tang J,
Kong L,
Han K,
Liao L,
Li Y,
Ou Q,
Xiao B,
Liu G,
Ling Y,
Chen J,
Liu Z,
Zuo Z,
Pan Z,
Zhou P,
Zheng J,
Ding PR</span><br />
<span class="medgenPMjournal">J Immunother Cancer</span>
2021 Mar;9(3)
doi: 10.1136/jitc-2020-001498.
<span class="bold">PMID: </span><a href="/pubmed/33782107" target="_blank">33782107</a><a href="/pmc/articles/PMC8009229" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20proportion%20of%20CD8-positive%20T%20cells%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (151)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38245530">Macro CD5L(+) deteriorates CD8(+)T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lu JC,
Wu LL,
Sun YN,
Huang XY,
Gao C,
Guo XJ,
Zeng HY,
Qu XD,
Chen Y,
Wu D,
Pei YZ,
Meng XL,
Zheng YM,
Liang C,
Zhang PF,
Cai JB,
Ding ZB,
Yang GH,
Ren N,
Huang C,
Wang XY,
Gao Q,
Sun QM,
Shi YH,
Qiu SJ,
Ke AW,
Shi GM,
Zhou J,
Sun YD,
Fan J</span><br />
<span class="medgenPMjournal">Nat Commun</span>
2024 Jan 20;15(1):621.
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Wei H,
Suo C,
Shen S,
Zhu C,
Chen L,
Yan K,
Li Z,
Bian Z,
Zhang P,
Yuan M,
Yu Y,
Du J,
Zhang H,
Sun L,
Gao P</span><br />
<span class="medgenPMjournal">Nat Commun</span>
2023 Dec 9;14(1):8154.
doi: 10.1038/s41467-023-43988-4.
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<div class="portlet_content ln"><span class="medgenPMauthor">Wang J,
Kang Z,
Liu Y,
Li Z,
Liu Y,
Liu J</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:956078.
Epub 2022 Sep 23
doi: 10.3389/fimmu.2022.956078.
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Peng K,
Li R,
Zhang Z,
Pan L,
Zhang T,
Lin A,
Hong R,
Nie Z,
Guan Q,
Jin L</span><br />
<span class="medgenPMjournal">J Neurol</span>
2022 Oct;269(10):5368-5381.
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doi: 10.1007/s00415-022-11190-z.
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<div class="portlet_content ln"><span class="medgenPMauthor">Sui Q,
Liu D,
Jiang W,
Tang J,
Kong L,
Han K,
Liao L,
Li Y,
Ou Q,
Xiao B,
Liu G,
Ling Y,
Chen J,
Liu Z,
Zuo Z,
Pan Z,
Zhou P,
Zheng J,
Ding PR</span><br />
<span class="medgenPMjournal">J Immunother Cancer</span>
2021 Mar;9(3)
doi: 10.1136/jitc-2020-001498.
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<div class="nl"><a target="_blank" href="/pubmed/38245530">Macro CD5L(+) deteriorates CD8(+)T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lu JC,
Wu LL,
Sun YN,
Huang XY,
Gao C,
Guo XJ,
Zeng HY,
Qu XD,
Chen Y,
Wu D,
Pei YZ,
Meng XL,
Zheng YM,
Liang C,
Zhang PF,
Cai JB,
Ding ZB,
Yang GH,
Ren N,
Huang C,
Wang XY,
Gao Q,
Sun QM,
Shi YH,
Qiu SJ,
Ke AW,
Shi GM,
Zhou J,
Sun YD,
Fan J</span><br />
<span class="medgenPMjournal">Nat Commun</span>
2024 Jan 20;15(1):621.
doi: 10.1038/s41467-024-44795-1.
<span class="bold">PMID: </span><a href="/pubmed/38245530" target="_blank">38245530</a><a href="/pmc/articles/PMC10799889" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38071226">Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8(+) T-cell exhaustion.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gu X,
Wei H,
Suo C,
Shen S,
Zhu C,
Chen L,
Yan K,
Li Z,
Bian Z,
Zhang P,
Yuan M,
Yu Y,
Du J,
Zhang H,
Sun L,
Gao P</span><br />
<span class="medgenPMjournal">Nat Commun</span>
2023 Dec 9;14(1):8154.
doi: 10.1038/s41467-023-43988-4.
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<div class="nl"><a target="_blank" href="/pubmed/37919522">Cholesterol induction in CD8(+) T cell exhaustion in colorectal cancer via the regulation of endoplasmic reticulum-mitochondria contact sites.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shuwen H,
Yinhang W,
Jing Z,
Qiang Y,
Yizhen J,
Quan Q,
Yin J,
Jiang L,
Xi Y</span><br />
<span class="medgenPMjournal">Cancer Immunol Immunother</span>
2023 Dec;72(12):4441-4456.
Epub 2023 Nov 3
doi: 10.1007/s00262-023-03555-8.
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<div class="nl"><a target="_blank" href="/pubmed/36211422">Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang J,
Kang Z,
Liu Y,
Li Z,
Liu Y,
Liu J</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:956078.
Epub 2022 Sep 23
doi: 10.3389/fimmu.2022.956078.
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<div class="nl"><a target="_blank" href="/pubmed/33782107">Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sui Q,
Liu D,
Jiang W,
Tang J,
Kong L,
Han K,
Liao L,
Li Y,
Ou Q,
Xiao B,
Liu G,
Ling Y,
Chen J,
Liu Z,
Zuo Z,
Pan Z,
Zhou P,
Zheng J,
Ding PR</span><br />
<span class="medgenPMjournal">J Immunother Cancer</span>
2021 Mar;9(3)
doi: 10.1136/jitc-2020-001498.
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<div class="nl"><a target="_blank" href="/pubmed/38270322">Efficacy, safety and the lymphocyte subsets changes of low-dose IL-2 in patients with systemic lupus erythematosus: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Su QY,
Luo J,
Wang XM,
Di JK,
Cao YX,
Zhang SX</span><br />
<span class="medgenPMjournal">Immun Inflamm Dis</span>
2024 Jan;12(1):e1165.
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<div class="portlet_content ln"><span class="medgenPMauthor">Wen Y,
Tang Y,
Li M,
Lai Y</span><br />
<span class="medgenPMjournal">Pharm Biol</span>
2021 Dec;59(1):1276-1285.
doi: 10.1080/13880209.2021.1973039.
<span class="bold">PMID: </span><a href="/pubmed/34517748" target="_blank">34517748</a><a href="/pmc/articles/PMC8451672" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20proportion%20of%20cd8-positive%20t%20cells)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Decreased%20proportion%20of%20CD8-positive%20T%20cells%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="ralinkpop offscreen_noflow">RecName: Full=Cytokine receptor common subunit gamma; AltName: Full=Interleukin-2 receptor subunit gamma; Short=IL-2 receptor subunit gamma; Short=IL-2R subunit gamma; Short=IL-2RG; AltName: Full=gammaC; AltName: Full=p64; AltName: CD_antigen=CD132; Flags: Precursor<div class="brieflinkpopdesc">gi|400048|sp|P31785.1|IL2RG_HUMAN</div></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d5add5cde49f3df75e9130">X-linked severe combined immunodeficiency</a>
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