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<meta name="keywords" content="C0853068, decreased gfr, decreased glomerular filtration rate, finding, glomerular filtration rate below reference range, glomerular filtration rate decreased, glomerular filtration rate, decreased, impaired renal creatinine clearance, reduced creatinine clearance, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An abnormal reduction in the volume of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=163428
|
||
ConceptID=C0853068
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased glomerular filtration rate</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163428</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0853068</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Decreased GFR; Glomerular filtration rate, decreased; Impaired renal creatinine clearance; Reduced creatinine clearance</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Glomerular filtration rate decreased (863929001); Glomerular filtration rate below reference range (863929001)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012213">HP:0012213</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">An abnormal reduction in the volume of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased glomerular filtration rate</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/52948" ref="tree=MeSH" title="MedGen record for Abnormality of the genitourinary system">Abnormality of the genitourinary system</a></span><ul><li><span class="TLline"><a href="/medgen/867444" ref="tree=MeSH" title="MedGen record for Abnormality of the urinary system">Abnormality of the urinary system</a></span><ul><li><span class="TLline"><a href="/medgen/869020" ref="tree=MeSH" title="MedGen record for Abnormality of the urinary system physiology">Abnormality of the urinary system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/508816" ref="tree=MeSH" title="MedGen record for Abnormal renal physiology">Abnormal renal physiology</a></span><ul><li><span class="TLline"><a href="/medgen/489765" ref="tree=MeSH" title="MedGen record for Abnormal glomerular filtration rate">Abnormal glomerular filtration rate</a></span><ul><li><span class="matched_ds">Decreased glomerular filtration rate</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_1413"><div><strong>Alkaptonuria</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1413</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0002066</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Alkaptonuria is caused by deficiency of homogentisate 1,2-dioxygenase, an enzyme that converts homogentisic acid (HGA) to maleylacetoacetic acid in the tyrosine degradation pathway. The three major features of alkaptonuria are dark urine or urine that turns dark on standing, ochronosis (bluish-black pigmentation in connective tissue), and arthritis of the spine and larger joints. Ochronosis generally occurs after age 30 years; arthritis often begins in the third decade. Other manifestations can include pigment in the sclera, ear cartilage, and skin of the hands; aortic or mitral valve calcification or regurgitation and occasionally aortic dilatation; renal stones; prostate stones; and hypothyroidism.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1413">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78644"><div><strong>Glucose-6-phosphate transport defect</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78644</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268146</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Glycogen storage disease type I (GSD I) is characterized by accumulation of glycogen and fat in the liver and kidneys resulting in hepatomegaly and nephromegaly. Severely affected infants present in the neonatal period with severe hypoglycemia due to fasting intolerance. More commonly, untreated infants present at age three to four months with hepatomegaly, severe hypoglycemia with or without seizures, lactic acidosis, hyperuricemia, and hypertriglyceridemia. Affected children typically have doll-like faces with full cheeks, relatively thin extremities, short stature, and a protuberant abdomen. Xanthoma and diarrhea may be present. Impaired platelet function and development of reduced or dysfunctional von Willebrand factor can lead to a bleeding tendency with frequent epistaxis and menorrhagia in females. Individuals with untreated GSD Ib are more likely to develop impaired neutrophil and monocyte function as well as chronic neutropenia resulting in recurrent bacterial infections, gingivitis, periodontitis, and genital and intestinal ulcers. Long-term complications of untreated GSD I include short stature, osteoporosis, delayed puberty, renal disease (including proximal and distal renal tubular acidosis, renal stones, and kidney failure), gout, systemic hypertension, pulmonary hypertension, hepatic adenomas with potential for malignancy, pancreatitis, and polycystic ovaries. Seizures and cognitive impairment may occur in individuals with prolonged periods of hypoglycemia. Normal growth and puberty are expected in treated children. Most affected individuals live into adulthood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78644">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_87438"><div><strong>Autosomal dominant hypocalcemia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87438</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342345</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant hypocalcemia-1 (HYPOC1) is associated with low or normal serum parathyroid hormone concentrations (PTH). Approximately 50% of patients have mild or asymptomatic hypocalcemia; about 50% have paresthesias, carpopedal spasm, and seizures; about 10% have hypercalciuria with nephrocalcinosis or kidney stones; and more than 35% have ectopic and basal ganglia calcifications (summary by Nesbit et al., 2013). Thakker (2001) noted that patients with gain-of-function mutations in the CASR gene, resulting in generally asymptomatic hypocalcemia with hypercalciuria, have low-normal serum PTH concentrations and have often been diagnosed with hypoparathyroidism because of the insensitivity of earlier PTH assays. Because treatment with vitamin D to correct the hypocalcemia in these patients causes hypercalciuria, nephrocalcinosis, and renal impairment, these patients need to be distinguished from those with other forms of hypoparathyroidism (see 146200). Thakker (2001) suggested the designation 'autosomal dominant hypocalcemic hypercalciuria' for this CASR-related disorder. Genetic Heterogeneity of Autosomal Dominant Hypocalcemia Autosomal dominant hypocalcemia-2 (HYPOC2; 615361) is caused by mutation in the GNA11 gene (139313) on chromosome 19p13.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/87438">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_87455"><div><strong>Phosphate transport defect</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87455</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342749</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Glycogenosis due to glucose-6-phosphatase deficiency (G6P) type b, or glycogen storage disease (GSD) type 1b, is a type of glycogenosis due to G6P deficiency (see this term).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/87455">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_340966"><div><strong>Ichthyosis-intellectual disability-dwarfism-renal impairment syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>340966</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1855787</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ichthyosis-intellectual disability-dwarfism-renal impairment syndrome is characterised by nonbullous congenital ichthyosis, intellectual deficit, dwarfism and renal impairment. It has been described in four members of one Iranian family. Transmission is autosomal recessive.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/340966">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_355430"><div><strong>Bartter disease type 4A</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355430</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1865270</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bartter syndrome refers to a group of disorders that are unified by autosomal recessive transmission of impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and hypercalciuria. Clinical disease results from defective renal reabsorption of sodium chloride in the thick ascending limb (TAL) of the Henle loop, where 30% of filtered salt is normally reabsorbed (Simon et al., 1997). Patients with antenatal (or neonatal) forms of Bartter syndrome typically present with premature birth associated with polyhydramnios and low birth weight and may develop life-threatening dehydration in the neonatal period. Patients with classic Bartter syndrome (see BARTS3, 607364) present later in life and may be sporadically asymptomatic or mildly symptomatic (summary by Simon et al., 1996 and Fremont and Chan, 2012). For a discussion of genetic heterogeneity of Bartter syndrome, see 607364.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/355430">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_358137"><div><strong>Tubulointerstitial kidney disease, autosomal dominant, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>358137</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1868139</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant tubulointerstitial kidney disease – MUC1 (ADTKD-MUC1) is characterized by slowly progressive tubulointerstitial disease that leads to end-stage renal disease (ESRD) and the need for dialysis or kidney transplantation. The rate of loss of kidney function for individuals is variable within and between families, with a median age of onset of end-stage renal disease (ESRD) of 46 years (range: ages 20-70 years). There are no other systemic manifestations.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/358137">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_415885"><div><strong>Glycogen storage disease due to glucose-6-phosphatase deficiency type IA</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>415885</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2919796</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Glycogen storage disease type I (GSD I) is characterized by accumulation of glycogen and fat in the liver and kidneys resulting in hepatomegaly and nephromegaly. Severely affected infants present in the neonatal period with severe hypoglycemia due to fasting intolerance. More commonly, untreated infants present at age three to four months with hepatomegaly, severe hypoglycemia with or without seizures, lactic acidosis, hyperuricemia, and hypertriglyceridemia. Affected children typically have doll-like faces with full cheeks, relatively thin extremities, short stature, and a protuberant abdomen. Xanthoma and diarrhea may be present. Impaired platelet function and development of reduced or dysfunctional von Willebrand factor can lead to a bleeding tendency with frequent epistaxis and menorrhagia in females. Individuals with untreated GSD Ib are more likely to develop impaired neutrophil and monocyte function as well as chronic neutropenia resulting in recurrent bacterial infections, gingivitis, periodontitis, and genital and intestinal ulcers. Long-term complications of untreated GSD I include short stature, osteoporosis, delayed puberty, renal disease (including proximal and distal renal tubular acidosis, renal stones, and kidney failure), gout, systemic hypertension, pulmonary hypertension, hepatic adenomas with potential for malignancy, pancreatitis, and polycystic ovaries. Seizures and cognitive impairment may occur in individuals with prolonged periods of hypoglycemia. Normal growth and puberty are expected in treated children. Most affected individuals live into adulthood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/415885">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462002"><div><strong>Fanconi renotubular syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462002</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150652</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any Fanconi syndrome in which the cause of the disease is a mutation in the SLC34A1 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462002">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934708"><div><strong>Hyperuricemic nephropathy, familial juvenile type 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934708</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310741</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant tubulointerstitial kidney disease-5 (ADTKD5) is characterized by the onset of progressive chronic renal disease in the first decades of life. Mild hyperuricemia may be present, but gout, hypertension, and proteinuria are usually absent. The disease may be associated with anemia or neutropenia. Some patients may have additional findings, including poor overall growth and impaired cognitive function. Renal biopsy shows tubulointerstitial abnormalities with atrophic tubules and fibrosis; secondary glomerular abnormalities and simple cysts may also be present (summary by Bolar et al., 2016). For a discussion of genetic heterogeneity and revised nomenclature of ADTKD, see ADTKD1 (162000).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934708">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934772"><div><strong>Bartter disease type 4B</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934772</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310805</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bartter syndrome refers to a group of disorders that are unified by autosomal recessive transmission of impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and hypercalciuria. Clinical disease results from defective renal reabsorption of sodium chloride in the thick ascending limb (TAL) of the Henle loop, where 30% of filtered salt is normally reabsorbed (Simon et al., 1997). Patients with antenatal (or neonatal) forms of Bartter syndrome (e.g., BARTS1, 601678) typically present with premature birth associated with polyhydramnios and low birth weight and may develop life-threatening dehydration in the neonatal period. Patients with classic Bartter syndrome present later in life and may be sporadically asymptomatic or mildly symptomatic (summary by Simon et al., 1996 and Fremont and Chan, 2012). For a discussion of genetic heterogeneity of Bartter syndrome, see 607364.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934772">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1388385"><div><strong>Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1388385</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4518785</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Junctional epidermolysis bullosa-7 with interstitial lung disease and nephrotic syndrome (JEB7), also known as ILNEB, is an autosomal recessive multiorgan disorder that includes congenital interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease (summary by Has et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1388385">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1645893"><div><strong>Familial juvenile hyperuricemic nephropathy type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1645893</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551496</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant tubulointerstitial kidney disease – UMOD (ADTKD-UMOD) is characterized by normal urinalysis and slowly progressive chronic kidney disease (CKD), usually first noted in the teen years and progressing to end-stage renal disease (ESRD) between the third and seventh decades. Hyperuricemia is often present from an early age, and gout (resulting from reduced kidney excretion of uric acid) occurs in the teenage years in about 8% of affected individuals and develops in 55% of affected individuals over time.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1645893">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648469"><div><strong>Polycystic kidney disease 6 with or without polycystic liver disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648469</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4748044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant polycystic kidney disease (ADPKD) is generally a late-onset multisystem disorder characterized by bilateral kidney cysts, liver cysts, and an increased risk of intracranial aneurysms. Other manifestations include: cysts in the pancreas, seminal vesicles, and arachnoid membrane; dilatation of the aortic root and dissection of the thoracic aorta; mitral valve prolapse; and abdominal wall hernias. Kidney manifestations include early-onset hypertension, kidney pain, and kidney insufficiency. Approximately 50% of individuals with ADPKD have end-stage kidney disease (ESKD) by age 60 years. The prevalence of liver cysts increases with age and occasionally results in clinically significant severe polycystic liver disease (PLD), most often in females. Overall, the prevalence of intracranial aneurysms is fivefold higher than in the general population and further increased in those with a positive family history of aneurysms or subarachnoid hemorrhage. There is substantial variability in the severity of kidney disease and other extra-kidney manifestations.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648469">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648282"><div><strong>Orthostatic hypotension 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648282</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4748569</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Orthostatic hypotension-2 is an autosomal recessive disorder characterized by severe orthostatic hypotension, recurrent hypoglycemia, and low norepinephrine levels. The disorder has onset in infancy or early childhood. Some patients may also have renal dysfunction and reduced life expectancy. The disorder results from a defect in the biosynthesis of norepinephrine from dopamine due to a cofactor deficiency. For a discussion of genetic heterogeneity of ORTHYP, see ORTHYP1 (223360).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648282">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1413" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alkaptonuria</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_87438" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant hypocalcemia 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355430" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bartter disease type 4A</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934772" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bartter disease type 4B</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1388385" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (15)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1645893" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial juvenile hyperuricemic nephropathy type 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462002" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi renotubular syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78644" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glucose-6-phosphate transport defect</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_415885" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glycogen storage disease due to glucose-6-phosphatase deficiency type IA</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934708" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperuricemic nephropathy, familial juvenile type 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_340966" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ichthyosis-intellectual disability-dwarfism-renal impairment syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648282" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Orthostatic hypotension 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_87455" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Phosphate transport defect</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648469" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polycystic kidney disease 6 with or without polycystic liver disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_358137" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tubulointerstitial kidney disease, autosomal dominant, 2</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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||
<div class="nl"><a target="_blank" href="/pubmed/33596757">The pathophysiology and management of diuretic resistance in patients with heart failure.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chrysant SG,
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||
Chrysant GS</span><br />
|
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<span class="medgenPMjournal">Hosp Pract (1995)</span>
|
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2022 Apr;50(2):93-101.
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Epub 2021 Apr 12
|
||
doi: 10.1080/21548331.2021.1893065.
|
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<span class="bold">PMID: </span><a href="/pubmed/33596757" target="_blank">33596757</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32409237">Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Levey AS,
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Eckardt KU,
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Dorman NM,
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Christiansen SL,
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Hoorn EJ,
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Ingelfinger JR,
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Inker LA,
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Levin A,
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Mehrotra R,
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Palevsky PM,
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Perazella MA,
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Tong A,
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Allison SJ,
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Bockenhauer D,
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Briggs JP,
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Bromberg JS,
|
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Davenport A,
|
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Feldman HI,
|
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Fouque D,
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Gansevoort RT,
|
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Gill JS,
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Greene EL,
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Hemmelgarn BR,
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Kretzler M,
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Lambie M,
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Lane PH,
|
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Laycock J,
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Leventhal SE,
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Mittelman M,
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Morrissey P,
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||
Ostermann M,
|
||
Rees L,
|
||
Ronco P,
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Schaefer F,
|
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St Clair Russell J,
|
||
Vinck C,
|
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Walsh SB,
|
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Weiner DE,
|
||
Cheung M,
|
||
Jadoul M,
|
||
Winkelmayer WC</span><br />
|
||
<span class="medgenPMjournal">Kidney Int</span>
|
||
2020 Jun;97(6):1117-1129.
|
||
Epub 2020 Mar 9
|
||
doi: 10.1016/j.kint.2020.02.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32409237" target="_blank">32409237</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24647050">KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Inker LA,
|
||
Astor BC,
|
||
Fox CH,
|
||
Isakova T,
|
||
Lash JP,
|
||
Peralta CA,
|
||
Kurella Tamura M,
|
||
Feldman HI</span><br />
|
||
<span class="medgenPMjournal">Am J Kidney Dis</span>
|
||
2014 May;63(5):713-35.
|
||
Epub 2014 Mar 16
|
||
doi: 10.1053/j.ajkd.2014.01.416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24647050" target="_blank">24647050</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22decreased%20glomerular%20filtration%20rate%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (31)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32609313">Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Banach M,
|
||
Duell PB,
|
||
Gotto AM Jr,
|
||
Laufs U,
|
||
Leiter LA,
|
||
Mancini GBJ,
|
||
Ray KK,
|
||
Flaim J,
|
||
Ye Z,
|
||
Catapano AL</span><br />
|
||
<span class="medgenPMjournal">JAMA Cardiol</span>
|
||
2020 Oct 1;5(10):1124-1135.
|
||
doi: 10.1001/jamacardio.2020.2314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32609313" target="_blank">32609313</a><a href="/pmc/articles/PMC7330832" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30419237">Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 2: Air Pollution and Organ Systems.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schraufnagel DE,
|
||
Balmes JR,
|
||
Cowl CT,
|
||
De Matteis S,
|
||
Jung SH,
|
||
Mortimer K,
|
||
Perez-Padilla R,
|
||
Rice MB,
|
||
Riojas-Rodriguez H,
|
||
Sood A,
|
||
Thurston GD,
|
||
To T,
|
||
Vanker A,
|
||
Wuebbles DJ</span><br />
|
||
<span class="medgenPMjournal">Chest</span>
|
||
2019 Feb;155(2):417-426.
|
||
Epub 2018 Nov 9
|
||
doi: 10.1016/j.chest.2018.10.041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30419237" target="_blank">30419237</a><a href="/pmc/articles/PMC6904854" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27864708">Thyroid dysfunction and kidney disease: An update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Iglesias P,
|
||
Bajo MA,
|
||
Selgas R,
|
||
Díez JJ</span><br />
|
||
<span class="medgenPMjournal">Rev Endocr Metab Disord</span>
|
||
2017 Mar;18(1):131-144.
|
||
doi: 10.1007/s11154-016-9395-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27864708" target="_blank">27864708</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24647050">KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Inker LA,
|
||
Astor BC,
|
||
Fox CH,
|
||
Isakova T,
|
||
Lash JP,
|
||
Peralta CA,
|
||
Kurella Tamura M,
|
||
Feldman HI</span><br />
|
||
<span class="medgenPMjournal">Am J Kidney Dis</span>
|
||
2014 May;63(5):713-35.
|
||
Epub 2014 Mar 16
|
||
doi: 10.1053/j.ajkd.2014.01.416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24647050" target="_blank">24647050</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21896148">Angiotensin-converting enzyme inhibitors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Izzo JL Jr,
|
||
Weir MR</span><br />
|
||
<span class="medgenPMjournal">J Clin Hypertens (Greenwich)</span>
|
||
2011 Sep;13(9):667-75.
|
||
Epub 2011 Jul 18
|
||
doi: 10.1111/j.1751-7176.2011.00508.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21896148" target="_blank">21896148</a><a href="/pmc/articles/PMC8108813" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20glomerular%20filtration%20rate%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (275)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37088529">Biomarkers in Polycystic Kidney Disease: Are We There?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu ASL,
|
||
Landsittel DP</span><br />
|
||
<span class="medgenPMjournal">Adv Kidney Dis Health</span>
|
||
2023 May;30(3):285-293.
|
||
doi: 10.1053/j.akdh.2022.12.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37088529" target="_blank">37088529</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32609313">Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Banach M,
|
||
Duell PB,
|
||
Gotto AM Jr,
|
||
Laufs U,
|
||
Leiter LA,
|
||
Mancini GBJ,
|
||
Ray KK,
|
||
Flaim J,
|
||
Ye Z,
|
||
Catapano AL</span><br />
|
||
<span class="medgenPMjournal">JAMA Cardiol</span>
|
||
2020 Oct 1;5(10):1124-1135.
|
||
doi: 10.1001/jamacardio.2020.2314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32609313" target="_blank">32609313</a><a href="/pmc/articles/PMC7330832" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32409237">Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Levey AS,
|
||
Eckardt KU,
|
||
Dorman NM,
|
||
Christiansen SL,
|
||
Hoorn EJ,
|
||
Ingelfinger JR,
|
||
Inker LA,
|
||
Levin A,
|
||
Mehrotra R,
|
||
Palevsky PM,
|
||
Perazella MA,
|
||
Tong A,
|
||
Allison SJ,
|
||
Bockenhauer D,
|
||
Briggs JP,
|
||
Bromberg JS,
|
||
Davenport A,
|
||
Feldman HI,
|
||
Fouque D,
|
||
Gansevoort RT,
|
||
Gill JS,
|
||
Greene EL,
|
||
Hemmelgarn BR,
|
||
Kretzler M,
|
||
Lambie M,
|
||
Lane PH,
|
||
Laycock J,
|
||
Leventhal SE,
|
||
Mittelman M,
|
||
Morrissey P,
|
||
Ostermann M,
|
||
Rees L,
|
||
Ronco P,
|
||
Schaefer F,
|
||
St Clair Russell J,
|
||
Vinck C,
|
||
Walsh SB,
|
||
Weiner DE,
|
||
Cheung M,
|
||
Jadoul M,
|
||
Winkelmayer WC</span><br />
|
||
<span class="medgenPMjournal">Kidney Int</span>
|
||
2020 Jun;97(6):1117-1129.
|
||
Epub 2020 Mar 9
|
||
doi: 10.1016/j.kint.2020.02.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32409237" target="_blank">32409237</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15821418">Screening for kidney disease in adults with diabetes and prediabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kramer H</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Nephrol Hypertens</span>
|
||
2005 May;14(3):249-52.
|
||
doi: 10.1097/01.mnh.0000165891.67878.7f.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15821418" target="_blank">15821418</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1576767">Nephrocalcinosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Adams ND,
|
||
Rowe JC</span><br />
|
||
<span class="medgenPMjournal">Clin Perinatol</span>
|
||
1992 Mar;19(1):179-95.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1576767" target="_blank">1576767</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20glomerular%20filtration%20rate%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (141)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37088529">Biomarkers in Polycystic Kidney Disease: Are We There?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu ASL,
|
||
Landsittel DP</span><br />
|
||
<span class="medgenPMjournal">Adv Kidney Dis Health</span>
|
||
2023 May;30(3):285-293.
|
||
doi: 10.1053/j.akdh.2022.12.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37088529" target="_blank">37088529</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32609313">Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Banach M,
|
||
Duell PB,
|
||
Gotto AM Jr,
|
||
Laufs U,
|
||
Leiter LA,
|
||
Mancini GBJ,
|
||
Ray KK,
|
||
Flaim J,
|
||
Ye Z,
|
||
Catapano AL</span><br />
|
||
<span class="medgenPMjournal">JAMA Cardiol</span>
|
||
2020 Oct 1;5(10):1124-1135.
|
||
doi: 10.1001/jamacardio.2020.2314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32609313" target="_blank">32609313</a><a href="/pmc/articles/PMC7330832" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30419237">Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 2: Air Pollution and Organ Systems.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schraufnagel DE,
|
||
Balmes JR,
|
||
Cowl CT,
|
||
De Matteis S,
|
||
Jung SH,
|
||
Mortimer K,
|
||
Perez-Padilla R,
|
||
Rice MB,
|
||
Riojas-Rodriguez H,
|
||
Sood A,
|
||
Thurston GD,
|
||
To T,
|
||
Vanker A,
|
||
Wuebbles DJ</span><br />
|
||
<span class="medgenPMjournal">Chest</span>
|
||
2019 Feb;155(2):417-426.
|
||
Epub 2018 Nov 9
|
||
doi: 10.1016/j.chest.2018.10.041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30419237" target="_blank">30419237</a><a href="/pmc/articles/PMC6904854" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21896148">Angiotensin-converting enzyme inhibitors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Izzo JL Jr,
|
||
Weir MR</span><br />
|
||
<span class="medgenPMjournal">J Clin Hypertens (Greenwich)</span>
|
||
2011 Sep;13(9):667-75.
|
||
Epub 2011 Jul 18
|
||
doi: 10.1111/j.1751-7176.2011.00508.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21896148" target="_blank">21896148</a><a href="/pmc/articles/PMC8108813" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11262555">Metabolic alkalosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khanna A,
|
||
Kurtzman NA</span><br />
|
||
<span class="medgenPMjournal">Respir Care</span>
|
||
2001 Apr;46(4):354-65.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11262555" target="_blank">11262555</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20glomerular%20filtration%20rate%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (154)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37452416">Epidemiology of the first-ever cardiovascular event in people with type 1 diabetes: a retrospective cohort population-based study in Catalonia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giménez-Pérez G,
|
||
Viñals C,
|
||
Mata-Cases M,
|
||
Vlacho B,
|
||
Real J,
|
||
Franch-Nadal J,
|
||
Ortega E,
|
||
Mauricio D</span><br />
|
||
<span class="medgenPMjournal">Cardiovasc Diabetol</span>
|
||
2023 Jul 14;22(1):179.
|
||
doi: 10.1186/s12933-023-01917-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37452416" target="_blank">37452416</a><a href="/pmc/articles/PMC10349453" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37088529">Biomarkers in Polycystic Kidney Disease: Are We There?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu ASL,
|
||
Landsittel DP</span><br />
|
||
<span class="medgenPMjournal">Adv Kidney Dis Health</span>
|
||
2023 May;30(3):285-293.
|
||
doi: 10.1053/j.akdh.2022.12.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37088529" target="_blank">37088529</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30419237">Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 2: Air Pollution and Organ Systems.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schraufnagel DE,
|
||
Balmes JR,
|
||
Cowl CT,
|
||
De Matteis S,
|
||
Jung SH,
|
||
Mortimer K,
|
||
Perez-Padilla R,
|
||
Rice MB,
|
||
Riojas-Rodriguez H,
|
||
Sood A,
|
||
Thurston GD,
|
||
To T,
|
||
Vanker A,
|
||
Wuebbles DJ</span><br />
|
||
<span class="medgenPMjournal">Chest</span>
|
||
2019 Feb;155(2):417-426.
|
||
Epub 2018 Nov 9
|
||
doi: 10.1016/j.chest.2018.10.041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30419237" target="_blank">30419237</a><a href="/pmc/articles/PMC6904854" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16736446">Metabolic alkalosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khanna A,
|
||
Kurtzman NA</span><br />
|
||
<span class="medgenPMjournal">J Nephrol</span>
|
||
2006 Mar-Apr;19 Suppl 9:S86-96.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16736446" target="_blank">16736446</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1576767">Nephrocalcinosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Adams ND,
|
||
Rowe JC</span><br />
|
||
<span class="medgenPMjournal">Clin Perinatol</span>
|
||
1992 Mar;19(1):179-95.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1576767" target="_blank">1576767</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20glomerular%20filtration%20rate%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (154)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37926452">Prevalence of stroke among patients with chronic kidney disease, Taif, Saudi Arabia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mubaraki AA,
|
||
Alotaibi WD,
|
||
Sibyani AK,
|
||
Alrbaiai GT,
|
||
Almalki HS,
|
||
Atallah HM,
|
||
Basfar AS,
|
||
Alqaedi A,
|
||
Althobaiti HA,
|
||
Algethami MM,
|
||
Althobaiti YA</span><br />
|
||
<span class="medgenPMjournal">Saudi Med J</span>
|
||
2023 Nov;44(11):1139-1144.
|
||
doi: 10.15537/smj.2023.44.11.20230206.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37926452" target="_blank">37926452</a><a href="/pmc/articles/PMC10712769" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37452416">Epidemiology of the first-ever cardiovascular event in people with type 1 diabetes: a retrospective cohort population-based study in Catalonia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giménez-Pérez G,
|
||
Viñals C,
|
||
Mata-Cases M,
|
||
Vlacho B,
|
||
Real J,
|
||
Franch-Nadal J,
|
||
Ortega E,
|
||
Mauricio D</span><br />
|
||
<span class="medgenPMjournal">Cardiovasc Diabetol</span>
|
||
2023 Jul 14;22(1):179.
|
||
doi: 10.1186/s12933-023-01917-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37452416" target="_blank">37452416</a><a href="/pmc/articles/PMC10349453" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36359836">Cellular Senescence in Metabolic-Associated Kidney Disease: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gao P,
|
||
Zou X,
|
||
Sun X,
|
||
Zhang C</span><br />
|
||
<span class="medgenPMjournal">Cells</span>
|
||
2022 Oct 31;11(21)
|
||
doi: 10.3390/cells11213443.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36359836" target="_blank">36359836</a><a href="/pmc/articles/PMC9657665" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30419237">Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 2: Air Pollution and Organ Systems.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schraufnagel DE,
|
||
Balmes JR,
|
||
Cowl CT,
|
||
De Matteis S,
|
||
Jung SH,
|
||
Mortimer K,
|
||
Perez-Padilla R,
|
||
Rice MB,
|
||
Riojas-Rodriguez H,
|
||
Sood A,
|
||
Thurston GD,
|
||
To T,
|
||
Vanker A,
|
||
Wuebbles DJ</span><br />
|
||
<span class="medgenPMjournal">Chest</span>
|
||
2019 Feb;155(2):417-426.
|
||
Epub 2018 Nov 9
|
||
doi: 10.1016/j.chest.2018.10.041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30419237" target="_blank">30419237</a><a href="/pmc/articles/PMC6904854" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26475392">Hypertension and Prehypertension and Prediction of Development of Decreased Estimated GFR in the General Population: A Meta-analysis of Cohort Studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garofalo C,
|
||
Borrelli S,
|
||
Pacilio M,
|
||
Minutolo R,
|
||
Chiodini P,
|
||
De Nicola L,
|
||
Conte G</span><br />
|
||
<span class="medgenPMjournal">Am J Kidney Dis</span>
|
||
2016 Jan;67(1):89-97.
|
||
Epub 2015 Oct 23
|
||
doi: 10.1053/j.ajkd.2015.08.027.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26475392" target="_blank">26475392</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20glomerular%20filtration%20rate%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (151)</a></div></div>
|
||
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|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38056996">Prevalence of sarcopenic obesity in patients with diabetes and adverse outcomes: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou YY,
|
||
Wang JF,
|
||
Yao Q,
|
||
Jian QF,
|
||
Luo ZP</span><br />
|
||
<span class="medgenPMjournal">Clin Nutr ESPEN</span>
|
||
2023 Dec;58:128-135.
|
||
Epub 2023 Sep 29
|
||
doi: 10.1016/j.clnesp.2023.09.920.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38056996" target="_blank">38056996</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35099015">Kidney injury rates after unilateral nephrectomy in childhood-a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Groen In 't Woud S,
|
||
Gobino A,
|
||
Roeleveld N,
|
||
van den Heuvel LPWJ,
|
||
Feitz WFJ,
|
||
van der Zanden LFM,
|
||
Schreuder MF</span><br />
|
||
<span class="medgenPMjournal">Nephrol Dial Transplant</span>
|
||
2022 Nov 23;37(12):2457-2473.
|
||
doi: 10.1093/ndt/gfac021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35099015" target="_blank">35099015</a><a href="/pmc/articles/PMC9681928" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33682538">A systematic review and meta-analysis of effects of spironolactone on blood pressure, glucose, lipids, renal function, fibrosis and inflammation in patients with hypertension and diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin M,
|
||
Heizati M,
|
||
Wang L,
|
||
Nurula M,
|
||
Yang Z,
|
||
Wang Z,
|
||
Abudoyreyimu R,
|
||
Wu Z,
|
||
Li N</span><br />
|
||
<span class="medgenPMjournal">Blood Press</span>
|
||
2021 Jun;30(3):145-153.
|
||
Epub 2021 Mar 8
|
||
doi: 10.1080/08037051.2021.1880881.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33682538" target="_blank">33682538</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26997583">Association between prediabetes and risk of chronic kidney disease: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Echouffo-Tcheugui JB,
|
||
Narayan KM,
|
||
Weisman D,
|
||
Golden SH,
|
||
Jaar BG</span><br />
|
||
<span class="medgenPMjournal">Diabet Med</span>
|
||
2016 Dec;33(12):1615-1624.
|
||
Epub 2016 Apr 24
|
||
doi: 10.1111/dme.13113.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26997583" target="_blank">26997583</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26475392">Hypertension and Prehypertension and Prediction of Development of Decreased Estimated GFR in the General Population: A Meta-analysis of Cohort Studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garofalo C,
|
||
Borrelli S,
|
||
Pacilio M,
|
||
Minutolo R,
|
||
Chiodini P,
|
||
De Nicola L,
|
||
Conte G</span><br />
|
||
<span class="medgenPMjournal">Am J Kidney Dis</span>
|
||
2016 Jan;67(1):89-97.
|
||
Epub 2015 Oct 23
|
||
doi: 10.1053/j.ajkd.2015.08.027.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26475392" target="_blank">26475392</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20glomerular%20filtration%20rate%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div></div>
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