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<meta name="keywords" content="C0699885, bladder cancer, bladder carcinoma, cancer of bladder, cancer of the bladder, cancer of the urinary bladder, cancer of urinary bladder, carcinoma bladder, carcinoma of bladder, carcinoma of the bladder, carcinoma of the urinary bladder, carcinoma of urinary bladder, neoplastic process, urinary bladder cancer, urinary bladder carcinoma, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply uncontrollably to form a tumor. The bladder is a muscular organ in the lower abdomen that stores urine until it can be removed (excreted) from the body.\n\nBladder cancer may cause blood in the urine, pain during urination, frequent urination, the feeling of needing to urinate without being able to, or lower back pain. Many of these signs and symptoms are nonspecific, which means they may occur in multiple disorders. People who have one or more of these nonspecific health problems often do not have bladder cancer, but have another condition such as an infection.\n\nBladder cancer develops when tumors form in the tissue that lines the bladder. There are several types of bladder cancer, categorized by the type of cell in the tissue that becomes cancerous. The most common type is transitional cell carcinoma (also known as urothelial carcinoma); others include squamous cell carcinoma and adenocarcinoma. If the tumor spreads (metastasizes) beyond the lining of the bladder into nearby tissues or organs, it is known as invasive bladder cancer. " /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=147071
|
||
ConceptID=C0699885
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Urinary bladder carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>147071</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0699885</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Bladder carcinoma</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Carcinoma of bladder (255108000); Carcinoma of urinary bladder (255108000)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002862">HP:0002862</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0004986" target="_blank">MONDO:0004986</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply uncontrollably to form a tumor. The bladder is a muscular organ in the lower abdomen that stores urine until it can be removed (excreted) from the body.<br /><br />Bladder cancer may cause blood in the urine, pain during urination, frequent urination, the feeling of needing to urinate without being able to, or lower back pain. Many of these signs and symptoms are nonspecific, which means they may occur in multiple disorders. People who have one or more of these nonspecific health problems often do not have bladder cancer, but have another condition such as an infection.<br /><br />Bladder cancer develops when tumors form in the tissue that lines the bladder. There are several types of bladder cancer, categorized by the type of cell in the tissue that becomes cancerous. The most common type is transitional cell carcinoma (also known as urothelial carcinoma); others include squamous cell carcinoma and adenocarcinoma. If the tumor spreads (metastasizes) beyond the lining of the bladder into nearby tissues or organs, it is known as invasive bladder cancer. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0042065[DISCUI]&test_type=Clinical" ref="ncbi_uid=22583">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/22583" ref="tree=GTR&ncbi_uid=22583&link_uid=22583" title="View MedGen record for 'Neoplasm of the genitourinary tract'">Neoplasm of the genitourinary tract</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0474809[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=105374">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/105374" ref="tree=GTR&ncbi_uid=105374&link_uid=105374" title="View MedGen record for 'Endometrioid tumor'">Endometrioid tumor</a></span></li><li class="TLclosed"><span class="TLline"><a href="/medgen/69146" ref="tree=GTR&ncbi_uid=69146&link_uid=69146" title="View MedGen record for 'Kidney angiomyolipoma'">Kidney angiomyolipoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0376358[DISCUI]&test_type=Clinical" ref="ncbi_uid=138169">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=138169" target="_blank" href="/omim/176807">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=138169" ref="ncbi_uid=138169">V</a></span></span><span class="TLline"><a href="/medgen/138169" ref="tree=GTR&ncbi_uid=138169&link_uid=138169" title="View MedGen record for 'Malignant tumor of prostate'">Malignant tumor of prostate</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2931456[DISCUI]&test_type=Clinical" ref="ncbi_uid=419810">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=419810" ref="ncbi_uid=419810">V</a></span></span><span class="TLline"><a href="/medgen/419810" ref="tree=GTR&ncbi_uid=419810&link_uid=419810" title="View MedGen record for 'Familial prostate cancer'">Familial prostate cancer</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0153594[DISCUI]&test_type=Clinical" ref="ncbi_uid=56313">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=56313" ref="ncbi_uid=56313">V</a></span></span><span class="TLline"><a href="/medgen/56313" ref="tree=GTR&ncbi_uid=56313&link_uid=56313" title="View MedGen record for 'Malignant tumor of testis'">Malignant tumor of testis</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1336708[DISCUI]&test_type=Clinical" ref="ncbi_uid=277809">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=277809" target="_blank" href="/omim/273300">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=277809" ref="ncbi_uid=277809">V</a></span></span><span class="TLline"><a href="/medgen/277809" ref="tree=GTR&ncbi_uid=277809&link_uid=277809" title="View MedGen record for 'Germ cell tumor of testis'">Germ cell tumor of testis</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=11371" target="_blank" href="/omim/273300">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/11371" ref="tree=GTR&ncbi_uid=11371&link_uid=11371" title="View MedGen record for 'Seminoma'">Seminoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=68669" target="_blank" href="/omim/273300">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/68669" ref="tree=GTR&ncbi_uid=68669&link_uid=68669" title="View MedGen record for 'Testicular teratoma'">Testicular teratoma</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=102281" target="_blank" href="/omim/191600">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/102281" ref="tree=GTR&ncbi_uid=102281&link_uid=102281" title="View MedGen record for 'Malignant tumor of ureter'">Malignant tumor of ureter</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0005684[DISCUI]&test_type=Clinical" ref="ncbi_uid=14150">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=14150" target="_blank" href="/omim/109800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=14150" ref="ncbi_uid=14150">V</a></span></span><span class="TLline"><a href="/medgen/14150" ref="tree=GTR&ncbi_uid=14150&link_uid=14150" title="View MedGen record for 'Malignant tumor of urinary bladder'">Malignant tumor of urinary bladder</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0699885[DISCUI]&test_type=Clinical" ref="ncbi_uid=147071">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Urinary bladder carcinoma</span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0015558[DISCUI]&test_type=Clinical" ref="ncbi_uid=8775">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/8775" ref="tree=GTR&ncbi_uid=8775&link_uid=8775" title="View MedGen record for 'Neoplasm of fallopian tube'">Neoplasm of fallopian tube</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0042138[DISCUI]&test_type=Clinical" ref="ncbi_uid=12030">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=12030" ref="ncbi_uid=12030">V</a></span></span><span class="TLline"><a href="/medgen/12030" ref="tree=GTR&ncbi_uid=12030&link_uid=12030" title="View MedGen record for 'Neoplasm of uterus'">Neoplasm of uterus</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0014170[DISCUI]&test_type=Clinical" ref="ncbi_uid=8619">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/8619" ref="tree=GTR&ncbi_uid=8619&link_uid=8619" title="View MedGen record for 'Endometrium neoplasm'">Endometrium neoplasm</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007873[DISCUI]&test_type=Clinical" ref="ncbi_uid=40201">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/40201" ref="tree=GTR&ncbi_uid=40201&link_uid=40201" title="View MedGen record for 'Neoplasm of uterine cervix'">Neoplasm of uterine cervix</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/91094" ref="tree=GTR&ncbi_uid=91094&link_uid=91094" title="View MedGen record for 'Oncocytoma of kidney'">Oncocytoma of kidney</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0919267[DISCUI]&test_type=Clinical" ref="ncbi_uid=181539">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=181539" ref="ncbi_uid=181539">V</a></span></span><span class="TLline"><a href="/medgen/181539" ref="tree=GTR&ncbi_uid=181539&link_uid=181539" title="View MedGen record for 'Ovarian neoplasm'">Ovarian neoplasm</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1333992[DISCUI]&test_type=Clinical" ref="ncbi_uid=272713">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=272713" ref="ncbi_uid=272713">V</a></span></span><span class="TLline"><a href="/medgen/272713" ref="tree=GTR&ncbi_uid=272713&link_uid=272713" title="View MedGen record for 'Familial ovarian carcinoma'">Familial ovarian carcinoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1140680[DISCUI]&test_type=Clinical" ref="ncbi_uid=216027">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=216027" target="_blank" href="/omim/167000">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=216027" ref="ncbi_uid=216027">V</a></span></span><span class="TLline"><a href="/medgen/216027" ref="tree=GTR&ncbi_uid=216027&link_uid=216027" title="View MedGen record for 'Ovarian cancer'">Ovarian cancer</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1868358[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=358303">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=358303" target="_blank" href="/omim/171834">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=358303" ref="ncbi_uid=358303">V</a></span></span><span class="TLline"><a href="/medgen/358303" ref="tree=GTR&ncbi_uid=358303&link_uid=358303" title="View MedGen record for 'OVARIAN CANCER, EPITHELIAL, SOMATIC'">OVARIAN CANCER, EPITHELIAL, SOMATIC</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1336839[DISCUI]&test_type=Clinical" ref="ncbi_uid=237026">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=237026" target="_blank" href="/omim/164860">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=237026" ref="ncbi_uid=237026">V</a></span></span><span class="TLline"><a href="/medgen/237026" ref="tree=GTR&ncbi_uid=237026&link_uid=237026" title="View MedGen record for 'Papillary renal cell carcinoma type 1'">Papillary renal cell carcinoma type 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1266142[DISCUI]&test_type=Clinical" ref="ncbi_uid=690113">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/690113" ref="tree=GTR&ncbi_uid=690113&link_uid=690113" title="View MedGen record for 'Renal hamartoma'">Renal hamartoma</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/508335" ref="tree=MeSH" title="MedGen record for Disorder of the genitourinary system">Disorder of the genitourinary system</a></span><ul><li><span class="TLline"><a href="/medgen/21791" ref="tree=MeSH" title="MedGen record for Urinary system disorder">Urinary system disorder</a></span><ul><li><span class="TLline"><a href="/medgen/2278" ref="tree=MeSH" title="MedGen record for Urinary bladder disorder">Urinary bladder disorder</a></span><ul><li><span class="TLline"><a href="/medgen/594" ref="tree=MeSH" title="MedGen record for Bladder neoplasm">Bladder neoplasm</a></span><ul><li><span class="matched_ds">Urinary bladder carcinoma</span><ul><li><span class="TLline"><a href="/medgen/76014" ref="tree=MeSH" title="MedGen record for Bladder adenocarcinoma">Bladder adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/272370" ref="tree=MeSH" title="MedGen record for Bladder clear cell adenocarcinoma">Bladder clear cell adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/267058" ref="tree=MeSH" title="MedGen record for Bladder diffuse clear cell adenocarcinoma">Bladder diffuse clear cell adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/307286" ref="tree=MeSH" title="MedGen record for Bladder papillary clear cell adenocarcinoma">Bladder papillary clear cell adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/267060" ref="tree=MeSH" title="MedGen record for Bladder tubulo-cystic clear cell adenocarcinoma">Bladder tubulo-cystic clear cell adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/267373" ref="tree=MeSH" title="MedGen record for Bladder colloid adenocarcinoma">Bladder colloid adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/267371" ref="tree=MeSH" title="MedGen record for Bladder colonic type adenocarcinoma">Bladder colonic type adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1688315" ref="tree=MeSH" title="MedGen record for Bladder Endometrioid Adenocarcinoma">Bladder Endometrioid Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/267739" ref="tree=MeSH" title="MedGen record for Bladder hepatoid adenocarcinoma">Bladder hepatoid adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/267372" ref="tree=MeSH" title="MedGen record for Bladder mixed adenocarcinoma">Bladder mixed adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/231949" ref="tree=MeSH" title="MedGen record for Bladder signet ring cell adenocarcinoma">Bladder signet ring cell adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/163611" ref="tree=MeSH" title="MedGen record for Recurrent Bladder Adenocarcinoma">Recurrent Bladder Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/208965" ref="tree=MeSH" title="MedGen record for Stage 0 Bladder Adenocarcinoma AJCC v6 and v7">Stage 0 Bladder Adenocarcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/208966" ref="tree=MeSH" title="MedGen record for Stage I Bladder Adenocarcinoma AJCC v6 and v7">Stage I Bladder Adenocarcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/163529" ref="tree=MeSH" title="MedGen record for Stage II Bladder Adenocarcinoma AJCC v6 and v7">Stage II Bladder Adenocarcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/208967" ref="tree=MeSH" title="MedGen record for Stage III Bladder Adenocarcinoma AJCC v6 and v7">Stage III Bladder Adenocarcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/163612" ref="tree=MeSH" title="MedGen record for Stage IV Bladder Adenocarcinoma AJCC v7">Stage IV Bladder Adenocarcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/455797" ref="tree=MeSH" title="MedGen record for Bladder Cancer by AJCC v6 Stage">Bladder Cancer by AJCC v6 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/124516" ref="tree=MeSH" title="MedGen record for Stage 0 Bladder Cancer AJCC v6 and v7">Stage 0 Bladder Cancer AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/233466" ref="tree=MeSH" title="MedGen record for Non-invasive bladder urothelial carcinoma">Non-invasive bladder urothelial carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1663245" ref="tree=MeSH" title="MedGen record for Refractory Stage 0 Bladder Cancer AJCC v6 and v7">Refractory Stage 0 Bladder Cancer AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/163613" ref="tree=MeSH" title="MedGen record for Stage 0 Bladder Squamous Cell Carcinoma AJCC v6 and v7">Stage 0 Bladder Squamous Cell Carcinoma AJCC v6 and v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75875" ref="tree=MeSH" title="MedGen record for Stage I Bladder Cancer AJCC v6 and v7">Stage I Bladder Cancer AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/163685" ref="tree=MeSH" title="MedGen record for Stage I Bladder Cancer with Carcinoma In Situ">Stage I Bladder Cancer with Carcinoma In Situ</a></span></li><li><span class="TLline"><a href="/medgen/167845" ref="tree=MeSH" title="MedGen record for Stage I Bladder Cancer without Carcinoma In Situ">Stage I Bladder Cancer without Carcinoma In Situ</a></span></li><li><span class="TLline"><a href="/medgen/234893" ref="tree=MeSH" title="MedGen record for Stage I Bladder Urothelial Carcinoma AJCC v6 and v7">Stage I Bladder Urothelial Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/208969" ref="tree=MeSH" title="MedGen record for Stage I Squamous Cell Carcinoma of the Bladder AJCC v6 and v7">Stage I Squamous Cell Carcinoma of the Bladder AJCC v6 and v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124518" ref="tree=MeSH" title="MedGen record for Stage II Bladder Cancer AJCC v6 and v7">Stage II Bladder Cancer AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/163614" ref="tree=MeSH" title="MedGen record for Stage II Bladder Squamous Cell Carcinoma AJCC v6 and v7">Stage II Bladder Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/163670" ref="tree=MeSH" title="MedGen record for Stage II Bladder Urothelial Carcinoma AJCC v6 and v7">Stage II Bladder Urothelial Carcinoma AJCC v6 and v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/78889" ref="tree=MeSH" title="MedGen record for Stage III Bladder Cancer AJCC v6 and v7">Stage III Bladder Cancer AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/163615" ref="tree=MeSH" title="MedGen record for Stage III Bladder Squamous Cell Carcinoma AJCC v6 and v7">Stage III Bladder Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/209018" ref="tree=MeSH" title="MedGen record for Stage III Bladder Urothelial Carcinoma AJCC v6 and v7">Stage III Bladder Urothelial Carcinoma AJCC v6 and v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75876" ref="tree=MeSH" title="MedGen record for Stage IV Bladder Cancer AJCC v6">Stage IV Bladder Cancer AJCC v6</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/456295" ref="tree=MeSH" title="MedGen record for Bladder Cancer by AJCC v7 Stage">Bladder Cancer by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/459722" ref="tree=MeSH" title="MedGen record for Stage IV Bladder Cancer AJCC v7">Stage IV Bladder Cancer AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/208970" ref="tree=MeSH" title="MedGen record for Stage IV Bladder Squamous Cell Carcinoma AJCC v7">Stage IV Bladder Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/163671" ref="tree=MeSH" title="MedGen record for Stage IV Bladder Urothelial Carcinoma AJCC v7">Stage IV Bladder Urothelial Carcinoma AJCC v7</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1641451" ref="tree=MeSH" title="MedGen record for Bladder Cancer by AJCC v8 Stage">Bladder Cancer by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1643847" ref="tree=MeSH" title="MedGen record for Stage 0a Bladder Cancer AJCC v8">Stage 0a Bladder Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1633192" ref="tree=MeSH" title="MedGen record for Stage 0is Bladder Cancer AJCC v8">Stage 0is Bladder Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1633229" ref="tree=MeSH" title="MedGen record for Stage I Bladder Cancer AJCC v8">Stage I Bladder Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1636253" ref="tree=MeSH" title="MedGen record for Stage II Bladder Cancer AJCC v8">Stage II Bladder Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1638200" ref="tree=MeSH" title="MedGen record for Stage III Bladder Cancer AJCC v8">Stage III Bladder Cancer AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1635648" ref="tree=MeSH" title="MedGen record for Stage IIIA Bladder Cancer AJCC v8">Stage IIIA Bladder Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1647543" ref="tree=MeSH" title="MedGen record for Stage IIIB Bladder Cancer AJCC v8">Stage IIIB Bladder Cancer AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1635773" ref="tree=MeSH" title="MedGen record for Stage IV Bladder Cancer AJCC v8">Stage IV Bladder Cancer AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1636260" ref="tree=MeSH" title="MedGen record for Stage IVA Bladder Cancer AJCC v8">Stage IVA Bladder Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1634933" ref="tree=MeSH" title="MedGen record for Stage IVB Bladder Cancer AJCC v8">Stage IVB Bladder Cancer AJCC v8</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1676837" ref="tree=MeSH" title="MedGen record for Bladder Neuroendocrine Carcinoma">Bladder Neuroendocrine Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1677587" ref="tree=MeSH" title="MedGen record for Bladder Large Cell Neuroendocrine Carcinoma">Bladder Large Cell Neuroendocrine Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1680278" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Large Cell Neuroendocrine Carcinoma">Metastatic Bladder Large Cell Neuroendocrine Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/231950" ref="tree=MeSH" title="MedGen record for Urinary bladder small cell neuroendocrine carcinoma">Urinary bladder small cell neuroendocrine carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1681176" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Small Cell Neuroendocrine Carcinoma">Metastatic Bladder Small Cell Neuroendocrine Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/124645" ref="tree=MeSH" title="MedGen record for Bladder squamous cell carcinoma">Bladder squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/307289" ref="tree=MeSH" title="MedGen record for Bladder urachal squamous cell carcinoma">Bladder urachal squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/267376" ref="tree=MeSH" title="MedGen record for Bladder verrucous carcinoma">Bladder verrucous carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/311262" ref="tree=MeSH" title="MedGen record for Schistosoma Hematobium-Related Bladder Verrucous Carcinoma">Schistosoma Hematobium-Related Bladder Verrucous Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1676311" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Squamous Cell Carcinoma">Metastatic Bladder Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/208968" ref="tree=MeSH" title="MedGen record for Recurrent Bladder Squamous Cell Carcinoma">Recurrent Bladder Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234773" ref="tree=MeSH" title="MedGen record for Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma">Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/419015" ref="tree=MeSH" title="MedGen record for Bladder urachal carcinoma">Bladder urachal carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/267744" ref="tree=MeSH" title="MedGen record for Bladder urachal urothelial carcinoma">Bladder urachal urothelial carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1712169" ref="tree=MeSH" title="MedGen record for Metastatic Urachal Urothelial Carcinoma">Metastatic Urachal Urothelial Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1699752" ref="tree=MeSH" title="MedGen record for Carcinoma Arising in Bladder Diverticulum">Carcinoma Arising in Bladder Diverticulum</a></span></li><li><span class="TLline"><a href="/medgen/859269" ref="tree=MeSH" title="MedGen record for Childhood bladder carcinoma">Childhood bladder carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1656242" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Carcinoma">Metastatic Bladder Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1718946" ref="tree=MeSH" title="MedGen record for Advanced Bladder Carcinoma">Advanced Bladder Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1720059" ref="tree=MeSH" title="MedGen record for Advanced Bladder Urothelial Carcinoma">Advanced Bladder Urothelial Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1712399" ref="tree=MeSH" title="MedGen record for Locally Advanced Bladder Carcinoma">Locally Advanced Bladder Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1690233" ref="tree=MeSH" title="MedGen record for Locally Advanced Bladder Urothelial Carcinoma">Locally Advanced Bladder Urothelial Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1653371" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Urothelial Carcinoma">Metastatic Bladder Urothelial Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1678134" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma">Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1679881" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Giant Cell Urothelial Carcinoma">Metastatic Bladder Giant Cell Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1674875" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Lipid-Rich Urothelial Carcinoma">Metastatic Bladder Lipid-Rich Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1683732" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Micropapillary Urothelial Carcinoma">Metastatic Bladder Micropapillary Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1674334" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Nested Urothelial Carcinoma">Metastatic Bladder Nested Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1682285" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Plasmacytoid Urothelial Carcinoma">Metastatic Bladder Plasmacytoid Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1675475" ref="tree=MeSH" title="MedGen record for Metastatic Bladder Sarcomatoid Urothelial Carcinoma">Metastatic Bladder Sarcomatoid Urothelial Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/82989" ref="tree=MeSH" title="MedGen record for Recurrent Bladder Carcinoma">Recurrent Bladder Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/923068" ref="tree=MeSH" title="MedGen record for Recurrent Bladder Urothelial Carcinoma">Recurrent Bladder Urothelial Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1737464" ref="tree=MeSH" title="MedGen record for Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma">Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1664919" ref="tree=MeSH" title="MedGen record for Refractory Bladder Carcinoma">Refractory Bladder Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1717591" ref="tree=MeSH" title="MedGen record for Refractory Bladder Urothelial Carcinoma">Refractory Bladder Urothelial Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1792887" ref="tree=MeSH" title="MedGen record for Refractory Non-Muscle Invasive Bladder Urothelial Carcinoma">Refractory Non-Muscle Invasive Bladder Urothelial Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/76013" ref="tree=MeSH" title="MedGen record for Transitional cell carcinoma of the bladder">Transitional cell carcinoma of the bladder</a></span><ul><li><span class="TLline"><a href="/medgen/1781277" ref="tree=MeSH" title="MedGen record for Bladder Flat Urothelial Carcinoma">Bladder Flat Urothelial Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/231947" ref="tree=MeSH" title="MedGen record for Bladder flat intraepithelial lesion">Bladder flat intraepithelial lesion</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/309552" ref="tree=MeSH" title="MedGen record for Bladder papillary urothelial carcinoma">Bladder papillary urothelial carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1684238" ref="tree=MeSH" title="MedGen record for Bladder Non-Invasive Papillary Urothelial Carcinoma">Bladder Non-Invasive Papillary Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/273397" ref="tree=MeSH" title="MedGen record for Micropapillary variant infiltrating bladder urothelial carcinoma">Micropapillary variant infiltrating bladder urothelial carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1792939" ref="tree=MeSH" title="MedGen record for Bladder Urothelial Carcinoma, High Grade">Bladder Urothelial Carcinoma, High Grade</a></span><ul><li><span class="TLline"><a href="/medgen/268191" ref="tree=MeSH" title="MedGen record for Bladder Non-Invasive Papillary Urothelial Carcinoma, High Grade">Bladder Non-Invasive Papillary Urothelial Carcinoma, High Grade</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233582" ref="tree=MeSH" title="MedGen record for Infiltrating bladder urothelial carcinoma">Infiltrating bladder urothelial carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/268571" ref="tree=MeSH" title="MedGen record for Infiltrating bladder lymphoepithelioma-like carcinoma">Infiltrating bladder lymphoepithelioma-like carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/268929" ref="tree=MeSH" title="MedGen record for Infiltrating bladder urothelial carcinoma sarcomatoid variant">Infiltrating bladder urothelial carcinoma sarcomatoid variant</a></span></li><li><span class="TLline"><a href="/medgen/268572" ref="tree=MeSH" title="MedGen record for Infiltrating bladder urothelial carcinoma, clear cell variant">Infiltrating bladder urothelial carcinoma, clear cell variant</a></span></li><li><span class="TLline"><a href="/medgen/307625" ref="tree=MeSH" title="MedGen record for Invasive Bladder Giant Cell Urothelial Carcinoma">Invasive Bladder Giant Cell Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/268270" ref="tree=MeSH" title="MedGen record for Invasive Bladder Urothelial Carcinoma with Glandular Differentiation">Invasive Bladder Urothelial Carcinoma with Glandular Differentiation</a></span></li><li><span class="TLline"><a href="/medgen/268271" ref="tree=MeSH" title="MedGen record for Invasive Bladder Urothelial Carcinoma with Squamous Differentiation">Invasive Bladder Urothelial Carcinoma with Squamous Differentiation</a></span></li><li><span class="TLline"><a href="/medgen/268272" ref="tree=MeSH" title="MedGen record for Invasive Bladder Urothelial Carcinoma with Trophoblastic Differentiation">Invasive Bladder Urothelial Carcinoma with Trophoblastic Differentiation</a></span></li><li><span class="TLline"><a href="/medgen/268928" ref="tree=MeSH" title="MedGen record for Lipid-cell variant infiltrating bladder urothelial carcinoma">Lipid-cell variant infiltrating bladder urothelial carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/268574" ref="tree=MeSH" title="MedGen record for Microcystic variant infiltrating bladder urothelial carcinoma">Microcystic variant infiltrating bladder urothelial carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1792935" ref="tree=MeSH" title="MedGen record for Muscle Invasive Bladder Urothelial Carcinoma">Muscle Invasive Bladder Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/268575" ref="tree=MeSH" title="MedGen record for Nested variant infiltrating bladder urothelial carcinoma">Nested variant infiltrating bladder urothelial carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1773170" ref="tree=MeSH" title="MedGen record for Non-Muscle Invasive Bladder Urothelial Carcinoma">Non-Muscle Invasive Bladder Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/268576" ref="tree=MeSH" title="MedGen record for Plasmacytoid variant infiltrating bladder urothelial carcinoma">Plasmacytoid variant infiltrating bladder urothelial carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234963" ref="tree=MeSH" title="MedGen record for Transplant-Related Bladder Urothelial Carcinoma">Transplant-Related Bladder Urothelial Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1682786" ref="tree=MeSH" title="MedGen record for Unresectable Bladder Urothelial Carcinoma">Unresectable Bladder Urothelial Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1712361" ref="tree=MeSH" title="MedGen record for Unresectable Bladder Carcinoma">Unresectable Bladder Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_82793"><div><strong>Cutis laxa, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82793</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268353</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Occipital horn syndrome (OHS) is a rare connective tissue disorder characterized by hyperelastic and bruisable skin, hernias, bladder diverticula, hyperextensible joints, varicosities, and multiple skeletal abnormalities. The disorder is sometimes accompanied by mild neurologic impairment, and bony abnormalities of the occiput are a common feature, giving rise to the name (summary by Das et al., 1995).</div>
|
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<div class="spaceAbove nowrap">See: <a href="/medgen/82793">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_108454"><div><strong>Costello syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>108454</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0587248</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">While the majority of individuals with HRAS-related Costello syndrome (Costello syndrome) share characteristic findings affecting multiple organ systems, the phenotypic spectrum is wide, ranging from a mild or attenuated phenotype to a severe phenotype with early-lethal complications. Costello syndrome is typically characterized by failure to thrive in infancy as a result of severe postnatal feeding difficulties; short stature; developmental delay or intellectual disability; coarse facial features (full lips, large mouth, full nasal tip); curly or sparse, fine hair; loose, soft skin with deep palmar and plantar creases; papillomata of the face and perianal region; diffuse hypotonia and joint laxity with ulnar deviation of the wrists and fingers; tight Achilles tendons; and cardiac involvement including cardiac hypertrophy (usually hypertrophic cardiomyopathy), congenital heart defects (usually valvular pulmonic stenosis), and arrhythmia (usually supraventricular tachycardia, especially abnormal atrial rhythm / multifocal atrial tachycardia or ectopic atrial tachycardia). Relative or absolute macrocephaly is typical, and postnatal cerebellar overgrowth can result in the development of a Chiari I malformation with associated anomalies including hydrocephalus or syringomyelia. Individuals with Costello syndrome have an approximately 15% lifetime risk for malignant tumors including rhabdomyosarcoma and neuroblastoma in young children and transitional cell carcinoma of the bladder in adolescents and young adults.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/108454">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_108454" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Costello syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82793" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cutis laxa, X-linked</a></div></div>
|
||
</div>
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|
||
<div class="portlet mgSection" id="ID_105">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37470601">Management of surgically inoperable muscle-invasive bladder cancer in a resource constraint setting at a tertiary care center by bladder preservation protocol: Case series.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kumar A,
|
||
Kumar M,
|
||
Semwal MK,
|
||
Singh U,
|
||
Mishra N</span><br />
|
||
<span class="medgenPMjournal">J Cancer Res Ther</span>
|
||
2023 Apr-Jun;19(3):725-730.
|
||
doi: 10.4103/jcrt.jcrt_1661_21.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37470601" target="_blank">37470601</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24576318">Clinical utility of urinary soluble Fas in screening for bladder cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Srivastava AK,
|
||
Singh PK,
|
||
Singh D,
|
||
Dalela D,
|
||
Rath SK,
|
||
Bhatt ML</span><br />
|
||
<span class="medgenPMjournal">Asia Pac J Clin Oncol</span>
|
||
2016 Jun;12(2):e215-21.
|
||
Epub 2014 Feb 27
|
||
doi: 10.1111/ajco.12165.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24576318" target="_blank">24576318</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3528439">Neodymium-YAG laser in the treatment of urinary bladder carcinoma and localized prostatic carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Beisland HO</span><br />
|
||
<span class="medgenPMjournal">J Oslo City Hosp</span>
|
||
1986 Jul-Aug;36(7-8):63-84.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3528439" target="_blank">3528439</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22urinary%20bladder%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (9)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38180342">Mutational signature and prognosis in adenocarcinoma of the bladder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang G,
|
||
Shahatiaili A,
|
||
Bai S,
|
||
Wang L,
|
||
Jin D,
|
||
Cao M,
|
||
Su P,
|
||
Liu Q,
|
||
Tao K,
|
||
Long Q,
|
||
Shi Y,
|
||
Xiao J,
|
||
Tian F,
|
||
Zhang L,
|
||
Chen H,
|
||
Su X</span><br />
|
||
<span class="medgenPMjournal">J Pathol</span>
|
||
2024 Mar;262(3):334-346.
|
||
Epub 2024 Jan 5
|
||
doi: 10.1002/path.6239.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38180342" target="_blank">38180342</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32771229">Distribution of cancer genes in human chromosomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Laderian B,
|
||
Zhou M,
|
||
Fojo T</span><br />
|
||
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<div class="portlet_content ln"><span class="medgenPMauthor">O'Toole C,
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<div class="nl"><a target="_blank" href="/pubmed/37787302">Urinary microRNA-10a levels in diagnosis and prognosis of urinary bladder cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zaidi N,
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Siddiqui Z,
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Sankhwar SN,
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Srivastava AN</span><br />
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Perlmann P,
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Unsgaard B,
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<div class="nl"><a target="_blank" href="/pubmed/38180342">Mutational signature and prognosis in adenocarcinoma of the bladder.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/38180342" target="_blank">38180342</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/27644620">Chronic Infections of the Urinary Tract and Bladder Cancer Risk: a Systematic Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Anderson-Otunu O,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Urinary%20bladder%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (132)</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/34690923">Diabetes Mellitus and Obesity as Risk Factors for Bladder Cancer Prognosis: A Systematic Review and Meta-Analysis.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/27644620">Chronic Infections of the Urinary Tract and Bladder Cancer Risk: a Systematic Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Anderson-Otunu O,
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|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Urinary%20bladder%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0699885%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (16)</a></li>
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<li><a href="/gtr/tests?term=C0699885%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (2)</a></li>
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<li><a href="/gtr/tests?term=C0699885%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (17)</a></li>
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<li><a href="/gtr/tests?term=C0699885%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
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