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<!--
|
||
UID=10147
|
||
ConceptID=C0027022
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Myeloproliferative disorder</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>10147</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0027022</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Myeloproliferative disease</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Myeloproliferative disorder (414794006); Myeloproliferative disorder (425333006); Proliferation of myeloid cells (414794006); Myeloid proliferation (414794006)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005547">HP:0005547</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Proliferation (excess production) of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0027022[DISCUI]&test_type=Clinical" ref="ncbi_uid=10147">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=10147" ref="ncbi_uid=10147">V</a></span></span><span class="TLline">Myeloproliferative disorder</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/208860" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphatic System Disorder">Hematopoietic and Lymphatic System Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/2311" ref="tree=MeSH" title="MedGen record for Bone marrow disorder">Bone marrow disorder</a></span><ul><li><span class="matched_ds">Myeloproliferative disorder</span><ul><li><span class="TLline"><a href="/medgen/45996" ref="tree=MeSH" title="MedGen record for Acquired polycythemia vera">Acquired polycythemia vera</a></span><ul><li><span class="TLline"><a href="/medgen/271322" ref="tree=MeSH" title="MedGen record for Polycythemia Vera, Polycythemic Phase">Polycythemia Vera, Polycythemic Phase</a></span></li><li><span class="TLline"><a href="/medgen/1641083" ref="tree=MeSH" title="MedGen record for Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase">Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/7316" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia, M6 type">Acute myeloid leukemia, M6 type</a></span><ul><li><span class="TLline"><a href="/medgen/79015" ref="tree=MeSH" title="MedGen record for Adult Acute Erythroid Leukemia">Adult Acute Erythroid Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/389533" ref="tree=MeSH" title="MedGen record for Adult Erythroleukemia">Adult Erythroleukemia</a></span></li><li><span class="TLline"><a href="/medgen/417053" ref="tree=MeSH" title="MedGen record for Adult Pure Erythroid Leukemia">Adult Pure Erythroid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232341" ref="tree=MeSH" title="MedGen record for Childhood Acute Erythroid Leukemia">Childhood Acute Erythroid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1614281" ref="tree=MeSH" title="MedGen record for Erythroleukemia">Erythroleukemia</a></span></li><li><span class="TLline"><a href="/medgen/1790819" ref="tree=MeSH" title="MedGen record for Erythroleukemia, familial, susceptibility to">Erythroleukemia, familial, susceptibility to</a></span></li><li><span class="TLline"><a href="/medgen/1626382" ref="tree=MeSH" title="MedGen record for Pure Erythroid Leukemia">Pure Erythroid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1669222" ref="tree=MeSH" title="MedGen record for Recurrent Acute Erythroid Leukemia">Recurrent Acute Erythroid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75993" ref="tree=MeSH" title="MedGen record for Chronic myelogenous leukemia, BCR-ABL1 positive">Chronic myelogenous leukemia, BCR-ABL1 positive</a></span><ul><li><span class="TLline"><a href="/medgen/2281" ref="tree=MeSH" title="MedGen record for Blast phase chronic myelogenous leukemia, BCR-ABL1 positive">Blast phase chronic myelogenous leukemia, BCR-ABL1 positive</a></span></li><li><span class="TLline"><a href="/medgen/6060" ref="tree=MeSH" title="MedGen record for Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive">Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive</a></span></li><li><span class="TLline"><a href="/medgen/6059" ref="tree=MeSH" title="MedGen record for Leukemia, myeloid, accelerated-phase">Leukemia, myeloid, accelerated-phase</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6061" ref="tree=MeSH" title="MedGen record for Chronic neutrophilic leukemia">Chronic neutrophilic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/44129" ref="tree=MeSH" title="MedGen record for Leukemoid reaction">Leukemoid reaction</a></span><ul><li><span class="TLline"><a href="/medgen/760708" ref="tree=MeSH" title="MedGen record for Leukemoid reaction of the newborn">Leukemoid reaction of the newborn</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1529" ref="tree=MeSH" title="MedGen record for Myelophthisic anemia">Myelophthisic anemia</a></span></li><li><span class="TLline"><a href="/medgen/7929" ref="tree=MeSH" title="MedGen record for Primary myelofibrosis">Primary myelofibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/275741" ref="tree=MeSH" title="MedGen record for Cellular phase chronic idiopathic myelofibrosis">Cellular phase chronic idiopathic myelofibrosis</a></span></li><li><span class="TLline"><a href="/medgen/308982" ref="tree=MeSH" title="MedGen record for Overt Primary Myelofibrosis">Overt Primary Myelofibrosis</a></span></li><li><span class="TLline"><a href="/medgen/1791967" ref="tree=MeSH" title="MedGen record for Recurrent Primary Myelofibrosis">Recurrent Primary Myelofibrosis</a></span></li><li><span class="TLline"><a href="/medgen/1740721" ref="tree=MeSH" title="MedGen record for Refractory Primary Myelofibrosis">Refractory Primary Myelofibrosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163397" ref="tree=MeSH" title="MedGen record for Thrombocytosis">Thrombocytosis</a></span><ul><li><span class="TLline"><a href="/medgen/11797" ref="tree=MeSH" title="MedGen record for Essential thrombocythemia">Essential thrombocythemia</a></span><ul><li><span class="TLline"><a href="/medgen/479301" ref="tree=MeSH" title="MedGen record for Thrombocythemia 1">Thrombocythemia 1</a></span></li><li><span class="TLline"><a href="/medgen/477629" ref="tree=MeSH" title="MedGen record for Thrombocythemia 2">Thrombocythemia 2</a></span></li><li><span class="TLline"><a href="/medgen/482755" ref="tree=MeSH" title="MedGen record for Thrombocythemia 3">Thrombocythemia 3</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/929430" ref="tree=MeSH" title="MedGen record for Familial thrombocytosis">Familial thrombocytosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/331782" ref="tree=MeSH" title="MedGen record for Transient myeloproliferative syndrome">Transient myeloproliferative syndrome</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_7929"><div><strong>Primary myelofibrosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7929</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0001815</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Primary myelofibrosis is a condition characterized by the buildup of scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. Because of the fibrosis, the bone marrow is unable to make enough normal blood cells. The shortage of blood cells causes many of the signs and symptoms of primary myelofibrosis.\n\nInitially, most people with primary myelofibrosis have no signs or symptoms. Eventually, fibrosis can lead to a reduction in the number of red blood cells, white blood cells, and platelets. A shortage of red blood cells (anemia) often causes extreme tiredness (fatigue) or shortness of breath. A loss of white blood cells can lead to an increased number of infections, and a reduction of platelets can cause easy bleeding or bruising.\n\nBecause blood cell formation (hematopoiesis) in the bone marrow is disrupted, other organs such as the spleen or liver may begin to produce blood cells. This process, called extramedullary hematopoiesis, often leads to an enlarged spleen (splenomegaly) or an enlarged liver (hepatomegaly). People with splenomegaly may feel pain or fullness in the abdomen, especially below the ribs on the left side. Other common signs and symptoms of primary myelofibrosis include fever, night sweats, and bone pain.\n\nPrimary myelofibrosis is most commonly diagnosed in people aged 50 to 80 but can occur at any age.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/7929">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_4385"><div><strong>Down syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>4385</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0013080</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Down syndrome is a chromosomal condition that is associated with intellectual disability, a characteristic facial appearance, and weak muscle tone (hypotonia) in infancy. All affected individuals experience cognitive delays, but the intellectual disability is usually mild to moderate.\n\nPeople with Down syndrome often have a characteristic facial appearance that includes a flattened appearance to the face, outside corners of the eyes that point upward (upslanting palpebral fissures), small ears, a short neck, and a tongue that tends to stick out of the mouth. Affected individuals may have a variety of birth defects. Many people with Down syndrome have small hands and feet and a single crease across the palms of the hands. About half of all affected children are born with a heart defect. Digestive abnormalities, such as a blockage of the intestine, are less common.\n\nIndividuals with Down syndrome have an increased risk of developing several medical conditions. These include gastroesophageal reflux, which is a backflow of acidic stomach contents into the esophagus, and celiac disease, which is an intolerance of a wheat protein called gluten. About 15 percent of people with Down syndrome have an underactive thyroid gland (hypothyroidism). The thyroid gland is a butterfly-shaped organ in the lower neck that produces hormones. Individuals with Down syndrome also have an increased risk of hearing and vision problems. Additionally, a small percentage of children with Down syndrome develop cancer of blood-forming cells (leukemia).\n\nDelayed development and behavioral problems are often reported in children with Down syndrome. Affected individuals can have growth problems and their speech and language develop later and more slowly than in children without Down syndrome. Additionally, speech may be difficult to understand in individuals with Down syndrome. Behavioral issues can include attention problems, obsessive/compulsive behavior, and stubbornness or tantrums. A small percentage of people with Down syndrome are also diagnosed with developmental conditions called autism spectrum disorders, which affect communication and social interaction.\n\nPeople with Down syndrome often experience a gradual decline in thinking ability (cognition) as they age, usually starting around age 50. Down syndrome is also associated with an increased risk of developing Alzheimer's disease, a brain disorder that results in a gradual loss of memory, judgment, and ability to function. Approximately half of adults with Down syndrome develop Alzheimer's disease. Although Alzheimer's disease is usually a disorder that occurs in older adults, people with Down syndrome commonly develop this condition earlier, in their fifties or sixties.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/4385">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_61525"><div><strong>Idiopathic hypereosinophilic syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>61525</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0206141</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PDGFRA-associated chronic eosinophilic leukemia is a form of blood cell cancer characterized by an elevated number of cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRA-associated chronic eosinophilic leukemia.\n\nAnother characteristic feature of PDGFRA-associated chronic eosinophilic leukemia is organ damage caused by the excess eosinophils. Eosinophils release substances to aid in the immune response, but the release of excessive amounts of these substances causes damage to one or more organs, most commonly the heart, skin, lungs, or nervous system. Eosinophil-associated organ damage can lead to a heart condition known as eosinophilic endomyocardial disease, skin rashes, coughing, difficulty breathing, swelling (edema) in the lower limbs, confusion, changes in behavior, or impaired movement or sensations. People with PDGFRA-associated chronic eosinophilic leukemia can also have an enlarged spleen (splenomegaly) and elevated levels of certain chemicals called vitamin B12 and tryptase in the blood.\n\nSome people with PDGFRA-associated chronic eosinophilic leukemia have an increased number of other types of white blood cells, such as neutrophils or mast cells. Occasionally, people with PDGFRA-associated chronic eosinophilic leukemia develop other blood cell cancers, such as acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.\n\nPDGFRA-associated chronic eosinophilic leukemia is often grouped with a related condition called hypereosinophilic syndrome. These two conditions have very similar signs and symptoms; however, the cause of hypereosinophilic syndrome is unknown.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/61525">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338119"><div><strong>Myeloproliferative disease, autosomal recessive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338119</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1850779</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/338119">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_377060"><div><strong>Myeloproliferative disorder, chronic, with eosinophilia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>377060</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1851585</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PDGFRB-associated chronic eosinophilic leukemia is a type of cancer of blood-forming cells. It is characterized by an elevated number of white blood cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRB-associated chronic eosinophilic leukemia. Some people with this condition have an increased number of other types of white blood cells, such as neutrophils or mast cells, in addition to eosinophils. People with this condition can have an enlarged spleen (splenomegaly) or enlarged liver (hepatomegaly). Some affected individuals develop skin rashes, likely as a result of an abnormal immune response due to the increased number of eosinophils.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/377060">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_4385" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Down syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_61525" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Idiopathic hypereosinophilic syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338119" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Myeloproliferative disease, autosomal recessive</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_377060" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Myeloproliferative disorder, chronic, with eosinophilia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_7929" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary myelofibrosis</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34355465">A neonate diagnosed with Noonan syndrome with myeloproliferative change.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nagatomo K,
|
||
Fukushima H,
|
||
Kanai Y,
|
||
Muramatsu H,
|
||
Takada H</span><br />
|
||
<span class="medgenPMjournal">Pediatr Int</span>
|
||
2021 Dec;63(12):1521-1523.
|
||
Epub 2021 Aug 5
|
||
doi: 10.1111/ped.14634.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34355465" target="_blank">34355465</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32026180">Early diagnosis, clinical management, and follow-up of cardiovascular events with ponatinib.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Casavecchia G,
|
||
Galderisi M,
|
||
Novo G,
|
||
Gravina M,
|
||
Santoro C,
|
||
Agricola E,
|
||
Capalbo S,
|
||
Zicchino S,
|
||
Cameli M,
|
||
De Gennaro L,
|
||
Righini FM,
|
||
Monte I,
|
||
Tocchetti CG,
|
||
Brunetti ND,
|
||
Cadeddu C,
|
||
Mercuro G</span><br />
|
||
<span class="medgenPMjournal">Heart Fail Rev</span>
|
||
2020 May;25(3):447-456.
|
||
doi: 10.1007/s10741-020-09926-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32026180" target="_blank">32026180</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27322988">Diagnosis and treatment of juvenile myelomonocytic leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sakashita K,
|
||
Matsuda K,
|
||
Koike K</span><br />
|
||
<span class="medgenPMjournal">Pediatr Int</span>
|
||
2016 Aug;58(8):681-90.
|
||
doi: 10.1111/ped.13068.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27322988" target="_blank">27322988</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22myeloproliferative%20disorder%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (62)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28052805">Hypereosinophilic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Noh HR,
|
||
Magpantay GG</span><br />
|
||
<span class="medgenPMjournal">Allergy Asthma Proc</span>
|
||
2017 Jan 1;38(1):78-81.
|
||
doi: 10.2500/aap.2017.38.3995.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28052805" target="_blank">28052805</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27590270">Ponatinib in the therapy of chronic myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Poch Martell M,
|
||
Sibai H,
|
||
Deotare U,
|
||
Lipton JH</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2016 Oct;9(10):923-32.
|
||
doi: 10.1080/17474086.2016.1232163.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27590270" target="_blank">27590270</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15690641">Megakaryoblastic disorders in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lorsbach RB</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Pathol</span>
|
||
2004 Dec;122 Suppl:S33-46.
|
||
doi: 10.1309/Y57UGTE36PGQ2NV6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15690641" target="_blank">15690641</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15152961">Polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stuart BJ,
|
||
Viera AJ</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2004 May 1;69(9):2139-44.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15152961" target="_blank">15152961</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9372099">Management of thrombocythemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schafer AI</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Hematol</span>
|
||
1996 Sep;3(5):341-6.
|
||
doi: 10.1097/00062752-199603050-00002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9372099" target="_blank">9372099</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myeloproliferative%20disorder%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (411)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/23350067">Transient myeloproliferative disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moiz B,
|
||
Shafiq M</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2012 Dec 6;120(24):4672.
|
||
doi: 10.1182/blood-2012-07-440917.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23350067" target="_blank">23350067</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22463828">Why does my patient have thrombocytosis?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sulai NH,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2012 Apr;26(2):285-301, viii.
|
||
doi: 10.1016/j.hoc.2012.01.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22463828" target="_blank">22463828</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15690641">Megakaryoblastic disorders in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lorsbach RB</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Pathol</span>
|
||
2004 Dec;122 Suppl:S33-46.
|
||
doi: 10.1309/Y57UGTE36PGQ2NV6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15690641" target="_blank">15690641</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15152961">Polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stuart BJ,
|
||
Viera AJ</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2004 May 1;69(9):2139-44.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15152961" target="_blank">15152961</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9372099">Management of thrombocythemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schafer AI</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Hematol</span>
|
||
1996 Sep;3(5):341-6.
|
||
doi: 10.1097/00062752-199603050-00002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9372099" target="_blank">9372099</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myeloproliferative%20disorder%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (720)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37400251">Outcomes after interruption of targeted therapy in patients with histiocytic neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reiner AS,
|
||
Durham BH,
|
||
Yabe M,
|
||
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|
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<div class="nl"><a target="_blank" href="/pubmed/36252553">JAK: Not Just Another Kinase.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Agashe RP,
|
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Lippman SM,
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<span class="bold">PMID: </span><a href="/pubmed/28673389" target="_blank">28673389</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Crespiatico I,
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<span class="medgenPMjournal">Blood</span>
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2024 Apr 4;143(14):1399-1413.
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doi: 10.1182/blood.2023021349.
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<span class="bold">PMID: </span><a href="/pubmed/38194688" target="_blank">38194688</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30880916">Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Flis S,
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Chojnacki T</span><br />
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<span class="medgenPMjournal">Drug Des Devel Ther</span>
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2019;13:825-843.
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Epub 2019 Mar 8
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doi: 10.2147/DDDT.S191303.
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28673389">Tyrosine Kinase Inhibitor Treatment for Newly Diagnosed Chronic Myeloid Leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Radich JP,
|
||
Mauro MJ</span><br />
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||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2017 Aug;31(4):577-587.
|
||
doi: 10.1016/j.hoc.2017.04.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28673389" target="_blank">28673389</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/28052805">Hypereosinophilic syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Noh HR,
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<span class="medgenPMjournal">Allergy Asthma Proc</span>
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2017 Jan 1;38(1):78-81.
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doi: 10.2500/aap.2017.38.3995.
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<span class="bold">PMID: </span><a href="/pubmed/28052805" target="_blank">28052805</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/23350067">Transient myeloproliferative disorder.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Moiz B,
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2012 Dec 6;120(24):4672.
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doi: 10.1182/blood-2012-07-440917.
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<span class="bold">PMID: </span><a href="/pubmed/23350067" target="_blank">23350067</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myeloproliferative%20disorder%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (425)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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||
<div class="nl"><a target="_blank" href="/pubmed/36252553">JAK: Not Just Another Kinase.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Agashe RP,
|
||
Lippman SM,
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Kurzrock R</span><br />
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<span class="medgenPMjournal">Mol Cancer Ther</span>
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2022 Dec 2;21(12):1757-1764.
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||
doi: 10.1158/1535-7163.MCT-22-0323.
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<span class="bold">PMID: </span><a href="/pubmed/36252553" target="_blank">36252553</a><a href="/pmc/articles/PMC10441554" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/26158763">Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chatterjee A,
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<div class="nl"><a target="_blank" href="/pubmed/22941965">Molecular basis of erythrocyte adhesion to endothelial cells in diseases.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wautier JL,
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<span class="bold">PMID: </span><a href="/pubmed/22941965" target="_blank">22941965</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/18376280">Secondary myelofibrosis in children.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Naithani R,
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Tyagi S,
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Choudhry VP</span><br />
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<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
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2008 Mar;30(3):196-8.
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||
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<span class="bold">PMID: </span><a href="/pubmed/18376280" target="_blank">18376280</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/16210038">Idiopathic myelofibrosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barosi G,
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|
||
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||
<span class="bold">PMID: </span><a href="/pubmed/16210038" target="_blank">16210038</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myeloproliferative%20disorder%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (330)</a></div></div>
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|
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<div class="nl"><a target="_blank" href="/pubmed/38461672">Isolated Rosai-Dorfman disease of the spine: A systematic literature review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Slouma M,
|
||
Bouzid S,
|
||
Tlili K,
|
||
Yedaes D,
|
||
Radhwen K,
|
||
Gharsallah I</span><br />
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||
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
|
||
2024 Apr;239:108206.
|
||
Epub 2024 Feb 29
|
||
doi: 10.1016/j.clineuro.2024.108206.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38461672" target="_blank">38461672</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34794873">Polycythaemia Vera and Coronary Artery Bypass Graft Surgery: A Systematic Review of the Literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Janmohamed IK,
|
||
Sondh RS,
|
||
Ahmed H,
|
||
Afzal MB,
|
||
Tyson N,
|
||
Harky A</span><br />
|
||
<span class="medgenPMjournal">Heart Lung Circ</span>
|
||
2022 Mar;31(3):304-312.
|
||
Epub 2021 Nov 15
|
||
doi: 10.1016/j.hlc.2021.10.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34794873" target="_blank">34794873</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myeloproliferative%20disorder%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0027022%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027022%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027022%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027022%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027022%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027022%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (36)</a></li>
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