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3570 lines
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269 KiB
XML
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<h1 class="res_name"><a href="/gene/">Gene</a></h1>
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<h2 class="res_tagline">Genes and mapped phenotypes</h2>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<input name="EntrezSystem2.PEntrez.Gene.Gene_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
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<div id="faceted_search" class="facet_hide">
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<h2 class="offscreen_noflow">Result Filters</h2>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'5465',linkname:'',idsfromresult:'904',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9f06969195c35ad71e490" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="5465" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<span style="display: block; text-align: center;">S</span>
|
||
<span style="display: block; text-align: center;">I</span>
|
||
<span style="display: block; text-align: center;">D</span>
|
||
<span style="display: block; text-align: center;">E</span>
|
||
<span style="display: block; text-align: center;">B</span>
|
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<span style="display: block; text-align: center;">A</span>
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<span style="display: block; text-align: center;">R</span>
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<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="1" value="full_report" format="" id="full_report" checked="true" /><label for="full_report">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="2" value="full_report" format="text" id="full_reporttext" /><label for="full_reporttext">Full Report (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="3" value="expression" format="" id="expression" /><label for="expression">Expression</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="4" value="gene_table" format="" id="gene_table" /><label for="gene_table">Gene Table</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="5" value="gene_table" format="text" id="gene_tabletext" /><label for="gene_tabletext">Gene Table (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="6" value="generif" format="" id="generif" /><label for="generif">GeneRIF</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="7" value="docsum" format="" id="docsum" /><label for="docsum">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="8" value="docsum" format="text" id="docsumtext" /><label for="docsumtext">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="9" value="tabular" format="" id="tabular" /><label for="tabular">Tabular</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="10" value="tabular" format="text" id="tabulartext" /><label for="tabulartext">Tabular (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="11" value="asn1" format="text" id="asn1text" /><label for="asn1text">ASN.1</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="12" value="xml" format="text" id="xmltext" /><label for="xmltext">XML</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="13" value="uilist" format="text" id="uilisttext" /><label for="uilisttext">UI List</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
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||
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||
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||
var selectedValue = jQuery(this).val().toLowerCase();
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if(selectedDiv.is(":hidden")){
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jQuery("#send_to_menu div.submenu:visible").slideUp();
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selectedDiv.slideDown();
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});
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jQuery("#sendto").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu div.submenu:visible").css("display","none");
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jQuery("#send_to_menu input[type='radio']:checked").attr("checked",false);
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});
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||
|
||
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FFormat" sid="1"><option value="full_report" format="text" selected="selected">Full Report (text)</option><option value="gene_table" format="text">Gene Table (text)</option><option value="docsum" format="text">Summary (text)</option><option value="tabular" format="text">Tabular (text)</option><option value="asn1" format="text">ASN.1</option><option value="xml" format="text">XML</option><option value="uilist" format="text">UI List</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileFormat" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Presentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="rprt full-rprt">
|
||
<div>
|
||
<div class="rprt-header">
|
||
<input type="hidden" id="gene-tax-id" value="9606" />
|
||
<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">CCNT1</span> cyclin T1 [ <em class="tax">Homo sapiens</em> (human)
|
||
]
|
||
</h1>
|
||
<span class="geneid">Gene ID: 904, updated on
|
||
4-Mar-2025</span>
|
||
</div>
|
||
<div class="download-datasets">
|
||
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
|
||
<h4 class="download-datasets-popper jig-ncbipopper" id="download-asm" style="align-self:start" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#download-datasets-popper-menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, groupName: 'entrez_pg', adjustFit:'none'" role="button" aria-expanded="false" aria-haspopup="true">
|
||
<svg alt="download" class="dlbtn-icon" x="0px" y="0px" width="15px" height="15px" viewBox="0 0 60 60" enable-background="new 0 0 60 60" xml:space="preserve">
|
||
<g>
|
||
<polygon points="48.75,36.25 48.75,48.75 11.25,48.75 11.25,36.25 5,36.25 5,55 55,55 55,36.25 "></polygon>
|
||
<polygon points="42.5,23.75 36.25,23.75 36.25,5 23.75,5 23.75,23.75 17.5,23.75 30,42.5 "></polygon>
|
||
</g>
|
||
</svg>
|
||
<a href="#">Download Datasets</a>
|
||
</h4>
|
||
<div id="download-datasets-popper-menu" style="display:none;">
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-gene-seq-fasta" value="FASTA_GENE" checked="checked" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-gene-seq-fasta">Gene Sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-transcript-seq-fasta">Transcript sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
|
||
</div>
|
||
<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
|
||
<div class="input-group">
|
||
<label for="datasets-download-file-name">File name</label>
|
||
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="CCNT1_datasets.zip" />
|
||
</div>
|
||
<input type="hidden" id="download-datasets-base-url" value="https://api.ncbi.nlm.nih.gov/datasets/v2alpha/gene/download" />
|
||
<input type="hidden" id="gene-id-value" value="904" />
|
||
<button id="datasets-download-submit" data-ga-action="click_begin_download" data-ga-label="download" class="jig-ncbibutton ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-gray" role="button">
|
||
<span class="ui-button-text">Download</span>
|
||
</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-body">
|
||
|
||
|
||
<div class="rprt-section gene-summary">
|
||
<section class="rprt-section-header" id="summary">
|
||
<h2 id="header-summary">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Summary</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Summary_2" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div id="summaryDiv" class="section">
|
||
<dl id="summaryDl">
|
||
<dt class="noline"> Official
|
||
Symbol</dt>
|
||
<dd class="noline">CCNT1<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt> Official
|
||
Full Name</dt>
|
||
<dd>cyclin T1<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt>Primary source</dt>
|
||
<dd>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1599" data-gblink-text="Ensembl">HGNC:HGNC:1599</a>
|
||
</dd>
|
||
<dt>See related</dt>
|
||
<dd>
|
||
<a href="http://www.ensembl.org/id/ENSG00000129315" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000129315">Ensembl:ENSG00000129315</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim/143055" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=904&link_uid=143055">MIM:143055;</a>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:1599" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=904&link_uid=HGNC:1599">AllianceGenome:HGNC:1599</a>
|
||
</dd>
|
||
<dt>Gene type</dt>
|
||
<dd>protein coding</dd>
|
||
<dt>RefSeq status</dt>
|
||
<dd>REVIEWED</dd>
|
||
<dt>Organism</dt>
|
||
<dd class="tax">
|
||
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&ncbi_uid=904&link_uid=9606">Homo sapiens</a>
|
||
</dd>
|
||
<dt>Lineage</dt>
|
||
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
|
||
<dt>Also known as</dt>
|
||
<dd>CCNT; CYCT1; HIVE1</dd>
|
||
<dt>Summary</dt>
|
||
<dd>This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]</dd>
|
||
<dt>Expression</dt>
|
||
<dd>Ubiquitous expression in bone marrow (RPKM 11.5), testis (RPKM 9.4) and 25 other tissues <a href="#gene-expression">See more</a></dd>
|
||
<dt>Orthologs</dt>
|
||
<dd class="ortholog-links">
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene/12455">mouse</a>
|
||
<a href="/gene/904/ortholog/">all</a>
|
||
</dd>
|
||
<dt style="padding-top:.5em;">
|
||
<span class="new-icon">NEW</span>
|
||
</dt>
|
||
<dd style="padding-top:.5em;">
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/904/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
|
||
<br />
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/904/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-genomic-context">
|
||
<section class="rprt-section-header" id="genomic-context">
|
||
<h2 id="header-genomic-context">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic context</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Context" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="gc_cont">
|
||
<div class="gt_cont_contents">
|
||
<div style="float:right"><span>See CCNT1 in </span><a href="/genome/gdv/?context=gene&acc=904" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
|
||
<dl class="dl-chr-info" style="float:left;margin-top:0;">
|
||
<dt>Location: </dt>
|
||
<dd>
|
||
<span style="display:inline-block;">12q13.11-q13.12</span>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<dl class="dl-chr-info exon-count">
|
||
<dt>Exon count: </dt>
|
||
<dd>11</dd>
|
||
</dl>
|
||
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="">
|
||
<thead>
|
||
<tr>
|
||
<th style="max-width:15%">Annotation release</th>
|
||
<th style="max-width:10%">Status</th>
|
||
<th>Assembly</th>
|
||
<th>
|
||
<span title="Chromosome">Chr</span>
|
||
</th>
|
||
<th>Location</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=904&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>12</td>
|
||
<td>NC_000012.12 (48688458..48716707, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=904&link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
|
||
<td>12</td>
|
||
<td>NC_060936.1 (48650484..48678733, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=904&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>12</td>
|
||
<td>NC_000012.11 (49082241..49110490, complement) </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<p class="withnote margin_t2em"><strong>Chromosome 12 - NC_000012.12</strong><img usemap="#nbrMap904_568815586" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=904&nuc_gi=568815586&n0=KANSL2&n1=SNORA2A&n2=SNORA2B&n3=LOC130007790&n4=LOC130007791&n5=LOC130007792&n6=CCNT1&n7=LOC129390450&n8=LOC129390451&n9=LOC130007793&n10=LOC127824077&n11=LOC127824078&n12=SPMIP11&n13=LOC130007794&n14=ADCY6&n15=LOC127824079&n16=LOC127824080&n17=MIR4701" /><map name="nbrMap904_568815586" id="nbrMap904_568815586">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'KAT8 regulatory NSL complex subunit 2')" onMouseOut="hidetip()" coords="32,23,140,31" alt="Neighboring gene KAT8 regulatory NSL complex subunit 2" href="/gene/54934" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'small nucleolar RNA, H/ACA box 2A')" onMouseOut="hidetip()" coords="36,35,81,43" alt="Neighboring gene small nucleolar RNA, H/ACA box 2A" href="/gene/677793" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'small nucleolar RNA, H/ACA box 2B')" onMouseOut="hidetip()" coords="64,47,109,55" alt="Neighboring gene small nucleolar RNA, H/ACA box 2B" href="/gene/677794" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 6285')" onMouseOut="hidetip()" coords="77,59,147,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6285" href="/gene/130007790" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 4409')" onMouseOut="hidetip()" coords="78,71,148,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4409" href="/gene/130007791" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 4410')" onMouseOut="hidetip()" coords="79,83,149,91" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4410" href="/gene/130007792" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'MPRA-validated peak1722 silencer')" onMouseOut="hidetip()" coords="124,35,194,43" alt="Neighboring gene MPRA-validated peak1722 silencer" href="/gene/129390450" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'MPRA-validated peak1723 silencer')" onMouseOut="hidetip()" coords="127,47,197,55" alt="Neighboring gene MPRA-validated peak1723 silencer" href="/gene/129390451" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 6286')" onMouseOut="hidetip()" coords="168,23,238,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6286" href="/gene/130007793" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr12:49110605-49111605')" onMouseOut="hidetip()" coords="169,59,239,67" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49110605-49111605" href="/gene/127824077" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr12:49117404-49118078')" onMouseOut="hidetip()" coords="187,71,257,79" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49117404-49118078" href="/gene/127824078" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'sperm microtubule inner protein 11')" onMouseOut="hidetip()" coords="222,35,374,43" alt="Neighboring gene sperm microtubule inner protein 11" href="/gene/255411" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 6288')" onMouseOut="hidetip()" coords="298,23,368,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6288" href="/gene/130007794" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49161309-49161888')" onMouseOut="hidetip()" coords="302,47,372,55" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49161309-49161888" href="/gene/127824079" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49161889-49162469')" onMouseOut="hidetip()" coords="304,59,374,67" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49161889-49162469" href="/gene/127824080" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'adenylate cyclase 6')" onMouseOut="hidetip()" coords="334,71,423,79" alt="Neighboring gene adenylate cyclase 6" href="/gene/112" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'microRNA 4701')" onMouseOut="hidetip()" coords="339,83,384,91" alt="Neighboring gene microRNA 4701" href="/gene/100616262" />
|
||
</map>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-genomic-regions-transcripts-products">
|
||
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
|
||
<h2 id="header-genomic-regions-transcripts-products">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
|
||
</div>
|
||
<div>
|
||
<p class="choose">
|
||
<label for="accession" class="label">Genomic Sequence: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="904">
|
||
<option value="NC_000012.12_48688457_48716706">NC_000012.12 Chromosome 12 Reference GRCh38.p14 Primary Assembly</option>
|
||
<option value="NC_060936.1_48650483_48678732">NC_060936.1 Chromosome 12 Alternate T2T-CHM13v2.0</option>
|
||
<option value="NC_000012.11_49082240_49110489">NC_000012.11 Chromosome 12 Reference GRCh37.p13 Primary Assembly</option>
|
||
</select>
|
||
</p>
|
||
</div>
|
||
<div id="NC_000012" class="divAccession">
|
||
<div class="seq-viewer">
|
||
<p class="note-link">
|
||
<strong>Go to nucleotide:</strong>
|
||
<a title="Nucleotide Graphic report" href="/nuccore/NC_000012.12?report=graph&from=48684220&to=48720943&strand=true&app_context=Gene&assm_context=GCF_000001405.40" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_000012.12">Graphics</a>
|
||
<a title="Nucleotide FASTA report" href="/nuccore/NC_000012.12?report=fasta&from=48688458&to=48716707&strand=true" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_000012.12">FASTA</a>
|
||
<a title="Nucleotide GenBank report" href="/nuccore/NC_000012.12?report=genbank&from=48688458&to=48716707&strand=true" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_000012.12">GenBank</a>
|
||
</p>
|
||
<div id="divNC_000012" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&embedded=true&noslider=1&id=NC_000012.12&from=48684220&to=48720943&strand=true&app_context=Gene&assm_context=GCF_000001405.40">
|
||
<a href="?appname=ncbigene&embedded=true&noslider=1&id=NC_000012.12&from=48684220&to=48720943&strand=true&app_context=Gene&assm_context=GCF_000001405.40"></a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000012.12" sid="1" type="hidden" id="nucleotideLink_NC_000012_12_48688457_48716706" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000012.12?report=graph&amp;from=48684220&amp;to=48720943&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_000012.12">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000012.12?report=fasta&amp;from=48688458&amp;to=48716707&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_000012.12">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000012.12?report=genbank&amp;from=48688458&amp;to=48716707&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_000012.12">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000012.12" sid="1" type="hidden" id="relString_NC_000012_12_48688457_48716706" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000012.12&amp;from=48684220&amp;to=48720943&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060936.1" sid="1" type="hidden" id="nucleotideLink_NC_060936_1_48650483_48678732" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060936.1?report=graph&amp;from=48646246&amp;to=48682969&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_060936.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060936.1?report=fasta&amp;from=48650484&amp;to=48678733&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_060936.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060936.1?report=genbank&amp;from=48650484&amp;to=48678733&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_060936.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060936.1" sid="1" type="hidden" id="relString_NC_060936_1_48650483_48678732" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_060936.1&amp;from=48646246&amp;to=48682969&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000012.11" sid="1" type="hidden" id="nucleotideLink_NC_000012_11_49082240_49110489" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000012.11?report=graph&amp;from=49078003&amp;to=49114726&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_000012.11">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000012.11?report=fasta&amp;from=49082241&amp;to=49110490&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_000012.11">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000012.11?report=genbank&amp;from=49082241&amp;to=49110490&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=904&amp;link_uid=NC_000012.11">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000012.11" sid="1" type="hidden" id="relString_NC_000012_11_49082240_49110489" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000012.11&amp;from=49078003&amp;to=49114726&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-gene-expression">
|
||
<section class="rprt-section-header" id="gene-expression">
|
||
<h2 id="header-gene-expression">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Expression</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">
|
||
<a href="/gene/904/?report=expression" data-url="/gene/904/?report=expression" id="gene-expression-see-details">See details</a>
|
||
</div>
|
||
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/904" data-report-type="summary">
|
||
<div>
|
||
<script type="text/javascript">
|
||
|
||
window.tissues_data = {'adrenal 10wk': {'id': '904_Adrenal_10wk_PRJNA270632', 'gene': 904, 'source_name': 'adrenal 10wk', 'full_rpkm': 6.83771, 'exp_rpkm': 6.84, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495939}, 'adrenal 16wk': {'id': '904_Adrenal_16wk_PRJNA270632', 'gene': 904, 'source_name': 'adrenal 16wk', 'full_rpkm': 5.64111, 'exp_rpkm': 5.64, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495940}, 'adrenal 18wk': {'id': '904_Adrenal_18wk_PRJNA270632', 'gene': 904, 'source_name': 'adrenal 18wk', 'full_rpkm': 6.46492, 'exp_rpkm': 6.46, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495941}, 'adrenal 20wk': {'id': '904_Adrenal_20wk_PRJNA270632', 'gene': 904, 'source_name': 'adrenal 20wk', 'full_rpkm': 5.18992, 'exp_rpkm': 5.19, 'var': 0.517464, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495942}, 'heart 10wk': {'id': '904_Heart_10wk;_PRJNA270632', 'gene': 904, 'source_name': 'heart 10wk', 'full_rpkm': 6.23523, 'exp_rpkm': 6.24, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495943}, 'heart 11wk': {'id': '904_Heart_11wk;_PRJNA270632', 'gene': 904, 'source_name': 'heart 11wk', 'full_rpkm': 4.53608, 'exp_rpkm': 4.54, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495944}, 'heart 17wk': {'id': '904_Heart_17wk;_PRJNA270632', 'gene': 904, 'source_name': 'heart 17wk', 'full_rpkm': 3.60478, 'exp_rpkm': 3.6, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495945}, 'heart 18wk': {'id': '904_Heart_18wk;_PRJNA270632', 'gene': 904, 'source_name': 'heart 18wk', 'full_rpkm': 3.89257, 'exp_rpkm': 3.89, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495946}, 'heart 20wk': {'id': '904_Heart_20wk_PRJNA270632', 'gene': 904, 'source_name': 'heart 20wk', 'full_rpkm': 4.71719, 'exp_rpkm': 4.72, 'var': 0.89325, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495947}, 'intestine 10wk': {'id': '904_Intestine_10wk_PRJNA270632', 'gene': 904, 'source_name': 'intestine 10wk', 'full_rpkm': 5.98759, 'exp_rpkm': 5.99, 'var': 4.07298, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495948}, 'intestine 11wk': {'id': '904_Intestine_11wk_PRJNA270632', 'gene': 904, 'source_name': 'intestine 11wk', 'full_rpkm': 7.36369, 'exp_rpkm': 7.36, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495949}, 'intestine 15wk': {'id': '904_Intestine_15wk_PRJNA270632', 'gene': 904, 'source_name': 'intestine 15wk', 'full_rpkm': 5.3366, 'exp_rpkm': 5.34, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495950}, 'intestine 17wk': {'id': '904_Intestine_17wk_PRJNA270632', 'gene': 904, 'source_name': 'intestine 17wk', 'full_rpkm': 2.4793, 'exp_rpkm': 2.48, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495951}, 'intestine 20wk': {'id': '904_Intestine_20wk_PRJNA270632', 'gene': 904, 'source_name': 'intestine 20wk', 'full_rpkm': 6.49148, 'exp_rpkm': 6.49, 'var': 0.1299276, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495952}, 'kidney 10wk': {'id': '904_Kidney_10wk_PRJNA270632', 'gene': 904, 'source_name': 'kidney 10wk', 'full_rpkm': 6.69747, 'exp_rpkm': 6.7, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495953}, 'kidney 16wk': {'id': '904_Kidney_16wk_PRJNA270632', 'gene': 904, 'source_name': 'kidney 16wk', 'full_rpkm': 3.09587, 'exp_rpkm': 3.1, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495954}, 'kidney 20wk': {'id': '904_Kidney_20wk_PRJNA270632', 'gene': 904, 'source_name': 'kidney 20wk', 'full_rpkm': 1.3848, 'exp_rpkm': 1.38, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495955}, 'lung 10wk': {'id': '904_Lung_10wk_PRJNA270632', 'gene': 904, 'source_name': 'lung 10wk', 'full_rpkm': 5.28756, 'exp_rpkm': 5.29, 'var': 0.1047448, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495956}, 'lung 17wk': {'id': '904_Lung_17wk_PRJNA270632', 'gene': 904, 'source_name': 'lung 17wk', 'full_rpkm': 7.4559, 'exp_rpkm': 7.46, 'var': 0.00756622, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495957}, 'lung 20wk': {'id': '904_Lung_20wk_PRJNA270632', 'gene': 904, 'source_name': 'lung 20wk', 'full_rpkm': 5.48883, 'exp_rpkm': 5.49, 'var': 1.996132, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495958}, 'stomach 10wk': {'id': '904_Stomach_10wk_PRJNA270632', 'gene': 904, 'source_name': 'stomach 10wk', 'full_rpkm': 3.62921, 'exp_rpkm': 3.63, 'var': 0.0985598, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495959}, 'stomach 16wk': {'id': '904_Stomach_16wk_PRJNA270632', 'gene': 904, 'source_name': 'stomach 16wk', 'full_rpkm': 5.64881, 'exp_rpkm': 5.65, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495960}, 'stomach 18wk': {'id': '904_Stomach_18wk_PRJNA270632', 'gene': 904, 'source_name': 'stomach 18wk', 'full_rpkm': 5.6321, 'exp_rpkm': 5.63, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495961}, 'stomach 20wk': {'id': '904_Stomach_20wk_PRJNA270632', 'gene': 904, 'source_name': 'stomach 20wk', 'full_rpkm': 5.07134, 'exp_rpkm': 5.07, 'var': 0.0756612, 'project_desc': 'PRJNA270632', '_version_': 1785734389155495962}};
|
||
|
||
|
||
|
||
|
||
window.details_data = {"adrenal 10wk": [{"id": "metadata_9606_SAMN03267754", "gene": 904, "sample_id": "SAMN03267754", "full_rpkm": 6.83771, "exp_rpkm": 6.84, "exp_total": 237423, "project_desc": "PRJNA270632", "_version_": 1785734387345653765, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 10wk", "exp_Mcount": 4852.92}], "adrenal 16wk": [{"id": "metadata_9606_SAMN03267755", "gene": 904, "sample_id": "SAMN03267755", "full_rpkm": 5.64111, "exp_rpkm": 5.64, "exp_total": 293405, "project_desc": "PRJNA270632", "_version_": 1785734387345653764, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 16wk", "exp_Mcount": 7269.31}], "adrenal 18wk": [{"id": "metadata_9606_SAMN03267761", "gene": 904, "sample_id": "SAMN03267761", "full_rpkm": 6.46492, "exp_rpkm": 6.46, "exp_total": 308781, "project_desc": "PRJNA270632", "_version_": 1785734387345653763, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 18wk", 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5340.16}], "heart 11wk": [{"id": "metadata_9606_SAMN03267763", "gene": 904, "sample_id": "SAMN03267763", "full_rpkm": 4.53608, "exp_rpkm": 4.54, "exp_total": 192692, "project_desc": "PRJNA270632", "_version_": 1785734387344605210, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 11wk", "exp_Mcount": 5937.09}], "heart 17wk": [{"id": "metadata_9606_SAMN03267757", "gene": 904, "sample_id": "SAMN03267757", "full_rpkm": 3.60478, "exp_rpkm": 3.6, "exp_total": 203956, "project_desc": "PRJNA270632", "_version_": 1785734387344605209, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 17wk", "exp_Mcount": 7907.66}], "heart 18wk": [{"id": "metadata_9606_SAMN03267751", "gene": 904, "sample_id": "SAMN03267751", "full_rpkm": 3.89257, "exp_rpkm": 3.89, "exp_total": 177717, "project_desc": "PRJNA270632", "_version_": 1785734387344605208, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 18wk", "exp_Mcount": 6380.91}], "heart 20wk": [{"id": "metadata_9606_SAMN03267756", "gene": 904, "sample_id": "SAMN03267756", "full_rpkm": 3.92958, "exp_rpkm": 3.93, "exp_total": 305241, "project_desc": "PRJNA270632", "_version_": 1785734387344605205, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 10856.4}, {"id": "metadata_9606_SAMN03267764", "gene": 904, "sample_id": "SAMN03267764", "full_rpkm": 6.04621, "exp_rpkm": 6.05, "exp_total": 220524, "project_desc": "PRJNA270632", "_version_": 1785734387344605206, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5097.56}, {"id": "metadata_9606_SAMN03267760", "gene": 904, "sample_id": "SAMN03267760", "full_rpkm": 4.17579, "exp_rpkm": 4.18, "exp_total": 179089, "project_desc": "PRJNA270632", "_version_": 1785734387344605207, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5994.06}], "intestine 10wk": [{"id": "metadata_9606_SAMN03267752", "gene": 904, "sample_id": "SAMN03267752", "full_rpkm": 3.96943, "exp_rpkm": 3.97, "exp_total": 221780, "project_desc": "PRJNA270632", "_version_": 1785734387344605203, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 7808.8}, {"id": "metadata_9606_SAMN03267759", "gene": 904, "sample_id": "SAMN03267759", "full_rpkm": 8.00576, "exp_rpkm": 8.01, "exp_total": 395632, "project_desc": "PRJNA270632", "_version_": 1785734387344605204, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 6906.84}], "intestine 11wk": [{"id": "metadata_9606_SAMN03267758", "gene": 904, "sample_id": "SAMN03267758", "full_rpkm": 7.36369, "exp_rpkm": 7.36, "exp_total": 228394, "project_desc": "PRJNA270632", "_version_": 1785734387344605202, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 11wk", "exp_Mcount": 4334.9}], "intestine 15wk": [{"id": "metadata_9606_SAMN03267775", "gene": 904, "sample_id": "SAMN03267775", "full_rpkm": 5.3366, "exp_rpkm": 5.34, "exp_total": 151987, "project_desc": "PRJNA270632", "_version_": 1785734387344605201, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 15wk", "exp_Mcount": 3980.45}], "intestine 17wk": [{"id": "metadata_9606_SAMN03267782", "gene": 904, "sample_id": "SAMN03267782", "full_rpkm": 2.4793, "exp_rpkm": 2.48, "exp_total": 171463, "project_desc": "PRJNA270632", "_version_": 1785734387344605200, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 17wk", "exp_Mcount": 9665.65}], "intestine 20wk": [{"id": "metadata_9606_SAMN03267766", "gene": 904, "sample_id": "SAMN03267766", "full_rpkm": 6.13103, "exp_rpkm": 6.13, "exp_total": 182544, "project_desc": "PRJNA270632", "_version_": 1785734387344605198, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 4161.26}, {"id": "metadata_9606_SAMN03267769", "gene": 904, "sample_id": "SAMN03267769", "full_rpkm": 6.85194, "exp_rpkm": 6.85, "exp_total": 190906, "project_desc": "PRJNA270632", "_version_": 1785734387344605199, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 3894.01}], "kidney 10wk": [{"id": "metadata_9606_SAMN03267784", "gene": 904, "sample_id": "SAMN03267784", "full_rpkm": 6.69747, "exp_rpkm": 6.7, "exp_total": 226452, "project_desc": "PRJNA270632", "_version_": 1785734387344605197, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 10wk", "exp_Mcount": 4725.59}], "kidney 16wk": [{"id": "metadata_9606_SAMN03267772", "gene": 904, "sample_id": "SAMN03267772", "full_rpkm": 3.09587, "exp_rpkm": 3.1, "exp_total": 338648, "project_desc": "PRJNA270632", "_version_": 1785734387344605196, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 16wk", "exp_Mcount": 15288.2}], "kidney 20wk": [{"id": "metadata_9606_SAMN03267777", "gene": 904, "sample_id": "SAMN03267777", "full_rpkm": 1.3848, "exp_rpkm": 1.38, "exp_total": 101857, "project_desc": "PRJNA270632", "_version_": 1785734387344605195, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 20wk", "exp_Mcount": 10280.0}], "lung 10wk": [{"id": "metadata_9606_SAMN03267770", "gene": 904, "sample_id": "SAMN03267770", "full_rpkm": 5.61121, "exp_rpkm": 5.61, "exp_total": 238992, "project_desc": "PRJNA270632", "_version_": 1785734387344605193, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5952.75}, {"id": "metadata_9606_SAMN03267767", "gene": 904, "sample_id": "SAMN03267767", "full_rpkm": 4.96392, "exp_rpkm": 4.96, "exp_total": 185798, "project_desc": "PRJNA270632", "_version_": 1785734387344605194, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5231.26}], "lung 17wk": [{"id": "metadata_9606_SAMN03267778", "gene": 904, "sample_id": "SAMN03267778", "full_rpkm": 7.36892, "exp_rpkm": 7.37, "exp_total": 329752, "project_desc": "PRJNA270632", "_version_": 1785734387344605191, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 6254.23}, {"id": "metadata_9606_SAMN03267776", "gene": 904, "sample_id": "SAMN03267776", "full_rpkm": 7.54289, "exp_rpkm": 7.54, "exp_total": 202025, "project_desc": "PRJNA270632", "_version_": 1785734387344605192, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 3743.33}], "lung 20wk": [{"id": "metadata_9606_SAMN03267780", "gene": 904, "sample_id": "SAMN03267780", "full_rpkm": 4.07599, "exp_rpkm": 4.08, "exp_total": 270351, "project_desc": "PRJNA270632", "_version_": 1785734387344605189, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 9270.13}, {"id": "metadata_9606_SAMN03267768", "gene": 904, "sample_id": "SAMN03267768", "full_rpkm": 6.90168, "exp_rpkm": 6.9, "exp_total": 313698, "project_desc": "PRJNA270632", "_version_": 1785734387344605190, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 6352.54}], "stomach 10wk": [{"id": "metadata_9606_SAMN03267773", "gene": 904, "sample_id": "SAMN03267773", "full_rpkm": 3.94315, "exp_rpkm": 3.94, "exp_total": 185700, "project_desc": "PRJNA270632", "_version_": 1785734387344605187, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 6582.02}, {"id": "metadata_9606_SAMN03267779", "gene": 904, "sample_id": "SAMN03267779", "full_rpkm": 3.31526, "exp_rpkm": 3.32, "exp_total": 171596, "project_desc": "PRJNA270632", "_version_": 1785734387344605188, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 7234.02}], "stomach 16wk": [{"id": "metadata_9606_SAMN03267774", "gene": 904, "sample_id": "SAMN03267774", "full_rpkm": 5.64881, "exp_rpkm": 5.65, "exp_total": 251372, "project_desc": "PRJNA270632", "_version_": 1785734387344605186, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 16wk", "exp_Mcount": 6219.43}], "stomach 18wk": [{"id": "metadata_9606_SAMN03267771", "gene": 904, "sample_id": "SAMN03267771", "full_rpkm": 5.6321, "exp_rpkm": 5.63, "exp_total": 234549, "project_desc": "PRJNA270632", "_version_": 1785734387344605185, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 18wk", "exp_Mcount": 5820.42}], "stomach 20wk": [{"id": "metadata_9606_SAMN03267765", "gene": 904, "sample_id": "SAMN03267765", "full_rpkm": 5.26057, "exp_rpkm": 5.26, "exp_total": 169173, "project_desc": "PRJNA270632", "_version_": 1785734387342508032, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4494.58}, {"id": "metadata_9606_SAMN03267781", "gene": 904, "sample_id": "SAMN03267781", "full_rpkm": 5.27106, "exp_rpkm": 5.27, "exp_total": 172213, "project_desc": "PRJNA270632", "_version_": 1785734387343556608, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4566.24}, {"id": "metadata_9606_SAMN03267783", "gene": 904, "sample_id": "SAMN03267783", "full_rpkm": 4.68238, "exp_rpkm": 4.68, "exp_total": 160965, "project_desc": "PRJNA270632", "_version_": 1785734387344605184, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4804.58}]}
|
||
window.taxId = 9606
|
||
</script>
|
||
|
||
|
||
<div>
|
||
|
||
|
||
|
||
<select name="p" id="project-selector">
|
||
|
||
|
||
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="SRP056969" data-bioproject="PRJNA280600">
|
||
|
||
RNA sequencing of total RNA from 20 human tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="ERP003613" data-bioproject="PRJEB4337">
|
||
|
||
HPA RNA-seq normal tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
</select>
|
||
|
||
|
||
|
||
<ul id="project-summary">
|
||
<li id="project-summary-title">Project title:
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
|
||
|
||
|
||
|
||
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
|
||
</li>
|
||
|
||
<li id="project-summary-pubs">Publication:
|
||
|
||
|
||
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
<div id="gene-expr-details" class="expression-chart"></div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<script type="text/javascript" src="https://www.gstatic.com/charts/loader.js"></script>
|
||
<script type="text/javascript">
|
||
google.charts.load('current', {
|
||
'packages':[ 'corechart']
|
||
});
|
||
|
||
</script>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-bibliography">
|
||
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
<div class="rprt-section-body" style="">
|
||
<div class="generif-pubmed">
|
||
<h3 id="relatedarticlesinpubmed">
|
||
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
|
||
</h3>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li>
|
||
<a href="/pubmed/39205150/" ref="ordinalpos=1&ncbi_uid=904&link_uid=39205150">A Truncated Isoform of Cyclin T1 Could Contribute to the Non-Permissive HIV-1 Phenotype of U937 Promonocytic Cells.</a>
|
||
<span class="pubmed-auth-date"> Alberio T, <em>et al</em>. Viruses, 2024 Jul 23. PMID 39205150, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC11359826/" ref="ordinalpos=0&ncbi_uid=904&link_uid=PMC11359826">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/11739744/" ref="ordinalpos=2&ncbi_uid=904&link_uid=11739744">Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes.</a>
|
||
<span class="pubmed-auth-date"> Taube R, <em>et al</em>. Mol Cell Biol, 2002 Jan. PMID 11739744, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC134214/" ref="ordinalpos=0&ncbi_uid=904&link_uid=PMC134214">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/30786885/" ref="ordinalpos=3&ncbi_uid=904&link_uid=30786885">Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells.</a>
|
||
<span class="pubmed-auth-date"> Couturier J, <em>et al</em>. Virol J, 2019 Feb 20. PMID 30786885, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC6381639/" ref="ordinalpos=0&ncbi_uid=904&link_uid=PMC6381639">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/32108986/" ref="ordinalpos=4&ncbi_uid=904&link_uid=32108986">Genome-wide association study of word reading: Overlap with risk genes for neurodevelopmental disorders.</a>
|
||
<span class="pubmed-auth-date"> Price KM, <em>et al</em>. Genes Brain Behav, 2020 Jul. PMID 32108986</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/12494448/" ref="ordinalpos=5&ncbi_uid=904&link_uid=12494448">Cyclin T: three forms for different roles in physiological and pathological functions.</a>
|
||
<span class="pubmed-auth-date"> De Luca A, <em>et al</em>. J Cell Physiol, 2003 Feb. PMID 12494448</span>
|
||
</li>
|
||
</ol>
|
||
<p class="see-all-pm">
|
||
<a href="/pubmed?LinkName=gene_pubmed&from_uid=904" title="See all 421 citations in Pubmed">See all (421) citations in PubMed</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="generif-pubmed generif">
|
||
<h3 id="generifsgenereferencesintofunctions">
|
||
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
|
||
</h3>
|
||
<div>
|
||
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/39205150" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=39205150">A Truncated Isoform of Cyclin T1 Could Contribute to the Non-Permissive HIV-1 Phenotype of U937 Promonocytic Cells.</a>
|
||
<div id="gene-popper1" class="gene-rif-popper">Title: A Truncated Isoform of Cyclin T1 Could Contribute to the Non-Permissive HIV-1 Phenotype of U937 Promonocytic Cells.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37766271" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=37766271">A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency.</a>
|
||
<div id="gene-popper2" class="gene-rif-popper">Title: A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/32108986" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=32108986">Genome-wide association study of word reading: Overlap with risk genes for neurodevelopmental disorders.</a>
|
||
<div id="gene-popper3" class="gene-rif-popper">Title: Genome-wide association study of word reading: Overlap with risk genes for neurodevelopmental disorders.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/31603123" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=31603123">CDK9/Cyclin T1 kinase is a protein kinase, indirectly involved in the cell cycle progression.</a>
|
||
<div id="gene-popper4" class="gene-rif-popper">Title: Ligand- and structure-based pharmacophore modeling, docking study reveals 2-[[4-[6-(isopropylamino) pyrimidin-4-yl]-1H-pyrrolo[2,3-b] pyridin-6-yl] amino] ethanol as a potential anticancer agent of CDK9/cyclin T1 kinase.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/30782840" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=30782840">Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97.</a>
|
||
<div id="gene-popper5" class="gene-rif-popper">Title: Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/30786885" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=30786885">CycT1 is most highly upregulated in maximally activated memory CD4 T cells as expected, but may become less associated with T cell activation during HIV replication.</a>
|
||
<div id="gene-popper6" class="gene-rif-popper">Title: Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/28422315" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=28422315">ASF/SF2 is identified as a splicing regulator of cyclin T1, which contributes to the control of the subsequent transcription events.</a>
|
||
<div id="gene-popper7" class="gene-rif-popper">Title: Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-Arginine-Rich Protein ASF/SF2.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/27731797" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=27731797">The TAR central loop contacts the CycT1 Tat-TAR recognition motif (TRM) and the second Tat Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 helix 2 is stabilized in the TAR complex despite not touching the RNA, explaining how it enhances TAR binding to the SEC 50-fold.</a>
|
||
<div id="gene-popper8" class="gene-rif-popper">Title: Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/27193293" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=27193293">Quantitative measurement of the molecular interactions among Tat, CycT1 and CDK9 has showed that any third molecule enhances the binding between the other two molecules. These findings suggest that each component of the Tat:P-TEFb complex stabilizes the overall complex, thereby supporting the efficient transcriptional elongation during viral RNA synthesis.</a>
|
||
<div id="gene-popper9" class="gene-rif-popper">Title: Quantification of the HIV transcriptional activator complex in live cells by image-based protein-protein interaction analysis.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/25909811" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=904&link_uid=25909811">the introduction of HIV-1 Tat and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9/cyclin T1 complex</a>
|
||
<div id="gene-popper10" class="gene-rif-popper">Title: Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study.</div>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<div class="submit-genrif">
|
||
<span>Submit:</span>
|
||
<a href="/gene/submit-generif/?geneId=904&sym=CCNT1&name=cyclin T1&org=Homo sapiens">New GeneRIF</a>
|
||
<a href="/RefSeq/update.cgi?geneid=904&symbol=CCNT1;task=fixpub">Correction</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&report=generif&term=904" class="seeall-generif">See all GeneRIFs (79)</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-phenotypes">
|
||
<section class="rprt-section-header" id="phenotypes">
|
||
<h2 id="header-phenotypes">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body info-phenotype">
|
||
<p class="nochild-link">
|
||
<a href="/gtr/tests/?term=CCNT1[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/gap/PheGenI?tab=1&gene=904">Review eQTL and phenotype association data in this region using PheGenI</a>
|
||
</p>
|
||
<div>
|
||
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
|
||
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
|
||
<thead>
|
||
<tr>
|
||
<th class="description">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/25187353">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/25187353">PubMed</a></span></div></div></div></td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-variation">
|
||
<section class="rprt-section-header" id="variation">
|
||
<h2 id="header-variation">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Variation</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p class="nochild-link">
|
||
<a href="/clinvar/?term=CCNT1[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/dbvar?LinkName=gene_dbvar&from_uid=904" ref="log$=recordlinks">See studies and variants in dbVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=904[geneid]&assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=904[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
|
||
</p>
|
||
<set></set>
|
||
<set></set>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-HIV-1-interactions">
|
||
<section class="rprt-section-header" id="HIV-1-interactions">
|
||
<h2 id="header-HIV-1-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="fgrid">
|
||
<h3 id="replicationinteractions">Replication interactions</h3>
|
||
<table summary="replication interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivinter">HIV transcription is restricted by the dissociation of a functional P-TEFb complex (CCNT1-CDK9) caused by PPP1R10 (PNUTS)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26188041" href="/pubmed/26188041">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 infection increases CCNT1 (Cyclin T1) expression in monocyte derived macrophages</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16330531" href="/pubmed/16330531">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">Knockdown of cyclin T1 (CCNT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18187620" href="/pubmed/18187620">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">Knockdown of cyclin T1 (CCNT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18976975" href="/pubmed/18976975">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<h3 id="proteininteractions">Protein interactions</h3>
|
||
<table summary="protein interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivprotein">Protein</th>
|
||
<th id="gene-hivprotein">Gene</th>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629360">Pr55(Gag)</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">CCNT1 isoform b inhibits HIV-1 RT activity in the media and HIV-1 Gag protein expression in the cell lysate in a dose-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23569210" href="/pubmed/23569210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of CycT1 increases Gag production 20-50 fold in rat T cells. Expression of both CRM1 and CycT1 factors synergistically enhances Gag production to levels approximately 10-40% of those detected in human cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19435492" href="/pubmed/19435492">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629358">Tat</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat binds to CDK9 and CCNT1 (CycT1) in an additive manner as shown through Fluoppi (fluorescent-based technology detecting protein-protein interactions)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27193293" href="/pubmed/27193293">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The N-terminus (amino acids 1-48, including activation domain) of HIV-1 Tat binds to P-TEFb through a direct interaction with the N-terminus (amino acids 1-290) of cyclin T1 during Tat-mediated transactivation of the HIV-1 LTR promoter</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27193293,24217245,22422068,22421880,22355797,22342181,22190034,22100159,21763494,21709748,21035463,20976203,20828615,20471948,20227660,19812265,18931076,18620576,17461970,17289077,12753906,11504720,11080476,10465067,10384302,10364329,10364292,10329125,10077579,9990016,9843510,9832504,9765201,9651670,9491887,9356449,8676484,7853496" href="/pubmed/27193293,24217245,22422068,22421880,22355797,22342181,22190034,22100159,21763494,21709748,21035463,20976203,20828615,20471948,20227660,19812265,18931076,18620576,17461970,17289077,12753906,11504720,11080476,10465067,10384302,10364329,10364292,10329125,10077579,9990016,9843510,9832504,9765201,9651670,9491887,9356449,8676484,7853496">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Cyclin T1 mutant N60A fails to bind to HIV-1 Tat and impairs the effect on Tat-mediated transactivation, but H183A mutant exhibits Tat-binding activity and partially disrupts Tat-mediated transactivation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25781978" href="/pubmed/25781978">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">PKR-mediated Tat phosphorylation inhibits Tat nuclear localization, and disrupts Tat binding to HIV-1 TAR RNA and interaction with cyclin T1 in HeLa cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25653431" href="/pubmed/25653431">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25731772,24793763,24316072,23007159,22567366,22100159,18655042,18483487,18281698" href="/pubmed/25731772,24793763,24316072,23007159,22567366,22100159,18655042,18483487,18281698">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Amino acids Q46, Q50 and F176 of human CycT1 protein are involved in its binding to HIV-1 Tat. A triple-mutant containing Q46A, Q50A and F176A mutations in CycT1 completely abolishes the transcriptional activity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25781978,21763494" href="/pubmed/25781978,21763494">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat recruits P-TEFb to the HIV-1 Transcription Activation Response (TAR) RNA during Tat-mediated transactivation of the HIV-1 LTR promoter</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25731772,23518577,23092279,23087374,23007159,22567366,22355797,22100159,21951552,21709748,21360054,20808803,20724442,20227660,20064163,19812265,19716452,19387490,19211771,17537237,11504720,11455589,10467404,10393900,10384302,10364329,10329125,9843510,9696809,9649438,9491887,8676484" href="/pubmed/25731772,23518577,23092279,23087374,23007159,22567366,22355797,22100159,21951552,21709748,21360054,20808803,20724442,20227660,20064163,19812265,19716452,19387490,19211771,17537237,11504720,11455589,10467404,10393900,10384302,10364329,10329125,9843510,9696809,9649438,9491887,8676484">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">P-TEFb interacts with HIV-1 Tat as part of both the HIV-1 transcription preinitiation and elongation complexes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25735922,25731772,24793763,24565118,24158816,23827503,23754689,23678366,23518577,23330719,23247501,23110726,23092279,23087374,23007159,22692005,22567366,22355797,22342181,22229121,22211660,22100159,21951552,21709748,21360054,21204735,20828615,20808803,20724442,20683478,20571604,20562857,20535204,20471948,20385240,20385237,20227660,20054825,20018238,19716452,19275730,19223581,19020832,18991615,18976462,18281698,18187620,17907378,17625008,17168834,10066804" href="/pubmed/25735922,25731772,24793763,24565118,24158816,23827503,23754689,23678366,23518577,23330719,23247501,23110726,23092279,23087374,23007159,22692005,22567366,22355797,22342181,22229121,22211660,22100159,21951552,21709748,21360054,21204735,20828615,20808803,20724442,20683478,20571604,20562857,20535204,20471948,20385240,20385237,20227660,20054825,20018238,19716452,19275730,19223581,19020832,18991615,18976462,18281698,18187620,17907378,17625008,17168834,10066804">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Cyclin T1 (CCNT1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25496916" href="/pubmed/25496916">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">A homogeneous assay in AlphaLISA indicates that the affinity between HIV-1 Tat and pTEFb is determined to be approximately 20pM, and only 7% of purified Tat is found to be active in forming tertiary complex with pTEFb</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25132562" href="/pubmed/25132562">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Cyclin T1 V107E mutant that exhibits no binding to CDK9 or HEXIM1 has weak interaction with HIV-1 Tat, and inhibits Tat-mediated transactivation in human cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24985467,24985203" href="/pubmed/24985467,24985203">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Cyclin T1 N60K mutant that binds weakly with CDK9, but not with HEXIM1 and AFF4, has weak interaction with HIV-1 Tat and inhibits Tat-mediated transactivation in human cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24985467,24985203" href="/pubmed/24985467,24985203">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Cyclin T1 Y175E and Y175S mutants exhibit no binding to HEXIM1 and HIV-1 Tat, leading to impair Tat-dependent transactivation of HIV LTR</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24985203" href="/pubmed/24985203">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">CDK9-CycT1-AFF1 is stimulated by HIV-1 Tat and transferred as a single complex unit to BRD4 upon stress-induced disruption of AFF1-containing 7SK snRNP (HEMX1, MEPCE, LARP7, 7SK RNA, CDK9, CycT1, and AFF1)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24793763,24367103" href="/pubmed/24793763,24367103">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">AFF1 enhances the affinity of HIV-1 Tat for CycT1, which competitively dissociates HEXIM1 and is responsible for AFF1's promotion of Tat's extraction of CDK9/CycT1 from 7SK snRNP</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24793763,24367103" href="/pubmed/24793763,24367103">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Brd4 inhibits HIV-1 Tat-human super elongation complex (components AFF4, ELL2, CycT1, and CDK9) by competing with HIV-1 Tat for binding to P-TEFb on HIV-1 promoter</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24793763,23658523,23087374" href="/pubmed/24793763,23658523,23087374">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24793763,23087374,21709748,21360054,20683478,20562857" href="/pubmed/24793763,23087374,21709748,21360054,20683478,20562857">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat displaces HEXIM1 from Cyclin T1 in the context of the native 7SK snRNP by interacting with the Cyclin T1-binding domain (amino acid 255-359) of HEXIM1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24793763,23518577,23087374,23007159,22100159,20683478,20562857,17341462" href="/pubmed/24793763,23518577,23087374,23007159,22100159,20683478,20562857,17341462">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The interaction of HIV-1 Tat with HIV-1 Transcription Activation Response (TAR) RNA is enhanced by the interaction of Tat with P-TEFb, and TAR RNA also enhances the interaction between Tat and cyclin T1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24793763,23007159,22100159,21951552,21709748,20064163,19139066,17537237,16838299,16764723,15994812,14972556,11549886,10958691,10944537,10329125,10049833,9651670" href="/pubmed/24793763,23007159,22100159,21951552,21709748,20064163,19139066,17537237,16838299,16764723,15994812,14972556,11549886,10958691,10944537,10329125,10049833,9651670">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">During HIV-1 Tat mediated transactivation of the HIV-1 LTR promoter, Tat stimulates the phosphorylation of the C-terminal domain (CTD) of RNA polymerase II by P-TEFb, leading to transcription elongation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24793763,24359561,24316072,24158816,23827503,23569210,22422068,22355797,22253435,22100159,21951552,21360054,21204735,20828615,20683478,20562857,20471949,20471948,20227660,19812265,19275730,18976462,17907378,14569024,12052871,11547919,11112772,10958691,10866664,10617616,10536359,10438593,10364292,10329125,10082552,10077579,10066804,9696809,9651670,9649438,9570510,8676484,7853496" href="/pubmed/24793763,24359561,24316072,24158816,23827503,23569210,22422068,22355797,22253435,22100159,21951552,21360054,21204735,20828615,20683478,20562857,20471949,20471948,20227660,19812265,19275730,18976462,17907378,14569024,12052871,11547919,11112772,10958691,10866664,10617616,10536359,10438593,10364292,10329125,10082552,10077579,10066804,9696809,9651670,9649438,9570510,8676484,7853496">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">ZASC1, a cellular transcription factor, interacts with HIV-1 Tat and cellular proteins CDK9/Cyclin T1 (P-TEFb) in a TAR-independent manner, suggesting that the Tat/P-TEFb complex in the transcriptional elongation site is promoted by ZASC1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24204263" href="/pubmed/24204263">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Binding of isolated AFF1(1-308) CBS to CDK9/CycT1 prevents HIV-1 Tat from activating HIV transcription and assembling complete SECs (AFF1, AFF4, ELL2, and ENL). The AFF1(1-308) M60A/L61A mutant shows no suppression of Tat transactivation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24367103" href="/pubmed/24367103">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The crystal structure provides a structural basis for the modulation of TAR RNA binding by acetylation of Lys28 in Tat and for involvement of Asn257 in Cyclin T1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24727379" href="/pubmed/24727379">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The crystal structure demonstrates that Met55Thr substitution in AFF4 forms a hydrogen bond with Glu246 of Cyclin T1, which is not as favorable for HIV-1 Tat docking</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24727379" href="/pubmed/24727379">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The Tat-AFF4-P-TEFb complex containing HIV-1 Tat (residues 1-48), human Cyclin T1 (residues 1-266), human Cdk9 (residues 7-332), and human AFF4 (residues 27-69) is determined by the crystal structure analysis</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24727379" href="/pubmed/24727379">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat recruits PPM1G phosphatase protein to dephosphorylate the T loop of CDK9 and release P-TEFb from the 7SK snRNP complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24316072" href="/pubmed/24316072">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24217245" href="/pubmed/24217245">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24367103,23518577,20471949" href="/pubmed/24367103,23518577,20471949">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">A small molecule compound C3 inhibits HIV-1 replication by suppressing HIV-1 Tat-mediated HIV-1 LTR-driven gene expression and phosphorylation of RNAPII through inhibition of Tat binding to CycT1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23274668" href="/pubmed/23274668">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Small molecule ligands disrupt the CDK9/Cyclin T1/Tat complex and dissociate CDK9 away from the HIV-1 transcription complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23247501" href="/pubmed/23247501">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Phosphorylation of CDK9 at position Ser175 regulates the competition between HIV-1 Tat and BRD4 for P-TEFb binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23658523" href="/pubmed/23658523">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Yeast two-hybrid assay shows that CCNT1 isoform b loss the ability of binding to HIV-1 Tat</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23569210" href="/pubmed/23569210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">JQ1, a small molecule inhibitor of Brd4, increases CDK9 T-loop phosphorylation in a Tat-dependent manner and partially dissociates P-TEFb from 7SK snRNP in Jurkat cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23518577,23087374" href="/pubmed/23518577,23087374">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">CCNT1 that lacks exon 7 inhibits HIV-1 replication through the attenuation of HIV-1 Tat/long terminal repeat (LTR)-driven transcription</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23569210,22692005" href="/pubmed/23569210,22692005">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat mutations at positions Y26 and K28 show the most defect in the Tat:TAR:P-TEFb complex formation, but Tat:P-TEFb assembly is not abolished</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23007159" href="/pubmed/23007159">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat mutations at positions P3, P6, W11, K12, T20, T23, V36, I39, T40, and Y47 show decreased Tat activity and P-TEFb assembly/Cdk9 activation, with three residues P3, P6, and W11 possibly involved in Cdk9 interactions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23007159" href="/pubmed/23007159">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Coexpression of RNA-binding domain deficient Tat (T-RS) and two fusion proteins CycT1N-Rev and Cdk9-Rev synergistically stimulates transcription when P-TEFb is tethered to RNA through Rev, and thus T-RS is no longer an inhibitor</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23007159" href="/pubmed/23007159">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">An RNA-binding domain deficient Tat excludes wild-type Tat from the promoter by preferentially assembling with P-TEFb through the Tat activation domain, but can not facilitate transfer of P-TEFb to TAR, thus blocking transition to elongation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23007159" href="/pubmed/23007159">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The P-TEFb binding region (amino acids 1209-1362) of BRD4 is required for HIV-1 Tat-mediated release of P-TEFb from the 7SK snRNP</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23087374,22100159,20808803" href="/pubmed/23087374,22100159,20808803">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat-mediated release of P-TEFb from the 7SK sn RNP results in a conformational change in 7SK RNA and release of HEXIM1 from the complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23007159,22100159,21709748,21360054,20808803" href="/pubmed/23007159,22100159,21709748,21360054,20808803">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">P-TEFb is required for HIV-1 Tat-mediated transcriptional activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23110726,23092279,23087374,23007159,22692005,22567366,22355797,22342181,22100159,21951552,21709748,21360054,20808803,20571604,20064163,20054825,19812265,19387490,19223581,17907378,10913173,10393900,10377393,10082552,9557739,9334326,9334325" href="/pubmed/23110726,23092279,23087374,23007159,22692005,22567366,22355797,22342181,22100159,21951552,21709748,21360054,20808803,20571604,20064163,20054825,19812265,19387490,19223581,17907378,10913173,10393900,10377393,10082552,9557739,9334326,9334325">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat stimulates the phosphorylation of SPT5 by P-TEFb during transactivation of the HIV-1 LTR promoter</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23678366,22100159,21360054,21204735,20571604,20471948,20227660,19275730,18976462,11809800,11112772,10757782" href="/pubmed/23678366,22100159,21360054,21204735,20571604,20471948,20227660,19275730,18976462,11809800,11112772,10757782">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Expression of human cyclin T1 in transgenic mice is sufficient to support HIV-1 Tat-mediated transactivation in primary mouse CD4 T lymphocytes and monocytes/macrophages and increases in vitro and in vivo HIV-1 production</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23170164,16439541" href="/pubmed/23170164,16439541">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Q35L mutant fails to efficiently bind either CDK9 or CycT1 resulting in the defective gene expression. However, the I39Q mutation rescues the Q35L mutant's loss of function</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22253435" href="/pubmed/22253435">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Mutant CycT1-U7, which contains four substitutions and one deletion in the N-terminal cyclin box (67HRFYM71 to IIWE), binds HIV-1 Tat to inhibit HIV transcription. The CycT1-U7 protein fails to interact with Cdk9 or HEXIM1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22342181" href="/pubmed/22342181">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">SKIP is required for Tat transactivation in vivo and stimulates HIV-1 transcription elongation by associating with CycT1:CDK9 (P-TEFb) and Tat:P-TEFb complexes both in nuclear extracts and in recombinant Tat:P-TEFb:TAR RNA complexes in vitro</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,20227660,15905409" href="/pubmed/22100159,20227660,15905409">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat and P-TEFb undergo constant association and dissociation cycles with TAR and the elongating polymerase in living cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,20571604,17537237" href="/pubmed/22100159,20571604,17537237">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Mutant CycT1-U7 shows a potent dominant negative effect on Tat-dependent HIV transcription by specifically targeting Tat into the proteasome degradation pathway</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22342181,18620576" href="/pubmed/22342181,18620576">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat Lys-28 is required for CycT1-dependent RNA binding. Asn 250, but not Asn-257, in the TRM region of CycT1 is important for unacetylated Tat binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,19223581" href="/pubmed/22100159,19223581">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Tat-SF1 is a required cofactor for HIV-1 Tat activity that complexes with P-TEFb and Tat, and stimulates Tat-mediated activation of the HIV-1 LTR promoter</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,11780068,10964778,10913173,10454543,10393184,9765201,9649438,8849451" href="/pubmed/22100159,11780068,10964778,10913173,10454543,10393184,9765201,9649438,8849451">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Hsp70 and Hsp90/Cdc37 stabilize CDK9 as well as the assembly of an active P-TEFb complex which is stimulated by HIV-1 Tat during HIV-1 transcriptional activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,10617616" href="/pubmed/22100159,10617616">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat competes with CIITA for the binding to P-TEFb, leading to the downregulation of MHC class II gene expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22567366,22100159,11118314,10661406" href="/pubmed/22567366,22100159,11118314,10661406">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">MAQ1 and 7SK RNA interact with P-TEFb and compete with the binding of HIV-1 Tat to cyclin T1, suggesting the TAR RNA/Tat lentivirus system evolved to subvert the cellular 7SK RNA/MAQ1 system</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,12832472" href="/pubmed/22100159,12832472">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The p160 nuclear receptor co-activator GRIP1 binds to the N-terminal region of HIV-1 Tat, bridging HIV-1 LTR promoter-bound factors to the Tat-P-TEFb complex and enhancing the transactivating activity of Tat</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,11704662" href="/pubmed/22100159,11704662">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The human I-mfa domain-containing protein (HIC) interacts with both P-TEFb and HIV-1 Tat, and modulates Tat transactivation of the HIV-1 LTR promoter</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,12944466,10671520" href="/pubmed/22100159,12944466,10671520">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Cyclin T1 is capable of recruiting CDK9 and HIV-1 Tat to splicing factor-rich nuclear speckle regions, suggesting nuclear speckles are a site of P-TEFb and Tat function</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,21951552,19223581,17661632,17168834,16838299,15994812,14972556,11282025" href="/pubmed/22100159,21951552,19223581,17661632,17168834,16838299,15994812,14972556,11282025">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The up and downregulation of expression of CDK9 and cyclin T1 or sequestration of cyclin T1 in infected cells may regulate HIV-1 latency by up or downregulating HIV-1 Tat transcriptional activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,21951552,21360054,16838299,16146763,16035254,15719065,15638724,15473004,15183343,15139295,14984439,12727882,12588988,12368300,11739686,11689614,9811724,9356449" href="/pubmed/22100159,21951552,21360054,16838299,16146763,16035254,15719065,15638724,15473004,15183343,15139295,14984439,12727882,12588988,12368300,11739686,11689614,9811724,9356449">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Amino acids 260-263 of cyclin T1 are critical for HIV-1 Tat-mediated transcriptional activation, and mediate the species specificity of cyclin T1 and P-TEFb binding to Tat</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,10364329,10329126,10329125,10077579,9990016,9843510,9832504" href="/pubmed/22100159,10364329,10329126,10329125,10077579,9990016,9843510,9832504">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">P-TEFb regulates HIV-1 Tat-mediated activation of transcription through two built-in auto inhibitory mechanisms, autophosphorylation of CDK9 and cyclin T1 binding to the transcription elongation factor Tat-SF1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,21951552,21360054,19387490,18187620,17907378,17625008,10958691,10913173" href="/pubmed/22100159,21951552,21360054,19387490,18187620,17907378,17625008,10958691,10913173">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Mutant CycT1 protein containing triple T-to-A mutations in the N-terminal region (amino acids T143, T149, and T155) associates with CDK9 and HIV-1 Tat as a kinase-negative complex and blocks HIV transactivation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18931076" href="/pubmed/18931076">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Undetectable CycT1 protein and un-phosphorylation of CDK9 in undifferentiated monocytes result in the lack of Tat transactivation of the LTR promoter in early viral life cycle</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19211771" href="/pubmed/19211771">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">The growth factor granulin and the promyelocytic leukemia (PML) protein regulate HIV-1 Tat-mediated transcriptional activation by competing with the Tat interaction with cyclin T1/P-TEFb</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,12727882,12588988" href="/pubmed/22100159,12727882,12588988">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat-mediated stimulation of RNA polymerase II C-terminal domain phosphorylation by P-TEFb leads to stimulation of co-transcriptional capping of HIV-1 mRNA</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22355797,22100159,21360054,20571604,20471948,20385240,20385237,20227660,19275730,14569024" href="/pubmed/22355797,22100159,21360054,20571604,20471948,20385240,20385237,20227660,19275730,14569024">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Acetylation of HIV-1 Tat by cellular histone acetyltransferases regulates the binding of Tat to P-TEFb</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,21360054,21204735,20828615,20471948,20227660,19812265,19387490,19223581,18187620,12887902,12486002,11080476,10545121" href="/pubmed/22100159,21360054,21204735,20828615,20471948,20227660,19812265,19387490,19223581,18187620,12887902,12486002,11080476,10545121">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of P-TEFb with histone H1 results in its phosphorylation at position Ser-183 in a Tat-dependent manner, which is necessary for transcription from the HIV-1 LTR</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20551309" href="/pubmed/20551309">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">PARP1 negatively regulates HIV-1 transcription by directly competing with Tat-P-TEFb complex for binding to TAR RNA</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,15498776" href="/pubmed/22100159,15498776">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">PRMT6-mediated arginine methylation of HIV-1 Tat negatively affects Tat-TAR-cyclin T1 ternary complex formation and diminishes cyclin T1-dependent Tat transcriptional activation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22100159,17267505" href="/pubmed/22100159,17267505">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Cyclin T1-P-TEFb is important for prostratin stimulation of HIV-1 virus expression in the presence of functional Tat</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17014716" href="/pubmed/17014716">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">IL-10 inhibits HIV-1 gene expression in an HIV-1 Tat-dependent manner by downregulating cyclin T1 expression through the induction of proteasome-mediated proteolysis in human macrophages</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16781761" href="/pubmed/16781761">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16615932" href="/pubmed/16615932">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">P-TEFb, Puralpha and HIV-1 Tat cooperate to activate the TNFalpha promoter</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11730934" href="/pubmed/11730934">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872817">Vpr</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155807">vpr</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpr binds to cyclin T1 (amino acids 300-479) in a ternary complex of HIV-1 Tat, Vpr, Cyclin T1, and CDK9, and enhances Tat transactivation of the viral LTR promoter</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19275586,15142377,10931842" href="/pubmed/19275586,15142377,10931842">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/25121907">reverse transcriptase</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">CCNT1 isoform b inhibits HIV-1 RT activity in the media and HIV-1 Gag protein expression in the cell lysate in a dose-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23569210" href="/pubmed/23569210">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<p class="withnote">
|
||
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-pathways">
|
||
<section class="rprt-section-header" id="pathways">
|
||
<h2 id="header-pathways">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<ul class="geneinfo-subsec infopathway">
|
||
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/904#section=Pathways&embed=true&hide_all_headings=true&page_size=25" style="border: 0; width: 100%;"></iframe>
|
||
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
|
||
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-interactions">
|
||
<section class="rprt-section-header" id="interactions">
|
||
<h2 id="header-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/904/data/interaction/',webserviceParams: 'p$l=Ajax&p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th id="inter-prod">Products</th>
|
||
<th id="inter-interactant">Interactant</th>
|
||
<th id="inter-otherGene">Other Gene</th>
|
||
<th id="inter-compl">Complex</th>
|
||
<th id="inter-source">Source</th>
|
||
<th id="inter-pubs">Pubs</th>
|
||
<th id="inter-desc">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-general-gene-info">
|
||
<section class="rprt-section-header" id="general-gene-info">
|
||
<h2 id="header-general-gene-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General gene information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="gene-markers">
|
||
<h3 id="markers">
|
||
<a class="jig-ncbitoggler">Markers</a>
|
||
</h3>
|
||
<div>
|
||
<ul class="marker odd">
|
||
<li class="marker">STS-H84164 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=46351%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=46351">UniSTS:46351</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH104016 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=98341%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=98341">UniSTS:98341</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">SHGC-33565 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=55887%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=55887">UniSTS:55887</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH17417 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=24937%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=24937">UniSTS:24937</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">SHGC-153516 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=177793%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=177793">UniSTS:177793</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH70421 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=70291%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=70291">UniSTS:70291</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">CCNT1_2415 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=280479%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=280479">UniSTS:280479</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH44408 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=38568%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=38568">UniSTS:38568</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">PMC153984P1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=271280%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=271280">UniSTS:271280</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">CCNT1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=503997%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=503997">UniSTS:503997</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">PMC136632P1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=270800%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=904&link_uid=270800">UniSTS:270800</a></li></ul></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div></div>
|
||
|
||
<div class="infosec">
|
||
<h3 id="homology">
|
||
<a class="jig-ncbitoggler-open">Homology</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>
|
||
<a href="/gene/904/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
|
||
</li>
|
||
<a href="https://www.orthodb.org/?ncbi=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8178" target="_blank">
|
||
Orthologs from OrthoDB
|
||
</a>
|
||
</ul>
|
||
</div>
|
||
|
||
<!--<component id="Gene_InfoPathway"/>-->
|
||
|
||
<div class="infosec info-comment" id="info-comment">
|
||
<h3 id="CloneNames">
|
||
<a class="jig-ncbitoggler-open">Clone Names</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>FLJ11223, DKFZp313A1331, DKFZp313N0919, DKFZp313O1211 </li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="gene-ontology infosec">
|
||
<h3 id="gene-ontology">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Gene Ontology</span>
|
||
</a>
|
||
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
|
||
</h3>
|
||
<div class="ontology-tables">
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Function</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0097322">enables 7SK snRNA binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/11713533" target="_blank" title="PubMed ID 11713533" ref="ordinalpos=1&ncbi_uid=904&link_uid=11713533">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003677">enables DNA binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-2-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/16109376" target="_blank" title="PubMed ID 16109376" ref="ordinalpos=1&ncbi_uid=904&link_uid=16109376">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0140297">enables DNA-binding transcription factor binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-3-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/25116364" target="_blank" title="PubMed ID 25116364" ref="ordinalpos=1&ncbi_uid=904&link_uid=25116364">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0070063">enables RNA polymerase binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-4-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/15563843" target="_blank" title="PubMed ID 15563843" ref="ordinalpos=1&ncbi_uid=904&link_uid=15563843">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003682">enables chromatin binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-5-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0061575">enables cyclin-dependent protein serine/threonine kinase activator activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-6-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0061575">enables cyclin-dependent protein serine/threonine kinase activator activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-7-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/29849146,35393539" target="_blank" title="PubMed ID 29849146,35393539" ref="ordinalpos=1&ncbi_uid=904&link_uid=29849146,35393539">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0140693">enables molecular condensate scaffold activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-8-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/29849146,35393539" target="_blank" title="PubMed ID 29849146,35393539" ref="ordinalpos=1&ncbi_uid=904&link_uid=29849146,35393539">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-9-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9499409,12832472,12944466,15107825,15563843,17289077,17690245,17724342,18281698,18483487,18566585,19387490,19883659,19914168,20153263,20535204,20562857,21220424,21533037,21729782,22190034,22959624,23455922,23602568,24360279,24981860,26659056,28514442,30134174,32707033,33961781,35271311" target="_blank" title="PubMed ID 9499409,12832472,12944466,15107825,15563843,17289077,17690245,17724342,18281698,18483487,18566585,19387490,19883659,19914168,20153263,20535204,20562857,21220424,21533037,21729782,22190034,22959624,23455922,23602568,24360279,24981860,26659056,28514442,30134174,32707033,33961781,35271311" ref="ordinalpos=1&ncbi_uid=904&link_uid=9499409,12832472,12944466,15107825,15563843,17289077,17690245,17724342,18281698,18483487,18566585,19387490,19883659,19914168,20153263,20535204,20562857,21220424,21533037,21729782,22190034,22959624,23455922,23602568,24360279,24981860,26659056,28514442,30134174,32707033,33961781,35271311">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019901">enables protein kinase binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-10-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0000976">enables transcription cis-regulatory region binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-11-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Process</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0051301">involved_in cell division</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-1-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043923">involved_in positive regulation by host of viral transcription</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-2-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10866664" target="_blank" title="PubMed ID 10866664" ref="ordinalpos=1&ncbi_uid=904&link_uid=10866664">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043923">involved_in positive regulation by host of viral transcription</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-3-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/25116364" target="_blank" title="PubMed ID 25116364" ref="ordinalpos=1&ncbi_uid=904&link_uid=25116364">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032786">involved_in positive regulation of DNA-templated transcription, elongation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-4-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045944">involved_in positive regulation of transcription by RNA polymerase II</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-5-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045944">involved_in positive regulation of transcription by RNA polymerase II</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15563843" target="_blank" title="PubMed ID 15563843" ref="ordinalpos=1&ncbi_uid=904&link_uid=15563843">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032968">involved_in positive regulation of transcription elongation by RNA polymerase II</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-7-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9499409,30134174,35393539" target="_blank" title="PubMed ID 9499409,30134174,35393539" ref="ordinalpos=1&ncbi_uid=904&link_uid=9499409,30134174,35393539">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0000079">involved_in regulation of cyclin-dependent protein serine/threonine kinase activity</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-8-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9499409" target="_blank" title="PubMed ID 9499409" ref="ordinalpos=1&ncbi_uid=904&link_uid=9499409">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009410">involved_in response to xenobiotic stimulus</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-9-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006366">involved_in transcription by RNA polymerase II</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-10-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9499409" target="_blank" title="PubMed ID 9499409" ref="ordinalpos=1&ncbi_uid=904&link_uid=9499409">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Component</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0070691">part_of P-TEFb complex</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/18483487,28431135,29849146,30134174" target="_blank" title="PubMed ID 18483487,28431135,29849146,30134174" ref="ordinalpos=1&ncbi_uid=904&link_uid=18483487,28431135,29849146,30134174">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008024">part_of cyclin/CDK positive transcription elongation factor complex</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-2-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008024">part_of cyclin/CDK positive transcription elongation factor complex</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-3-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9499409,15905409" target="_blank" title="PubMed ID 9499409,15905409" ref="ordinalpos=1&ncbi_uid=904&link_uid=9499409,15905409">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008024">part_of cyclin/CDK positive transcription elongation factor complex</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-4-2" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/18566585" target="_blank" title="PubMed ID 18566585" ref="ordinalpos=1&ncbi_uid=904&link_uid=18566585">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-5-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005730">NOT located_in nucleolus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/16109376" target="_blank" title="PubMed ID 16109376" ref="ordinalpos=1&ncbi_uid=904&link_uid=16109376">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005654">located_in nucleoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-7-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005654">located_in nucleoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-8-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">is_active_in nucleus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-9-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">is_active_in nucleus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-10-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/29849146,35393539" target="_blank" title="PubMed ID 29849146,35393539" ref="ordinalpos=1&ncbi_uid=904&link_uid=29849146,35393539">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">located_in nucleus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-11-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12944466,16109376" target="_blank" title="PubMed ID 12944466,16109376" ref="ordinalpos=1&ncbi_uid=904&link_uid=12944466,16109376">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-general-protein-info">
|
||
<section class="rprt-section-header" id="general-protein-info">
|
||
<h2 id="header-general-protein-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General protein information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<dl>
|
||
<dt>Preferred Names</dt>
|
||
<dd>cyclin-T1</dd>
|
||
</dl>
|
||
<dl>
|
||
<dt>Names</dt>
|
||
<dd>CDK9-associated C-type protein</dd>
|
||
<dd>MLLT10/CCNT1 fusion</dd>
|
||
<dd>cyclin C-related protein</dd>
|
||
<dd>human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-reference-sequences">
|
||
<section class="rprt-section-header" id="reference-sequences">
|
||
<h2 id="header-reference-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p>
|
||
<span class="new-icon">NEW</span>
|
||
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&ids=904&utm_source=gene&utm_medium=referral&utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
|
||
</p>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
|
||
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
|
||
Genomes</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
|
||
<p id="refseq-expl"> These reference sequences are curated independently of the genome
|
||
annotation cycle, so their versions may not match the RefSeq versions in the current
|
||
genome build. Identify version mismatches by comparing the version of the RefSeq in
|
||
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
|
||
transcripts, and products</a> above. </p>
|
||
<h4 id="mrnaandproteins-p118913248">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001240.4">NM_001240.4</a> → <a href="/protein/NP_001231.2">NP_001231.2</a> cyclin-T1 isoform a</p>
|
||
<p>
|
||
<a href="/ipg/NP_001231.2/" ref="ncbi_uid=904">See identical proteins and their annotated locations for NP_001231.2</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (a, also known as FL and CycT1a) encodes the longest isoform (a).</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC079951, AF045161, BX098766">AC079951, AF045161, BX098766</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS8766.1">CCDS8766.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/A9XU13" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">A9XU13</a>, <a href="https://www.uniprot.org/uniprot/E7EX76" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">E7EX76</a>, <a href="https://www.uniprot.org/uniprot/O60563" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">O60563</a>, <a href="https://www.uniprot.org/uniprot/O60581" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">O60581</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/A8K4M5" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">A8K4M5</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000261900.3" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">ENSP00000261900.3</a>, <a href="http://www.ensembl.org/id/ENST00000261900.8" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">ENST00000261900.8</a></dd>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001231.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=410298">cd20595</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">10</span> → <span class="cddto">147</span></dt>
|
||
<dd class="clearfix"> CYCLIN_CCNT1_rpt1; first cyclin box found in cyclin-T1 (CCNT1)</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=410300">cd20597</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">151</span> → <span class="cddto">259</span></dt>
|
||
<dd class="clearfix"> CYCLIN_CCNT1_rpt2; second cyclin box found in cyclin-T1 (CCNT1)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001277842.2">NM_001277842.2</a> → <a href="/protein/NP_001264771.1">NP_001264771.1</a> cyclin-T1 isoform b</p>
|
||
<p>
|
||
<a href="/ipg/NP_001264771.1/" ref="ncbi_uid=904">See identical proteins and their annotated locations for NP_001264771.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (b, also known as dE7 and CycT1b) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant a. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a. While this variant may be considered a candidate for nonsense-mediated decay, experimental evidence suggests that it is protein coding (PMID: 23569210 and PMID: 22692005).</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC079951, AK290990, EF688064">AC079951, AK290990, EF688064</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS61109.1">CCDS61109.1</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000481035.1" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">ENSP00000481035.1</a>, <a href="http://www.ensembl.org/id/ENST00000618666.4" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">ENST00000618666.4</a></dd>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001264771.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238003">cd00043</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">38</span> → <span class="cddto">109</span></dt>
|
||
<dd class="clearfix"> CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=333358">cl28538</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1</span> → <span class="cddto">153</span></dt>
|
||
<dd class="clearfix"> CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001413198.1">NM_001413198.1</a> → <a href="/protein/NP_001400127.1">NP_001400127.1</a> cyclin-T1 isoform c</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC079951">AC079951</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/A8K4M5" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">A8K4M5</a>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001413199.1">NM_001413199.1</a> → <a href="/protein/NP_001400128.1">NP_001400128.1</a> cyclin-T1 isoform d</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC079951">AC079951</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/A8K4M5" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">A8K4M5</a>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001413200.1">NM_001413200.1</a> → <a href="/protein/NP_001400129.1">NP_001400129.1</a> cyclin-T1 isoform e</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC079951">AC079951</a>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h4 id="rna-p122506480">RNA</h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/NR_182118.1">NR_182118.1</a> RNA Sequence </p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC079951">AC079951</a>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NR_182119.1">NR_182119.1</a> RNA Sequence </p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC079951">AC079951</a>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
|
||
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following sections contain reference sequences that belong to a
|
||
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
|
||
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
|
||
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
|
||
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
|
||
assemblies. Model RNAs and proteins are also reported here.</p>
|
||
<h3 id="refseq-sequencedescription-p79512016">Reference GRCh38.p14 Primary Assembly</h3>
|
||
<h4 id="genomic-p79512016">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_000012.12 Reference GRCh38.p14 Primary Assembly</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>48688458..48716707 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_000012.12?from=48688458&to=48716707&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_000012.12?from=48688458&to=48716707&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NC_000012.12?from=48688458&to=48716707&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_000012.12?from=48688458&to=48716707&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NC_000012.12?from=48684220&to=48720943&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_000012.12?from=48684220&to=48720943&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h4 id="mrnaandproteins-p69325808">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/XM_017020197.3">XM_017020197.3</a> → <a href="/protein/XP_016875686.1">XP_016875686.1</a> cyclin-T1 isoform X1</p>
|
||
<dl>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/A8K4M5" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">A8K4M5</a>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p54883152">Alternate T2T-CHM13v2.0</h3>
|
||
<h4 id="genomic-p54883152">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_060936.1 Alternate T2T-CHM13v2.0</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>48650484..48678733 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_060936.1?from=48650484&to=48678733&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_060936.1?from=48650484&to=48678733&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NC_060936.1?from=48650484&to=48678733&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_060936.1?from=48650484&to=48678733&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NC_060936.1?from=48646246&to=48682969&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=904&link_uid=NC_060936.1?from=48646246&to=48682969&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h4 id="mrnaandproteins-p83106608">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/XM_054373782.1">XM_054373782.1</a> → <a href="/protein/XP_054229757.1">XP_054229757.1</a> cyclin-T1 isoform X1</p>
|
||
<dl>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/A8K4M5" ref="itool=Gene_FullReport&PrId=5380&uid=904&nlmid=&db=gene">A8K4M5</a>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-related-sequences">
|
||
<section class="rprt-section-header" id="related-sequences">
|
||
<h2 id="header-related-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Related sequences</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/904/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th colspan="2" id="rs-nucleo">Nucleotide</th>
|
||
<th rowspan="2" id="rs-protein">Protein</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-heading">Heading</th>
|
||
<th id="rs-heading-acc">Accession and Version</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
|
||
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-genepept">GenPept Link</th>
|
||
<th id="rs-uniprot">UniProtKB Link</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="rs-prot-acc">O60563.1</td>
|
||
<td headers="rs-link rs-genepept">
|
||
<a href="/protein/9296942" ref="ordinalpos=1&ncbi_uid=904&link_uid=9296942">GenPept</a>
|
||
</td>
|
||
<td>
|
||
<a href="https://www.uniprot.org/uniprot/O60563">UniProtKB/Swiss-Prot:O60563</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-additional-links">
|
||
|
||
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
|
||
|
||
<h3 class="withnote" id="genelinkout">
|
||
<a class="jig-ncbitoggler">Gene LinkOut</a>
|
||
</h3><div>
|
||
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
|
||
<div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Other Literature Sources</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Dryad Digital Repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://datadryad.org/stash/dataset/doi:10.7272/Q6ZP44CR" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7893">
|
||
<span>Dryad Digital Repository</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Chemical Information</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7911">
|
||
<span>Interologous Interaction Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>MilliporeSigma</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/CCNT1?lang=en&region=US" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=9978">
|
||
<span>Ccnt1 products</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Molecular Biology Databases</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Bgee database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000129315" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=10418">
|
||
<span>CCNT1 gene expression</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGPS</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://biogps.org/gene/904/" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=5059">
|
||
<span>BioGPS</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=10164">
|
||
<span>BioGRID CRISPR Screen Phenotypes (53 hits/1381 screens)</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7642">
|
||
<span>CCNT1</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://glygen.org/protein/O60563" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=10227">
|
||
<span>GlyGen glycoinformatics resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Human eFP Browser</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Reproductive&modeInput=Absolute&primaryGene=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&modeInput=Absolute&primaryGene=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&modeInput=Absolute&primaryGene=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>Ingenuity Pathways Analysis</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&p1=Entrez&p2=GV&s=&ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D904%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=5628">
|
||
<span>Ingenuity Pathways Analysis</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InnateDB</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=30254" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7894">
|
||
<span>InnateDB</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InterMine</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000129315" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=9169">
|
||
<span>InterMine</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=5174">
|
||
<span>Kyoto Encyclopedia of Genes and Genomes</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN12340/" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN12338/" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN12339/" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.orthodb.org/?ncbi=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8178">
|
||
<span>Orthologs</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7987">
|
||
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Gene Wiki</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://en.wikipedia.org/wiki/Cyclin_T1" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=6933">
|
||
<span>The Gene Wiki</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Research Materials</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://addgene.org//browse/gene/904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=5304">
|
||
<span>Get Plasmids - Addgene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Bio-Techne</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/cyclin-t1/lysates?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=lysates" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>Cyclin T1 Lysates</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/cyclin-t1/antibodies?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=antibodies" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>Cyclin T1 Antibodies</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/cyclin-t1/proteins-enzymes?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=proteins" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>Cyclin T1 Proteins</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Creative Biogene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.creative-biogene.com/genesearch/CCNT1.html" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=10094">
|
||
<span>cyclin T1</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>ExactAntigen/Labome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/gene/human/CCNT1-antibody.html" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagents</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/review/gene/human/CCNT1-antibody.html" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagent review</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genscript.com/gene/904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8012">
|
||
<span>GenScript latest version of gene cDNA ORF Clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=11&field=5&key=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order shRNA clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=22&field=5&key=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order promoter clone</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&field=5&key=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order full-length ORF clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneTex Inc</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=904&type=01&page=1" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=8117">
|
||
<span>Find Quality Antibodies</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>OriGene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=Ccnt1" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order Ccnt1 cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Tools</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>GeneMANIA</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://genemania.org/link?o=9606&g=904" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=7529">
|
||
<span>GeneMANIA</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Miscellaneous</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Reactome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-1643685" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Disease</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-74160" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Gene expression (Transcription)</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-162582" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Signal Transduction</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:O60563" ref="itool=Gene_FullReport&uid=904&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Entity:O60563</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="urls-in-genombrowser" style="display:none">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div><input type="hidden" class="section_status_input" name="status_checked" id="status_checked" value="" /><input type="hidden" class="section_status_input" name="status_open" id="status_open" value="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_exist" id="status_exist" value="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_closed" id="status_closed" value="" /><meta name="status_checked" content="" class="meta_section_status" /><meta name="status_open" content="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_exist" content="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_closed" content="" class="meta_section_status" /><script type="text/javascript">
|
||
|
||
var section_status_meta = {
|
||
'status_checked': '',
|
||
'status_open': 'summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_exist': 'summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_closed': ''
|
||
};
|
||
|
||
|
||
/*
|
||
for (var o in section_status_meta) {
|
||
var meta=document.createElement('meta');
|
||
meta.name = o;
|
||
meta.content = section_status_meta[o];
|
||
var attr = document.createAttribute('data-ignore-limit');
|
||
attr.value = 'true';
|
||
meta.setAttributeNode(attr);
|
||
document.getElementsByTagName('head')[0].appendChild(meta);
|
||
}
|
||
*/
|
||
|
||
|
||
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
|
||
// data looks like {jsevent: "click", "link_id": "foo", ...}
|
||
// evtObj is the JS event object
|
||
// type is either "stat" (for applog) or "ga"
|
||
var extraData = {};
|
||
if (type == "stat") {
|
||
for (var o in section_status_meta) {
|
||
extraData[o] = section_status_meta[o];
|
||
}
|
||
|
||
return extraData;
|
||
|
||
}
|
||
}
|
||
|
||
|
||
</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last" id="sidebar_tabular">
|
||
<!-- sidebar close/hide button-->
|
||
<div class="ui-helper-clearfix">
|
||
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar >></span></a>
|
||
</div>
|
||
<!-- end sidebar close/hide button-->
|
||
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div id="gene-sidebar">
|
||
<div>
|
||
<div class="portlet brieflink dis-table-of-contents">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Table of contents</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li class="">
|
||
<a href="#summary">Summary</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-context">Genomic context</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#gene-expression">Expression</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#bibliography">Bibliography</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#phenotypes">Phenotypes</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#variation">Variation</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#HIV-1-interactions">HIV-1 interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#pathways">Pathways from PubChem</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#interactions">Interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-gene-info">General gene information</a>
|
||
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#CloneNames">Clone Names</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-protein-info">General protein information</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#related-sequences">Related sequences</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#additional-links">Additional links</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Genome Browsers</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="#">Loading...</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-related-info brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&from_uid=904" ref="log$=recordlinks">3D structures</a>
|
||
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&from_uid=904" ref="log$=recordlinks">BioAssay by Target (List)</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=904" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&from_uid=904" ref="log$=recordlinks">BioAssay, by Gene target</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&from_uid=904" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&from_uid=904" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&from_uid=904" ref="log$=recordlinks">BioProjects</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&from_uid=904" ref="log$=recordlinks">BioSystems</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&DATA=904" ref="log$=recordlinks">CCDS</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&from_uid=904" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&from_uid=904" ref="log$=recordlinks">Conserved Domains</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&from_uid=904" ref="log$=recordlinks">dbVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&from_uid=904" ref="log$=recordlinks">Full text in PMC</a>
|
||
<div class="brieflinkpop offscreen_noflow">PMC links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&from_uid=904" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&from_uid=904" ref="log$=recordlinks">Functional Class</a>
|
||
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&from_uid=904" ref="log$=recordlinks">Gene neighbors</a>
|
||
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&from_uid=904" ref="log$=recordlinks">Genome</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&from_uid=904" ref="log$=recordlinks">GEO Profiles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=904[geneid]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&from_uid=904" ref="log$=recordlinks">HomoloGene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&from_uid=904" ref="log$=recordlinks">Nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&from_uid=904" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&from_uid=904" ref="log$=recordlinks">Probe</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&from_uid=904" ref="log$=recordlinks">Protein</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&from_uid=904" ref="log$=recordlinks">PubChem Compound</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&from_uid=904" ref="log$=recordlinks">PubChem Substance</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&from_uid=904" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&from_uid=904" ref="log$=recordlinks">PubMed (GeneRIF)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&from_uid=904" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&from_uid=904" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&from_uid=904" ref="log$=recordlinks">RefSeq Proteins</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&from_uid=904" ref="log$=recordlinks">RefSeq RNAs</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&from_uid=904" ref="log$=recordlinks">Related gene-specific medical variations</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&from_uid=904" ref="log$=recordlinks">SNP</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&from_uid=904" ref="log$=recordlinks">Taxonomy</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/variation/view/?q=904[geneid]" ref="log$=recordlinks">Variation Viewer</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-links-to-other-res brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Links to other resources</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1599">HGNC</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.ensembl.org/id/ENSG00000129315">Ensembl</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:1599">AllianceGenome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=904">AceView</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_001413198">UCSC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&LIST=BC156506,BC172543">MGC</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:904">KEGG</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://reactome.org/content/query?q=UniProt:O60563">Reactome</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-general-info">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>General information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3840">FAQ</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3841/">Help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3842/">My NCBI help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK21085/">NCBI Handbook</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/statistics/">Statistics</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-related-sites">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related sites</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-feedback">
|
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<div class="portlet_head">
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<div class="portlet_title">
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<h3>Feedback</h3>
|
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</div>
|
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
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<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&deptID=28049">Contact Help Desk</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=904&symbol=CCNT1">Submit Correction</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/submit-generif?geneId=904&sym=CCNT1&name=cyclin T1&org=Homo sapiens">Submit GeneRIF</a>
|
||
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|
||
</ul>
|
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|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
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</div>
|
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<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
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Clear
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
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Turn Off
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Turn On
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|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9f06984f3725e599960ea">CCNT1 cyclin T1 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">CCNT1 cyclin T1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:904</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9f067f4a390645e9b739b">cyclin-T1 isoform a [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">cyclin-T1 isoform a [Homo sapiens]<div class="brieflinkpopdesc">gi|17978466|ref|NP_001231.2|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
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<li class="ra_rcd ralinkpopper two_line">
|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9f05eb15b832ebc6b28ac">CCNH cyclin H [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">CCNH cyclin H [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:902</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
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<li class="ra_rcd ralinkpopper two_line">
|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9f05d84f3725e599912d3">cyclin-H isoform 1 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">cyclin-H isoform 1 [Homo sapiens]<div class="brieflinkpopdesc">gi|4502623|ref|NP_001230.1|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9f057b15b832ebc6b05b0">CCND3 cyclin D3 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">CCND3 cyclin D3 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:896</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
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</ul>
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<p class="HTOn">Your browsing activity is empty.</p>
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<p id="turnOn" class="HTOff">
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
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</p>
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<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
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