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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'3828',linkname:'',idsfromresult:'4773',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9e28e69195c35ad6e549b" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="3828" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">NFATC2</span> nuclear factor of activated T cells 2 [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 4773, updated on
4-Mar-2025</span>
</div>
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<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">NFATC2<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>nuclear factor of activated T cells 2<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7776" data-gblink-text="Ensembl">HGNC:HGNC:7776</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000101096" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000101096">Ensembl:ENSG00000101096</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/600490" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=600490">MIM:600490;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:7776" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=HGNC:7776">AllianceGenome:HGNC:7776</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>JCOSL; NFAT1; NFATP</dd>
<dt>Summary</dt>
<dd>This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]</dd>
<dt>Expression</dt>
<dd>Broad expression in gall bladder (RPKM 9.1), lymph node (RPKM 6.9) and 25 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="https://www.ncbi.nlm.nih.gov/gene/18019">mouse</a>
<a href="/gene/4773/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/4773/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/4773/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
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<div class="rprt-section gene-genomic-context">
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<div class="gc_cont">
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<div style="float:right"><span>See NFATC2 in </span><a href="/genome/gdv/?context=gene&amp;acc=4773" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">20q13.2</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>13</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=4773&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>20</td>
<td>NC_000020.11 (51386963..51562839, complement) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=4773&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>20</td>
<td>NC_060944.1 (53157543..53333581, complement) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=4773&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>20</td>
<td>NC_000020.10 (50003500..50179378, complement) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 20 - NC_000020.11</strong><img usemap="#nbrMap4773_568815578" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=4773&amp;nuc_gi=568815578&amp;n0=LOC105372661&amp;n1=RPSAP1&amp;n2=LOC130066168&amp;n3=LOC130066169&amp;n4=LOC127893712&amp;n5=LOC127893713&amp;n6=LOC127893714&amp;n7=LOC126863049&amp;n8=LOC127893715&amp;n9=LOC127893716&amp;n10=LOC127893717&amp;n11=LOC127893718&amp;n12=LOC127893719&amp;n13=LOC124904930&amp;n14=LOC121627910&amp;n15=LOC105372663&amp;n16=NFATC2&amp;n17=LOC130066170&amp;n18=LOC130066171&amp;n19=LOC125387298&amp;n20=LOC127893720&amp;n21=LOC127893721&amp;n22=LOC130066172&amp;n23=LOC126863050&amp;n24=LOC121627911&amp;n25=LOC127893722&amp;n26=MIR3194&amp;n27=LOC127893723&amp;n28=LOC127893724&amp;n29=LOC126863051&amp;n30=LOC127882580&amp;n31=LOC130066173&amp;n32=LOC130066174&amp;n33=LOC130066175&amp;n34=LOC126863052&amp;n35=LOC127893725&amp;n36=LOC130066176&amp;n37=LOC130066177&amp;n38=LOC127893726&amp;n39=ATP9A&amp;n40=LOC126863053&amp;n41=LOC129664650&amp;n42=LOC127893727&amp;n43=LOC126863054&amp;n44=LOC121853013&amp;n45=LOC125387299&amp;n46=LOC127893728&amp;n47=LOC125387300&amp;n48=LOC127893729&amp;n49=LOC127893730&amp;n50=LOC127893731&amp;n51=LOC127893732&amp;n52=LOC127893733&amp;n53=RPL29P35&amp;n54=LOC125387301&amp;n55=LOC125387302&amp;n56=LOC127893734&amp;n57=LOC127893735&amp;n58=SALL4&amp;n59=LOC127893736&amp;n60=LOC127893737&amp;n61=LOC127893738&amp;n62=LOC127893739&amp;n63=LOC127893740&amp;n64=LOC127893741&amp;n65=LOC130066178&amp;n66=LOC127893742&amp;n67=LOC127893743" /><map name="nbrMap4773_568815578" id="nbrMap4773_568815578">
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105372661')" onMouseOut="hidetip()" coords="2,23,77,31" alt="Neighboring gene uncharacterized LOC105372661" href="/gene/105372661" />
<area shape="rect" onMouseOver="showtip(this,event,'ribosomal protein SA pseudogene 1')" onMouseOut="hidetip()" coords="39,35,79,43" alt="Neighboring gene ribosomal protein SA pseudogene 1" href="/gene/170529" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 13040')" onMouseOut="hidetip()" coords="56,47,126,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13040" href="/gene/130066169" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 13039')" onMouseOut="hidetip()" coords="56,59,126,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13039" href="/gene/130066168" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49838165-49838839')" onMouseOut="hidetip()" coords="57,71,127,79" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49838165-49838839" href="/gene/127893712" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49838840-49839513')" onMouseOut="hidetip()" coords="57,83,127,91" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49838840-49839513" href="/gene/127893713" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49853584-49854170')" onMouseOut="hidetip()" coords="65,95,135,103" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49853584-49854170" href="/gene/127893714" />
<area shape="rect" onMouseOver="showtip(this,event,'BRD4-independent group 4 enhancer GRCh37_chr20:49874837-49876036')" onMouseOut="hidetip()" coords="76,107,146,115" alt="Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:49874837-49876036" href="/gene/126863049" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49922777-49923737')" onMouseOut="hidetip()" coords="101,23,171,31" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49922777-49923737" href="/gene/127893715" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:49927461-49928450')" onMouseOut="hidetip()" coords="103,35,173,43" alt="Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:49927461-49928450" href="/gene/127893716" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:49928451-49929439')" onMouseOut="hidetip()" coords="104,119,174,127" alt="Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:49928451-49929439" href="/gene/127893717" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:49938175-49938676')" onMouseOut="hidetip()" coords="109,131,179,139" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49938175-49938676" href="/gene/127893718" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:49944615-49945493')" onMouseOut="hidetip()" coords="112,143,182,151" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49944615-49945493" href="/gene/127893719" />
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC124904930')" onMouseOut="hidetip()" coords="122,155,192,163" alt="Neighboring gene uncharacterized LOC124904930" href="/gene/124904930" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 14118')" onMouseOut="hidetip()" coords="132,47,202,55" alt="Neighboring gene Sharpr-MPRA regulatory region 14118" href="/gene/121627910" />
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105372663')" onMouseOut="hidetip()" coords="132,59,210,67" alt="Neighboring gene uncharacterized LOC105372663" href="/gene/105372663" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18109')" onMouseOut="hidetip()" coords="150,71,220,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18109" href="/gene/130066170" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18110')" onMouseOut="hidetip()" coords="153,83,223,91" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18110" href="/gene/130066171" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 9422')" onMouseOut="hidetip()" coords="160,95,230,103" alt="Neighboring gene Sharpr-MPRA regulatory region 9422" href="/gene/125387298" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:50039818-50040650')" onMouseOut="hidetip()" coords="162,107,232,115" alt="Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:50039818-50040650" href="/gene/127893720" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50041537-50042129')" onMouseOut="hidetip()" coords="163,167,233,175" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50041537-50042129" href="/gene/127893721" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18111')" onMouseOut="hidetip()" coords="163,179,233,187" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18111" href="/gene/130066172" />
<area shape="rect" onMouseOver="showtip(this,event,'MED14-independent group 3 enhancer GRCh37_chr20:50051304-50052503')" onMouseOut="hidetip()" coords="168,191,238,199" alt="Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:50051304-50052503" href="/gene/126863050" />
<area shape="rect" onMouseOver="showtip(this,event,'P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:50063011-50064210')" onMouseOut="hidetip()" coords="174,35,244,43" alt="Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:50063011-50064210" href="/gene/121627911" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50067417-50067918')" onMouseOut="hidetip()" coords="177,119,247,127" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50067417-50067918" href="/gene/127893722" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50072771-50073376')" onMouseOut="hidetip()" coords="179,203,249,211" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50072771-50073376" href="/gene/127893723" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50079139-50080099')" onMouseOut="hidetip()" coords="183,131,253,139" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50079139-50080099" href="/gene/127893724" />
<area shape="rect" onMouseOver="showtip(this,event,'MED14-independent group 3 enhancer GRCh37_chr20:50103914-50105113')" onMouseOut="hidetip()" coords="196,143,266,151" alt="Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:50103914-50105113" href="/gene/126863051" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50105077-50105578')" onMouseOut="hidetip()" coords="196,155,266,163" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50105077-50105578" href="/gene/127882580" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18112')" onMouseOut="hidetip()" coords="201,215,271,223" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18112" href="/gene/130066173" />
<area shape="rect" onMouseOver="showtip(this,event,'microRNA 3194')" onMouseOut="hidetip()" coords="203,47,248,55" alt="Neighboring gene microRNA 3194" href="/gene/100422889" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18113')" onMouseOut="hidetip()" coords="219,59,289,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18113" href="/gene/130066174" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18114')" onMouseOut="hidetip()" coords="219,227,289,235" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18114" href="/gene/130066175" />
<area shape="rect" onMouseOver="showtip(this,event,'P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:50149441-50150640')" onMouseOut="hidetip()" coords="220,239,290,247" alt="Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:50149441-50150640" href="/gene/126863052" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50157559-50158228')" onMouseOut="hidetip()" coords="224,71,294,79" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50157559-50158228" href="/gene/127893725" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 13041')" onMouseOut="hidetip()" coords="225,83,295,91" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13041" href="/gene/130066176" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 13042')" onMouseOut="hidetip()" coords="225,251,295,259" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13042" href="/gene/130066177" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50186888-50187388')" onMouseOut="hidetip()" coords="239,95,309,103" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50186888-50187388" href="/gene/127893726" />
<area shape="rect" onMouseOver="showtip(this,event,'CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:50224727-50225926')" onMouseOut="hidetip()" coords="259,35,329,43" alt="Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:50224727-50225926" href="/gene/126863053" />
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr20:50226387-50226540')" onMouseOut="hidetip()" coords="260,47,330,55" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr20:50226387-50226540" href="/gene/129664650" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50240809-50241341')" onMouseOut="hidetip()" coords="267,107,337,115" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50240809-50241341" href="/gene/127893727" />
<area shape="rect" onMouseOver="showtip(this,event,'BRD4-independent group 4 enhancer GRCh37_chr20:50247413-50248612')" onMouseOut="hidetip()" coords="271,119,341,127" alt="Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:50247413-50248612" href="/gene/126863054" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 9373')" onMouseOut="hidetip()" coords="275,131,345,139" alt="Neighboring gene Sharpr-MPRA regulatory region 9373" href="/gene/121853013" />
<area shape="rect" onMouseOver="showtip(this,event,'ATPase phospholipid transporting 9A (putative)')" onMouseOut="hidetip()" coords="288,143,405,151" alt="Neighboring gene ATPase phospholipid transporting 9A (putative)" href="/gene/10079" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 11561')" onMouseOut="hidetip()" coords="305,23,375,31" alt="Neighboring gene Sharpr-MPRA regulatory region 11561" href="/gene/125387299" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr20:50315099-50315599')" onMouseOut="hidetip()" coords="306,59,376,67" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:50315099-50315599" href="/gene/127893728" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 2244')" onMouseOut="hidetip()" coords="308,71,378,79" alt="Neighboring gene Sharpr-MPRA regulatory region 2244" href="/gene/125387300" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50318515-50319015')" onMouseOut="hidetip()" coords="308,83,378,91" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50318515-50319015" href="/gene/127893729" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG hESC enhancer GRCh37_chr20:50321824-50322382')" onMouseOut="hidetip()" coords="310,95,380,103" alt="Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:50321824-50322382" href="/gene/127893730" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50323455-50323954')" onMouseOut="hidetip()" coords="311,155,381,163" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50323455-50323954" href="/gene/127893731" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG hESC enhancer GRCh37_chr20:50327032-50327577')" onMouseOut="hidetip()" coords="313,167,383,175" alt="Neighboring gene NANOG hESC enhancer GRCh37_chr20:50327032-50327577" href="/gene/127893732" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50329473-50329983')" onMouseOut="hidetip()" coords="314,179,384,187" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50329473-50329983" href="/gene/127893733" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 2265')" onMouseOut="hidetip()" coords="328,191,398,199" alt="Neighboring gene Sharpr-MPRA regulatory region 2265" href="/gene/125387301" />
<area shape="rect" onMouseOver="showtip(this,event,'Sharpr-MPRA regulatory region 2507')" onMouseOut="hidetip()" coords="330,35,400,43" alt="Neighboring gene Sharpr-MPRA regulatory region 2507" href="/gene/125387302" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50366388-50366998')" onMouseOut="hidetip()" coords="333,47,403,55" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50366388-50366998" href="/gene/127893734" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50378781-50379465')" onMouseOut="hidetip()" coords="340,107,410,115" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50378781-50379465" href="/gene/127893735" />
<area shape="rect" onMouseOver="showtip(this,event,'ribosomal protein L29 pseudogene 35')" onMouseOut="hidetip()" coords="345,119,395,127" alt="Neighboring gene ribosomal protein L29 pseudogene 35" href="/gene/100419570" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr20:50405009-50405510')" onMouseOut="hidetip()" coords="353,131,423,139" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:50405009-50405510" href="/gene/127893736" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr20:50405511-50406010')" onMouseOut="hidetip()" coords="353,203,423,211" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:50405511-50406010" href="/gene/127893737" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50406470-50407036')" onMouseOut="hidetip()" coords="353,215,423,223" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50406470-50407036" href="/gene/127893738" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50407037-50407602')" onMouseOut="hidetip()" coords="353,227,423,235" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50407037-50407602" href="/gene/127893739" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr20:50411851-50412350')" onMouseOut="hidetip()" coords="353,239,423,247" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50411851-50412350" href="/gene/127893740" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50415843-50416766')" onMouseOut="hidetip()" coords="353,251,423,259" alt="Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50415843-50416766" href="/gene/127893741" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18116')" onMouseOut="hidetip()" coords="353,263,423,271" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18116" href="/gene/130066178" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50417479-50418121')" onMouseOut="hidetip()" coords="353,275,423,283" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50417479-50418121" href="/gene/127893742" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac hESC enhancer GRCh37_chr20:50418765-50419406')" onMouseOut="hidetip()" coords="353,287,423,295" alt="Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:50418765-50419406" href="/gene/127893743" />
<area shape="rect" onMouseOver="showtip(this,event,'spalt like transcription factor 4')" onMouseOut="hidetip()" coords="385,23,423,31" alt="Neighboring gene spalt like transcription factor 4" href="/gene/57167" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="4773">
<option value="NC_000020.11_51386962_51562838">NC_000020.11 Chromosome 20 Reference GRCh38.p14 Primary Assembly</option>
<option value="NC_060944.1_53157542_53333580">NC_060944.1 Chromosome 20 Alternate T2T-CHM13v2.0</option>
<option value="NC_000020.10_50003499_50179377">NC_000020.10 Chromosome 20 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000020" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000020.11?report=graph&amp;from=51360581&amp;to=51589219&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_000020.11">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000020.11?report=fasta&amp;from=51386963&amp;to=51562839&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_000020.11">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000020.11?report=genbank&amp;from=51386963&amp;to=51562839&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_000020.11">GenBank</a>
</p>
<div id="divNC_000020" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000020.11&amp;from=51360581&amp;to=51589219&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000020.11&amp;from=51360581&amp;to=51589219&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000020.11" sid="1" type="hidden" id="nucleotideLink_NC_000020_11_51386962_51562838" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000020.11?report=graph&amp;amp;from=51360581&amp;amp;to=51589219&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4773&amp;amp;link_uid=NC_000020.11&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000020.11?report=fasta&amp;amp;from=51386963&amp;amp;to=51562839&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4773&amp;amp;link_uid=NC_000020.11&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000020.11?report=genbank&amp;amp;from=51386963&amp;amp;to=51562839&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4773&amp;amp;link_uid=NC_000020.11&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000020.11" sid="1" type="hidden" id="relString_NC_000020_11_51386962_51562838" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000020.11&amp;amp;from=51360581&amp;amp;to=51589219&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
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</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/4773/?report=expression" data-url="/gene/4773/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/4773" data-report-type="summary">
<div>
<script type="text/javascript">
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[{"id": "metadata_9606_SAMN03267777", "gene": 4773, "sample_id": "SAMN03267777", "full_rpkm": 0.0314777, "exp_rpkm": 0.0315, "exp_total": 3355, "project_desc": "PRJNA270632", "_version_": 1785734387344605195, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 20wk", "exp_Mcount": 10280.0}], "lung 10wk": [{"id": "metadata_9606_SAMN03267770", "gene": 4773, "sample_id": "SAMN03267770", "full_rpkm": 0.546647, "exp_rpkm": 0.547, "exp_total": 33738, "project_desc": "PRJNA270632", "_version_": 1785734387344605193, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5952.75}, {"id": "metadata_9606_SAMN03267767", "gene": 4773, "sample_id": "SAMN03267767", "full_rpkm": 0.450959, "exp_rpkm": 0.451, "exp_total": 24459, "project_desc": "PRJNA270632", "_version_": 1785734387344605194, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5231.26}], "lung 17wk": [{"id": "metadata_9606_SAMN03267778", "gene": 4773, "sample_id": "SAMN03267778", "full_rpkm": 0.51681, "exp_rpkm": 0.517, "exp_total": 33512, "project_desc": "PRJNA270632", "_version_": 1785734387344605191, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 6254.23}, {"id": "metadata_9606_SAMN03267776", "gene": 4773, "sample_id": "SAMN03267776", "full_rpkm": 0.498186, "exp_rpkm": 0.498, "exp_total": 19335, "project_desc": "PRJNA270632", "_version_": 1785734387344605192, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 3743.33}], "lung 20wk": [{"id": "metadata_9606_SAMN03267780", "gene": 4773, "sample_id": "SAMN03267780", "full_rpkm": 0.295892, "exp_rpkm": 0.296, "exp_total": 28439, "project_desc": "PRJNA270632", "_version_": 1785734387344605189, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 9270.13}, {"id": "metadata_9606_SAMN03267768", "gene": 4773, "sample_id": "SAMN03267768", "full_rpkm": 0.623854, "exp_rpkm": 0.624, "exp_total": 41089, "project_desc": "PRJNA270632", "_version_": 1785734387344605190, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 6352.54}], "stomach 10wk": [{"id": "metadata_9606_SAMN03267773", "gene": 4773, "sample_id": "SAMN03267773", "full_rpkm": 0.548721, "exp_rpkm": 0.549, "exp_total": 37446, "project_desc": "PRJNA270632", "_version_": 1785734387344605187, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 6582.02}, {"id": "metadata_9606_SAMN03267779", "gene": 4773, "sample_id": "SAMN03267779", "full_rpkm": 0.767923, "exp_rpkm": 0.768, "exp_total": 57596, "project_desc": "PRJNA270632", "_version_": 1785734387344605188, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 7234.02}], "stomach 16wk": [{"id": "metadata_9606_SAMN03267774", "gene": 4773, "sample_id": "SAMN03267774", "full_rpkm": 0.623218, "exp_rpkm": 0.623, "exp_total": 40187, "project_desc": "PRJNA270632", "_version_": 1785734387344605186, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 16wk", "exp_Mcount": 6219.43}], "stomach 18wk": [{"id": "metadata_9606_SAMN03267771", "gene": 4773, "sample_id": "SAMN03267771", "full_rpkm": 0.934808, "exp_rpkm": 0.935, "exp_total": 56412, "project_desc": "PRJNA270632", "_version_": 1785734387344605185, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 18wk", "exp_Mcount": 5820.42}], "stomach 20wk": [{"id": "metadata_9606_SAMN03267765", "gene": 4773, "sample_id": "SAMN03267765", "full_rpkm": 0.93097, "exp_rpkm": 0.931, "exp_total": 43383, "project_desc": "PRJNA270632", "_version_": 1785734387342508032, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4494.58}, {"id": "metadata_9606_SAMN03267781", "gene": 4773, "sample_id": "SAMN03267781", "full_rpkm": 1.13046, "exp_rpkm": 1.13, "exp_total": 53519, "project_desc": "PRJNA270632", "_version_": 1785734387343556608, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4566.24}, {"id": "metadata_9606_SAMN03267783", "gene": 4773, "sample_id": "SAMN03267783", "full_rpkm": 0.80313, "exp_rpkm": 0.803, "exp_total": 40007, "project_desc": "PRJNA270632", "_version_": 1785734387344605184, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4804.58}]}
window.taxId = 9606
</script>
<div>
<select name="p" id="project-selector">
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
<div id="gene-expr-details" class="expression-chart"></div>
</div>
</div>
</div>
<script type="text/javascript" src="https://www.gstatic.com/charts/loader.js"></script>
<script type="text/javascript">
google.charts.load('current', {
'packages':[ 'corechart']
});
</script>
</div>
</div>
</div>
<div class="rprt-section gene-bibliography">
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<div class="generif-pubmed">
<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
<div class="generefbl-link">
<ol class="generef-link">
<li>
<a href="/pubmed/29432148/" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=29432148">(15)N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins.</a>
<span class="pubmed-auth-date"> Chhabra S, <em>et al</em>. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432148, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5828609/" ref="ordinalpos=0&amp;ncbi_uid=4773&amp;link_uid=PMC5828609">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/22718120/" ref="ordinalpos=2&amp;ncbi_uid=4773&amp;link_uid=22718120">NFATc2 is a potential therapeutic target in human melanoma.</a>
<span class="pubmed-auth-date"> Perotti V, <em>et al</em>. J Invest Dermatol, 2012 Nov. PMID 22718120</span>
</li>
<li>
<a href="/pubmed/15471864/" ref="ordinalpos=3&amp;ncbi_uid=4773&amp;link_uid=15471864">The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway.</a>
<span class="pubmed-auth-date"> Granja AG, <em>et al</em>. J Biol Chem, 2004 Dec 17. PMID 15471864</span>
</li>
<li>
<a href="/pubmed/26387540/" ref="ordinalpos=4&amp;ncbi_uid=4773&amp;link_uid=26387540">NFATc2 is an intrinsic regulator of melanoma dedifferentiation.</a>
<span class="pubmed-auth-date"> Perotti V, <em>et al</em>. Oncogene, 2016 Jun 2. PMID 26387540</span>
</li>
<li>
<a href="/pubmed/11231878/" ref="ordinalpos=5&amp;ncbi_uid=4773&amp;link_uid=11231878">Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp.</a>
<span class="pubmed-auth-date"> Kim LJ, <em>et al</em>. BMC Immunol, 2000. PMID 11231878, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC31347/" ref="ordinalpos=0&amp;ncbi_uid=4773&amp;link_uid=PMC31347">Free PMC Article</a></span></span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=4773" title="See all 259 citations in Pubmed">See all (259) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/37399784" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=37399784">STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38528665" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=38528665">The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma.</a>
<div id="gene-popper2" class="gene-rif-popper">Title: The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38448411" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=38448411">The RNA m[6]A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: The RNA m(6)A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38254207" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=38254207">Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.</a>
<div id="gene-popper4" class="gene-rif-popper">Title: Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37933452" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=37933452">Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38035702" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=38035702">Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on the Proliferation and Migration Behavior of Pancreatic Cancer Cells.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on the Proliferation and Migration Behavior of Pancreatic Cancer Cells.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37909980" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=37909980">Over-expression of cFos by the Transcription Factors NFATc2 and Sp1 in Pancreatic Cancer Cells.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: Over-expression of cFos by the Transcription Factors NFATc2 and Sp1 in Pancreatic Cancer Cells.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37904191" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=37904191">NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37285922" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=37285922">Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/36779231" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=36779231">Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=4773&amp;sym=NFATC2&amp;name=nuclear factor of activated T cells 2&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=4773&amp;symbol=NFATC2;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=4773" class="seeall-generif">See all GeneRIFs (158)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=NFATC2[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=4773">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="associatedconditions">Associated conditions</h3>
<table class="jig-ncbigrid gtr-associated-cond">
<thead>
<tr>
<th class="description">Description</th>
<th>Tests</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<a href="/gtr/conditions/C5774305" ref="ncbi_uid=4773&amp;link_uid=C5774305">Joint contractures, osteochondromas, and B-cell lymphoma</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C5774305" ref="ncbi_uid=4773&amp;link_uid=C5774305">C5774305</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/620232" ref="ncbi_uid=4773"> 620232</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<span class="gtr-na">not available</span>
</td>
</tr>
</tbody>
</table>
</div>
<div>
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
<thead>
<tr>
<th class="description">Description</th>
</tr>
</thead>
<tbody>
<tr>
<td>A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23817569">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23817569">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/25158072">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/25158072">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23918034">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23918034">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/24529757">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/24529757">PubMed</a></span></div></div></div></td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=NFATC2[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=4773" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=4773[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=4773[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation</td>
<td headers="hivpub">
<a title="PubMed Id(s): 16260021,7957556" href="/pubmed/16260021,7957556">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Using either anti-CD4 monoclonal antibodies or HIV-1 gp120 binding to CD4 reveals a common epitope-specific activation of both the HIV-1 LTR and of the transcription factors NF-kappa B and NF-AT</td>
<td headers="hivpub">
<a title="PubMed Id(s): 16260021,8814265" href="/pubmed/16260021,8814265">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872818">Nef</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">HIV-1 Vpu downregulates NRON levels but HIV-1 Nef upregulates NRON levels in Jurkat cells, leading to reciprocal regulation in NFAT activity through NRON by Vpu and Nef</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25728138" href="/pubmed/25728138">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">The induction of NFAT1 and NFAT2 is impaired by HIV-1 Nef in sub-optimally activated/resting T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24187576,21176845" href="/pubmed/24187576,21176845">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">HIV-1 Nef super induces the transcription factors NFAT1 and NFAT2 during activation of HIV-infected quiescent T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24187576,23227982,21176845" href="/pubmed/24187576,23227982,21176845">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629358">Tat</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22593154" href="/pubmed/22593154">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2</td>
<td headers="hivpub">
<a title="PubMed Id(s): 18097055" href="/pubmed/18097055">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22077140,16690925" href="/pubmed/22077140,16690925">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">NFAT1 inhibits Tat-mediated transactivation of the HIV-1 LTR promoter through a direct binding interaction between the two proteins</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22422068,22077140,10207088,8834464" href="/pubmed/22422068,22077140,10207088,8834464">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat enhances NFAT1-driven transcription in Jurkat T cells through a direct protein-protein interaction between the two proteins</td>
<td headers="hivpub">
<a title="PubMed Id(s): 20139419,10207088" href="/pubmed/20139419,10207088">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT</td>
<td headers="hivpub">
<a title="PubMed Id(s): 12482669" href="/pubmed/12482669">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat upregulation of the IL-2 promoter maps to the NFAT motif of the IL-2 enhancer, suggesting Tat-mediated enhancement of NFAT1 transactivation may explain the upregulation of IL-2 that occurs during HIV-1 infection</td>
<td headers="hivpub">
<a title="PubMed Id(s): 10207088,7999066" href="/pubmed/10207088,7999066">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat binds to NFAT1, an interaction mediated by the N-terminus of Tat (amino acids 1-26) and the transactivation domain of NFAT1 (amino acids 1-96)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 10207088" href="/pubmed/10207088">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872817">Vpr</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">HIV-1 Vpr upregulates NFAT-directed gene expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 12788643" href="/pubmed/12788643">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629366">Vpu</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155945">vpu</a>
</td>
<td headers="hivinter">HIV-1 Vpu downregulates NRON levels but HIV-1 Nef upregulates NRON levels in Jurkat cells, leading to reciprocal regulation in NFAT activity through NRON by Vpu and Nef</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25728138" href="/pubmed/25728138">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/25121907">reverse transcriptase</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155348">gag-pol</a>
</td>
<td headers="hivinter">NFATc facilitates HIV-1 RT reverse transcription activity and enhances HIV-1 infectivity in human T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 9845362" href="/pubmed/9845362">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/4773#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/4773/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">D20S857 (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=54045%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=54045">UniSTS:54045</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH36387 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=2606%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=2606">UniSTS:2606</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">AL032542 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=93288%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=93288">UniSTS:93288</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-144024 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=172138%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=172138">UniSTS:172138</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">SHGC-85834 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=103835%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=103835">UniSTS:103835</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">STS-M78243 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=36816%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=36816">UniSTS:36816</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">RH38986 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=91092%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=91092">UniSTS:91092</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D20S128E (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=78049%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=78049">UniSTS:78049</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">GDB:555597 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=157689%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=157689">UniSTS:157689</a></li></ul></li>
</ul>
</div>
</div>
<div></div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/4773/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0071889">enables 14-3-3 protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> EXP</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Experiment<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/29432148" target="_blank" title="PubMed ID 29432148" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=29432148">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0003677">enables DNA binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-2-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8668213" target="_blank" title="PubMed ID 8668213" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=8668213">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001228">enables DNA-binding transcription activator activity, RNA polymerase II-specific</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-3-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0003700">enables DNA-binding transcription factor activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-4-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8668213" target="_blank" title="PubMed ID 8668213" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=8668213">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000981">enables DNA-binding transcription factor activity, RNA polymerase II-specific</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-5-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000981">enables DNA-binding transcription factor activity, RNA polymerase II-specific</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISA</a>
<div id="evidence-code-6-0" class="ecode">Inferred from Sequence Alignment<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001227">enables DNA-binding transcription repressor activity, RNA polymerase II-specific</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-7-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000978">enables RNA polymerase II cis-regulatory region sequence-specific DNA binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-8-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0003682">enables chromatin binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-9-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060090">enables molecular adaptor activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> EXP</a>
<div id="evidence-code-10-0" class="ecode">Inferred from Experiment<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/29432148" target="_blank" title="PubMed ID 29432148" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=29432148">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019902">enables phosphatase binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-11-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/26248042" target="_blank" title="PubMed ID 26248042" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=26248042">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-12-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/16873067,17377532,18218901,19505873,20557936,21458306,21983832,23105117,24561192,24954618,25609649" target="_blank" title="PubMed ID 16873067,17377532,18218901,19505873,20557936,21458306,21983832,23105117,24561192,24954618,25609649" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=16873067,17377532,18218901,19505873,20557936,21458306,21983832,23105117,24561192,24954618,25609649">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:1990837">enables sequence-specific double-stranded DNA binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-13-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/28473536" target="_blank" title="PubMed ID 28473536" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=28473536">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050853">involved_in B cell receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17875758" target="_blank" title="PubMed ID 17875758" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=17875758">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006974">involved_in DNA damage response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17875758" target="_blank" title="PubMed ID 17875758" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=17875758">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0033173">involved_in calcineurin-NFAT signaling cascade</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051216">involved_in cartilage development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/35789258" target="_blank" title="PubMed ID 35789258" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=35789258">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016477">involved_in cell migration</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-5-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/21871017" target="_blank" title="PubMed ID 21871017" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=21871017">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0071277">involved_in cellular response to calcium ion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-6-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0140742">involved_in lncRNA transcription</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0014904">involved_in myotube cell development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000122">involved_in negative regulation of transcription by RNA polymerase II</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-9-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1905064">involved_in negative regulation of vascular associated smooth muscle cell differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23853098" target="_blank" title="PubMed ID 23853098" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=23853098">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030890">involved_in positive regulation of B cell proliferation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-11-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17875758" target="_blank" title="PubMed ID 17875758" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=17875758">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045893">acts_upstream_of_or_within positive regulation of DNA-templated transcription</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-12-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15790681" target="_blank" title="PubMed ID 15790681" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=15790681">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">involved_in positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-13-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1901741">involved_in positive regulation of myoblast fusion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-14-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045944">involved_in positive regulation of transcription by RNA polymerase II</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-15-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006355">involved_in regulation of DNA-templated transcription</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-16-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8668213" target="_blank" title="PubMed ID 8668213" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=8668213">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006357">involved_in regulation of transcription by RNA polymerase II</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
<div id="evidence-code-17-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9510247" target="_blank" title="PubMed ID 9510247" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=9510247">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0009410">involved_in response to xenobiotic stimulus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-18-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17875758" target="_blank" title="PubMed ID 17875758" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=17875758">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006366">involved_in transcription by RNA polymerase II</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-19-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000785">located_in chromatin</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISA</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Sequence Alignment<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">located_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-2-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12656674" target="_blank" title="PubMed ID 12656674" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=12656674">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">located_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-3-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/8668213" target="_blank" title="PubMed ID 8668213" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=8668213">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-5-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005654">located_in nucleoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005654">located_in nucleoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-7-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">is_active_in nucleus</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-8-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">located_in nucleus</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-9-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12370307,12656674" target="_blank" title="PubMed ID 12370307,12656674" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=12370307,12656674">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">located_in nucleus</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-10-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/8668213" target="_blank" title="PubMed ID 8668213" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=8668213">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:1990904">part_of ribonucleoprotein complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-11-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035976">part_of transcription factor AP-1 complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-12-2" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9510247" target="_blank" title="PubMed ID 9510247" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=9510247">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005667">part_of transcription regulator complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-13-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>nuclear factor of activated T-cells, cytoplasmic 2</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>NF-ATc2</dd>
<dd>NFAT pre-existing subunit</dd>
<dd>NFAT transcription complex, preexisting component</dd>
<dd>T cell transcription factor NFAT1</dd>
<dd>nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2</dd>
<dd>nuclear factor of activated T-cells, preexisting component</dd>
<dd>preexisting nuclear factor of activated T-cells 2</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=4773&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="mrnaandproteins-p142928800">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_001136021.3">NM_001136021.3</a><a href="/protein/NP_001129493.1">NP_001129493.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform D</p>
<p>
<a href="/ipg/NP_001129493.1/" ref="ncbi_uid=4773">See identical proteins and their annotated locations for NP_001129493.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (3) uses an alternate first exon and contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (D) has shorter and distinct N- and C-termini compared to isoform C.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AK226146, AL035682, AL035684, BE674599, EU887574">AK226146, AL035682, AL035684, BE674599, EU887574</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS46614.1">CCDS46614.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/Q13469" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q13469</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000396471.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENSP00000396471.1</a>, <a href="http://www.ensembl.org/id/ENST00000414705.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENST00000414705.5</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001129493.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">378</span><span class="cddto">552</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">557</span><span class="cddto">657</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001258292.2">NM_001258292.2</a><a href="/protein/NP_001245221.1">NP_001245221.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform E</p>
<p>
<a href="/ipg/NP_001245221.1/" ref="ncbi_uid=4773">See identical proteins and their annotated locations for NP_001245221.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (4) uses an alternate first exon compared to variant 2. The resulting isoform (E) has a shorter and distinct N-terminus compared to isoform C.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AK226146, AL035682, AL035684, BE674599">AK226146, AL035682, AL035684, BE674599</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS68157.1">CCDS68157.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/Q13469" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q13469</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000477370.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENSP00000477370.1</a>, <a href="http://www.ensembl.org/id/ENST00000609943.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENST00000609943.5</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001245221.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">378</span><span class="cddto">552</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">557</span><span class="cddto">657</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001258294.2">NM_001258294.2</a><a href="/protein/NP_001245223.1">NP_001245223.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform F</p>
<p>
<a href="/ipg/NP_001245223.1/" ref="ncbi_uid=4773">See identical proteins and their annotated locations for NP_001245223.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (5) has an alternate first exon, an alternate exon in the 3' end, and uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (F) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform C. Variants 5 and 7 both encode the same isoform (F).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AL035682, AL035684, BE674599, EU887575">AL035682, AL035684, BE674599, EU887575</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS68156.1">CCDS68156.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/Q13469" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q13469</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000477342.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENSP00000477342.1</a>, <a href="http://www.ensembl.org/id/ENST00000609507.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENST00000609507.1</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001245223.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">179</span><span class="cddto">353</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">358</span><span class="cddto">458</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001258295.2">NM_001258295.2</a><a href="/protein/NP_001245224.1">NP_001245224.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform G</p>
<p>
<a href="/ipg/NP_001245224.1/" ref="ncbi_uid=4773">See identical proteins and their annotated locations for NP_001245224.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (6) has an alternate first exon and uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (G) is shorter at the N-terminus compared to isoform C. Variants 6 and 8 both encode the same isoform (G).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AL035682, AL035684, BE674599, EU887579">AL035682, AL035684, BE674599, EU887579</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B5B2P4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">B5B2P4</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001245224.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">179</span><span class="cddto">353</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">358</span><span class="cddto">458</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001258296.2">NM_001258296.2</a><a href="/protein/NP_001245225.1">NP_001245225.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform F</p>
<p>
<a href="/ipg/NP_001245225.1/" ref="ncbi_uid=4773">See identical proteins and their annotated locations for NP_001245225.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (7) uses an alternate splice junction at the 5' end of a coding exon and contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (F) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform C. Variants 5 and 7 both encode the same isoform (F).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AL035682, BE674599, EU887576">AL035682, BE674599, EU887576</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS68156.1">CCDS68156.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/Q13469" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q13469</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000477142.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENSP00000477142.1</a>, <a href="http://www.ensembl.org/id/ENST00000610033.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENST00000610033.5</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001245225.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">179</span><span class="cddto">353</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">358</span><span class="cddto">458</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_001258297.2">NM_001258297.2</a><a href="/protein/NP_001245226.1">NP_001245226.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform G</p>
<p>
<a href="/ipg/NP_001245226.1/" ref="ncbi_uid=4773">See identical proteins and their annotated locations for NP_001245226.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (8) uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (G) is shorter at the N-terminus compared to isoform C. Variants 6 and 8 both encode the same isoform (G).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AL035682, BE674599, EU887580">AL035682, BE674599, EU887580</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/B5B2P4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">B5B2P4</a>
</dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001245226.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">179</span><span class="cddto">353</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">358</span><span class="cddto">458</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_012340.5">NM_012340.5</a><a href="/protein/NP_036472.2">NP_036472.2</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform B</p>
<p>
<a href="/ipg/NP_036472.2/" ref="ncbi_uid=4773">See identical proteins and their annotated locations for NP_036472.2</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (1) contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (B) has a shorter and distinct C-terminus compared to isoform C.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AL035682, BE674599, EU887573, EU887576">AL035682, BE674599, EU887573, EU887576</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS33488.1">CCDS33488.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd>
<a href="https://www.uniprot.org/uniprot/Q13469" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q13469</a>
</dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000360619.3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENSP00000360619.3</a>, <a href="http://www.ensembl.org/id/ENST00000371564.8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENST00000371564.8</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_036472.2">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">398</span><span class="cddto">572</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">577</span><span class="cddto">677</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_173091.4">NM_173091.4</a><a href="/protein/NP_775114.1">NP_775114.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform C</p>
<p>
<a href="/ipg/NP_775114.1/" ref="ncbi_uid=4773">See identical proteins and their annotated locations for NP_775114.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (2) encodes the longest isoform (C).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AL035682, BE674599, EU887576, EU887578">AL035682, BE674599, EU887576, EU887578</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS13437.1">CCDS13437.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B5B2N8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">B5B2N8</a>, <a href="https://www.uniprot.org/uniprot/B5B2N9" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">B5B2N9</a>, <a href="https://www.uniprot.org/uniprot/B5B2P0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">B5B2P0</a>, <a href="https://www.uniprot.org/uniprot/B5B2P2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">B5B2P2</a>, <a href="https://www.uniprot.org/uniprot/B5B2P3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">B5B2P3</a>, <a href="https://www.uniprot.org/uniprot/Q13468" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q13468</a>, <a href="https://www.uniprot.org/uniprot/Q13469" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q13469</a>, <a href="https://www.uniprot.org/uniprot/Q5TFW7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q5TFW7</a>, <a href="https://www.uniprot.org/uniprot/Q5TFW8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q5TFW8</a>, <a href="https://www.uniprot.org/uniprot/Q9NPX6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q9NPX6</a>, <a href="https://www.uniprot.org/uniprot/Q9NQH3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q9NQH3</a>, <a href="https://www.uniprot.org/uniprot/Q9UJR2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">Q9UJR2</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000379330.3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENSP00000379330.3</a>, <a href="http://www.ensembl.org/id/ENST00000396009.7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4773&amp;nlmid=&amp;db=gene">ENST00000396009.7</a></dd>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_775114.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">398</span><span class="cddto">572</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">577</span><span class="cddto">677</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p117079488">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p117079488">Genomic </h4>
<ol>
<li>
<p>NC_000020.11 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>51386963..51562839 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000020.11?from=51386963&amp;to=51562839&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_000020.11?from=51386963&amp;to=51562839&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_000020.11?from=51386963&amp;to=51562839&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_000020.11?from=51386963&amp;to=51562839&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_000020.11?from=51360581&amp;to=51589219&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_000020.11?from=51360581&amp;to=51589219&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p108016608">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_017027851.2">XM_017027851.2</a><a href="/protein/XP_016883340.1">XP_016883340.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform X3</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_011528826.3">XM_011528826.3</a><a href="/protein/XP_011527128.1">XP_011527128.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform X4</p>
<dl>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011527128.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">179</span><span class="cddto">353</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">358</span><span class="cddto">458</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011528825.3">XM_011528825.3</a><a href="/protein/XP_011527127.1">XP_011527127.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform X2</p>
<dl>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011527127.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">378</span><span class="cddto">552</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">557</span><span class="cddto">657</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011528824.3">XM_011528824.3</a><a href="/protein/XP_011527126.1">XP_011527126.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1</p>
<dl>
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011527126.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=143641">cd07881</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">398</span><span class="cddto">572</span></dt>
<dd class="clearfix"> RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238583">cd01178</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">577</span><span class="cddto">677</span></dt>
<dd class="clearfix"> IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.</dd>
</dl>
</dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p139708784">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p139708784">Genomic </h4>
<ol>
<li>
<p>NC_060944.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>53157543..53333581 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060944.1?from=53157543&amp;to=53333581&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_060944.1?from=53157543&amp;to=53333581&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_060944.1?from=53157543&amp;to=53333581&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_060944.1?from=53157543&amp;to=53333581&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_060944.1?from=53131136&amp;to=53359986&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=NC_060944.1?from=53131136&amp;to=53359986&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p101456688">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_054323454.1">XM_054323454.1</a><a href="/protein/XP_054179429.1">XP_054179429.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform X3</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_054323455.1">XM_054323455.1</a><a href="/protein/XP_054179430.1">XP_054179430.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform X4</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_054323453.1">XM_054323453.1</a><a href="/protein/XP_054179428.1">XP_054179428.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform X2</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_054323452.1">XM_054323452.1</a><a href="/protein/XP_054179427.1">XP_054179427.1</a>  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1</p>
<dl></dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/4773/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">Q13469.2</td>
<td headers="rs-link rs-genepept">
<a href="/protein/68846905" ref="ordinalpos=1&amp;ncbi_uid=4773&amp;link_uid=68846905">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/Q13469">UniProtKB/Swiss-Prot:Q13469</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/NFATC2?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>NFATC2 products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000101096" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>NFATC2 gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/4773/" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (23 hits/1389 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>NFATC2</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=NFATC2_1" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>NFATC2_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/Q13469" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Reproductive&amp;modeInput=Absolute&amp;primaryGene=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D4773%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=81223" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000101096" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN57519/" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN57517/" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN57518/" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Pharmacogenomics Knowledge Base</li>
<ul>
<li>
<a target="_blank" href="https://www.pharmgkb.org/gene/PA31583" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4067">
<span>Annotated Pharmacogenomic Information for NFATC2 [PharmGKB]</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/NFATC2" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=NFATC2" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for NFATC2</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/nfatc2/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>NFATC2/NFAT1 Proteins</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/nfatc2/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>NFATC2/NFAT1 Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/nfatc2/lysates?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=lysates" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>NFATC2/NFAT1 Lysates</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Creative Biogene</li>
<ul>
<li>
<a target="_blank" href="https://www.creative-biogene.com/genesearch/NFATc2.html" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10094">
<span>nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/NFATC2-antibody.html" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/NFATC2-antibody.html" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=11&amp;field=5&amp;key=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order shRNA clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&amp;field=5&amp;prt=16&amp;key=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order miRNA target clones</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=NFATC2;" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=Nfatc2" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order Nfatc2 cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=4773" ref="itool=Gene_FullReport&amp;uid=4773&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
<div id="urls-in-genombrowser" style="display:none">
</div>
</div>
</div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
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</li>
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<div class="portlet_title">
<h3>Related information</h3>
</div>
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<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&amp;from_uid=4773" ref="log$=recordlinks">3D structures</a>
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=4773" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=4773" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=4773" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&amp;from_uid=4773" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=4773" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=4773" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=4773" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=4773" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=4773" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=4773" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=4773" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=4773" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=4773" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=4773" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gap?LinkName=gene_gap&amp;from_uid=4773" ref="log$=recordlinks">GAP</a>
<div class="brieflinkpop offscreen_noflow">GAP Links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=4773" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=4773" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=4773" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=4773[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=4773" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&amp;from_uid=4773" ref="log$=recordlinks">MedGen</a>
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=4773" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=4773" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=4773" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=4773" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=4773" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=4773" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=4773" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=4773" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=4773" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=4773" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=4773" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=4773" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&amp;from_uid=4773" ref="log$=recordlinks">Related gene-specific medical variations</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=4773" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=4773" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=4773[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7776">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000101096">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:7776">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=4773">AceView</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_012340">UCSC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=NFATC2&amp;geneID=4773&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:4773">KEGG</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-feedback">
<div class="portlet_head">
<div class="portlet_title">
<h3>Feedback</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
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<ul>
<li>
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=4773&amp;symbol=NFATC2">Submit Correction</a>
</li>
<li>
<a href="/gene/submit-generif?geneId=4773&amp;sym=NFATC2&amp;name=nuclear factor of activated T cells 2&amp;org=Homo sapiens">Submit GeneRIF</a>
</li>
</ul>
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<div class="portlet brieflink dis-subscription">
<div class="portlet_head">
<div class="portlet_title">
<h3>Subscription</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
</li>
</ul>
</div>
</div>
</div>
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<h3>Recent activity</h3>
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<ul id="activity">
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9e28ff4a390645e47e6e3">NFATC2 nuclear factor of activated T cells 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">NFATC2 nuclear factor of activated T cells 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4773</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9e28da68b6b5afc7e47f2">nuclear factor of activated T-cells, cytoplasmic 2 isoform B [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">nuclear factor of activated T-cells, cytoplasmic 2 isoform B [Homo sapiens]<div class="brieflinkpopdesc">gi|27886539|ref|NP_036472.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9e289b15b832ebc199406">NFATC1 nuclear factor of activated T cells 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">NFATC1 nuclear factor of activated T cells 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4772</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9e287b15b832ebc198bc5">nuclear factor of activated T-cells, cytoplasmic 1 isoform B [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">nuclear factor of activated T-cells, cytoplasmic 1 isoform B [Homo sapiens]<div class="brieflinkpopdesc">gi|19923350|ref|NP_006153.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9e286f4a390645e47aa8f">NEU3 neuraminidase 3 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">NEU3 neuraminidase 3 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:10825</div></div>
<div class="tertiary">Gene</div>
</li>
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