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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'3792',linkname:'',idsfromresult:'4600',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9e247d74f6769104143db" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="3792" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">MX2</span> MX dynamin like GTPase 2 [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 4600, updated on
4-Mar-2025</span>
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<div class="rprt-section gene-summary">
<section class="rprt-section-header" id="summary">
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<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">MX2<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>MX dynamin like GTPase 2<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7533" data-gblink-text="Ensembl">HGNC:HGNC:7533</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000183486" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000183486">Ensembl:ENSG00000183486</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/147890" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=147890">MIM:147890;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:7533" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=HGNC:7533">AllianceGenome:HGNC:7533</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>MXB</dd>
<dt>Summary</dt>
<dd>The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]</dd>
<dt>Expression</dt>
<dd>Broad expression in spleen (RPKM 16.5), appendix (RPKM 13.6) and 23 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="/gene/4600/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/4600/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/4600/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
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<div class="rprt-section gene-genomic-context">
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<div class="gc_cont">
<div class="gt_cont_contents">
<div style="float:right"><span>See MX2 in </span><a href="/genome/gdv/?context=gene&amp;acc=4600" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">21q22.3</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>18</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=4600&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>21</td>
<td>NC_000021.9 (41362027..41409393) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=4600&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>21</td>
<td>NC_060945.1 (39750638..39798083) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=4600&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>21</td>
<td>NC_000021.8 (42733954..42781320) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 21 - NC_000021.9</strong><img usemap="#nbrMap4600_568815577" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=4600&amp;nuc_gi=568815577&amp;n0=BACE2&amp;n1=PLAC4&amp;n2=LOC127894702&amp;n3=LOC127894703&amp;n4=LOC127894704&amp;n5=LOC127894705&amp;n6=LOC129664735&amp;n7=LOC127894706&amp;n8=LOC126653380&amp;n9=LOC127894707&amp;n10=LOC127894708&amp;n11=LOC127894709&amp;n12=FAM3B&amp;n13=LOC130066691&amp;n14=LOC127894710&amp;n15=LOC130066692&amp;n16=LOC130066693&amp;n17=MX2&amp;n18=LOC130066694&amp;n19=LOC130066695&amp;n20=LOC127894711&amp;n21=LOC130066696&amp;n22=LOC127894712&amp;n23=LOC127894713&amp;n24=LOC128772427&amp;n25=LOC128849172&amp;n26=LOC127894714&amp;n27=LOC127894715&amp;n28=LOC130066697&amp;n29=MX1&amp;n30=LOC130066698&amp;n31=LOC130066699&amp;n32=LOC130066700&amp;n33=LOC126653381&amp;n34=LOC127894716&amp;n35=LOC130066701&amp;n36=LOC130066702&amp;n37=TMPRSS2&amp;n38=LOC127894717&amp;n39=LOC127894718&amp;n40=LOC111099027&amp;n41=LOC117134604" /><map name="nbrMap4600_568815577" id="nbrMap4600_568815577">
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:42551642-42552451')" onMouseOut="hidetip()" coords="14,23,84,31" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:42551642-42552451" href="/gene/127894702" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42572358-42572858')" onMouseOut="hidetip()" coords="36,35,106,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42572358-42572858" href="/gene/127894703" />
<area shape="rect" onMouseOver="showtip(this,event,'beta-secretase 2')" onMouseOut="hidetip()" coords="37,47,184,55" alt="Neighboring gene beta-secretase 2" href="/gene/25825" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42572859-42573359')" onMouseOut="hidetip()" coords="37,59,107,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42572859-42573359" href="/gene/127894704" />
<area shape="rect" onMouseOver="showtip(this,event,'placenta enriched 4')" onMouseOut="hidetip()" coords="44,71,82,79" alt="Neighboring gene placenta enriched 4" href="/gene/191585" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42594561-42595060')" onMouseOut="hidetip()" coords="59,83,129,91" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42594561-42595060" href="/gene/127894705" />
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr21:42612073-42612217')" onMouseOut="hidetip()" coords="78,95,148,103" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr21:42612073-42612217" href="/gene/129664735" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG hESC enhancer GRCh37_chr21:42616252-42616757')" onMouseOut="hidetip()" coords="82,107,152,115" alt="Neighboring gene NANOG hESC enhancer GRCh37_chr21:42616252-42616757" href="/gene/127894706" />
<area shape="rect" onMouseOver="showtip(this,event,'CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:42646500-42647699')" onMouseOut="hidetip()" coords="114,23,184,31" alt="Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:42646500-42647699" href="/gene/126653380" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42651763-42652318')" onMouseOut="hidetip()" coords="120,35,190,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42651763-42652318" href="/gene/127894707" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42652319-42652873')" onMouseOut="hidetip()" coords="120,59,190,67" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42652319-42652873" href="/gene/127894708" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42661864-42662364')" onMouseOut="hidetip()" coords="130,71,200,79" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42661864-42662364" href="/gene/127894709" />
<area shape="rect" onMouseOver="showtip(this,event,'FAM3 metabolism regulating signaling molecule B')" onMouseOut="hidetip()" coords="180,83,264,91" alt="Neighboring gene FAM3 metabolism regulating signaling molecule B" href="/gene/54097" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18470')" onMouseOut="hidetip()" coords="202,23,272,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18470" href="/gene/130066691" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:42731293-42732096')" onMouseOut="hidetip()" coords="203,35,273,43" alt="Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:42731293-42732096" href="/gene/127894710" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18471')" onMouseOut="hidetip()" coords="206,47,276,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18471" href="/gene/130066692" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18472')" onMouseOut="hidetip()" coords="206,59,276,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18472" href="/gene/130066693" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 13330')" onMouseOut="hidetip()" coords="209,71,279,79" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13330" href="/gene/130066694" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18473')" onMouseOut="hidetip()" coords="212,95,282,103" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18473" href="/gene/130066695" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42739613-42740114')" onMouseOut="hidetip()" coords="212,107,282,115" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42739613-42740114" href="/gene/127894711" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42740714-42741402')" onMouseOut="hidetip()" coords="213,119,283,127" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42740714-42741402" href="/gene/127894712" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18474')" onMouseOut="hidetip()" coords="213,131,283,139" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18474" href="/gene/130066696" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42741403-42742089')" onMouseOut="hidetip()" coords="214,143,284,151" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42741403-42742089" href="/gene/127894713" />
<area shape="rect" onMouseOver="showtip(this,event,'melanoma risk locus-associated MPRA allelic enhancer 21:42745414')" onMouseOut="hidetip()" coords="218,155,288,163" alt="Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 21:42745414" href="/gene/128772427" />
<area shape="rect" onMouseOver="showtip(this,event,'melanoma risk locus-associated MPRA allelic enhancers 21:42746568 and 21:42746578')" onMouseOut="hidetip()" coords="219,167,289,175" alt="Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 21:42746568 and 21:42746578" href="/gene/128849172" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42750497-42750998')" onMouseOut="hidetip()" coords="224,179,294,187" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42750497-42750998" href="/gene/127894714" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42750999-42751498')" onMouseOut="hidetip()" coords="224,191,294,199" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42750999-42751498" href="/gene/127894715" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 13332')" onMouseOut="hidetip()" coords="267,83,337,91" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13332" href="/gene/130066697" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18477')" onMouseOut="hidetip()" coords="273,23,343,31" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18477" href="/gene/130066698" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18479')" onMouseOut="hidetip()" coords="280,35,350,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18479" href="/gene/130066700" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18478')" onMouseOut="hidetip()" coords="280,47,350,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18478" href="/gene/130066699" />
<area shape="rect" onMouseOver="showtip(this,event,'CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:42824122-42825321')" onMouseOut="hidetip()" coords="301,59,371,67" alt="Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:42824122-42825321" href="/gene/126653381" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42830117-42830618')" onMouseOut="hidetip()" coords="307,71,377,79" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42830117-42830618" href="/gene/127894716" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18480')" onMouseOut="hidetip()" coords="309,95,379,103" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18480" href="/gene/130066701" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 18481')" onMouseOut="hidetip()" coords="310,107,380,115" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18481" href="/gene/130066702" />
<area shape="rect" onMouseOver="showtip(this,event,'MX dynamin like GTPase 1')" onMouseOut="hidetip()" coords="313,119,370,127" alt="Neighboring gene MX dynamin like GTPase 1" href="/gene/4599" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42851654-42852154')" onMouseOut="hidetip()" coords="330,131,400,139" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42851654-42852154" href="/gene/127894717" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr21:42852155-42852655')" onMouseOut="hidetip()" coords="331,143,401,151" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42852155-42852655" href="/gene/127894718" />
<area shape="rect" onMouseOver="showtip(this,event,'transmembrane protease serine 2 breakpoint cluster recombination region')" onMouseOut="hidetip()" coords="336,155,421,163" alt="Neighboring gene transmembrane protease serine 2 breakpoint cluster recombination region" href="/gene/111099027" />
<area shape="rect" onMouseOver="showtip(this,event,'transmembrane serine protease 2')" onMouseOut="hidetip()" coords="339,83,422,91" alt="Neighboring gene transmembrane serine protease 2" href="/gene/7113" />
<area shape="rect" onMouseOver="showtip(this,event,'TMPRSS2 promoter region')" onMouseOut="hidetip()" coords="353,23,423,31" alt="Neighboring gene TMPRSS2 promoter region" href="/gene/117134604" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="4600">
<option value="NC_000021.9_41362026_41409392">NC_000021.9 Chromosome 21 Reference GRCh38.p14 Primary Assembly</option>
<option value="NC_060945.1_39750637_39798082">NC_060945.1 Chromosome 21 Alternate T2T-CHM13v2.0</option>
<option value="NC_000021.8_42733953_42781319">NC_000021.8 Chromosome 21 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000021" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000021.9?report=graph&amp;from=41354921&amp;to=41416497&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_000021.9">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000021.9?report=fasta&amp;from=41362027&amp;to=41409393" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_000021.9">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000021.9?report=genbank&amp;from=41362027&amp;to=41409393" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_000021.9">GenBank</a>
</p>
<div id="divNC_000021" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000021.9&amp;from=41354921&amp;to=41416497&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000021.9&amp;from=41354921&amp;to=41416497&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000021.9" sid="1" type="hidden" id="nucleotideLink_NC_000021_9_41362026_41409392" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000021.9?report=graph&amp;amp;from=41354921&amp;amp;to=41416497&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_000021.9&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000021.9?report=fasta&amp;amp;from=41362027&amp;amp;to=41409393&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_000021.9&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000021.9?report=genbank&amp;amp;from=41362027&amp;amp;to=41409393&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_000021.9&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000021.9" sid="1" type="hidden" id="relString_NC_000021_9_41362026_41409392" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000021.9&amp;amp;from=41354921&amp;amp;to=41416497&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060945.1" sid="1" type="hidden" id="nucleotideLink_NC_060945_1_39750637_39798082" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060945.1?report=graph&amp;amp;from=39743520&amp;amp;to=39805199&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_060945.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060945.1?report=fasta&amp;amp;from=39750638&amp;amp;to=39798083&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_060945.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060945.1?report=genbank&amp;amp;from=39750638&amp;amp;to=39798083&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_060945.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060945.1" sid="1" type="hidden" id="relString_NC_060945_1_39750637_39798082" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060945.1&amp;amp;from=39743520&amp;amp;to=39805199&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000021.8" sid="1" type="hidden" id="nucleotideLink_NC_000021_8_42733953_42781319" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000021.8?report=graph&amp;amp;from=42726848&amp;amp;to=42788424&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_000021.8&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000021.8?report=fasta&amp;amp;from=42733954&amp;amp;to=42781320&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_000021.8&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000021.8?report=genbank&amp;amp;from=42733954&amp;amp;to=42781320&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=4600&amp;amp;link_uid=NC_000021.8&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000021.8" sid="1" type="hidden" id="relString_NC_000021_8_42733953_42781319" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000021.8&amp;amp;from=42726848&amp;amp;to=42788424&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/4600/?report=expression" data-url="/gene/4600/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/4600" data-report-type="summary">
<div>
<script type="text/javascript">
window.tissues_data = {'adrenal 10wk': {'id': '4600_Adrenal_10wk_PRJNA270632', 'gene': 4600, 'source_name': 'adrenal 10wk', 'full_rpkm': 0.0163451, 'exp_rpkm': 0.0163, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397989748771}, 'adrenal 16wk': {'id': '4600_Adrenal_16wk_PRJNA270632', 'gene': 4600, 'source_name': 'adrenal 16wk', 'full_rpkm': 0.044917, 'exp_rpkm': 0.0449, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397989748772}, 'adrenal 18wk': {'id': '4600_Adrenal_18wk_PRJNA270632', 'gene': 4600, 'source_name': 'adrenal 18wk', 'full_rpkm': 0.059189, 'exp_rpkm': 0.0592, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397989748773}, 'adrenal 20wk': {'id': '4600_Adrenal_20wk_PRJNA270632', 'gene': 4600, 'source_name': 'adrenal 20wk', 'full_rpkm': 0.0580774, 'exp_rpkm': 0.0581, 'var': 0.00096021, 'project_desc': 'PRJNA270632', '_version_': 1785734397989748774}, 'heart 10wk': {'id': '4600_Heart_10wk;_PRJNA270632', 'gene': 4600, 'source_name': 'heart 10wk', 'full_rpkm': 0.0106499, 'exp_rpkm': 0.0106, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797312}, 'heart 11wk': {'id': '4600_Heart_11wk;_PRJNA270632', 'gene': 4600, 'source_name': 'heart 11wk', 'full_rpkm': 0.134906, 'exp_rpkm': 0.135, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797313}, 'heart 17wk': {'id': '4600_Heart_17wk;_PRJNA270632', 'gene': 4600, 'source_name': 'heart 17wk', 'full_rpkm': 0.0676302, 'exp_rpkm': 0.0676, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797314}, 'heart 18wk': {'id': '4600_Heart_18wk;_PRJNA270632', 'gene': 4600, 'source_name': 'heart 18wk', 'full_rpkm': 0.0834602, 'exp_rpkm': 0.0835, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797315}, 'heart 20wk': {'id': '4600_Heart_20wk_PRJNA270632', 'gene': 4600, 'source_name': 'heart 20wk', 'full_rpkm': 0.0946867, 'exp_rpkm': 0.0947, 'var': 0.001866591, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797316}, 'intestine 10wk': {'id': '4600_Intestine_10wk_PRJNA270632', 'gene': 4600, 'source_name': 'intestine 10wk', 'full_rpkm': 0.0441618, 'exp_rpkm': 0.0442, 'var': 0.000461464, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797317}, 'intestine 11wk': {'id': '4600_Intestine_11wk_PRJNA270632', 'gene': 4600, 'source_name': 'intestine 11wk', 'full_rpkm': 0.0773939, 'exp_rpkm': 0.0774, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797318}, 'intestine 15wk': {'id': '4600_Intestine_15wk_PRJNA270632', 'gene': 4600, 'source_name': 'intestine 15wk', 'full_rpkm': 0.205482, 'exp_rpkm': 0.205, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797319}, 'intestine 17wk': {'id': '4600_Intestine_17wk_PRJNA270632', 'gene': 4600, 'source_name': 'intestine 17wk', 'full_rpkm': 0.241473, 'exp_rpkm': 0.241, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734397990797320}, 'intestine 20wk': {'id': 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<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
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</div>
</div>
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<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
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<span class="pubmed-auth-date"> Kong J, <em>et al</em>. Future Microbiol, 2016 Aug. PMID 27492442</span>
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<span class="pubmed-auth-date"> Betancor G, <em>et al</em>. Cell Rep, 2019 Nov 12. PMID 31722207, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC7391006/" ref="ordinalpos=0&amp;ncbi_uid=4600&amp;link_uid=PMC7391006">Free PMC Article</a></span></span>
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<span class="pubmed-auth-date"> Juraleviciute M, <em>et al</em>. Pigment Cell Melanoma Res, 2020 May. PMID 31660681, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC7180100/" ref="ordinalpos=0&amp;ncbi_uid=4600&amp;link_uid=PMC7180100">Free PMC Article</a></span></span>
</li>
<li>
<a href="/pubmed/31265172/" ref="ordinalpos=5&amp;ncbi_uid=4600&amp;link_uid=31265172">Overexpression of human MX2 gene suppresses cell proliferation, migration, and invasion via ERK/P38/NF-κB pathway in glioblastoma cells.</a>
<span class="pubmed-auth-date"> Wang H, <em>et al</em>. J Cell Biochem, 2019 Nov. PMID 31265172</span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=4600" title="See all 90 citations in Pubmed">See all (90) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/37796130" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=37796130">A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/36743306" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=36743306">Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.</a>
<div id="gene-popper2" class="gene-rif-popper">Title: Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/35505682" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=35505682">Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/36059547" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=36059547">MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus.</a>
<div id="gene-popper4" class="gene-rif-popper">Title: MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/33933170" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=33933170">The transcriptome profile of human trisomy 21 blood cells.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: The transcriptome profile of human trisomy 21 blood cells.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/34707174" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=34707174">High accumulation of Mx2 renders limited multiplication of oncolytic herpes simplex virus-1 in human tumor cells.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: High accumulation of Mx2 renders limited multiplication of oncolytic herpes simplex virus-1 in human tumor cells.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/31863794" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=31863794">Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/34282309" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=34282309">MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/33734579" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=33734579">MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/32600399" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=32600399">MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=4600&amp;sym=MX2&amp;name=MX dynamin like GTPase 2&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=4600&amp;symbol=MX2;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=4600" class="seeall-generif">See all GeneRIFs (50)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=MX2[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=4600">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
<thead>
<tr>
<th class="description">Description</th>
</tr>
</thead>
<tbody>
<tr>
<td>Genome-wide association study identifies three new melanoma susceptibility loci.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/21983787">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/21983787">PubMed</a></span></div></div></div></td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=MX2[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=4600" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=4600[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=4600[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="replicationinteractions">Replication interactions</h3>
<table summary="replication interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivinter">HIV-1 replication is restricted by functional MX2 (MxB) which is dependent upon amino acid G208 in CA in Cf2Th and THP-1 cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26719253" href="/pubmed/26719253">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 replication is inhibited by wild type MX2 (MxB) but not when mutations in the stalk oligomerization interfaces, hinge region, or L4 loop are made</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26446602" href="/pubmed/26446602">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 replication is restricted by wild type MX2 (MxB); restriction is dependent on amino acids M574, Y651, and F647 in MX2 as assayed in U87-MG CD4+ CXCR4+ cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 27375111" href="/pubmed/27375111">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 replication is NOT restricted by MX2 (MxB) mutants M574D, Y651D and M567D/L570D (mutations affect MX2 dimerization); this observation indicates that MX2 (MxB) dimerization is important for anti-HIV-1 activity in this context</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25312384" href="/pubmed/25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 replication is restricted by MX2 mutants I423D, K663D, M666D, and the I423/K663D double mutant (all interface 1 MX2 (MxB) mutants); indicates that MX2 oligomerization through interface 1 is not critical for MX2-mediated HIV-1 restriction</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25312384" href="/pubmed/25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 replication is restricted by MX2 (MxB) mutants E681A and R689A (in HOS cells), indicating anti-HIV-1 activity of MX2 (MxB) is not dependent on transfer of information from the GTPase domain to the stalk domain</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25312384" href="/pubmed/25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">HIV-1 infection is restricted by wild type MX2 (MxB) and the YRGK487-490AAAA mutant MX2 (MxB)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25312384" href="/pubmed/25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">VSVG-pseudotyped recombinant HIV-1 is restricted by MX2 (MxB) with mutations in interface 1 (E424R, K663D, L669D) just as strongly as wild-type MX2 (MxB)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25568212" href="/pubmed/25568212">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivinter">Knockdown of MX2 by shRNA enhances HIV-1 replication in an IFN-alpha-dependent manner in HIV-1-infected cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24121441,24055605,24048477" href="/pubmed/24121441,24055605,24048477">PubMed</a>
</td>
</tr>
</tbody>
</table>
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120-treated vaginal epithelial cells show upregulation of myxovirus resistance 2 (MX2, MXB) expression as compared to untreated control</td>
<td headers="hivpub">
<a title="PubMed Id(s): 23867815" href="/pubmed/23867815">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629358">Tat</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 and the viral protein Tat modulate the expression of MX dynamin-like GTPase 2 (MX2; MxB) in immature dendritic cells and monocyte-derived macrophages</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24742347" href="/pubmed/24742347">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872817">Vpr</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">HIV-1 Vpr upregulates the gene expression of MX2 in human monocyte-derived macrophages</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26116899,25170834" href="/pubmed/26116899,25170834">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">HIV-1 Vpr upregulates the gene expression of MX2 in human monocyte-derived dendritic cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26116899" href="/pubmed/26116899">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/19172948">capsid</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA binds MX2 (MxB) dependent upon G208 in CA, which is not related to IFN-alpha restriction in THP-1, HT-1080, and U87 MG cell lines</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26719253" href="/pubmed/26719253">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA H87P, G116A, and P207A mutants are resistant to inhibition by MX2 (MxB), but still interact with MX2 (MxB)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 27428433" href="/pubmed/27428433">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">CA-NC complex/core (in vitro-assembled from HIV-1 NL4-3 Gag amino acids 133-433; fusion protein) DOES NOT bind to MX2 (MxB) with mutations in interface 2 (Q644D, M574D, Y651D and M574D/Y651D, each preventing MX2 oligomerization)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25568212" href="/pubmed/25568212">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">CA binding to MX2 (MxB) involves the N-terminal 25 amino acids of MX2 (MxB)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26063425,25312384" href="/pubmed/26063425,25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Anti-HIV-1 activity of MX2 is greatly enhanced when MX2 is directly targeted to HIV-1 CA by fusion with PPIA (CypA)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25036886,24760893,24559861,24055605" href="/pubmed/25036886,24760893,24559861,24055605">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">CA-NC complex/core (in vitro-assembled from HIV-1 NL4-3 Gag amino acids 133-433; fusion protein) binds to MX2 (MxB) with mutations in interface 1 (E424R, K663D, L669D) as strongly as wild-type MX2 (MxB)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25568212" href="/pubmed/25568212">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Disruption of the leucine zipper by a single point mutation L661K abolishes the ability of MX2 to oligomerize, leading to neither binding to in vitro assembled HIV-1 CA-NC complexes nor restrict HIV-1 infection</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25568212,25123063" href="/pubmed/25568212,25123063">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">MX2 binds to in vitro assembled HIV-2 and SIVmac CA-NC complexes</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25123063" href="/pubmed/25123063">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA tubes bind MX2 (MxB) directly in vitro, indicating that cellular cofactors are not required for the direct interaction of these two proteins</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25363729,25312384" href="/pubmed/25363729,25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">WT CA binds MX2 (MX2-HA) efficiently as well as interface 1 mutants K663D, I423D/K663D, and M666D; hinge 1 mutant E681A and interface 2 mutants M574D and Y651D do not bind CA efficiently</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25312384" href="/pubmed/25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA in assembled lattices bind MX2, but not single CA hexamers (pentamers or monomers)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25363729,25312384" href="/pubmed/25363729,25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA binds MBP-MX2-YRGK/IKM directly, indicating that cellular cofactors are not required for the binding between CA and MX2</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25312384" href="/pubmed/25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA-MX2 interaction plays a role in in restriction of HIV-1 replication (negative correlation of CA-MX2 binding scatterplot analysis yields a Spearman rank correlation coefficient p value of 0.028)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25312384" href="/pubmed/25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Efficient HIV-1 CA binding to MX2 requires the first 84 amino acids of MX2 (N-terminus)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25363729,25312384" href="/pubmed/25363729,25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">CA/MX2 (MxB) binding requires an intact 'RRR' motif located at amino acids 11-13 in the N-terminal of MX2 (MxB)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 26063425" href="/pubmed/26063425">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">MX2 binds to the HIV-1 core and inhibits the uncoating process of HIV-1 during infection, which is prevented by a benzimidazole-based inhibitor that binds to a specific pocket in the HIV-1 capsid</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25731773,25123063" href="/pubmed/25731773,25123063">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA N57S, K70R, N74D, A88T, G89V, P90A, and T107N mutants are resistant to inhibition by MX2, suggesting that CA is a specific target of MX2</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25731773,25348155,25312384,25123063,25036886,24760893,24559861,24139395,24121441,24055605,24048477" href="/pubmed/25731773,25348155,25312384,25123063,25036886,24760893,24559861,24139395,24121441,24055605,24048477">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA mutants V86A, V86Q, H87P, H87Q, A88V, and A92P in the cyclophilin A-binding loop of CA are resistant to MxB restriction</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25571928" href="/pubmed/25571928">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA mutants E45A, N57A, N57S, K70R, G89V, and T107N are significantly less sensitive than the wild-type to MxB restriction</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25348155" href="/pubmed/25348155">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">MX2 binds to in vitro assembled HIV-1 CA-NC complexes, whereas MX1 is not able to interact with in vitro assembled HIV-1 CA-NC complexes</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25568212,25123063" href="/pubmed/25568212,25123063">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">MX2 co-localizes with HIV-1 CA, suggesting that MX2 directly associates with HIV-1 cores in living cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25123063" href="/pubmed/25123063">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">A protein chimera MX2(1-90)-MX1(43-662) has the ability to bind in vitro assembled HIV-1 CA-NC complexes, suggesting that the N-terminal region (residues 1-90) of MX2 is involved in its ability to bind capsid</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25123063" href="/pubmed/25123063">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">The cryo-EM images show distinct protein densities decorating the HIV-1 CA tubes in the presence of MX2 compared to MX2(84-715) mutant, confirming both direct protein binding and the importance of the MX2 N terminus in this interaction</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25312384" href="/pubmed/25312384">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA mutants M10I, N57S, H87R, P90T, Q95L, M185I, P207S, G208R, and T210K are entirely or partially resistant to human MX2</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24760893" href="/pubmed/24760893">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/25121908">integrase</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155348">gag-pol</a>
</td>
<td headers="hivinter">HIV-1 IN mutant D64N/D116N is significantly more resistant than the wild-type and D167K IN mutant to MxB restriction</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25348155" href="/pubmed/25348155">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/19172949">nucleocapsid</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">CA-NC complex/core (in vitro-assembled from HIV-1 NL4-3 Gag amino acids 133-433; fusion protein) DOES NOT bind to MX2 (MxB) with the L661K mutation (prevents oligomerization) in the putative leucine zipper region</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25568212" href="/pubmed/25568212">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">CA-NC complex/core (in vitro-assembled from HIV-1 NL4-3 Gag amino acids 133-433; fusion protein) DOES NOT bind to MX2 (MxB) with mutations in interface 2 (Q644D, M574D, Y651D and M574D/Y651D, each preventing MX2 oligomerization)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25568212" href="/pubmed/25568212">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">CA-NC complexes (in vitro-assembled from HIV-1 NL4-3 Gag amino acids 133-433; fusion protein) bind to MX2 (MxB) with mutations in interface 1 (E424R, K663D, L669D) as strongly as wild-type MX2 (MxB)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25568212" href="/pubmed/25568212">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/4600#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/4600/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">GDB:191983 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=155656%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=155656">UniSTS:155656</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">MX2_216 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=277515%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=277515">UniSTS:277515</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">PMC310729P7 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=272656%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=272656">UniSTS:272656</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">MX1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=506212%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=506212">UniSTS:506212</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D21S1826 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=64701%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=64701">UniSTS:64701</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G34721 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=64702%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=64702">UniSTS:64702</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">STS-M30818 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=73936%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=73936">UniSTS:73936</a></li></ul></li>
</ul>
</div>
</div>
<div></div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/4600/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="infosec info-comment" id="info-comment">
<h3 id="CloneNames">
<a class="jig-ncbitoggler-open">Clone Names</a>
</h3>
<ul class="geneinfo-subsec">
<li>FLJ44119 </li>
</ul>
</div>
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005525">enables GTP binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/15184662" target="_blank" title="PubMed ID 15184662" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=15184662">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0003924">enables GTPase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-2-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008017">enables microtubule binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-3-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-4-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/25416956,32296183" target="_blank" title="PubMed ID 25416956,32296183" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=25416956,32296183">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006952">involved_in defense response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-1-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8798556" target="_blank" title="PubMed ID 8798556" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=8798556">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051607">involved_in defense response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051607">involved_in defense response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24121441" target="_blank" title="PubMed ID 24121441" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=24121441">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045087">involved_in innate immune response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051028">involved_in mRNA transport</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-5-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0015031">involved_in protein transport</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-6-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031623">involved_in receptor internalization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051726">involved_in regulation of cell cycle</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15184662" target="_blank" title="PubMed ID 15184662" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=15184662">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0046822">involved_in regulation of nucleocytoplasmic transport</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-9-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15184662" target="_blank" title="PubMed ID 15184662" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=15184662">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035455">involved_in response to interferon-alpha</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24121441" target="_blank" title="PubMed ID 24121441" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=24121441">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0009615">involved_in response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-11-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24048477" target="_blank" title="PubMed ID 24048477" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=24048477">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016185">involved_in synaptic vesicle budding from presynaptic endocytic zone membrane</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-12-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">is_active_in cytoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-2-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005874">is_active_in microtubule</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005643">part_of nuclear pore</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/15184662" target="_blank" title="PubMed ID 15184662" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=15184662">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">is_active_in nucleus</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-5-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">is_active_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-6-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098793">located_in presynapse</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-7-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045202">is_active_in synapse</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-8-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>interferon-induced GTP-binding protein Mx2</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>interferon-regulated resistance GTP-binding protein MXB</dd>
<dd>myxovirus (influenza virus) resistance 2</dd>
<dd>myxovirus resistance protein 2</dd>
<dd>p78-related protein</dd>
<dd>second interferon-induced protein p78</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=4600&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="mrnaandproteins-p140356544">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_002463.2">NM_002463.2</a><a href="/protein/NP_002454.1">NP_002454.1</a>  interferon-induced GTP-binding protein Mx2</p>
<p>
<a href="/ipg/NP_002454.1/" ref="ncbi_uid=4600">See identical proteins and their annotated locations for NP_002454.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AL773578, M30818">AL773578, M30818</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS13672.1">CCDS13672.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000333657.3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">ENSP00000333657.3</a>, <a href="http://www.ensembl.org/id/ENST00000330714.8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">ENST00000330714.8</a></dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_002454.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=128597">smart00302</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">621</span><span class="cddto">709</span></dt>
<dd class="clearfix"> GED; Dynamin GTPase effector domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=206738">cd08771</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">116</span><span class="cddto">387</span></dt>
<dd class="clearfix"> DLP_1; Dynamin_like protein family includes dynamins and Mx proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=307257">pfam01031</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">307</span><span class="cddto">593</span></dt>
<dd class="clearfix"> Dynamin_M; Dynamin central region</dd>
</dl>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p185322224">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p185322224">Genomic </h4>
<ol>
<li>
<p>NC_000021.9 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>41362027..41409393</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000021.9?from=41362027&amp;to=41409393&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_000021.9?from=41362027&amp;to=41409393&amp;report=genbank">GenBank</a>, <a href="/nuccore/NC_000021.9?from=41362027&amp;to=41409393&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_000021.9?from=41362027&amp;to=41409393&amp;report=fasta">FASTA</a>, <a href="/nuccore/NC_000021.9?from=41354921&amp;to=41416497&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_000021.9?from=41354921&amp;to=41416497&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p26038784">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_011529573.3">XM_011529573.3</a><a href="/protein/XP_011527875.1">XP_011527875.1</a>  interferon-induced GTP-binding protein Mx2 isoform X2</p>
<dl>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011527875.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=128597">smart00302</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">576</span><span class="cddto">664</span></dt>
<dd class="clearfix"> GED; Dynamin GTPase effector domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=206738">cd08771</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">116</span><span class="cddto">342</span></dt>
<dd class="clearfix"> DLP_1; Dynamin_like protein family includes dynamins and Mx proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279383">pfam01031</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">263</span><span class="cddto">549</span></dt>
<dd class="clearfix"> Dynamin_M; Dynamin central region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_024452080.2">XM_024452080.2</a><a href="/protein/XP_024307848.1">XP_024307848.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_024307848.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=128597">smart00302</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">621</span><span class="cddto">709</span></dt>
<dd class="clearfix"> GED; Dynamin GTPase effector domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=206738">cd08771</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">116</span><span class="cddto">387</span></dt>
<dd class="clearfix"> DLP_1; Dynamin_like protein family includes dynamins and Mx proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=307257">pfam01031</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">307</span><span class="cddto">593</span></dt>
<dd class="clearfix"> Dynamin_M; Dynamin central region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047440780.1">XM_047440780.1</a><a href="/protein/XP_047296736.1">XP_047296736.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047440779.1">XM_047440779.1</a><a href="/protein/XP_047296735.1">XP_047296735.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_005260983.6">XM_005260983.6</a><a href="/protein/XP_005261040.1">XP_005261040.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<p>
<a href="/ipg/XP_005261040.1/" ref="ncbi_uid=4600">See identical proteins and their annotated locations for XP_005261040.1</a>
</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000506423.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">ENSP00000506423.1</a>, <a href="http://www.ensembl.org/id/ENST00000680862.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">ENST00000680862.1</a></dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_005261040.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=128597">smart00302</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">621</span><span class="cddto">709</span></dt>
<dd class="clearfix"> GED; Dynamin GTPase effector domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=206738">cd08771</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">116</span><span class="cddto">387</span></dt>
<dd class="clearfix"> DLP_1; Dynamin_like protein family includes dynamins and Mx proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=307257">pfam01031</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">307</span><span class="cddto">593</span></dt>
<dd class="clearfix"> Dynamin_M; Dynamin central region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047440781.1">XM_047440781.1</a><a href="/protein/XP_047296737.1">XP_047296737.1</a>  interferon-induced GTP-binding protein Mx2 isoform X2</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_005260984.2">XM_005260984.2</a><a href="/protein/XP_005261041.1">XP_005261041.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<p>
<a href="/ipg/XP_005261041.1/" ref="ncbi_uid=4600">See identical proteins and their annotated locations for XP_005261041.1</a>
</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_005261041.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=128597">smart00302</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">621</span><span class="cddto">709</span></dt>
<dd class="clearfix"> GED; Dynamin GTPase effector domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=206738">cd08771</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">116</span><span class="cddto">387</span></dt>
<dd class="clearfix"> DLP_1; Dynamin_like protein family includes dynamins and Mx proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=307257">pfam01031</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">307</span><span class="cddto">593</span></dt>
<dd class="clearfix"> Dynamin_M; Dynamin central region</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047440782.1">XM_047440782.1</a><a href="/protein/XP_047296738.1">XP_047296738.1</a>  interferon-induced GTP-binding protein Mx2 isoform X2</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_047440783.1">XM_047440783.1</a><a href="/protein/XP_047296739.1">XP_047296739.1</a>  interferon-induced GTP-binding protein Mx2 isoform X2</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_011529572.3">XM_011529572.3</a><a href="/protein/XP_011527874.1">XP_011527874.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<p>
<a href="/ipg/XP_011527874.1/" ref="ncbi_uid=4600">See identical proteins and their annotated locations for XP_011527874.1</a>
</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011527874.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=128597">smart00302</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">621</span><span class="cddto">709</span></dt>
<dd class="clearfix"> GED; Dynamin GTPase effector domain</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=206738">cd08771</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">116</span><span class="cddto">387</span></dt>
<dd class="clearfix"> DLP_1; Dynamin_like protein family includes dynamins and Mx proteins</dd>
</dl>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=307257">pfam01031</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">307</span><span class="cddto">593</span></dt>
<dd class="clearfix"> Dynamin_M; Dynamin central region</dd>
</dl>
</dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p46260640">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p46260640">Genomic </h4>
<ol>
<li>
<p>NC_060945.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>39750638..39798083</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060945.1?from=39750638&amp;to=39798083&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_060945.1?from=39750638&amp;to=39798083&amp;report=genbank">GenBank</a>, <a href="/nuccore/NC_060945.1?from=39750638&amp;to=39798083&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_060945.1?from=39750638&amp;to=39798083&amp;report=fasta">FASTA</a>, <a href="/nuccore/NC_060945.1?from=39743520&amp;to=39805199&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=NC_060945.1?from=39743520&amp;to=39805199&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p185344032">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_054324511.1">XM_054324511.1</a><a href="/protein/XP_054180486.1">XP_054180486.1</a>  interferon-induced GTP-binding protein Mx2 isoform X2</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_054324508.1">XM_054324508.1</a><a href="/protein/XP_054180483.1">XP_054180483.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054324509.1">XM_054324509.1</a><a href="/protein/XP_054180484.1">XP_054180484.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054324504.1">XM_054324504.1</a><a href="/protein/XP_054180479.1">XP_054180479.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054324510.1">XM_054324510.1</a><a href="/protein/XP_054180485.1">XP_054180485.1</a>  interferon-induced GTP-binding protein Mx2 isoform X2</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_054324507.1">XM_054324507.1</a><a href="/protein/XP_054180482.1">XP_054180482.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054324505.1">XM_054324505.1</a><a href="/protein/XP_054180480.1">XP_054180480.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054324512.1">XM_054324512.1</a><a href="/protein/XP_054180487.1">XP_054180487.1</a>  interferon-induced GTP-binding protein Mx2 isoform X2</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_054324513.1">XM_054324513.1</a><a href="/protein/XP_054180488.1">XP_054180488.1</a>  interferon-induced GTP-binding protein Mx2 isoform X2</p>
<dl></dl>
</li>
<li>
<p><a href="/nuccore/XM_054324506.1">XM_054324506.1</a><a href="/protein/XP_054180481.1">XP_054180481.1</a>  interferon-induced GTP-binding protein Mx2 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B7Z5D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">B7Z5D3</a>, <a href="https://www.uniprot.org/uniprot/D3DSI7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">D3DSI7</a>, <a href="https://www.uniprot.org/uniprot/P20592" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=4600&amp;nlmid=&amp;db=gene">P20592</a></dd>
</dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/4600/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">P20592.1</td>
<td headers="rs-link rs-genepept">
<a href="/protein/127571" ref="ordinalpos=1&amp;ncbi_uid=4600&amp;link_uid=127571">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/P20592">UniProtKB/Swiss-Prot:P20592</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/MX2?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>Mx2 products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000183486" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>MX2 gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/4600/" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (12 hits/1363 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>MX2</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=MX2_1" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>MX2_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/P20592" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&amp;modeInput=Absolute&amp;primaryGene=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D4600%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=3922" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000183486" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN58697/" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/MX2" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=MX2" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for MX2</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/mx2/lysates?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=lysates" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>MX2 Lysates</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/mx2/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>MX2 Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/mx2/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>MX2 Proteins</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Creative Biogene</li>
<ul>
<li>
<a target="_blank" href="https://www.creative-biogene.com/genesearch/Mx2.html" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10094">
<span>myxovirus (influenza virus) resistance 2 (mouse)</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/MX2-antibody.html" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/MX2-antibody.html" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&amp;field=5&amp;key=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order TALEN/CRISPR clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&amp;field=5&amp;prt=16&amp;key=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order miRNA target clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=MX2;" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=MX2" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order MX2 cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=4600" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open">
<span>Miscellaneous</span>
</a>
<ul>
<li><span class="free-rsc"></span>Reactome</li>
<ul>
<li>
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:P20592" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Entity:P20592</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-168256" ref="itool=Gene_FullReport&amp;uid=4600&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Immune System</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
<div id="urls-in-genombrowser" style="display:none">
</div>
</div>
</div>
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<!-- sidebar close/hide button-->
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#CloneNames">Clone Names</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
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</li>
</ul>
</div>
</div>
<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
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</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/4600" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=4600" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=4600" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=4600" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=4600" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=4600" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=4600" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=4600" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=4600" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=4600" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=4600" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=4600" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=4600" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=4600" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=4600" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=4600" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=4600[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=4600" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=4600" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=4600" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=4600" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=4600" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=4600" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=4600" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=4600" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=4600" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=4600" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=4600" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=4600" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=4600" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=4600" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=4600" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=4600[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
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<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
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</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7533">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000183486">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:7533">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=4600">AceView</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_002463">UCSC</a>
</li>
<li>
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC035293">MGC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=MX2&amp;geneID=4600&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:4600">KEGG</a>
</li>
<li>
<a href="https://reactome.org/content/query?q=UniProt:P20592">Reactome</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
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<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
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<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
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<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=4600&amp;symbol=MX2">Submit Correction</a>
</li>
<li>
<a href="/gene/submit-generif?geneId=4600&amp;sym=MX2&amp;name=MX dynamin like GTPase 2&amp;org=Homo sapiens">Submit GeneRIF</a>
</li>
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<h3>Subscription</h3>
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<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
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<ul id="activity">
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9e248a68b6b5afc7ccada">MX2 MX dynamin like GTPase 2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">MX2 MX dynamin like GTPase 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4600</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9e246b15b832ebc17ff72">interferon-induced GTP-binding protein Mx2 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">interferon-induced GTP-binding protein Mx2 [Homo sapiens]<div class="brieflinkpopdesc">gi|11342664|ref|NP_002454.1|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9e24384f3725e5945cf52">MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:727897</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9e24184f3725e5945c47b">mucin-5B precursor [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">mucin-5B precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|301172750|ref|NP_002449.2|</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9e23e84f3725e5945aece">MTOR mechanistic target of rapamycin kinase [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">MTOR mechanistic target of rapamycin kinase [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:2475</div></div>
<div class="tertiary">Gene</div>
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