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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'3460',linkname:'',idsfromresult:'3458',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li><li class="fil_val"><a href="#" data-value_id="seq-refseqgene">RefSeqGene</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9df5469195c35ad6d84db" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="3460" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">IFNG</span> interferon gamma [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 3458, updated on
4-Mar-2025</span>
</div>
<div class="download-datasets">
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<a href="#">Download Datasets</a>
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<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
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<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
<div class="input-group">
<label for="datasets-download-file-name">File name</label>
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="IFNG_datasets.zip" />
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<div class="rprt-body">
<div class="rprt-section gene-summary">
<section class="rprt-section-header" id="summary">
<h2 id="header-summary">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Summary</span>
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</section>
<div class="rprt-section-body">
<div id="summaryDiv" class="section">
<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">IFNG<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>interferon gamma<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5438" data-gblink-text="Ensembl">HGNC:HGNC:5438</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000111537" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000111537">Ensembl:ENSG00000111537</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/147570" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=147570">MIM:147570;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:5438" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=HGNC:5438">AllianceGenome:HGNC:5438</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>IFG; IFI; IMD69</dd>
<dt>Summary</dt>
<dd>This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]</dd>
<dt>Annotation information</dt>
<dd>Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.</dd>
<dt>Expression</dt>
<dd>Biased expression in bone marrow (RPKM 3.6), lymph node (RPKM 3.2) and 8 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="https://www.ncbi.nlm.nih.gov/gene/15978">mouse</a>
<a href="/gene/3458/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/3458/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/3458/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
</div>
</div>
</div>
<div class="rprt-section gene-genomic-context">
<section class="rprt-section-header" id="genomic-context">
<h2 id="header-genomic-context">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic context</span>
</a>
</h2>
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</a>
</div>
</section>
<div class="rprt-section-body">
<div class="gc_cont">
<div class="gt_cont_contents">
<div style="float:right"><span>See IFNG in </span><a href="/genome/gdv/?context=gene&amp;acc=3458" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">12q15</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>4</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=3458&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>12</td>
<td>NC_000012.12 (68154768..68159740, complement) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=3458&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>12</td>
<td>NC_060936.1 (68134280..68139252, complement) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=3458&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>12</td>
<td>NC_000012.11 (68548548..68553520, complement) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 12 - NC_000012.12</strong><img usemap="#nbrMap3458_568815586" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=3458&amp;nuc_gi=568815586&amp;n0=HNRNPA1P70&amp;n1=LOC130008260&amp;n2=LOC100509370&amp;n3=IFNG&amp;n4=LOC130008261&amp;n5=LOC105369818&amp;n6=IL26&amp;n7=LOC130008262&amp;n8=IL22" /><map name="nbrMap3458_568815586" id="nbrMap3458_568815586">
<area shape="rect" onMouseOver="showtip(this,event,'heterogeneous nuclear ribonucleoprotein A1 pseudogene 70')" onMouseOut="hidetip()" coords="12,23,72,31" alt="Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 70" href="/gene/341333" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 6631')" onMouseOut="hidetip()" coords="13,35,83,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6631" href="/gene/130008260" />
<area shape="rect" onMouseOver="showtip(this,event,'39S ribosomal protein L21, mitochondrial-like')" onMouseOut="hidetip()" coords="178,23,248,31" alt="Neighboring gene 39S ribosomal protein L21, mitochondrial-like" href="/gene/100509370" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 6632')" onMouseOut="hidetip()" coords="233,35,303,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6632" href="/gene/130008261" />
<area shape="rect" onMouseOver="showtip(this,event,'uncharacterized LOC105369818')" onMouseOut="hidetip()" coords="245,59,337,67" alt="Neighboring gene uncharacterized LOC105369818" href="/gene/105369818" />
<area shape="rect" onMouseOver="showtip(this,event,'interleukin 26')" onMouseOut="hidetip()" coords="315,23,377,31" alt="Neighboring gene interleukin 26" href="/gene/55801" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 6633')" onMouseOut="hidetip()" coords="341,35,411,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6633" href="/gene/130008262" />
<area shape="rect" onMouseOver="showtip(this,event,'interleukin 22')" onMouseOut="hidetip()" coords="392,23,423,31" alt="Neighboring gene interleukin 22" href="/gene/50616" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
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</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="3458">
<option value="NC_000012.12_68154767_68159739">NC_000012.12 Chromosome 12 Reference GRCh38.p14 Primary Assembly</option>
<option value="NG_015840.1_5001_9973">NG_015840.1 RefSeqGene</option>
<option value="NC_060936.1_68134279_68139251">NC_060936.1 Chromosome 12 Alternate T2T-CHM13v2.0</option>
<option value="NC_000012.11_68548547_68553519">NC_000012.11 Chromosome 12 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000012" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000012.12?report=graph&amp;from=68154021&amp;to=68160485&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_000012.12">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000012.12?report=fasta&amp;from=68154768&amp;to=68159740&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_000012.12">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000012.12?report=genbank&amp;from=68154768&amp;to=68159740&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_000012.12">GenBank</a>
</p>
<div id="divNC_000012" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000012.12&amp;from=68154021&amp;to=68160485&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000012.12&amp;from=68154021&amp;to=68160485&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000012.12" sid="1" type="hidden" id="nucleotideLink_NC_000012_12_68154767_68159739" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000012.12?report=graph&amp;amp;from=68154021&amp;amp;to=68160485&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_000012.12&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000012.12?report=fasta&amp;amp;from=68154768&amp;amp;to=68159740&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_000012.12&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000012.12?report=genbank&amp;amp;from=68154768&amp;amp;to=68159740&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_000012.12&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000012.12" sid="1" type="hidden" id="relString_NC_000012_12_68154767_68159739" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000012.12&amp;amp;from=68154021&amp;amp;to=68160485&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_015840.1" sid="1" type="hidden" id="nucleotideLink_NG_015840_1_5001_9973" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NG_015840.1?report=graph&amp;amp;from=4255&amp;amp;to=10719&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NG_015840.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NG_015840.1?report=fasta&amp;amp;from=5002&amp;amp;to=9974&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NG_015840.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NG_015840.1?report=genbank&amp;amp;from=5002&amp;amp;to=9974&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NG_015840.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_015840.1" sid="1" type="hidden" id="relString_NG_015840_1_5001_9973" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NG_015840.1&amp;amp;from=4255&amp;amp;to=10719&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060936.1" sid="1" type="hidden" id="nucleotideLink_NC_060936_1_68134279_68139251" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060936.1?report=graph&amp;amp;from=68133533&amp;amp;to=68139997&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_060936.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060936.1?report=fasta&amp;amp;from=68134280&amp;amp;to=68139252&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_060936.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060936.1?report=genbank&amp;amp;from=68134280&amp;amp;to=68139252&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_060936.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060936.1" sid="1" type="hidden" id="relString_NC_060936_1_68134279_68139251" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060936.1&amp;amp;from=68133533&amp;amp;to=68139997&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000012.11" sid="1" type="hidden" id="nucleotideLink_NC_000012_11_68548547_68553519" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000012.11?report=graph&amp;amp;from=68547801&amp;amp;to=68554265&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_000012.11&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000012.11?report=fasta&amp;amp;from=68548548&amp;amp;to=68553520&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_000012.11&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000012.11?report=genbank&amp;amp;from=68548548&amp;amp;to=68553520&amp;amp;strand=true&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=3458&amp;amp;link_uid=NC_000012.11&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000012.11" sid="1" type="hidden" id="relString_NC_000012_11_68548547_68553519" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000012.11&amp;amp;from=68547801&amp;amp;to=68554265&amp;amp;strand=true&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/3458/?report=expression" data-url="/gene/3458/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/3458" data-report-type="summary">
<div>
<script type="text/javascript">
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"gene": 3458, "sample_id": "SAMN03267756", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605205, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 10856.4}, {"id": "metadata_9606_SAMN03267764", "gene": 3458, "sample_id": "SAMN03267764", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605206, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5097.56}, {"id": "metadata_9606_SAMN03267760", "gene": 3458, "sample_id": "SAMN03267760", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605207, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5994.06}], "intestine 10wk": [{"id": "metadata_9606_SAMN03267752", "gene": 3458, "sample_id": "SAMN03267752", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605203, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 7808.8}, {"id": "metadata_9606_SAMN03267759", "gene": 3458, "sample_id": "SAMN03267759", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605204, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 6906.84}], "intestine 11wk": [{"id": "metadata_9606_SAMN03267758", "gene": 3458, "sample_id": "SAMN03267758", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605202, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 11wk", "exp_Mcount": 4334.9}], "intestine 15wk": [{"id": "metadata_9606_SAMN03267775", "gene": 3458, "sample_id": "SAMN03267775", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605201, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 15wk", "exp_Mcount": 3980.45}], "intestine 17wk": [{"id": "metadata_9606_SAMN03267782", "gene": 3458, "sample_id": "SAMN03267782", "full_rpkm": 0.0320638, "exp_rpkm": 0.0321, "exp_total": 375, "project_desc": "PRJNA270632", "_version_": 1785734387344605200, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 17wk", "exp_Mcount": 9665.65}], "intestine 20wk": [{"id": "metadata_9606_SAMN03267766", "gene": 3458, "sample_id": "SAMN03267766", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605198, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 4161.26}, {"id": "metadata_9606_SAMN03267769", "gene": 3458, "sample_id": "SAMN03267769", "full_rpkm": 0.109301, "exp_rpkm": 0.109, "exp_total": 515, "project_desc": "PRJNA270632", "_version_": 1785734387344605199, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 3894.01}], "kidney 10wk": [{"id": "metadata_9606_SAMN03267784", "gene": 3458, "sample_id": "SAMN03267784", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605197, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 10wk", "exp_Mcount": 4725.59}], "kidney 16wk": [{"id": "metadata_9606_SAMN03267772", "gene": 3458, "sample_id": "SAMN03267772", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605196, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 16wk", "exp_Mcount": 15288.2}], "kidney 20wk": [{"id": "metadata_9606_SAMN03267777", "gene": 3458, "sample_id": "SAMN03267777", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605195, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 20wk", "exp_Mcount": 10280.0}], "lung 10wk": [{"id": "metadata_9606_SAMN03267770", "gene": 3458, "sample_id": "SAMN03267770", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605193, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5952.75}, {"id": "metadata_9606_SAMN03267767", "gene": 3458, "sample_id": "SAMN03267767", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605194, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5231.26}], "lung 17wk": [{"id": "metadata_9606_SAMN03267778", "gene": 3458, "sample_id": "SAMN03267778", "full_rpkm": 0.0248427, "exp_rpkm": 0.0248, "exp_total": 188, "project_desc": "PRJNA270632", "_version_": 1785734387344605191, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 6254.23}, {"id": "metadata_9606_SAMN03267776", "gene": 3458, "sample_id": "SAMN03267776", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605192, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 3743.33}], "lung 20wk": [{"id": "metadata_9606_SAMN03267780", "gene": 3458, "sample_id": "SAMN03267780", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605189, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 9270.13}, {"id": "metadata_9606_SAMN03267768", "gene": 3458, "sample_id": "SAMN03267768", "full_rpkm": 0.0710329, "exp_rpkm": 0.071, "exp_total": 546, "project_desc": "PRJNA270632", "_version_": 1785734387344605190, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 6352.54}], "stomach 10wk": [{"id": "metadata_9606_SAMN03267773", "gene": 3458, "sample_id": "SAMN03267773", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605187, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 6582.02}, {"id": "metadata_9606_SAMN03267779", "gene": 3458, "sample_id": "SAMN03267779", "full_rpkm": 0.0194216, "exp_rpkm": 0.0194, "exp_total": 170, "project_desc": "PRJNA270632", "_version_": 1785734387344605188, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 7234.02}], "stomach 16wk": [{"id": "metadata_9606_SAMN03267774", "gene": 3458, "sample_id": "SAMN03267774", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605186, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 16wk", "exp_Mcount": 6219.43}], "stomach 18wk": [{"id": "metadata_9606_SAMN03267771", "gene": 3458, "sample_id": "SAMN03267771", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605185, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 18wk", "exp_Mcount": 5820.42}], "stomach 20wk": [{"id": "metadata_9606_SAMN03267765", "gene": 3458, "sample_id": "SAMN03267765", "full_rpkm": 0.0248233, "exp_rpkm": 0.0248, "exp_total": 135, "project_desc": "PRJNA270632", "_version_": 1785734387342508032, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4494.58}, {"id": "metadata_9606_SAMN03267781", "gene": 3458, "sample_id": "SAMN03267781", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387343556608, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4566.24}, {"id": "metadata_9606_SAMN03267783", "gene": 3458, "sample_id": "SAMN03267783", "full_rpkm": 0.0, "exp_rpkm": 0.0, "exp_total": 0, "project_desc": "PRJNA270632", "_version_": 1785734387344605184, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4804.58}]}
window.taxId = 9606
</script>
<div>
<select name="p" id="project-selector">
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
<div id="gene-expr-details" class="expression-chart"></div>
</div>
</div>
</div>
<script type="text/javascript" src="https://www.gstatic.com/charts/loader.js"></script>
<script type="text/javascript">
google.charts.load('current', {
'packages':[ 'corechart']
});
</script>
</div>
</div>
</div>
<div class="rprt-section gene-bibliography">
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<div class="generif-pubmed">
<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
</h3>
<div class="generefbl-link">
<ol class="generef-link">
<li>
<a href="/pubmed/21477169/" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=21477169">Association of the interferon-γ gene (CA)n repeat polymorphism with endometriosis.</a>
<span class="pubmed-auth-date"> Kim JJ, <em>et al</em>. BJOG, 2011 Aug. PMID 21477169</span>
</li>
<li>
<a href="/pubmed/17981204/" ref="ordinalpos=2&amp;ncbi_uid=3458&amp;link_uid=17981204">Regulation of interferon-gamma during innate and adaptive immune responses.</a>
<span class="pubmed-auth-date"> Schoenborn JR, <em>et al</em>. Adv Immunol, 2007. PMID 17981204</span>
</li>
<li>
<a href="/pubmed/24671824/" ref="ordinalpos=3&amp;ncbi_uid=3458&amp;link_uid=24671824">Lack of association between interferon gamma +874 T/A polymorphism and cancer risk: an updated meta-analysis.</a>
<span class="pubmed-auth-date"> Ge YZ, <em>et al</em>. Tumour Biol, 2014 Jul. PMID 24671824</span>
</li>
<li>
<a href="/pubmed/21505270/" ref="ordinalpos=4&amp;ncbi_uid=3458&amp;link_uid=21505270">Enhanced demethylation of interferon-γ gene promoter in peripheral blood mononuclear cells is associated with acute-on-chronic hepatitis B liver failure.</a>
<span class="pubmed-auth-date"> Fan XP, <em>et al</em>. Tohoku J Exp Med, 2011 May. PMID 21505270</span>
</li>
<li>
<a href="/pubmed/18051824/" ref="ordinalpos=5&amp;ncbi_uid=3458&amp;link_uid=18051824">[Interferon gamma (IFN-gamma) level in broncholaveolar lavage (BAL) fluid is positively correlated with CD4/CD8 ratio in selected interstitial lung diseases].</a>
<span class="pubmed-auth-date"> Kopiński P, <em>et al</em>. Pol Merkur Lekarski, 2007 Jul. PMID 18051824</span>
</li>
</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=3458" title="See all 2151 citations in Pubmed">See all (2151) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
<div class="generefbl-link">
<ol class="generef-link">
<li class="gene-rif-popper">
<a href="/pubmed/39312196" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=39312196">IFN-gamma induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.</a>
<div id="gene-popper1" class="gene-rif-popper">Title: IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/39260304" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=39260304">Interleukin-37 exacerbates liver inflammation and promotes IFN-gamma production in NK cells.</a>
<div id="gene-popper2" class="gene-rif-popper">Title: Interleukin-37 exacerbates liver inflammation and promotes IFN-γ production in NK cells.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/39366761" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=39366761">Cholesterol promotes IFNG mRNA expression in CD4[+] effector/memory cells by SGK1 activation.</a>
<div id="gene-popper3" class="gene-rif-popper">Title: Cholesterol promotes IFNG mRNA expression in CD4(+) effector/memory cells by SGK1 activation.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38290045" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=38290045">IL-17 and IFN-gamma-producing Respiratory Tissue-Resident Memory CD4 T Cells Persist for Decades in Adults Immunized as Children With Whole-Cell Pertussis Vaccines.</a>
<div id="gene-popper4" class="gene-rif-popper">Title: IL-17 and IFN-γ-producing Respiratory Tissue-Resident Memory CD4 T Cells Persist for Decades in Adults Immunized as Children With Whole-Cell Pertussis Vaccines.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/39277179" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=39277179">Recurrent ocular toxoplasmosis is associated with interferon-gamma deficiency possibly due to genetic origin.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: Recurrent ocular toxoplasmosis is associated with interferon-gamma deficiency possibly due to genetic origin.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38816360" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=38816360">FLI1 promotes IFN-gamma-induced kynurenine production to impair anti-tumor immunity.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/39192947" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=39192947">The effect of infection with Toxoplasma gondii in inducing interferon-gamma in breast cancer patients.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: The effect of infection with Toxoplasma gondii in inducing interferon-gamma in breast cancer patients.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/39018367" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=39018367">Comparative single-cell analysis reveals IFN-gamma as a driver of respiratory sequelae after acute COVID-19.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae after acute COVID-19.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38838223" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=38838223">Interferon-gamma induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38869352" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=38869352">AIM2 inflammasome regulated by the IFN-gamma/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: AIM2 inflammasome regulated by the IFN-γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=3458&amp;sym=IFNG&amp;name=interferon gamma&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=3458&amp;symbol=IFNG;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=3458" class="seeall-generif">See all GeneRIFs (1669)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=IFNG[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=3458">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="associatedconditions">Associated conditions</h3>
<table class="jig-ncbigrid gtr-associated-cond">
<thead>
<tr>
<th class="description">Description</th>
<th>Tests</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<a href="/gtr/conditions/C0002874" ref="ncbi_uid=3458&amp;link_uid=C0002874">Aplastic anemia</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0002874" ref="ncbi_uid=3458&amp;link_uid=C0002874">C0002874</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/609135" ref="ncbi_uid=3458"> 609135</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C0002874[DISCUI]&amp;condition=C0002874&amp;compare_labs=1" ref="ncbi_uid=3458">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C1835407" ref="ncbi_uid=3458&amp;link_uid=C1835407">Hepatitis C virus, susceptibility to</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1835407" ref="ncbi_uid=3458&amp;link_uid=C1835407">C1835407</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/609532" ref="ncbi_uid=3458"> 609532</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C1835407[DISCUI]&amp;condition=C1835407&amp;compare_labs=1" ref="ncbi_uid=3458">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C5436498" ref="ncbi_uid=3458&amp;link_uid=C5436498">Immunodeficiency 69</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C5436498" ref="ncbi_uid=3458&amp;link_uid=C5436498">C5436498</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/618963" ref="ncbi_uid=3458"> 618963</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<span class="gtr-na">not available</span>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C1834752" ref="ncbi_uid=3458&amp;link_uid=C1834752">Mycobacterium tuberculosis, susceptibility to</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1834752" ref="ncbi_uid=3458&amp;link_uid=C1834752">C1834752</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/607948" ref="ncbi_uid=3458"> 607948</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C1834752[DISCUI]&amp;condition=C1834752&amp;compare_labs=1" ref="ncbi_uid=3458">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C1836230" ref="ncbi_uid=3458&amp;link_uid=C1836230">Susceptibility to HIV infection</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1836230" ref="ncbi_uid=3458&amp;link_uid=C1836230">C1836230</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/609423" ref="ncbi_uid=3458"> 609423</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C1836230[DISCUI]&amp;condition=C1836230&amp;compare_labs=1" ref="ncbi_uid=3458">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C1860707" ref="ncbi_uid=3458&amp;link_uid=C1860707">Tuberous sclerosis 2</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1860707" ref="ncbi_uid=3458&amp;link_uid=C1860707">C1860707</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/613254" ref="ncbi_uid=3458"> 613254</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1220" ref="ncbi_uid=3458">Tuberous Sclerosis Complex</a></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C1860707[DISCUI]&amp;condition=C1860707&amp;compare_labs=1" ref="ncbi_uid=3458">Compare labs</a>
</td>
</tr>
</tbody>
</table>
</div>
<div>
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
<thead>
<tr>
<th class="description">Description</th>
</tr>
</thead>
<tbody>
<tr>
<td>Genome-wide association identifies multiple ulcerative colitis susceptibility loci.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/20228799">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/20228799">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/23128233">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/23128233">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/21297633">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/21297633">PubMed</a></span></div></div></div></td>
</tr>
<tr>
<td>Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/19122664">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/19122664">PubMed</a></span></div></div></div></td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=IFNG[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=3458" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=3458[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=3458[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-HIV-1-interactions">
<section class="rprt-section-header" id="HIV-1-interactions">
<h2 id="header-HIV-1-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div class="fgrid">
<h3 id="replicationinteractions">Replication interactions</h3>
<table summary="replication interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivinter">HIV/tuberculosis coinfection upregulates IFNG expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25924204" href="/pubmed/25924204">PubMed</a>
</td>
</tr>
</tbody>
</table>
<h3 id="proteininteractions">Protein interactions</h3>
<table summary="protein interactions" class="jig-ncbigrid">
<thead>
<tr>
<th id="hivprotein">Protein</th>
<th id="gene-hivprotein">Gene</th>
<th id="hivinter">Interaction</th>
<th id="hivpub">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="hivprotein">
<a href="/protein/636665534">Asp</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/19424028">asp</a>
</td>
<td headers="hivinter">A pool of ASP-overlapping peptides enhance IFN-gamma responses of T cells in HIV-1 seropositive patients</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25809376" href="/pubmed/25809376">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/19424028">asp</a>
</td>
<td headers="hivinter">Antisense reading frame-derived cryptic epitopes from the env gene induce upregulation of IFNG immune-response on the surface of CD8+ T-cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25701112,25589651" href="/pubmed/25701112,25589651">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta</td>
<td headers="hivpub">
<a title="PubMed Id(s): 16160188,15481145,12089333,9658081,9225992,9108403,8764000,7815507,7511078" href="/pubmed/16160188,15481145,12089333,9658081,9225992,9108403,8764000,7815507,7511078">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Treatment of cells with HIV-1 gp120 induces the release of IFN gamma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25878112,25122197,24920818,22899554,18670216,17765942,17180012,15936090,12089333,8537091,8345204,7904170,7526537,7511078" href="/pubmed/25878112,25122197,24920818,22899554,18670216,17765942,17180012,15936090,12089333,8537091,8345204,7904170,7526537,7511078">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 Env gp120 peptides can stimulate cytoplasmic IFN-gamma response in CD8+ T cells in the presence of dendritic cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24942586" href="/pubmed/24942586">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120-induced IL-23 upregulated SOCS1 protein in T cells, which inhibits IFN-gamma production and killing of CEF-pulsed monocytes</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25234720" href="/pubmed/25234720">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120-treated myeloid dendritic cell (mDC) downregulates IL-2 and IFN-gamma production compared to LPS-treated mDC</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25234720" href="/pubmed/25234720">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Frequent IFN-gamma and TNF-alpha NK cell responses to HIV-1 gp120 are dominant during chronic HIV-1 infection</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25320293,22496218" href="/pubmed/25320293,22496218">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120-expanded CD33+ myeloid derived suppressor cells inhibits IFN-gamma release from autologous T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 23999600" href="/pubmed/23999600">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">IL-11 inhibits HIV-1 gp120-mediated downregulation of IFN-gamma in human NK cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22727646" href="/pubmed/22727646">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22496218" href="/pubmed/22496218">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) involves the p38 MAPK signaling pathway</td>
<td headers="hivpub">
<a title="PubMed Id(s): 17613714" href="/pubmed/17613714">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Peptides of gp120 representing binding regions for CD4 and chemokine receptors, as well as CD4 antibody, inhibit gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 17613714" href="/pubmed/17613714">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120 in the presence of IFN-gamma induces cytotoxicity of human brain micro vascular endothelial cells (HBMECs) derived from children but not from adults</td>
<td headers="hivpub">
<a title="PubMed Id(s): 17613714" href="/pubmed/17613714">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120</td>
<td headers="hivpub">
<a title="PubMed Id(s): 18414664" href="/pubmed/18414664">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">In the presence of HIV-1 gp120, stimulation through the CD28 pathway partially restores IL-2 and IFN-gamma production by T cell lines in response to anti-CD3 antibodies</td>
<td headers="hivpub">
<a title="PubMed Id(s): 18670216,8706326" href="/pubmed/18670216,8706326">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp120 inhibits natural killer (NK) cell natural cytotoxicity and this inhibition also affects the production of the proinflammatory cytokine interferon-gamma (IFN-gamma); the inhibitory activity of gp120 can be prevented by coincubation with VIP</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22727646,15936090,10933622" href="/pubmed/22727646,15936090,10933622">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Induction of the receptor activator of cytokine nuclear factor kappa B ligand (RANKL) is mediated by HIV-1 gp120; the gp120-mediated induction of RANKL is blocked by interferon-gamma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 15936090,15320903,12975380" href="/pubmed/15936090,15320903,12975380">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Secretion of IL-12 is found in macrophages primed with gamma interferon (IFN-gamma) and subsequently treated with gp120</td>
<td headers="hivpub">
<a title="PubMed Id(s): 8648753" href="/pubmed/8648753">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Secretion of IL-2 and IFN-gamma stimulated with anti-CD3 antibodies is inhibited by HIV-1 gp120 in T cell lines</td>
<td headers="hivpub">
<a title="PubMed Id(s): 8706326" href="/pubmed/8706326">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 8661419" href="/pubmed/8661419">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2</td>
<td headers="hivpub">
<a title="PubMed Id(s): 9534962,7583919,1905933" href="/pubmed/9534962,7583919,1905933">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">IFN-gamma and gp120-induced activation of Na+/H+ exchange appears to be mediated through activation of tyrosine kinase (TK), because TK inhibitors block the action of IFN-gamma and gp120</td>
<td headers="hivpub">
<a title="PubMed Id(s): 8188658" href="/pubmed/8188658">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Treatment of human colonic epithelial cells with recombinant gamma-interferon (rlFN gamma) induces a dose-dependent inhibition of Galactosyl ceramide (GalCer) expression on the cell surface; GalCer is a receptor for HIV-1 gp120</td>
<td headers="hivpub">
<a title="PubMed Id(s): 7941321" href="/pubmed/7941321">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629363">Envelope surface glycoprotein gp160, precursor</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">HIV-1 Env induces release of IFN-gamma from CAR-transduced T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25878112" href="/pubmed/25878112">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">Pretreatment of CD4+ cells with HIV-1 gp160 significantly reduces PHA-induced secretion of IFN-gamma and IL-2 but augments IL-4 production</td>
<td headers="hivpub">
<a title="PubMed Id(s): 9712080,7523014" href="/pubmed/9712080,7523014">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/19172954">Envelope transmembrane glycoprotein gp41</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IFN-gamma in peptide-treated PBMCs</td>
<td headers="hivpub">
<a title="PubMed Id(s): 23383108" href="/pubmed/23383108">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">PWM, LPS, IFN-gamma and IL-6 can increase HIV-1 gp41 binding to human B cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 8247028" href="/pubmed/8247028">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155971">env</a>
</td>
<td headers="hivinter">IFN-gamma production in mononuclear leukocytes from an HIV-1-seropositive man is induced by different concentrations of a recombinant HIV-1 envelope glycoprotein gp41 and gp120 fragment</td>
<td headers="hivpub">
<a title="PubMed Id(s): 2452186" href="/pubmed/2452186">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872818">Nef</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">HIV-1 Nef-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24899193" href="/pubmed/24899193">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">The proportion of HIV-1 Nef-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24227857" href="/pubmed/24227857">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">Coincubation of HIV-1 Nef and IFN-gamma downregulates COX-2 expression compared to untreated, Nef- or IFN-gamma-treated Caco-2 cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 21858117" href="/pubmed/21858117">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3alpha production by Caco-2 cells while downregulating IL-10 production</td>
<td headers="hivpub">
<a title="PubMed Id(s): 21858117" href="/pubmed/21858117">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">Exogenous Nef taken up by Caco-2 cells increases intestinal epithelial permeability, inhibits the IFN-gamma-induced reduction of transepitelial resistance and decreases the tight junction proteins occludin and ZO1 expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 21858117" href="/pubmed/21858117">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">HIV-1 Nef has super antigen properties in that it binds to MHC class II antigens and activates T cells, causing T cell proliferation and production of the T helper 1 cytokines IL-2 and IFN-gamma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 20535218,18539368,8769094,8102828" href="/pubmed/20535218,18539368,8769094,8102828">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">Upon T cell activation, HIV-1 Nef expression downregulates both IL-2 and IFN-gamma production in a dose-dependent manner</td>
<td headers="hivpub">
<a title="PubMed Id(s): 15638726,8765022,8598486" href="/pubmed/15638726,8765022,8598486">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/156110">nef</a>
</td>
<td headers="hivinter">PBMC proliferation induced by exogenous HIV-1 Nef is associated with upregulation of interferon-gamma (IFN-gamma)</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22395607,17600593,10388525" href="/pubmed/22395607,17600593,10388525">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629360">Pr55(Gag)</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Treatment of PBMCs taken from treatment-naive HIV chronically infected individuals with a HIV-1 Gag peptide pool in the presence of ADAM10 inhibitor upregulates the levels of Tim-3 and IFN-gamma in CD8+ T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25609823" href="/pubmed/25609823">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1-exposed monocyte-derived dendritic cells induce weak secretion of IFN-gamma and low amounts of intracellular Gag expression in the presence of SAMHD1</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25926647" href="/pubmed/25926647">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 Gag peptides can stimulate cytoplasmic IFN-gamma response in CD8 T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25609823,24942586,22395607,17002607,16263796" href="/pubmed/25609823,24942586,22395607,17002607,16263796">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25240755" href="/pubmed/25240755">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">The proportion of HIV-1 Gag-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24227857" href="/pubmed/24227857">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFN-gamma-stimulated expression of APOL1 in differentiated U937 monocytes contributes to inhibition of HIV-1 Gag/p24 expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24173214" href="/pubmed/24173214">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Gag-specific interferon (IFN)-gamma secreting responses correlate with the rate of disease progression as defined by the annual rate of CD4 decline in patients</td>
<td headers="hivpub">
<a title="PubMed Id(s): 22948269,18525269" href="/pubmed/22948269,18525269">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release IFN-gamma in a dose and time dependent manner</td>
<td headers="hivpub">
<a title="PubMed Id(s): 18945465" href="/pubmed/18945465">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 Gag virus-like particle-induced human monocyte-derived dendritic cell maturation activates autologous NK cells, leading to their proliferation, and production of interferon-gamma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 21778700" href="/pubmed/21778700">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 Gag p24-specific CD4+ T cells producing IL-2 and IFN-gamma are increased post vaccination</td>
<td headers="hivpub">
<a title="PubMed Id(s): 17013989" href="/pubmed/17013989">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Interferon-gamma can counteract the inhibitory effect of peptides based on the Capsid protein of HIV-1 Gag on antibody response to Sheep Red Cell Antigen</td>
<td headers="hivpub">
<a title="PubMed Id(s): 9743208,8809126" href="/pubmed/9743208,8809126">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">The Capsid (p24) protein of HIV-1 Gag inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1</td>
<td headers="hivpub">
<a title="PubMed Id(s): 1905983" href="/pubmed/1905983">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">The Matrix protein of HIV-1 Gag enhances the cytokine-induced production of interferon gamma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 12542496,12105273" href="/pubmed/12542496,12105273">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">The Matrix protein of HIV-1 Gag and interferon gamma are structurally similar and have been found to bind in vitro</td>
<td headers="hivpub">
<a title="PubMed Id(s): 8679287,8619916,8065455,2514776" href="/pubmed/8679287,8619916,8065455,2514776">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629358">Tat</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat upregulates the production of cytokines, including TNF-alpha, IL-6, IL-10, IL-12, IFN-alpha1, and IFN-gamma, in human monocyte derived-dendritic cells and in primary human Muller glia</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25943894,24073214" href="/pubmed/25943894,24073214">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25313583" href="/pubmed/25313583">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">The contact between peptide-stimulated CD8+ T-lymphocytes and immobilized HIV-1 Tat inhibits the release of IFN-gamma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25313583" href="/pubmed/25313583">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat upregulates IL-2 and IFN-gamma production in stimulated CD8+ T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24841128" href="/pubmed/24841128">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">JAK/STAT pathway plays a major role in Tat/IFN-gamma-mediated CXCL10 induction in macrophages</td>
<td headers="hivpub">
<a title="PubMed Id(s): 20588103,18569454" href="/pubmed/20588103,18569454">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes</td>
<td headers="hivpub">
<a title="PubMed Id(s): 23376103" href="/pubmed/23376103">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24073214" href="/pubmed/24073214">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor</td>
<td headers="hivpub">
<a title="PubMed Id(s): 23376103,18569454" href="/pubmed/23376103,18569454">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase</td>
<td headers="hivpub">
<a title="PubMed Id(s): 23376103,19941336" href="/pubmed/23376103,19941336">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation</td>
<td headers="hivpub">
<a title="PubMed Id(s): 21099673" href="/pubmed/21099673">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">Pretreatment of THP-1 cells with HIV-1 Tat/T-bet co-cultures with CD4+T cells, resulting in increased levels of IFN-gamma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 18300036" href="/pubmed/18300036">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat impairs the IFNgamma-receptor signaling pathway, in primary human monocytes, at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity</td>
<td headers="hivpub">
<a title="PubMed Id(s): 21099673,20588103,19279332" href="/pubmed/21099673,20588103,19279332">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha</td>
<td headers="hivpub">
<a title="PubMed Id(s): 20588103,19479051" href="/pubmed/20588103,19479051">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat acts as a co-stimulatory molecule that affects viral replication by modulating host immune response through induction of T-bet expression and IFN-gamma secretion</td>
<td headers="hivpub">
<a title="PubMed Id(s): 21085635,16375755,15737643" href="/pubmed/21085635,16375755,15737643">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat interacts with IFN-gamma, which upregulates the Tat receptor VEGFR2/KDR, to produce cytotoxicity in human brain micro vascular endothelial cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 14602571" href="/pubmed/14602571">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat upregulates IFN-gamma expression by uninfected mononuclear cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 20588103,18539368,7818827" href="/pubmed/20588103,18539368,7818827">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat inhibits IFN-gamma release by NK cells upon contact with dendritic cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 11751951" href="/pubmed/11751951">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat delivered by CyaA from Bordetella pertussis induces a Th1-polarized immune response and HIV-Tat-specific gamma interferon-producing CD8(+) T cells are generated after vaccination with CyaA-E5-Tat in a CD4(+) T-cell-independent manner</td>
<td headers="hivpub">
<a title="PubMed Id(s): 16014948" href="/pubmed/16014948">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat synergizes with IFN-gamma to induce iNOS activity in purified rat microglial cultures</td>
<td headers="hivpub">
<a title="PubMed Id(s): 10446807" href="/pubmed/10446807">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS</td>
<td headers="hivpub">
<a title="PubMed Id(s): 9916748" href="/pubmed/9916748">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">IFN-gamma inhibits the transactivation of the HIV-1 LTR promoter by HIV-1 Tat</td>
<td headers="hivpub">
<a title="PubMed Id(s): 1400376" href="/pubmed/1400376">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat inhibits IFN-gamma induced iNOS activity in a murine macrophage cell line</td>
<td headers="hivpub">
<a title="PubMed Id(s): 8760410" href="/pubmed/8760410">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">IL-1beta, TNF-alpha, and IFN-gamma synergize with HIV-1 Tat to promote in nude mice the development of angioproliferative Kaposi's sarcoma-like lesions</td>
<td headers="hivpub">
<a title="PubMed Id(s): 16375755,10438928" href="/pubmed/16375755,10438928">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155871">tat</a>
</td>
<td headers="hivinter">HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication</td>
<td headers="hivpub">
<a title="PubMed Id(s): 1708818" href="/pubmed/1708818">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/9629361">Vif</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155459">vif</a>
</td>
<td headers="hivinter">HIV-1 Vif downregulates the expression of interferon-gamma (IFNG) in Vif-expression T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 23333304" href="/pubmed/23333304">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28872817">Vpr</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">Exogenous Vpr compromises subsequent pDC/NK interplay through inhibition of IFN-gamma production by NK cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 19559726" href="/pubmed/19559726">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">HIV-1 Vpr inhibits interferon gamma secretion in infected T cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 18417583,17023015" href="/pubmed/18417583,17023015">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway</td>
<td headers="hivpub">
<a title="PubMed Id(s): 18417583" href="/pubmed/18417583">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155807">vpr</a>
</td>
<td headers="hivinter">Expression of HIV-1 Vpr in U937 cells upregulates gamma interferon expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 10775602" href="/pubmed/10775602">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/19172948">capsid</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Peptides derived from HIV-1 p24 induces release of IFN-gamma in monocyte-derived DCs and macrophages</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25781895" href="/pubmed/25781895">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">PLA-p24- or p24-loaded human monocyte-derived dendritic cells enhance HIV-1-specific T-cell response by increased levels of IFN-gamma and IL-2 in comparison with PLA-loaded cells alone</td>
<td headers="hivpub">
<a title="PubMed Id(s): 25240755" href="/pubmed/25240755">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 CA-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24899193" href="/pubmed/24899193">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFN-gamma-stimulated expression of APOL1 in differentiated U937 monocytes contributes to inhibition of HIV-1 Gag/p24 expression</td>
<td headers="hivpub">
<a title="PubMed Id(s): 24173214" href="/pubmed/24173214">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">IFN-gamma and/or IL-2 responses characterized by secreting cells contribute more to the HIV-1 CA specific response in acute infection early disease (AIED) than in chronically infected individuals</td>
<td headers="hivpub">
<a title="PubMed Id(s): 19135418" href="/pubmed/19135418">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Pretreating dendritic cells with INF-gamma overcomes the HIV-1 CA-mediated decreased levels of presentation of ovalbumin to a SIINFEKL-specific CD8(+) T-cell hybridoma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 19403671" href="/pubmed/19403671">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1</td>
<td headers="hivpub">
<a title="PubMed Id(s): 1905983" href="/pubmed/1905983">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to Sheep Red Cell Antigen</td>
<td headers="hivpub">
<a title="PubMed Id(s): 9743208,8809126" href="/pubmed/9743208,8809126">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/28876542">matrix</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 Matrix enhances the cytokine-induced production of interferon gamma</td>
<td headers="hivpub">
<a title="PubMed Id(s): 16427155,12542496,12105273" href="/pubmed/16427155,12542496,12105273">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein"></td>
<td headers="gene-hivprotein">
<a href="/gene/155030">gag</a>
</td>
<td headers="hivinter">HIV-1 Matrix and interferon gamma are structurally similar and have been found to bind in vitro</td>
<td headers="hivpub">
<a title="PubMed Id(s): 8679287,8619916,8065455,2514776" href="/pubmed/8679287,8619916,8065455,2514776">PubMed</a>
</td>
</tr>
<tr>
<td headers="hivprotein">
<a href="/protein/25121907">reverse transcriptase</a>
</td>
<td headers="gene-hivprotein">
<a href="/gene/155348">gag-pol</a>
</td>
<td headers="hivinter">Up-regulation of LMP7 by IFN-gamma enhances proteasomal degradation of HIV-1 RT and presentation of the VIYQYMDDL epitope derived from HIV-1 RT</td>
<td headers="hivpub">
<a title="PubMed Id(s): 10358150" href="/pubmed/10358150">PubMed</a>
</td>
</tr>
</tbody>
</table>
<p class="withnote">
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
</p>
</div>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/3458#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/3458/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">PMC22712P3 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=272150%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=272150">UniSTS:272150</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">IFNG (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=266297%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=266297">UniSTS:266297</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">NoName (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=482383%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=482383">UniSTS:482383</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">IFNG (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=480107%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=480107">UniSTS:480107</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">GDB:624768 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=158355%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=158355">UniSTS:158355</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">GDB:624777 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=158356%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=158356">UniSTS:158356</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">PMC135596P1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=270757%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=270757">UniSTS:270757</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">GDB:181602 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=155309%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=155309">UniSTS:155309</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">PMC154023P1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=271283%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=271283">UniSTS:271283</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">GDB:207646 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=156120%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=156120">UniSTS:156120</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">PMC199428P1 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=271866%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=271866">UniSTS:271866</a></li></ul></li>
</ul>
</div>
</div>
<div></div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/3458/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005125">enables cytokine activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005125">enables cytokine activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-2-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/16914093" target="_blank" title="PubMed ID 16914093" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16914093">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005125">enables cytokine activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-3-0" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/26227742" target="_blank" title="PubMed ID 26227742" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=26227742">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-4-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/7617032,11250200,18252829,28514442,33961781" target="_blank" title="PubMed ID 7617032,11250200,18252829,28514442,33961781" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=7617032,11250200,18252829,28514442,33961781">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005133">enables type II interferon receptor binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-5-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0038096">involved_in Fc-gamma receptor signaling pathway involved in phagocytosis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/7544003" target="_blank" title="PubMed ID 7544003" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=7544003">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0002250">involved_in adaptive immune response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006915">acts_upstream_of_or_within apoptotic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/7828849" target="_blank" title="PubMed ID 7828849" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=7828849">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048143">involved_in astrocyte activation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18375019" target="_blank" title="PubMed ID 18375019" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=18375019">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048143">involved_in astrocyte activation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-5-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007166">involved_in cell surface receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-6-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10477596" target="_blank" title="PubMed ID 10477596" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=10477596">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007259">involved_in cell surface receptor signaling pathway via JAK-STAT</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0097696">involved_in cell surface receptor signaling pathway via STAT</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15604419" target="_blank" title="PubMed ID 15604419" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=15604419">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098586">involved_in cellular response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
<div id="evidence-code-9-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/14525967,15864272" target="_blank" title="PubMed ID 14525967,15864272" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=14525967,15864272">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051607">involved_in defense response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0097191">involved_in extrinsic apoptotic signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-11-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16942485" target="_blank" title="PubMed ID 16942485" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16942485">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006959">involved_in humoral immune response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-12-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0002281">involved_in macrophage activation involved in immune response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-13-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/30634164" target="_blank" title="PubMed ID 30634164" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=30634164">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030225">involved_in macrophage differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-14-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/30634164" target="_blank" title="PubMed ID 30634164" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=30634164">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001774">involved_in microglial cell activation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-15-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/7715705,19808651" target="_blank" title="PubMed ID 7715705,19808651" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=7715705,19808651">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001774">involved_in microglial cell activation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-16-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045892">involved_in negative regulation of DNA-templated transcription</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-17-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23629966" target="_blank" title="PubMed ID 23629966" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=23629966">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1900222">involved_in negative regulation of amyloid-beta clearance</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-18-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030857">involved_in negative regulation of epithelial cell differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-19-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010629">involved_in negative regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-20-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23817958" target="_blank" title="PubMed ID 23817958" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=23817958">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010629">involved_in negative regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-21-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032700">involved_in negative regulation of interleukin-17 production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-22-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18501882" target="_blank" title="PubMed ID 18501882" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=18501882">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048662">involved_in negative regulation of smooth muscle cell proliferation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-23-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-23-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16942485" target="_blank" title="PubMed ID 16942485" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16942485">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000122">involved_in negative regulation of transcription by RNA polymerase II</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-24-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-24-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0150076">involved_in neuroinflammatory response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-25-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-25-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032834">involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-26-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-26-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20209097" target="_blank" title="PubMed ID 20209097" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=20209097">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045348">involved_in positive regulation of MHC class II biosynthetic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-27-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-27-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1904783">involved_in positive regulation of NMDA glutamate receptor activity</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-28-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-28-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1902004">involved_in positive regulation of amyloid-beta formation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-29-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-29-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19808651" target="_blank" title="PubMed ID 19808651" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=19808651">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1902004">involved_in positive regulation of amyloid-beta formation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-30-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-30-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010508">involved_in positive regulation of autophagy</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-31-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-31-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23629966,26347139" target="_blank" title="PubMed ID 23629966,26347139" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=23629966,26347139">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060559">involved_in positive regulation of calcidiol 1-monooxygenase activity</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-32-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-32-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9282826" target="_blank" title="PubMed ID 9282826" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=9282826">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008284">involved_in positive regulation of cell population proliferation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-33-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-33-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1901857">involved_in positive regulation of cellular respiration</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-34-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-34-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032722">involved_in positive regulation of chemokine production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-35-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-35-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19423618" target="_blank" title="PubMed ID 19423618" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=19423618">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1904798">involved_in positive regulation of core promoter binding</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-36-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-36-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23629966" target="_blank" title="PubMed ID 23629966" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=23629966">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001819">involved_in positive regulation of cytokine production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-37-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-37-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/30634164" target="_blank" title="PubMed ID 30634164" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=30634164">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010634">involved_in positive regulation of epithelial cell migration</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-38-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-38-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11698262" target="_blank" title="PubMed ID 11698262" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=11698262">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1903543">involved_in positive regulation of exosomal secretion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-39-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-39-1" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11487543" target="_blank" title="PubMed ID 11487543" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=11487543">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060550">involved_in positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-40-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-40-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9282826" target="_blank" title="PubMed ID 9282826" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=9282826">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060552">involved_in positive regulation of fructose 1,6-bisphosphate metabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-41-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-41-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9282826" target="_blank" title="PubMed ID 9282826" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=9282826">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">involved_in positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-42-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-42-1" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11487543" target="_blank" title="PubMed ID 11487543" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=11487543">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">acts_upstream_of_or_within positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-43-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-43-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20164187" target="_blank" title="PubMed ID 20164187" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=20164187">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">involved_in positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-44-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-44-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19423618,20209097,22504299,23817958" target="_blank" title="PubMed ID 19423618,20209097,22504299,23817958" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=19423618,20209097,22504299,23817958">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">involved_in positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-45-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-45-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19808651" target="_blank" title="PubMed ID 19808651" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=19808651">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">involved_in positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-46-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-46-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20889566" target="_blank" title="PubMed ID 20889566" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=20889566">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">involved_in positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-47-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-47-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045821">involved_in positive regulation of glycolytic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-48-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-48-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050729">involved_in positive regulation of inflammatory response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-49-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-49-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/30634164" target="_blank" title="PubMed ID 30634164" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=30634164">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032731">involved_in positive regulation of interleukin-1 beta production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-50-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-50-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032735">involved_in positive regulation of interleukin-12 production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-51-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-51-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/7605994,8557999" target="_blank" title="PubMed ID 7605994,8557999" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=7605994,8557999">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032747">involved_in positive regulation of interleukin-23 production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-52-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-52-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20027291" target="_blank" title="PubMed ID 20027291" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=20027291">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032755">involved_in positive regulation of interleukin-6 production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-53-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-53-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/30634164" target="_blank" title="PubMed ID 30634164" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=30634164">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1904440">involved_in positive regulation of iron ion import across plasma membrane</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-54-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-54-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051044">involved_in positive regulation of membrane protein ectodomain proteolysis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-55-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-55-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18373975" target="_blank" title="PubMed ID 18373975" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=18373975">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050769">involved_in positive regulation of neurogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-56-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-56-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19808651" target="_blank" title="PubMed ID 19808651" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=19808651">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045429">involved_in positive regulation of nitric oxide biosynthetic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-57-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-57-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8383325" target="_blank" title="PubMed ID 8383325" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=8383325">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045672">involved_in positive regulation of osteoclast differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-58-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-58-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16220542" target="_blank" title="PubMed ID 16220542" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16220542">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0033141">acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation of STAT protein</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-59-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-59-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16280321" target="_blank" title="PubMed ID 16280321" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16280321">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050766">involved_in positive regulation of phagocytosis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-60-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-60-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0090312">involved_in positive regulation of protein deacetylation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-61-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-61-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23629966" target="_blank" title="PubMed ID 23629966" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=23629966">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042307">involved_in positive regulation of protein import into nucleus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-62-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-62-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22504299" target="_blank" title="PubMed ID 22504299" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=22504299">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1903078">involved_in positive regulation of protein localization to plasma membrane</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-63-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
<div id="evidence-code-63-1" class="ecode">
<br />
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
</div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11487543" target="_blank" title="PubMed ID 11487543" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=11487543">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0071902">involved_in positive regulation of protein serine/threonine kinase activity</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-64-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-64-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22504299" target="_blank" title="PubMed ID 22504299" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=22504299">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031334">involved_in positive regulation of protein-containing complex assembly</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-65-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-65-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/22504299" target="_blank" title="PubMed ID 22504299" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=22504299">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034393">involved_in positive regulation of smooth muscle cell apoptotic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-66-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-66-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16942485" target="_blank" title="PubMed ID 16942485" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16942485">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045944">involved_in positive regulation of transcription by RNA polymerase II</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-67-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-67-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:2000309">involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-68-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-68-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16220542" target="_blank" title="PubMed ID 16220542" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16220542">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032760">involved_in positive regulation of tumor necrosis factor production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-69-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-69-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/7715705" target="_blank" title="PubMed ID 7715705" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=7715705">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042531">acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-70-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-70-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16280321" target="_blank" title="PubMed ID 16280321" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16280321">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060557">involved_in positive regulation of vitamin D biosynthetic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-71-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-71-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9282826" target="_blank" title="PubMed ID 9282826" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=9282826">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050796">involved_in regulation of insulin secretion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-72-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-72-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8383325" target="_blank" title="PubMed ID 8383325" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=8383325">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0019222">involved_in regulation of metabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-73-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-73-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/7715705" target="_blank" title="PubMed ID 7715705" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=7715705">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0009615">acts_upstream_of_or_within response to virus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-74-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-74-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16280321" target="_blank" title="PubMed ID 16280321" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16280321">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060333">involved_in type II interferon-mediated signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-75-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-75-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16914093,22504299,23629966" target="_blank" title="PubMed ID 16914093,22504299,23629966" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16914093,22504299,23629966">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060333">involved_in type II interferon-mediated signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-76-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-76-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19808651" target="_blank" title="PubMed ID 19808651" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=19808651">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060333">involved_in type II interferon-mediated signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-77-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
<div id="evidence-code-77-1" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/14525967,15864272" target="_blank" title="PubMed ID 14525967,15864272" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=14525967,15864272">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0038196">involved_in type III interferon-mediated signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-78-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-78-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16914093" target="_blank" title="PubMed ID 16914093" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16914093">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005576">located_in extracellular region</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/20041150" target="_blank" title="PubMed ID 20041150" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=20041150">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005576">located_in extracellular region</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-2-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005615">is_active_in extracellular space</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005615">is_active_in extracellular space</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/16914093,33706478" target="_blank" title="PubMed ID 16914093,33706478" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=16914093,33706478">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>interferon gamma</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>IFN-gamma</dd>
<dd>immune interferon</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=3458&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="genomic-p89966720">Genomic </h4>
<ol>
<li>
<p>NG_015840.1 RefSeqGene</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>5002..9974</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NG_015840.1?from=5002&amp;to=9974&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NG_015840.1?from=5002&amp;to=9974&amp;report=genbank">GenBank</a>, <a href="/nuccore/NG_015840.1?from=5002&amp;to=9974&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NG_015840.1?from=5002&amp;to=9974&amp;report=fasta">FASTA</a>, <a href="/nuccore/NG_015840.1?from=4255&amp;to=10719&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NG_015840.1?from=4255&amp;to=10719&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p11968640">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_000619.3">NM_000619.3</a><a href="/protein/NP_000610.2">NP_000610.2</a>  interferon gamma precursor</p>
<p>
<a href="/ipg/NP_000610.2/" ref="ncbi_uid=3458">See identical proteins and their annotated locations for NP_000610.2</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AC007458, BC070256, V00543">AC007458, BC070256, V00543</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS8980.1">CCDS8980.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B5BU88" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=3458&amp;nlmid=&amp;db=gene">B5BU88</a>, <a href="https://www.uniprot.org/uniprot/P01579" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=3458&amp;nlmid=&amp;db=gene">P01579</a>, <a href="https://www.uniprot.org/uniprot/Q53ZV4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=3458&amp;nlmid=&amp;db=gene">Q53ZV4</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A7R8GUN6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=3458&amp;nlmid=&amp;db=gene">A0A7R8GUN6</a>, <a href="https://www.uniprot.org/uniprot/A8YQE4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=3458&amp;nlmid=&amp;db=gene">A8YQE4</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000229135.3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=3458&amp;nlmid=&amp;db=gene">ENSP00000229135.3</a>, <a href="http://www.ensembl.org/id/ENST00000229135.4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=3458&amp;nlmid=&amp;db=gene">ENST00000229135.4</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_000610.2">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395581">pfam00714</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">15</span><span class="cddto">152</span></dt>
<dd class="clearfix"> IFN-gamma; Interferon gamma</dd>
</dl>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p123525152">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p123525152">Genomic </h4>
<ol>
<li>
<p>NC_000012.12 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>68154768..68159740 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000012.12?from=68154768&amp;to=68159740&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_000012.12?from=68154768&amp;to=68159740&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_000012.12?from=68154768&amp;to=68159740&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_000012.12?from=68154768&amp;to=68159740&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_000012.12?from=68154021&amp;to=68160485&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_000012.12?from=68154021&amp;to=68160485&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p107286320">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p107286320">Genomic </h4>
<ol>
<li>
<p>NC_060936.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>68134280..68139252 complement</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060936.1?from=68134280&amp;to=68139252&amp;report=genbank&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_060936.1?from=68134280&amp;to=68139252&amp;report=genbank&amp;strand=true">GenBank</a>, <a href="/nuccore/NC_060936.1?from=68134280&amp;to=68139252&amp;report=fasta&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_060936.1?from=68134280&amp;to=68139252&amp;report=fasta&amp;strand=true">FASTA</a>, <a href="/nuccore/NC_060936.1?from=68133533&amp;to=68139997&amp;report=graph&amp;content=5&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=NC_060936.1?from=68133533&amp;to=68139997&amp;report=graph&amp;content=5&amp;strand=true">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/3458/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">P01579.1</td>
<td headers="rs-link rs-genepept">
<a href="/protein/124479" ref="ordinalpos=1&amp;ncbi_uid=3458&amp;link_uid=124479">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/P01579">UniProtKB/Swiss-Prot:P01579</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<div id="lsdb"><h3 class="withnote" id="locusspecificdatabases"><a class="jig-ncbitoggler-open">Locus-specific Databases</a></h3><div><ul class="locusdb"><li><a href="http://databases.lovd.nl/shared/genes/IFNG" ref="from_uid=3458" class="lsdblink">IFNG database</a></li></ul></div></div>
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/IFNG?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>IFNG products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000111537" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>IFNG gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/3458/" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (11 hits/1324 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
<ul>
<li>
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7642">
<span>IFNG</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=IFNG_1" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>IFNG_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/P01579" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span><span class="regis-rsc"></span>Human Gene Mutation Database</li>
<ul>
<li>
<a target="_blank" href="http://www.hgmd.cf.ac.uk/ac/gene.php?gene=IFNG" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3100">
<span>Human Gene Mutation Database</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Reproductive&amp;modeInput=Absolute&amp;primaryGene=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&amp;modeInput=Absolute&amp;primaryGene=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&amp;modeInput=Absolute&amp;primaryGene=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D3458%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=45916" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000111537" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN14114/" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Pharmacogenomics Knowledge Base</li>
<ul>
<li>
<a target="_blank" href="https://www.pharmgkb.org/gene/PA29674" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4067">
<span>Annotated Pharmacogenomic Information for IFNG [PharmGKB]</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/Interferon-gamma" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=IFNG" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for IFNG</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/ifn-gamma/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>IFN-gamma Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/ifn-gamma/elisa-kits?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=elisakits" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>IFN-gamma ELISA Kits</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/ifn-gamma/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>IFN-gamma Proteins</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/IFN-gamma-antibody.html" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/IFN-gamma-antibody.html" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&amp;field=5&amp;key=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order TALEN/CRISPR clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&amp;field=5&amp;prt=16&amp;key=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order miRNA target clones</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneTex Inc</li>
<ul>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=3458&amp;type=01&amp;page=1" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Quality Antibodies</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=3458&amp;type=03&amp;page=1" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Recombinant Proteins and Peptides</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=IFNG" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order IFNG cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=3458" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open">
<span>Miscellaneous</span>
</a>
<ul>
<li><span class="free-rsc"></span>Reactome</li>
<ul>
<li>
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:P01579" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Entity:P01579</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-74160" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Gene expression (Transcription)</span>
</a>
</li>
<li>
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-168256" ref="itool=Gene_FullReport&amp;uid=3458&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=4914">
<span>Reactome Event:Immune System</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
<div id="urls-in-genombrowser" style="display:none">
</div>
</div>
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</div>
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</div>
</div>
</div>
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<!-- sidebar close/hide button-->
<div class="ui-helper-clearfix">
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#HIV-1-interactions">HIV-1 interactions</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
<div class="subsection-links">
<a href="#lsdb">Locus-specific Databases</a>
</div>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
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<li>
<a href="#">Loading...</a>
</li>
</ul>
</div>
</div>
<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/3458" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&amp;from_uid=3458" ref="log$=recordlinks">3D structures</a>
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=3458" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=3458" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=3458" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&amp;from_uid=3458" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=3458" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=3458" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=3458" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=3458" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=3458" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=3458" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=3458" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=3458" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=3458" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=3458" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gap?LinkName=gene_gap&amp;from_uid=3458" ref="log$=recordlinks">GAP</a>
<div class="brieflinkpop offscreen_noflow">GAP Links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=3458" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=3458" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=3458" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=3458[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=3458" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&amp;from_uid=3458" ref="log$=recordlinks">MedGen</a>
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=3458" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=3458" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=3458" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=3458" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=3458" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=3458" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=3458" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=3458" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=3458" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=3458" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=3458" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=3458" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore/267844874?report=graph" ref="log$=recordlinks">RefSeqGene</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeqGenes</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&amp;from_uid=3458" ref="log$=recordlinks">Related gene-specific medical variations</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=3458" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=3458" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=3458[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5438">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000111537">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:5438">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=3458">AceView</a>
</li>
<li>
<a href="http://databases.lovd.nl/shared/genes/IFNG">IFNG database</a>
</li>
<li>
<a href="http://www.pharmgkb.org/gene/PA29674">PharmGKB</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_000619">UCSC</a>
</li>
<li>
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC070256">MGC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=IFNG&amp;geneID=3458&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:3458">KEGG</a>
</li>
<li>
<a href="https://reactome.org/content/query?q=UniProt:P01579">Reactome</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
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<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
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<a href="/books/NBK3842/">My NCBI help</a>
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<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
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<a href="/gene/statistics/">Statistics</a>
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<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
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<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
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<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
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<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
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<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
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<div class="ralinkpop offscreen_noflow">IFNG interferon gamma [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:3458</div></div>
<div class="tertiary">Gene</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9df52b15b832ebc0706ad">interferon gamma precursor [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">interferon gamma precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|56786138|ref|NP_000610.2|</div></div>
<div class="tertiary">Protein</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9df4fa68b6b5afc6bbbe2">IFNB1 interferon beta 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">IFNB1 interferon beta 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:3456</div></div>
<div class="tertiary">Gene</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9df4ea68b6b5afc6bb219">interferon beta precursor [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">interferon beta precursor [Homo sapiens]<div class="brieflinkpopdesc">gi|4504603|ref|NP_002167.1|</div></div>
<div class="tertiary">Protein</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9df4cf4a390645e342282">IFNAR1 interferon alpha and beta receptor subunit 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">IFNAR1 interferon alpha and beta receptor subunit 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:3454</div></div>
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