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3893 lines
No EOL
335 KiB
XML
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<h1 class="res_name"><a href="/gene/">Gene</a></h1>
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<h2 class="res_tagline">Genes and mapped phenotypes</h2>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="medgen">MedGen</option><option value="books">Books</option><option value="gene" selected="selected" class="last" data-ac_dict="gene">Gene</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<input name="EntrezSystem2.PEntrez.Gene.Gene_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
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<div id="faceted_search" class="facet_hide">
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<h2 class="offscreen_noflow">Result Filters</h2>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'1896',linkname:'',idsfromresult:'18810',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9ccb869195c35ad688eeb" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="1896" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<span style="display: block; text-align: center;">S</span>
|
||
<span style="display: block; text-align: center;">I</span>
|
||
<span style="display: block; text-align: center;">D</span>
|
||
<span style="display: block; text-align: center;">E</span>
|
||
<span style="display: block; text-align: center;">B</span>
|
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<span style="display: block; text-align: center;">A</span>
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<span style="display: block; text-align: center;">R</span>
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<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="1" value="full_report" format="" id="full_report" checked="true" /><label for="full_report">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="2" value="full_report" format="text" id="full_reporttext" /><label for="full_reporttext">Full Report (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="3" value="expression" format="" id="expression" /><label for="expression">Expression</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="4" value="gene_table" format="" id="gene_table" /><label for="gene_table">Gene Table</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="5" value="gene_table" format="text" id="gene_tabletext" /><label for="gene_tabletext">Gene Table (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="6" value="generif" format="" id="generif" /><label for="generif">GeneRIF</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="7" value="docsum" format="" id="docsum" /><label for="docsum">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="8" value="docsum" format="text" id="docsumtext" /><label for="docsumtext">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="9" value="tabular" format="" id="tabular" /><label for="tabular">Tabular</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="10" value="tabular" format="text" id="tabulartext" /><label for="tabulartext">Tabular (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="11" value="asn1" format="text" id="asn1text" /><label for="asn1text">ASN.1</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="12" value="xml" format="text" id="xmltext" /><label for="xmltext">XML</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="13" value="uilist" format="text" id="uilisttext" /><label for="uilisttext">UI List</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
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||
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FFormat" sid="1"><option value="full_report" format="text" selected="selected">Full Report (text)</option><option value="gene_table" format="text">Gene Table (text)</option><option value="docsum" format="text">Summary (text)</option><option value="tabular" format="text">Tabular (text)</option><option value="asn1" format="text">ASN.1</option><option value="xml" format="text">XML</option><option value="uilist" format="text">UI List</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileFormat" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Presentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="rprt full-rprt">
|
||
<div>
|
||
<div class="rprt-header">
|
||
<input type="hidden" id="gene-tax-id" value="10090" />
|
||
<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">Plec</span> plectin [ <em class="tax">Mus musculus</em> (house mouse)
|
||
]
|
||
</h1>
|
||
<span class="geneid">Gene ID: 18810, updated on
|
||
8-Feb-2025</span>
|
||
</div>
|
||
<div class="download-datasets">
|
||
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
|
||
<h4 class="download-datasets-popper jig-ncbipopper" id="download-asm" style="align-self:start" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#download-datasets-popper-menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, groupName: 'entrez_pg', adjustFit:'none'" role="button" aria-expanded="false" aria-haspopup="true">
|
||
<svg alt="download" class="dlbtn-icon" x="0px" y="0px" width="15px" height="15px" viewBox="0 0 60 60" enable-background="new 0 0 60 60" xml:space="preserve">
|
||
<g>
|
||
<polygon points="48.75,36.25 48.75,48.75 11.25,48.75 11.25,36.25 5,36.25 5,55 55,55 55,36.25 "></polygon>
|
||
<polygon points="42.5,23.75 36.25,23.75 36.25,5 23.75,5 23.75,23.75 17.5,23.75 30,42.5 "></polygon>
|
||
</g>
|
||
</svg>
|
||
<a href="#">Download Datasets</a>
|
||
</h4>
|
||
<div id="download-datasets-popper-menu" style="display:none;">
|
||
<div class="input-group">
|
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<input type="checkbox" id="datasets-ft-gene-seq-fasta" value="FASTA_GENE" checked="checked" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-gene-seq-fasta">Gene Sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-transcript-seq-fasta">Transcript sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
|
||
</div>
|
||
<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
|
||
<div class="input-group">
|
||
<label for="datasets-download-file-name">File name</label>
|
||
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="Plec_datasets.zip" />
|
||
</div>
|
||
<input type="hidden" id="download-datasets-base-url" value="https://api.ncbi.nlm.nih.gov/datasets/v2alpha/gene/download" />
|
||
<input type="hidden" id="gene-id-value" value="18810" />
|
||
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|
||
<span class="ui-button-text">Download</span>
|
||
</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-body">
|
||
|
||
|
||
<div class="rprt-section gene-summary">
|
||
<section class="rprt-section-header" id="summary">
|
||
<h2 id="header-summary">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Summary</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Summary_2" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div id="summaryDiv" class="section">
|
||
<dl id="summaryDl">
|
||
<dt class="noline"> Official
|
||
Symbol</dt>
|
||
<dd class="noline">Plec<span class="prov">provided by <a href="http://www.informatics.jax.org/mgihome/nomen/" target="_blank" title="Mouse Genome Informatics">MGI</a></span></dd>
|
||
<dt> Official
|
||
Full Name</dt>
|
||
<dd>plectin<span class="prov">provided by <a href="http://www.informatics.jax.org/mgihome/nomen/" target="_blank" title="Mouse Genome Informatics">MGI</a></span></dd>
|
||
<dt>Primary source</dt>
|
||
<dd>
|
||
<a href="http://www.informatics.jax.org/marker/MGI:1277961" data-gblink-text="Ensembl">MGI:MGI:1277961</a>
|
||
</dd>
|
||
<dt>See related</dt>
|
||
<dd>
|
||
<a href="http://www.ensembl.org/id/ENSMUSG00000022565" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSMUSG00000022565">Ensembl:ENSMUSG00000022565</a>
|
||
<a href="https://www.alliancegenome.org/gene/MGI:1277961" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=18810&link_uid=MGI:1277961">AllianceGenome:MGI:1277961</a>
|
||
</dd>
|
||
<dt>Gene type</dt>
|
||
<dd>protein coding</dd>
|
||
<dt>RefSeq status</dt>
|
||
<dd>REVIEWED</dd>
|
||
<dt>Organism</dt>
|
||
<dd class="tax">
|
||
<a href="/Taxonomy/Browser/wwwtax.cgi?id=10090" ref="ordinalpos=1&ncbi_uid=18810&link_uid=10090">Mus musculus</a>
|
||
</dd>
|
||
<dt>Lineage</dt>
|
||
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus</dd>
|
||
<dt>Also known as</dt>
|
||
<dd>PCN; EBS1; PLTN; Plec1</dd>
|
||
<dt>Summary</dt>
|
||
<dd>Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]</dd>
|
||
<dt>Expression</dt>
|
||
<dd>Broad expression in small intestine adult (RPKM 67.8), colon adult (RPKM 65.2) and 22 other tissues <a href="#gene-expression">See more</a></dd>
|
||
<dt>Orthologs</dt>
|
||
<dd class="ortholog-links">
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene/5339">human</a>
|
||
<a href="/gene/5339/ortholog/">all</a>
|
||
</dd>
|
||
<dt style="padding-top:.5em;">
|
||
<span class="new-icon">NEW</span>
|
||
</dt>
|
||
<dd style="padding-top:.5em;">
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/18810/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
|
||
<br />
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/18810/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-genomic-context">
|
||
<section class="rprt-section-header" id="genomic-context">
|
||
<h2 id="header-genomic-context">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic context</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Context" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="gc_cont">
|
||
<div class="gt_cont_contents">
|
||
<div style="float:right"><span>See Plec in </span><a href="/genome/gdv/?context=gene&acc=18810" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001635.27">Genome Data Viewer</a> </div>
|
||
<dl class="dl-chr-info" style="float:left;margin-top:0;">
|
||
<dt>Location: </dt>
|
||
<dd>
|
||
<span style="display:inline-block;">15 D3; 15 35.48 cM</span>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<dl class="dl-chr-info exon-count">
|
||
<dt>Exon count: </dt>
|
||
<dd>44</dd>
|
||
</dl>
|
||
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="">
|
||
<thead>
|
||
<tr>
|
||
<th style="max-width:15%">Annotation release</th>
|
||
<th style="max-width:10%">Status</th>
|
||
<th>Assembly</th>
|
||
<th>
|
||
<span title="Chromosome">Chr</span>
|
||
</th>
|
||
<th>Location</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>RS_2024_02</td>
|
||
<td>current</td>
|
||
<td>GRCm39 (<a href="/assembly/GCF_000001635.27/" ref="ncbi_uid=18810&link_uid=GCF_000001635.27">GCF_000001635.27</a>)</td>
|
||
<td>15</td>
|
||
<td>NC_000081.7 (76055174..76115578, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>108.20200622</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCm38.p6 (<a href="/assembly/GCF_000001635.26/" ref="ncbi_uid=18810&link_uid=GCF_000001635.26">GCF_000001635.26</a>)</td>
|
||
<td>15</td>
|
||
<td>NC_000081.6 (76170974..76231378, complement) </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<p class="withnote margin_t2em"><strong>Chromosome 15 - NC_000081.7</strong><img usemap="#nbrMap18810_1877089954" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=18810&nuc_gi=1877089954&n0=Gm35087&n1=LOC131387755&n2=Gm19945&n3=LOC131387756&n4=Plec&n5=LOC132443667&n6=Mir1942&n7=Parp10&n8=Grina&n9=Mir6953" /><map name="nbrMap18810_1877089954" id="nbrMap18810_1877089954">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'predicted gene, 35087')" onMouseOut="hidetip()" coords="27,23,75,31" alt="Neighboring gene predicted gene, 35087" href="/gene/102638551" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'STARR-seq mESC enhancer starr_39044')" onMouseOut="hidetip()" coords="46,35,116,43" alt="Neighboring gene STARR-seq mESC enhancer starr_39044" href="/gene/131387755" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'STARR-seq mESC enhancer starr_39047')" onMouseOut="hidetip()" coords="87,23,157,31" alt="Neighboring gene STARR-seq mESC enhancer starr_39047" href="/gene/131387756" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'cyclin-dependent kinases regulatory subunit 2 pseudogene')" onMouseOut="hidetip()" coords="90,47,135,55" alt="Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene" href="/gene/102638700" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'STARR-positive B cell enhancer ABC_E5489')" onMouseOut="hidetip()" coords="200,35,270,43" alt="Neighboring gene STARR-positive B cell enhancer ABC_E5489" href="/gene/132443667" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'microRNA 1942')" onMouseOut="hidetip()" coords="284,35,329,43" alt="Neighboring gene microRNA 1942" href="/gene/100316774" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'poly (ADP-ribose) polymerase family, member 10')" onMouseOut="hidetip()" coords="341,35,404,43" alt="Neighboring gene poly (ADP-ribose) polymerase family, member 10" href="/gene/671535" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'microRNA 6953')" onMouseOut="hidetip()" coords="378,23,423,31" alt="Neighboring gene microRNA 6953" href="/gene/102465575" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)')" onMouseOut="hidetip()" coords="387,47,423,55" alt="Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)" href="/gene/66168" />
|
||
</map>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-genomic-regions-transcripts-products">
|
||
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
|
||
<h2 id="header-genomic-regions-transcripts-products">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
|
||
</div>
|
||
<div>
|
||
<p class="choose">
|
||
<label for="accession" class="label">Genomic Sequence: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="10090" data-geneid="18810">
|
||
<option value="NC_000081.7_76055173_76115577">NC_000081.7 Chromosome 15 Reference GRCm39 C57BL/6J</option>
|
||
<option value="NC_000081.6_76170973_76231377">NC_000081.6 Chromosome 15 Reference GRCm38.p6 C57BL/6J</option>
|
||
</select>
|
||
</p>
|
||
</div>
|
||
<div id="NC_000081" class="divAccession">
|
||
<div class="seq-viewer">
|
||
<p class="note-link">
|
||
<strong>Go to nucleotide:</strong>
|
||
<a title="Nucleotide Graphic report" href="/nuccore/NC_000081.7?report=graph&from=76046112&to=76124638&strand=true&app_context=Gene&assm_context=GCF_000001635.27" ref="ordinalpos=1&ncbi_uid=18810&link_uid=NC_000081.7">Graphics</a>
|
||
<a title="Nucleotide FASTA report" href="/nuccore/NC_000081.7?report=fasta&from=76055174&to=76115578&strand=true" ref="ordinalpos=1&ncbi_uid=18810&link_uid=NC_000081.7">FASTA</a>
|
||
<a title="Nucleotide GenBank report" href="/nuccore/NC_000081.7?report=genbank&from=76055174&to=76115578&strand=true" ref="ordinalpos=1&ncbi_uid=18810&link_uid=NC_000081.7">GenBank</a>
|
||
</p>
|
||
<div id="divNC_000081" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&embedded=true&noslider=1&id=NC_000081.7&from=76046112&to=76124638&strand=true&app_context=Gene&assm_context=GCF_000001635.27">
|
||
<a href="?appname=ncbigene&embedded=true&noslider=1&id=NC_000081.7&from=76046112&to=76124638&strand=true&app_context=Gene&assm_context=GCF_000001635.27"></a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000081.7" sid="1" type="hidden" id="nucleotideLink_NC_000081_7_76055173_76115577" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000081.7?report=graph&amp;from=76046112&amp;to=76124638&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001635.27" ref="ordinalpos=1&amp;ncbi_uid=18810&amp;link_uid=NC_000081.7">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000081.7?report=fasta&amp;from=76055174&amp;to=76115578&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=18810&amp;link_uid=NC_000081.7">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000081.7?report=genbank&amp;from=76055174&amp;to=76115578&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=18810&amp;link_uid=NC_000081.7">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000081.7" sid="1" type="hidden" id="relString_NC_000081_7_76055173_76115577" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000081.7&amp;from=76046112&amp;to=76124638&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001635.27" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000081.6" sid="1" type="hidden" id="nucleotideLink_NC_000081_6_76170973_76231377" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000081.6?report=graph&amp;from=76161912&amp;to=76240438&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001635.26" ref="ordinalpos=1&amp;ncbi_uid=18810&amp;link_uid=NC_000081.6">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000081.6?report=fasta&amp;from=76170974&amp;to=76231378&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=18810&amp;link_uid=NC_000081.6">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000081.6?report=genbank&amp;from=76170974&amp;to=76231378&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=18810&amp;link_uid=NC_000081.6">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000081.6" sid="1" type="hidden" id="relString_NC_000081_6_76170973_76231377" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000081.6&amp;from=76161912&amp;to=76240438&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001635.26" />
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-gene-expression">
|
||
<section class="rprt-section-header" id="gene-expression">
|
||
<h2 id="header-gene-expression">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Expression</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">
|
||
<a href="/gene/18810/?report=expression" data-url="/gene/18810/?report=expression" id="gene-expression-see-details">See details</a>
|
||
</div>
|
||
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/18810" data-report-type="summary">
|
||
<div>
|
||
<script type="text/javascript">
|
||
|
||
window.tissues_data = {'liver E14': {'id': '18810_SAMN01164143', 'gene': 18810, 'sample_id': 'SAMN01164143', 'source_name': 'liver E14', 'var': 0.0, 'full_rpkm': 1.11819, 'exp_rpkm': 1.12, 'exp_total': 1650772, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756296}, 'CNS E11.5': {'id': '18810_SAMN01164142', 'gene': 18810, 'sample_id': 'SAMN01164142', 'source_name': 'CNS E11.5', 'var': 0.0, 'full_rpkm': 4.23677, 'exp_rpkm': 4.24, 'exp_total': 5572971, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756297}, 'whole brain E14.5': {'id': '18810_SAMN01164141', 'gene': 18810, 'sample_id': 'SAMN01164141', 'source_name': 'whole brain E14.5', 'var': 0.0, 'full_rpkm': 3.09885, 'exp_rpkm': 3.1, 'exp_total': 3634014, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756298}, 'liver E14.5': {'id': '18810_SAMN01164140', 'gene': 18810, 'sample_id': 'SAMN01164140', 'source_name': 'liver E14.5', 'var': 0.0, 'full_rpkm': 1.13481, 'exp_rpkm': 1.13, 'exp_total': 1154123, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756299}, 'CNS E18': {'id': '18810_SAMN01164139', 'gene': 18810, 'sample_id': 'SAMN01164139', 'source_name': 'CNS E18', 'var': 0.0, 'full_rpkm': 2.88199, 'exp_rpkm': 2.88, 'exp_total': 3709578, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756300}, 'CNS E14': {'id': '18810_SAMN01164138', 'gene': 18810, 'sample_id': 'SAMN01164138', 'source_name': 'CNS E14', 'var': 0.0, 'full_rpkm': 2.87631, 'exp_rpkm': 2.88, 'exp_total': 3817167, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756301}, 'limb E14.5': {'id': '18810_SAMN01164137', 'gene': 18810, 'sample_id': 'SAMN01164137', 'source_name': 'limb E14.5', 'var': 0.0, 'full_rpkm': 8.55006, 'exp_rpkm': 8.55, 'exp_total': 10201876, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756302}, 'cerebellum adult': {'id': '18810_SAMN01164136', 'gene': 18810, 'sample_id': 'SAMN01164136', 'source_name': 'cerebellum adult', 'var': 0.0, 'full_rpkm': 10.403, 'exp_rpkm': 10.4, 'exp_total': 9659731, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756303}, 'liver E18': {'id': '18810_SAMN01164135', 'gene': 18810, 'sample_id': 'SAMN01164135', 'source_name': 'liver E18', 'var': 0.0, 'full_rpkm': 1.99499, 'exp_rpkm': 1.99, 'exp_total': 2998949, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756304}, 'placenta adult': {'id': '18810_SAMN01164134', 'gene': 18810, 'sample_id': 'SAMN01164134', 'source_name': 'placenta adult', 'var': 0.0, 'full_rpkm': 9.61305, 'exp_rpkm': 9.61, 'exp_total': 16079413, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756305}, 'bladder adult': {'id': '18810_SAMN01164133', 'gene': 18810, 'sample_id': 'SAMN01164133', 'source_name': 'bladder adult', 'var': 0.0, 'full_rpkm': 22.0509, 'exp_rpkm': 22.1, 'exp_total': 23547741, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756306}, 'cortex adult': {'id': '18810_SAMN01164132', 'gene': 18810, 'sample_id': 'SAMN01164132', 'source_name': 'cortex adult', 'var': 0.0, 'full_rpkm': 13.9868, 'exp_rpkm': 14.0, 'exp_total': 14544289, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756307}, 'frontal Lobe adult': {'id': '18810_SAMN01164131', 'gene': 18810, 'sample_id': 'SAMN01164131', 'source_name': 'frontal Lobe adult', 'var': 0.0, 'full_rpkm': 11.2125, 'exp_rpkm': 11.2, 'exp_total': 12177941, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756308}, 'heart adult': {'id': '18810_SAMN00849390', 'gene': 18810, 'sample_id': 'SAMN00849390', 'source_name': 'heart adult', 'var': 0.0, 'full_rpkm': 18.9322, 'exp_rpkm': 18.9, 'exp_total': 7630950, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756309}, 'colon adult': {'id': '18810_SAMN00849389', 'gene': 18810, 'sample_id': 'SAMN00849389', 'source_name': 'colon adult', 'var': 0.0, 'full_rpkm': 65.2409, 'exp_rpkm': 65.2, 'exp_total': 24200687, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756310}, 'spleen adult': {'id': '18810_SAMN00849388', 'gene': 18810, 'sample_id': 'SAMN00849388', 'source_name': 'spleen adult', 'var': 0.0, 'full_rpkm': 18.643, 'exp_rpkm': 18.6, 'exp_total': 8959870, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756311}, 'lung adult': {'id': '18810_SAMN00849387', 'gene': 18810, 'sample_id': 'SAMN00849387', 'source_name': 'lung adult', 'var': 0.0, 'full_rpkm': 32.5191, 'exp_rpkm': 32.5, 'exp_total': 11689512, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756312}, 'liver adult': {'id': '18810_SAMN00849386', 'gene': 18810, 'sample_id': 'SAMN00849386', 'source_name': 'liver adult', 'var': 0.0, 'full_rpkm': 6.31503, 'exp_rpkm': 6.32, 'exp_total': 3229438, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756313}, 'kidney adult': {'id': '18810_SAMN00849385', 'gene': 18810, 'sample_id': 'SAMN00849385', 'source_name': 'kidney adult', 'var': 0.0, 'full_rpkm': 8.11441, 'exp_rpkm': 8.11, 'exp_total': 4667705, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756314}, 'testis adult': {'id': '18810_SAMN00849384', 'gene': 18810, 'sample_id': 'SAMN00849384', 'source_name': 'testis adult', 'var': 0.0, 'full_rpkm': 34.916, 'exp_rpkm': 34.9, 'exp_total': 14454721, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756315}, 'thymus adult': {'id': '18810_SAMN00849383', 'gene': 18810, 'sample_id': 'SAMN00849383', 'source_name': 'thymus adult', 'var': 0.0, 'full_rpkm': 20.094, 'exp_rpkm': 20.1, 'exp_total': 10474072, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756316}, 'subcutaneous fat pad adult': {'id': '18810_SAMN00849382', 'gene': 18810, 'sample_id': 'SAMN00849382', 'source_name': 'subcutaneous fat pad adult', 'var': 0.0, 'full_rpkm': 16.6617, 'exp_rpkm': 16.7, 'exp_total': 7259289, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756317}, 'genital fat pad adult': {'id': '18810_SAMN00849381', 'gene': 18810, 'sample_id': 'SAMN00849381', 'source_name': 'genital fat pad adult', 'var': 0.0, 'full_rpkm': 12.313, 'exp_rpkm': 12.3, 'exp_total': 5355729, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756318}, 'Large Intestine adult': {'id': '18810_SAMN00849380', 'gene': 18810, 'sample_id': 'SAMN00849380', 'source_name': 'Large Intestine adult', 'var': 0.0, 'full_rpkm': 31.0132, 'exp_rpkm': 31.0, 'exp_total': 13484425, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756319}, 'adrenal adult': {'id': '18810_SAMN00849379', 'gene': 18810, 'sample_id': 'SAMN00849379', 'source_name': 'adrenal adult', 'var': 0.0, 'full_rpkm': 18.5258, 'exp_rpkm': 18.5, 'exp_total': 7319842, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756320}, 'duodenum adult': {'id': '18810_SAMN00849378', 'gene': 18810, 'sample_id': 'SAMN00849378', 'source_name': 'duodenum adult', 'var': 0.0, 'full_rpkm': 36.2097, 'exp_rpkm': 36.2, 'exp_total': 14237259, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756321}, 'small intestine adult': {'id': '18810_SAMN00849377', 'gene': 18810, 'sample_id': 'SAMN00849377', 'source_name': 'small intestine adult', 'var': 0.0, 'full_rpkm': 67.8106, 'exp_rpkm': 67.8, 'exp_total': 27156527, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756322}, 'stomach adult': {'id': '18810_SAMN00849376', 'gene': 18810, 'sample_id': 'SAMN00849376', 'source_name': 'stomach adult', 'var': 0.0, 'full_rpkm': 24.2383, 'exp_rpkm': 24.2, 'exp_total': 11054050, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756323}, 'mammary gland adult': {'id': '18810_SAMN00849375', 'gene': 18810, 'sample_id': 'SAMN00849375', 'source_name': 'mammary gland adult', 'var': 0.0, 'full_rpkm': 30.1135, 'exp_rpkm': 30.1, 'exp_total': 11453204, 'project_desc': 'PRJNA66167', '_version_': 1785731968991756324}, 'ovary adult': {'id': '18810_SAMN00849374', 'gene': 18810, 'sample_id': 'SAMN00849374', 'source_name': 'ovary adult', 'var': 0.0, 'full_rpkm': 43.1943, 'exp_rpkm': 43.2, 'exp_total': 12796605, 'project_desc': 'PRJNA66167', '_version_': 1785731968992804864}};
|
||
|
||
|
||
|
||
|
||
window.details_data = {"CNS E11.5": [{"id": "metadata_10090_SAMN01164142", "gene": 18810, "sample_id": "SAMN01164142", "source_name": "CNS E11.5", "var": 0.0, "full_rpkm": 4.23677, "exp_rpkm": 4.24, "exp_total": 5572971, "project_desc": "PRJNA66167", "_version_": 1785731958042525696, "is_metadata": true, "is_sample": true, "taxid": 10090, "exp_Mcount": 75100.3}], "CNS E14": [{"id": "metadata_10090_SAMN01164138", "gene": 18810, "sample_id": "SAMN01164138", "source_name": "CNS E14", "var": 0.0, "full_rpkm": 2.87631, "exp_rpkm": 2.88, "exp_total": 3817167, "project_desc": "PRJNA66167", "_version_": 1785731958050914304, "is_metadata": true, "is_sample": true, "taxid": 10090, "exp_Mcount": 75769.7}], "CNS E18": [{"id": "metadata_10090_SAMN01164139", "gene": 18810, "sample_id": "SAMN01164139", "source_name": "CNS E18", "var": 0.0, "full_rpkm": 2.88199, "exp_rpkm": 2.88, "exp_total": 3709578, "project_desc": "PRJNA66167", "_version_": 1785731958048817152, "is_metadata": true, "is_sample": 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|
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<option value="iSRP012040" selected="selected" data-bioproject="PRJNA66167">
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Mouse ENCODE transcriptome data
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Mouse ENCODE transcriptome data
|
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<li id="project-summary-desc">Description: RNA profiling data sets generated by the Mouse ENCODE project.</li>
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<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA66167/">PRJNA66167</a>
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|
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<li id="project-summary-pubs">Publication:
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||
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||
<span><a href="/pubmed/25409824/">PMID 25409824</a></span>
|
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||
</li>
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||
<li id="project-summary-analysis-date">Analysis date: n/a</li>
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|
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</ul>
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<div id="gene-expr-details" class="expression-chart"></div>
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<script type="text/javascript" src="https://www.gstatic.com/charts/loader.js"></script>
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<div class="rprt-section gene-bibliography">
|
||
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
<div class="rprt-section-body" style="">
|
||
<div class="generif-pubmed">
|
||
<h3 id="relatedarticlesinpubmed">
|
||
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
|
||
</h3>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li>
|
||
<a href="/pubmed/24487589/" ref="ordinalpos=1&ncbi_uid=18810&link_uid=24487589">Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle.</a>
|
||
<span class="pubmed-auth-date"> Winter L, <em>et al</em>. J Clin Invest, 2014 Mar. PMID 24487589, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC3934181/" ref="ordinalpos=0&ncbi_uid=18810&link_uid=PMC3934181">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/9389647/" ref="ordinalpos=2&ncbi_uid=18810&link_uid=9389647">Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture.</a>
|
||
<span class="pubmed-auth-date"> Andrä K, <em>et al</em>. Genes Dev, 1997 Dec 1. PMID 9389647, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC316746/" ref="ordinalpos=0&ncbi_uid=18810&link_uid=PMC316746">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/22144912/" ref="ordinalpos=3&ncbi_uid=18810&link_uid=22144912">Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna.</a>
|
||
<span class="pubmed-auth-date"> Walko G, <em>et al</em>. PLoS Genet, 2011 Dec. PMID 22144912, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC3228830/" ref="ordinalpos=0&ncbi_uid=18810&link_uid=PMC3228830">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/23363598/" ref="ordinalpos=4&ncbi_uid=18810&link_uid=23363598">Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes.</a>
|
||
<span class="pubmed-auth-date"> Valencia RG, <em>et al</em>. Mol Biol Cell, 2013 Mar. PMID 23363598, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC3596248/" ref="ordinalpos=0&ncbi_uid=18810&link_uid=PMC3596248">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/19244477/" ref="ordinalpos=5&ncbi_uid=18810&link_uid=19244477">Plectin contributes to mechanical properties of living cells.</a>
|
||
<span class="pubmed-auth-date"> Na S, <em>et al</em>. Am J Physiol Cell Physiol, 2009 Apr. PMID 19244477, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC2670656/" ref="ordinalpos=0&ncbi_uid=18810&link_uid=PMC2670656">Free PMC Article</a></span></span>
|
||
</li>
|
||
</ol>
|
||
<p class="see-all-pm">
|
||
<a href="/pubmed?LinkName=gene_pubmed&from_uid=18810" title="See all 117 citations in Pubmed">See all (117) citations in PubMed</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="generif-pubmed generif">
|
||
<h3 id="generifsgenereferencesintofunctions">
|
||
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
|
||
</h3>
|
||
<div>
|
||
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38263015" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=38263015">Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma.</a>
|
||
<div id="gene-popper1" class="gene-rif-popper">Title: Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37393735" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=37393735">Novel biallelic variants in the PLEC gene are associated with severe hearing loss.</a>
|
||
<div id="gene-popper2" class="gene-rif-popper">Title: Novel biallelic variants in the PLEC gene are associated with severe hearing loss.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/33674761" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=33674761">Plectin ensures intestinal epithelial integrity and protects colon against colitis.</a>
|
||
<div id="gene-popper3" class="gene-rif-popper">Title: Plectin ensures intestinal epithelial integrity and protects colon against colitis.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/33705811" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=33705811">Plectin regulates Wnt signaling mediated-skeletal muscle development by interacting with Dishevelled-2 and antagonizing autophagy.</a>
|
||
<div id="gene-popper4" class="gene-rif-popper">Title: Plectin regulates Wnt signaling mediated-skeletal muscle development by interacting with Dishevelled-2 and antagonizing autophagy.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/29273475" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=29273475">Our study shows that by maintaining proper keratin network cytoarchitecture and biliary epithelial stability, plectin plays a critical role in protecting the liver from stress elicited by cholestasis.</a>
|
||
<div id="gene-popper5" class="gene-rif-popper">Title: Plectin controls biliary tree architecture and stability in cholestasis.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/26527396" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26527396">data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and protects the nucleus from mechanical deformation.</a>
|
||
<div id="gene-popper6" class="gene-rif-popper">Title: The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/25971800" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=25971800">Data demonstrate that rodless plectin can functionally compensate for the loss of full-length plectin in mice.</a>
|
||
<div id="gene-popper7" class="gene-rif-popper">Title: The rod domain is not essential for the function of plectin in maintaining tissue integrity.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/26019234" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26019234">results show that the depletion of distinct plectin isoforms affects mitochondrial network organization and function in different ways.</a>
|
||
<div id="gene-popper8" class="gene-rif-popper">Title: Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/25703379" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=25703379">Binding of calcium-calmodulin (Ca(2+)-CaM) to P1a together with phosphorylation of integrin beta 4 disrupts the complex, resulting in disassembly of hemidesmosomes.</a>
|
||
<div id="gene-popper9" class="gene-rif-popper">Title: Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin β4 interaction in hemidesmosomes.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/25318670" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=18810&link_uid=25318670">Plectin bridges acetylcholine receptors and intermediate filaments via direct interaction with the AChR-scaffolding protein rapsyn in an isoform-specific manner.</a>
|
||
<div id="gene-popper10" class="gene-rif-popper">Title: Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes.</div>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<div class="submit-genrif">
|
||
<span>Submit:</span>
|
||
<a href="/gene/submit-generif/?geneId=18810&sym=Plec&name=plectin&org=Mus musculus">New GeneRIF</a>
|
||
<a href="/RefSeq/update.cgi?geneid=18810&symbol=Plec;task=fixpub">Correction</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&report=generif&term=18810" class="seeall-generif">See all GeneRIFs (32)</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-variation">
|
||
<section class="rprt-section-header" id="variation">
|
||
<h2 id="header-variation">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Variation</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="infosec alleles-subsec">
|
||
<h3 id="alleles">
|
||
<a class="jig-ncbitoggler-open">Alleles</a>
|
||
</h3>
|
||
<div class="geneinfo-subsec">
|
||
<div>Alleles of this type are documented at Mouse Genome Informatics <a title="" href="http://www.informatics.jax.org/allele/summary?markerId=MGI:1277961">(MGI)</a></div>
|
||
<ul class="geneinfo-subsec">
|
||
<li>Endonuclease-mediated (5)
|
||
</li>
|
||
<li>Gene trapped (1)
|
||
<a title="PubMed ID 12904583" href="/pubmed/12904583">1 citation</a></li>
|
||
<li>Targeted (9)
|
||
<a title="PubMed ID 16344482,17606998,18490514,19625254,22144912,9389647" href="/pubmed/16344482,17606998,18490514,19625254,22144912,9389647">1 citation</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
<set></set>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-pathways">
|
||
<section class="rprt-section-header" id="pathways">
|
||
<h2 id="header-pathways">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<ul class="geneinfo-subsec infopathway">
|
||
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/18810#section=Pathways&embed=true&hide_all_headings=true&page_size=25" style="border: 0; width: 100%;"></iframe>
|
||
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
|
||
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-interactions">
|
||
<section class="rprt-section-header" id="interactions">
|
||
<h2 id="header-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/18810/data/interaction/',webserviceParams: 'p$l=Ajax&p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th id="inter-prod">Products</th>
|
||
<th id="inter-interactant">Interactant</th>
|
||
<th id="inter-otherGene">Other Gene</th>
|
||
<th id="inter-compl">Complex</th>
|
||
<th id="inter-source">Source</th>
|
||
<th id="inter-pubs">Pubs</th>
|
||
<th id="inter-desc">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-general-gene-info">
|
||
<section class="rprt-section-header" id="general-gene-info">
|
||
<h2 id="header-general-gene-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General gene information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="gene-markers">
|
||
<h3 id="markers">
|
||
<a class="jig-ncbitoggler">Markers</a>
|
||
</h3>
|
||
<div>
|
||
<ul class="marker odd">
|
||
<li class="marker">Plec1 (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=158753%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=18810&link_uid=158753">UniSTS:158753</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH129479 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=212785%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=18810&link_uid=212785">UniSTS:212785</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">RH125037 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=161859%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=18810&link_uid=161859">UniSTS:161859</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">G46074 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=106876%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=18810&link_uid=106876">UniSTS:106876</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">AU042537 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=160466%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=18810&link_uid=160466">UniSTS:160466</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH118359 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=160986%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=18810&link_uid=160986">UniSTS:160986</a></li></ul></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div></div>
|
||
|
||
<div class="infosec">
|
||
<h3 id="homology">
|
||
<a class="jig-ncbitoggler-open">Homology</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>
|
||
<a href="/gene/18810/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
|
||
</li>
|
||
<a href="https://www.orthodb.org/?ncbi=18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=8178" target="_blank">
|
||
Orthologs from OrthoDB
|
||
</a>
|
||
</ul>
|
||
</div>
|
||
|
||
<!--<component id="Gene_InfoPathway"/>-->
|
||
|
||
|
||
<div class="gene-ontology infosec">
|
||
<h3 id="gene-ontology">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Gene Ontology</span>
|
||
</a>
|
||
<a target="_blank" href="http://www.informatics.jax.org" class="g-ontology-src" title="Provided by MGI">Provided by MGI</a>
|
||
</h3>
|
||
<div class="ontology-tables">
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Function</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003779">enables actin binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10556294" target="_blank" title="PubMed ID 10556294" ref="ordinalpos=1&ncbi_uid=18810&link_uid=10556294">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0051015">enables actin filament binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-2-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9808630" target="_blank" title="PubMed ID 9808630" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9808630">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030506">enables ankyrin binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-3-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030506">enables ankyrin binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-4-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030506">enables ankyrin binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-5-0" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008092">enables cytoskeletal protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-6-0" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002162">enables dystroglycan binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-7-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/23836526" target="_blank" title="PubMed ID 23836526" ref="ordinalpos=1&ncbi_uid=18810&link_uid=23836526">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042802">enables identical protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-8-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/22144912" target="_blank" title="PubMed ID 22144912" ref="ordinalpos=1&ncbi_uid=18810&link_uid=22144912">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-9-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12200133,15128297,16608880,17389230,18827015,19932097,24940650,25703379,29128334" target="_blank" title="PubMed ID 12200133,15128297,16608880,17389230,18827015,19932097,24940650,25703379,29128334" ref="ordinalpos=1&ncbi_uid=18810&link_uid=12200133,15128297,16608880,17389230,18827015,19932097,24940650,25703379,29128334">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005200">enables structural constituent of cytoskeleton</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-10-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005200">enables structural constituent of cytoskeleton</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-11-0" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008307">enables structural constituent of muscle</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-12-0" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Process</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0010818">involved_in T cell chemotaxis</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-1-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16344482" target="_blank" title="PubMed ID 16344482" ref="ordinalpos=1&ncbi_uid=18810&link_uid=16344482">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030036">involved_in actin cytoskeleton organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-2-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9808630,16344482" target="_blank" title="PubMed ID 9808630,16344482" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9808630,16344482">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007015">involved_in actin filament organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-3-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26519478" target="_blank" title="PubMed ID 26519478" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26519478">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:2000689">involved_in actomyosin contractile ring assembly actin filament organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-4-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26519478" target="_blank" title="PubMed ID 26519478" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26519478">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0034332">involved_in adherens junction organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-5-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26519478" target="_blank" title="PubMed ID 26519478" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26519478">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0055013">involved_in cardiac muscle cell development</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-6-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9389647" target="_blank" title="PubMed ID 9389647" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9389647">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0000902">involved_in cell morphogenesis</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-7-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9808630" target="_blank" title="PubMed ID 9808630" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9808630">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0048870">involved_in cell motility</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-8-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9808630" target="_blank" title="PubMed ID 9808630" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9808630">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0071498">involved_in cellular response to fluid shear stress</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-9-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9808630" target="_blank" title="PubMed ID 9808630" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9808630">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0071464">involved_in cellular response to hydrostatic pressure</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-10-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/25447312" target="_blank" title="PubMed ID 25447312" ref="ordinalpos=1&ncbi_uid=18810&link_uid=25447312">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0071260">involved_in cellular response to mechanical stimulus</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-11-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26519478" target="_blank" title="PubMed ID 26519478" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26519478">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0051716">involved_in cellular response to stimulus</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-12-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9808630" target="_blank" title="PubMed ID 9808630" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9808630">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0061436">involved_in establishment of skin barrier</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-13-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17606998" target="_blank" title="PubMed ID 17606998" ref="ordinalpos=1&ncbi_uid=18810&link_uid=17606998">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0010761">involved_in fibroblast migration</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-14-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16344482" target="_blank" title="PubMed ID 16344482" ref="ordinalpos=1&ncbi_uid=18810&link_uid=16344482">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0010467">involved_in gene expression</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-15-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19932097,24487589" target="_blank" title="PubMed ID 19932097,24487589" ref="ordinalpos=1&ncbi_uid=18810&link_uid=19932097,24487589">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0031581">involved_in hemidesmosome assembly</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-16-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0031581">involved_in hemidesmosome assembly</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-17-1" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0031581">involved_in hemidesmosome assembly</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-18-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045104">involved_in intermediate filament cytoskeleton organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-19-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045104">involved_in intermediate filament cytoskeleton organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-20-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23836526" target="_blank" title="PubMed ID 23836526" ref="ordinalpos=1&ncbi_uid=18810&link_uid=23836526">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045109">involved_in intermediate filament organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-21-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18490514,18541706,24487589,26487297,26519478" target="_blank" title="PubMed ID 18490514,18541706,24487589,26487297,26519478" ref="ordinalpos=1&ncbi_uid=18810&link_uid=18490514,18541706,24487589,26487297,26519478">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003334">involved_in keratinocyte development</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-22-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17606998" target="_blank" title="PubMed ID 17606998" ref="ordinalpos=1&ncbi_uid=18810&link_uid=17606998">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030216">involved_in keratinocyte differentiation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-23-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-23-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/25447312" target="_blank" title="PubMed ID 25447312" ref="ordinalpos=1&ncbi_uid=18810&link_uid=25447312">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002522">involved_in leukocyte migration involved in immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-24-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-24-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16344482" target="_blank" title="PubMed ID 16344482" ref="ordinalpos=1&ncbi_uid=18810&link_uid=16344482">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007005">involved_in mitochondrion organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-25-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-25-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18490514,18541706" target="_blank" title="PubMed ID 18490514,18541706" ref="ordinalpos=1&ncbi_uid=18810&link_uid=18490514,18541706">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0035264">involved_in multicellular organism growth</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-26-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-26-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17606998" target="_blank" title="PubMed ID 17606998" ref="ordinalpos=1&ncbi_uid=18810&link_uid=17606998">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0022011">involved_in myelination in peripheral nervous system</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-27-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-27-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19625254" target="_blank" title="PubMed ID 19625254" ref="ordinalpos=1&ncbi_uid=18810&link_uid=19625254">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045445">involved_in myoblast differentiation</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-28-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-28-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/25447312" target="_blank" title="PubMed ID 25447312" ref="ordinalpos=1&ncbi_uid=18810&link_uid=25447312">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006469">involved_in negative regulation of protein kinase activity</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-29-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-29-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12200133" target="_blank" title="PubMed ID 12200133" ref="ordinalpos=1&ncbi_uid=18810&link_uid=12200133">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006997">involved_in nucleus organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-30-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-30-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26487297" target="_blank" title="PubMed ID 26487297" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26487297">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032287">involved_in peripheral nervous system myelin maintenance</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-31-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-31-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23836526" target="_blank" title="PubMed ID 23836526" ref="ordinalpos=1&ncbi_uid=18810&link_uid=23836526">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0008104">involved_in protein localization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-32-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-32-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16608880" target="_blank" title="PubMed ID 16608880" ref="ordinalpos=1&ncbi_uid=18810&link_uid=16608880">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043933">involved_in protein-containing complex organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-33-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-33-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16608880" target="_blank" title="PubMed ID 16608880" ref="ordinalpos=1&ncbi_uid=18810&link_uid=16608880">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:2000983">involved_in regulation of ATP citrate synthase activity</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-34-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-34-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26019234" target="_blank" title="PubMed ID 26019234" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26019234">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043114">involved_in regulation of vascular permeability</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-35-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-35-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26519478" target="_blank" title="PubMed ID 26519478" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26519478">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0022904">involved_in respiratory electron transport chain</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-36-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-36-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26019234" target="_blank" title="PubMed ID 26019234" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26019234">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0032094">involved_in response to food</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-37-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-37-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17606998" target="_blank" title="PubMed ID 17606998" ref="ordinalpos=1&ncbi_uid=18810&link_uid=17606998">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007584">involved_in response to nutrient</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-38-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-38-1" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045214">involved_in sarcomere organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-39-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-39-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24487589" target="_blank" title="PubMed ID 24487589" ref="ordinalpos=1&ncbi_uid=18810&link_uid=24487589">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0048741">involved_in skeletal muscle fiber development</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-40-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-40-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/18490514,24487589" target="_blank" title="PubMed ID 18490514,24487589" ref="ordinalpos=1&ncbi_uid=18810&link_uid=18490514,24487589">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007519">involved_in skeletal muscle tissue development</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-41-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-41-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9389647" target="_blank" title="PubMed ID 9389647" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9389647">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0014866">involved_in skeletal myofibril assembly</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-42-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-42-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24487589" target="_blank" title="PubMed ID 24487589" ref="ordinalpos=1&ncbi_uid=18810&link_uid=24487589">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043588">involved_in skin development</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-43-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-43-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9389647,17606998" target="_blank" title="PubMed ID 9389647,17606998" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9389647,17606998">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0120193">involved_in tight junction organization</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-44-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-44-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26519478" target="_blank" title="PubMed ID 26519478" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26519478">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019226">involved_in transmission of nerve impulse</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-45-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-45-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19625254" target="_blank" title="PubMed ID 19625254" ref="ordinalpos=1&ncbi_uid=18810&link_uid=19625254">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042060">involved_in wound healing</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-46-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-46-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Component</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030018">is_active_in Z disc</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/17389230" target="_blank" title="PubMed ID 17389230" ref="ordinalpos=1&ncbi_uid=18810&link_uid=17389230">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0016324">located_in apical plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-2-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030424">is_active_in axon</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-3-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19625254" target="_blank" title="PubMed ID 19625254" ref="ordinalpos=1&ncbi_uid=18810&link_uid=19625254">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009925">located_in basal plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-4-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005903">located_in brush border</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-5-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/22114352" target="_blank" title="PubMed ID 22114352" ref="ordinalpos=1&ncbi_uid=18810&link_uid=22114352">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0071944">is_active_in cell periphery</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9389647" target="_blank" title="PubMed ID 9389647" ref="ordinalpos=1&ncbi_uid=18810&link_uid=9389647">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043292">located_in contractile muscle fiber</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-7-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/14627610" target="_blank" title="PubMed ID 14627610" ref="ordinalpos=1&ncbi_uid=18810&link_uid=14627610">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">is_active_in cytoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-8-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">is_active_in cytoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-9-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/23836526" target="_blank" title="PubMed ID 23836526" ref="ordinalpos=1&ncbi_uid=18810&link_uid=23836526">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-10-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-11-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030425">is_active_in dendrite</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-12-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19625254" target="_blank" title="PubMed ID 19625254" ref="ordinalpos=1&ncbi_uid=18810&link_uid=19625254">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005925">is_active_in focal adhesion</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-13-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005925">located_in focal adhesion</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-14-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005925">located_in focal adhesion</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-15-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030056">is_active_in hemidesmosome</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-16-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030056">is_active_in hemidesmosome</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-17-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/22144912" target="_blank" title="PubMed ID 22144912" ref="ordinalpos=1&ncbi_uid=18810&link_uid=22144912">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030056">located_in hemidesmosome</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-18-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030056">located_in hemidesmosome</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-19-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005882">colocalizes_with intermediate filament</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-20-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045111">located_in intermediate filament cytoskeleton</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-21-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045111">located_in intermediate filament cytoskeleton</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-22-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005741">is_active_in mitochondrial outer membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-23-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-23-2" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/18541706" target="_blank" title="PubMed ID 18541706" ref="ordinalpos=1&ncbi_uid=18810&link_uid=18541706">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0043209">is_active_in myelin sheath</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-24-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-24-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/19625254" target="_blank" title="PubMed ID 19625254" ref="ordinalpos=1&ncbi_uid=18810&link_uid=19625254">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0030016">is_active_in myofibril</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-25-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-25-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/26019234" target="_blank" title="PubMed ID 26019234" ref="ordinalpos=1&ncbi_uid=18810&link_uid=26019234">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0048471">is_active_in perinuclear region of cytoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-26-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-26-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0048471">located_in perinuclear region of cytoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-27-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-27-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002102">located_in podosome</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-28-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-28-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/23525008" target="_blank" title="PubMed ID 23525008" ref="ordinalpos=1&ncbi_uid=18810&link_uid=23525008">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042383">is_active_in sarcolemma</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-29-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-29-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042383">is_active_in sarcolemma</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-30-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-30-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/17389230" target="_blank" title="PubMed ID 17389230" ref="ordinalpos=1&ncbi_uid=18810&link_uid=17389230">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042383">located_in sarcolemma</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-31-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-31-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042383">located_in sarcolemma</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-32-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-32-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0016528">located_in sarcoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-33-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISO</a>
|
||
<div id="evidence-code-33-2" class="ecode">Inferred from Sequence Orthology<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-general-protein-info">
|
||
<section class="rprt-section-header" id="general-protein-info">
|
||
<h2 id="header-general-protein-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General protein information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<dl>
|
||
<dt>Preferred Names</dt>
|
||
<dd>plectin</dd>
|
||
</dl>
|
||
<dl>
|
||
<dt>Names</dt>
|
||
<dd>plectin-1</dd>
|
||
<dd>plectin-6</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-reference-sequences">
|
||
<section class="rprt-section-header" id="reference-sequences">
|
||
<h2 id="header-reference-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p>
|
||
<span class="new-icon">NEW</span>
|
||
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&ids=18810&utm_source=gene&utm_medium=referral&utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
|
||
</p>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
|
||
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
|
||
Genomes</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
|
||
<p id="refseq-expl"> These reference sequences are curated independently of the genome
|
||
annotation cycle, so their versions may not match the RefSeq versions in the current
|
||
genome build. Identify version mismatches by comparing the version of the RefSeq in
|
||
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
|
||
transcripts, and products</a> above. </p>
|
||
<h4 id="mrnaandproteins-p109091664">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001163540.1">NM_001163540.1</a> → <a href="/protein/NP_001157012.1">NP_001157012.1</a> plectin isoform 12alpha</p>
|
||
<p>
|
||
<a href="/ipg/NP_001157012.1/" ref="ncbi_uid=18810">See identical proteins and their annotated locations for NP_001157012.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (13), also known as 12alpha, differs in the 5' UTR and the 5' coding region, and contains an additional in-frame coding exon compared to variant 1. The resulting protein (isoform 12alpha) contains a distinct N-terminus and contains a 5 aa internal protein segment compared to isoform 1c. This variant (13) contains the same 5' coding exon as variant 6 but also contains an alternate in-frame exon so the resulting protein contains a 5aa internal segment compared to isoform 1.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AF188008, AI464512, AY480033, CN669707">AF188008, AI464512, AY480033, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS49647.1">CCDS49647.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/E9QN87" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">E9QN87</a>, <a href="https://www.uniprot.org/uniprot/Q6S384" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S384</a>, <a href="https://www.uniprot.org/uniprot/Q6S389" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S389</a>, <a href="https://www.uniprot.org/uniprot/Q6S394" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S394</a>, <a href="https://www.uniprot.org/uniprot/Q9CS65" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9CS65</a>, <a href="https://www.uniprot.org/uniprot/Q9QUT2" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QUT2</a>, <a href="https://www.uniprot.org/uniprot/Q9QXQ8" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXQ8</a>, <a href="https://www.uniprot.org/uniprot/Q9QXQ9" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXQ9</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR0" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR0</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR1" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR1</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR2" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR2</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR3" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR3</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR4" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR4</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR5" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR5</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR6" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR6</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR7" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR7</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR8" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR8</a>, <a href="https://www.uniprot.org/uniprot/Q9QXR9" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXR9</a>, <a href="https://www.uniprot.org/uniprot/Q9QXS0" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXS0</a>, <a href="https://www.uniprot.org/uniprot/Q9QXS1" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXS1</a>, <a href="https://www.uniprot.org/uniprot/Q9QXS2" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXS2</a>, <a href="https://www.uniprot.org/uniprot/Q9QXS3" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q9QXS3</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S388" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S388</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000073124.7" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000073124.7</a>, <a href="http://www.ensembl.org/id/ENSMUST00000073418.13" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000073418.13</a></dd>
|
||
<dt class="clear"> Conserved Domains (12) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001157012.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">667</span> → <span class="cddto">761</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3238</span> → <span class="cddto">3274</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">186</span> → <span class="cddto">293</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">763</span> → <span class="cddto">941</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">308</span> → <span class="cddto">406</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2948</span> → <span class="cddto">2989</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1526</span> → <span class="cddto">2713</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=281497">pfam03501</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">7</span> → <span class="cddto">101</span></dt>
|
||
<dd class="clearfix"> S10_plectin; Plectin/S10 domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2477</span> → <span class="cddto">2490</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=295325">cl02488</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1871</span> → <span class="cddto">2046</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2326</span> → <span class="cddto">2510</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1620</span> → <span class="cddto">1743</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001163542.1">NM_001163542.1</a> → <a href="/protein/NP_001157014.1">NP_001157014.1</a> plectin isoform 1c2alpha3alpha</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (15), also known as 1c2alpha3alpha, contains two alternate in-frame exons compared to variant 1. This results in a protein (isoform 1c2alpha3alpha) with two internal protein segments (5 and 12 aa, respectively) compared to isoform 1c.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AF188013, AI464512, AY480033, CN669707">AF188013, AI464512, AY480033, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS49649.1">CCDS49649.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S392" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S392</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000087037.4" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000087037.4</a>, <a href="http://www.ensembl.org/id/ENSMUST00000089610.10" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000089610.10</a></dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001157014.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">565</span> → <span class="cddto">659</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3136</span> → <span class="cddto">3172</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">72</span> → <span class="cddto">191</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">661</span> → <span class="cddto">839</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">206</span> → <span class="cddto">304</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2846</span> → <span class="cddto">2887</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1424</span> → <span class="cddto">2611</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2375</span> → <span class="cddto">2388</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2224</span> → <span class="cddto">2408</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1518</span> → <span class="cddto">1641</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001163549.1">NM_001163549.1</a> → <a href="/protein/NP_001157021.1">NP_001157021.1</a> plectin isoform 1b2alpha</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (14), also known as 1b2alpha, differs in the 5' UTR and the 5' coding region, and contains an additional in-frame coding exon compared to variant 1. The resulting protein (isoform 1b2alpha) contains a distinct N-terminus and contains a 5 aa internal protein segment compared to isoform 1c. This variant (14) contains the same 5' coding exon as variant 8 but also contains an alternate in-frame exon so the resulting protein contains a 5aa internal segment compared to isoform 1b.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AF188011, AI464512, AY480033, CN669707">AF188011, AI464512, AY480033, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS49645.1">CCDS49645.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S387" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S387</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000057158.8" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000057158.8</a>, <a href="http://www.ensembl.org/id/ENSMUST00000054449.14" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000054449.14</a></dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001157021.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">524</span> → <span class="cddto">618</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3095</span> → <span class="cddto">3131</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">43</span> → <span class="cddto">150</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">620</span> → <span class="cddto">798</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">165</span> → <span class="cddto">263</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2805</span> → <span class="cddto">2846</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1383</span> → <span class="cddto">2570</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2334</span> → <span class="cddto">2347</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2183</span> → <span class="cddto">2367</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1477</span> → <span class="cddto">1600</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001164203.1">NM_001164203.1</a> → <a href="/protein/NP_001157675.1">NP_001157675.1</a> plectin isoform 1hij</p>
|
||
<p>
|
||
<a href="/ipg/NP_001157675.1/" ref="ncbi_uid=18810">See identical proteins and their annotated locations for NP_001157675.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (12), also known as 1j2alpha3alpha, contains an alternate 5' terminal exon and additional exons which result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5, 9 and 12 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC110211, AF188023, AY480037">AC110211, AF188023, AY480037</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS37117.2">CCDS37117.2</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/E9Q3W4" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">E9Q3W4</a>, <a href="https://www.uniprot.org/uniprot/Q6S390" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S390</a></dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000079668.6" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000079668.6</a>, <a href="http://www.ensembl.org/id/ENSMUST00000080857.12" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000080857.12</a></dd>
|
||
<dt class="clear"> Conserved Domains (9) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001157675.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">362</span> → <span class="cddto">456</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2933</span> → <span class="cddto">2969</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">458</span> → <span class="cddto">636</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">101</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2643</span> → <span class="cddto">2684</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1221</span> → <span class="cddto">2408</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2172</span> → <span class="cddto">2185</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2088</span> → <span class="cddto">2205</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1315</span> → <span class="cddto">1438</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_011117.2">NM_011117.2</a> → <a href="/protein/NP_035247.2">NP_035247.2</a> plectin isoform 1c</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (1) contains the 5'-most coding exon (exon 1c) and encodes isoform 1c.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AI464512, AY480033, CN669707">AI464512, AY480033, CN669707</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S392" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S392</a>
|
||
</dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_035247.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">548</span> → <span class="cddto">642</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3119</span> → <span class="cddto">3155</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">72</span> → <span class="cddto">174</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">644</span> → <span class="cddto">822</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">189</span> → <span class="cddto">287</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2829</span> → <span class="cddto">2870</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1407</span> → <span class="cddto">2594</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2358</span> → <span class="cddto">2371</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2207</span> → <span class="cddto">2391</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1501</span> → <span class="cddto">1624</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201385.2">NM_201385.2</a> → <a href="/protein/NP_958787.2">NP_958787.2</a> plectin isoform 1f</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (2), also known as 1f, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1f) contains a distinct N-terminus compared to isoform 1c.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AI464512, AY480034, CN669707">AI464512, AY480034, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS37113.1">CCDS37113.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S393" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S393</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000074383.6" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000074383.6</a>, <a href="http://www.ensembl.org/id/ENSMUST00000074834.12" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000074834.12</a></dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958787.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">510</span> → <span class="cddto">604</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3081</span> → <span class="cddto">3117</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">34</span> → <span class="cddto">136</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">606</span> → <span class="cddto">784</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">151</span> → <span class="cddto">249</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2791</span> → <span class="cddto">2832</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1369</span> → <span class="cddto">2556</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2320</span> → <span class="cddto">2333</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2169</span> → <span class="cddto">2353</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1463</span> → <span class="cddto">1586</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201386.2">NM_201386.2</a> → <a href="/protein/NP_958788.2">NP_958788.2</a> plectin isoform 1e</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (3), also known as 1e, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1e) contains a distinct N-terminus compared to isoform 1c.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC110211, AY480035">AC110211, AY480035</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS49648.1">CCDS49648.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S392" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S392</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000071765.6" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000071765.6</a>, <a href="http://www.ensembl.org/id/ENSMUST00000071869.12" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000071869.12</a></dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958788.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">497</span> → <span class="cddto">591</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3068</span> → <span class="cddto">3104</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">21</span> → <span class="cddto">123</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">593</span> → <span class="cddto">771</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">138</span> → <span class="cddto">236</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2778</span> → <span class="cddto">2819</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1356</span> → <span class="cddto">2543</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2307</span> → <span class="cddto">2320</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2156</span> → <span class="cddto">2340</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1450</span> → <span class="cddto">1573</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201387.3">NM_201387.3</a> → <a href="/protein/NP_958789.3">NP_958789.3</a> plectin isoform 1hij</p>
|
||
<p>
|
||
<a href="/ipg/NP_958789.3/" ref="ncbi_uid=18810">See identical proteins and their annotated locations for NP_958789.3</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (4), also known as 1i, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5, 9 and 12 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC110211, AY480036">AC110211, AY480036</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS37117.2">CCDS37117.2</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/E9Q3W4" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">E9Q3W4</a>, <a href="https://www.uniprot.org/uniprot/Q6S390" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S390</a></dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000129543.2" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000129543.2</a>, <a href="http://www.ensembl.org/id/ENSMUST00000171562.8" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000171562.8</a></dd>
|
||
<dt class="clear"> Conserved Domains (9) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958789.3">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">362</span> → <span class="cddto">456</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2933</span> → <span class="cddto">2969</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">458</span> → <span class="cddto">636</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">101</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2643</span> → <span class="cddto">2684</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1221</span> → <span class="cddto">2408</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2172</span> → <span class="cddto">2185</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2088</span> → <span class="cddto">2205</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1315</span> → <span class="cddto">1438</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201388.2">NM_201388.2</a> → <a href="/protein/NP_958790.2">NP_958790.2</a> plectin isoform 1hij</p>
|
||
<p>
|
||
<a href="/ipg/NP_958790.2/" ref="ncbi_uid=18810">See identical proteins and their annotated locations for NP_958790.2</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (5), also known as 1j, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5, 9 and 12 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC110211, AY480037">AC110211, AY480037</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS37117.2">CCDS37117.2</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/E9Q3W4" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">E9Q3W4</a>, <a href="https://www.uniprot.org/uniprot/Q6S390" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S390</a></dd>
|
||
<dt class="clear"> Conserved Domains (9) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958790.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">362</span> → <span class="cddto">456</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2933</span> → <span class="cddto">2969</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">458</span> → <span class="cddto">636</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">101</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2643</span> → <span class="cddto">2684</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1221</span> → <span class="cddto">2408</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2172</span> → <span class="cddto">2185</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2088</span> → <span class="cddto">2205</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1315</span> → <span class="cddto">1438</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201389.2">NM_201389.2</a> → <a href="/protein/NP_958791.2">NP_958791.2</a> plectin isoform 1</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (6) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1) contains a distinct N-terminus compared to isoform 1c.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AI464512, AY480038, CN669707">AI464512, AY480038, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS37114.1">CCDS37114.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S388" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S388</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000075772.6" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000075772.6</a>, <a href="http://www.ensembl.org/id/ENSMUST00000076442.12" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000076442.12</a></dd>
|
||
<dt class="clear"> Conserved Domains (12) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958791.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">662</span> → <span class="cddto">756</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3233</span> → <span class="cddto">3269</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">186</span> → <span class="cddto">288</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">758</span> → <span class="cddto">936</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">303</span> → <span class="cddto">401</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2943</span> → <span class="cddto">2984</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1521</span> → <span class="cddto">2708</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=281497">pfam03501</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">7</span> → <span class="cddto">101</span></dt>
|
||
<dd class="clearfix"> S10_plectin; Plectin/S10 domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2472</span> → <span class="cddto">2485</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=295325">cl02488</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1866</span> → <span class="cddto">2041</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2321</span> → <span class="cddto">2505</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1615</span> → <span class="cddto">1738</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201390.2">NM_201390.2</a> → <a href="/protein/NP_958792.2">NP_958792.2</a> plectin isoform 1d</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (7), also known as 1d, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1d) contains a distinct N-terminus compared to isoform 1c.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AI464512, AY480039, CN669707">AI464512, AY480039, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS49646.1">CCDS49646.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S388" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S388</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000126068.2" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000126068.2</a>, <a href="http://www.ensembl.org/id/ENSMUST00000169108.8" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000169108.8</a></dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958792.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">487</span> → <span class="cddto">581</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3058</span> → <span class="cddto">3094</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">11</span> → <span class="cddto">113</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">583</span> → <span class="cddto">761</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">128</span> → <span class="cddto">226</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2768</span> → <span class="cddto">2809</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1346</span> → <span class="cddto">2533</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2297</span> → <span class="cddto">2310</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2213</span> → <span class="cddto">2330</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1440</span> → <span class="cddto">1563</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201391.2">NM_201391.2</a> → <a href="/protein/NP_958793.2">NP_958793.2</a> plectin isoform 1b</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (8), also known as 1b, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1b) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1b has been found to associate exclusively with mitochondria (PMID: 18541706, 14559777).</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AI464512, AY480040, CN669707">AI464512, AY480040, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS49644.1">CCDS49644.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S387" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S387</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000126526.2" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000126526.2</a>, <a href="http://www.ensembl.org/id/ENSMUST00000169714.8" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000169714.8</a></dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958793.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">519</span> → <span class="cddto">613</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3090</span> → <span class="cddto">3126</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">43</span> → <span class="cddto">145</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">615</span> → <span class="cddto">793</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">160</span> → <span class="cddto">258</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2800</span> → <span class="cddto">2841</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1378</span> → <span class="cddto">2565</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2329</span> → <span class="cddto">2342</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2178</span> → <span class="cddto">2362</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1472</span> → <span class="cddto">1595</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201392.2">NM_201392.2</a> → <a href="/protein/NP_958794.2">NP_958794.2</a> plectin isoform 1hij</p>
|
||
<p>
|
||
<a href="/ipg/NP_958794.2/" ref="ncbi_uid=18810">See identical proteins and their annotated locations for NP_958794.2</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (9), also known as 1h, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5, 9 and 12 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC110211, AY480041">AC110211, AY480041</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS37117.2">CCDS37117.2</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/E9Q3W4" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">E9Q3W4</a>, <a href="https://www.uniprot.org/uniprot/Q6S390" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S390</a></dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000127261.2" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000127261.2</a>, <a href="http://www.ensembl.org/id/ENSMUST00000169438.8" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000169438.8</a></dd>
|
||
<dt class="clear"> Conserved Domains (9) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958794.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">362</span> → <span class="cddto">456</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2933</span> → <span class="cddto">2969</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">458</span> → <span class="cddto">636</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">101</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2643</span> → <span class="cddto">2684</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1221</span> → <span class="cddto">2408</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2172</span> → <span class="cddto">2185</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2088</span> → <span class="cddto">2205</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1315</span> → <span class="cddto">1438</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201393.2">NM_201393.2</a> → <a href="/protein/NP_958795.2">NP_958795.2</a> plectin isoform 1g</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (10), also known as 1g, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1g) contains a distinct N-terminus compared to isoform 1c.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AI464512, AY480042, CN669707">AI464512, AY480042, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS37115.1">CCDS37115.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S385" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S385</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000072478.5" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000072478.5</a>, <a href="http://www.ensembl.org/id/ENSMUST00000072692.11" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000072692.11</a></dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958795.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">526</span> → <span class="cddto">620</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3097</span> → <span class="cddto">3133</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">50</span> → <span class="cddto">152</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">622</span> → <span class="cddto">800</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">167</span> → <span class="cddto">265</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2807</span> → <span class="cddto">2848</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1385</span> → <span class="cddto">2572</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2336</span> → <span class="cddto">2349</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2185</span> → <span class="cddto">2369</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1479</span> → <span class="cddto">1602</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_201394.2">NM_201394.2</a> → <a href="/protein/NP_958796.2">NP_958796.2</a> plectin isoform 1a</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (11), also known as 1a, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1a) contains a distinct N-terminus compared to isoform 1c.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AI464512, AY480043, CN669707">AI464512, AY480043, CN669707</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS37116.1">CCDS37116.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/Q6S388" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">Q6S388</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSMUSP00000023226.7" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUSP00000023226.7</a>, <a href="http://www.ensembl.org/id/ENSMUST00000023226.13" ref="itool=Gene_FullReport&PrId=5380&uid=18810&nlmid=&db=gene">ENSMUST00000023226.13</a></dd>
|
||
<dt class="clear"> Conserved Domains (10) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_958796.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197544">smart00150</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">519</span> → <span class="cddto">613</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=197605">smart00250</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3090</span> → <span class="cddto">3126</span></dt>
|
||
<dd class="clearfix"> PLEC; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=237981">cd00014</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">43</span> → <span class="cddto">145</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=238103">cd00176</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">615</span> → <span class="cddto">793</span></dt>
|
||
<dd class="clearfix"> SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=278723">pfam00307</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">160</span> → <span class="cddto">258</span></dt>
|
||
<dd class="clearfix"> CH; Calponin homology (CH) domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279071">pfam00681</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2800</span> → <span class="cddto">2841</span></dt>
|
||
<dd class="clearfix"> Plectin; Plectin repeat</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=279860">pfam01576</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1378</span> → <span class="cddto">2565</span></dt>
|
||
<dd class="clearfix"> Myosin_tail_1; Myosin tail</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=293879">cd16269</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2329</span> → <span class="cddto">2342</span></dt>
|
||
<dd class="clearfix"> GBP_C; coiled coil [structural motif]</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=303769">cl20817</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">2178</span> → <span class="cddto">2362</span></dt>
|
||
<dd class="clearfix"> GBP_C; Guanylate-binding protein, C-terminal domain</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=304375">cl21478</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">1472</span> → <span class="cddto">1595</span></dt>
|
||
<dd class="clearfix"> ATP-synt_B; ATP synthase B/B' CF(0)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
|
||
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following sections contain reference sequences that belong to a
|
||
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
|
||
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
|
||
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
|
||
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
|
||
assemblies. Model RNAs and proteins are also reported here.</p>
|
||
<h3 id="refseq-sequencedescription-p43781360">Reference GRCm39 C57BL/6J</h3>
|
||
<h4 id="genomic-p43781360">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_000081.7 Reference GRCm39 C57BL/6J</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>76055174..76115578 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_000081.7?from=76055174&to=76115578&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=18810&link_uid=NC_000081.7?from=76055174&to=76115578&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NC_000081.7?from=76055174&to=76115578&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=18810&link_uid=NC_000081.7?from=76055174&to=76115578&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NC_000081.7?from=76046112&to=76124638&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=18810&link_uid=NC_000081.7?from=76046112&to=76124638&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler">
|
||
<a class="jig-ncbitoggler">Suppressed Reference Sequence(s)</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following Reference Sequences have been suppressed. <a href="#expl-suppressed-desc" id="expl-suppressed">Explain</a></p>
|
||
<p id="expl-suppressed-desc" style="display:none">These RefSeqs were suppressed for the
|
||
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
|
||
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
|
||
their accession.version below.</p>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/254675112">NR_028117.1</a>: Suppressed sequence</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>NR_028117.1: This RefSeq was permanently suppressed because there is support for the transcript as protein coding.</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-related-sequences">
|
||
<section class="rprt-section-header" id="related-sequences">
|
||
<h2 id="header-related-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Related sequences</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/18810/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th colspan="2" id="rs-nucleo">Nucleotide</th>
|
||
<th rowspan="2" id="rs-protein">Protein</th>
|
||
<th class="nucleoTblTh" rowspan="2" id="rs-strain">Strain</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-heading">Heading</th>
|
||
<th id="rs-heading-acc">Accession and Version</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
|
||
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-genepept">GenPept Link</th>
|
||
<th id="rs-uniprot">UniProtKB Link</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="rs-prot-acc">Q9QXS1.3</td>
|
||
<td headers="rs-link rs-genepept">
|
||
<a href="/protein/613504943" ref="ordinalpos=1&ncbi_uid=18810&link_uid=613504943">GenPept</a>
|
||
</td>
|
||
<td>
|
||
<a href="https://www.uniprot.org/uniprot/Q9QXS1">UniProtKB/Swiss-Prot:Q9QXS1</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-additional-links">
|
||
|
||
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
|
||
|
||
<h3 class="withnote" id="genelinkout">
|
||
<a class="jig-ncbitoggler">Gene LinkOut</a>
|
||
</h3><div>
|
||
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
|
||
<div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Chemical Information</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/mouse?proteins=18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7911">
|
||
<span>Interologous Interaction Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>MilliporeSigma</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/PLEC?lang=en&region=US" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=9978">
|
||
<span>Plec products</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Molecular Biology Databases</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Bgee database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bgee.org/gene/ENSMUSG00000022565" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=10418">
|
||
<span>Plec gene expression</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGPS</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://biogps.org/gene/18810/" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=5059">
|
||
<span>BioGPS</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=10164">
|
||
<span>BioGRID CRISPR Screen Phenotypes (5 hits/97 screens)</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=mmEpdNew&format=genome&entry=Plec_1" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=9624">
|
||
<span>Plec_1</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://glygen.org/protein/Q9QXS1" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=10227">
|
||
<span>GlyGen glycoinformatics resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>Ingenuity Pathways Analysis</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&p1=Entrez&p2=GV&s=&ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D18810%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=5628">
|
||
<span>Ingenuity Pathways Analysis</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InnateDB</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=153069" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7894">
|
||
<span>InnateDB</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?mmu:18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=5174">
|
||
<span>Kyoto Encyclopedia of Genes and Genomes</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/MOUSE17362/" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/MOUSE17366/" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/MOUSE17357/" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.orthodb.org/?ncbi=18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=8178">
|
||
<span>Orthologs</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7987">
|
||
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Research Materials</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://addgene.org//browse/gene/18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=5304">
|
||
<span>Get Plasmids - Addgene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>ExactAntigen/Labome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/review/gene/mouse/Plec-antibody.html" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagent review</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/gene/mouse/Plec-antibody.html" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagents</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genscript.com/gene/18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=8012">
|
||
<span>GenScript latest version of gene cDNA ORF Clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=7&field=5&key=18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order full-length ORF clone</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=12&field=5&key=18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order shRNA clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=10090&prt=22&field=5&key=18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order promoter clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>OriGene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=Plec1" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order Plec1 cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=PLEC" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order PLEC cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Tools</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>GeneMANIA</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://genemania.org/link?o=10090&g=18810" ref="itool=Gene_FullReport&uid=18810&nlmid=&db=gene&log$=linkoutlink&PrId=7529">
|
||
<span>GeneMANIA</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="urls-in-genombrowser" style="display:none">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div><input type="hidden" class="section_status_input" name="status_checked" id="status_checked" value="" /><input type="hidden" class="section_status_input" name="status_open" id="status_open" value="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_exist" id="status_exist" value="summary,context,region,expression,bibliography,variation,,interactions,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_closed" id="status_closed" value="" /><meta name="status_checked" content="" class="meta_section_status" /><meta name="status_open" content="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_exist" content="summary,context,region,expression,bibliography,variation,,interactions,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_closed" content="" class="meta_section_status" /><script type="text/javascript">
|
||
|
||
var section_status_meta = {
|
||
'status_checked': '',
|
||
'status_open': 'summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_exist': 'summary,context,region,expression,bibliography,variation,,interactions,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_closed': ''
|
||
};
|
||
|
||
|
||
/*
|
||
for (var o in section_status_meta) {
|
||
var meta=document.createElement('meta');
|
||
meta.name = o;
|
||
meta.content = section_status_meta[o];
|
||
var attr = document.createAttribute('data-ignore-limit');
|
||
attr.value = 'true';
|
||
meta.setAttributeNode(attr);
|
||
document.getElementsByTagName('head')[0].appendChild(meta);
|
||
}
|
||
*/
|
||
|
||
|
||
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
|
||
// data looks like {jsevent: "click", "link_id": "foo", ...}
|
||
// evtObj is the JS event object
|
||
// type is either "stat" (for applog) or "ga"
|
||
var extraData = {};
|
||
if (type == "stat") {
|
||
for (var o in section_status_meta) {
|
||
extraData[o] = section_status_meta[o];
|
||
}
|
||
|
||
return extraData;
|
||
|
||
}
|
||
}
|
||
|
||
|
||
</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last" id="sidebar_tabular">
|
||
<!-- sidebar close/hide button-->
|
||
<div class="ui-helper-clearfix">
|
||
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar >></span></a>
|
||
</div>
|
||
<!-- end sidebar close/hide button-->
|
||
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div id="gene-sidebar">
|
||
<div>
|
||
<div class="portlet brieflink dis-table-of-contents">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Table of contents</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li class="">
|
||
<a href="#summary">Summary</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-context">Genomic context</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#gene-expression">Expression</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#bibliography">Bibliography</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#variation">Variation</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#pathways">Pathways from PubChem</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#interactions">Interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-gene-info">General gene information</a>
|
||
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-protein-info">General protein information</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#related-sequences">Related sequences</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#additional-links">Additional links</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Genome Browsers</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="#">Loading...</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-related-info brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&from_uid=18810" ref="log$=recordlinks">3D structures</a>
|
||
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&from_uid=18810" ref="log$=recordlinks">BioAssay by Target (List)</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&from_uid=18810" ref="log$=recordlinks">BioAssay, by Gene target</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&from_uid=18810" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&from_uid=18810" ref="log$=recordlinks">BioProjects</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&from_uid=18810" ref="log$=recordlinks">BioSystems</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&DATA=18810" ref="log$=recordlinks">CCDS</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&from_uid=18810" ref="log$=recordlinks">Conserved Domains</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&from_uid=18810" ref="log$=recordlinks">Full text in PMC</a>
|
||
<div class="brieflinkpop offscreen_noflow">PMC links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&from_uid=18810" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&from_uid=18810" ref="log$=recordlinks">Gene neighbors</a>
|
||
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&from_uid=18810" ref="log$=recordlinks">Genome</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&from_uid=18810" ref="log$=recordlinks">GEO Profiles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&from_uid=18810" ref="log$=recordlinks">HomoloGene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&from_uid=18810" ref="log$=recordlinks">Nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&from_uid=18810" ref="log$=recordlinks">Probe</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&from_uid=18810" ref="log$=recordlinks">Protein</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&from_uid=18810" ref="log$=recordlinks">PubChem Compound</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&from_uid=18810" ref="log$=recordlinks">PubChem Substance</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&from_uid=18810" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&from_uid=18810" ref="log$=recordlinks">PubMed (GeneRIF)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&from_uid=18810" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&from_uid=18810" ref="log$=recordlinks">RefSeq Proteins</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&from_uid=18810" ref="log$=recordlinks">RefSeq RNAs</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&from_uid=18810" ref="log$=recordlinks">Taxonomy</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-links-to-other-res brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Links to other resources</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="http://www.informatics.jax.org/marker/MGI:1277961">MGI</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.ensembl.org/id/ENSMUSG00000022565">Ensembl</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.alliancegenome.org/gene/MGI:1277961">AllianceGenome</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.informatics.jax.org/gxd/marker/MGI:1277961">Gene Expression Database (GXD) at MGI</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=NM_001163540">UCSC</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.genome.jp/dbget-bin/www_bget?mmu:18810">KEGG</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-general-info">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>General information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3840">FAQ</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3841/">Help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3842/">My NCBI help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK21085/">NCBI Handbook</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/statistics/">Statistics</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-related-sites">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related sites</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-feedback">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Feedback</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
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<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&deptID=28049">Contact Help Desk</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=18810&symbol=Plec">Submit Correction</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/submit-generif?geneId=18810&sym=Plec&name=plectin&org=Mus musculus">Submit GeneRIF</a>
|
||
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|
||
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|
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<div class="portlet_content">
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<ul>
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<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
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</div>
|
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<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
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Clear
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
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Turn Off
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Turn On
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|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9ccb884f3725e59bbc55f">Plec plectin [Mus musculus]</a>
|
||
<div class="ralinkpop offscreen_noflow">Plec plectin [Mus musculus]<div class="brieflinkpopdesc">Gene ID:18810</div></div>
|
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<div class="tertiary">Gene</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9ccb1f4a390645ebd9cae">RecName: Full=Cellular tumor antigen p53; AltName: Full=Antigen NY-CO-13; AltNam...</a>
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<div class="ralinkpop offscreen_noflow">RecName: Full=Cellular tumor antigen p53; AltName: Full=Antigen NY-CO-13; AltName: Full=Phosphoprotein p53; AltName: Full=Tumor suppressor p53<div class="brieflinkpopdesc">gi|269849759|sp|P04637.4|P53_HUMAN</div></div>
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<div class="tertiary">Protein</div>
|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9cc2484f3725e59b7d8af">reverse transcriptase [Human immunodeficiency virus 1]</a>
|
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<div class="ralinkpop offscreen_noflow">reverse transcriptase [Human immunodeficiency virus 1]<div class="brieflinkpopdesc">gi|25121907|ref|NP_705927.1|</div></div>
|
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<div class="tertiary">Protein</div>
|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9cc14b15b832ebc8c7de4">vif [Human immunodeficiency virus 1]</a>
|
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<div class="ralinkpop offscreen_noflow">vif [Human immunodeficiency virus 1]<div class="brieflinkpopdesc">Gene ID:155459</div></div>
|
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<div class="tertiary">Gene</div>
|
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</li>
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<li class="ra_rcd ralinkpopper two_line">
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c9cc12a68b6b5afcf22281">Vif [Human immunodeficiency virus 1]</a>
|
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<div class="ralinkpop offscreen_noflow">Vif [Human immunodeficiency virus 1]<div class="brieflinkpopdesc">gi|9629361|ref|NP_057851.1|</div></div>
|
||
<div class="tertiary">Protein</div>
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||
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