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<title>9G7I: Structure of carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) in complex with acetyl-Coenyzme A from Clostridium autoethanogenum</title>
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<section data-section="infor" id="structure-infor-section"><h1 class="structure-title" data-mmdbid="259354" data-pdbid="9G7I" id="structure-title"><a class="link title-pdbid" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=9G7I" style="font-weight:600;margin:0;">9G7I: </a><span>Structure of carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) in complex with acetyl-Coenyzme A from Clostridium autoethanogenum</span></h1>
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<td><a id="pdb_id_link" class="link" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=9G7I" title="PDB ID">9G7I</a><a id="download-pdb-file" class="__button" tabindex="-1" href="https://files.rcsb.org/download/9G7I.pdb" title="Download PDB file" download="9G7I.pdb">Download</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvStructureViewDataSetPDBdataset" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">PDB Deposition Date: </td>
<td><span id="depositionterm" style="padding-left: 0.2em;">2024/7/21<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDeposited" title="-click to see help"></a></span></td>
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<td class="text" nowrap><span id="mmdb_updated" style="padding-left:0.2em">2025/02</span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvUpdatedInMMDB" title="-click to see help"></a></td>
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<td class="TEXT" nowrap><div id="expmethod"><span title="x-ray diffraction" class="info-item">x-ray diffraction</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvExperimentalMethod" title="-click to see help"></a></div></td>
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<td class="TEXT" id="resolution" nowrap>2.93&nbsp; &#197;<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#SearchFieldResolution" title="-click to see help"></a></td>
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<td class="text"><div id="taxonomy"><a id="taxword" class="link" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=1341692" title="Clostridium autoethanogenum DSM 10061">Clostridium autoethanogenum DSM 10061</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvTaxonomy" title="-click to see help"></a></div></td>
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<div align="center" id="annotblock" style="margin-top:0.8em;"><div class="formbox" id="authormethod"><div id="bublock0"><div class="biotext" id="bublock0_unit_name">Biological Unit for 9G7I: tetrameric; determined by author and by software (PISA)<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvBiologicalUnit" title="-click to see help"></a></div>
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<section class="content_block" data-section="table"><table border="1" class="bucontent"><caption class="butbl_caption">Molecular Components in 9G7I<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents" title="-click to see help"></a></caption>
<thead><tr><th>Label</th>
<th>Count</th>
<th>Molecule</th>
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<tbody data-bun="1" data-type="protein" id="unit1_protein_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Proteins (4 molecules)</div></td></tr>
<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-1" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/9G7I_A" id="mol-legend-1-1" class="protein-molecule-label-1" data-gi="2908631847" data-molid="1" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">A</div></a><a href="//www.ncbi.nlm.nih.gov/protein/9G7I_D" id="mol-legend-1-4" class="protein-molecule-label-1" data-gi="2908631850" data-molid="4" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">D</div></a></div></td>
<td>2</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Co-methylating Acetyl-coa Synthase">Co-methylating Acetyl-coa Synthase</div>
<div class="annot-img-block" data-bun="1" data-gmolid="1" data-molids="1,4" id="molgraph-p-1-1"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-2" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/9G7I_B" id="mol-legend-1-2" class="protein-molecule-label-1" data-gi="2908631848" data-molid="2" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">B</div></a><a href="//www.ncbi.nlm.nih.gov/protein/9G7I_C" id="mol-legend-1-3" class="protein-molecule-label-1" data-gi="2908631849" data-molid="3" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">C</div></a></div></td>
<td>2</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Carbon Monoxide Dehydrogenase">Carbon Monoxide Dehydrogenase</div>
<div class="annot-img-block" data-bun="1" data-gmolid="2" data-molids="2,3" id="molgraph-p-1-2"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
</tbody>
<tbody data-bun="1" data-type="chemical" id="unit1_chemical_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Chemicals and Non-standard biopolymers (75 molecules)</div></td></tr>
<tr><td data-row="0"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-1" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="5,26,53,54,67" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916377">1</a></span></div></td>
<td><div class="chem-label">5</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916377"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916377" title="IRON/SULFUR CLUSTER">IRON/SULFUR CLUSTER</a></span><span class="chem-image-holder" title="IRON/SULFUR CLUSTER"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916377"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916377" alt="IRON/SULFUR CLUSTER"></a></span></div></td>
</tr>
<tr><td data-row="1"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-2" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="6,7,68,69" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916378">2</a></span></div></td>
<td><div class="chem-label">4</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916378"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916378" title="NICKEL (II) ION">NICKEL (II) ION</a></span><span class="chem-image-holder" title="NICKEL (II) ION"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916378"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916378" alt="NICKEL (II) ION"></a></span></div></td>
</tr>
<tr><td data-row="2"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-3" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="8,10,19,20,21,22,23,24,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,55,61,62,63,64,65,66,76,77,78,79" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916380">3</a></span></div></td>
<td><div class="chem-label">34</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916380"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916380" title="1,2-ETHANEDIOL">1,2-ETHANEDIOL</a></span><span class="chem-image-holder" title="1,2-ETHANEDIOL"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916380"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916380" alt="1,2-ETHANEDIOL"></a></span></div></td>
</tr>
<tr><td data-row="3"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-4" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="9" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916381">4</a></span></div></td>
<td><div class="chem-label">1</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916381"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916381" title="2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL">2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL</a></span><span class="chem-image-holder" title="2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916381"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916381" alt="2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL"></a></span></div></td>
</tr>
<tr><td data-row="4"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-5" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="11,25,28,30,31,72" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916382">5</a></span></div></td>
<td><div class="chem-label">6</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916382"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916382" title="GLYCEROL">GLYCEROL</a></span><span class="chem-image-holder" title="GLYCEROL"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916382"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916382" alt="GLYCEROL"></a></span></div></td>
</tr>
<tr><td data-row="5"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-6" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="12,27,70" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916383">6</a></span></div></td>
<td><div class="chem-label">3</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916383"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916383" title="DI(HYDROXYETHYL)ETHER">DI(HYDROXYETHYL)ETHER</a></span><span class="chem-image-holder" title="DI(HYDROXYETHYL)ETHER"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916383"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916383" alt="DI(HYDROXYETHYL)ETHER"></a></span></div></td>
</tr>
<tr><td data-row="6"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-7" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="13,14,15,16,32,57,58,59,74,75" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916384">7</a></span></div></td>
<td><div class="chem-label">10</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916384"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916384" title="CALCIUM ION">CALCIUM ION</a></span><span class="chem-image-holder" title="CALCIUM ION"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916384"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916384" alt="CALCIUM ION"></a></span></div></td>
</tr>
<tr><td data-row="7"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-8" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="17,18,33,34,35,36,37,60" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916385">8</a></span></div></td>
<td><div class="chem-label">8</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916385"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916385" title="CHLORIDE ION">CHLORIDE ION</a></span><span class="chem-image-holder" title="CHLORIDE ION"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916385"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916385" alt="CHLORIDE ION"></a></span></div></td>
</tr>
<tr><td data-row="8"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-9" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="29,56" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916386">9</a></span></div></td>
<td><div class="chem-label">2</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916386"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916386" title="FE(4)-NI(1)-S(4) CLUSTER">FE(4)-NI(1)-S(4) CLUSTER</a></span><span class="chem-image-holder" title="FE(4)-NI(1)-S(4) CLUSTER"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916386"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916386" alt="FE(4)-NI(1)-S(4) CLUSTER"></a></span></div></td>
</tr>
<tr><td data-row="9"><div class="chem-label-box"><span class="chemical-molecule-label large-chem-label" id="mol-chem-legend-1-10" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="71" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916387" style="font-size:9px;">10</a></span></div></td>
<td><div class="chem-label">1</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916387"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916387" title="ACETYL COENZYME *A">ACETYL COENZYME *A</a></span><span class="chem-image-holder" title="ACETYL COENZYME *A"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916387"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916387" alt="ACETYL COENZYME *A"></a></span></div></td>
</tr>
<tr><td data-row="10"><div class="chem-label-box"><span class="chemical-molecule-label large-chem-label" id="mol-chem-legend-1-11" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="73" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916388" style="font-size:9px;">11</a></span></div></td>
<td><div class="chem-label">1</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505916388"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916388" title="2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL">2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL</a></span><span class="chem-image-holder" title="2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505916388"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505916388" alt="2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL"></a></span></div></td>
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<div style="margin:0.5em 1em;text-align:left; font-size:85%;">&#42; Click molecule labels to explore molecular sequence information.<br/></div>
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<div align="left" class="citing"><hr width="85%"/><div style="font-weight:bold">Citing MMDB</div><div class="citref" style="padding:0.2em;"><img style="border:0;text-align:left;height:15px;width:15px;margin-right:0.2em" src="//pubchem.ncbi.nlm.nih.gov/images/PubMed.gif"> <span style="color:#444"> Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. </span> <cite><a class="link" href="//www.ncbi.nlm.nih.gov/pubmed/24319143">"<span style="font-style:italic;"> MMDB and VAST+: tracking structural similarities between macromolecular complexes. <b style="font-size:90%">Nucleic Acids Res. 2014 Jan; 42(Database issue)</b>:D297-303</span></a></cite></div></div>
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