231 lines
31 KiB
Text
231 lines
31 KiB
Text
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<title>7KZT: Structure of the human fanconi anaemia Core-UBE2T-ID-DNA complex in intermediate state</title>
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<meta name="keywords" content="DNA (22-MER), E3 ubiquitin-protein ligase FANCL, Fanconi anemia core complex-associated protein 100, Fanconi anemia core complex-associated protein 20, Fanconi anemia group A protein, Fanconi anemia group B protein, Fanconi anemia group C protein, Fanconi anemia group D2 protein, Fanconi anemia group E protein, Fanconi anemia group F protein, Fanconi anemia group G protein, Fanconi anemia, complementation group I, Ubiquitin-conjugating enzyme E2 T, ZINC ION, MMDB, Protein structure, protein interaction">
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<table cellspacing="0" id="mmdb_logo_links" cellpadding="0" width="100%"><tr><td><a class="ncbi_home_logo" href="/" alt="NBI HOME Logo">NCBI</a><div class="NLMLogo">National Center for<br/>Biotechnology Information</div></td><td class="titletext" align="left"><!--a href="/Structure/MMDB/mmdb.shtml"--><img border=0 src="/Structure/MMDB/strbanner.jpg" alt="7KZT - NCBI MMDB Logo"><!--/a--></td><td style="padding-bottom:1em;vertical-align:bottom"><form id="mmdbsearch" method="get" name="mmdbsearch" action="/Structure/pdb/" style="margin:0;padding:0;vertical-align: bottom;"><div class="mmdb-search-holder" style="height:100%;line-height:100%"><input accesskey="S" id="mmdb-search-box" type="search" name="uid" placeholder="Enter PDB ID or MMDB ID" value = "" aria-describedby="mmdb-search-uid" title="Enter PDB ID or MMDB ID"><button id="mmdb-search-button" class="__button mmdb-search-button" style="height:100%;line-height:100%;margin-right:-3px;" type="submit">Search</button></div></form></td></tr></table>
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<!-- StructureInfo start -->
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<section data-section="infor" id="structure-infor-section"><h1 class="structure-title" data-mmdbid="199701" data-pdbid="7KZT" id="structure-title"><a class="link title-pdbid" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=7KZT" style="font-weight:600;margin:0;">7KZT: </a><span>Structure of the human fanconi anaemia Core-UBE2T-ID-DNA complex in intermediate state</span></h1>
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<div class="floatClear" id="infor-detail"><div class="reference_section" data-pmids="33686268" id="reference-section"></div>
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<div class="property_section"><form action="/Structure/mmdb/mmdbsrv.cgi" method="post" id="reloadform" name="reloadform" style="margin:0;padding:0"><input type="hidden" name="uid" value="199701"/></form><table border="0" cellpadding="4" cellspacing="4"><tr><td class="H4 pdbid-download">PDB ID: </td>
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<td><a id="pdb_id_link" class="link" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=7KZT" title="PDB ID">7KZT</a><a id="download-pdb-file" class="__button" tabindex="-1" href="https://files.rcsb.org/download/7KZT.pdb" title="Download PDB file" download="7KZT.pdb">Download</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvStructureViewDataSetPDBdataset" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">MMDB ID: </td>
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<td style="font-weight:bold"><span class="info-item">199701</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvRecordIdentifiers" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">PDB Deposition Date: </td>
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<td><span id="depositionterm" style="padding-left: 0.2em;">2020/12/10<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDeposited" title="-click to see help"></a></span></td>
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</tr>
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<tr><td class="H4 property-name">Updated in MMDB: </td>
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<td class="text" nowrap><span id="mmdb_updated" style="padding-left:0.2em">2024/10</span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvUpdatedInMMDB" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">Experimental Method: </td>
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<td class="TEXT" nowrap><div id="expmethod"><span title="electron microscopy" class="info-item">electron microscopy</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvExperimentalMethod" title="-click to see help"></a></div></td>
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</tr>
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<tr><td class="H4 property-name">Resolution: </td>
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<td class="TEXT" id="resolution" nowrap>4.2 Å<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#SearchFieldResolution" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">Source Organism: </td>
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<td class="text"><div id="taxonomy"><div id="taxonomyterm"><span id="multitaxon" style="display:inline-block"><span id="taxword" title="synthetic construct">synthetic construct</span><span arr="down" class="taxdrop_arrow">▼</span></span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvTaxonomy" title="-click to see help"></a></div>
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<div class="menupop" id="taxonomycontent"><table cellpadding="0" cellspacing="0" width="300"><tr><th width="50%">Taxonomy</th>
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<th width="50%">Molecule</th>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=32630" style="text-decoration:underline;">synthetic construct</a></td>
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<td>Y, Z</td>
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</tr>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=9606" style="text-decoration:underline;">Homo sapiens</a></td>
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<td>A, B, C, E, F, G, H, L, O, P, Q, S, <br/>W, M, X, U, V</td>
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</tr>
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</table></div>
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</div></td>
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</tr>
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<tr><td class="H4 property-name">Similar Structures: </td>
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<td><div id="vast-button-holder" style="width:100%;overflow:hidden;"><button class="__button" id="vast_button" type="submit">VAST+</button>
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<a class="help-img" href="/Structure/vastplus/docs/vastplus_help.html" title="-click to see help"></a></div></td>
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<tr><td colspan="2" style="text-align: center"><button class="__button" id="download_sequence" type="submit">Download sequence data</button>
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<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDownaloadSequenceMMDB" title="-click to see help"></a></td></tr>
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</table>
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</div>
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</section>
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<!-- end of StructureInfo -->
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<!-- start annotations -->
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<div align="center" id="annotblock" style="margin-top:0.8em;"><div class="formbox" id="authormethod"><div id="bublock0"><div class="biotext" id="bublock0_unit_name">Biological Unit for 7KZT: 19-meric; determined by author<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvBiologicalUnit" title="-click to see help"></a></div>
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<style>.unitschema-1{
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background-image:url("/Structure/mmdb/mmdbimage.fcgi?uid=199701&type=2&unm=1");
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}</style><section class="graph-section" data-section="graph" id="biounit-section-1"></section>
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<section class="content_block" data-section="table"><table border="1" class="bucontent"><caption class="butbl_caption">Molecular Components in 7KZT<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents" title="-click to see help"></a></caption>
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<thead><tr><th>Label</th>
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<th>Count</th>
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<th>Molecule</th>
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</tr></thead>
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<tbody data-bun="1" data-type="protein" id="unit1_protein_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Proteins (17 molecules)</div></td></tr>
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<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-1" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_A" id="mol-legend-1-1" class="protein-molecule-label-1" data-gi="2003953602" data-molid="1" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">A</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_S" id="mol-legend-1-12" class="protein-molecule-label-1" data-gi="2003953613" data-molid="12" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">S</div></a></div></td>
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<td>2</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group a Protein">Fanconi Anemia Group a Protein</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="1" data-molids="1,12" id="molgraph-p-1-1"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-2" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_B" id="mol-legend-1-2" class="protein-molecule-label-1" data-gi="2003953603" data-molid="2" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">B</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_O" id="mol-legend-1-9" class="protein-molecule-label-1" data-gi="2003953610" data-molid="9" style="color:#000000;background-color:#00FFFF" title="-Select icon for molecule information"><div class="protein-table-chain-label">O</div></a></div></td>
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<td>2</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group B Protein">Fanconi Anemia Group B Protein</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="2" data-molids="2,9" id="molgraph-p-1-2"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="2"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-3" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_C" id="mol-legend-1-3" class="protein-molecule-label-1" data-gi="2003953604" data-molid="3" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">C</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group C Protein">Fanconi Anemia Group C Protein</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="3" data-molids="3" id="molgraph-p-1-3"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="3"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-4" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_E" id="mol-legend-1-4" class="protein-molecule-label-1" data-gi="2003953605" data-molid="4" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">E</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group E Protein">Fanconi Anemia Group E Protein</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="4" data-molids="4" id="molgraph-p-1-4"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="4"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-5" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_F" id="mol-legend-1-5" class="protein-molecule-label-1" data-gi="2003953606" data-molid="5" style="color:#000000;background-color:#CCCCCC" title="-Select icon for molecule information"><div class="protein-table-chain-label">F</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group F Protein">Fanconi Anemia Group F Protein</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="5" data-molids="5" id="molgraph-p-1-5"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="5"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-6" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_G" id="mol-legend-1-6" class="protein-molecule-label-1" data-gi="2003953607" data-molid="6" style="color:#000000;background-color:#FF9900" title="-Select icon for molecule information"><div class="protein-table-chain-label">G</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_H" id="mol-legend-1-7" class="protein-molecule-label-1" data-gi="2003953608" data-molid="7" style="color:#000000;background-color:#FF6666" title="-Select icon for molecule information"><div class="protein-table-chain-label">H</div></a></div></td>
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<td>2</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group G Protein">Fanconi Anemia Group G Protein</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="6" data-molids="6,7" id="molgraph-p-1-6"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="6"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-7" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_L" id="mol-legend-1-8" class="protein-molecule-label-1" data-gi="2003953609" data-molid="8" style="color:#000000;background-color:#00FF00" title="-Select icon for molecule information"><div class="protein-table-chain-label">L</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_M" id="mol-legend-1-14" class="protein-molecule-label-1" data-gi="2003953615" data-molid="14" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">M</div></a></div></td>
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<td>2</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="E3 Ubiquitin-protein Ligase Fancl">E3 Ubiquitin-protein Ligase Fancl</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="8" data-molids="8,14" id="molgraph-p-1-8"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="7"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-8" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_P" id="mol-legend-1-10" class="protein-molecule-label-1" data-gi="2003953611" data-molid="10" style="color:#000000;background-color:#FFFF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">P</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_Q" id="mol-legend-1-11" class="protein-molecule-label-1" data-gi="2003953612" data-molid="11" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">Q</div></a></div></td>
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<td>2</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Core Complex-associated Protein 100">Fanconi Anemia Core Complex-associated Protein 100</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="10" data-molids="10,11" id="molgraph-p-1-10"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="8"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-9" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_W" id="mol-legend-1-13" class="protein-molecule-label-1" data-gi="2003953614" data-molid="13" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">W</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Core Complex-associated Protein 20">Fanconi Anemia Core Complex-associated Protein 20</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="13" data-molids="13" id="molgraph-p-1-13"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="9"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-10" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_X" id="mol-legend-1-15" class="protein-molecule-label-1" data-gi="2003953616" data-molid="15" style="color:#000000;background-color:#CCCCCC" title="-Select icon for molecule information"><div class="protein-table-chain-label">X</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Ubiquitin-conjugating Enzyme E2 T">Ubiquitin-conjugating Enzyme E2 T</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="15" data-molids="15" id="molgraph-p-1-15"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="10"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-11" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_U" id="mol-legend-1-16" class="protein-molecule-label-1" data-gi="2003953617" data-molid="16" style="color:#000000;background-color:#FF9900" title="-Select icon for molecule information"><div class="protein-table-chain-label">U</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia, Complementation Group I">Fanconi Anemia, Complementation Group I</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="16" data-molids="16" id="molgraph-p-1-16"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="11"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-12" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZT_V" id="mol-legend-1-17" class="protein-molecule-label-1" data-gi="2003953618" data-molid="17" style="color:#000000;background-color:#FF6666" title="-Select icon for molecule information"><div class="protein-table-chain-label">V</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group D2 Protein">Fanconi Anemia Group D2 Protein</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="17" data-molids="17" id="molgraph-p-1-17"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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</tbody>
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<tbody data-bun="1" data-type="nucleotide" id="unit1_nucleotide_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Nucleotides(2 molecules)</div></td></tr>
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<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-13" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/nuccore/7KZT_Y" id="mol-legend-1-18" class="drna-molecule-label" data-gi="2003953619" data-molid="18" style="color:#000000;background-color:#00FF00" title="-Select icon for molecule information"><div class="protein-table-chain-label">Y</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="DNA (22-mer)">DNA (22-mer)</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="18" data-molids="18" id="molgraph-n-1-18"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-14" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/nuccore/7KZT_Z" id="mol-legend-1-19" class="drna-molecule-label" data-gi="2003953620" data-molid="19" style="color:#000000;background-color:#00FFFF" title="-Select icon for molecule information"><div class="protein-table-chain-label">Z</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="DNA (22-mer)">DNA (22-mer)</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="19" data-molids="19" id="molgraph-n-1-19"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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</tbody>
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<tbody data-bun="1" data-type="chemical" id="unit1_chemical_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Chemicals and Non-standard biopolymers (5 molecules)</div></td></tr>
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<tr><td data-row="0"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-1" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="20,21,22,23,24" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=440790103">1</a></span></div></td>
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<td><div class="chem-label">5</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="440790103"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=440790103" title="ZINC ION">ZINC ION</a></span><span class="chem-image-holder" title="ZINC ION"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=440790103"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=440790103" alt="ZINC ION"></a></span></div></td>
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</tr>
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</tbody>
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</table>
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<div style="margin:0.5em 1em;text-align:left; font-size:85%;">* Click molecule labels to explore molecular sequence information.<br/></div>
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</section>
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</div></div></div>
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<!-- end annotations -->
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</td></tr>
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</table>
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<!-- Start of citation -->
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<div align="left" class="citing"><hr width="85%"/><div style="font-weight:bold">Citing MMDB</div><div class="citref" style="padding:0.2em;"><img style="border:0;text-align:left;height:15px;width:15px;margin-right:0.2em" src="//pubchem.ncbi.nlm.nih.gov/images/PubMed.gif"> <span style="color:#444"> Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. </span> <cite><a class="link" href="//www.ncbi.nlm.nih.gov/pubmed/24319143">"<span style="font-style:italic;"> MMDB and VAST+: tracking structural similarities between macromolecular complexes. <b style="font-size:90%">Nucleic Acids Res. 2014 Jan; 42(Database issue)</b>:D297-303</span></a></cite></div></div>
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<!-- end citation -->
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