211 lines
27 KiB
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211 lines
27 KiB
Text
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<title>6R7F: Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome</title>
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<meta name="keywords" content="COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, COP9 signalosome complex subunit 4, COP9 signalosome complex subunit 5, COP9 signalosome complex subunit 6, COP9 signalosome complex subunit 7b, COP9 signalosome complex subunit 8, Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, Elongin-C, NEDD8, von Hippel-Lindau disease tumor suppressor, MMDB, Protein structure, protein interaction">
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<table cellspacing="0" id="mmdb_logo_links" cellpadding="0" width="100%"><tr><td><a class="ncbi_home_logo" href="/" alt="NBI HOME Logo">NCBI</a><div class="NLMLogo">National Center for<br/>Biotechnology Information</div></td><td class="titletext" align="left"><!--a href="/Structure/MMDB/mmdb.shtml"--><img border=0 src="/Structure/MMDB/strbanner.jpg" alt="6R7F - NCBI MMDB Logo"><!--/a--></td><td style="padding-bottom:1em;vertical-align:bottom"><form id="mmdbsearch" method="get" name="mmdbsearch" action="/Structure/pdb/" style="margin:0;padding:0;vertical-align: bottom;"><div class="mmdb-search-holder" style="height:100%;line-height:100%"><input accesskey="S" id="mmdb-search-box" type="search" name="uid" placeholder="Enter PDB ID or MMDB ID" value = "" aria-describedby="mmdb-search-uid" title="Enter PDB ID or MMDB ID"><button id="mmdb-search-button" class="__button mmdb-search-button" style="height:100%;line-height:100%;margin-right:-3px;" type="submit">Search</button></div></form></td></tr></table>
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<section data-section="infor" id="structure-infor-section"><h1 class="structure-title" data-mmdbid="178976" data-pdbid="6R7F" id="structure-title"><a class="link title-pdbid" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=6R7F" style="font-weight:600;margin:0;">6R7F: </a><span>Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome</span></h1>
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<div class="floatClear" id="infor-detail"><div class="reference_section" data-pmids="31444342" id="reference-section"></div>
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<div class="property_section"><form action="/Structure/mmdb/mmdbsrv.cgi" method="post" id="reloadform" name="reloadform" style="margin:0;padding:0"><input type="hidden" name="uid" value="178976"/></form><table border="0" cellpadding="4" cellspacing="4"><tr><td class="H4 pdbid-download">PDB ID: </td>
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<td><a id="pdb_id_link" class="link" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=6R7F" title="PDB ID">6R7F</a><a id="download-pdb-file" class="__button" tabindex="-1" href="https://files.rcsb.org/download/6R7F.pdb" title="Download PDB file" download="6R7F.pdb">Download</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvStructureViewDataSetPDBdataset" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">MMDB ID: </td>
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<td style="font-weight:bold"><span class="info-item">178976</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvRecordIdentifiers" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">PDB Deposition Date: </td>
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<td><span id="depositionterm" style="padding-left: 0.2em;">2019/3/28<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDeposited" title="-click to see help"></a></span></td>
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<tr><td class="H4 property-name">Updated in MMDB: </td>
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<td class="text" nowrap><span id="mmdb_updated" style="padding-left:0.2em">2019/10</span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvUpdatedInMMDB" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">Experimental Method: </td>
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<td class="TEXT" nowrap><div id="expmethod"><span title="electron microscopy" class="info-item">electron microscopy</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvExperimentalMethod" title="-click to see help"></a></div></td>
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</tr>
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<tr><td class="H4 property-name">Resolution: </td>
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<td class="TEXT" id="resolution" nowrap>8.2 Å<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#SearchFieldResolution" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">Source Organism: </td>
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<td class="text"><div id="taxonomy"><a id="taxword" class="link" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=9606" title="Homo sapiens">Homo sapiens</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvTaxonomy" title="-click to see help"></a></div></td>
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<tr><td class="H4 property-name">Similar Structures: </td>
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<td><div id="vast-button-holder" style="width:100%;overflow:hidden;"><button class="__button" id="vast_button" type="submit">VAST+</button>
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<a class="help-img" href="/Structure/vastplus/docs/vastplus_help.html" title="-click to see help"></a></div></td>
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<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDownaloadSequenceMMDB" title="-click to see help"></a></td></tr>
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</section>
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<!-- start annotations -->
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<div align="center" id="annotblock" style="margin-top:0.8em;"><div class="formbox" id="asublock"><div id="asublock"><style>.unitschema-0{
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background-image:url("/Structure/mmdb/mmdbimage.fcgi?uid=178976&type=2&unm=0");
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}</style><section class="graph-section" data-section="graph" id="biounit-section-0"></section>
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<section class="content_block" data-section="table"><table border="1" class="bucontent"><caption class="butbl_caption">Molecular Components in 6R7F<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents" title="-click to see help"></a></caption>
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<thead><tr><th>Label</th>
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<th>Count</th>
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<th>Molecule</th>
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</tr></thead>
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<tbody data-bun="0" data-type="protein" id="unit0_protein_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Proteins (14 molecules)</div></td></tr>
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<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-1" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_A" id="mol-legend-0-1" class="protein-molecule-label-1" data-gi="1732262053" data-molid="1" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">A</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 1">Cop9 Signalosome Complex Subunit 1</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2873" alt="G protein pathway suppressor 1">GPS1</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="1" data-molids="1" id="molgraph-p-0-1"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-2" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_B" id="mol-legend-0-2" class="protein-molecule-label-1" data-gi="1732262054" data-molid="2" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">B</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 2">Cop9 Signalosome Complex Subunit 2</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/9318" alt="COP9 signalosome subunit 2">COPS2</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="2" data-molids="2" id="molgraph-p-0-2"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="2"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-3" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_C" id="mol-legend-0-3" class="protein-molecule-label-1" data-gi="1732262055" data-molid="3" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">C</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 3">Cop9 Signalosome Complex Subunit 3</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/8533" alt="COP9 signalosome subunit 3">COPS3</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="3" data-molids="3" id="molgraph-p-0-3"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="3"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-4" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_D" id="mol-legend-0-4" class="protein-molecule-label-1" data-gi="1732262056" data-molid="4" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">D</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 4">Cop9 Signalosome Complex Subunit 4</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/51138" alt="COP9 signalosome subunit 4">COPS4</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="4" data-molids="4" id="molgraph-p-0-4"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="4"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-5" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_E" id="mol-legend-0-5" class="protein-molecule-label-1" data-gi="1732262057" data-molid="5" style="color:#000000;background-color:#CCCCCC" title="-Select icon for molecule information"><div class="protein-table-chain-label">E</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 5">Cop9 Signalosome Complex Subunit 5</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/10987" alt="COP9 signalosome subunit 5">COPS5</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="5" data-molids="5" id="molgraph-p-0-5"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="5"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-6" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_F" id="mol-legend-0-6" class="protein-molecule-label-1" data-gi="1732262058" data-molid="6" style="color:#000000;background-color:#FF9900" title="-Select icon for molecule information"><div class="protein-table-chain-label">F</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 6">Cop9 Signalosome Complex Subunit 6</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/10980" alt="COP9 signalosome subunit 6">COPS6</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="6" data-molids="6" id="molgraph-p-0-6"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="6"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-7" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_H" id="mol-legend-0-7" class="protein-molecule-label-1" data-gi="1732262059" data-molid="7" style="color:#000000;background-color:#FF6666" title="-Select icon for molecule information"><div class="protein-table-chain-label">H</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 8">Cop9 Signalosome Complex Subunit 8</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/10920" alt="COP9 signalosome subunit 8">COPS8</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="7" data-molids="7" id="molgraph-p-0-7"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="7"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-8" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_G" id="mol-legend-0-8" class="protein-molecule-label-1" data-gi="1732262060" data-molid="8" style="color:#000000;background-color:#00FF00" title="-Select icon for molecule information"><div class="protein-table-chain-label">G</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 7B">Cop9 Signalosome Complex Subunit 7B</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/64708" alt="COP9 signalosome subunit 7B">COPS7B</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="8" data-molids="8" id="molgraph-p-0-8"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="8"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-9" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_V" id="mol-legend-0-9" class="protein-molecule-label-1" data-gi="1732262061" data-molid="9" style="color:#000000;background-color:#00FFFF" title="-Select icon for molecule information"><div class="protein-table-chain-label">V</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="VON Hippel-lindau Disease Tumor Suppressor">VON Hippel-lindau Disease Tumor Suppressor</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/7428" alt="von Hippel-Lindau tumor suppressor">VHL</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="9" data-molids="9" id="molgraph-p-0-9"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="9"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-10" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_P" id="mol-legend-0-10" class="protein-molecule-label-1" data-gi="1732262062" data-molid="10" style="color:#000000;background-color:#FFFF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">P</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Elongin-b">Elongin-b</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/6923" alt="elongin B">ELOB</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="10" data-molids="10" id="molgraph-p-0-10"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="10"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-11" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_Q" id="mol-legend-0-11" class="protein-molecule-label-1" data-gi="1732262063" data-molid="11" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">Q</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Elongin-c">Elongin-c</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/6921" alt="elongin C">ELOC</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="11" data-molids="11" id="molgraph-p-0-11"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="11"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-12" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_O" id="mol-legend-0-12" class="protein-molecule-label-1" data-gi="1732262064" data-molid="12" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">O</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cullin-2">Cullin-2</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/8453" alt="cullin 2">CUL2</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="12" data-molids="12" id="molgraph-p-0-12"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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<tr data-row="12"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-13" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_R" id="mol-legend-0-13" class="protein-molecule-label-1" data-gi="1732262065" data-molid="13" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">R</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="E3 Ubiquitin-protein Ligase Rbx1">E3 Ubiquitin-protein Ligase Rbx1</div>
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<div class="annot-img-block" data-bun="0" data-gmolid="13" data-molids="13" id="molgraph-p-0-13"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="13"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-14" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_N" id="mol-legend-0-14" class="protein-molecule-label-1" data-gi="1732262066" data-molid="14" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">N</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Nedd8">Nedd8</div>
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<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/4738" alt="NEDD8 ubiquitin like modifier">NEDD8</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="14" data-molids="14" id="molgraph-p-0-14"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</tbody>
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</table>
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<div style="margin:0.5em 1em;text-align:left; font-size:85%;">* Click molecule labels to explore molecular sequence information.<br/></div>
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</section>
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</div></div></div>
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<!-- end annotations -->
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</table>
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<!-- Start of citation -->
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<div align="left" class="citing"><hr width="85%"/><div style="font-weight:bold">Citing MMDB</div><div class="citref" style="padding:0.2em;"><img style="border:0;text-align:left;height:15px;width:15px;margin-right:0.2em" src="//pubchem.ncbi.nlm.nih.gov/images/PubMed.gif"> <span style="color:#444"> Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. </span> <cite><a class="link" href="//www.ncbi.nlm.nih.gov/pubmed/24319143">"<span style="font-style:italic;"> MMDB and VAST+: tracking structural similarities between macromolecular complexes. <b style="font-size:90%">Nucleic Acids Res. 2014 Jan; 42(Database issue)</b>:D297-303</span></a></cite></div></div>
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