nih-gov/www.ncbi.nlm.nih.gov/Structure/pdb/6R7F
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<title>6R7F: Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome</title>
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<section data-section="infor" id="structure-infor-section"><h1 class="structure-title" data-mmdbid="178976" data-pdbid="6R7F" id="structure-title"><a class="link title-pdbid" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=6R7F" style="font-weight:600;margin:0;">6R7F: </a><span>Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome</span></h1>
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<td><a id="pdb_id_link" class="link" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=6R7F" title="PDB ID">6R7F</a><a id="download-pdb-file" class="__button" tabindex="-1" href="https://files.rcsb.org/download/6R7F.pdb" title="Download PDB file" download="6R7F.pdb">Download</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvStructureViewDataSetPDBdataset" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">MMDB ID: </td>
<td style="font-weight:bold"><span class="info-item">178976</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvRecordIdentifiers" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">PDB Deposition Date: </td>
<td><span id="depositionterm" style="padding-left: 0.2em;">2019/3/28<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDeposited" title="-click to see help"></a></span></td>
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<tr><td class="H4 property-name">Updated in MMDB: </td>
<td class="text" nowrap><span id="mmdb_updated" style="padding-left:0.2em">2019/10</span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvUpdatedInMMDB" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">Experimental Method: </td>
<td class="TEXT" nowrap><div id="expmethod"><span title="electron microscopy" class="info-item">electron microscopy</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvExperimentalMethod" title="-click to see help"></a></div></td>
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<td class="TEXT" id="resolution" nowrap>8.2&nbsp; &#197;<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#SearchFieldResolution" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">Source Organism: </td>
<td class="text"><div id="taxonomy"><a id="taxword" class="link" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=9606" title="Homo sapiens">Homo sapiens</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvTaxonomy" title="-click to see help"></a></div></td>
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<tr><td class="H4 property-name">Similar Structures: </td>
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<section class="content_block" data-section="table"><table border="1" class="bucontent"><caption class="butbl_caption">Molecular Components in 6R7F<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents" title="-click to see help"></a></caption>
<thead><tr><th>Label</th>
<th>Count</th>
<th>Molecule</th>
</tr></thead>
<tbody data-bun="0" data-type="protein" id="unit0_protein_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Proteins (14 molecules)</div></td></tr>
<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-1" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_A" id="mol-legend-0-1" class="protein-molecule-label-1" data-gi="1732262053" data-molid="1" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">A</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 1">Cop9 Signalosome Complex Subunit 1</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2873" alt="G protein pathway suppressor 1">GPS1</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="1" data-molids="1" id="molgraph-p-0-1"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-2" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_B" id="mol-legend-0-2" class="protein-molecule-label-1" data-gi="1732262054" data-molid="2" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">B</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 2">Cop9 Signalosome Complex Subunit 2</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/9318" alt="COP9 signalosome subunit 2">COPS2</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="2" data-molids="2" id="molgraph-p-0-2"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="2"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-3" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_C" id="mol-legend-0-3" class="protein-molecule-label-1" data-gi="1732262055" data-molid="3" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">C</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 3">Cop9 Signalosome Complex Subunit 3</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/8533" alt="COP9 signalosome subunit 3">COPS3</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="3" data-molids="3" id="molgraph-p-0-3"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="3"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-4" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_D" id="mol-legend-0-4" class="protein-molecule-label-1" data-gi="1732262056" data-molid="4" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">D</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 4">Cop9 Signalosome Complex Subunit 4</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/51138" alt="COP9 signalosome subunit 4">COPS4</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="4" data-molids="4" id="molgraph-p-0-4"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="4"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-5" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_E" id="mol-legend-0-5" class="protein-molecule-label-1" data-gi="1732262057" data-molid="5" style="color:#000000;background-color:#CCCCCC" title="-Select icon for molecule information"><div class="protein-table-chain-label">E</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 5">Cop9 Signalosome Complex Subunit 5</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/10987" alt="COP9 signalosome subunit 5">COPS5</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="5" data-molids="5" id="molgraph-p-0-5"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="5"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-6" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_F" id="mol-legend-0-6" class="protein-molecule-label-1" data-gi="1732262058" data-molid="6" style="color:#000000;background-color:#FF9900" title="-Select icon for molecule information"><div class="protein-table-chain-label">F</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 6">Cop9 Signalosome Complex Subunit 6</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/10980" alt="COP9 signalosome subunit 6">COPS6</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="6" data-molids="6" id="molgraph-p-0-6"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="6"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-7" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_H" id="mol-legend-0-7" class="protein-molecule-label-1" data-gi="1732262059" data-molid="7" style="color:#000000;background-color:#FF6666" title="-Select icon for molecule information"><div class="protein-table-chain-label">H</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 8">Cop9 Signalosome Complex Subunit 8</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/10920" alt="COP9 signalosome subunit 8">COPS8</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="7" data-molids="7" id="molgraph-p-0-7"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="7"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-8" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_G" id="mol-legend-0-8" class="protein-molecule-label-1" data-gi="1732262060" data-molid="8" style="color:#000000;background-color:#00FF00" title="-Select icon for molecule information"><div class="protein-table-chain-label">G</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cop9 Signalosome Complex Subunit 7B">Cop9 Signalosome Complex Subunit 7B</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/64708" alt="COP9 signalosome subunit 7B">COPS7B</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="8" data-molids="8" id="molgraph-p-0-8"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="8"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-9" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_V" id="mol-legend-0-9" class="protein-molecule-label-1" data-gi="1732262061" data-molid="9" style="color:#000000;background-color:#00FFFF" title="-Select icon for molecule information"><div class="protein-table-chain-label">V</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="VON Hippel-lindau Disease Tumor Suppressor">VON Hippel-lindau Disease Tumor Suppressor</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/7428" alt="von Hippel-Lindau tumor suppressor">VHL</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="9" data-molids="9" id="molgraph-p-0-9"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="9"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-10" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_P" id="mol-legend-0-10" class="protein-molecule-label-1" data-gi="1732262062" data-molid="10" style="color:#000000;background-color:#FFFF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">P</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Elongin-b">Elongin-b</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/6923" alt="elongin B">ELOB</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="10" data-molids="10" id="molgraph-p-0-10"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="10"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-11" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_Q" id="mol-legend-0-11" class="protein-molecule-label-1" data-gi="1732262063" data-molid="11" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">Q</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Elongin-c">Elongin-c</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/6921" alt="elongin C">ELOC</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="11" data-molids="11" id="molgraph-p-0-11"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="11"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-12" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_O" id="mol-legend-0-12" class="protein-molecule-label-1" data-gi="1732262064" data-molid="12" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">O</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cullin-2">Cullin-2</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/8453" alt="cullin 2">CUL2</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="12" data-molids="12" id="molgraph-p-0-12"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="12"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-13" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_R" id="mol-legend-0-13" class="protein-molecule-label-1" data-gi="1732262065" data-molid="13" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">R</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="E3 Ubiquitin-protein Ligase Rbx1">E3 Ubiquitin-protein Ligase Rbx1</div>
<div class="annot-img-block" data-bun="0" data-gmolid="13" data-molids="13" id="molgraph-p-0-13"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="13"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-0-14" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/6R7F_N" id="mol-legend-0-14" class="protein-molecule-label-1" data-gi="1732262066" data-molid="14" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">N</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Nedd8">Nedd8</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/4738" alt="NEDD8 ubiquitin like modifier">NEDD8</a>)</div><div class="annot-img-block" data-bun="0" data-gmolid="14" data-molids="14" id="molgraph-p-0-14"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
</tbody>
</table>
<div style="margin:0.5em 1em;text-align:left; font-size:85%;">&#42; Click molecule labels to explore molecular sequence information.<br/></div>
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<div align="left" class="citing"><hr width="85%"/><div style="font-weight:bold">Citing MMDB</div><div class="citref" style="padding:0.2em;"><img style="border:0;text-align:left;height:15px;width:15px;margin-right:0.2em" src="//pubchem.ncbi.nlm.nih.gov/images/PubMed.gif"> <span style="color:#444"> Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. </span> <cite><a class="link" href="//www.ncbi.nlm.nih.gov/pubmed/24319143">"<span style="font-style:italic;"> MMDB and VAST+: tracking structural similarities between macromolecular complexes. <b style="font-size:90%">Nucleic Acids Res. 2014 Jan; 42(Database issue)</b>:D297-303</span></a></cite></div></div>
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