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<!-- P class="indent10bottomspace"><A HREF="/mailman/listinfo/cdd-announce"><B>CDD-announce Mailing List</B></A></P -->
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<P class="indent20 NormalText">To receive e-mail news about changes to the <A HREF="/cdd/">Conserved Domain Database</A> and its associated <A HREF="../cdd.shtml">resources</A>, subscribe to the <A HREF="/mailman/listinfo/cdd-announce"><SPAN style="color:#D70000">cdd-announce@ncbi.nlm.nih.gov mailing list</SPAN></A> by completing a <A HREF="/mailman/listinfo/cdd-announce">brief form</A> or sending an e-mail message with the word <I>subscribe</I> in the subject line to <I>cdd-announce-request@ncbi.nlm.nih.gov</I>.</P>
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<P class="indent10bottomspace TOCText"><B>CDD v3.__</B></P>
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<P class="indent20 NormalText">
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[__ MAR 2014]  A new version of the Conserved Domain Database has been released. Version 3.__ contains ____ new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains. You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>.
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<BR>OR<BR>
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[__ MAR 2014]  The CDD v3.__ release includes ___ new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>.
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<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.21"></A><B>CDD v3.21</B></P>
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<P class="indent20 NormalText">[20 SEP 2022]  A new version of the <A HREF="/cdd/">Conserved Domain Database</A> has been released. Version 3.21 contains 1,174 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains and now mirrors <A HREF="http://pfam.xfam.org/">Pfam</A> version 35 as well as <A HREF="/cdd?cmd=search&term=%22ncbifams%22%5BDatabase%5D">new models from</A> the <A HREF="../cdd_help.shtml#CDSource_NCBIfams">NCBIfam</A> collection and revised models from the <A HREF="/research/cog">COGs</A> database. Fine-grained classifications of the
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<a href="/Structure/cdd/cddsrv.cgi?uid=cd00012">Acetate and Sugar Kinases/Hsc70/Actin</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=cd00136">PDZ canonical domains</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=cd00117">three-fingered protein (TFP) fold</a>, and <a href="/Structure/cdd/cddsrv.cgi?uid=cd00161">ricin-like beta-trefoil</a> superfamilies have been added, amongst many other new models.
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You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>.</P>
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<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.20"></A><B>CDD v3.20</B></P>
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<P class="indent20 NormalText">[20 SEP 2022]  A new version of the <A HREF="/cdd/">Conserved Domain Database</A> has been released. Version 3.20 contains 1,614 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains and now mirrors <A HREF="http://pfam.xfam.org/">Pfam</A> version 34 as well as <A HREF="/cdd?cmd=search&term=%22ncbifams%22%5BDatabase%5D">new models from</A> the <A HREF="../cdd_help.shtml#CDSource_NCBIfams">NCBIfam</A> collection. Fine-grained classifications of the
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<a href="/Structure/cdd/cddsrv.cgi?uid=cd23167">[(+)ssRNA] virus RNA-dependent RNA polymerase catalytic domain</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=cd00162">RING-finger/U-box</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=cd22957">dimerization/docking domains of the cAMP-dependent protein kinase regulatory subunit</a>, and <a href="/Structure/cdd/cddsrv.cgi?uid=cd22823">Galactose/rhamnose-binding lectin domain</a> superfamilies have been added, amongst many other new models.
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You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>.</P>
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<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.19"></A><B>CDD v3.19</B></P>
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<P class="indent20 NormalText">[8 MAR 2021]  A new version of the <A HREF="/cdd/">Conserved Domain Database</A> has been released. Version 3.19 contains 3,148 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains and now mirrors <A HREF="http://pfam.xfam.org/">Pfam</A> version 33.1 as well as <A HREF="/cdd?cmd=search&term=%22ncbifams%22%5BDatabase%5D">models from</A> the <A HREF="../cdd_help.shtml#CDSource_NCBIfams">NCBIfam</A> collection. Fine-grained classifications of the
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<a href="/Structure/cdd/cddsrv.cgi?uid=409353">immunoglobulin</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=409669">RRM</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=410651">cytochrome P450</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=410628">7-transmembrane GPCRs</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=411802">KH</a>, <a href="/Structure/cdd/cddsrv.cgi?uid=409031">calponin homology</a> and <a href="/Structure/cdd/cddsrv.cgi?uid=410341">C1 domain</a> superfamilies have also been added.
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With this release, CDD introduces model-specific word-score thresholds for the <A HREF="/Structure/cdd/cdd_help.shtml#RPSBWhat">RPS-BLAST</a> heuristics. These are included in the position-specific score matrices (<A HREF="/Structure/cdd/cdd_help.shtml#CD_PSSM">PSSMs</a>) and are used by database formatting software when constructing word lookup tables for the BLAST heuristics stage. The current implementation results in a 3-fold speedup of RPS-BLAST searches and misses annotation for about 0.6% of query proteins, mostly at the borderline of significance.
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You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>.</P>
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<P class="indent10bottomspace TOCText"><A NAME="COVID_19"></A><B>New viral protein domain models for annotation of coronaviruses</B></P>
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<P class="indent20 NormalText">[30 APR 2020]  NLM's <a href="/cdd/">Conserved Domain Database (CDD)</a> has expanded its scope to now include <a href="https://icn3d.page.link/8BDNCRb21Li9ugT38">153 new viral protein domain family models</a> for the annotation of coronaviruses, including models such as for the <a href="/Structure/cdd/cddsrv.cgi?uid=cd21527">S1 subunit of coronavirus Spike proteins (cd21527)</a><!-- uid 394949 -->, the <a href="/Structure/cdd/cddsrv.cgi?uid=cd21595">nucleocapsid (N) protein of coronavirus (cd21595)</a><!--uid 394954 -->, and the <a href="/Structure/cdd/cddsrv.cgi?uid=cd21530">coronavirus RNA-dependent RNA polymerase (cd21530)</a><!-- uid 394890 -->. Each <a href="../cdd_help.shtml#CDSource_NCBI_curated">curated</a> domain model consists of a multiple sequence alignment illustrating conserved amino acids and may define <a href="../cdd_help.shtml#ConservedFeatures">conserved sequence features</a> that have been confirmed experimentally, plus links to relevant publications. When available, the <a href="../cdd_help.shtml#Include3DStruct">domain models include 3D structures</a> with links to interactive 3D views and interacting partners.<br></br>
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A <a href="/Structure/SARS-CoV-2.html">tabular summary of SARS-CoV-2 gene products</a> along with links to matching conserved domain models and representative 3D protein structures is available here.</P>
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<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.18"></A><B>CDD v3.18</B></P>
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<P class="indent20 NormalText">[26 MAR 2020]  A new version of the <A HREF="/cdd/">Conserved Domain Database</A> has been released. Version 3.18 contains 2,128 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains and now mirrors <A HREF="http://pfam.xfam.org/">Pfam</A> version 32 as well as <A HREF="/cdd?cmd=search&term=%22ncbifams%22%5BDatabase%5D">models from</A> the <A HREF="../cdd_help.shtml#CDSource_NCBIfams">NCBIfam</A> collection. Fine-grained classifications of the <a href="/Structure/cdd/cddsrv.cgi?uid=cl40423&spf=1">cupin</a> and <a href="/Structure/cdd/cddsrv.cgi?uid=cl10011&spf=1">PBP1</a> superfamilies have also been added. You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>.</P>
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<P class="indent10bottomspace TOCText"><A NAME="CDD_SPARCLE_202001_NAR"></A><B>Print version now available</B></P>
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<P class="indent20 NormalText">[08 JAN 2020]  The print version of "CDD/SPARCLE: the conserved domain database in 2020"  by Lu S et al. is now available in the Nucleic Acids Research database issue (<a href="/pubmed/31777944">PubMed ID 31777944</a>; <a href="https://academic.oup.com/nar/article/48/D1/D265/5645006">full text at Oxford Academic</a>; <a href="/pmc/articles/PMC6943070/">full text in PubMed Central</a>).<br>
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<!-- i>(A separate page lists <A HREF="cdd_publications.html">all publications</A> about NCBI's <A HREF="../cdd.shtml">Conserved Domains and Protein Classification Resources</A>.)</i -->
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<P class="indent10bottomspace TOCText"><A NAME="CDD_SPARCLE_201911_NAR"></A><B>CDD/SPARCLE: the conserved domain database in 2020</B></P>
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<P class="indent20 NormalText">[28 NOV 2019]  An article by Lu S et al., about the NCBI Conserved Domain Database became available in Nucleic Acids Research as an e-publication ahead of print (<a href="/pubmed/31777944">PubMed ID 31777944</a>):
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"As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as a publicly available resource, CDD curation staff continues to develop hierarchical classifications of widely distributed protein domain families, and to record conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research..." <a href="/pubmed/31777944"><i>(read more...)</i></a><br>
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<!-- i>(A separate page lists <A HREF="cdd_publications.html">all publications</A> about NCBI's <A HREF="../cdd.shtml">Conserved Domains and Protein Classification Resources</A>.)</i -->
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<P class="indent10bottomspace TOCText"><A HREF="___"><B>Header (e.g., other)</B></A></P>
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<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
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<!-- TABLE width="100%" border="0" cellspacing="0" cellpadding="0">
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||
<TR>
|
||
<TD class="WhiteCell NormalText"> </TD>
|
||
</TR>
|
||
</TABLE -->
|
||
|
||
</TD>
|
||
|
||
<!-- ============== END_CONTENT_AREA_ROW_1_CELL_1 ================= -->
|
||
|
||
|
||
<!-- ============== CONTENT_AREA_ROW_1_CELL_2 ================ -->
|
||
|
||
<TD WIDTH="300" class="Yellow1CellBlueEdge" ALIGN="LEFT" VALIGN="TOP">
|
||
|
||
|
||
<!-- ============== BOX2_DATABASE_STATISTICS ================ -->
|
||
|
||
<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0">
|
||
|
||
<!-- ########## BLUE_HEADER ########## -->
|
||
<TR>
|
||
<TD class="SteelBlueCell HeaderText2B" ALIGN="LEFT" VALIGN="TOP">Database Statistics</TD>
|
||
</TR>
|
||
<!-- ########## END_BLUE_HEADER ########## -->
|
||
|
||
<TR>
|
||
<TD class="Yellow1Cell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<!-- ======== SINGLE_THUMBNAIL ======= -->
|
||
|
||
<TR>
|
||
<TD class="Yellow1Cell NormalText" ALIGN="Center" VALIGN="TOP">
|
||
<TABLE width="100%" border="0" cellspacing="0" cellpadding="0">
|
||
|
||
<TR>
|
||
<TD class="Yellow1Cell ThumbText2" ALIGN="Center" VALIGN="TOP" colspan="3">
|
||
<SPAN class="ThumbText2"><A HREF="/cdd?cmd=search&term=%22all%22%5BFilter%5D"><B>CDD v3.21, as of 31 March 2024:</B></A></SPAN><BR><BR>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="Yellow1Cell ThumbText2" ALIGN="Left" VALIGN="TOP" WIDTH="20"> </TD>
|
||
<TD class="Yellow1Cell ThumbText2" ALIGN="Left" VALIGN="TOP">
|
||
|
||
<TABLE width="100%" border="0" cellspacing="0" cellpadding="2" class="format3">
|
||
|
||
<!-- TR>
|
||
<TD class="ThumbText2 format3H" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
Retrieve</TD>
|
||
<TD class="ThumbText2 format3H" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
domains from <A HREF="../cdd_help.shtml#CDSource"><I>Source Databases:</I></A></TD>
|
||
</TR -->
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3H" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22all%22%5BFilter%5D"><I><B>64,456</B></I></A></TD>
|
||
<TD class="ThumbText2 format3H" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
total models from all <A HREF="../cdd_help.shtml#CDSource"><I><B>Source Databases</B></I></A></TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3A" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22cdd%22%5BDatabase%5D"><I><B>19,902</B></I></A></TD>
|
||
<TD class="ThumbText2 format3B" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
models from <A HREF="../cdd_help.shtml#CDSource_NCBI_curated"><I><B>NCBI CDD curation effort</B></I></A></TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3A" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22ncbifams%22%5BDatabase%5D"><I><B>2,142</B></I></A></TD>
|
||
<TD class="ThumbText2 format3B" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
models from <A HREF="../cdd_help.shtml#CDSource_NCBIfams"><I><B>NCBIfams</B></I></A><!-- v6.0 --></TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3A" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22smart%22%5BDatabase%5D"><I><B>1,009</B></I></A></TD>
|
||
<TD class="ThumbText2 format3B" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
models from <A HREF="http://smart.embl-heidelberg.de/"><I><B>SMART</B></I></A> v6.0</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3A" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22pfam%22%5BDatabase%5D"><I><B>19,637</B></I></A></TD>
|
||
<TD class="ThumbText2 format3B" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
models from <A HREF="http://pfam.xfam.org/"><I><B>PFAM</B></I></A> v35</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3A" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22cog%22%5BDatabase%5D"><I><B>5,137</B></I></A></TD>
|
||
<TD class="ThumbText2 format3B" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
models from <A HREF="/COG/"><I><B>COGs</B></I></A> v2.0</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3A" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22prk%22%5BDatabase%5D"><I><B>10,140</B></I></A></TD>
|
||
<TD class="ThumbText2 format3B" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
models from <A HREF="/proteinclusters"><I><B>Entrez Protein Clusters</B></I></A><!-- v6.0 --></TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3A" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22tigr%22%5BDatabase%5D"><I><B>4,488</B></I></A></TD>
|
||
<TD class="ThumbText2 format3B" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
models from <A HREF="tigrfams.html"><I><B>TIGRFAM</B></I></A> v14</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="ThumbText2 format3H" ALIGN="left" VALIGN="TOP" style="white-space: nowrap;" colspan="2">organized into <A HREF="/cdd?cmd=search&term=%22cdart%22%5BDatabase%5D"><I><B>4,705</B></I></A> multi-model <A HREF="../cdd_help.shtml#Superfamily"><I><B>Superfamilies</B></I></A></TD>
|
||
</TR>
|
||
|
||
<!-- TR>
|
||
<TD class="ThumbText2 format3A" ALIGN="right" VALIGN="TOP" style="white-space: nowrap;">
|
||
<A HREF="/cdd?cmd=search&term=%22___%22%5BDatabase%5D"><I>_____</I></A></TD>
|
||
<TD class="ThumbText2 format3B" ALIGN="Left" VALIGN="TOP" style="white-space: nowrap;">
|
||
from <A HREF="_____"><I>______</I></A></TD>
|
||
</TR -->
|
||
|
||
</TABLE>
|
||
|
||
</TD>
|
||
|
||
<TD class="Yellow1Cell ThumbText2" ALIGN="Left" VALIGN="TOP" WIDTH="20"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="Yellow1Cell ThumbText2" ALIGN="Left" VALIGN="TOP" WIDTH="20"> </TD>
|
||
<TD class="Yellow1Cell ThumbText2" ALIGN="Center" VALIGN="TOP">
|
||
<BR><I>Click on the numbers above to retrieve the domain records from CDD; click on the source database names for additional details.<!-- The PRK version number is something we make up, and it<69>s just a counter that tells us how often we have mirrored the PRK resource. --></I>
|
||
</TD>
|
||
<TD class="Yellow1Cell ThumbText2" ALIGN="Left" VALIGN="TOP" WIDTH="20"> </TD>
|
||
</TR>
|
||
|
||
</TABLE>
|
||
</TD>
|
||
</TR>
|
||
|
||
</TABLE>
|
||
|
||
<!-- ======================== END_BOX2 =========================== -->
|
||
|
||
<BR>
|
||
|
||
</TD>
|
||
|
||
<!-- ======== END_CONTENT_AREA_ROW_1_CELL_2 ========== -->
|
||
|
||
<!-- ======== CONTENT_AREA_ROW_1_CELL_3 ========== -->
|
||
|
||
<TD class="WhiteCell" width="8"></TD>
|
||
|
||
<!-- ======== END_CONTENT_AREA_ROW_1_CELL_3 ========== -->
|
||
|
||
</TR>
|
||
</TABLE>
|
||
|
||
<!-- =========== END_CONTENT_AREA_WHATS_NEW_AND_STATS =============== -->
|
||
|
||
<!-- ===== VERTICAL_SPACER_SEPARATING_WHATS_NEW_AND_NEWS_ARCHIVE ===== -->
|
||
|
||
<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0">
|
||
<TR>
|
||
<TD class="WhiteCell MiniText"> </TD>
|
||
</TR>
|
||
</TABLE>
|
||
|
||
<!-- ============= CONTENT_AREA_NEWS_ARCHIVE ================ -->
|
||
|
||
<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0" bgcolor="#FFFFFF">
|
||
|
||
<TR>
|
||
|
||
<!-- ============= CONTENT_AREA_ROW_2_CELL_1 ========== -->
|
||
|
||
<TD class="WhiteCell" width="8"></TD>
|
||
|
||
<!-- ============= END_CONTENT_AREA_ROW_2_CELL_1 ========== -->
|
||
|
||
|
||
<!-- ============= CONTENT_AREA_ROW_2_CELL_2 ========== -->
|
||
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
|
||
<!-- ==================== BOX3_NEWS_ARCHIVE ====================== -->
|
||
|
||
<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0" class="WhiteCellBlueEdgeAll">
|
||
|
||
<!-- ########## BLUE_HEADER ########## -->
|
||
<TR>
|
||
<TD class="SteelBlueCell HeaderText2B" ALIGN="LEFT" VALIGN="TOP">News Archive</TD>
|
||
</TR>
|
||
<!-- ########## END_BLUE_HEADER ########## -->
|
||
|
||
<TR>
|
||
<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<!-- ==================== YEARS_NAVIGATION ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell" ALIGN="LEFT" VALIGN="TOP">
|
||
<TABLE border="0" cellspacing="2" cellpadding="0" class="WhiteCell ThumbText">
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="10" ALIGN="Center" VALIGN="Center"> </TD>
|
||
<TD class="HowToButton" ALIGN="Center" VALIGN="Center">
|
||
 <A HREF="#2009"><B>2009</B></A> </TD>
|
||
<TD class="HowToButton" ALIGN="Center" VALIGN="Center">
|
||
 <A HREF="#2008"><B>2008</B></A> </TD>
|
||
<TD class="HowToButton" ALIGN="Center" VALIGN="Center">
|
||
 <A HREF="#____"><B>2007</B></A> </TD>
|
||
<TD class="HowToButton" ALIGN="Center" VALIGN="Center">
|
||
 <A HREF="#____"><B>2006</B></A> </TD>
|
||
<TD class="HowToButton" ALIGN="Center" VALIGN="Center">
|
||
 <A HREF="#____"><B>20XX</B></A> </TD>
|
||
</TR>
|
||
</TABLE>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== 2009_HEADER ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell" ALIGN="LEFT" VALIGN="TOP">
|
||
<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" class="WhiteCell TOCText2">
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP">
|
||
<A NAME="2009"><B>2009</B></A>
|
||
</TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"><A HREF="#Top"><img SRC="../../IMG/arrowup_blue.gif" width="12" height="12" border="0" alt="back to top"></A></TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP"><HR></TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"> </TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
</TABLE>
|
||
</TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_2009_HEADER ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="#___"><B>Header (e.g., specific hits)</B></A></P>
|
||
<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="#___"><B>Header (e.g., superfamilies)</B></A></P>
|
||
<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_2009_NEWS ==================== -->
|
||
|
||
<!-- ==================== 2008_HEADER ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell" ALIGN="LEFT" VALIGN="TOP">
|
||
<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" class="WhiteCell TOCText2">
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP">
|
||
<A NAME="2008"><B>2008</B></A>
|
||
</TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"><A HREF="#Top"><img SRC="../../IMG/arrowup_blue.gif" width="12" height="12" border="0" alt="back to top"></A></TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP"><HR></TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"> </TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
</TABLE>
|
||
</TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_2008_HEADER ==================== -->
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.17"></A><B>CDD v3.17</B></P>
|
||
<P class="indent20 NormalText">[03 APR 2019]  A new version of the <A HREF="/cdd/">Conserved Domain Database</A> has been released. Version 3.17 contains 3,272 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains and now mirrors <A HREF="http://pfam.xfam.org/">Pfam</A> version 31 as well as <A HREF="/cdd?cmd=search&term=%22ncbifams%22%5BDatabase%5D">models from</A> <A HREF="../cdd_help.shtml#CDSource_NCBIfams">NCBIfams</A>, a collection of protein family hidden Markov models (HMMs) for improving bacterial genome annotation. A fine-grained classification of the <a href="/Structure/cdd/cddsrv.cgi?uid=cl28910&spf=1">major facilitator superfamily</a> has also been added. You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.16"></A><B>CDD v3.16</B></P>
|
||
<P class="indent20 NormalText">[29 MAR 2017]  A new version of the <A HREF="/cdd/">Conserved Domain Database</A> has been released. Version 3.16 contains 1,659 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains, including models specifically built to annotate <A HREF="../cdd_help.shtml#RPSBStructuralMotifs">structural motifs</A> (<A HREF="../cdd_help.shtml#CDSource_accession_prefix">accession prefix</A> "sd"), and now mirrors <A HREF="http://pfam.xfam.org/">Pfam</A> version 30. A fine-grained classification of the 7-membrane GPCR transmembrane subunit has been added. In addition, the default database size parameters for CD-Search have been adjusted, resulting in slightly higher E-values. Fewer models are now assigned a multi-domain-model status, affecting the domain annotation of a large number of proteins. You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="/sparcle"><B>SPARCLE: Protein Classification</B></A></P>
|
||
<P class="indent20 NormalText">[12 OCT 2016]  The <A HREF="/sparcle"><B>Subfamily Protein Architecture Labeling Engine (SPARCLE)</B></A> is now available. It is a resource for the functional characterization and labeling of protein sequences that have been grouped by their characteristic domain architecture. To use SPARCLE, you can either: (1) <A HREF="/Structure/cdd/wrpsb.cgi">enter a query protein sequence into CD-Search</A>, which will display a "<B>Protein Classification</B>" on the results page if the query protein has a hit to a curated domain architecture in the SPARCLE database, or (2) <A HREF="/sparcle">search the SPARCLE database by keyword</A> to retrieve domain architectures that contain the term(s) of interest in their descriptions. With either approach, the corresponding SPARCLE record(s) will display the name and functional label of the architecture, supporting evidence, and links to other proteins with the same architecture. Additional information and illustrated examples are provided on the "<A HREF="/Structure/sparcle/docs/sparcle_about.html"><B>About SPARCLE</B></A>" page.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR -->
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="/sparcle"><B>SPARCLE: Protein Classification</B></A></P>
|
||
<P class="indent20 NormalText">[12 OCT 2016]  The <A HREF="/sparcle"><B>Subfamily Protein Architecture Labeling Engine (SPARCLE)</B></A> is now available. It is a resource for the functional characterization and labeling of protein sequences that have been grouped by their characteristic domain architecture. To use SPARCLE, you can either: (1) <A HREF="/Structure/cdd/wrpsb.cgi">enter a query protein sequence into CD-Search</A>, which will display a "<B>Protein Classification</B>" on the results page if the query protein has a hit to a curated domain architecture in the SPARCLE database, or (2) <A HREF="/sparcle">search the SPARCLE database by keyword</A> to retrieve domain architectures that contain the term(s) of interest in their descriptions. With either approach, the corresponding SPARCLE record(s) will display the name and functional label of the architecture, supporting evidence, and links to other proteins with the same architecture. Additional information and illustrated examples are provided on the "<A HREF="/Structure/sparcle/docs/sparcle_about.html"><B>About SPARCLE</B></A>" page.</P>
|
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|
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<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.15"></A><B>CDD v3.15</B></P>
|
||
<P class="indent20 NormalText">[27 JUN 2016]  A new version of the Conserved Domain Database has been released. Version 3.15 contains 290 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains, including models specifically built to annotate <A HREF="../cdd_help.shtml#RPSBStructuralMotifs">structural motifs</A> (<A HREF="../cdd_help.shtml#CDSource_accession_prefix">accession prefix</A> "sd"), and now mirrors <A HREF="http://pfam.xfam.org/">Pfam</A> version 28. A fine-grained classification of the beta lactamase-like metallohydrolases has been added. In addition, the default sort order of conserved domain hits in <A HREF="../wrpsb.cgi">CD Search</A> has been changed, ranking hits by <A HREF="../cdd_help.shtml#WRPSBExpect">E-value</A> without giving preference to NCBI-curated models.<!-- You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
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|
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|
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<P class="indent10bottomspace TOCText"><B>Updated version of the "rpsbproc" utility is now available</B></P>
|
||
<P class="indent20 NormalText">[29 JUN 2015]  An updated version of the "rpsbproc" command line utility for <A HREF="../cdd_help.shtml#RPSBWhat">RPS-BLAST</A> is now available from the CDD FTP site: <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd/rpsbproc/">//ftp.ncbi.nih.gov/pub/mmdb/cdd/rpsbproc/</A>. The output generated by the updated version includes a non-redundant list of <A HREF="../cdd_help.shtml#RPSBStructuralMotifs">structural motifs</A> (<A HREF="../cdd_help.shtml#CDSource_accession_prefix">accession prefix</A> "sd"), eliminating overlapping structural motifs. Additional information about the "rpsbproc" command line utility is provided in the <A HREF="#20141204_rpsbproc">December 4, 2014 announcement of its initial release</A>.</P>
|
||
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|
||
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|
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<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.14"></A><B>CDD v3.14</B></P>
|
||
<P class="indent20 NormalText">[28 MAY 2015]  A new version of the Conserved Domain Database has been released. Version 3.14 contains 560 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains, including models specifically built to annotate <A HREF="../cdd_help.shtml#RPSBStructuralMotifs">structural motifs</A> (<A HREF="../cdd_help.shtml#CDSource_accession_prefix">accession prefix</A> "sd"), and contains corrections to some short names for <A HREF="http://www.jcvi.org/cgi-bin/tigrfams/index.cgi">TIGRFAM</A> records as well as updated names and classifications for many models derived from <A HREF="/COG/">COGs</A>. A fine-grained classification of the Myosin motor domains has been added.<!-- You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
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|
||
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|
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|
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|
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|
||
|
||
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<P class="indent10bottomspace TOCText"><B>Improved consistency of domain annotation</B></P>
|
||
<P class="indent20 NormalText">[20 APR 2015]  The <A HREF="../wrpsb.cgi">CD-Search</A> service now offers two new options that are designed to improve the consistency of domain annotation, based on known domain architectures. The option to "<a href="../cdd_help.shtml#RescueBorderlineHits">Rescue Borderline Hits</a>" allows you to see hits that have an <a href="../cdd_help.shtml#WRPSBExpect">E-value</a> above the <a href="../cdd_help.shtml#RPSBWhat">RPS-BLAST</a> reporting threshold (anywhere between 0.01 and 1.0), and that are consistent with known domain architectures (<a href="../cdd_help.shtml#RescueBorderlineHitsIllustration">illustrated example</a>). The option to "<a href="../cdd_help.shtml#SuppressWeakOverlappingHits">Suppress Weak Overlapping Hits</a>" suppresses hits that have an E-value close to the RPS-BLAST reporting threshold (in between 0.01 and 0.001) but overlap with stronger hits (<a href="../cdd_help.shtml#SuppressWeakOverlappingHitsIllustration">illustrated example</a>). Additional details are provided in a publication by <A HREF="/pubmed/25767294?dopt=AbstractPlus">Derbyshire et al., 2015</A>.</P>
|
||
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|
||
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|
||
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||
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||
|
||
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||
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||
<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.13"></A><B>CDD v3.13</B></P>
|
||
<P class="indent20 NormalText">[09 JAN 2015]  A new version of the Conserved Domain Database has been released. Version 3.13 contains 286 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains, including models specifically built to annotate <A HREF="../cdd_help.shtml#RPSBStructuralMotifs">structural motifs</A> (<A HREF="../cdd_help.shtml#CDSource_accession_prefix">accession prefix</A> "sd"), and now mirrors <A HREF="http://www.jcvi.org/cgi-bin/tigrfams/index.cgi">TIGRFAMs</A> version 15.<!-- You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
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|
||
|
||
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||
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|
||
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|
||
|
||
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||
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|
||
<A NAME="20141204_rpsbproc"></A>
|
||
<P class="indent10bottomspace TOCText"><B>New post-processing utility is now available for RPS-BLAST</B></P>
|
||
<P class="indent20 NormalText">[04 DEC 2014]  A new "rpsbproc" command line utility is now available, as an addition to the standalone version of <A HREF="../cdd_help.shtml#RPSBWhat">Reverse Position-Specific BLAST (RPS-BLAST)</A>.<BR><BR>
|
||
|
||
Standalone RPS-BLAST ("rpsblast") continues to be packaged with the BLAST executables <A HREF="//ftp.ncbi.nih.gov/blast/executables/LATEST/">//ftp.ncbi.nih.gov/blast/executables/LATEST/</A>, as it has been since 2000. It lists the conserved domain models that score above a certain threshold (default set to an evalue of 10), sorted by scores, on each of your query protein sequences.<BR><BR>
|
||
|
||
The new "rpsbproc" utility is available from the CDD FTP site: <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd/rpsbproc/">//ftp.ncbi.nih.gov/pub/mmdb/cdd/rpsbproc/</A>. It post-processes the results of local RPS-BLAST searches in order to provide a non-redundant view of the conserved domains found in your protein query sequences, and to provide additional annotation on query sequences, such as domain superfamilies and conserved sites, similar to the annotation provided by the corresponding web services (e.g., the NCBI Batch CD-Search web service at <A HREF="/Structure/bwrpsb/bwrpsb.cgi">/Structure/bwrpsb/bwrpsb.cgi</A>). The <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd/rpsbproc/README">README</A> file provides additional details about the new "rpsbproc" utility.</P>
|
||
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|
||
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|
||
|
||
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||
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|
||
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|
||
|
||
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|
||
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|
||
<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.12"></A><B>CDD v3.12</B></P>
|
||
<P class="indent20 NormalText">[03 OCT 2014]  A new version of the Conserved Domain Database has been released. Version 3.12 contains 1526 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.<!-- You can access CDD at <A HREF="/cdd">/cdd</A> and find updated content on the CDD ftp site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
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|
||
|
||
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|
||
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|
||
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|
||
|
||
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|
||
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|
||
<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.11"></A><B>CDD v3.11</B></P>
|
||
<P class="indent20 NormalText">[15 FEB 2014]  A new version of the <A HREF="/cdd/">Conserved Domain Database (CDD)</A> has been released. Version 3.11 contains 596 new or updated NCBI-curated domain models and now contains the most recent <A HREF="http://pfam.xfam.org/">Pfam</A> release 27. Also, position-specific scoring matrices (<A HREF="../cdd_help.shtml#CD_PSSM">PSSM</A>s) have been re-computed for many models in CDD, and frequency tables have been added to the PSSMs. The search databases distributed as part of this release can now be used with the composition-based scoring that is now available in the more recent versions of <A HREF="../cdd_help.shtml#RPSBWhat">RPS-BLAST</A> (<A HREF="/books/NBK131777/#Blast_ReleaseNotes.BLAST_2228_March_19_2">version 2.2.28</A> and up). <!-- The latter abolishes the need to mask out compositionally biased regions in query sequences. -->The new search databases also remain compatible with previous versions of RPS-BLAST. <!-- Live and pre-computed searches available via the <A HREF="../wrpsb.cgi">CD-Search</A> web tool now use these settings, and as a result the domain annotations have changed for a number of protein sequences in Entrez. --><!-- The new search databases contain additional information that allow you to use them with the option for composition based scoring turned on in the new RPS-BLAST versions. These new search databases remain compatible with old versions of RPS-BLAST, and conversely, the old CDD search databases remain compatible with the new versions of RPS-BLAST. --><!-- You can access CDD from <A HREF="../cdd.shtml">/Structure/cdd/cdd.shtml</A> and find updated content on the CDD FTP site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. --><!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
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|
||
|
||
<TR>
|
||
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|
||
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|
||
|
||
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|
||
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|
||
<P class="indent10bottomspace TOCText"><B>CD-Search, Batch CD-Search, and CDART display style revised</B></P>
|
||
<P class="indent20 NormalText">[12 FEB 2014]  The display style for drawing domain models in <A HREF="../wrpsb.cgi">CD-Search</A>, <A HREF="../../bwrpsb/bwrpsb.cgi">Batch CD-Search</A>, and <A HREF="../../lexington/lexington.cgi">CDART</A> has been revised. The display style is now uniform among those tools, with a given domain model rendered in the same shape and color by all three tools<!-- with each interface using the same drawing style and color for a given domain model -->. Additionally, a new <A HREF="../cdd_help.shtml#RPSBResults">display option</A>, "<A HREF="../cdd_help.shtml#StandardDisplay">Standard Results</A>," is available in CD-Search and Batch CD-Search, and shows the top-scoring domain model from each source database. The Batch CD-Search <A HREF="../cdd_help.shtml#BatchRPSBOutputGraphical">graphical display</A> of search results also offers a new "<A HREF="../cdd_help.shtml#BatchRPSBOutputGraphicalNavigateResults">compact mode</A>," which displays the domain architecture of each query sequence on a single line. This display type is particularly useful if you select two or more query sequences from the list and want to compare their domain architectures. All three tools (CD-Search, Batch CD-Search, and CDART) employ the latest version of <A HREF="../cdd_help.shtml#RPSBWhat">RPS-BLAST</A>, which, as of <A HREF="/books/NBK131777/#Blast_ReleaseNotes.BLAST_2228_March_19_2">version 2.2.28</A>, uses composition-based scoring and abolishes the need to mask out compositionally biased regions in query sequences. Live and pre-computed searches generated by the CD-Search web tool now use these settings, and as a result the domain annotations have changed for a number of protein sequences in Entrez. <!--The search databases distributed as part of the CDD v3.11 release contain some additional information, relative to previous releases, that allow them to be used with this new version of RPS-BLAST, with the option for composition based scoring turned on. (These new search databases also remain compatible with old versions of RPS-BLAST. Conversely, the old CDD search databases remain compatible with the new versions of RPS-BLAST; they just can't be used with the option for composition based scoring.) --></P>
|
||
</TD>
|
||
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|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
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|
||
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|
||
<P class="indent10bottomspace TOCText"><A NAME="CDD_v3.10"></A><B>CDD v3.10</B></P>
|
||
<P class="indent20 NormalText">[21 MAR 2013]  A new version of the <A HREF="/cdd/">Conserved Domain Database (CDD)</A> has been released. Version 3.10 contains 1104 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domain models. Also, position-specific score matrices have been re-computed for a large fraction of the models in CDD, which has slightly affected the resulting sequence annotations. PSSMs are now provided in an extended format. They contain 28 rows instead of 26, and also come with intermediate data in addition to the final scoring matrix. The latter will make it possible to directly generate search databases for the current version of <A HREF="../cdd_help.shtml#RPSBWhat">RPS-BLAST</A>, <A HREF="/pubmed/22510480">DELTA-BLAST</A>, as well as an upcoming new version of RPS-BLAST that supports composition-corrected scoring.<!-- You can access CDD from <A HREF="cdd/cdd.shtml">/Structure/cdd/cdd.shtml</A> and find updated content on the CDD FTP site at <A HREF="//ftp.ncbi.nih.gov/pub/mmdb/cdd">//ftp.ncbi.nih.gov/pub/mmdb/cdd</A>. Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
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|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CD-Search "specific hits" now include domain models from external sources</B></P>
|
||
<P class="indent20 NormalText">[06 AUG 2012]  A <A HREF="../cdd_help.shtml#SpecificHit">specific hit</A> is a high confidence association between a protein query sequence and a conserved domain, resulting in a high confidence level for the inferred function of the protein query sequence. The algorithm for identifying specific hits has been revised to include domain models from external sources. Previously, specific hits were limited to <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains. Now, if domain models from both the NCBI-curated data set and <A HREF="../cdd_help.shtml#CDSource_external">external sources</A> meet a <A HREF="../cdd_help.shtml#SpecificHitThreshold">domain-specific threshold</A>, the NCBI-curated domain will still be listed preferentially as the specific hit because it has been annotated with fine-grained <A HREF="../cdd_help.shtml#PhylogeneticOrg">evolutionary relationships</A>, conserved sequence blocks, specific functions, and <A HREF="../cdd_help.shtml#ConservedFeatures">conserved features/sites</A> based on careful review of <A HREF="../cdd_help.shtml#CDModel">sequence data</A>, <A HREF="../cdd_help.shtml#Include3DStruct">3D structures</A>, and <A HREF="../cdd_help.shtml#ElectronicLiterature">literature</A>. <!-- NCBI-curated domains are also annotated with <A HREF="../cdd_help.shtml#ConservedFeatures">conserved features</A>, noting the specific residues within the domain that are involved in catalysis or binding. -->However, if no NCBI-curated domain meets the criteria for a specific hit, then the top-ranked domain model from an external source will be shown in the CD-Search results <A HREF="../cdd_help.shtml#ConciseDisplay">concise display</A> if it meets all the criteria for a specific hit. As a result of this change, more sequences in the Entrez Protein database are now annotated with specific functional information.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.09</B></P>
|
||
<P class="indent20 NormalText">[01 NOV 2012]  The CDD v3.09 release includes 42 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains and now mirrors <A HREF="http://www.jcvi.org/cgi-bin/tigrfams/index.cgi">TIGRFAM</A> v13.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.08</B></P>
|
||
<P class="indent20 NormalText">[17 SEP 2012]  The CDD v3.08 release includes 239 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.07</B></P>
|
||
<P class="indent20 NormalText">[06 AUG 2012]  The CDD v3.07 release includes 495 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.06</B></P>
|
||
<P class="indent20 NormalText">[29 MAY 2012]  The CDD v3.06 release includes 310 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
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|
||
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|
||
<P class="indent10bottomspace TOCText"><B>Conserved Domain searches now launched for blastx queries</B></P>
|
||
<P class="indent20 NormalText">[28 MAR 2012]  Conserved Domain searches are now being launched for all nucleotide queries shorter than 10,000 base pairs submitted to <A HREF="https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastx&BLAST_PROGRAMS=blastx&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome">blastx</A>, the <A HREF="https://blast.ncbi.nlm.nih.gov/">BLAST</A> program that translates a nucleotide query sequence in six reading frames and compares each translation against the protein data set. The blastx search results page includes a <A HREF="../cdd_help.shtml#ConciseDisplay">concise display</A> of the conserved domains found on the translated reading frames, and that graphic links to the corresponding interactive view in the CD-Search tool.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.05</B></P>
|
||
<P class="indent20 NormalText">[23 MAR 2012]  The CDD v3.05 release includes 161 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domain models and now mirrors <A HREF="http://www.jcvi.org/cgi-bin/tigrfams/index.cgi">TIGRFAM</A> v12.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.04</B></P>
|
||
<P class="indent20 NormalText">[08 MAR 2012]  The CDD v3.04 release includes 166 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domain models.</A>.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.03</B></P>
|
||
<P class="indent20 NormalText">[19 JAN 2012]  The CDD v3.03 release includes 174 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domain models and now mirrors <A HREF="http://pfam.xfam.org/">PFAM</A> v26. <!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.02</B></P>
|
||
<P class="indent20 NormalText">[07 DEC 2011]  The CDD v3.02 release includes 170 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domain models and now mirrors <A HREF="http://www.jcvi.org/cgi-bin/tigrfams/index.cgi">TIGRFAM</A> v11.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.01</B></P>
|
||
<P class="indent20 NormalText">[09 NOV 2011]  The CDD v3.01 release includes 298 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> 
|
||
<BR></TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CD-Search now accepts nucleotide sequences as queries</B></P>
|
||
<P class="indent20 NormalText">[04 NOV 2011]  The <A HREF="/Structure/cdd/wrpsb.cgi">CD-Search</A> tool now accepts nucleotide sequences as queries. It translates them in all six reading frames and searches each protein product against the <A HREF="../cdd_help.shtml#RPSBWhat">RPS-BLAST</A> databases. CD-Search will combine the results for all the proteins into a single page, but will only display the translated reading frames that picked up a match in CDD. The help document provides <A HREF="../cdd_help.shtml#QuerySequence">additional details</A>.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v3.00</B></P>
|
||
<P class="indent20 NormalText">[28 Oct 2011]  The CDD v3.00 release contains the same conserved domain models as the previous release (CDD v2.32). However, the composition of some <A HREF="../cdd_help.shtml#Superfamily">superfamily</A> clusters have changed, and the single domain/<A HREF="../cdd_help.shtml#RPSB_hit_type_multi_domain">multidomain</A> status assigned to some conserved domain models has also changed. These changes are due to a slightly revised E-value calculation implemented in the BLAST program suite (including <A HREF="../cdd_help.shtml#RPSBWhat">RPS-BLAST</A>), which now uses a new variant of the Finite Size Correction that produces more accurate E-values for short query and/or subject sequences.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> 
|
||
<BR></TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="../../cdtree/shtml"><B>CDTree</B></A> <B>now includes the latest version of</B> <A HREF="../../CN3D/cn3d.shtml"><B>Cn3D</B></A></P>
|
||
<P class="indent20 NormalText">[18 OCT 2011]  A new <A HREF="../../cdtree/cdtree.shtml"><B>CDTree</B></A> software bundle is now available and includes the most recent version of NCBI's 3D structure viewing program, <A HREF="../../CN3D/cn3d.shtml">Cn3D 4.3</A>. CDTree is:
|
||
<UL>
|
||
<LI>a powerful tool to aid in the classification of protein sequences and investigate their evolutionary relationships</LI>
|
||
<LI>a web-based helper application used by the CDD on-line search service to permit user interaction with pre-defined protein domain hierarchies</LI>
|
||
<LI>an integrated software environment organized to help users assimilate large amounts of biological data from various resources by access to a suite of analysis methods</LI>
|
||
<LI>an alignment editor and 3D structure visualization program through its integration with Cn3D 4.3</LI>
|
||
</UL>
|
||
</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell MicroText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<A NAME="NewCDARTversion"></A>
|
||
<P class="indent10bottomspace TOCText"><B>New version of</B> <A HREF="../../lexington/lexington.cgi"><B>CDART</B></A> <B>offers new functions & features</B></P>
|
||
<P class="indent20 NormalText">[05 OCT 2011]  A new release of the <A HREF="../../lexington/lexington.cgi"><B>C</B>onserved <B>D</B>omain <B>A</B>rchitecture <B>R</B>etrieval <B>T</B>ool (CDART)</A> is available and offers new functions and features for finding proteins that have <A HREF="../../lexington/docs/cdart_help.html#DomainArchitectureDefinition">domain architectures</A> similar to a query protein (<A HREF="../../lexington/docs/cdart_about.html">illustrated example</A>):
|
||
|
||
<UL>
|
||
<LI>reengineered for improved performance with long query proteins and complicated domain architectures</LI>
|
||
<LI>expanded <A HREF="../../lexington/docs/cdart_help.html#Input">input options</A> now allow you to enter a query as:</LI>
|
||
<UL>
|
||
<LI><A HREF="../../lexington/docs/cdart_help.html#InputProtein">protein sequence</A></LI>
|
||
<LI><A HREF="../../lexington/docs/cdart_help.html#InputConservedDomainSet">set of conserved domains</A></LI>
|
||
<LI><A HREF="../../lexington/docs/cdart_help.html#InputMultipleQueries">multiple queries</A></LI>
|
||
</UL>
|
||
<LI><A HREF="../../lexington/docs/cdart_help.html#OutputDomainArchitectureSimilarityScore">similarity scores</A> are now displayed in search results for more transparent ranking/sorting</LI>
|
||
<LI>new options to <A HREF="../../lexington/docs/cdart_help.html#OutputFilters">filter your results</A> include the ability to include/exclude proteins from specific organisms and/or proteins that contain specific conserved domains, and to combine the filters with Boolean logic.</LI>
|
||
<LI><A HREF="../../lexington/lexington.cgi">try a search</A> with your favorite protein!</LI>
|
||
</UL>
|
||
</P>
|
||
|
||
<!-- P class="indent20"><A HREF="../../lexington/docs/cdart_help.html"><IMG src="images/np_081086_cdart_thumbnail_wide.png" width="340" height="213" border=0 align="left" alt="Thumbnail image showing the domain relatives for a protein query sequence (NP_081086, mouse DNA mismatch repair protein Mlh1). Domain relatives are protein sequences that contain one or more of the conserved domains found in the query sequence. Click on the image to open the CDART help document for more information about the tool."></A><IMG SRC="../../IMG/spacer.gif" width="5" height="213" border="0" align="left" -->
|
||
</P>
|
||
|
||
</TD>
|
||
</TR>
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR -->
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.32</B></P>
|
||
<P class="indent20 NormalText">[02 SEP 2011]  The CDD v2.32 release includes 14 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains, suppresses pfam10695, and fixes errors in superfamily clustering.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="/cdd/"><B>Entrez CDD</B></A> <B>interface redesign</B></P>
|
||
<P class="indent20 NormalText">
|
||
<!-- A HREF="/cdd/"><IMG SRC="images/entrez3_home_page_cdd.png" WIDTH="400" HEIGHT="280" BORDER="1" ALIGN="right" ALT="Thumbnail image of the newly released Entrez Conserved Domain Database (CDD) home page. Click on the image to open the live database home page."></A -->
|
||
[25 JULY 2011]  The <A HREF="/cdd/">Conserved Domain Database</A> now has a revised home page, search interface, and search results display, to have functions similar to those available in PubMed. Changes include: (a) a streamlined home page with links to related resources; (b) an "Advanced Search" page, which provides the ability to build a query one term at a time, browse the index of any search field, and combine earlier searches<!--, functions previously available in the "Preview/Index" and "History" folder tabs of the earlier interface -->; and (c) new search results displays that provide links in the right margin to search filters, related data, and tools.
|
||
</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.31</B></P>
|
||
<P class="indent20 NormalText">[19 AUG 2011]  The CDD v2.31 release includes 292 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains and now mirrors <A HREF="http://smart.embl-heidelberg.de/">SMART</A> v6.0.<!-- Click on the database statistics at the right to retrieve the subset of records from any <A HREF="../cdd_help.shtml#CDSource">source database</A>. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.30</B></P>
|
||
<P class="indent20 NormalText">[16 JUN 2011]  The CDD v2.30 release includes 201 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.29</B></P>
|
||
<P class="indent20 NormalText">[13 MAY 2011]  The CDD v2.29 release includes 256 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains, and now mirrors <A HREF="http://www.jcvi.org/cgi-bin/tigrfams/index.cgi">TIGRFAM</A> v10.1 and <A HREF="http://pfam.xfam.org/">Pfam</A> v25.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.28</B></P>
|
||
<P class="indent20 NormalText">[30 MAR 2011]  The CDD v2.28 release includes 611 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains and now mirrors <A HREF="http://www.jcvi.org/cgi-bin/tigrfams/index.cgi">TIGRFAM</A> v10.<!-- Click on the database statistic at the right beside "NCBI CDD curation effort" to retrieve all NCBI-curated records, including recently updated and recently released domain models. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.27</B></P>
|
||
<P class="indent20 NormalText">[02 MAR 2011]  The CDD v2.27 release includes 357 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.<!-- Click on the database statistic at the right beside "NCBI CDD curation effort" to retrieve all NCBI-curated records, including recently updated and recently released domain models. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.26</B></P>
|
||
<P class="indent20 NormalText">[29 DEC 2010]  The CDD v2.26 release includes 124 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains as well as the most recent data from <A HREF="/proteinclusters/">PRK</A>.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.25</B></P>
|
||
<P class="indent20 NormalText">[07 OCT 2010]  The CDD v2.25 release includes 88 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="/Structure/bwrpsb/bwrpsb.cgi"><B>Batch CD-Search</B></A></P>
|
||
<P class="indent20 NormalText">[30 SEP 2010]   A <A HREF="/Structure/bwrpsb/bwrpsb.cgi">Batch CD-Search</A> tool is now available for the computation and download of <!-- A HREF="../cdd_help.shtml#CDWhat" -->conserved domain annotation on large sets of protein queries. <A HREF="../cdd_help.shtml#BatchRPSBInput">Input</A> up to 100,000 protein query sequences as a list of sequence identifiers and/or raw sequence data, then download <A HREF="../cdd_help.shtml#BatchRPSBOutput">output</A> in a variety of formats (including tab-delimited text files) or <A HREF="../cdd_help.shtml#BatchRPSBOutputGraphical">view the search results graphically</A>. See the <A HREF="../cdd_help.shtml#TOC_BatchCDSearch">help document</A> for additional details, including information on using Batch CD-Search for <A HREF="../cdd_help.shtml#BatchRPSBWebAPI">scripted data downloads</A>.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.24</B></P>
|
||
<P class="indent20 NormalText">[09 SEP 2010]  The CDD v2.24 release includes 196 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.<!-- Click on the database statistic at the right beside "NCBI CDD curation effort" to retrieve all NCBI-curated records, including recently updated and recently released domain models. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.23</B></P>
|
||
<P class="indent20 NormalText">[29 JUL 2010]  The CDD v2.23 release includes 174 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.<!-- Click on the database statistic at the right beside "NCBI CDD curation effort" to retrieve all NCBI-curated records, including recently updated and recently released domain models. --></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.22</B></P>
|
||
<P class="indent20 NormalText">[26 MAY 2010]  The CDD v2.22 release includes 443 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.21</B></P>
|
||
<P class="indent20 NormalText">[13 APR 2010]  The CDD v2.21 release includes 489 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains as well as the most recent data from <A HREF="/proteinclusters/">PRK</A>, which now includes domain models for plant-specific (non-chloropast) proteins, indicated by PLN <A HREF="../cdd_help.shtml#CDSource_accession_prefix">accession number prefixes</A>.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.20</B></P>
|
||
<P class="indent20 NormalText">[19 MAR 2010]  The CDD v2.20 release includes 107 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains, and now mirrors <A HREF="http://www.jcvi.org/cms/research/projects/tigrfams/overview/">TIGRFAM</A> v9.0.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.19</B></P>
|
||
<P class="indent20 NormalText">[01 FEB 2010]  The CDD v2.19 release includes <A HREF="http://pfam.xfam.org/">PFAM</A> v24.0 as well as 532 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.18</B></P>
|
||
<P class="indent20 NormalText">[10 DEC 2009]  The CDD v2.18 release includes 489 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><B>CDD v2.17</B></P>
|
||
<P class="indent20 NormalText">[04 JUN 2009]  The CDD v2.17 release includes 484 new or updated <A HREF="../cdd_help.shtml#CDSource_NCBI_curated">NCBI-curated</A> domains, as well as records from a new <A HREF="../cdd_help.shtml#CDSource">data source</A>, <A HREF="http://www.jcvi.org/cms/research/projects/tigrfams/overview/">TIGRFAM</A>, and protozoan domains from the <A HREF="/proteinclusters/">Protein Clusters (PRK)</A> database.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<!-- A HREF="#Top"><img SRC="../../IMG/arrowup_blue.gif" width="12" height="12" border="0" align="right" valign="top" alt="back to top"></IMG></A -->
|
||
<P class="indent10bottomspace TOCText"><A HREF="../cdd_help.shtml#SpecificHit"><B>Specific Hits</B></A></P>
|
||
<P class="indent20 NormalText">[08 MAY 2008]  The <A HREF="/Structure/cdd/wrpsb.cgi">CD-Search</A> tool now shows four types of hits in <A HREF="../cdd_help.shtml#RPSBResults">search results</A>, including <A HREF="../cdd_help.shtml#SpecificHit">specific hits</A>. A specific hit is a high confidence association between a protein query sequence and a conserved domain, resulting in a high confidence level for the inferred function of the protein query sequence. <A HREF="../cdd_help.shtml#SpecificHit">more...</A></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="../cdd_help.shtml#Superfamily"><B>Superfamilies</B></A></P>
|
||
<P class="indent20 NormalText">[08 MAY 2008]  The Conserved Domain Database (CDD) is now organized into <A HREF="../cdd_help.shtml#Superfamily">superfamilies</A>. A superfamily cluster is a set of conserved domain models that generate overlapping annotation on the same protein sequences. These models are assumed to represent evolutionarily related domains and may be redundant with each other. <A HREF="../cdd_help.shtml#Superfamily">more...</A></P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
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|
||
|
||
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|
||
<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<!-- ==================== END_2008_NEWS ==================== -->
|
||
|
||
<!-- ==================== 2007_HEADER ==================== -->
|
||
|
||
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|
||
<TD class="WhiteCell" ALIGN="LEFT" VALIGN="TOP">
|
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|
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|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP">
|
||
<A NAME="_____"><B>2007</B></A>
|
||
</TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"><A HREF="#Top"><img SRC="../../IMG/arrowup_blue.gif" width="12" height="12" border="0" alt="back to top"></A></TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP"><HR></TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"> </TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
</TABLE>
|
||
</TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_2007_HEADER ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="#___"><B>Header (e.g., specific hits)</B></A></P>
|
||
<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="#___"><B>Header (e.g., superfamilies)</B></A></P>
|
||
<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_2007_NEWS ==================== -->
|
||
|
||
<!-- ==================== 2006_HEADER ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell" ALIGN="LEFT" VALIGN="TOP">
|
||
<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" class="WhiteCell TOCText2">
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP">
|
||
<A NAME="_____"><B>2006</B></A>
|
||
</TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"><A HREF="#Top"><img SRC="../../IMG/arrowup_blue.gif" width="12" height="12" border="0" alt="back to top"></A></TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP"><HR></TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"> </TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
</TABLE>
|
||
</TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_2006_HEADER ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="#___"><B>Header (e.g., specific hits)</B></A></P>
|
||
<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="#___"><B>Header (e.g., superfamilies)</B></A></P>
|
||
<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_2006_NEWS ==================== -->
|
||
|
||
<!-- ==================== 20XX_HEADER ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell" ALIGN="LEFT" VALIGN="TOP">
|
||
<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" class="WhiteCell TOCText2">
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP">
|
||
<A NAME="_____"><B>20XX</B></A>
|
||
</TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"><A HREF="#Top"><img SRC="../../IMG/arrowup_blue.gif" width="12" height="12" border="0" alt="back to top"></A></TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell" WIDTH="20" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="100" ALIGN="LEFT" VALIGN="TOP"><HR></TD>
|
||
<TD class="WhiteCell" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
<TD class="WhiteCell" WIDTH="15" ALIGN="left" VALIGN="center"> </TD>
|
||
<TD class="WhiteCell" WIDTH="5" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
</TABLE>
|
||
</TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_20XX_HEADER ==================== -->
|
||
|
||
<!-- TR>
|
||
<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="#___"><B>Header (e.g., specific hits)</B></A></P>
|
||
<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
|
||
<P class="indent10bottomspace TOCText"><A HREF="#___"><B>Header (e.g., superfamilies)</B></A></P>
|
||
<P class="indent20 NormalText">[DD-MMM-YYYY]  Brief description of new database feature with <A HREF="#___">link</A> to detailed information in help doc. Text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
|
||
</TD>
|
||
</TR>
|
||
|
||
<TR>
|
||
<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> <BR><BR></TD>
|
||
</TR -->
|
||
|
||
<!-- ==================== END_20XX_NEWS ==================== -->
|
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||
</TABLE>
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<!-- ==================== END_BOX3_NEWS_ARCHIVE ====================== -->
|
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</TD>
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<!-- ============ VERTICAL_SPACER_WITHIN_CONTENT_AREA ============= -->
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<TABLE width="100%" border="0" cellspacing="0" cellpadding="0">
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<!-- ############ END_BLUE_EDGE_BOX_WITH_TITLE_OF_DOCUMENT_AND_TOC ######## -->
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<!-- ==================== VERTICAL SPACER ======================= -->
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<TABLE width="100%" border="0" cellspacing="0" cellpadding="0">
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<TD class="WhiteCell NormalText"> </TD>
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0">
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<TR>
|
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<TD VALIGN="top" ALIGN="RIGHT"><SPAN CLASS="HELPBAR1"> <SPAN style="color:#646464">Revised 21 September 2022</SPAN></SPAN></TD>
|
||
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