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<meta name="description" content="In October 2018, NCATS, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and the Center for the Advancement of Science in Space announced four two-year awards for approximately $4.98 million to use tissue chip technology to better understand the mechanisms of disease and the effectiveness of potential treatments in the extreme environment of space." />
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<div class="contact-box"><h4>Contact</h4><p><a href="mailto:Danilo.Tagle@nih.gov?subject=Tissue%20Chip%20program%20inquiry" target="_blank" title="Email Danilo Tagle">Danilo Tagle, Ph.D.</a></p></div><p>In October 2018, NCATS, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and the Center for the Advancement of Science in Space <a href="https://www.issnationallab.org/series-of-human-physiology-projects-selected-by-ncats-nibib-for-international-space-station-research/" title="Series of Human Physiology Projects Selected by NCATS, NIBIB for International Space Station Research" target="_blank">announced four two-year awards</a> for approximately $4.98 million to use tissue chip technology to better understand the mechanisms of disease and the effectiveness of potential treatments in the extreme environment of space. The projects are part of a collaboration to conduct translational research on board the International Space Station U.S. National Laboratory.</p><p>Learn more about the projects awarded in 2018:</p><div class="field-body"><h3>Emulate, Inc., Boston</h3><h4 id="organ-chips"><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9645490&icde=41440219&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=">Organ-Chips as a Platform for Studying Effects of Space on Human Enteric Physiology: Interactions of Epithelial Mucosa with Sensory Neurons and Microbiome</a></h4><p><strong>Principal Investigators:</strong> Christopher D. Hinojosa, M.S., and Katia Karalis, M.D., Ph.D. <br><strong>Implementation Partner:</strong> <a class="ext" href="http://www.spacetango.com/" target="_blank" title="Space Tango">Space Tango</a> <br><strong>Grant Number:</strong> 1-UG3-TR-002595-01</p><p><strong>First Flight</strong>: March 6, 2020</p><h3>University of Florida, Gainesville</h3><h4 id="electrical-stimulation"><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9645400&icde=41440163&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=">Electrical Stimulation of Human Myocytes in Microgravity: An <em>In Vitro</em> Model to Evaluate Therapeutics to Counteract Muscle Wasting</a></h4><p><strong>Principal Investigator:</strong> Siobhan Malany, Ph.D. <br><strong>Implementation Partner:</strong> <a class="ext" href="http://www.spacetango.com/" target="_blank" title="Space Tango">Space Tango</a> <br><strong>Grant Number:</strong> 1-UG3-TR-002598-01</p><p><strong>First Flight:</strong> Dec. 6, 2020 <br><strong>Second Flight:</strong> July 14, 2022</p><h3>Stanford University, Stanford, California</h3><h4 id="microgravity"><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9644885&icde=41440096&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=">Effect of Microgravity on Drug Responses Using Engineered Heart Tissues</a></h4><p><strong>Principal Investigators:</strong> Joseph C. Wu, M.D., Ph.D., and Beth L. Pruitt, Ph.D., M.Sc. <br><strong>Implementation Partner:</strong> <a class="ext" href="https://www.colorado.edu/engineering/BioServe/" target="_blank" title="University of Colorado, Boulder BioServe Space Technologies">BioServe Space Technologies at the University of Colorado, Boulder</a> <br><strong>Grant Number:</strong> 1-UG3-TR-002588-01</p><p><strong>First Flight</strong>: Dec. 6, 2020</p><h3>University of Washington, Seattle and Johns Hopkins University</h3><h4 id="human-ipsc-based"><a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9644709&icde=41439964">A Human iPSC-Based 3-D Microphysiological System for Modeling Cardiac Dysfunction in Microgravity*</a></h4><p><strong>Principal Investigator:</strong> Deok-Ho Kim, Ph.D., M.S. <br><strong>Implementation Partners:</strong> The Ohio State University and <a class="ext" href="https://www.colorado.edu/engineering/BioServe/" target="_blank" title="University of Colorado, Boulder BioServe Space Technologies">BioServe Space Technologies at the University of Colorado, Boulder</a> <br><strong>Grant Number:</strong> 1-UG3-EB-028094-01</p><p><strong>First Flight</strong>: March 6, 2020</p><p><em>*Funded by NIH’s NIBIB and NCATS.</em></p></div>
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