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<span>Is temperament determined by genetics?</span>
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<h1>Is temperament determined by genetics?</h1>
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<section><div class="mp-content"><p>Temperament includes behavioral traits such as sociability (outgoing or shy), emotionality (easy-going or quick to react), activity level (high or low energy), attention level (focused or easily distracted), and persistence (determined or easily discouraged). These examples represent a spectrum of common characteristics, each of which may be advantageous in certain circumstances. Temperament remains fairly consistent, particularly throughout adulthood.</p>
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<p>Similar temperaments within a family may be attributable to shared genetics and to the environment in which an individual is raised. Studies of identical twins (who share 100 percent of their DNA) and their non-twin siblings (who share about 50 percent of their DNA) show that genetics play a large role. Identical twins typically have very similar temperaments when compared with their other siblings. Even identical twins who were raised apart from one another in separate households share such traits.</p>
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<p>Scientists estimate that 20 to 60 percent of temperament is determined by genetics. Temperament, however, does not have a clear pattern of inheritance and there are not specific genes that confer specific temperamental traits. Instead, many (perhaps thousands) of common gene variations (polymorphisms) combine to influence individual characteristics of temperament. Other DNA modifications that do not alter DNA sequences (<a data-pid="20151" href="https://medlineplus.gov/genetics/understanding/howgeneswork/epigenome/">epigenetic changes</a>) also likely contribute to temperament.</p>
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<p>Large studies have identified several genes that play a role in temperament. Many of these genes are involved in communication between cells in the brain. Certain gene variations may contribute to particular traits related to temperament. For example, variants in the <em>DRD2</em> and <em>DRD4 </em>genes have been linked to a desire to seek out new experiences, and <em>KATNAL2 </em>gene variants are associated with self-discipline and carefulness. Variants affecting the <em>PCDH15</em> and <em>WSCD2 </em>genes are associated with sociability, while some<em> </em><a data-pid="19811" href="https://medlineplus.gov/genetics/gene/maoa/"><em>MAOA</em> </a>gene variants may be linked to introversion, particularly in certain environments. Variants in several genes, such as <em>SLC6A4</em>, <em>AGBL2</em>, <em>BAIAP2</em>, <em>CELF4</em>, <em>L3MBTL2</em>, <em>LINGO2</em>, <em>XKR6</em>, <em>ZC3H7B</em>, <em>OLFM4</em>, <em>MEF2C</em>, and <em>TMEM161B </em>contribute to anxiousness or <a data-pid="16877" href="https://medlineplus.gov/genetics/condition/depression/">depression</a>.</p>
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<p>Environmental factors also play a role in temperament by influencing gene activity. In children raised in an adverse environment (such as one of child abuse and violence), genes that increase the risk of impulsive temperamental characteristics may be turned on (activated). However, a child who grows up in a positive environment (for example a safe and loving home) may have a calmer temperament, in part because a different set of genes is activated</p>
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<h2>Scientific journal articles for further reading</h2>
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<p>Bratko D, Butković A, Vukasović T. <a href="https://bib.irb.hr/datoteka/876456.Bratko_Butkovic_Vukasovic_Hlupic_2017.PDF" target="_blank">Heritability of personality</a>. Psychological Topics, 26 (2017), 1, 1-24.</p>
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<p>Manuck SB, McCaffery JM. Gene-environment interaction. Annu Rev Psychol. 2014;65:41-70. doi: 10.1146/annurev-psych-010213-115100. PubMed: <a href="https://www.ncbi.nlm.nih.gov/pubmed/24405358" target="_blank">24405358</a>
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<p>Power RA, Pluess M. Heritability estimates of the big five personality traits based on common genetic variants. Translational Psychiatry (2015) 5, e604; doi:10.1038/tp.2015.96; published online 14 July 2015. PubMed: <a href="https://www.ncbi.nlm.nih.gov/pubmed/26171985" target="_blank">26171985</a> PubMed Central: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068715/" target="_blank">PMC5068715</a>
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<section><div class="mp-exp mp-content"><h2>Topics in the Genetics and Human Traits chapter</h2><ul><li><a data-pid="20179" href="https://medlineplus.gov/genetics/understanding/traits/fingerprints/">Are fingerprints determined by genetics?</a></li><li><a data-pid="20181" href="https://medlineplus.gov/genetics/understanding/traits/eyecolor/">Is eye color determined by genetics?</a></li><li><a data-pid="20183" href="https://medlineplus.gov/genetics/understanding/traits/intelligence/">Is intelligence determined by genetics?</a></li><li><a data-pid="20185" href="https://medlineplus.gov/genetics/understanding/traits/handedness/">Is handedness determined by genetics?</a></li><li><a data-pid="20187" href="https://medlineplus.gov/genetics/understanding/traits/twins/">Is the probability of having twins determined by genetics?</a></li><li><a data-pid="20189" href="https://medlineplus.gov/genetics/understanding/traits/hairtexture/">Is hair texture determined by genetics?</a></li><li><a data-pid="20191" href="https://medlineplus.gov/genetics/understanding/traits/haircolor/">Is hair color determined by genetics?</a></li><li><a data-pid="20193" href="https://medlineplus.gov/genetics/understanding/traits/height/">Is height determined by genetics?</a></li><li><a data-pid="20195" href="https://medlineplus.gov/genetics/understanding/traits/moles/">Are moles determined by genetics?</a></li><li><a data-pid="20197" href="https://medlineplus.gov/genetics/understanding/traits/dimples/">Are facial dimples determined by genetics?</a></li><li><a data-pid="20199" href="https://medlineplus.gov/genetics/understanding/traits/athleticperformance/">Is athletic performance determined by genetics?</a></li><li><a data-pid="20201" href="https://medlineplus.gov/genetics/understanding/traits/longevity/">Is longevity determined by genetics?</a></li><li>Is temperament determined by genetics?</li></ul><p><a data-pid="20081" href="https://medlineplus.gov/genetics/understanding/">Other chapters in Help Me Understand Genetics</a></p></div>
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