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<span>What is genetic ancestry testing?</span>
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<h1>What is genetic ancestry testing?</h1>
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<section><div class="mp-content"><p>Genetic ancestry testing, or genetic genealogy, is a way for people interested in <a data-pid="20161" href="https://medlineplus.gov/genetics/understanding/inheritance/familyhistory/">family history</a> (genealogy) to go beyond what they can learn from relatives or from historical documentation. Examination of DNA variations can provide clues about where a person's ancestors might have come from and about relationships between families. Certain patterns of genetic variation are often shared among people of particular backgrounds. The more closely related two individuals, families, or populations are, the more patterns of variation they typically share.</p>
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<p>Three types of genetic ancestry testing are commonly used for genealogy:</p>
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<h2><a data-pid="20077" href="https://medlineplus.gov/genetics/chromosome/y/">Y chromosome</a> testing</h2>
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<p>Variations in the Y chromosome can be used to explore ancestry in the direct male line. Only individuals with a Y chromosome (typically males) can have this type of testing done. However, people interested in this type of genetic testing sometimes recruit a relative to have the test done. Because the Y chromosome is passed on in the same pattern as are family names (surnames) in many cultures, Y chromosome testing is often used to investigate questions such as whether two families with the same surname are related.</p>
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<h2><a data-pid="20079" href="https://medlineplus.gov/genetics/chromosome/mitochondrial-dna/">Mitochondrial DNA</a> testing</h2>
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<p>This type of testing identifies genetic variations in mitochondrial DNA. Although most DNA is packaged in chromosomes within the cell nucleus, cell structures called <a class="image-modal" data-alt="Mitochondrial DNA is the small circular chromosome found inside mitochondria." data-caption="Mitochondrial DNA is the small circular chromosome found inside mitochondria. The mitochondria are organelles found in cells that are the sites of energy production. The mitochondria, and thus mitochondrial DNA, are passed from mother to offspring." data-credit="Darryl Leja, NHGRI" data-filepath="images/PX0000HG_PRESENTATION.jpeg" data-imgtype="genetics" data-lang="us" data-pix="PX0000HG" data-sourceurl="" data-title="Mitochondrial DNA" href="https://medlineplus.gov/images/PX0000HG_PRESENTATION.jpeg" id="PX0000HG_4" title="Show image">mitochondria<img alt="" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> also have a small amount of their own DNA (known as mitochondrial DNA). Both males and females have mitochondrial DNA so this type of testing can be used by either sex. Mitochondria DNA is passed on solely from egg cells so it provides information about the direct female ancestral line. Mitochondrial DNA testing can be useful for genealogy because it preserves information about female ancestors that may be lost from the historical record because of the way surnames are often passed down.</p>
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<h2><a data-pid="20295" href="https://medlineplus.gov/genetics/understanding/genomicresearch/snp/">Single nucleotide polymorphism</a> testing</h2>
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<p>These tests evaluate large numbers of individual variations (single nucleotide polymorphisms or SNPs) across a person’s entire genome. The results are compared to similar SNPs in a testing database to provide an estimate of a person's ethnic background. For example, the pattern of SNPs might indicate that a person's ancestry is approximately 50 percent African, 25 percent European, 20 percent Asian, and 5 percent unknown. (Sometimes, more regional specificity can be provided.) Genealogists use this type of test because Y chromosome and mitochondrial DNA test results, which represent only single ancestral lines, do not capture the overall ancestral background of an individual.</p>
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<p>Genetic ancestry testing has a number of limitations. Test providers compare individuals' test results to different databases of SNPs, so ethnicity estimates may not be consistent from one provider to another. Additionally, these databases do not have equal coverage of SNPs for all ethnic populations; so results for minority populations may be nonspecific or inaccurate. Also, because most human populations have migrated many times throughout their history and mixed with nearby groups, ethnicity estimates based on genetic testing may differ from an individual's expectations. In <a data-pid="20175" href="https://medlineplus.gov/genetics/understanding/inheritance/ethnicgroup/">ethnic groups</a> with a smaller range of genetic variation due to the group's size and history, most members share many SNPs, and it may be difficult to distinguish people who have a relatively recent common ancestor, such as fourth cousins, from the group as a whole.</p>
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<p>Genetic ancestry testing is offered by several companies and organizations. Most companies provide online forums and other services to allow people who have been tested to share and discuss their results with others, which may allow them to discover previously unknown relationships. On a larger scale, combined genetic ancestry test results from many people can be used by scientists to explore the history of populations as they arose, migrated, and mixed with other groups.</p></div>
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<h2>For more information about genetic ancestry testing:</h2>
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<p>The University of Utah provides <a href="https://learn.genetics.utah.edu/content/basics/molgen/" target="_blank">video tutorials</a> on molecular genealogy.</p>
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<p>
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<a href="https://isogg.org/" target="_blank">The International Society of Genetic Genealogy</a> promotes the use of DNA testing in genealogy.</p>
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<p>The National Human Genome Research Institute discusses <a href="https://www.genome.gov/dna-day/15-ways/human-origins-ancestry" target="_blank">human origins and ancestry</a>.<span class="desc-text"><img alt="From the National Institutes of Health" class="imgdesc" height="16" src="https://medlineplus.gov/images/nih.png" title="From the National Institutes of Health" width="25"/></span></p>
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<p>The Tech Interactive provides information about <a href="https://thetech.org/ask-a-geneticist/how-ancestry-tests-work" target="_blank">how ancestry testing works</a>.</p>
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<p>The Smithsonian National Museum of Natural History's exhibit 'Genome: Unlocking Life's Code' discusses <a href="https://www.unlockinglifescode.org/genomics-insights/ancestry-vs-race-implications-society">the difference between ancestry and race</a>. The exhibit also discusses the <a href="https://www.unlockinglifescode.org/genomics-insights/hominid-development-great-human-migration-and-concept-race">Great Human Migration</a> and its influence on heredity and genealogy.</p>
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<section><div class="mp-exp mp-content"><h2>Topics in the Direct-to-Consumer Genetic Testing chapter</h2><ul><li><a data-pid="20253" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/directtoconsumer/">What is direct-to-consumer genetic testing?</a></li><li><a data-pid="20255" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtctesttypes/">What kinds of direct-to-consumer genetic tests are available?</a></li><li>What is genetic ancestry testing?</li><li><a data-pid="20259" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcrisksbenefits/">What are the benefits and risks of direct-to-consumer genetic testing?</a></li><li><a data-pid="20261" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcchoosing/">How do I choose a direct-to-consumer genetic testing company?</a></li><li><a data-pid="20263" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcprocess/">How is direct-to-consumer genetic testing done?</a></li><li><a data-pid="20265" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtccost/">How much does direct-to-consumer genetic testing cost, and is it covered by health insurance?</a></li><li><a data-pid="20267" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcresults/">What do the results of direct-to-consumer genetic testing mean?</a></li><li><a data-pid="20269" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcrawdata/">What can raw data from a direct-to-consumer genetic test tell me?</a></li><li><a data-pid="20271" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtccancer/">Can a direct-to-consumer genetic test tell me whether I will develop cancer?</a></li><li><a data-pid="20273" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcalzheimer/">Can a direct-to-consumer genetic test tell me whether I will develop Alzheimer's disease?</a></li><li><a data-pid="20275" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/neanderthaldna/">What does it mean to have Neanderthal or Denisovan DNA?</a></li><li><a data-pid="20277" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcprivacy/">How do direct-to-consumer genetic testing companies protect their customers’ privacy?</a></li><li><a data-pid="20279" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcinsurancerisk/">Can the results of direct-to-consumer genetic testing affect my ability to get insurance?</a></li><li><a data-pid="20281" href="https://medlineplus.gov/genetics/understanding/dtcgenetictesting/dtcghrpages/">Where can I read more about the diseases and traits covered in my direct-to-consumer genetic testing report?</a></li></ul><p><a data-pid="20081" href="https://medlineplus.gov/genetics/understanding/">Other chapters in Help Me Understand Genetics</a></p></div>
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