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</div><div><span>Creatine phosphokinase test</span></div></div>
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</a><h1 class="with-also" itemprop="name">Creatine phosphokinase test</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Creatine phosphokinase (CPK) is an <a test="test" href="./002353.htm">enzyme</a> in the body. It is found mainly in the heart, brain, and skeletal muscle. This article discusses the test to measure the amount of CPK in the blood.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>A blood sample is needed. This may be taken from a vein. The procedure is called a <a test="test" href="./003423.htm">venipuncture</a>. </p><p>This test may be repeated over 2 or 3 days if you are a patient in the hospital.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>No special preparation is needed most of the time.</p><p>Tell your health care provider about any medicines you are taking.</p><p>Drugs that can increase CPK measurements include the following:</p><ul><li>Alcohol</li><li>Amphotericin B</li><li>Certain anesthetics</li><li>Cocaine</li><li>Fibrate drugs</li><li>Statins</li><li>Steroids, such as dexamethasone</li></ul><p>This list is not all-inclusive.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>You may feel slight pain when the needle is inserted to draw blood. Some people feel only a prick or stinging sensation. Afterward, there may be some throbbing.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>When the total CPK level is very high, it most often means there has been injury or stress to muscle tissue, the heart, or the brain. </p><p>Muscle tissue injury is most likely. When a muscle is damaged, CPK leaks into the bloodstream. Finding which specific form of CPK is high helps determine which tissue has been damaged.</p><p>This test may be used to:</p><ul><li>Diagnose <a test="test" href="./000195.htm">heart attack</a></li><li>Evaluate cause of <a test="test" href="./003079.htm">chest pain</a></li><li>Determine if or how badly a muscle is damaged</li><li>Detect <a test="test" href="./000839.htm">dermatomyositis</a>, <a test="test" href="./000428.htm">polymyositis</a>, and other muscle diseases</li><li>Tell the difference between <a test="test" href="./001315.htm">malignant hyperthermia</a> and postoperative infection </li></ul><p>The pattern and timing of a rise or fall in CPK levels can be significant in making a diagnosis. This is particularly true if a heart attack is suspected. </p><p>In most cases other tests are used instead of or with this test to diagnose a heart attack. </p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Total CPK normal values: </p><ul><li>10 to 120 micrograms per liter (mcg/L) </li></ul><p>Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results. </p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>High CPK levels may be seen in people who have:</p><ul><li>Brain injury or stroke</li><li><a test="test" href="./003200.htm">Convulsions</a></li><li>Delirium tremens</li><li>Dermatomyositis or polymyositis</li><li><a test="test" href="./000053.htm">Electric shock</a></li><li>Heart attack</li><li>Inflammation of the heart muscle (myocarditis)</li><li>Lung tissue death (pulmonary infarction)</li><li>Muscular dystrophies</li><li>Myopathy</li><li><a test="test" href="./000473.htm">Rhabdomyolysis</a></li><li>Trauma</li></ul><p>Other conditions that may give positive test results include:</p><ul><li><a test="test" href="./000353.htm">Hypothyroidism</a></li><li>Hyperthyroidism</li><li><a test="test" href="./000166.htm">Pericarditis following a heart attack</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Risks associated with having blood drawn are slight but may include:</p><ul><li>Excessive bleeding</li><li>Fainting or feeling lightheaded</li><li>Hematoma (blood accumulating under the skin)</li><li>Infection (a slight risk any time the skin is broken) </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Considerations</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Other tests should be done to find the exact location of muscle damage.</p><p>Factors that may affect test results include <a test="test" href="./003419.htm">cardiac catheterization</a>, intramuscular injections, trauma to muscles, recent surgery, and heavy exercise.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>CPK test</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Borg K, Ensrud E. Myopathies. In: Frontera WR, Silver JK, Rizzo TD Jr, eds. <em>Essentials of Physical Medicine and Rehabilitation</em>. 4th ed. Philadelphia, PA: Elsevier; 2019:chap 136.</p><p>Hamel J, Statland JM. Muscle disease. In: Wing EJ, Schiffman FJ, eds. <em>Cecil Essentials of Medicine</em>. 10th ed. Philadelphia, PA: Elsevier; 2022:chap 124.</p><p>Mccullough PA. Interface between renal disease and cardiovascular illness. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. <em>Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine</em>. 12th ed. Philadelphia, PA: Elsevier; 2022:chap 101.</p><p>Pincus MR, Carty RP. Clinical enzymology. In: McPherson RA, Pincus MR, eds. <em>Henry's Clinical Diagnosis and Management by Laboratory Methods</em>. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 21.</p></div></div></section>
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