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<h1> Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery </h1>
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Video: Sleep, Circadian Rhythms, and Opioid Use Disorder
|
||
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|
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<a href="/news/stories/suvorexant-eases-withdrawal">
|
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Research Snapshot: Better Sleep Eases Opioid Withdrawal and Cuts Drug Craving
|
||
</a>
|
||
</p>
|
||
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|
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<img loading="lazy" src="/files/styles/callout_carousel/public/oud-sleep-research-spotlight.jpeg?itok=pGfw55sz" width="900" height="507" alt="man lying in bed unable to sleep with his clock in the foreground" class="img-fluid" />
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|
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|
||
What’s Sleep Got to Do With It?
|
||
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|
||
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|
||
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|
||
</div>
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||
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|
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|
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<a href="/news/stories/sleep-disruption-relapse">
|
||
Is Lack of Sleep a Risk Factor for Relapse?
|
||
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|
||
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|
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|
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|
||
<p class='col-12'>
|
||
<h2>Overview</h2>
|
||
|
||
<h3>The Research Need</h3>
|
||
|
||
<p>More than 75 percent of people with opioid use disorder have sleep problems, such as irregular sleep schedules, not sleeping enough, and/or having a sleep disorder (e.g., insomnia, sleep apnea). While inadequate sleep impairs quality of life, it also may contribute directly to addiction, including reward, stress, emotional regulation, decision making, and social engagement.</p>
|
||
|
||
<h3>About the Program</h3>
|
||
|
||
<p>This program supports basic and clinical research to understand how sleep and circadian rhythms are related to opioid addiction, withdrawal, relapse, and response to medication treatment (including existing medications). This research will identify sleep-controlled molecules and pathways that may serve as potential therapeutic targets for preventing and treating opioid use disorder and addiction.</p>
|
||
|
||
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|
||
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|
||
|
||
|
||
|
||
<h2>Open Funding Opportunities </h2>
|
||
There are no Open Funding Opportunities at this time.
|
||
|
||
|
||
|
||
|
||
|
||
|
||
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|
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|
||
<p> </p><h2>Research Examples</h2><p>Research examples supported by this program include:</p><ul><li>Examining how sleep deficiency affects the risk of relapse in individuals treated for opioid use disorder and whether interventions to improve sleep problems lead to better treatment outcomes</li><li>Studying how sleep problems trigger mechanisms in the brain that increase the risk of opioid misuse</li><li>Investigating the mechanisms that connect sleep disturbance to opioid use disorder, including stress, mood, craving, pain, and addiction risk</li><li>Identifying potential opioid use disorder therapeutic targets to improve sleep and to counteract the effects of sleep disturbance on opiate misuse, addiction, and relapse</li><li>Learning which sleep disturbances influence opioid use disorder medication treatment response</li><li>Studying how medications to treat opioid use disorder affect sleep regulation and circadian rhythms</li></ul>
|
||
|
||
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|
||
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|
||
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|
||
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|
||
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||
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|
||
|
||
|
||
|
||
|
||
<div class="paragraph paragraph--type--accordion paragraph--view-mode--default">
|
||
|
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||
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|
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Funded Institutions and Locations
|
||
</button>
|
||
</h2>
|
||
|
||
</div>
|
||
|
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<div id="collapse-1571547201-0"
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aria-labelledby="heading-1571547201-0"
|
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|
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<div class="card-body">
|
||
<ul><li><strong>Emma Pendleton Bradley Hospital </strong>– Rhode Island</li><li><strong>Harvard Pilgrim Health Care, Inc. </strong>–<strong> </strong>Massachusetts</li><li><strong>Henry Ford Health </strong>– Michigan</li><li><strong>Johns Hopkins University</strong> – Maryland</li><li><strong>Medical College of Wisconsin</strong> – Wisconsin</li><li><strong>Penn State Health Hershey Medical Center </strong>– Pennsylvania</li><li><strong>SRI International</strong> – California</li><li><strong>Stanford University</strong> – California</li><li><strong>University of Alabama at Birmingham </strong>– Alabama</li><li><strong>University of Pittsburgh</strong> – Pennsylvania</li><li><strong>Wayne State University</strong> – Michigan</li><li><strong>Yale University</strong> – Connecticut</li></ul>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
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|
||
|
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Funded Projects
|
||
</button>
|
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</h2>
|
||
|
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<div class="card-body">
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<div class="views-element-container form-group"><div class="viewsreference--view-title">
|
||
</div>
|
||
|
||
<div class="js-view-dom-id-66d8784982887d1b60805b6ba9e8e50bed61caf52ccbcd270560e07b608b742d">
|
||
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||
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||
<div class="pattern">
|
||
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||
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||
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||
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||
|
||
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||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2024
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Evaluating the Role of the Orexin System in Circadian Rhythms of Sleep and Stress in Persons on Medication-Assisted Treatments for Opioid Use Disorder
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=121#project-title-48161>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=121#project-title-48161">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Nov 05, 2024
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2024
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Effects of experimental sleep disruption and fragmentation on cerebral Mu-opioid receptor function, Mu-opioid receptor agonist analgesia, and abuse liability
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=121#project-title-48166>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=121#project-title-48166">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Nov 05, 2024
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2024
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
The Collaboration Linking Opioid Use Disorder and Sleep ("CLOUDS") Study
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=121#project-title-48171>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=121#project-title-48171">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Nov 05, 2024
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2023
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
The Impact of Central Sleep Apnea in Patients Receiving Medications for Opioid Use Disorder
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=121#project-title-46046>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=121#project-title-46046">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Nov 28, 2023
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2023
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Investigating Mechanisms Underpinning Outcomes in People on Opioid Agonist Treatment for OUD: Disentangling Sleep and Circadian Rhythm Influences on Craving and Emotion Regulation
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=121#project-title-46036>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=121#project-title-46036">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Nov 28, 2023
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div style="text-align:right;">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-primary" href=/funding/awarded?research_program=121>
|
||
View all
|
||
</a>
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