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549 lines
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2007 SEPTEMBER–OCTOBER; 358
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<div class="actions">September 13, 2007 <span class="status">[posted]</span>
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<br />
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November 09, 2007
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<span class="status">
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[<a href="#note">Editor's note added</a>]
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<h1>New Look for ClinicalTrials.gov</h1>
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<em><a name = "note">[Editor's</a> Note: The new ClinicalTrials.gov user interface was launched on November 8, 2007 at <a href="//ClinicalTrials.gov/">//ClinicalTrials.gov/</a>.]</em>
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<img src="../new_tb_graphics/i.gif" class="initcap" alt=""
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width="35" height="43" />
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<p class="first">
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<span class="initcap">i</span>n September 2007, <a href="//ClinicalTrials.gov">ClinicalTrials.gov</a> will launch a new user interface, which represents the first significant change to the interface since February 2000. The new user interface will run in parallel with the previous version and after appropriate testing, the new user interface will permanently replace the previous version (approximately two to four weeks after launch). This article describes the new features, including highlighted search terms, more display options, and additional capabilities for viewing studies and search results by topic. Improvements were also made to "Advanced Search" and the display by location on the world map.
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</p>
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<p>
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ClinicalTrials.gov is the NLM<span class="registered">®</span>-developed Web-based registry of clinical research studies. It provides patients, clinicians, researchers, and other members of the general public with access to information about interventional and observational studies including clinical trials of drugs, devices and other interventions. As of August 2007, ClinicalTrials.gov contained over 44,000 clinical research studies in all fifty states and in 150 countries.
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</p>
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<p>
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As reported previously, the scope of ClinicalTrials.gov was expanded to accommodate the <a href="http://www.icmje.org">International Committee of Medical Journal Editors</a> (ICMJE) policy requiring trial registration for publication of research results (<a href="/pubs/techbull/ja05/ja05_clinical_trials.html"><em>NLM Tech Bull. 2005 Jul-Aug;(345):e6)</em></a>. Note that the ICMJE issued an updated statement on trial registration [this link was removed because is it was no longer valid] in June 2007 expanding the requirements to "any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes."
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</p>
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<h2>New Features</h2>
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<p>
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<strong>User Interface Overview</strong><br />
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While the new interface enhances site functionality and navigation significantly, the core aspects of ClinicalTrials.gov have been preserved. The homepage (see <a href="#fig1">Figure 1</a>) now provides explicit links for searching the database (Search for Clinical Trials) and for investigators to register studies (Investigator Instructions). A search box with four navigation links at the top right of each page has replaced the menu bar, allowing new searches for studies to be launched at any time. Pages are now organized by context-sensitive tabs — that is, their labels and functions change as a search progresses from (1) submitting search terms to (2) viewing a list of results to (3) reviewing summaries of individual studies (described below). New features provide users with different options to display results lists and study information based on their needs.
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</p>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig1" id="fig1">
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<img src="graphics/clinicaltrials_fig1a.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="413" /><br />
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<strong>Figure 1: New ClinicalTrials.gov homepage.</strong>
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</a>
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</div>
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<br /><br />
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<p>
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<strong>Search Term Highlighting</strong><br />
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Search terms and synonyms are now highlighted and bolded in study records. A basic search conducted on <em>heart attack</em> retrieved 829 studies, open and closed to recruitment (see <a href="#fig2a">Figures 2a</a> and <a href="#fig2b">Figures 2b</a>). Click on the title of a study record on the List Results page to review the details of a study. In the first retrieved record, both <em>heart attack</em> and its related term <em>myocardial infarction</em> are highlighted (see <a href="#fig3">Figure 3</a>). The search terms heart OR attack are highlighted in a different color than the related term myocardial infarction. For additional information on search capabilities of ClinicalTrials.gov, see previous publications <a href="/pubs/techbull/ja02/ja02_ctgov.html"><em>Update: Expanded ClinicalTrials.gov Search Capabilities. NLM Tech Bull. 2002 Jul-Aug; (327):e5.</em></a> and <a href="/pubs/techbull/so00/so00_clinicaltrials_js.html"><em>Searching ClinicalTrials.gov. NLM Tech Bull. 2000 Sep-Oct;(316)e1.</em></a>
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</p>
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<br /><br />
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<div class="figure" style="width: 506px;">
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<a name="fig2a" id="fig2a">
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<img src="graphics/clinicaltrials_fig2a.gif"
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alt="Screen capture of citation context menu."
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title="" width="504" height="191" /><br />
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<strong>Figure 2a: Basic Search page with search of <em>heart attack</em>.</strong>
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</a>
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</div>
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<br /><br />
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<div class="figure" style="width: 506px;">
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<a name="fig2b" id="fig2b">
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<img src="graphics/clinicaltrials_fig2b.gif"
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alt="Screen capture of citation context menu."
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title="" width="504" height="420" /><br />
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<strong>Figure 2b: List Results page for search of <em>heart attack</em>.</strong>
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</a>
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</div>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig3" id="fig3">
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<img src="graphics/clinicaltrials_fig3.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="712" /><br />
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<strong>Figure 3: Study record from search of <em>heart attack</em> illustrating<br /> highlighted search term and related term (<em>Myocardial Infarction</em>).</strong>
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</a>
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</div>
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<br /><br />
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<p>
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<strong>Display Options</strong></p>
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<ul>
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<li><strong>List Results Page</strong><br />
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The default display on the List Results page includes condition(s) and intervention(s) being studied (see <a href="#fig2b">Figure 2b</a>). Click on "Display Options" ("+" icon or link), above the first study listing in the upper right-hand corner, to reveal sixteen data elements that may be displayed (see <a href="#fig4">Figure 4</a>) in addition to the study title, recruiting status, conditions and interventions. As an option is selected, the corresponding information appears underneath each study listing. After selecting the desired options click on "Hide Display Options" ("-" icon or link) in the upper right-hand corner (see <a href="#fig4">Figure 4</a>) to hide the menu while saving selections for the duration of the search session.
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<br /><br />
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The List Results page defaults to displaying all studies, independent of recruiting status (e.g., recruiting, no longer recruiting, completed). To limit the list to display only studies recruiting participants, click on the "Hide studies that are not recruiting patients" link (left side of the page, directly above the first study listing (see <a href="#fig4">Figure 4</a>).
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<br /><br /></li></ul>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig4" id="fig4">
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<img src="graphics/clinicaltrials_fig4.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="511" /><br />
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<strong>Figure 4: New display options on List Results page (circled).</strong>
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</a>
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</div>
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<br /><br />
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<ul>
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<li><strong>Study Record</strong><br />
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The "Tabular View" and "Contacts and Locations" tabs provide two new display options for viewing a study record. The default (labeled "Full Text View") is similar to the study page on the previous version of the ClinicalTrials.gov site (see <a href="#fig3">Figure 3</a>). Click on the "Tabular View" tab to see a tabular list of data elements, except for contact and location information (see <a href="#fig5">Figure 5</a>). Click on the "Contacts and Locations" tab to view detailed contact information and study locations (see <a href="#fig6">Figure 6</a>).
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</li></ul>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig5" id="fig5">
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<img src="graphics/clinicaltrials_fig5.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="814" /><br />
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<strong>Figure 5: Tabular View of a study record.</strong>
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</a>
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</div>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig6" id="fig6">
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<img src="graphics/clinicaltrials_fig6.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="587" /><br />
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<strong>Figure 6: Contacts and Locations page for a study record.</strong>
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</a>
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</div>
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<br /><br />
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<p><strong>Viewing Studies by Topic/Category</strong></p>
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<ul>
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<li><strong>Studies by Topic and Study Topics</strong>
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<br />
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"Studies by Topic" and "Study Topics" expand on the previous version's feature "Listings" and allows users to view all studies by four main categories: Conditions, Drug Interventions (new), Sponsors, and Locations. Access categorical information for all studies registered in ClinicalTrials.gov by several methods: select "Study Topics" above the search box on the homepage, select a study topic from the right hand side bar on the homepage, or select the "Studies by Topic" tab on the Basic Search page. Within each main category, studies are grouped alphabetically or by "subcategories." An example of viewing studies by category is explained in the following section.<br /><br />
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</li>
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<li><strong>Results by Topic</strong>
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<br />
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"Results by Topic" is similar to "Studies by Topic" and "Study Topics," but accessed by tabs on the List Results page after a query has been submitted. For example, a Basic Search for <em>heart attack</em> yielded 829 studies (see <a href="#fig2b">Figure 2b</a>). Select the "Results by Topic" tab at the top of the List Results page (see <a href="#fig7">Figure 7</a>).
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</li>
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</ul>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig7" id="fig7">
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<img src="graphics/clinicaltrials_fig7.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="359" /><br />
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<strong>Figure 7: Results by Topic page for search of <em>heart attack</em>.
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</strong>
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</a>
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</div>
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<br /><br />
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<p>
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Select a main category and method of viewing (alphabetic or by category) such as "Drug Interventions By Category" (see <a href="#fig8">Figure 8</a>).
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</p>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig8" id="fig8">
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<img src="graphics/clinicaltrials_fig8.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="297" /><br />
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<strong>Figure 8: Drug Interventions by Category for search of <em>heart attack</em>.</strong>
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</a>
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</div>
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<br /><br />
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<p>
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Select "Antilipemic Agents," from the list of drug intervention categories to view types and names of drugs classified as "Antilipemic Agents" (see Figure <a href="#fig9">9</a>) that are part of study records within the search of <em>heart attack</em>.
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</p>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig9" id="fig9">
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<img src="graphics/clinicaltrials_fig9.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="311" /><br />
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<strong>Figure 9: Drug Intervention names for category "Antilipemic Agents."</strong>
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</a>
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</div>
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<br /><br />
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<p>
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Select "Ezetimibe" from the drug interventions provided to display a new List Results page (see <a href="#fig10">Figure 10</a>) with a clearly marked search trail at the top of the page: "Found 5 studies with search of: heart attack|"Ezetimibe" (i.e., equivalent to the query: <em>heart attack</em> AND <em>Ezetimibe</em>).
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</p>
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<br /><br />
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<div class="figure" style="width: 504px;">
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<a name="fig10" id="fig10">
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<img src="graphics/clinicaltrials_fig10.gif"
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alt="Screen capture of citation context menu."
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title="" width="502" height="418" /><br />
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<strong>Figure 10: List Results page with studies related to<br /> search of <em>heart attack</em> AND "Ezetimibe."</strong>
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</a>
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</div>
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<br /><br />
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<p><strong>
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Additional Features</strong><br />
|
||
"Advanced Search" (previously "Focused Search") is now accessible by a tab or a link on the Basic Search page (see <a href="#fig2a">Figure 2a</a>). Advanced Search includes new items, while retaining many of the features described previously (<a href="/pubs/techbull/ja02/ja02_ctgov.html">Update: Expanded ClinicalTrials.gov Search Capabilties. NLM Tech Bull. 2002 Jul-Aug; (327):e5</a>). Users can now limit search based on recruitment status (open or closed to enrollment), study type (interventional, observational, expanded access), and date study record was first received by ClinicalTrials.gov. In addition, users can search for a specific study sponsor and search multiple locations at once (e.g., Washington DC OR Virginia OR Maryland). The function of Advanced Search can also be applied to a search result by selecting the "Refine Search" tab (previously "Search Within Results") on the List Results page and the user’s original search term(s) will be retained (see <a href="#fig11">Figure 11</a>). </p>
|
||
|
||
<br /><br />
|
||
|
||
<div class="figure" style="width: 504px;">
|
||
<a name="fig11" id="fig11">
|
||
<img src="graphics/clinicaltrials_fig11.gif"
|
||
alt="Screen capture of citation context menu."
|
||
title="" width="502" height="724" /><br />
|
||
<strong>Figure 11: Refine Search page with original search of <em>"heart attack."</em></strong>
|
||
</a>
|
||
</div>
|
||
|
||
<br /><br />
|
||
|
||
<p>
|
||
Users can navigate to the next or previous study record from the top of the study record without having to return to the List Results page. The map of study locations is enhanced and users can view the number of registered studies in different regions of the world for a specific search (see <a href="#fig12">Figure 12</a>) or for all studies in the ClinicalTrials.gov database.
|
||
</p>
|
||
|
||
<br /><br />
|
||
|
||
|
||
<div class="figure" style="width: 497px;">
|
||
<a name="fig12" id="fig12">
|
||
<img src="graphics/clinicaltrials_fig12.gif"
|
||
alt="Screen capture of citation context menu."
|
||
title="" width="495" height="665" /><br />
|
||
<strong>Figure 12: Map of study locations for original search of <em>heart attack</em>.</strong>
|
||
</a>
|
||
</div>
|
||
|
||
|
||
|
||
<p><strong>
|
||
Contact Information</strong><br />
|
||
Please send your comments or questions to: <a href="mailto:custserv@nlm.nih.gov">custserv@nlm.nih.gov</a>
|
||
</p>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<p class="authors">
|
||
|
||
|
||
By
|
||
|
||
|
||
|
||
Rebecca J. Williams<br />
|
||
Lister Hill National Center for Biomedical Communications <br />
|
||
|
||
|
||
|
||
|
||
and<br />
|
||
|
||
|
||
|
||
Tony Tse<br />
|
||
Lister Hill National Center for Biomedical Communications <br />
|
||
|
||
|
||
|
||
</p>
|
||
|
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|
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<img src="../new_tb_graphics/black_pixel.gif" width="450" height="1" alt="" />
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<!--************************CHANGE CITATION INFORMATION BELOW*****************************-->
|
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<p class="citation">Williams RJ, Tse T. New Look for ClinicalTrials.gov. NLM Tech Bull. 2007 Sep-Oct; (358):e2.</p>
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