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<!--***********************change issue date and title below**********************-->
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<title>Gene Indexing. NLM Technical Bulletin. Sep-Oct 2002</title>
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<meta name="DC.Subject.IssueNum" content="328" />
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<meta name="DC.Subject.Keyword" content="Data Creation and Maintenance System" />
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<meta name="DC.Subject.Keyword" content="Display Formats" />
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<meta name="DC.Subject.Keyword" content="Genetics" />
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<meta name="DC.Subject.Keyword" content="Indexing" />
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<meta name="DC.Subject.Keyword" content="LinkOut for Libraries" />
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<meta name="DC.Subject.Keyword" content="LocusLink" />
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<meta name="DC.Subject.Keyword" content="Medical Subject Headings" />
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<tr><td width="30"> </td><td width="470"><font size="2"><strong>October 28, 2002</strong> [posted]</font><br /></td><td width="30"> </td></tr>
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<tr><td width="30"> </td><td width="470">
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<!--************************indicate title of article below*********************-->
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<tr><td width="30"> </td><td width="470"><font size="5"><strong>Gene Indexing</strong></font><br /></td><td width="30"> </td></tr>
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<tr><td width="30"> </td><td width="470">
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<br />
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<p>
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<img src="/pubs/techbull/new_tb_graphics/t.gif" border=0 align="left" alt="drop cap letter for t"/>
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he Index Section at NLM has been providing gene indexing for MEDLINE<sup><font size="-2">®</font></sup> citations since the summer of 2001.
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In gene indexing, the indexer creates links between MEDLINE citations and specific records in LocusLink.
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<a href="http://www.ncbi.nlm.nih.gov/gene">LocusLink</a>, which was developed by the
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National Center for Biotechnology Information (NCBI), provides a searchable
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interface to curated sequence and descriptive information about genetic loci. It also includes
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information on official nomenclature, aliases, sequence accessions, phenotypes, EC numbers, MIM
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numbers, UniGene clusters, homology, map locations and related web sites. At the present time, there are six
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organisms in LocusLink - human, mouse, rat, fruitfly, zebrafish and HIV-1. Additional organisms will be added in the
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future.
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</p>
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<p>
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Journal articles that focus on the basic biology of a gene or protein from one of the six organisms
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are candidates for gene indexing. Basic biology includes areas such as function, structure and genetics.
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</p>
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<p>
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As indexers perform subject analysis of journal articles for Medical Subject Headings
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(MeSH<sup><font size="-2">®</font></sup> ) indexing, they look for information that is appropriate
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for linking to LocusLink. The indexer searches LocusLink for the gene or protein.
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If found, a link is created between the MEDLINE record and the LocusLink record. When creating the link, the indexer
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also provides a concise statement in the LocusLink record summarizing the new information about the gene or protein that is reported
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in the article. This statement appears in the GeneRIF (References into Function) data shown in
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the Function section of the LocusLink record.
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</p>
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<p>
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Gene indexing is performed within a module of NLM's web-based Data Creation and Maintenance
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System (DCMS), the system used to create and index journal citations for MEDLINE.
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</p>
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<p>
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Indexers create over six hundred links per week, and since the start of the project in the summer
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of 2001 they have created more than 18,000 links.
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</p>
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<p>
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Users retrieving articles in PubMed<sup><font size="-2">®</font></sup> can go to LocusLink to learn
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more about the genes and proteins being referenced (see Figures <a href="#fig1">1</a>,
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<a href="#fig2">2</a>, <a href="#fig3">3</a>, and <a href="#fig4">4</a> below). Links to LocusLink
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on PubMed citations can be viewed using the LinkOut display format from the Links pull-down menu
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(see Figures <a href="#fig1">1</a> and <a href="#fig2">2</a>).
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</p>
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<center>
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<a name="fig1" id="fig1"> </a>
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<img src="/pubs/techbull/so02/graphics/geneindexing1.gif" alt="Example MEDLINE/PubMed Citation"/>
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</center>
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<br />
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<center>
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<a name="fig2" id="fig2"> </a>
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<img src="/pubs/techbull/so02/graphics/geneindexing2.gif" alt="LinkOut Display for MEDLINE/PubMed Citation Showing Link to LocusLink"/>
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</center>
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<br />
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<center>
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<a name="fig3" id="fig3"> </a>
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<img src="/pubs/techbull/so02/graphics/geneindexing3.gif" alt="Brief LocusLink Record"/>
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</center>
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<br />
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<p>
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Click on the View Loci button to view a fuller LocusLink display including the GeneRIF
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information (see Figure <a href="#fig4">4</a>).
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</p>
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<center>
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<a name="fig4" id="fig4"> </a>
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<img src="/pubs/techbull/so02/graphics/geneindexing4.gif" alt="Portion of Fuller LocusLink Record Showing Some GeneRIF Information"/>
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</center>
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<br />
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<br /><br />
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<p>
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<!--************************indicate article author and section below*******************************-->
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<strong>By Janice Ward</strong><br />
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<strong>Index Section</strong
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</p>
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<!--
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<img src="/pubs/techbull/new_tb_graphics/black_pixel.gif" width="450" height="1"/>
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-->
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<!--************************indicate indexing terms below**********************-->
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<!--
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<p><strong>Indexing Terms</strong></p>
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<p>MEDLINE, Gene Indexing</p>
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<p>Gene Indexing, MEDLINE</p>
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<p>Indexing, Gene</p>
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<p>LocusLink, link to MEDLINE</p>
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<p>MEDLINE, link to LocusLink</p>
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<p>PubMed, link to LocusLink</p>
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<p>PubMed, gene/protein information</p>
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-->
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<!--************************end indexing terms*********************************-->
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<img src="/pubs/techbull/new_tb_graphics/black_pixel.gif" width="450" height="1" alt="black line separting article from citation"/>
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<p>
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<!--************************change citation information below*****************************-->
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<em>Ward J. Gene Indexing. NLM Tech Bull. 2002 Sep-Oct;(328):e6.</em>
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<!--************************end citation information**************************************-->
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<font size="2" face="helvetica, arial"><a href="/nlmhome.html">U.S. National Library of Medicine</a>, 8600 Rockville Pike, Bethesda, MD 20894<br /><a href="http://www.nih.gov/">National Institutes of Health</a>, <a href="//www.hhs.gov/">Department of Health & Human Services</a><br /><a href="/copyright.html">Copyright</a>, <a href="/privacy.html">Privacy</a>, <a href="/accessibility.html">Accessibility</a>, <a href="http://www.nih.gov/icd/od/foia/index.htm">Freedom of Information Act (FOIA)</a><br/><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html">HHS Vulnerability Disclosure</a>
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