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<h1>About TrialGPT</h1>
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<p>Patient recruitment is challenging for clinical trials.
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We introduce TrialGPT, an end-to-end framework for zero-shot patient-to-trial matching with large language models.
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TrialGPT comprises three modules: it first performs large-scale filtering to retrieve candidate trials
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(TrialGPT-Retrieval); then predicts criterion-level patient eligibility (TrialGPT-Matching);
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and finally generates trial-level scores (TrialGPT-Ranking).
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We evaluate TrialGPT on three cohorts of 183 synthetic patients with over 75,000 trial annotations.
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TrialGPT-Retrieval can recall over 90% of relevant trials using less than 6% of the initial collection.
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Manual evaluations on 1,015 patient-criterion pairs show that TrialGPT-Matching achieves an accuracy of 87.3%
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with faithful explanations, close to the expert performance.
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The TrialGPT-Ranking scores are highly correlated with human judgments and outperform the best-competing models
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by 43.8% in ranking and excluding trials. Furthermore, our user study reveals that
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TrialGPT can reduce the screening time by 42.6% in patient recruitment.
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Overall, these results have demonstrated promising opportunities for patient-to-trial matching with TrialGPT.
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<img src="/research/trialgpt/static/main/img/framework.png" alt="TrialGPT Framework">
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<p>Proposed Overall Framework for Effective Patient-to-Trial Matching using Generative AI.</p>
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<h2>Our Team</h2>
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<table>
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<td colspan="2"><strong>Members from NLM</strong></td>
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<tr>
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<td><strong>PI:</strong></td>
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<td>Zhiyong Lu, PhD</td>
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</tr>
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<tr>
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<td><strong>Tech Lead:</strong></td>
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<td>Qiao Jin, MD</td>
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</tr>
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<tr>
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<td><strong>Team Members:</strong></td>
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<td>Yifan Yang; Joey Chan; Nick Wan; Shubo Tian, PhD</td>
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</tr>
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<tr class="highlight-row">
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<td colspan="2"><strong>Collaborators from other NIH Institutes</strong></td>
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<td><strong>NCI:</strong></td>
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<td>Charalampos S Floudas, MD DMSc MS; Dara Bracken-Clarke, MD; Elisabetta Xue, MD; James L. Gulley, MD PhD</td>
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<td><strong>NEI:</strong></td>
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<td>Emily Chew, MD</td>
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<td><strong>NICHD:</strong></td>
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<td>Christina Tatsi, MD MHSc PhD</td>
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<td><strong>UIUC:</strong></td>
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<td>Zifeng Wang; Jimeng Sun, PhD</td>
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<td><strong>Harvard:</strong></td>
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<td>Fangyuan Chen, MD</td>
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</tr>
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<tr>
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<td><strong>Jacobi Medical Center:</strong></td>
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<td>Changlin Gong, MD</td>
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</tr>
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</table>
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