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<meta name="keywords" content="C5394246, disease or syndrome, hh25, hypogonadotropic hypogonadism 25 with anosmia, ndnf, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Hypogonadotropic hypogonadism-25 with anosmia (HH25) is characterized by delayed or absent puberty with low gonadotropic hormones in the setting of low testosterone or estradiol. Affected individuals also exhibit hyposmia or anosmia, with hypoplastic olfactory bulbs on MRI. Intrafamilial variable expressivity and incomplete penetrance has been observed (Messina et al., 2020). For a discussion of genetic heterogeneity of hypogonadotropic hypogonadism with or without anosmia, see 147950." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=1717461
|
||
ConceptID=C5394246
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hypogonadotropic hypogonadism 25 with anosmia<span class="h1sub">(HH25)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1717461</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C5394246</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>HH25; HYPOGONADOTROPIC HYPOGONADISM 25 WITH ANOSMIA</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="NDNF - ID: 79625 - NCBI Gene" href="/gene/79625" class="medgenPMinfo">NDNF</a> (4q27)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0030010" target="_blank">MONDO:0030010</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/618841" target="_blank">618841</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Hypogonadotropic hypogonadism-25 with anosmia (HH25) is characterized by delayed or absent puberty with low gonadotropic hormones in the setting of low testosterone or estradiol. Affected individuals also exhibit hyposmia or anosmia, with hypoplastic olfactory bulbs on MRI. Intrafamilial variable expressivity and incomplete penetrance has been observed (Messina et al., 2020). For a discussion of genetic heterogeneity of hypogonadotropic hypogonadism with or without anosmia, see 147950. [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
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||
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<div class="portlet mgSection" id="ID_102">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_8192"><div><strong>Cryptorchidism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8192</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0010417</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cryptorchidism, or failure of testicular descent, is a common human congenital abnormality with a multifactorial etiology that likely reflects the involvement of endocrine, environmental, and hereditary factors. Cryptorchidism can result in infertility and increases risk for testicular tumors. Testicular descent from abdomen to scrotum occurs in 2 distinct phases: the transabdominal phase and the inguinoscrotal phase (summary by Gorlov et al., 2002).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/8192">Feature record</a> | <a href="/medgen?term=%22Cryptorchidism%22%5BClinical%20Features%5D%20OR%208192%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_115918"><div><strong>Primary amenorrhea</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>115918</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0232939</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormally late or absent menarche in a female with normal secondary sexual characteristics.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/115918">Feature record</a> | <a href="/medgen?term=%22Primary%20amenorrhea%22%5BClinical%20Features%5D%20OR%20115918%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_672766"><div><strong>Hypoplasia of the ovary</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>672766</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0685840</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Developmental hypoplasia of the ovary.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/672766">Feature record</a> | <a href="/medgen?term=%22Hypoplasia%20of%20the%20ovary%22%5BClinical%20Features%5D%20OR%20672766%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1633603"><div><strong>Micropenis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1633603</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1633603">Feature record</a> | <a href="/medgen?term=%22Micropenis%22%5BClinical%20Features%5D%20OR%201633603%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1950"><div><strong>Anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1950</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0003126</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1950">Feature record</a> | <a href="/medgen?term=%22Anosmia%22%5BClinical%20Features%5D%20OR%201950%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_69129"><div><strong>Decreased serum estradiol</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>69129</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0241011</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A reduction below normal concentration of estradiol in the circulation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/69129">Feature record</a> | <a href="/medgen?term=%22Decreased%20serum%20estradiol%22%5BClinical%20Features%5D%20OR%2069129%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_871170"><div><strong>Hypothalamic gonadotropin-releasing hormone deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>871170</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4025644</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/871170">Feature record</a> | <a href="/medgen?term=%22Hypothalamic%20gonadotropin-releasing%20hormone%20deficiency%22%5BClinical%20Features%5D%20OR%20871170%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_892974"><div><strong>Decreased serum testosterone concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>892974</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4073137</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/892974">Feature record</a> | <a href="/medgen?term=%22Decreased%20serum%20testosterone%20concentration%22%5BClinical%20Features%5D%20OR%20892974%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_69129" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased serum estradiol</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_892974" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased serum testosterone concentration</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_871170" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypothalamic gonadotropin-releasing hormone deficiency</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_8192" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cryptorchidism</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_672766" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypoplasia of the ovary</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1633603" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Micropenis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_115918" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary amenorrhea</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1950" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anosmia</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26194704">Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boehm U,
|
||
Bouloux PM,
|
||
Dattani MT,
|
||
de Roux N,
|
||
Dodé C,
|
||
Dunkel L,
|
||
Dwyer AA,
|
||
Giacobini P,
|
||
Hardelin JP,
|
||
Juul A,
|
||
Maghnie M,
|
||
Pitteloud N,
|
||
Prevot V,
|
||
Raivio T,
|
||
Tena-Sempere M,
|
||
Quinton R,
|
||
Young J</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Endocrinol</span>
|
||
2015 Sep;11(9):547-64.
|
||
Epub 2015 Jul 21
|
||
doi: 10.1038/nrendo.2015.112.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26194704" target="_blank">26194704</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%2025%20with%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28963812">Spectral signatures of mirror movements in the sensori-motor connectivity in kallmann syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manara R,
|
||
Di Nardo F,
|
||
Salvalaggio A,
|
||
Sinisi AA,
|
||
Bonanni G,
|
||
Palumbo V,
|
||
Cantone E,
|
||
Brunetti A,
|
||
Di Salle F,
|
||
D'errico A,
|
||
Elefante A,
|
||
Esposito F</span><br />
|
||
<span class="medgenPMjournal">Hum Brain Mapp</span>
|
||
2018 Jan;39(1):42-53.
|
||
Epub 2017 Sep 30
|
||
doi: 10.1002/hbm.23806.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28963812" target="_blank">28963812</a><a href="/pmc/articles/PMC6866347" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26201943">Bone involvement in males with Kallmann disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Iolascon G,
|
||
Frizzi L,
|
||
Bianco M,
|
||
Gimigliano F,
|
||
Palumbo V,
|
||
Sinisi AM,
|
||
Sinisi AA</span><br />
|
||
<span class="medgenPMjournal">Aging Clin Exp Res</span>
|
||
2015 Oct;27 Suppl 1:S31-6.
|
||
Epub 2015 Jul 23
|
||
doi: 10.1007/s40520-015-0421-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26201943" target="_blank">26201943</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23512393">An objective olfactory evaluation and its correlation with magnetic resonance imaging findings in Asian Indian patients with idiopathic hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jagtap VS,
|
||
Sarathi V,
|
||
Lila AR,
|
||
Nair S,
|
||
Bukan A,
|
||
Sankhe SS,
|
||
Shivane V,
|
||
Bandgar T,
|
||
Menon P,
|
||
Shah NS</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2013 Jul-Aug;19(4):669-74.
|
||
doi: 10.4158/EP13008.OR.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23512393" target="_blank">23512393</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17761590">Reversal of idiopathic hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raivio T,
|
||
Falardeau J,
|
||
Dwyer A,
|
||
Quinton R,
|
||
Hayes FJ,
|
||
Hughes VA,
|
||
Cole LW,
|
||
Pearce SH,
|
||
Lee H,
|
||
Boepple P,
|
||
Crowley WF Jr,
|
||
Pitteloud N</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2007 Aug 30;357(9):863-73.
|
||
doi: 10.1056/NEJMoa066494.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17761590" target="_blank">17761590</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12213860">Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pitteloud N,
|
||
Hayes FJ,
|
||
Dwyer A,
|
||
Boepple PA,
|
||
Lee H,
|
||
Crowley WF Jr</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2002 Sep;87(9):4128-36.
|
||
doi: 10.1210/jc.2002-020518.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12213860" target="_blank">12213860</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2025%20with%20anosmia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39596130">Kallmann Syndrome: Functional Analysis of a CHD7 Missense Variant Shows Aberrant RNA Splicing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carriço JN,
|
||
Gonçalves CI,
|
||
Aragüés JM,
|
||
Lemos MC</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2024 Nov 10;25(22)
|
||
doi: 10.3390/ijms252212061.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39596130" target="_blank">39596130</a><a href="/pmc/articles/PMC11594180" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36371229">GNRHR-related central hypogonadism with spontaneous recovery - case report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Šmigoc Schweiger D,
|
||
Davidović Povše M,
|
||
Trebušak Podkrajšek K,
|
||
Battelino T,
|
||
Avbelj Stefanija M</span><br />
|
||
<span class="medgenPMjournal">Ital J Pediatr</span>
|
||
2022 Nov 12;48(1):184.
|
||
doi: 10.1186/s13052-022-01377-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36371229" target="_blank">36371229</a><a href="/pmc/articles/PMC9652797" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26201943">Bone involvement in males with Kallmann disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Iolascon G,
|
||
Frizzi L,
|
||
Bianco M,
|
||
Gimigliano F,
|
||
Palumbo V,
|
||
Sinisi AM,
|
||
Sinisi AA</span><br />
|
||
<span class="medgenPMjournal">Aging Clin Exp Res</span>
|
||
2015 Oct;27 Suppl 1:S31-6.
|
||
Epub 2015 Jul 23
|
||
doi: 10.1007/s40520-015-0421-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26201943" target="_blank">26201943</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26194704">Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boehm U,
|
||
Bouloux PM,
|
||
Dattani MT,
|
||
de Roux N,
|
||
Dodé C,
|
||
Dunkel L,
|
||
Dwyer AA,
|
||
Giacobini P,
|
||
Hardelin JP,
|
||
Juul A,
|
||
Maghnie M,
|
||
Pitteloud N,
|
||
Prevot V,
|
||
Raivio T,
|
||
Tena-Sempere M,
|
||
Quinton R,
|
||
Young J</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Endocrinol</span>
|
||
2015 Sep;11(9):547-64.
|
||
Epub 2015 Jul 21
|
||
doi: 10.1038/nrendo.2015.112.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26194704" target="_blank">26194704</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3101500">Estimating frequency of Kallmann syndrome among hypogonadic and among anosmic patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pawlowitzki IH,
|
||
Diekstall P,
|
||
Schadel A,
|
||
Miny P</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet</span>
|
||
1987 Feb;26(2):473-9.
|
||
doi: 10.1002/ajmg.1320260226.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3101500" target="_blank">3101500</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2025%20with%20anosmia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36371229">GNRHR-related central hypogonadism with spontaneous recovery - case report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Šmigoc Schweiger D,
|
||
Davidović Povše M,
|
||
Trebušak Podkrajšek K,
|
||
Battelino T,
|
||
Avbelj Stefanija M</span><br />
|
||
<span class="medgenPMjournal">Ital J Pediatr</span>
|
||
2022 Nov 12;48(1):184.
|
||
doi: 10.1186/s13052-022-01377-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36371229" target="_blank">36371229</a><a href="/pmc/articles/PMC9652797" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26201943">Bone involvement in males with Kallmann disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Iolascon G,
|
||
Frizzi L,
|
||
Bianco M,
|
||
Gimigliano F,
|
||
Palumbo V,
|
||
Sinisi AM,
|
||
Sinisi AA</span><br />
|
||
<span class="medgenPMjournal">Aging Clin Exp Res</span>
|
||
2015 Oct;27 Suppl 1:S31-6.
|
||
Epub 2015 Jul 23
|
||
doi: 10.1007/s40520-015-0421-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26201943" target="_blank">26201943</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17761590">Reversal of idiopathic hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raivio T,
|
||
Falardeau J,
|
||
Dwyer A,
|
||
Quinton R,
|
||
Hayes FJ,
|
||
Hughes VA,
|
||
Cole LW,
|
||
Pearce SH,
|
||
Lee H,
|
||
Boepple P,
|
||
Crowley WF Jr,
|
||
Pitteloud N</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2007 Aug 30;357(9):863-73.
|
||
doi: 10.1056/NEJMoa066494.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17761590" target="_blank">17761590</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12213860">Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pitteloud N,
|
||
Hayes FJ,
|
||
Dwyer A,
|
||
Boepple PA,
|
||
Lee H,
|
||
Crowley WF Jr</span><br />
|
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<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
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2002 Sep;87(9):4128-36.
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doi: 10.1210/jc.2002-020518.
|
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<span class="bold">PMID: </span><a href="/pubmed/12213860" target="_blank">12213860</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3098018">Gonadotropin responses to low dose pulsatile administration of GnRH in a case of anosmia with hypogonadotropic hypogonadism associated with gonadal dysgenesis 47 XXY.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hazard J,
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Rozenberg I,
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Perlemuter L,
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Kestenbaum S,
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Vendrely E,
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Raoul O,
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Fiet J,
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Villete JM</span><br />
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<span class="medgenPMjournal">Acta Endocrinol (Copenh)</span>
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1986 Dec;113(4):593-7.
|
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doi: 10.1530/acta.0.1130593.
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<span class="bold">PMID: </span><a href="/pubmed/3098018" target="_blank">3098018</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2025%20with%20anosmia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28963812">Spectral signatures of mirror movements in the sensori-motor connectivity in kallmann syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manara R,
|
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Di Nardo F,
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Salvalaggio A,
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Sinisi AA,
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Bonanni G,
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Palumbo V,
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Cantone E,
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Brunetti A,
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Di Salle F,
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D'errico A,
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Elefante A,
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Esposito F</span><br />
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<span class="medgenPMjournal">Hum Brain Mapp</span>
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2018 Jan;39(1):42-53.
|
||
Epub 2017 Sep 30
|
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doi: 10.1002/hbm.23806.
|
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<span class="bold">PMID: </span><a href="/pubmed/28963812" target="_blank">28963812</a><a href="/pmc/articles/PMC6866347" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29255181">Next-generation sequencing of patients with congenital anosmia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alkelai A,
|
||
Olender T,
|
||
Dode C,
|
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Shushan S,
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Tatarskyy P,
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Furman-Haran E,
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Boyko V,
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Gross-Isseroff R,
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Halvorsen M,
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Greenbaum L,
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Milgrom R,
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Yamada K,
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Haneishi A,
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Blau I,
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Lancet D</span><br />
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<span class="medgenPMjournal">Eur J Hum Genet</span>
|
||
2017 Dec;25(12):1377-1387.
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Epub 2017 Nov 13
|
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doi: 10.1038/s41431-017-0014-1.
|
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<span class="bold">PMID: </span><a href="/pubmed/29255181" target="_blank">29255181</a><a href="/pmc/articles/PMC5865213" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26194704">Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boehm U,
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Bouloux PM,
|
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Dattani MT,
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de Roux N,
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Dodé C,
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Dunkel L,
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Dwyer AA,
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Giacobini P,
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Hardelin JP,
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Juul A,
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Maghnie M,
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Pitteloud N,
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Prevot V,
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Raivio T,
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Tena-Sempere M,
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Quinton R,
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Young J</span><br />
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<span class="medgenPMjournal">Nat Rev Endocrinol</span>
|
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2015 Sep;11(9):547-64.
|
||
Epub 2015 Jul 21
|
||
doi: 10.1038/nrendo.2015.112.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26194704" target="_blank">26194704</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17761590">Reversal of idiopathic hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raivio T,
|
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Falardeau J,
|
||
Dwyer A,
|
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Quinton R,
|
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Hayes FJ,
|
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Hughes VA,
|
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Cole LW,
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Pearce SH,
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||
Lee H,
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Boepple P,
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Crowley WF Jr,
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Pitteloud N</span><br />
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<span class="medgenPMjournal">N Engl J Med</span>
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2007 Aug 30;357(9):863-73.
|
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doi: 10.1056/NEJMoa066494.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17761590" target="_blank">17761590</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12213860">Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pitteloud N,
|
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Hayes FJ,
|
||
Dwyer A,
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||
Boepple PA,
|
||
Lee H,
|
||
Crowley WF Jr</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2002 Sep;87(9):4128-36.
|
||
doi: 10.1210/jc.2002-020518.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12213860" target="_blank">12213860</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2025%20with%20anosmia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28963812">Spectral signatures of mirror movements in the sensori-motor connectivity in kallmann syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manara R,
|
||
Di Nardo F,
|
||
Salvalaggio A,
|
||
Sinisi AA,
|
||
Bonanni G,
|
||
Palumbo V,
|
||
Cantone E,
|
||
Brunetti A,
|
||
Di Salle F,
|
||
D'errico A,
|
||
Elefante A,
|
||
Esposito F</span><br />
|
||
<span class="medgenPMjournal">Hum Brain Mapp</span>
|
||
2018 Jan;39(1):42-53.
|
||
Epub 2017 Sep 30
|
||
doi: 10.1002/hbm.23806.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28963812" target="_blank">28963812</a><a href="/pmc/articles/PMC6866347" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29255181">Next-generation sequencing of patients with congenital anosmia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alkelai A,
|
||
Olender T,
|
||
Dode C,
|
||
Shushan S,
|
||
Tatarskyy P,
|
||
Furman-Haran E,
|
||
Boyko V,
|
||
Gross-Isseroff R,
|
||
Halvorsen M,
|
||
Greenbaum L,
|
||
Milgrom R,
|
||
Yamada K,
|
||
Haneishi A,
|
||
Blau I,
|
||
Lancet D</span><br />
|
||
<span class="medgenPMjournal">Eur J Hum Genet</span>
|
||
2017 Dec;25(12):1377-1387.
|
||
Epub 2017 Nov 13
|
||
doi: 10.1038/s41431-017-0014-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29255181" target="_blank">29255181</a><a href="/pmc/articles/PMC5865213" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26201943">Bone involvement in males with Kallmann disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Iolascon G,
|
||
Frizzi L,
|
||
Bianco M,
|
||
Gimigliano F,
|
||
Palumbo V,
|
||
Sinisi AM,
|
||
Sinisi AA</span><br />
|
||
<span class="medgenPMjournal">Aging Clin Exp Res</span>
|
||
2015 Oct;27 Suppl 1:S31-6.
|
||
Epub 2015 Jul 23
|
||
doi: 10.1007/s40520-015-0421-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26201943" target="_blank">26201943</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26194704">Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boehm U,
|
||
Bouloux PM,
|
||
Dattani MT,
|
||
de Roux N,
|
||
Dodé C,
|
||
Dunkel L,
|
||
Dwyer AA,
|
||
Giacobini P,
|
||
Hardelin JP,
|
||
Juul A,
|
||
Maghnie M,
|
||
Pitteloud N,
|
||
Prevot V,
|
||
Raivio T,
|
||
Tena-Sempere M,
|
||
Quinton R,
|
||
Young J</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Endocrinol</span>
|
||
2015 Sep;11(9):547-64.
|
||
Epub 2015 Jul 21
|
||
doi: 10.1038/nrendo.2015.112.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26194704" target="_blank">26194704</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23512393">An objective olfactory evaluation and its correlation with magnetic resonance imaging findings in Asian Indian patients with idiopathic hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jagtap VS,
|
||
Sarathi V,
|
||
Lila AR,
|
||
Nair S,
|
||
Bukan A,
|
||
Sankhe SS,
|
||
Shivane V,
|
||
Bandgar T,
|
||
Menon P,
|
||
Shah NS</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2013 Jul-Aug;19(4):669-74.
|
||
doi: 10.4158/EP13008.OR.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23512393" target="_blank">23512393</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2025%20with%20anosmia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
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||
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|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=618841" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Hypogonadotropic%20hypogonadism%2025%20with%20anosmia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%2025%20with%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet mgSection" id="ID_115">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=616506" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=79625[geneid]" target="_blank">View NDNF variations in ClinVar</a></li><li><a href="https://catalog.coriell.org/Search?q=618841" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/hypogonadotropic_hypogonadism_25_with_anosmia" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Hypogonadotropic%20hypogonadism%2025%20with%20anosmia" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/16387/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
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<li>
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<a href="/pubmed/clinical?term=Hypogonadotropic%20hypogonadism%2025%20with%20anosmia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<li>
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<a href="/pubmed?term=Hypogonadotropic%20hypogonadism%2025%20with%20anosmia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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</li>
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<h3>Related information</h3>
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