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<meta name="keywords" content="C4310678, disease or syndrome, gnb5, ladci, language delay and adhd/cognitive impairment with or without cardiac arrhythmia, language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia, language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia; ladci, ldmls2, lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="GNB5-related neurodevelopmental disorder (GNB5-NDD) is characterized by a spectrum of neurodevelopmental phenotypes that range from severe-to-profound intellectual disability (ID; 31/41 reported individuals), to mild-to-moderate ID (5/41), to normal intellect with severe language disorder (5/41, one extended family). A unique and specific feature of GNB5-NDD – regardless of neurodevelopmental phenotype – is nearly universal bradycardia caused by sinoatrial node dysfunction (sick sinus syndrome). Most individuals with severe and profound ID have a developmental and epileptic encephalopathy with focal seizures or epileptic spasms, as well as visual impairment (central or retinal) with nystagmus, difficulty feeding, and gastroesophageal reflux disease. The risk of early mortality is increased." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia (Concept Id: C4310678)
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<!--
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UID=934645
|
||
ConceptID=C4310678
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia<span class="h1sub">(LDMLS2)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934645</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4310678</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>LDMLS2; LODDER-MERLA SYNDROME, TYPE 2, WITH DEVELOPMENTAL DELAY AND WITH OR WITHOUT CARDIAC ARRHYTHMIA</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="GNB5 - ID: 10681 - NCBI Gene" href="/gene/10681" class="medgenPMinfo">GNB5</a> (15q21.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0014957" target="_blank">MONDO:0014957</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/617182" target="_blank">617182</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
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<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK573218" target="_blank">GNB5-Related Neurodevelopmental Disorder</a></div><div>GNB5-related neurodevelopmental disorder (GNB5-NDD) is characterized by a spectrum of neurodevelopmental phenotypes that range from severe-to-profound intellectual disability (ID; 31/41 reported individuals), to mild-to-moderate ID (5/41), to normal intellect with severe language disorder (5/41, one extended family). A unique and specific feature of GNB5-NDD – regardless of neurodevelopmental phenotype – is nearly universal bradycardia caused by sinoatrial node dysfunction (sick sinus syndrome). Most individuals with severe and profound ID have a developmental and epileptic encephalopathy with focal seizures or epileptic spasms, as well as visual impairment (central or retinal) with nystagmus, difficulty feeding, and gastroesophageal reflux disease. The risk of early mortality is increased. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Summary" target="NBK573218">Summary</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.GeneReview_Scope" target="NBK573218">GeneReview Scope</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Diagnosis" target="NBK573218">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Clinical_Characteristics" target="NBK573218">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Genetically_Related_Allelic_Dis" target="NBK573218">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Differential_Diagnosis" target="NBK573218">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Management" target="NBK573218">Management</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Genetic_Counseling" target="NBK573218">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Resources" target="NBK573218">Resources</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Molecular_Genetics" target="NBK573218">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.Chapter_Notes" target="NBK573218">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK573218#gnb5-ndd.References" target="NBK573218">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Gemma Poke | Lynette Grant Sadleir | Giuseppe Merla<i>, et. al.</i> <a href="/books/NBK573218" target="NBK573218" title="NCBI Bookshelf: GNB5-Related Neurodevelopmental Disorder">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Lodder-Merla syndrome type 2 with developmental delay and with or without cardiac arrhythmia (LDMLS2) is an autosomal recessive neurodevelopmental disorder characterized by severe expressive and receptive language delay apparent from early childhood. Affected individuals have additional developmental or behavioral abnormalities, including attention deficit, hyperactivity, or mild intellectual disability. Some patients develop cardiac arrhythmias reminiscent of sick sinus syndrome (summary by Lodder et al., 2016 and Shamseldin et al., 2016).
|
||
Genotype-Phenotype Correlation
|
||
A direct correlation has been noted between the type of GNB5 variant and the severity of the related phenotype. Individuals with missense variants, both in homozygous or compound heterozygous states (LDMLS2), present with a less severe/moderate phenotype characterized mainly by sinus node dysfunction in combination with mild intellectual disabilities, whereas individuals homozygous for null alleles (LDMLS1) have severe ID, global developmental delay including early infantile developmental and epileptic encephalopathy, hypotonia, as well as sinus node dysfunction (Malerba et al., 2018). <a target="_blank" href="http://www.omim.org/entry/617182">http://www.omim.org/entry/617182</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_8891"><div><strong>Patent foramen ovale</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8891</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0016522</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Failure of the foramen ovale to seal postnatally, leaving a potential conduit between the left and right cardiac atria.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/8891">Feature record</a> | <a href="/medgen?term=%22Patent%20foramen%20ovale%22%5BClinical%20Features%5D%20OR%208891%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_20749"><div><strong>Sick sinus syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>20749</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0037052</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An abnormality involving the generation of the action potential by the sinus node and is characterized by an atrial rate inappropriate for physiological requirements. Manifestations include severe sinus bradycardia, sinus pauses or arrest, sinus node exit block, chronic atrial tachyarrhythmias, alternating periods of atrial bradyarrhythmias and tachyarrhythmias, and inappropriate responses of heart rate during exercise or stress.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/20749">Feature record</a> | <a href="/medgen?term=%22Sick%20sinus%20syndrome%22%5BClinical%20Features%5D%20OR%2020749%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_140901"><div><strong>Bradycardia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>140901</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0428977</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A slower than normal heart rate (in adults, slower than 60 beats per minute).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/140901">Feature record</a> | <a href="/medgen?term=%22Bradycardia%22%5BClinical%20Features%5D%20OR%20140901%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1368658"><div><strong>Gastroesophageal reflux</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1368658</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4317146</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1368658">Feature record</a> | <a href="/medgen?term=%22Gastroesophageal%20reflux%22%5BClinical%20Features%5D%20OR%201368658%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_20693"><div><strong>Seizure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>20693</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0036572</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/20693">Feature record</a> | <a href="/medgen?term=%22Seizure%22%5BClinical%20Features%5D%20OR%2020693%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_98406"><div><strong>Hyperactivity</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98406</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0424295</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hyperactivity is a condition characterized by constant and unusually high levels of activity, even in situations where it is deemed inappropriate.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/98406">Feature record</a> | <a href="/medgen?term=%22Hyperactivity%22%5BClinical%20Features%5D%20OR%2098406%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_105318"><div><strong>Delayed speech and language development</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>105318</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0454644</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A degree of language development that is significantly below the norm for a child of a specified age.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/105318">Feature record</a> | <a href="/medgen?term=%22Delayed%20speech%20and%20language%20development%22%5BClinical%20Features%5D%20OR%20105318%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_107838"><div><strong>Global developmental delay</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>107838</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0557874</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/107838">Feature record</a> | <a href="/medgen?term=%22Global%20developmental%20delay%22%5BClinical%20Features%5D%20OR%20107838%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_220387"><div><strong>Attention deficit hyperactivity disorder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>220387</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1263846</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Attention-deficit/hyperactivity disorder (ADHD) is a behavioral disorder that typically begins in childhood and is characterized by a short attention span (inattention), an inability to be calm and stay still (hyperactivity), and poor impulse control (impulsivity). Some people with ADHD have problems with only inattention or with hyperactivity and impulsivity, but most have problems related to all three features.\n\nIn people with ADHD, the characteristic behaviors are frequent and severe enough to interfere with the activities of daily living such as school, work, and relationships with others. Because of an inability to stay focused on tasks, people with inattention may be easily distracted, forgetful, avoid tasks that require sustained attention, have difficulty organizing tasks, or frequently lose items.\n\nHyperactivity is usually shown by frequent movement. Individuals with this feature often fidget or tap their foot when seated, leave their seat when it is inappropriate to do so (such as in the classroom), or talk a lot and interrupt others.\n\nImpulsivity can result in hasty actions without thought for the consequences. Individuals with poor impulse control may have difficulty waiting for their turn, deferring to others, or considering their actions before acting.\n\nMore than two-thirds of all individuals with ADHD have additional conditions, including insomnia, mood or anxiety disorders, learning disorders, or substance use disorders. Affected individuals may also have autism spectrum disorder, which is characterized by impaired communication and social interaction, or Tourette syndrome, which is a disorder characterized by repetitive and involuntary movements or noises called tics.\n\nIn most affected individuals, ADHD continues throughout life, but in about one-third of individuals, signs and symptoms of ADHD go away by adulthood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/220387">Feature record</a> | <a href="/medgen?term=%22Attention%20deficit%20hyperactivity%20disorder%22%5BClinical%20Features%5D%20OR%20220387%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_381392"><div><strong>Motor delay</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>381392</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854301</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A type of Developmental delay characterized by a delay in acquiring motor skills.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/381392">Feature record</a> | <a href="/medgen?term=%22Motor%20delay%22%5BClinical%20Features%5D%20OR%20381392%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_340737"><div><strong>Absent speech</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>340737</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854882</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Complete lack of development of speech and language abilities.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/340737">Feature record</a> | <a href="/medgen?term=%22Absent%20speech%22%5BClinical%20Features%5D%20OR%20340737%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_356863"><div><strong>Poor fine motor coordination</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>356863</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1867864</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/356863">Feature record</a> | <a href="/medgen?term=%22Poor%20fine%20motor%20coordination%22%5BClinical%20Features%5D%20OR%20356863%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_811461"><div><strong>Intellectual disability</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>811461</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3714756</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Intellectual disability, previously referred to as mental retardation, is characterized by subnormal intellectual functioning that occurs during the developmental period. It is defined by an IQ score below 70.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/811461">Feature record</a> | <a href="/medgen?term=%22Intellectual%20disability%22%5BClinical%20Features%5D%20OR%20811461%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_10133"><div><strong>Hypotonia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>10133</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0026827</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypotonia is an abnormally low muscle tone (the amount of tension or resistance to movement in a muscle). Even when relaxed, muscles have a continuous and passive partial contraction which provides some resistance to passive stretching. Hypotonia thus manifests as diminished resistance to passive stretching. Hypotonia is not the same as muscle weakness, although the two conditions can co-exist.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/10133">Feature record</a> | <a href="/medgen?term=%22Hypotonia%22%5BClinical%20Features%5D%20OR%2010133%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1644158"><div><strong>Microcephaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1644158</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551563</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Head circumference below 2 standard deviations below the mean for age and gender.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1644158">Feature record</a> | <a href="/medgen?term=%22Microcephaly%22%5BClinical%20Features%5D%20OR%201644158%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_45166"><div><strong>Nystagmus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45166</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0028738</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/45166">Feature record</a> | <a href="/medgen?term=%22Nystagmus%22%5BClinical%20Features%5D%20OR%2045166%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_140901" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bradycardia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_8891" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Patent foramen ovale</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_20749" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sick sinus syndrome</a></span></li></ul></li><li><span class="TLline">Abnormality of the digestive system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1368658" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastroesophageal reflux</a></span></li></ul></li><li><span class="TLline">Abnormality of the eye</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_45166" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Nystagmus</a></span></li></ul></li><li><span class="TLline">Abnormality of the musculoskeletal system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_10133" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypotonia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1644158" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Microcephaly</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_340737" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Absent speech</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_220387" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Attention deficit hyperactivity disorder</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_105318" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Delayed speech and language development</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_107838" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Global developmental delay</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_98406" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperactivity</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_811461" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual disability</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_381392" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Motor delay</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_356863" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Poor fine motor coordination</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_20693" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Seizure</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32561223">Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Corrado D,
|
||
Perazzolo Marra M,
|
||
Zorzi A,
|
||
Beffagna G,
|
||
Cipriani A,
|
||
Lazzari M,
|
||
Migliore F,
|
||
Pilichou K,
|
||
Rampazzo A,
|
||
Rigato I,
|
||
Rizzo S,
|
||
Thiene G,
|
||
Anastasakis A,
|
||
Asimaki A,
|
||
Bucciarelli-Ducci C,
|
||
Haugaa KH,
|
||
Marchlinski FE,
|
||
Mazzanti A,
|
||
McKenna WJ,
|
||
Pantazis A,
|
||
Pelliccia A,
|
||
Schmied C,
|
||
Sharma S,
|
||
Wichter T,
|
||
Bauce B,
|
||
Basso C</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiol</span>
|
||
2020 Nov 15;319:106-114.
|
||
Epub 2020 Jun 16
|
||
doi: 10.1016/j.ijcard.2020.06.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32561223" target="_blank">32561223</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32199055">Congenital heart disease, prenatal diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Meller CH,
|
||
Grinenco S,
|
||
Aiello H,
|
||
Córdoba A,
|
||
Sáenz-Tejeira MM,
|
||
Marantz P,
|
||
Otaño L</span><br />
|
||
<span class="medgenPMjournal">Arch Argent Pediatr</span>
|
||
2020 Apr;118(2):e149-e161.
|
||
doi: 10.5546/aap.2020.eng.e149.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32199055" target="_blank">32199055</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25980576">2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sheldon RS,
|
||
Grubb BP 2nd,
|
||
Olshansky B,
|
||
Shen WK,
|
||
Calkins H,
|
||
Brignole M,
|
||
Raj SR,
|
||
Krahn AD,
|
||
Morillo CA,
|
||
Stewart JM,
|
||
Sutton R,
|
||
Sandroni P,
|
||
Friday KJ,
|
||
Hachul DT,
|
||
Cohen MI,
|
||
Lau DH,
|
||
Mayuga KA,
|
||
Moak JP,
|
||
Sandhu RK,
|
||
Kanjwal K</span><br />
|
||
<span class="medgenPMjournal">Heart Rhythm</span>
|
||
2015 Jun;12(6):e41-63.
|
||
Epub 2015 May 14
|
||
doi: 10.1016/j.hrthm.2015.03.029.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25980576" target="_blank">25980576</a><a href="/pmc/articles/PMC5267948" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(language%20delay%20and%20attention%20deficit-hyperactivity%20disorder%2Fcognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (10811)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33654273">Electroimmunology and cardiac arrhythmia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grune J,
|
||
Yamazoe M,
|
||
Nahrendorf M</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Cardiol</span>
|
||
2021 Aug;18(8):547-564.
|
||
Epub 2021 Mar 2
|
||
doi: 10.1038/s41569-021-00520-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33654273" target="_blank">33654273</a><a href="/pmc/articles/PMC9703448" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32771194">Epicardial Ablation Complications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tarantino N,
|
||
Della Rocca DG,
|
||
Faggioni M,
|
||
Zhang XD,
|
||
Mohanty S,
|
||
Anannab A,
|
||
Canpolat U,
|
||
Ayhan H,
|
||
Bassiouny M,
|
||
Sahore A,
|
||
Aytemir K,
|
||
Sarcon A,
|
||
Forleo GB,
|
||
Lavalle C,
|
||
Horton RP,
|
||
Trivedi C,
|
||
Al-Ahmad A,
|
||
Romero J,
|
||
Burkhardt DJ,
|
||
Gallinghouse JG,
|
||
Di Biase L,
|
||
Natale A</span><br />
|
||
<span class="medgenPMjournal">Card Electrophysiol Clin</span>
|
||
2020 Sep;12(3):409-418.
|
||
doi: 10.1016/j.ccep.2020.06.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32771194" target="_blank">32771194</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31378326">When Is Syncope Arrhythmic?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martow E,
|
||
Sandhu R</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2019 Sep;103(5):793-807.
|
||
Epub 2019 Jun 26
|
||
doi: 10.1016/j.mcna.2019.05.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31378326" target="_blank">31378326</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28314851">Electrophysiology of Hypokalemia and Hyperkalemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weiss JN,
|
||
Qu Z,
|
||
Shivkumar K</span><br />
|
||
<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
|
||
2017 Mar;10(3)
|
||
doi: 10.1161/CIRCEP.116.004667.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28314851" target="_blank">28314851</a><a href="/pmc/articles/PMC5399982" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27830772">Diagnosis, pathophysiology, and management of exercise-induced arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guasch E,
|
||
Mont L</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Cardiol</span>
|
||
2017 Feb;14(2):88-101.
|
||
Epub 2016 Nov 10
|
||
doi: 10.1038/nrcardio.2016.173.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27830772" target="_blank">27830772</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder%2Fcognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (87238)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37973359">Management of Arrhythmias in the Cardiovascular Intensive Care Unit.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klinkhammer B,
|
||
Glotzer TV</span><br />
|
||
<span class="medgenPMjournal">Crit Care Clin</span>
|
||
2024 Jan;40(1):89-103.
|
||
Epub 2023 Jul 31
|
||
doi: 10.1016/j.ccc.2023.06.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37973359" target="_blank">37973359</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31378326">When Is Syncope Arrhythmic?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martow E,
|
||
Sandhu R</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2019 Sep;103(5):793-807.
|
||
Epub 2019 Jun 26
|
||
doi: 10.1016/j.mcna.2019.05.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31378326" target="_blank">31378326</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29875055">Arrhythmia-Induced Cardiomyopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sossalla S,
|
||
Vollmann D</span><br />
|
||
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
|
||
2018 May 11;115(19):335-341.
|
||
doi: 10.3238/arztebl.2018.0335.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29875055" target="_blank">29875055</a><a href="/pmc/articles/PMC5997886" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28314851">Electrophysiology of Hypokalemia and Hyperkalemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weiss JN,
|
||
Qu Z,
|
||
Shivkumar K</span><br />
|
||
<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
|
||
2017 Mar;10(3)
|
||
doi: 10.1161/CIRCEP.116.004667.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28314851" target="_blank">28314851</a><a href="/pmc/articles/PMC5399982" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25737133">Cardiac Arrhythmias: Diagnosis, Symptoms, and Treatments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fu DG</span><br />
|
||
<span class="medgenPMjournal">Cell Biochem Biophys</span>
|
||
2015 Nov;73(2):291-296.
|
||
doi: 10.1007/s12013-015-0626-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25737133" target="_blank">25737133</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder%2Fcognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (72169)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32771194">Epicardial Ablation Complications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tarantino N,
|
||
Della Rocca DG,
|
||
Faggioni M,
|
||
Zhang XD,
|
||
Mohanty S,
|
||
Anannab A,
|
||
Canpolat U,
|
||
Ayhan H,
|
||
Bassiouny M,
|
||
Sahore A,
|
||
Aytemir K,
|
||
Sarcon A,
|
||
Forleo GB,
|
||
Lavalle C,
|
||
Horton RP,
|
||
Trivedi C,
|
||
Al-Ahmad A,
|
||
Romero J,
|
||
Burkhardt DJ,
|
||
Gallinghouse JG,
|
||
Di Biase L,
|
||
Natale A</span><br />
|
||
<span class="medgenPMjournal">Card Electrophysiol Clin</span>
|
||
2020 Sep;12(3):409-418.
|
||
doi: 10.1016/j.ccep.2020.06.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32771194" target="_blank">32771194</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29961863">Sex differences in cardiac arrhythmia: a consensus document of the European Heart Rhythm Association, endorsed by the Heart Rhythm Society and Asia Pacific Heart Rhythm Society.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Linde C,
|
||
Bongiorni MG,
|
||
Birgersdotter-Green U,
|
||
Curtis AB,
|
||
Deisenhofer I,
|
||
Furokawa T,
|
||
Gillis AM,
|
||
Haugaa KH,
|
||
Lip GYH,
|
||
Van Gelder I,
|
||
Malik M,
|
||
Poole J,
|
||
Potpara T,
|
||
Savelieva I,
|
||
Sarkozy A;
|
||
ESC Scientific Document Group</span><br />
|
||
<span class="medgenPMjournal">Europace</span>
|
||
2018 Oct 1;20(10):1565-1565ao.
|
||
doi: 10.1093/europace/euy067.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29961863" target="_blank">29961863</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29875055">Arrhythmia-Induced Cardiomyopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sossalla S,
|
||
Vollmann D</span><br />
|
||
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
|
||
2018 May 11;115(19):335-341.
|
||
doi: 10.3238/arztebl.2018.0335.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29875055" target="_blank">29875055</a><a href="/pmc/articles/PMC5997886" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25737133">Cardiac Arrhythmias: Diagnosis, Symptoms, and Treatments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fu DG</span><br />
|
||
<span class="medgenPMjournal">Cell Biochem Biophys</span>
|
||
2015 Nov;73(2):291-296.
|
||
doi: 10.1007/s12013-015-0626-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25737133" target="_blank">25737133</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25336366">Contemporary management of arrhythmias during pregnancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Enriquez AD,
|
||
Economy KE,
|
||
Tedrow UB</span><br />
|
||
<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
|
||
2014 Oct;7(5):961-7.
|
||
doi: 10.1161/CIRCEP.114.001517.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25336366" target="_blank">25336366</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder%2Fcognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (77120)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38568602">Risk of Cardiac Arrhythmias Among Climbers on Mount Everest.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sherpa K,
|
||
Sherpa PP,
|
||
Sherpa T,
|
||
Rothenbühler M,
|
||
Ryffel C,
|
||
Sherpa D,
|
||
Sherpa DR,
|
||
Sherchand O,
|
||
Galuszka O,
|
||
Dernektsi C,
|
||
Reichlin T,
|
||
Pilgrim T</span><br />
|
||
<span class="medgenPMjournal">JAMA Cardiol</span>
|
||
2024 May 1;9(5):480-485.
|
||
doi: 10.1001/jamacardio.2024.0364.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38568602" target="_blank">38568602</a><a href="/pmc/articles/PMC10993151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33302973">Incidence rate and clinical impacts of arrhythmia following COVID-19: a systematic review and meta-analysis of 17,435 patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liao SC,
|
||
Shao SC,
|
||
Cheng CW,
|
||
Chen YC,
|
||
Hung MJ</span><br />
|
||
<span class="medgenPMjournal">Crit Care</span>
|
||
2020 Dec 10;24(1):690.
|
||
doi: 10.1186/s13054-020-03368-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33302973" target="_blank">33302973</a><a href="/pmc/articles/PMC7727094" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31754784">Complications of catheter ablation: incidence, diagnosis and clinical management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sorgente A,
|
||
Cappato R</span><br />
|
||
<span class="medgenPMjournal">Herzschrittmacherther Elektrophysiol</span>
|
||
2019 Dec;30(4):363-370.
|
||
Epub 2019 Nov 21
|
||
doi: 10.1007/s00399-019-00652-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31754784" target="_blank">31754784</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23981310">The J wave patterns and risk of sudden cardiac death in patients with coronary artery disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zeitler EP,
|
||
Sun AY</span><br />
|
||
<span class="medgenPMjournal">J Electrocardiol</span>
|
||
2013 Sep-Oct;46(5):446-50.
|
||
doi: 10.1016/j.jelectrocard.2013.06.026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23981310" target="_blank">23981310</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20522153">Athletes and arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Link MS,
|
||
Estes NA</span><br />
|
||
<span class="medgenPMjournal">J Cardiovasc Electrophysiol</span>
|
||
2010 Oct;21(10):1184-9.
|
||
doi: 10.1111/j.1540-8167.2010.01808.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20522153" target="_blank">20522153</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder%2Fcognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53794)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34448706">Diagnostic Accuracy of Smartwatches for the Detection of Cardiac Arrhythmia: Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nazarian S,
|
||
Lam K,
|
||
Darzi A,
|
||
Ashrafian H</span><br />
|
||
<span class="medgenPMjournal">J Med Internet Res</span>
|
||
2021 Aug 27;23(8):e28974.
|
||
doi: 10.2196/28974.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34448706" target="_blank">34448706</a><a href="/pmc/articles/PMC8433941" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32101812">Cardiac Arrhythmias in Autoimmune Diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gawałko M,
|
||
Balsam P,
|
||
Lodziński P,
|
||
Grabowski M,
|
||
Krzowski B,
|
||
Opolski G,
|
||
Kosiuk J</span><br />
|
||
<span class="medgenPMjournal">Circ J</span>
|
||
2020 Apr 24;84(5):685-694.
|
||
Epub 2020 Feb 26
|
||
doi: 10.1253/circj.CJ-19-0705.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32101812" target="_blank">32101812</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30722682">Device Programming for His Bundle Pacing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Burri H,
|
||
Keene D,
|
||
Whinnett Z,
|
||
Zanon F,
|
||
Vijayaraman P</span><br />
|
||
<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
|
||
2019 Feb;12(2):e006816.
|
||
doi: 10.1161/CIRCEP.118.006816.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30722682" target="_blank">30722682</a><a href="/pmc/articles/PMC6420120" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28543823">Unknown Intracardiac Electrogram.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Prystowsky EN</span><br />
|
||
<span class="medgenPMjournal">J Cardiovasc Electrophysiol</span>
|
||
2017 May;28(5):570.
|
||
doi: 10.1111/jce.13215.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28543823" target="_blank">28543823</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27324363">The Future of Arrhythmias and Electrophysiology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Albert CM,
|
||
Stevenson WG</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2016 Jun 21;133(25):2687-96.
|
||
doi: 10.1161/CIRCULATIONAHA.116.023519.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27324363" target="_blank">27324363</a><a href="/pmc/articles/PMC4930113" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder%2Fcognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (52601)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/35734489">CONGENITAL LONG QT SYNDROME: A SYSTEMATIC REVIEW.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Galić E,
|
||
Bešlić P,
|
||
Kilić P,
|
||
Planinić Z,
|
||
Pašalić A,
|
||
Galić I,
|
||
Ćubela VV,
|
||
Pekić P</span><br />
|
||
<span class="medgenPMjournal">Acta Clin Croat</span>
|
||
2021 Dec;60(4):739-748.
|
||
doi: 10.20471/acc.2021.60.04.22.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35734489" target="_blank">35734489</a><a href="/pmc/articles/PMC9196236" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32114706">Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abdelhamid AS,
|
||
Brown TJ,
|
||
Brainard JS,
|
||
Biswas P,
|
||
Thorpe GC,
|
||
Moore HJ,
|
||
Deane KH,
|
||
Summerbell CD,
|
||
Worthington HV,
|
||
Song F,
|
||
Hooper L</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2020 Feb 29;3(3):CD003177.
|
||
doi: 10.1002/14651858.CD003177.pub5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32114706" target="_blank">32114706</a><a href="/pmc/articles/PMC7049091" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30354657">Modernized Classification of Cardiac Antiarrhythmic Drugs.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lei M,
|
||
Wu L,
|
||
Terrar DA,
|
||
Huang CL</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2018 Oct 23;138(17):1879-1896.
|
||
doi: 10.1161/CIRCULATIONAHA.118.035455.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30354657" target="_blank">30354657</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29438514">Antiarrhythmic drugs-clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology (ESC) Working Group on Cardiovascular Pharmacology, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and International Society of Cardiovascular Pharmacotherapy (ISCP).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dan GA,
|
||
Martinez-Rubio A,
|
||
Agewall S,
|
||
Boriani G,
|
||
Borggrefe M,
|
||
Gaita F,
|
||
van Gelder I,
|
||
Gorenek B,
|
||
Kaski JC,
|
||
Kjeldsen K,
|
||
Lip GYH,
|
||
Merkely B,
|
||
Okumura K,
|
||
Piccini JP,
|
||
Potpara T,
|
||
Poulsen BK,
|
||
Saba M,
|
||
Savelieva I,
|
||
Tamargo JL,
|
||
Wolpert C;
|
||
ESC Scientific Document Group</span><br />
|
||
<span class="medgenPMjournal">Europace</span>
|
||
2018 May 1;20(5):731-732an.
|
||
doi: 10.1093/europace/eux373.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29438514" target="_blank">29438514</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25557883">Society for maternal-fetal medicine (SMFM) clinical guideline #7: nonimmune hydrops fetalis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Society for Maternal-Fetal Medicine (SMFM),
|
||
Norton ME,
|
||
Chauhan SP,
|
||
Dashe JS</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2015 Feb;212(2):127-39.
|
||
Epub 2014 Dec 31
|
||
doi: 10.1016/j.ajog.2014.12.018.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25557883" target="_blank">25557883</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder%2Fcognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2917)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4310678%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (5)</a></li>
|
||
<li><a href="/gtr/tests?term=C4310678%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (5)</a></li>
|
||
<li><a href="/gtr/tests?term=C4310678%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C4310678%5bDISCUI%5d" target="_blank">See all (5)</a></total></li>
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||
</ul></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=617182" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder/cognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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</div>
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|
||
<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(language%20delay%20and%20attention%20deficit-hyperactivity%20disorder%2Fcognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=604447" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=10681[geneid]" target="_blank">View GNB5 variations in ClinVar</a></li><li><a href="https://catalog.coriell.org/Search?q=617182" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/lodder_merla_syndrome_type_2_with_developmental_delay_and_with_or_without_cardiac_arrhythmia" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder/cognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia" target="_blank">MedlinePlus</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
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||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/34436834" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder/cognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Language%20delay%20and%20attention%20deficit-hyperactivity%20disorder/cognitive%20impairment%20with%20or%20without%20cardiac%20arrhythmia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=934645" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=934645" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C4310678[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C4310678[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=934645" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=934645" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
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