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<meta name="keywords" content="C4225426, ftc, hras, minpp1, neoplastic process, nmtc2, nras, srgap1, thyroid cancer, follicular, thyroid cancer, nonmedullary, 2, thyroid cancer, nonmedullary, 2, autosomal dominant, somatic mutation, thyroid cancer, nonmedullary, 2, susceptibility to, thyroid cancer, nonmedullary, type 2, thyroid carcinoma, follicular, thyroid carcinoma, follicular, autosomal dominant, somatic mutation, thyroid carcinoma, follicular, somatic, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100, Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). Follicular thyroid cancer (FTC) accounts for approximately 15% of NMTC and is defined by invasive features that result in infiltration of blood vessels and/or full penetration of the tumor capsule, in the absence of the nuclear alterations that characterize papillary carcinoma. FTC is rarely multifocal and usually does not metastasize to the regional lymph nodes but tends to spread via the bloodstream to the lung and bones. An important histologic variant of FTC is the oncocytic (Hurthle cell, oxyphilic) follicular carcinoma composed of eosinophilic cells replete with mitochondria (summary by Bonora et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=904175
|
||
ConceptID=C4225426
|
||
-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Thyroid cancer, nonmedullary, 2<span class="h1sub">(NMTC2)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>904175</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4225426</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>NMTC2; THYROID CANCER, NONMEDULLARY, 2, SUSCEPTIBILITY TO; THYROID CARCINOMA, FOLLICULAR; Thyroid carcinoma, follicular, somatic</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="HRAS - ID: 3265 - NCBI Gene" href="/gene/3265" class="medgenPMinfo">HRAS</a> (11p15.5); <a target="_blank" title="MINPP1 - ID: 9562 - NCBI Gene" href="/gene/9562" class="medgenPMinfo">MINPP1</a> (10q23.2); <a target="_blank" title="NRAS - ID: 4893 - NCBI Gene" href="/gene/4893" class="medgenPMinfo">NRAS</a> (1p13.2); <a target="_blank" title="SRGAP1 - ID: 57522 - NCBI Gene" href="/gene/57522" class="medgenPMinfo">SRGAP1</a> (12q14.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0008566" target="_blank">MONDO:0008566</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/188470" target="_blank">188470</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100, Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). Follicular thyroid cancer (FTC) accounts for approximately 15% of NMTC and is defined by invasive features that result in infiltration of blood vessels and/or full penetration of the tumor capsule, in the absence of the nuclear alterations that characterize papillary carcinoma. FTC is rarely multifocal and usually does not metastasize to the regional lymph nodes but tends to spread via the bloodstream to the lung and bones. An important histologic variant of FTC is the oncocytic (Hurthle cell, oxyphilic) follicular carcinoma composed of eosinophilic cells replete with mitochondria (summary by Bonora et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_64630"><div><strong>Follicular thyroid carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>64630</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0206682</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of an follicular adenocarcinoma of the thyroid gland.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/64630">Feature record</a> | <a href="/medgen?term=%22Follicular%20thyroid%20carcinoma%22%5BClinical%20Features%5D%20OR%2064630%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_66773"><div><strong>Papillary thyroid carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66773</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0238463</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of a papillary adenocarcinoma of the thyroid gland.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/66773">Feature record</a> | <a href="/medgen?term=%22Papillary%20thyroid%20carcinoma%22%5BClinical%20Features%5D%20OR%2066773%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_502247"><div><strong>Familial nonmedullary thyroid carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>502247</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3501843</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare non-syndromic form of thyroid cancer characterized by occurrence of thyroid carcinoma (TC) as the primary feature in a familial setting.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/502247">Feature record</a> | <a href="/medgen?term=%22Familial%20nonmedullary%20thyroid%20carcinoma%22%5BClinical%20Features%5D%20OR%20502247%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_502247" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial nonmedullary thyroid carcinoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_64630" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Follicular thyroid carcinoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_66773" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Papillary thyroid carcinoma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35948029">Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haddad RI,
|
||
Bischoff L,
|
||
Ball D,
|
||
Bernet V,
|
||
Blomain E,
|
||
Busaidy NL,
|
||
Campbell M,
|
||
Dickson P,
|
||
Duh QY,
|
||
Ehya H,
|
||
Goldner WS,
|
||
Guo T,
|
||
Haymart M,
|
||
Holt S,
|
||
Hunt JP,
|
||
Iagaru A,
|
||
Kandeel F,
|
||
Lamonica DM,
|
||
Mandel S,
|
||
Markovina S,
|
||
McIver B,
|
||
Raeburn CD,
|
||
Rezaee R,
|
||
Ridge JA,
|
||
Roth MY,
|
||
Scheri RP,
|
||
Shah JP,
|
||
Sipos JA,
|
||
Sippel R,
|
||
Sturgeon C,
|
||
Wang TN,
|
||
Wirth LJ,
|
||
Wong RJ,
|
||
Yeh M,
|
||
Cassara CJ,
|
||
Darlow S</span><br />
|
||
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
|
||
2022 Aug;20(8):925-951.
|
||
doi: 10.6004/jnccn.2022.0040.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35948029" target="_blank">35948029</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35243857">Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klubo-Gwiezdzinska J,
|
||
Wartofsky L</span><br />
|
||
<span class="medgenPMjournal">Pol Arch Intern Med</span>
|
||
2022 Mar 30;132(3)
|
||
Epub 2022 Mar 3
|
||
doi: 10.20452/pamw.16222.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35243857" target="_blank">35243857</a><a href="/pmc/articles/PMC9478900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25900731">Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Francis GL,
|
||
Waguespack SG,
|
||
Bauer AJ,
|
||
Angelos P,
|
||
Benvenga S,
|
||
Cerutti JM,
|
||
Dinauer CA,
|
||
Hamilton J,
|
||
Hay ID,
|
||
Luster M,
|
||
Parisi MT,
|
||
Rachmiel M,
|
||
Thompson GB,
|
||
Yamashita S;
|
||
American Thyroid Association Guidelines Task Force</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2015 Jul;25(7):716-59.
|
||
doi: 10.1089/thy.2014.0460.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25900731" target="_blank">25900731</a><a href="/pmc/articles/PMC4854274" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(thyroid%20cancer%2C%20nonmedullary%2C%202)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (402)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng230" target="_blank">UK NICE Guideline NG230, Thyroid cancer: assessment and management</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.cms.gov/Medicare/Coverage/DeterminationProcess/downloads/id90TA.pdf" target="_blank">Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39645560">Feasibility of Lobectomy in Selected Patients with Unilateral N1b Papillary Thyroid Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li D,
|
||
Zhang G,
|
||
Li X,
|
||
Xu S,
|
||
Sun H,
|
||
Liu Y,
|
||
Wu G,
|
||
Zheng H,
|
||
Zhang X,
|
||
Zheng G</span><br />
|
||
<span class="medgenPMjournal">Ann Surg Oncol</span>
|
||
2025 Apr;32(4):2344-2352.
|
||
Epub 2024 Dec 7
|
||
doi: 10.1245/s10434-024-16643-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39645560" target="_blank">39645560</a><a href="/pmc/articles/PMC11882689" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37916932">Risk stratification of papillary thyroid cancers using multidimensional machine learning.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Wu F,
|
||
Ge W,
|
||
Zhang Y,
|
||
Hu Y,
|
||
Zhao L,
|
||
Gou W,
|
||
Shi J,
|
||
Ni Y,
|
||
Li L,
|
||
Fu W,
|
||
Lin X,
|
||
Yu Y,
|
||
Han Z,
|
||
Chen C,
|
||
Xu R,
|
||
Zhang S,
|
||
Zhou L,
|
||
Pan G,
|
||
Peng Y,
|
||
Mao L,
|
||
Zhou T,
|
||
Zheng J,
|
||
Zheng H,
|
||
Sun Y,
|
||
Guo T,
|
||
Luo D</span><br />
|
||
<span class="medgenPMjournal">Int J Surg</span>
|
||
2024 Jan 1;110(1):372-384.
|
||
doi: 10.1097/JS9.0000000000000814.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37916932" target="_blank">37916932</a><a href="/pmc/articles/PMC10793787" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32477264">Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mao J,
|
||
Zhang Q,
|
||
Zhang H,
|
||
Zheng K,
|
||
Wang R,
|
||
Wang G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:265.
|
||
Epub 2020 May 15
|
||
doi: 10.3389/fendo.2020.00265.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32477264" target="_blank">32477264</a><a href="/pmc/articles/PMC7242632" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30844924">Papillary microcarcinoma of the thyroid gland: current controversies and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rovira A,
|
||
Nixon IJ,
|
||
Simo R</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Otolaryngol Head Neck Surg</span>
|
||
2019 Apr;27(2):110-116.
|
||
doi: 10.1097/MOO.0000000000000520.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30844924" target="_blank">30844924</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28942234">Second generation of familial nonmedullary thyroid carcinoma: A meta-analysis on the clinicopathologic features and prognosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou YM,
|
||
Luo H,
|
||
Gou JX,
|
||
Zhao WJ,
|
||
Dai WY,
|
||
Zhu J,
|
||
Li ZH</span><br />
|
||
<span class="medgenPMjournal">Eur J Surg Oncol</span>
|
||
2017 Dec;43(12):2248-2256.
|
||
Epub 2017 Sep 12
|
||
doi: 10.1016/j.ejso.2017.09.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28942234" target="_blank">28942234</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20cancer%2C%20nonmedullary%2C%202%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4632)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38426403">Spatial transcriptomics reveals prognosis-associated cellular heterogeneity in the papillary thyroid carcinoma microenvironment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yan K,
|
||
Liu QZ,
|
||
Huang RR,
|
||
Jiang YH,
|
||
Bian ZH,
|
||
Li SJ,
|
||
Li L,
|
||
Shen F,
|
||
Tsuneyama K,
|
||
Zhang QL,
|
||
Lian ZX,
|
||
Guan H,
|
||
Xu B</span><br />
|
||
<span class="medgenPMjournal">Clin Transl Med</span>
|
||
2024 Mar;14(3):e1594.
|
||
doi: 10.1002/ctm2.1594.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38426403" target="_blank">38426403</a><a href="/pmc/articles/PMC10905537" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37916932">Risk stratification of papillary thyroid cancers using multidimensional machine learning.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Wu F,
|
||
Ge W,
|
||
Zhang Y,
|
||
Hu Y,
|
||
Zhao L,
|
||
Gou W,
|
||
Shi J,
|
||
Ni Y,
|
||
Li L,
|
||
Fu W,
|
||
Lin X,
|
||
Yu Y,
|
||
Han Z,
|
||
Chen C,
|
||
Xu R,
|
||
Zhang S,
|
||
Zhou L,
|
||
Pan G,
|
||
Peng Y,
|
||
Mao L,
|
||
Zhou T,
|
||
Zheng J,
|
||
Zheng H,
|
||
Sun Y,
|
||
Guo T,
|
||
Luo D</span><br />
|
||
<span class="medgenPMjournal">Int J Surg</span>
|
||
2024 Jan 1;110(1):372-384.
|
||
doi: 10.1097/JS9.0000000000000814.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37916932" target="_blank">37916932</a><a href="/pmc/articles/PMC10793787" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30911279">Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abdullah MI,
|
||
Junit SM,
|
||
Ng KL,
|
||
Jayapalan JJ,
|
||
Karikalan B,
|
||
Hashim OH</span><br />
|
||
<span class="medgenPMjournal">Int J Med Sci</span>
|
||
2019;16(3):450-460.
|
||
Epub 2019 Feb 28
|
||
doi: 10.7150/ijms.29935.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30911279" target="_blank">30911279</a><a href="/pmc/articles/PMC6428975" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30844924">Papillary microcarcinoma of the thyroid gland: current controversies and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rovira A,
|
||
Nixon IJ,
|
||
Simo R</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Otolaryngol Head Neck Surg</span>
|
||
2019 Apr;27(2):110-116.
|
||
doi: 10.1097/MOO.0000000000000520.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30844924" target="_blank">30844924</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30747050">Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ibrahimpasic T,
|
||
Ghossein R,
|
||
Shah JP,
|
||
Ganly I</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2019 Mar;29(3):311-321.
|
||
doi: 10.1089/thy.2018.0509.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30747050" target="_blank">30747050</a><a href="/pmc/articles/PMC6437626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20cancer%2C%20nonmedullary%2C%202%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3735)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38453274">Combination of Dabrafenib and Trametinib in Patients with Metastatic BRAFV600E-Mutated Thyroid Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jeon Y,
|
||
Park S,
|
||
Lee SH,
|
||
Kim TH,
|
||
Kim SW,
|
||
Ahn MJ,
|
||
Jung HA,
|
||
Chung JH</span><br />
|
||
<span class="medgenPMjournal">Cancer Res Treat</span>
|
||
2024 Oct;56(4):1270-1276.
|
||
Epub 2024 Mar 6
|
||
doi: 10.4143/crt.2023.1278.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38453274" target="_blank">38453274</a><a href="/pmc/articles/PMC11491250" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36449303">Comparison of Lobectomy vs Total Thyroidectomy for Intermediate-Risk Papillary Thyroid Carcinoma With Lymph Node Metastasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xu S,
|
||
Huang H,
|
||
Huang Y,
|
||
Qian J,
|
||
Wang X,
|
||
Xu Z,
|
||
Liu S,
|
||
Liu J</span><br />
|
||
<span class="medgenPMjournal">JAMA Surg</span>
|
||
2023 Jan 1;158(1):73-79.
|
||
doi: 10.1001/jamasurg.2022.5781.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36449303" target="_blank">36449303</a><a href="/pmc/articles/PMC9713681" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36326739">American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gordon AJ,
|
||
Dublin JC,
|
||
Patel E,
|
||
Papazian M,
|
||
Chow MS,
|
||
Persky MJ,
|
||
Jacobson AS,
|
||
Patel KN,
|
||
Suh I,
|
||
Morris LGT,
|
||
Givi B</span><br />
|
||
<span class="medgenPMjournal">JAMA Otolaryngol Head Neck Surg</span>
|
||
2022 Dec 1;148(12):1156-1163.
|
||
doi: 10.1001/jamaoto.2022.3360.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36326739" target="_blank">36326739</a><a href="/pmc/articles/PMC9634599" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35333737">Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Waguespack SG,
|
||
Drilon A,
|
||
Lin JJ,
|
||
Brose MS,
|
||
McDermott R,
|
||
Almubarak M,
|
||
Bauman J,
|
||
Casanova M,
|
||
Krishnamurthy A,
|
||
Kummar S,
|
||
Leyvraz S,
|
||
Oh DY,
|
||
Park K,
|
||
Sohal D,
|
||
Sherman E,
|
||
Norenberg R,
|
||
Silvertown JD,
|
||
Brega N,
|
||
Hong DS,
|
||
Cabanillas ME</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2022 Apr 29;186(6):631-643.
|
||
doi: 10.1530/EJE-21-1259.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35333737" target="_blank">35333737</a><a href="/pmc/articles/PMC9066591" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34237031">NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee YA,
|
||
Lee H,
|
||
Im SW,
|
||
Song YS,
|
||
Oh DY,
|
||
Kang HJ,
|
||
Won JK,
|
||
Jung KC,
|
||
Kwon D,
|
||
Chung EJ,
|
||
Hah JH,
|
||
Paeng JC,
|
||
Kim JH,
|
||
Choi J,
|
||
Kim OH,
|
||
Oh JM,
|
||
Ahn BC,
|
||
Wirth LJ,
|
||
Shin CH,
|
||
Kim JI,
|
||
Park YJ</span><br />
|
||
<span class="medgenPMjournal">J Clin Invest</span>
|
||
2021 Sep 15;131(18)
|
||
doi: 10.1172/JCI144847.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34237031" target="_blank">34237031</a><a href="/pmc/articles/PMC8439610" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20cancer%2C%20nonmedullary%2C%202%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1618)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37916932">Risk stratification of papillary thyroid cancers using multidimensional machine learning.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Wu F,
|
||
Ge W,
|
||
Zhang Y,
|
||
Hu Y,
|
||
Zhao L,
|
||
Gou W,
|
||
Shi J,
|
||
Ni Y,
|
||
Li L,
|
||
Fu W,
|
||
Lin X,
|
||
Yu Y,
|
||
Han Z,
|
||
Chen C,
|
||
Xu R,
|
||
Zhang S,
|
||
Zhou L,
|
||
Pan G,
|
||
Peng Y,
|
||
Mao L,
|
||
Zhou T,
|
||
Zheng J,
|
||
Zheng H,
|
||
Sun Y,
|
||
Guo T,
|
||
Luo D</span><br />
|
||
<span class="medgenPMjournal">Int J Surg</span>
|
||
2024 Jan 1;110(1):372-384.
|
||
doi: 10.1097/JS9.0000000000000814.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37916932" target="_blank">37916932</a><a href="/pmc/articles/PMC10793787" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35132899">Thyroid Cancer Incidence and Mortality Trends in the United States: 2000-2018.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Megwalu UC,
|
||
Moon PK</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2022 May;32(5):560-570.
|
||
Epub 2022 Mar 15
|
||
doi: 10.1089/thy.2021.0662.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35132899" target="_blank">35132899</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32477264">Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mao J,
|
||
Zhang Q,
|
||
Zhang H,
|
||
Zheng K,
|
||
Wang R,
|
||
Wang G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:265.
|
||
Epub 2020 May 15
|
||
doi: 10.3389/fendo.2020.00265.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32477264" target="_blank">32477264</a><a href="/pmc/articles/PMC7242632" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30911279">Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abdullah MI,
|
||
Junit SM,
|
||
Ng KL,
|
||
Jayapalan JJ,
|
||
Karikalan B,
|
||
Hashim OH</span><br />
|
||
<span class="medgenPMjournal">Int J Med Sci</span>
|
||
2019;16(3):450-460.
|
||
Epub 2019 Feb 28
|
||
doi: 10.7150/ijms.29935.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30911279" target="_blank">30911279</a><a href="/pmc/articles/PMC6428975" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30747050">Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ibrahimpasic T,
|
||
Ghossein R,
|
||
Shah JP,
|
||
Ganly I</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2019 Mar;29(3):311-321.
|
||
doi: 10.1089/thy.2018.0509.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30747050" target="_blank">30747050</a><a href="/pmc/articles/PMC6437626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20cancer%2C%20nonmedullary%2C%202%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3592)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38426403">Spatial transcriptomics reveals prognosis-associated cellular heterogeneity in the papillary thyroid carcinoma microenvironment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yan K,
|
||
Liu QZ,
|
||
Huang RR,
|
||
Jiang YH,
|
||
Bian ZH,
|
||
Li SJ,
|
||
Li L,
|
||
Shen F,
|
||
Tsuneyama K,
|
||
Zhang QL,
|
||
Lian ZX,
|
||
Guan H,
|
||
Xu B</span><br />
|
||
<span class="medgenPMjournal">Clin Transl Med</span>
|
||
2024 Mar;14(3):e1594.
|
||
doi: 10.1002/ctm2.1594.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38426403" target="_blank">38426403</a><a href="/pmc/articles/PMC10905537" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37916932">Risk stratification of papillary thyroid cancers using multidimensional machine learning.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Wu F,
|
||
Ge W,
|
||
Zhang Y,
|
||
Hu Y,
|
||
Zhao L,
|
||
Gou W,
|
||
Shi J,
|
||
Ni Y,
|
||
Li L,
|
||
Fu W,
|
||
Lin X,
|
||
Yu Y,
|
||
Han Z,
|
||
Chen C,
|
||
Xu R,
|
||
Zhang S,
|
||
Zhou L,
|
||
Pan G,
|
||
Peng Y,
|
||
Mao L,
|
||
Zhou T,
|
||
Zheng J,
|
||
Zheng H,
|
||
Sun Y,
|
||
Guo T,
|
||
Luo D</span><br />
|
||
<span class="medgenPMjournal">Int J Surg</span>
|
||
2024 Jan 1;110(1):372-384.
|
||
doi: 10.1097/JS9.0000000000000814.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37916932" target="_blank">37916932</a><a href="/pmc/articles/PMC10793787" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36546348">Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee JS,
|
||
Lee JS,
|
||
Yun HJ,
|
||
Kim SM,
|
||
Chang H,
|
||
Lee YS,
|
||
Chang HS,
|
||
Park CS</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2023 May 17;108(6):1370-1375.
|
||
doi: 10.1210/clinem/dgac739.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36546348" target="_blank">36546348</a><a href="/pmc/articles/PMC10188299" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32477264">Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mao J,
|
||
Zhang Q,
|
||
Zhang H,
|
||
Zheng K,
|
||
Wang R,
|
||
Wang G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:265.
|
||
Epub 2020 May 15
|
||
doi: 10.3389/fendo.2020.00265.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32477264" target="_blank">32477264</a><a href="/pmc/articles/PMC7242632" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30747050">Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ibrahimpasic T,
|
||
Ghossein R,
|
||
Shah JP,
|
||
Ganly I</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2019 Mar;29(3):311-321.
|
||
doi: 10.1089/thy.2018.0509.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30747050" target="_blank">30747050</a><a href="/pmc/articles/PMC6437626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20cancer%2C%20nonmedullary%2C%202%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2868)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38018310">Glucagon-like peptide-1 receptor agonists and risk of thyroid cancer: A systematic review and meta-analysis of randomized controlled trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Silverii GA,
|
||
Monami M,
|
||
Gallo M,
|
||
Ragni A,
|
||
Prattichizzo F,
|
||
Renzelli V,
|
||
Ceriello A,
|
||
Mannucci E</span><br />
|
||
<span class="medgenPMjournal">Diabetes Obes Metab</span>
|
||
2024 Mar;26(3):891-900.
|
||
Epub 2023 Nov 29
|
||
doi: 10.1111/dom.15382.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38018310" target="_blank">38018310</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37604507">Efficacy and safety of ultrasound-guided radiofrequency, microwave and laser ablation for the treatment of T1N0M0 papillary thyroid carcinoma on a large scale: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gao X,
|
||
Yang Y,
|
||
Wang Y,
|
||
Huang Y</span><br />
|
||
<span class="medgenPMjournal">Int J Hyperthermia</span>
|
||
2023 Dec;40(1):2244713.
|
||
doi: 10.1080/02656736.2023.2244713.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37604507" target="_blank">37604507</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35647194">Risk and Prognostic Factors for BRAF(V600E) Mutations in Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wei X,
|
||
Wang X,
|
||
Xiong J,
|
||
Li C,
|
||
Liao Y,
|
||
Zhu Y,
|
||
Mao J</span><br />
|
||
<span class="medgenPMjournal">Biomed Res Int</span>
|
||
2022;2022:9959649.
|
||
Epub 2022 May 18
|
||
doi: 10.1155/2022/9959649.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35647194" target="_blank">35647194</a><a href="/pmc/articles/PMC9132653" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35142816">Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Dijk SPJ,
|
||
Coerts HI,
|
||
Gunput STG,
|
||
van Velsen EFS,
|
||
Medici M,
|
||
Moelker A,
|
||
Peeters RP,
|
||
Verhoef C,
|
||
van Ginhoven TM</span><br />
|
||
<span class="medgenPMjournal">JAMA Otolaryngol Head Neck Surg</span>
|
||
2022 Apr 1;148(4):317-325.
|
||
doi: 10.1001/jamaoto.2021.4381.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35142816" target="_blank">35142816</a><a href="/pmc/articles/PMC8832309" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32477264">Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mao J,
|
||
Zhang Q,
|
||
Zhang H,
|
||
Zheng K,
|
||
Wang R,
|
||
Wang G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:265.
|
||
Epub 2020 May 15
|
||
doi: 10.3389/fendo.2020.00265.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32477264" target="_blank">32477264</a><a href="/pmc/articles/PMC7242632" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20cancer%2C%20nonmedullary%2C%202%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (138)</a></div></div>
|
||
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|
||
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|
||
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|
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|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4225426%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (64)</a></li>
|
||
<li><a href="/gtr/tests?term=C4225426%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C4225426%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C4225426%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (82)</a></li>
|
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<li><a href="/gtr/tests?term=C4225426%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (12)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C4225426%5bDISCUI%5d" target="_blank">See all (92)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=188470" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Thyroid%20cancer,%20nonmedullary,%202" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(thyroid%20cancer%2C%20nonmedullary%2C%202)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Thyroid%20cancer%2C%20nonmedullary%2C%202%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng230">NICE, 2022</a><div>UK NICE Guideline NG230, Thyroid cancer: assessment and management</div></li><li><a target="_blank" href="https://www.cms.gov/Medicare/Coverage/DeterminationProcess/downloads/id90TA.pdf">AHRQ, 2013</a><div>Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)</div></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=164790%20190020%20605391%20606523" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=3265[geneid]" target="_blank">View HRAS variations in ClinVar</a></li><li><a href="/clinvar/?term=4893[geneid]" target="_blank">View NRAS variations in ClinVar</a></li><li><a href="/clinvar/?term=9562[geneid]" target="_blank">View MINPP1 variations in ClinVar</a></li><li><a href="/clinvar/?term=57522[geneid]" target="_blank">View SRGAP1 variations in ClinVar</a></li><li><a href="/nuccore/187423895,187960074,260593668" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=188470" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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