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<meta name="keywords" content="C4021591, finding, hepatic ductopenia, intrahepatic duct deficiency, reduced number of intrahepatic bile ducts, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The presence of reduced numbers of intrahepatic bile duct than normal." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Reduced number of intrahepatic bile ducts (Concept Id: C4021591)
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<!--
|
||
UID=892333
|
||
ConceptID=C4021591
|
||
-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Reduced number of intrahepatic bile ducts</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>892333</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4021591</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Hepatic ductopenia; Intrahepatic duct deficiency</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006571">HP:0006571</a></td></tr>
|
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">The presence of reduced numbers of intrahepatic bile duct than normal. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_118">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Reduced number of intrahepatic bile ducts</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867396" ref="tree=MeSH" title="MedGen record for Abnormality of the abdominal organs">Abnormality of the abdominal organs</a></span><ul><li><span class="TLline"><a href="/medgen/893061" ref="tree=MeSH" title="MedGen record for Abnormality of the liver">Abnormality of the liver</a></span><ul><li><span class="TLline"><a href="/medgen/184895" ref="tree=MeSH" title="MedGen record for Abnormality of the biliary system">Abnormality of the biliary system</a></span><ul><li><span class="TLline"><a href="/medgen/108201" ref="tree=MeSH" title="MedGen record for Biliary tract abnormality">Biliary tract abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/866739" ref="tree=MeSH" title="MedGen record for Abnormal biliary tract morphology">Abnormal biliary tract morphology</a></span><ul><li><span class="TLline"><a href="/medgen/869157" ref="tree=MeSH" title="MedGen record for Abnormal intrahepatic bile duct morphology">Abnormal intrahepatic bile duct morphology</a></span><ul><li><span class="matched_ds">Reduced number of intrahepatic bile ducts</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_365434"><div><strong>Alagille syndrome due to a JAG1 point mutation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>365434</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1956125</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Alagille syndrome (ALGS) is a multisystem disorder with a wide spectrum of clinical variability; this variability is seen even among individuals from the same family. The major clinical manifestations of ALGS are bile duct paucity on liver biopsy, cholestasis, congenital cardiac defects (primarily involving the pulmonary arteries), butterfly vertebrae, ophthalmologic abnormalities (most commonly posterior embryotoxon), and characteristic facial features. Renal abnormalities, growth failure, behavioral differences, splenomegaly, retinal changes, and vascular abnormalities may also occur.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/365434">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766918"><div><strong>Peroxisome biogenesis disorder 13A (Zellweger)</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766918</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554004</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Zellweger syndrome (ZS) is an autosomal recessive multiple congenital anomaly syndrome resulting from disordered peroxisome biogenesis. Affected children present in the newborn period with profound hypotonia, seizures, and inability to feed. Characteristic craniofacial anomalies, eye abnormalities, neuronal migration defects, hepatomegaly, and chondrodysplasia punctata are present. Children with this condition do not show any significant development and usually die in the first year of life (summary by Steinberg et al., 2006). For a complete phenotypic description and a discussion of genetic heterogeneity of Zellweger syndrome, see 214100. Individuals with PBDs of complementation group K (CGK) have mutations in the PEX14 gene. For information on the history of PBD complementation groups, see 214100.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766918">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_365434" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alagille syndrome due to a JAG1 point mutation</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766918" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Peroxisome biogenesis disorder 13A (Zellweger)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39223811">Study of Risk Factors Associated With Recurrent Primary Sclerosing Cholangitis After Liver Transplantation in Shiraz >From 2011 to 2021.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Taghavi SA,
|
||
Safarpour AR,
|
||
Ghahramani S,
|
||
Moghadam SM,
|
||
Shahramian I,
|
||
Sivandzadeh GR,
|
||
Nikeghbalian S,
|
||
Tahani M,
|
||
Saeian S,
|
||
Malek-Hosseini SA</span><br />
|
||
<span class="medgenPMjournal">Exp Clin Transplant</span>
|
||
2024 Jul;22(7):531-539.
|
||
doi: 10.6002/ect.2024.0085.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39223811" target="_blank">39223811</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38571480">Emerging drugs for the treatment of progressive familial intrahepatic cholestasis: a focus on phase II and III trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hof WFJ,
|
||
de Boer JF,
|
||
Verkade HJ</span><br />
|
||
<span class="medgenPMjournal">Expert Opin Emerg Drugs</span>
|
||
2024 Sep;29(3):305-320.
|
||
Epub 2024 Jul 4
|
||
doi: 10.1080/14728214.2024.2336986.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38571480" target="_blank">38571480</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36535198">Nanoparticle-mediated therapeutic management in cholangiocarcinoma drug targeting: Current progress and future prospects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu C,
|
||
Wu K,
|
||
Li J,
|
||
Mu X,
|
||
Gao H,
|
||
Xu X</span><br />
|
||
<span class="medgenPMjournal">Biomed Pharmacother</span>
|
||
2023 Feb;158:114135.
|
||
Epub 2022 Dec 17
|
||
doi: 10.1016/j.biopha.2022.114135.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36535198" target="_blank">36535198</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(reduced%20number%20of%20intrahepatic%20bile%20ducts)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (9)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38571480">Emerging drugs for the treatment of progressive familial intrahepatic cholestasis: a focus on phase II and III trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hof WFJ,
|
||
de Boer JF,
|
||
Verkade HJ</span><br />
|
||
<span class="medgenPMjournal">Expert Opin Emerg Drugs</span>
|
||
2024 Sep;29(3):305-320.
|
||
Epub 2024 Jul 4
|
||
doi: 10.1080/14728214.2024.2336986.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38571480" target="_blank">38571480</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36404249">Prognostic value of lymphadenectomy in node-negative intrahepatic cholangiocarcinoma: A multicenter, retrospectively study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen C,
|
||
Su J,
|
||
Wu H,
|
||
Qiu Y,
|
||
Song T,
|
||
Mao X,
|
||
He Y,
|
||
Cheng Z,
|
||
Zhai W,
|
||
Li J,
|
||
Geng Z,
|
||
Tang Z</span><br />
|
||
<span class="medgenPMjournal">Eur J Surg Oncol</span>
|
||
2023 Apr;49(4):780-787.
|
||
Epub 2022 Nov 8
|
||
doi: 10.1016/j.ejso.2022.11.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36404249" target="_blank">36404249</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35853232">Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin Y,
|
||
Peng L,
|
||
Dong L,
|
||
Liu D,
|
||
Ma J,
|
||
Lin J,
|
||
Chen X,
|
||
Lin P,
|
||
Song G,
|
||
Zhang M,
|
||
Liu Y,
|
||
Rao J,
|
||
Wei C,
|
||
Lu Y,
|
||
Zhang S,
|
||
Ding G,
|
||
Peng Z,
|
||
Lu H,
|
||
Wang X,
|
||
Zhou J,
|
||
Fan J,
|
||
Wu K,
|
||
Gao Q</span><br />
|
||
<span class="medgenPMjournal">Cancer Discov</span>
|
||
2022 Oct 5;12(10):2350-2371.
|
||
doi: 10.1158/2159-8290.CD-21-1640.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35853232" target="_blank">35853232</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35701586">Association of the presence of allergic disease with subsequent risk of liver cancer in a nationwide retrospective cohort among Koreans.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim JA,
|
||
Park SJ,
|
||
Choi S,
|
||
Chang J,
|
||
Jeong S,
|
||
C Ahn J,
|
||
Lee G,
|
||
Son JS,
|
||
Park SM</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Jun 14;12(1):9856.
|
||
doi: 10.1038/s41598-022-14147-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35701586" target="_blank">35701586</a><a href="/pmc/articles/PMC9198066" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34626299">Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sakano Y,
|
||
Noda T,
|
||
Kobayashi S,
|
||
Kitagawa A,
|
||
Iwagami Y,
|
||
Yamada D,
|
||
Tomimaru Y,
|
||
Akita H,
|
||
Gotoh K,
|
||
Asaoka T,
|
||
Tanemura M,
|
||
Umeshita K,
|
||
Mimori K,
|
||
Doki Y,
|
||
Eguchi H</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2022 Aug;67(8):3817-3830.
|
||
Epub 2021 Oct 9
|
||
doi: 10.1007/s10620-021-07266-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34626299" target="_blank">34626299</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20number%20of%20intrahepatic%20bile%20ducts%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (42)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36535198">Nanoparticle-mediated therapeutic management in cholangiocarcinoma drug targeting: Current progress and future prospects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu C,
|
||
Wu K,
|
||
Li J,
|
||
Mu X,
|
||
Gao H,
|
||
Xu X</span><br />
|
||
<span class="medgenPMjournal">Biomed Pharmacother</span>
|
||
2023 Feb;158:114135.
|
||
Epub 2022 Dec 17
|
||
doi: 10.1016/j.biopha.2022.114135.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36535198" target="_blank">36535198</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35701586">Association of the presence of allergic disease with subsequent risk of liver cancer in a nationwide retrospective cohort among Koreans.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim JA,
|
||
Park SJ,
|
||
Choi S,
|
||
Chang J,
|
||
Jeong S,
|
||
C Ahn J,
|
||
Lee G,
|
||
Son JS,
|
||
Park SM</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Jun 14;12(1):9856.
|
||
doi: 10.1038/s41598-022-14147-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35701586" target="_blank">35701586</a><a href="/pmc/articles/PMC9198066" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34626299">Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sakano Y,
|
||
Noda T,
|
||
Kobayashi S,
|
||
Kitagawa A,
|
||
Iwagami Y,
|
||
Yamada D,
|
||
Tomimaru Y,
|
||
Akita H,
|
||
Gotoh K,
|
||
Asaoka T,
|
||
Tanemura M,
|
||
Umeshita K,
|
||
Mimori K,
|
||
Doki Y,
|
||
Eguchi H</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2022 Aug;67(8):3817-3830.
|
||
Epub 2021 Oct 9
|
||
doi: 10.1007/s10620-021-07266-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34626299" target="_blank">34626299</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21301864">Ductal plates in hepatic ductular reactions. Hypothesis and implications. III. Implications for liver pathology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desmet VJ</span><br />
|
||
<span class="medgenPMjournal">Virchows Arch</span>
|
||
2011 Mar;458(3):271-9.
|
||
Epub 2011 Feb 8
|
||
doi: 10.1007/s00428-011-1050-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21301864" target="_blank">21301864</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6353110">Percutaneous transhepatic cholangiography.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Okuda K</span><br />
|
||
<span class="medgenPMjournal">Lab Res Methods Biol Med</span>
|
||
1983;7:405-23.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6353110" target="_blank">6353110</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20number%20of%20intrahepatic%20bile%20ducts%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38571480">Emerging drugs for the treatment of progressive familial intrahepatic cholestasis: a focus on phase II and III trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hof WFJ,
|
||
de Boer JF,
|
||
Verkade HJ</span><br />
|
||
<span class="medgenPMjournal">Expert Opin Emerg Drugs</span>
|
||
2024 Sep;29(3):305-320.
|
||
Epub 2024 Jul 4
|
||
doi: 10.1080/14728214.2024.2336986.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38571480" target="_blank">38571480</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36999529">A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caballero-Camino FJ,
|
||
Rodrigues PM,
|
||
Wångsell F,
|
||
Agirre-Lizaso A,
|
||
Olaizola P,
|
||
Izquierdo-Sanchez L,
|
||
Perugorria MJ,
|
||
Bujanda L,
|
||
Angelin B,
|
||
Straniero S,
|
||
Wallebäck A,
|
||
Starke I,
|
||
Gillberg PG,
|
||
Strängberg E,
|
||
Bonn B,
|
||
Mattsson JP,
|
||
Madsen MR,
|
||
Hansen HH,
|
||
Lindström E,
|
||
Åkerblad P,
|
||
Banales JM</span><br />
|
||
<span class="medgenPMjournal">Hepatology</span>
|
||
2023 Sep 1;78(3):709-726.
|
||
Epub 2023 Apr 1
|
||
doi: 10.1097/HEP.0000000000000376.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36999529" target="_blank">36999529</a><a href="/pmc/articles/PMC10442107" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36700218">Conversion therapy for advanced intrahepatic cholangiocarcinoma with lenvatinib and pembrolizumab combined with gemcitabine plus cisplatin: A case report and literature review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang W,
|
||
Luo C,
|
||
Zhang ZY,
|
||
Zhang BX,
|
||
Chen XP</span><br />
|
||
<span class="medgenPMjournal">Front Immunol</span>
|
||
2022;13:1079342.
|
||
Epub 2023 Jan 9
|
||
doi: 10.3389/fimmu.2022.1079342.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36700218" target="_blank">36700218</a><a href="/pmc/articles/PMC9868150" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35839109">Analysis of EBN Interventions in the Perioperative Period of Minimally Invasive Surgery for Intrahepatic and Extrahepatic Bile Duct Stones.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang Y,
|
||
Qiu J,
|
||
Zhu L</span><br />
|
||
<span class="medgenPMjournal">Altern Ther Health Med</span>
|
||
2022 Oct;28(7):139-145.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35839109" target="_blank">35839109</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6353110">Percutaneous transhepatic cholangiography.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Okuda K</span><br />
|
||
<span class="medgenPMjournal">Lab Res Methods Biol Med</span>
|
||
1983;7:405-23.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6353110" target="_blank">6353110</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20number%20of%20intrahepatic%20bile%20ducts%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (24)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38641672">The histone lysine acetyltransferase KAT2B inhibits cholangiocarcinoma growth: evidence for interaction with SP1 to regulate NF2-YAP signaling.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ma W,
|
||
Zhang J,
|
||
Chen W,
|
||
Liu N,
|
||
Wu T</span><br />
|
||
<span class="medgenPMjournal">J Exp Clin Cancer Res</span>
|
||
2024 Apr 19;43(1):117.
|
||
doi: 10.1186/s13046-024-03036-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38641672" target="_blank">38641672</a><a href="/pmc/articles/PMC11027350" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36535198">Nanoparticle-mediated therapeutic management in cholangiocarcinoma drug targeting: Current progress and future prospects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu C,
|
||
Wu K,
|
||
Li J,
|
||
Mu X,
|
||
Gao H,
|
||
Xu X</span><br />
|
||
<span class="medgenPMjournal">Biomed Pharmacother</span>
|
||
2023 Feb;158:114135.
|
||
Epub 2022 Dec 17
|
||
doi: 10.1016/j.biopha.2022.114135.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36535198" target="_blank">36535198</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36404249">Prognostic value of lymphadenectomy in node-negative intrahepatic cholangiocarcinoma: A multicenter, retrospectively study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen C,
|
||
Su J,
|
||
Wu H,
|
||
Qiu Y,
|
||
Song T,
|
||
Mao X,
|
||
He Y,
|
||
Cheng Z,
|
||
Zhai W,
|
||
Li J,
|
||
Geng Z,
|
||
Tang Z</span><br />
|
||
<span class="medgenPMjournal">Eur J Surg Oncol</span>
|
||
2023 Apr;49(4):780-787.
|
||
Epub 2022 Nov 8
|
||
doi: 10.1016/j.ejso.2022.11.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36404249" target="_blank">36404249</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35853232">Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin Y,
|
||
Peng L,
|
||
Dong L,
|
||
Liu D,
|
||
Ma J,
|
||
Lin J,
|
||
Chen X,
|
||
Lin P,
|
||
Song G,
|
||
Zhang M,
|
||
Liu Y,
|
||
Rao J,
|
||
Wei C,
|
||
Lu Y,
|
||
Zhang S,
|
||
Ding G,
|
||
Peng Z,
|
||
Lu H,
|
||
Wang X,
|
||
Zhou J,
|
||
Fan J,
|
||
Wu K,
|
||
Gao Q</span><br />
|
||
<span class="medgenPMjournal">Cancer Discov</span>
|
||
2022 Oct 5;12(10):2350-2371.
|
||
doi: 10.1158/2159-8290.CD-21-1640.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35853232" target="_blank">35853232</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34626299">Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sakano Y,
|
||
Noda T,
|
||
Kobayashi S,
|
||
Kitagawa A,
|
||
Iwagami Y,
|
||
Yamada D,
|
||
Tomimaru Y,
|
||
Akita H,
|
||
Gotoh K,
|
||
Asaoka T,
|
||
Tanemura M,
|
||
Umeshita K,
|
||
Mimori K,
|
||
Doki Y,
|
||
Eguchi H</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2022 Aug;67(8):3817-3830.
|
||
Epub 2021 Oct 9
|
||
doi: 10.1007/s10620-021-07266-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34626299" target="_blank">34626299</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20number%20of%20intrahepatic%20bile%20ducts%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (29)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36404249">Prognostic value of lymphadenectomy in node-negative intrahepatic cholangiocarcinoma: A multicenter, retrospectively study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen C,
|
||
Su J,
|
||
Wu H,
|
||
Qiu Y,
|
||
Song T,
|
||
Mao X,
|
||
He Y,
|
||
Cheng Z,
|
||
Zhai W,
|
||
Li J,
|
||
Geng Z,
|
||
Tang Z</span><br />
|
||
<span class="medgenPMjournal">Eur J Surg Oncol</span>
|
||
2023 Apr;49(4):780-787.
|
||
Epub 2022 Nov 8
|
||
doi: 10.1016/j.ejso.2022.11.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36404249" target="_blank">36404249</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36331963">Effectiveness of ultrasound-guided percutaneous transhepatic biliary drainage to reduce radiation exposure: A single-center experience.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Park SE,
|
||
Nam IC,
|
||
Baek HJ,
|
||
Ryu KH,
|
||
Lim SG,
|
||
Won JH,
|
||
Kim DR</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2022;17(11):e0277272.
|
||
Epub 2022 Nov 4
|
||
doi: 10.1371/journal.pone.0277272.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36331963" target="_blank">36331963</a><a href="/pmc/articles/PMC9635691" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35839109">Analysis of EBN Interventions in the Perioperative Period of Minimally Invasive Surgery for Intrahepatic and Extrahepatic Bile Duct Stones.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang Y,
|
||
Qiu J,
|
||
Zhu L</span><br />
|
||
<span class="medgenPMjournal">Altern Ther Health Med</span>
|
||
2022 Oct;28(7):139-145.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35839109" target="_blank">35839109</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35740979">Cannabidiol and Cannabigerol Inhibit Cholangiocarcinoma Growth In Vitro via Divergent Cell Death Pathways.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Viereckl MJ,
|
||
Krutsinger K,
|
||
Apawu A,
|
||
Gu J,
|
||
Cardona B,
|
||
Barratt D,
|
||
Han Y</span><br />
|
||
<span class="medgenPMjournal">Biomolecules</span>
|
||
2022 Jun 20;12(6)
|
||
doi: 10.3390/biom12060854.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35740979" target="_blank">35740979</a><a href="/pmc/articles/PMC9221388" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
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<div class="nl"><a target="_blank" href="/pubmed/35701586">Association of the presence of allergic disease with subsequent risk of liver cancer in a nationwide retrospective cohort among Koreans.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Kim JA,
|
||
Park SJ,
|
||
Choi S,
|
||
Chang J,
|
||
Jeong S,
|
||
C Ahn J,
|
||
Lee G,
|
||
Son JS,
|
||
Park SM</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Jun 14;12(1):9856.
|
||
doi: 10.1038/s41598-022-14147-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35701586" target="_blank">35701586</a><a href="/pmc/articles/PMC9198066" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20number%20of%20intrahepatic%20bile%20ducts%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div></div>
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