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<meta name="keywords" content="C4016325, finding, plasminogen activator inhibitor i, transcription level of plasminogen activator inhibitor 1, transcription of plasminogen activator inhibitor, modulator of, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Untreated complete plasminogen activator inhibitor 1 (PAI-1) deficiency is characterized by mild-to-moderate bleeding, although in some instances bleeding can be life-threatening. Most commonly, delayed bleeding is associated with injury, trauma, or surgery; spontaneous bleeding does not occur. While males and females with complete PAI-1 deficiency are affected equally, females may present more frequently with clinical manifestations or earlier in life than males due to menorrhagia and postpartum hemorrhage. Fewer than ten families with complete PAI-1 deficiency have been reported to date. The incidence of complete PAI-1 deficiency is higher than expected in the genetic isolate of the Old Order Amish population of eastern and southern Indiana due to a pathogenic founder variant. In one family from this Old Order Amish population, seven individuals were diagnosed to have cardiac fibrosis of varying degrees." /><meta name="robots" content="index,nofollow,noarchive" />
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<div><div class="rprt full-rprt"><div class="portlet" style="border-top-style: none; margin-top: 0px; padding-top: 0px; margin-bottom: 0px; padding-left: 0.2em;">
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<!--
|
||
UID=864762
|
||
ConceptID=C4016325
|
||
-->
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||
<!--imgCountBooks = 1--><div class="ncbi_carousel" data-ncbicarousel-config="imageWidth:'100px',numItemsVisible:2,toggler:false"><div class="nc_header"><span class="img_strip_title">Image</span></div><div class="nc_content"><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK447152/bin/pai-1-def-Image001.gif" src-large="/books/NBK447152/bin/pai-1-def-Image001.jpg" /></a><br /><a href="/books/NBK447152/figure/pai-1-def.F1/" title="GeneReviews" target="_blank">details</a></div></div></div><h1 class="medgenTitle"><div class="MedGenTitleText">Transcription level of plasminogen activator inhibitor 1</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864762</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4016325</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Plasminogen Activator Inhibitor I; TRANSCRIPTION OF PLASMINOGEN ACTIVATOR INHIBITOR, MODULATOR OF</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/173360" target="_blank">173360</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK447152" target="_blank">Complete Plasminogen Activator Inhibitor 1 Deficiency</a></div><div>Untreated complete plasminogen activator inhibitor 1 (PAI-1) deficiency is characterized by mild-to-moderate bleeding, although in some instances bleeding can be life-threatening. Most commonly, delayed bleeding is associated with injury, trauma, or surgery; spontaneous bleeding does not occur. While males and females with complete PAI-1 deficiency are affected equally, females may present more frequently with clinical manifestations or earlier in life than males due to menorrhagia and postpartum hemorrhage. Fewer than ten families with complete PAI-1 deficiency have been reported to date. The incidence of complete PAI-1 deficiency is higher than expected in the genetic isolate of the Old Order Amish population of eastern and southern Indiana due to a pathogenic founder variant. In one family from this Old Order Amish population, seven individuals were diagnosed to have cardiac fibrosis of varying degrees. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Summary" target="NBK447152">Summary</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Diagnosis" target="NBK447152">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Clinical_Characteristics" target="NBK447152">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Genetically_Related_Allelic_Di" target="NBK447152">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Differential_Diagnosis" target="NBK447152">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Management" target="NBK447152">Management</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Genetic_Counseling" target="NBK447152">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Resources" target="NBK447152">Resources</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Molecular_Genetics" target="NBK447152">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.Chapter_Notes" target="NBK447152">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK447152#pai-1-def.References" target="NBK447152">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Meadow Heiman | Sweta Gupta | Magdalena Lewandowska<i>, et. al.</i> <a href="/books/NBK447152" target="NBK447152" title="NCBI Bookshelf: Complete Plasminogen Activator Inhibitor 1 Deficiency">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/24549864">Combination treatment with N-acetyl-seryl-aspartyl-lysyl-proline and tissue plasminogen activator provides potent neuroprotection in rats after stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang L,
|
||
Chopp M,
|
||
Teng H,
|
||
Ding G,
|
||
Jiang Q,
|
||
Yang XP,
|
||
Rhaleb NE,
|
||
Zhang ZG</span><br />
|
||
<span class="medgenPMjournal">Stroke</span>
|
||
2014 Apr;45(4):1108-14.
|
||
Epub 2014 Feb 18
|
||
doi: 10.1161/STROKEAHA.113.004399.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24549864" target="_blank">24549864</a><a href="/pmc/articles/PMC3966939" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9812921">Genotype-specific transcriptional regulation of PAI-1 gene by insulin, hypertriglyceridemic VLDL, and Lp(a) in transfected, cultured human endothelial cells.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grenett HE,
|
||
Benza RL,
|
||
Fless GM,
|
||
Li XN,
|
||
Davis GC,
|
||
Booyse FM</span><br />
|
||
<span class="medgenPMjournal">Arterioscler Thromb Vasc Biol</span>
|
||
1998 Nov;18(11):1803-9.
|
||
doi: 10.1161/01.atv.18.11.1803.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9812921" target="_blank">9812921</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9409314">Genotype-specific transcriptional regulation of PAI-1 expression by hypertriglyceridemic VLDL and Lp(a) in cultured human endothelial cells.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li XN,
|
||
Grenett HE,
|
||
Benza RL,
|
||
Demissie S,
|
||
Brown SL,
|
||
Tabengwa EM,
|
||
Gianturco SH,
|
||
Bradley WA,
|
||
Fless GM,
|
||
Booyse FM</span><br />
|
||
<span class="medgenPMjournal">Arterioscler Thromb Vasc Biol</span>
|
||
1997 Nov;17(11):3215-23.
|
||
doi: 10.1161/01.atv.17.11.3215.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9409314" target="_blank">9409314</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(transcription%20level%20of%20plasminogen%20activator%20inhibitor%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (7)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35628326">PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Badran M,
|
||
Gozal D</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2022 May 15;23(10)
|
||
doi: 10.3390/ijms23105516.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35628326" target="_blank">35628326</a><a href="/pmc/articles/PMC9141273" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33432099">Role of PAI-1 in hepatic steatosis and dyslipidemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Levine JA,
|
||
Oleaga C,
|
||
Eren M,
|
||
Amaral AP,
|
||
Shang M,
|
||
Lux E,
|
||
Khan SS,
|
||
Shah SJ,
|
||
Omura Y,
|
||
Pamir N,
|
||
Hay J,
|
||
Barish G,
|
||
Miyata T,
|
||
Tavori H,
|
||
Fazio S,
|
||
Vaughan DE</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2021 Jan 11;11(1):430.
|
||
doi: 10.1038/s41598-020-79948-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33432099" target="_blank">33432099</a><a href="/pmc/articles/PMC7801442" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33037393">An aberrant STAT pathway is central to COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Matsuyama T,
|
||
Kubli SP,
|
||
Yoshinaga SK,
|
||
Pfeffer K,
|
||
Mak TW</span><br />
|
||
<span class="medgenPMjournal">Cell Death Differ</span>
|
||
2020 Dec;27(12):3209-3225.
|
||
Epub 2020 Oct 9
|
||
doi: 10.1038/s41418-020-00633-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33037393" target="_blank">33037393</a><a href="/pmc/articles/PMC7545020" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28836366">Lipoteichoic acid upregulates plasminogen activator inhibitor-1 expression in parapneumonic effusions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee KL,
|
||
Chen WL,
|
||
Chen RJ,
|
||
Lai KS,
|
||
Chung CL</span><br />
|
||
<span class="medgenPMjournal">Respirology</span>
|
||
2018 Jan;23(1):89-95.
|
||
Epub 2017 Aug 23
|
||
doi: 10.1111/resp.13148.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28836366" target="_blank">28836366</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19438580">Plasminogen activator inhibitor-1 and asthma: role in the pathogenesis and molecular regulation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ma Z,
|
||
Paek D,
|
||
Oh CK</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Allergy</span>
|
||
2009 Aug;39(8):1136-44.
|
||
Epub 2009 May 5
|
||
doi: 10.1111/j.1365-2222.2009.03272.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19438580" target="_blank">19438580</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (143)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31711127">In peripartum cardiomyopathy plasminogen activator inhibitor-1 is a potential new biomarker with controversial roles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ricke-Hoch M,
|
||
Hoes MF,
|
||
Pfeffer TJ,
|
||
Schlothauer S,
|
||
Nonhoff J,
|
||
Haidari S,
|
||
Bomer N,
|
||
Scherr M,
|
||
Stapel B,
|
||
Stelling E,
|
||
Kiyan Y,
|
||
Falk C,
|
||
Haghikia A,
|
||
Binah O,
|
||
Arany Z,
|
||
Thum T,
|
||
Bauersachs J,
|
||
van der Meer P,
|
||
Hilfiker-Kleiner D</span><br />
|
||
<span class="medgenPMjournal">Cardiovasc Res</span>
|
||
2020 Sep 1;116(11):1875-1886.
|
||
doi: 10.1093/cvr/cvz300.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31711127" target="_blank">31711127</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22092038">Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Meijer CA,
|
||
Le Haen PA,
|
||
van Dijk RA,
|
||
Hira M,
|
||
Hamming JF,
|
||
van Bockel JH,
|
||
Lindeman JH</span><br />
|
||
<span class="medgenPMjournal">Clin Sci (Lond)</span>
|
||
2012 May;122(9):421-8.
|
||
doi: 10.1042/CS20110234.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22092038" target="_blank">22092038</a><a href="/pmc/articles/PMC3259695" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17609976">Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang B,
|
||
Wood IS,
|
||
Trayhurn P</span><br />
|
||
<span class="medgenPMjournal">Pflugers Arch</span>
|
||
2007 Dec;455(3):479-92.
|
||
Epub 2007 Jul 3
|
||
doi: 10.1007/s00424-007-0301-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17609976" target="_blank">17609976</a><a href="/pmc/articles/PMC2040175" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15469638">Adipokines: inflammation and the pleiotropic role of white adipose tissue.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Trayhurn P,
|
||
Wood IS</span><br />
|
||
<span class="medgenPMjournal">Br J Nutr</span>
|
||
2004 Sep;92(3):347-55.
|
||
doi: 10.1079/bjn20041213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15469638" target="_blank">15469638</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12421149">Plasminogen activator inhibitor-1 levels and polymorphisms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Francis CW</span><br />
|
||
<span class="medgenPMjournal">Arch Pathol Lab Med</span>
|
||
2002 Nov;126(11):1401-4.
|
||
doi: 10.5858/2002-126-1401-PAILAP.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12421149" target="_blank">12421149</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (61)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38703204">Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl(3) model.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jin X,
|
||
Yue X,
|
||
Huang Z,
|
||
Meng X,
|
||
Xu S,
|
||
Wu Y,
|
||
Wan Y,
|
||
Inoue A,
|
||
Narisawa M,
|
||
Hu L,
|
||
Shi GP,
|
||
Umegaki H,
|
||
Murohara T,
|
||
Lei Y,
|
||
Kuzuya M,
|
||
Cheng XW</span><br />
|
||
<span class="medgenPMjournal">Cell Mol Life Sci</span>
|
||
2024 May 4;81(1):205.
|
||
doi: 10.1007/s00018-024-05240-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38703204" target="_blank">38703204</a><a href="/pmc/articles/PMC11069486" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36168721">Plasminogen activating inhibitor-1 promotes angiogenesis in cutaneous angiosarcomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ohuchi K,
|
||
Amagai R,
|
||
Ikawa T,
|
||
Muto Y,
|
||
Roh Y,
|
||
Endo J,
|
||
Maekawa T,
|
||
Kambayashi Y,
|
||
Asano Y,
|
||
Fujimura T</span><br />
|
||
<span class="medgenPMjournal">Exp Dermatol</span>
|
||
2023 Jan;32(1):50-59.
|
||
Epub 2022 Oct 2
|
||
doi: 10.1111/exd.14681.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36168721" target="_blank">36168721</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28588076">Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-β and Cardiac Fibrosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Flevaris P,
|
||
Khan SS,
|
||
Eren M,
|
||
Schuldt AJT,
|
||
Shah SJ,
|
||
Lee DC,
|
||
Gupta S,
|
||
Shapiro AD,
|
||
Burridge PW,
|
||
Ghosh AK,
|
||
Vaughan DE</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2017 Aug 15;136(7):664-679.
|
||
Epub 2017 Jun 6
|
||
doi: 10.1161/CIRCULATIONAHA.117.028145.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28588076" target="_blank">28588076</a><a href="/pmc/articles/PMC5784400" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25840582">Oral Infections, Metabolic Inflammation, Genetics, and Cardiometabolic Diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Janket SJ,
|
||
Javaheri H,
|
||
Ackerson LK,
|
||
Ayilavarapu S,
|
||
Meurman JH</span><br />
|
||
<span class="medgenPMjournal">J Dent Res</span>
|
||
2015 Sep;94(9 Suppl):119S-27S.
|
||
Epub 2015 Apr 3
|
||
doi: 10.1177/0022034515580795.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25840582" target="_blank">25840582</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16175011">Plasminogen activator inhibitor-1 4G/5G polymorphism and efficacy of reperfusion therapy in acute myocardial infarction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sibbing D,
|
||
von Beckerath O,
|
||
von Beckerath N,
|
||
Koch W,
|
||
Mehilli J,
|
||
Schwaiger M,
|
||
Schömig A,
|
||
Kastrati A</span><br />
|
||
<span class="medgenPMjournal">Blood Coagul Fibrinolysis</span>
|
||
2005 Oct;16(7):511-5.
|
||
doi: 10.1097/01.mbc.0000186838.16551.ad.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16175011" target="_blank">16175011</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (48)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39527470">Integrating transcriptomic data and digital pathology for NRG-based prediction of prognosis and therapy response in gastric cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sun Q,
|
||
Li T,
|
||
Wei Z,
|
||
Ye Z,
|
||
Zhao X,
|
||
Jing J</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
2024 Dec;56(1):2426758.
|
||
Epub 2024 Nov 11
|
||
doi: 10.1080/07853890.2024.2426758.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39527470" target="_blank">39527470</a><a href="/pmc/articles/PMC11556273" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/39165353">Development and validation of a hypoxia- and mitochondrial dysfunction- related prognostic model based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Cui Y,
|
||
Wang Z,
|
||
Wang L,
|
||
Yu Y,
|
||
Xiong Y</span><br />
|
||
<span class="medgenPMjournal">Front Immunol</span>
|
||
2024;15:1419133.
|
||
Epub 2024 Aug 6
|
||
doi: 10.3389/fimmu.2024.1419133.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39165353" target="_blank">39165353</a><a href="/pmc/articles/PMC11333257" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37716913">TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gershoni A,
|
||
Hassin O,
|
||
Nataraj NB,
|
||
Baruch S,
|
||
Avioz-Seligman A,
|
||
Pirona AC,
|
||
Fellus-Alyagor L,
|
||
Meir Salame T,
|
||
Mukherjee S,
|
||
Mallel G,
|
||
Yarden Y,
|
||
Aylon Y,
|
||
Oren M</span><br />
|
||
<span class="medgenPMjournal">Mol Oncol</span>
|
||
2023 Dec;17(12):2675-2693.
|
||
Epub 2023 Oct 16
|
||
doi: 10.1002/1878-0261.13525.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37716913" target="_blank">37716913</a><a href="/pmc/articles/PMC10701768" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31711127">In peripartum cardiomyopathy plasminogen activator inhibitor-1 is a potential new biomarker with controversial roles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ricke-Hoch M,
|
||
Hoes MF,
|
||
Pfeffer TJ,
|
||
Schlothauer S,
|
||
Nonhoff J,
|
||
Haidari S,
|
||
Bomer N,
|
||
Scherr M,
|
||
Stapel B,
|
||
Stelling E,
|
||
Kiyan Y,
|
||
Falk C,
|
||
Haghikia A,
|
||
Binah O,
|
||
Arany Z,
|
||
Thum T,
|
||
Bauersachs J,
|
||
van der Meer P,
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Hilfiker-Kleiner D</span><br />
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2020 Sep 1;116(11):1875-1886.
|
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doi: 10.1093/cvr/cvz300.
|
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<span class="bold">PMID: </span><a href="/pubmed/31711127" target="_blank">31711127</a></div>
|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/19438580">Plasminogen activator inhibitor-1 and asthma: role in the pathogenesis and molecular regulation.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Ma Z,
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<span class="bold">PMID: </span><a href="/pubmed/19438580" target="_blank">19438580</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (65)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/39165353">Development and validation of a hypoxia- and mitochondrial dysfunction- related prognostic model based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
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Cui Y,
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Wang Z,
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Wang L,
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Yu Y,
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Xiong Y</span><br />
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<span class="medgenPMjournal">Front Immunol</span>
|
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2024;15:1419133.
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Epub 2024 Aug 6
|
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doi: 10.3389/fimmu.2024.1419133.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39165353" target="_blank">39165353</a><a href="/pmc/articles/PMC11333257" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38703204">Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl(3) model.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jin X,
|
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Yue X,
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Huang Z,
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Meng X,
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Xu S,
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Wu Y,
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Wan Y,
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Inoue A,
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Narisawa M,
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Hu L,
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Shi GP,
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Umegaki H,
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Murohara T,
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Lei Y,
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Kuzuya M,
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Cheng XW</span><br />
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<span class="medgenPMjournal">Cell Mol Life Sci</span>
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2024 May 4;81(1):205.
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doi: 10.1007/s00018-024-05240-0.
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<span class="bold">PMID: </span><a href="/pubmed/38703204" target="_blank">38703204</a><a href="/pmc/articles/PMC11069486" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37716913">TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gershoni A,
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Hassin O,
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Nataraj NB,
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Baruch S,
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Avioz-Seligman A,
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Pirona AC,
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Fellus-Alyagor L,
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Meir Salame T,
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Mukherjee S,
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Mallel G,
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Yarden Y,
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Aylon Y,
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Oren M</span><br />
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<span class="medgenPMjournal">Mol Oncol</span>
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2023 Dec;17(12):2675-2693.
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Epub 2023 Oct 16
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doi: 10.1002/1878-0261.13525.
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<span class="bold">PMID: </span><a href="/pubmed/37716913" target="_blank">37716913</a><a href="/pmc/articles/PMC10701768" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34187551">Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McCartney DL,
|
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Min JL,
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Richmond RC,
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Lu AT,
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Sobczyk MK,
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Davies G,
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Broer L,
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Guo X,
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Jeong A,
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Jung J,
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Kasela S,
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Katrinli S,
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Kuo PL,
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Matias-Garcia PR,
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Mishra PP,
|
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Nygaard M,
|
||
Palviainen T,
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Patki A,
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Raffield LM,
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Ratliff SM,
|
||
Richardson TG,
|
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Robinson O,
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Soerensen M,
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||
Sun D,
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||
Tsai PC,
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||
van der Zee MD,
|
||
Walker RM,
|
||
Wang X,
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||
Wang Y,
|
||
Xia R,
|
||
Xu Z,
|
||
Yao J,
|
||
Zhao W,
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||
Correa A,
|
||
Boerwinkle E,
|
||
Dugué PA,
|
||
Durda P,
|
||
Elliott HR,
|
||
Gieger C;
|
||
Genetics of DNA Methylation Consortium,
|
||
de Geus EJC,
|
||
Harris SE,
|
||
Hemani G,
|
||
Imboden M,
|
||
Kähönen M,
|
||
Kardia SLR,
|
||
Kresovich JK,
|
||
Li S,
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||
Lunetta KL,
|
||
Mangino M,
|
||
Mason D,
|
||
McIntosh AM,
|
||
Mengel-From J,
|
||
Moore AZ,
|
||
Murabito JM;
|
||
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,
|
||
Ollikainen M,
|
||
Pankow JS,
|
||
Pedersen NL,
|
||
Peters A,
|
||
Polidoro S,
|
||
Porteous DJ,
|
||
Raitakari O,
|
||
Rich SS,
|
||
Sandler DP,
|
||
Sillanpää E,
|
||
Smith AK,
|
||
Southey MC,
|
||
Strauch K,
|
||
Tiwari H,
|
||
Tanaka T,
|
||
Tillin T,
|
||
Uitterlinden AG,
|
||
Van Den Berg DJ,
|
||
van Dongen J,
|
||
Wilson JG,
|
||
Wright J,
|
||
Yet I,
|
||
Arnett D,
|
||
Bandinelli S,
|
||
Bell JT,
|
||
Binder AM,
|
||
Boomsma DI,
|
||
Chen W,
|
||
Christensen K,
|
||
Conneely KN,
|
||
Elliott P,
|
||
Ferrucci L,
|
||
Fornage M,
|
||
Hägg S,
|
||
Hayward C,
|
||
Irvin M,
|
||
Kaprio J,
|
||
Lawlor DA,
|
||
Lehtimäki T,
|
||
Lohoff FW,
|
||
Milani L,
|
||
Milne RL,
|
||
Probst-Hensch N,
|
||
Reiner AP,
|
||
Ritz B,
|
||
Rotter JI,
|
||
Smith JA,
|
||
Taylor JA,
|
||
van Meurs JBJ,
|
||
Vineis P,
|
||
Waldenberger M,
|
||
Deary IJ,
|
||
Relton CL,
|
||
Horvath S,
|
||
Marioni RE</span><br />
|
||
<span class="medgenPMjournal">Genome Biol</span>
|
||
2021 Jun 29;22(1):194.
|
||
doi: 10.1186/s13059-021-02398-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34187551" target="_blank">34187551</a><a href="/pmc/articles/PMC8243879" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33432099">Role of PAI-1 in hepatic steatosis and dyslipidemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Levine JA,
|
||
Oleaga C,
|
||
Eren M,
|
||
Amaral AP,
|
||
Shang M,
|
||
Lux E,
|
||
Khan SS,
|
||
Shah SJ,
|
||
Omura Y,
|
||
Pamir N,
|
||
Hay J,
|
||
Barish G,
|
||
Miyata T,
|
||
Tavori H,
|
||
Fazio S,
|
||
Vaughan DE</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2021 Jan 11;11(1):430.
|
||
doi: 10.1038/s41598-020-79948-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33432099" target="_blank">33432099</a><a href="/pmc/articles/PMC7801442" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (152)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
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|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
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||
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|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4016325%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C4016325%5bDISCUI%5d&filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C4016325%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (3)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C4016325%5bDISCUI%5d" target="_blank">See all (4)</a></total></li>
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</ul></div>
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</div>
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||
<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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</div>
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(transcription%20level%20of%20plasminogen%20activator%20inhibitor%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201" target="_blank">MedlinePlus</a></li></ul></div>
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|
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|
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<div class="portlet brieflink">
|
||
<div class="portlet_head">
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<h3>Reviews</h3>
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<ul>
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<li>
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<a href="/pubmed/28771291" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
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<li>
|
||
<a href="/pubmed/clinical?term=Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
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||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Transcription%20level%20of%20plasminogen%20activator%20inhibitor%201%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
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|
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</div>
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|
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<!-- MedGen supplemental column ends here -->
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<div class="portlet brieflink">
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||
<div class="portlet_head">
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<div class="portlet_title">
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<h3>Related information</h3>
|
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</div>
|
||
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</div>
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<div class="portlet_content DiscoveryDbLinks">
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<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=864762" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C4016325[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C4016325[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=864762" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=864762" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
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</li>
|
||
<li class="brieflinkpopper">
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<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
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Bethesda, MD 20894</a></p>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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