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<meta name="keywords" content="C3553084, bilateral cleft palate, bilateral palatoschisis, cleft palate, bilateral, finding, right and left cleft palate, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Nonmidline cleft palate on the left and right sides." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=765998
|
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ConceptID=C3553084
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Bilateral cleft palate</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>765998</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C3553084</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Cleft palate, bilateral</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100337">HP:0100337</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Nonmidline cleft palate on the left and right sides. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Bilateral cleft palate</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867442" ref="tree=MeSH" title="MedGen record for Abnormality of head or neck">Abnormality of head or neck</a></span><ul><li><span class="TLline"><a href="/medgen/867438" ref="tree=MeSH" title="MedGen record for Abnormality of the head">Abnormality of the head</a></span><ul><li><span class="TLline"><a href="/medgen/1853793" ref="tree=MeSH" title="MedGen record for Craniofacial cleft">Craniofacial cleft</a></span><ul><li><span class="TLline"><a href="/medgen/472000" ref="tree=MeSH" title="MedGen record for Orofacial cleft">Orofacial cleft</a></span><ul><li><span class="TLline"><a href="/medgen/756015" ref="tree=MeSH" title="MedGen record for Cleft palate">Cleft palate</a></span><ul><li><span class="TLline"><a href="/medgen/867753" ref="tree=MeSH" title="MedGen record for Non-midline cleft palate">Non-midline cleft palate</a></span><ul><li><span class="matched_ds">Bilateral cleft palate</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
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||
<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_208652"><div><strong>Cholestasis-pigmentary retinopathy-cleft palate syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>208652</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0795969</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">MED12-related disorders include the phenotypes of FG syndrome type 1 (FGS1), Lujan syndrome (LS), X-linked Ohdo syndrome (XLOS), Hardikar syndrome (HS), and nonspecific intellectual disability (NSID). FGS1 and LS share the clinical findings of cognitive impairment, hypotonia, and abnormalities of the corpus callosum. FGS1 is further characterized by absolute or relative macrocephaly, tall forehead, downslanted palpebral fissures, small and simple ears, constipation and/or anal anomalies, broad thumbs and halluces, and characteristic behavior. LS is further characterized by large head, tall thin body habitus, long thin face, prominent nasal bridge, high narrow palate, and short philtrum. Carrier females in families with FGS1 and LS are typically unaffected. XLOS is characterized by intellectual disability, blepharophimosis, and facial coarsening. HS has been described in females with cleft lip and/or cleft palate, biliary and liver anomalies, intestinal malrotation, pigmentary retinopathy, and coarctation of the aorta. Developmental and cognitive concerns have not been reported in females with HS. Pathogenic variants in MED12 have been reported in an increasing number of males and females with NSID, with affected individuals often having clinical features identified in other MED12-related disorders.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/208652">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_208678"><div><strong>Bohring-Opitz syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>208678</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0796232</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bohring-Opitz syndrome (BOS) is characterized by distinctive facial features and posture, growth failure, variable but usually severe intellectual disability, and variable anomalies. The facial features may include microcephaly or trigonocephaly / prominent (but not fused) metopic ridge, hypotonic facies with full cheeks, synophrys, glabellar and eyelid nevus flammeus (simplex), prominent globes, widely set eyes, palate anomalies, and micrognathia. The BOS posture, which is most striking in early childhood and often becomes less apparent with age, is characterized by flexion at the elbows with ulnar deviation and flexion of the wrists and metacarpophalangeal joints. Feeding difficulties in early childhood, including cyclic vomiting, have a significant impact on overall health; feeding tends to improve with age. Seizures are common and typically responsive to standard epileptic medications. Minor cardiac anomalies and transient bradycardia and apnea may be present. Affected individuals may experience recurrent infections, which also tend to improve with age. Isolated case reports suggest that individuals with BOS are at greater risk for Wilms tumor than the general population, but large-scale epidemiologic studies have not been conducted.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/208678">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_321957"><div><strong>Amelia cleft lip palate hydrocephalus iris coloboma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>321957</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832434</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Brachial amelia, cleft lip, and holoprosencephaly (ACLH) is a severe multiple congenital anomaly disorder characterized by brachial amelia, cleft lip, and forebrain defects consistent with holoprosencephaly. Although the disorder is rarely reported, the features are consistent enough to constitute a distinct entity (summary by Kariminejad et al., 2009).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/321957">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_322166"><div><strong>Anophthalmia plus syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322166</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833339</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A very rare multiple congenital anomaly syndrome with characteristics of anophthalmia or severe microphthalmia, cleft lip/palate, facial cleft and sacral neural tube defects, along with various additional anomalies including congenital glaucoma, iris coloboma, primary hyperplastic vitreous, hypertelorism, low-set ears, clinodactyly, choanal atresia/stenosis, dysgenesis of sacrum, tethering of spinal cord, syringomyelia, hypoplasia of corpus callosum, cerebral ventriculomegaly and endocrine abnormalities. An autosomal recessive inheritance has been suggested.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/322166">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_322517"><div><strong>Holoprosencephaly 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322517</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1834877</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare disorder characterized by the partial separation of the cerebral hemispheres. It is associated with mutations in the SIX3 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/322517">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_324369"><div><strong>Holoprosencephaly 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>324369</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835819</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Holoprosencephaly-9 refers to a disorder characterized by a wide phenotypic spectrum of brain developmental defects, with or without overt forebrain cleavage abnormalities. It usually includes midline craniofacial anomalies involving the first branchial arch and/or orbits, pituitary hypoplasia with panhypopituitarism, and postaxial polydactyly. The disorder shows incomplete penetrance and variable expressivity (summary by Roessler et al., 2003 and Bertolacini et al., 2012). For general phenotypic information and a discussion of genetic heterogeneity of holoprosencephaly, see HPE1 (236100).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/324369">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_372134"><div><strong>Holoprosencephaly 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>372134</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835820</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Holoprosencephaly (HPE) is the most commonly occurring congenital structural forebrain anomaly in humans. HPE is associated with mental retardation and craniofacial malformations. Considerable heterogeneity in the genetic causes of HPE has been demonstrated (Ming et al., 2002). For general phenotypic information and a discussion of genetic heterogeneity of holoprosencephaly, see HPE1 (236100).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/372134">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_501218"><div><strong>17q11.2 microduplication syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>501218</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3495679</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Syndrome that has characteristics of dysmorphic features and intellectual deficit. It has been described in seven patients within one family. 17q11.2 microduplication encompasses the NF1 region. The underlying mechanism may be non-allelic homologous recombination. The study of pedigree suggests that this microduplication segregates within the family for at least two generations. Two patients displayed a normal clinical presentation, suggesting an autosomal dominant pattern of inheritance with incomplete penetrance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/501218">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766956"><div><strong>Diamond-Blackfan anemia 11</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766956</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554042</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Diamond-Blackfan anemia (DBA) is characterized by a profound normochromic and usually macrocytic anemia with normal leukocytes and platelets, congenital malformations in up to 50%, and growth deficiency in 30% of affected individuals. The hematologic complications occur in 90% of affected individuals during the first year of life. The phenotypic spectrum ranges from a mild form (e.g., mild anemia or no anemia with only subtle erythroid abnormalities, physical malformations without anemia) to a severe form of fetal anemia resulting in nonimmune hydrops fetalis. DBA is associated with an increased risk for acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), and solid tumors including osteogenic sarcoma.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766956">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_909661"><div><strong>Orofacial cleft 15</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>909661</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225209</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any cleft lip/palate in which the cause of the disease is a mutation in the DLX4 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/909661">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1714169"><div><strong>Neurodevelopmental disorder with relative macrocephaly and with or without cardiac or endocrine anomalies</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1714169</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5394221</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Nabais Sa-de Vries syndrome type 2 (NSDVS2) is characterized by global developmental delay apparent from birth and distinctive dysmorphic facial features. Most patients have additional anomalies, including congenital heart defects, sleep disturbances, hypotonia, and variable endocrine abnormalities, such as hypothyroidism (summary by Nabais Sa et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1714169">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1778443"><div><strong>Bartsocas-Papas syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1778443</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543445</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bartsocas-Papas syndrome-2 (BPS2) is a severe form of popliteal pterygium disorder characterized by cutaneous webbing across one or more joints, cleft lip and/or palate, syndactyly, and genital malformations (summary by Leslie et al., 2015).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1778443">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_501218" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">17q11.2 microduplication syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_321957" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Amelia cleft lip palate hydrocephalus iris coloboma</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322166" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anophthalmia plus syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1778443" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bartsocas-Papas syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_208678" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bohring-Opitz syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (12)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_208652" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cholestasis-pigmentary retinopathy-cleft palate syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766956" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diamond-Blackfan anemia 11</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322517" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Holoprosencephaly 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_372134" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Holoprosencephaly 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_324369" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Holoprosencephaly 9</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1714169" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with relative macrocephaly and with or without cardiac or endocrine anomalies</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_909661" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Orofacial cleft 15</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/23673163">Modified superior pharyngeal flap for the treatment of velopharyngeal insufficiency in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rogers DJ,
|
||
Ashland JE,
|
||
Rozeboom MJ,
|
||
Hartnick CJ</span><br />
|
||
<span class="medgenPMjournal">Int J Pediatr Otorhinolaryngol</span>
|
||
2013 Jul;77(7):1083-7.
|
||
Epub 2013 May 11
|
||
doi: 10.1016/j.ijporl.2013.03.035.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23673163" target="_blank">23673163</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20418035">Fetal cleft lip with and without cleft palate: comparison between MR imaging and US for prenatal diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang G,
|
||
Shan R,
|
||
Zhao L,
|
||
Zhu X,
|
||
Zhang X</span><br />
|
||
<span class="medgenPMjournal">Eur J Radiol</span>
|
||
2011 Sep;79(3):437-42.
|
||
Epub 2010 Apr 24
|
||
doi: 10.1016/j.ejrad.2010.03.026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20418035" target="_blank">20418035</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12697981">Outcome of treatment regarding articulation, resonance and voice in Flemish adults with unilateral and bilateral cleft palate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Van Lierde KM,
|
||
De Bodt M,
|
||
Baetens I,
|
||
Schrauwen V,
|
||
Van Cauwenberge P</span><br />
|
||
<span class="medgenPMjournal">Folia Phoniatr Logop</span>
|
||
2003 Mar-Apr;55(2):80-90.
|
||
doi: 10.1159/000070090.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12697981" target="_blank">12697981</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22bilateral%20cleft%20palate%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33136871">Cleft Palate Repair: A Study Between Two Surgical Procedures.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Astrada S,
|
||
Bennun RD</span><br />
|
||
<span class="medgenPMjournal">J Craniofac Surg</span>
|
||
2020 Nov/Dec;31(8):2280-2284.
|
||
doi: 10.1097/SCS.0000000000006814.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33136871" target="_blank">33136871</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31584550">Veau III and Veau IV Cleft Palate: Do Peri-Operative Complications Differ?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chouairi F,
|
||
Mets EJ,
|
||
Gabrick KS,
|
||
Alperovich M</span><br />
|
||
<span class="medgenPMjournal">J Craniofac Surg</span>
|
||
2019 Nov-Dec;30(8):2372-2374.
|
||
doi: 10.1097/SCS.0000000000005918.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31584550" target="_blank">31584550</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23189986">A novel intubation technique in bilateral cleft palate pediatric patients: hard gum shield-aided intubation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mahmoud AA,
|
||
Fouad AZ,
|
||
Mansour MA,
|
||
Kamal AM</span><br />
|
||
<span class="medgenPMjournal">Paediatr Anaesth</span>
|
||
2013 Apr;23(4):349-54.
|
||
Epub 2012 Nov 28
|
||
doi: 10.1111/pan.12080.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23189986" target="_blank">23189986</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20418035">Fetal cleft lip with and without cleft palate: comparison between MR imaging and US for prenatal diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang G,
|
||
Shan R,
|
||
Zhao L,
|
||
Zhu X,
|
||
Zhang X</span><br />
|
||
<span class="medgenPMjournal">Eur J Radiol</span>
|
||
2011 Sep;79(3):437-42.
|
||
Epub 2010 Apr 24
|
||
doi: 10.1016/j.ejrad.2010.03.026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20418035" target="_blank">20418035</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12697981">Outcome of treatment regarding articulation, resonance and voice in Flemish adults with unilateral and bilateral cleft palate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Van Lierde KM,
|
||
De Bodt M,
|
||
Baetens I,
|
||
Schrauwen V,
|
||
Van Cauwenberge P</span><br />
|
||
<span class="medgenPMjournal">Folia Phoniatr Logop</span>
|
||
2003 Mar-Apr;55(2):80-90.
|
||
doi: 10.1159/000070090.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12697981" target="_blank">12697981</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bilateral%20cleft%20palate%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26090787">Two-Dimensional Identification of Fetal Tooth Germs.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Seabra M,
|
||
Vaz P,
|
||
Valente F,
|
||
Braga A,
|
||
Felino A</span><br />
|
||
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
|
||
2017 Mar;54(2):166-169.
|
||
Epub 2015 Jun 19
|
||
doi: 10.1597/14-128.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26090787" target="_blank">26090787</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20418035">Fetal cleft lip with and without cleft palate: comparison between MR imaging and US for prenatal diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang G,
|
||
Shan R,
|
||
Zhao L,
|
||
Zhu X,
|
||
Zhang X</span><br />
|
||
<span class="medgenPMjournal">Eur J Radiol</span>
|
||
2011 Sep;79(3):437-42.
|
||
Epub 2010 Apr 24
|
||
doi: 10.1016/j.ejrad.2010.03.026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20418035" target="_blank">20418035</a></div>
|
||
|
||
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||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bilateral%20cleft%20palate%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div><h3 class="subhead">Therapy</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/33136871">Cleft Palate Repair: A Study Between Two Surgical Procedures.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Astrada S,
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<span class="bold">PMID: </span><a href="/pubmed/33136871" target="_blank">33136871</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/23189986">A novel intubation technique in bilateral cleft palate pediatric patients: hard gum shield-aided intubation.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Mahmoud AA,
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Fouad AZ,
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Mansour MA,
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Kamal AM</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/23189986" target="_blank">23189986</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/12943438">Cephalometric assessment of the posterior airway space in patients with cleft palate after palatoplasty.</a></div>
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Thissen U,
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Otten JE,
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||
<div class="nl"><a target="_blank" href="/pubmed/7552875">Cephalometric profile evaluations in patients with cleft lip and palate.</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/8418875">Speech in unilateral and bilateral cleft palate patients from Stockholm.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karling J,
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Larson O,
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Leanderson R,
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||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bilateral%20cleft%20palate%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33136871">Cleft Palate Repair: A Study Between Two Surgical Procedures.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Astrada S,
|
||
Bennun RD</span><br />
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<span class="medgenPMjournal">J Craniofac Surg</span>
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2020 Nov/Dec;31(8):2280-2284.
|
||
doi: 10.1097/SCS.0000000000006814.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33136871" target="_blank">33136871</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31584550">Veau III and Veau IV Cleft Palate: Do Peri-Operative Complications Differ?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chouairi F,
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Mets EJ,
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Gabrick KS,
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Alperovich M</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/31584550" target="_blank">31584550</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/30100383">Midfacial growth and dental arch relationships in bilateral cleft palate following secondary alveolar bone grafting and orthodontic intervention: Factors predicting a Le Fort I osteotomy at age 18.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bittermann GKP,
|
||
de Ruiter AP,
|
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Bittermann AJ,
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Mink van de Molen AB,
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van Es RJ,
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Koole R,
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Rosenberg AJ</span><br />
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Epub 2018 Jul 26
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||
<span class="bold">PMID: </span><a href="/pubmed/30100383" target="_blank">30100383</a></div>
|
||
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||
<div class="nl"><a target="_blank" href="/pubmed/26080153">Maxillary Distraction Osteogenesis Using a Rigid External Distractor: Which Clinical Factors Are Related With Relapse?</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim J,
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Uhm KI,
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Shin D,
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Lee J,
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Choi H</span><br />
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<span class="medgenPMjournal">J Craniofac Surg</span>
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2015 Jun;26(4):1178-81.
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doi: 10.1097/SCS.0000000000001568.
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<span class="bold">PMID: </span><a href="/pubmed/26080153" target="_blank">26080153</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/16405371">Use of vomer flap in palatoplasty: revisited.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Agrawal K,
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Panda KN</span><br />
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<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
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doi: 10.1597/04-034.1.
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<span class="bold">PMID: </span><a href="/pubmed/16405371" target="_blank">16405371</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bilateral%20cleft%20palate%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30100383">Midfacial growth and dental arch relationships in bilateral cleft palate following secondary alveolar bone grafting and orthodontic intervention: Factors predicting a Le Fort I osteotomy at age 18.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bittermann GKP,
|
||
de Ruiter AP,
|
||
Bittermann AJ,
|
||
Mink van de Molen AB,
|
||
van Es RJ,
|
||
Koole R,
|
||
Rosenberg AJ</span><br />
|
||
<span class="medgenPMjournal">J Craniomaxillofac Surg</span>
|
||
2018 Oct;46(10):1764-1771.
|
||
Epub 2018 Jul 26
|
||
doi: 10.1016/j.jcms.2018.07.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30100383" target="_blank">30100383</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26090787">Two-Dimensional Identification of Fetal Tooth Germs.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Seabra M,
|
||
Vaz P,
|
||
Valente F,
|
||
Braga A,
|
||
Felino A</span><br />
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||
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
|
||
2017 Mar;54(2):166-169.
|
||
Epub 2015 Jun 19
|
||
doi: 10.1597/14-128.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26090787" target="_blank">26090787</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23189986">A novel intubation technique in bilateral cleft palate pediatric patients: hard gum shield-aided intubation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mahmoud AA,
|
||
Fouad AZ,
|
||
Mansour MA,
|
||
Kamal AM</span><br />
|
||
<span class="medgenPMjournal">Paediatr Anaesth</span>
|
||
2013 Apr;23(4):349-54.
|
||
Epub 2012 Nov 28
|
||
doi: 10.1111/pan.12080.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23189986" target="_blank">23189986</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12697981">Outcome of treatment regarding articulation, resonance and voice in Flemish adults with unilateral and bilateral cleft palate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Van Lierde KM,
|
||
De Bodt M,
|
||
Baetens I,
|
||
Schrauwen V,
|
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Van Cauwenberge P</span><br />
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2003 Mar-Apr;55(2):80-90.
|
||
doi: 10.1159/000070090.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12697981" target="_blank">12697981</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8418875">Speech in unilateral and bilateral cleft palate patients from Stockholm.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karling J,
|
||
Larson O,
|
||
Leanderson R,
|
||
Henningsson G</span><br />
|
||
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
|
||
1993 Jan;30(1):73-7.
|
||
doi: 10.1597/1545-1569_1993_030_0073_siuabc_2.3.co_2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8418875" target="_blank">8418875</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bilateral%20cleft%20palate%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
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|
||
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||
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|
||
|
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</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
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<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Bilateral%20cleft%20palate" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22bilateral%20cleft%20palate%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Bilateral%20cleft%20palate" target="_blank">MedlinePlus</a></li></ul></div>
|
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|
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|
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<div class="portlet_head">
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<h3>Reviews</h3>
|
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</div>
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<ul>
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<li>
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<a href="/pubmed/clinical?term=Bilateral%20cleft%20palate" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
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</li>
|
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<li>
|
||
<a href="/pubmed?term=Bilateral%20cleft%20palate%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
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</li>
|
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</ul>
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<h3>Related information</h3>
|
||
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