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<meta name="keywords" content="C3539120, elac2, elac2 familial prostate cancer, familial prostate cancer caused by mutation in elac2, hpc2, neoplastic process, prostate cancer, hereditary, 2, prostate cancer, hereditary, 2, susceptibility to, prostate cancer, hereditary, type 2, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Prostate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal, multiply without control or order, and form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm.\n\nEarly prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical exam called a digital rectal exam (DRE). As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.\n\nThe severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.\n\nSome cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. \n\nA small percentage of prostate cancers are hereditary and occur in families. These hereditary cancers are associated with inherited gene variants. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=761328
ConceptID=C3539120
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Prostate cancer, hereditary, 2<span class="h1sub">(HPC2)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>761328</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C3539120</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>HPC2</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="ELAC2 - ID: 60528 - NCBI Gene" href="/gene/60528" class="medgenPMinfo">ELAC2</a> (17p12)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0013872" target="_blank">MONDO:0013872</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/614731" target="_blank">614731</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Prostate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal, multiply without control or order, and form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm.<br /><br />Early prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical exam called a digital rectal exam (DRE). As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.<br /><br />The severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.<br /><br />Some cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. <br /><br />A small percentage of prostate cancers are hereditary and occur in families. These hereditary cancers are associated with inherited gene variants. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
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<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/39052257">BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients: A Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng HH,
Shevach JW,
Castro E,
Couch FJ,
Domchek SM,
Eeles RA,
Giri VN,
Hall MJ,
King MC,
Lin DW,
Loeb S,
Morgan TM,
Offit K,
Pritchard CC,
Schaeffer EM,
Szymaniak BM,
Vassy JL,
Katona BW,
Maxwell KN</span><br />
<span class="medgenPMjournal">JAMA Oncol</span>
2024 Sep 1;10(9):1272-1281.
doi: 10.1001/jamaoncol.2024.2185.
<span class="bold">PMID: </span><a href="/pubmed/39052257" target="_blank">39052257</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37856201">NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Daly MB,
Pal T,
Maxwell KN,
Churpek J,
Kohlmann W,
AlHilli Z,
Arun B,
Buys SS,
Cheng H,
Domchek SM,
Friedman S,
Giri V,
Goggins M,
Hagemann A,
Hendrix A,
Hutton ML,
Karlan BY,
Kassem N,
Khan S,
Khoury K,
Kurian AW,
Laronga C,
Mak JS,
Mansour J,
McDonnell K,
Menendez CS,
Merajver SD,
Norquist BS,
Offit K,
Rash D,
Reiser G,
Senter-Jamieson L,
Shannon KM,
Visvanathan K,
Welborn J,
Wick MJ,
Wood M,
Yurgelun MB,
Dwyer MA,
Darlow SD</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2023 Oct;21(10):1000-1010.
doi: 10.6004/jnccn.2023.0051.
<span class="bold">PMID: </span><a href="/pubmed/37856201" target="_blank">37856201</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37490054">Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hanson H,
Astiazaran-Symonds E,
Amendola LM,
Balmaña J,
Foulkes WD,
James P,
Klugman S,
Ngeow J,
Schmutzler R,
Voian N,
Wick MJ,
Pal T,
Tischkowitz M,
Stewart DR;
ACMG Professional Practices and Guidelines Committee. Electronic address: documents@acmg.net</span><br />
<span class="medgenPMjournal">Genet Med</span>
2023 Oct;25(10):100870.
Epub 2023 Jul 25
doi: 10.1016/j.gim.2023.100870.
<span class="bold">PMID: </span><a href="/pubmed/37490054" target="_blank">37490054</a><a href="/pmc/articles/PMC10623578" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(prostate%20cancer%2C%20hereditary%2C%202)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (46)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37856201">NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Daly MB,
Pal T,
Maxwell KN,
Churpek J,
Kohlmann W,
AlHilli Z,
Arun B,
Buys SS,
Cheng H,
Domchek SM,
Friedman S,
Giri V,
Goggins M,
Hagemann A,
Hendrix A,
Hutton ML,
Karlan BY,
Kassem N,
Khan S,
Khoury K,
Kurian AW,
Laronga C,
Mak JS,
Mansour J,
McDonnell K,
Menendez CS,
Merajver SD,
Norquist BS,
Offit K,
Rash D,
Reiser G,
Senter-Jamieson L,
Shannon KM,
Visvanathan K,
Welborn J,
Wick MJ,
Wood M,
Yurgelun MB,
Dwyer MA,
Darlow SD</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2023 Oct;21(10):1000-1010.
doi: 10.6004/jnccn.2023.0051.
<span class="bold">PMID: </span><a href="/pubmed/37856201" target="_blank">37856201</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37490054">Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hanson H,
Astiazaran-Symonds E,
Amendola LM,
Balmaña J,
Foulkes WD,
James P,
Klugman S,
Ngeow J,
Schmutzler R,
Voian N,
Wick MJ,
Pal T,
Tischkowitz M,
Stewart DR;
ACMG Professional Practices and Guidelines Committee. Electronic address: documents@acmg.net</span><br />
<span class="medgenPMjournal">Genet Med</span>
2023 Oct;25(10):100870.
Epub 2023 Jul 25
doi: 10.1016/j.gim.2023.100870.
<span class="bold">PMID: </span><a href="/pubmed/37490054" target="_blank">37490054</a><a href="/pmc/articles/PMC10623578" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35077220">Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li S,
Silvestri V,
Leslie G,
Rebbeck TR,
Neuhausen SL,
Hopper JL,
Nielsen HR,
Lee A,
Yang X,
McGuffog L,
Parsons MT,
Andrulis IL,
Arnold N,
Belotti M,
Borg Å,
Buecher B,
Buys SS,
Caputo SM,
Chung WK,
Colas C,
Colonna SV,
Cook J,
Daly MB,
de la Hoya M,
de Pauw A,
Delhomelle H,
Eason J,
Engel C,
Evans DG,
Faust U,
Fehm TN,
Fostira F,
Fountzilas G,
Frone M,
Garcia-Barberan V,
Garre P,
Gauthier-Villars M,
Gehrig A,
Glendon G,
Goldgar DE,
Golmard L,
Greene MH,
Hahnen E,
Hamann U,
Hanson H,
Hassan T,
Hentschel J,
Horvath J,
Izatt L,
Janavicius R,
Jiao Y,
John EM,
Karlan BY,
Kim SW,
Konstantopoulou I,
Kwong A,
Laugé A,
Lee JW,
Lesueur F,
Mebirouk N,
Meindl A,
Mouret-Fourme E,
Musgrave H,
Ngeow Yuen Yie J,
Niederacher D,
Park SK,
Pedersen IS,
Ramser J,
Ramus SJ,
Rantala J,
Rashid MU,
Reichl F,
Ritter J,
Rump A,
Santamariña M,
Saule C,
Schmidt G,
Schmutzler RK,
Senter L,
Shariff S,
Singer CF,
Southey MC,
Stoppa-Lyonnet D,
Sutter C,
Tan Y,
Teo SH,
Terry MB,
Thomassen M,
Tischkowitz M,
Toland AE,
Torres D,
Vega A,
Wagner SA,
Wang-Gohrke S,
Wappenschmidt B,
Weber BHF,
Yannoukakos D,
Spurdle AB,
Easton DF,
Chenevix-Trench G,
Ottini L,
Antoniou AC</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2022 May 10;40(14):1529-1541.
Epub 2022 Jan 25
doi: 10.1200/JCO.21.02112.
<span class="bold">PMID: </span><a href="/pubmed/35077220" target="_blank">35077220</a><a href="/pmc/articles/PMC9084432" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34577828">BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lee YC,
Lee YL,
Li CY</span><br />
<span class="medgenPMjournal">Medicina (Kaunas)</span>
2021 Aug 30;57(9)
doi: 10.3390/medicina57090905.
<span class="bold">PMID: </span><a href="/pubmed/34577828" target="_blank">34577828</a><a href="/pmc/articles/PMC8464901" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33916521">Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vietri MT,
D'Elia G,
Caliendo G,
Resse M,
Casamassimi A,
Passariello L,
Albanese L,
Cioffi M,
Molinari AM</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Apr 4;22(7)
doi: 10.3390/ijms22073753.
<span class="bold">PMID: </span><a href="/pubmed/33916521" target="_blank">33916521</a><a href="/pmc/articles/PMC8038462" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2C%20hereditary%2C%202%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (426)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37856201">NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Daly MB,
Pal T,
Maxwell KN,
Churpek J,
Kohlmann W,
AlHilli Z,
Arun B,
Buys SS,
Cheng H,
Domchek SM,
Friedman S,
Giri V,
Goggins M,
Hagemann A,
Hendrix A,
Hutton ML,
Karlan BY,
Kassem N,
Khan S,
Khoury K,
Kurian AW,
Laronga C,
Mak JS,
Mansour J,
McDonnell K,
Menendez CS,
Merajver SD,
Norquist BS,
Offit K,
Rash D,
Reiser G,
Senter-Jamieson L,
Shannon KM,
Visvanathan K,
Welborn J,
Wick MJ,
Wood M,
Yurgelun MB,
Dwyer MA,
Darlow SD</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2023 Oct;21(10):1000-1010.
doi: 10.6004/jnccn.2023.0051.
<span class="bold">PMID: </span><a href="/pubmed/37856201" target="_blank">37856201</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37490054">Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hanson H,
Astiazaran-Symonds E,
Amendola LM,
Balmaña J,
Foulkes WD,
James P,
Klugman S,
Ngeow J,
Schmutzler R,
Voian N,
Wick MJ,
Pal T,
Tischkowitz M,
Stewart DR;
ACMG Professional Practices and Guidelines Committee. Electronic address: documents@acmg.net</span><br />
<span class="medgenPMjournal">Genet Med</span>
2023 Oct;25(10):100870.
Epub 2023 Jul 25
doi: 10.1016/j.gim.2023.100870.
<span class="bold">PMID: </span><a href="/pubmed/37490054" target="_blank">37490054</a><a href="/pmc/articles/PMC10623578" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37455374">Hereditary breast and ovarian cancer: from genes to molecular targeted therapies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ponti G,
De Angelis C,
Ponti R,
Pongetti L,
Losi L,
Sticchi A,
Tomasi A,
Ozben T</span><br />
<span class="medgenPMjournal">Crit Rev Clin Lab Sci</span>
2023 Dec;60(8):640-650.
Epub 2023 Jul 16
doi: 10.1080/10408363.2023.2234488.
<span class="bold">PMID: </span><a href="/pubmed/37455374" target="_blank">37455374</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35008774">Homologous Recombination Deficiencies and Hereditary Tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yamamoto H,
Hirasawa A</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Dec 29;23(1)
doi: 10.3390/ijms23010348.
<span class="bold">PMID: </span><a href="/pubmed/35008774" target="_blank">35008774</a><a href="/pmc/articles/PMC8745585" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33916521">Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vietri MT,
D'Elia G,
Caliendo G,
Resse M,
Casamassimi A,
Passariello L,
Albanese L,
Cioffi M,
Molinari AM</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Apr 4;22(7)
doi: 10.3390/ijms22073753.
<span class="bold">PMID: </span><a href="/pubmed/33916521" target="_blank">33916521</a><a href="/pmc/articles/PMC8038462" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2C%20hereditary%2C%202%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (254)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/39187844">The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Herencia-Ropero A,
Llop-Guevara A,
Staniszewska AD,
Domènech-Vivó J,
García-Galea E,
Moles-Fernández A,
Pedretti F,
Domènech H,
Rodríguez O,
Guzmán M,
Arenas EJ,
Verdaguer H,
Calero-Nieto FJ,
Talbot S,
Tobalina L,
Leo E,
Lau A,
Nuciforo P,
Dienstmann R,
Macarulla T,
Arribas J,
Díez O,
Gutiérrez-Enríquez S,
Forment JV,
O'Connor MJ,
Albertella M,
Balmaña J,
Serra V</span><br />
<span class="medgenPMjournal">Genome Med</span>
2024 Aug 26;16(1):107.
doi: 10.1186/s13073-024-01370-z.
<span class="bold">PMID: </span><a href="/pubmed/39187844" target="_blank">39187844</a><a href="/pmc/articles/PMC11348616" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/39052257">BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients: A Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng HH,
Shevach JW,
Castro E,
Couch FJ,
Domchek SM,
Eeles RA,
Giri VN,
Hall MJ,
King MC,
Lin DW,
Loeb S,
Morgan TM,
Offit K,
Pritchard CC,
Schaeffer EM,
Szymaniak BM,
Vassy JL,
Katona BW,
Maxwell KN</span><br />
<span class="medgenPMjournal">JAMA Oncol</span>
2024 Sep 1;10(9):1272-1281.
doi: 10.1001/jamaoncol.2024.2185.
<span class="bold">PMID: </span><a href="/pubmed/39052257" target="_blank">39052257</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37021836">Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Militaru FC,
Militaru V,
Crisan N,
Bocsan IC,
Udrea AA,
Catana A,
Kutasi E,
Militaru MS</span><br />
<span class="medgenPMjournal">Biomol Biomed</span>
2023 Sep 4;23(5):760-771.
doi: 10.17305/bb.2023.8782.
<span class="bold">PMID: </span><a href="/pubmed/37021836" target="_blank">37021836</a><a href="/pmc/articles/PMC10494850" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35425960">Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pellegrino B,
Herencia-Ropero A,
Llop-Guevara A,
Pedretti F,
Moles-Fernández A,
Viaplana C,
Villacampa G,
Guzmán M,
Rodríguez O,
Grueso J,
Jiménez J,
Arenas EJ,
Degasperi A,
Dias JML,
Forment JV,
O'Connor MJ,
Déas O,
Cairo S,
Zhou Y,
Musolino A,
Caldas C,
Nik-Zainal S,
Clarke RB,
Nuciforo P,
Díez O,
Serres-Créixams X,
Peg V,
Espinosa-Bravo M,
Macarulla T,
Oaknin A,
Mateo J,
Arribas J,
Dienstmann R,
Bellet M,
Oliveira M,
Saura C,
Gutiérrez-Enríquez S,
Balmaña J,
Serra V</span><br />
<span class="medgenPMjournal">Cancer Res</span>
2022 Apr 15;82(8):1646-1657.
doi: 10.1158/0008-5472.CAN-21-2409.
<span class="bold">PMID: </span><a href="/pubmed/35425960" target="_blank">35425960</a><a href="/pmc/articles/PMC7612637" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31783313">Hereditary prostate cancer - Primetime for genetic testing?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Heidegger I,
Tsaur I,
Borgmann H,
Surcel C,
Kretschmer A,
Mathieu R,
Visschere P,
Valerio M,
van den Bergh RCN,
Ost P,
Tilki D,
Gandaglia G,
Ploussard G;
EAU-YAU Prostate Cancer Working Party</span><br />
<span class="medgenPMjournal">Cancer Treat Rev</span>
2019 Dec;81:101927.
Epub 2019 Nov 11
doi: 10.1016/j.ctrv.2019.101927.
<span class="bold">PMID: </span><a href="/pubmed/31783313" target="_blank">31783313</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2C%20hereditary%2C%202%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (62)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37455374">Hereditary breast and ovarian cancer: from genes to molecular targeted therapies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ponti G,
De Angelis C,
Ponti R,
Pongetti L,
Losi L,
Sticchi A,
Tomasi A,
Ozben T</span><br />
<span class="medgenPMjournal">Crit Rev Clin Lab Sci</span>
2023 Dec;60(8):640-650.
Epub 2023 Jul 16
doi: 10.1080/10408363.2023.2234488.
<span class="bold">PMID: </span><a href="/pubmed/37455374" target="_blank">37455374</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33916521">Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vietri MT,
D'Elia G,
Caliendo G,
Resse M,
Casamassimi A,
Passariello L,
Albanese L,
Cioffi M,
Molinari AM</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Apr 4;22(7)
doi: 10.3390/ijms22073753.
<span class="bold">PMID: </span><a href="/pubmed/33916521" target="_blank">33916521</a><a href="/pmc/articles/PMC8038462" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31337882">Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dominguez-Valentin M,
Sampson JR,
Seppälä TT,
Ten Broeke SW,
Plazzer JP,
Nakken S,
Engel C,
Aretz S,
Jenkins MA,
Sunde L,
Bernstein I,
Capella G,
Balaguer F,
Thomas H,
Evans DG,
Burn J,
Greenblatt M,
Hovig E,
de Vos Tot Nederveen Cappel WH,
Sijmons RH,
Bertario L,
Tibiletti MG,
Cavestro GM,
Lindblom A,
Della Valle A,
Lopez-Köstner F,
Gluck N,
Katz LH,
Heinimann K,
Vaccaro CA,
Büttner R,
Görgens H,
Holinski-Feder E,
Morak M,
Holzapfel S,
Hüneburg R,
Knebel Doeberitz MV,
Loeffler M,
Rahner N,
Schackert HK,
Steinke-Lange V,
Schmiegel W,
Vangala D,
Pylvänäinen K,
Renkonen-Sinisalo L,
Hopper JL,
Win AK,
Haile RW,
Lindor NM,
Gallinger S,
Le Marchand L,
Newcomb PA,
Figueiredo JC,
Thibodeau SN,
Wadt K,
Therkildsen C,
Okkels H,
Ketabi Z,
Moreira L,
Sánchez A,
Serra-Burriel M,
Pineda M,
Navarro M,
Blanco I,
Green K,
Lalloo F,
Crosbie EJ,
Hill J,
Denton OG,
Frayling IM,
Rødland EA,
Vasen H,
Mints M,
Neffa F,
Esperon P,
Alvarez K,
Kariv R,
Rosner G,
Pinero TA,
Gonzalez ML,
Kalfayan P,
Tjandra D,
Winship IM,
Macrae F,
Möslein G,
Mecklin JP,
Nielsen M,
Møller P</span><br />
<span class="medgenPMjournal">Genet Med</span>
2020 Jan;22(1):15-25.
Epub 2019 Jul 24
doi: 10.1038/s41436-019-0596-9.
<span class="bold">PMID: </span><a href="/pubmed/31337882" target="_blank">31337882</a><a href="/pmc/articles/PMC7371626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30376427">Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Latham A,
Srinivasan P,
Kemel Y,
Shia J,
Bandlamudi C,
Mandelker D,
Middha S,
Hechtman J,
Zehir A,
Dubard-Gault M,
Tran C,
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Penson A,
DeLair D,
Yaeger R,
Vijai J,
Mukherjee S,
Galle J,
Dickson MA,
Janjigian Y,
O'Reilly EM,
Segal N,
Saltz LB,
Reidy-Lagunes D,
Varghese AM,
Bajorin D,
Carlo MI,
Cadoo K,
Walsh MF,
Weiser M,
Aguilar JG,
Klimstra DS,
Diaz LA Jr,
Baselga J,
Zhang L,
Ladanyi M,
Hyman DM,
Solit DB,
Robson ME,
Taylor BS,
Offit K,
Berger MF,
Stadler ZK</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2019 Feb 1;37(4):286-295.
Epub 2018 Oct 30
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<span class="bold">PMID: </span><a href="/pubmed/30376427" target="_blank">30376427</a><a href="/pmc/articles/PMC6553803" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29892016">Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schumacher FR,
Al Olama AA,
Berndt SI,
Benlloch S,
Ahmed M,
Saunders EJ,
Dadaev T,
Leongamornlert D,
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Cieza-Borrella C,
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Tangen CM,
Goodman PJ,
Thompson IM Jr,
Batra J,
Chambers S,
Moya L,
Clements J,
Horvath L,
Tilley W,
Risbridger GP,
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Kerns SL,
Ostrer H,
Lu YJ,
Zhang HW,
Feng N,
Mao X,
Guo X,
Wang G,
Sun Z,
Giles GG,
Southey MC,
MacInnis RJ,
FitzGerald LM,
Kibel AS,
Drake BF,
Vega A,
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Lin HY,
Stanford JL,
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Weischer M,
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Holleczek B,
Maier C,
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Schnoeller T,
Kim J,
Logothetis CJ,
John EM,
Teixeira MR,
Paulo P,
Cardoso M,
Neuhausen SL,
Steele L,
Ding YC,
De Ruyck K,
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Ost P,
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Teo SH,
Lin DW,
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Singhal S,
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Menegaux F,
Truong T,
Koudou YA,
Xu J,
Khaw KT,
Cannon-Albright L,
Pandha H,
Michael A,
Thibodeau SN,
McDonnell SK,
Schaid DJ,
Lindstrom S,
Turman C,
Ma J,
Hunter DJ,
Riboli E,
Siddiq A,
Canzian F,
Kolonel LN,
Le Marchand L,
Hoover RN,
Machiela MJ,
Cui Z,
Kraft P,
Amos CI,
Conti DV,
Easton DF,
Wiklund F,
Chanock SJ,
Henderson BE,
Kote-Jarai Z,
Haiman CA,
Eeles RA;
Profile Study;
Australian Prostate Cancer BioResource (APCB);
IMPACT Study;
Canary PASS Investigators;
Breast and Prostate Cancer Cohort Consortium (BPC3);
PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium;
Cancer of the Prostate in Sweden (CAPS);
Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS);
Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2018 Jul;50(7):928-936.
Epub 2018 Jun 11
doi: 10.1038/s41588-018-0142-8.
<span class="bold">PMID: </span><a href="/pubmed/29892016" target="_blank">29892016</a><a href="/pmc/articles/PMC6568012" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2C%20hereditary%2C%202%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (157)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/39052257">BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients: A Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng HH,
Shevach JW,
Castro E,
Couch FJ,
Domchek SM,
Eeles RA,
Giri VN,
Hall MJ,
King MC,
Lin DW,
Loeb S,
Morgan TM,
Offit K,
Pritchard CC,
Schaeffer EM,
Szymaniak BM,
Vassy JL,
Katona BW,
Maxwell KN</span><br />
<span class="medgenPMjournal">JAMA Oncol</span>
2024 Sep 1;10(9):1272-1281.
doi: 10.1001/jamaoncol.2024.2185.
<span class="bold">PMID: </span><a href="/pubmed/39052257" target="_blank">39052257</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37945903">Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang A,
Shen J,
Rodriguez AA,
Saunders EJ,
Chen F,
Janivara R,
Darst BF,
Sheng X,
Xu Y,
Chou AJ,
Benlloch S,
Dadaev T,
Brook MN,
Plym A,
Sahimi A,
Hoffman TJ,
Takahashi A,
Matsuda K,
Momozawa Y,
Fujita M,
Laisk T,
Figuerêdo J,
Muir K,
Ito S,
Liu X;
Biobank Japan Project,
Uchio Y,
Kubo M,
Kamatani Y,
Lophatananon A,
Wan P,
Andrews C,
Lori A,
Choudhury PP,
Schleutker J,
Tammela TLJ,
Sipeky C,
Auvinen A,
Giles GG,
Southey MC,
MacInnis RJ,
Cybulski C,
Wokolorczyk D,
Lubinski J,
Rentsch CT,
Cho K,
Mcmahon BH,
Neal DE,
Donovan JL,
Hamdy FC,
Martin RM,
Nordestgaard BG,
Nielsen SF,
Weischer M,
Bojesen SE,
Røder A,
Stroomberg HV,
Batra J,
Chambers S,
Horvath L,
Clements JA,
Tilly W,
Risbridger GP,
Gronberg H,
Aly M,
Szulkin R,
Eklund M,
Nordstrom T,
Pashayan N,
Dunning AM,
Ghoussaini M,
Travis RC,
Key TJ,
Riboli E,
Park JY,
Sellers TA,
Lin HY,
Albanes D,
Weinstein S,
Cook MB,
Mucci LA,
Giovannucci E,
Lindstrom S,
Kraft P,
Hunter DJ,
Penney KL,
Turman C,
Tangen CM,
Goodman PJ,
Thompson IM Jr,
Hamilton RJ,
Fleshner NE,
Finelli A,
Parent MÉ,
Stanford JL,
Ostrander EA,
Koutros S,
Beane Freeman LE,
Stampfer M,
Wolk A,
Håkansson N,
Andriole GL,
Hoover RN,
Machiela MJ,
Sørensen KD,
Borre M,
Blot WJ,
Zheng W,
Yeboah ED,
Mensah JE,
Lu YJ,
Zhang HW,
Feng N,
Mao X,
Wu Y,
Zhao SC,
Sun Z,
Thibodeau SN,
McDonnell SK,
Schaid DJ,
West CML,
Barnett G,
Maier C,
Schnoeller T,
Luedeke M,
Kibel AS,
Drake BF,
Cussenot O,
Cancel-Tassin G,
Menegaux F,
Truong T,
Koudou YA,
John EM,
Grindedal EM,
Maehle L,
Khaw KT,
Ingles SA,
Stern MC,
Vega A,
Gómez-Caamaño A,
Fachal L,
Rosenstein BS,
Kerns SL,
Ostrer H,
Teixeira MR,
Paulo P,
Brandão A,
Watya S,
Lubwama A,
Bensen JT,
Butler EN,
Mohler JL,
Taylor JA,
Kogevinas M,
Dierssen-Sotos T,
Castaño-Vinyals G,
Cannon-Albright L,
Teerlink CC,
Huff CD,
Pilie P,
Yu Y,
Bohlender RJ,
Gu J,
Strom SS,
Multigner L,
Blanchet P,
Brureau L,
Kaneva R,
Slavov C,
Mitev V,
Leach RJ,
Brenner H,
Chen X,
Holleczek B,
Schöttker B,
Klein EA,
Hsing AW,
Kittles RA,
Murphy AB,
Logothetis CJ,
Kim J,
Neuhausen SL,
Steele L,
Ding YC,
Isaacs WB,
Nemesure B,
Hennis AJM,
Carpten J,
Pandha H,
Michael A,
De Ruyck K,
De Meerleer G,
Ost P,
Xu J,
Razack A,
Lim J,
Teo SH,
Newcomb LF,
Lin DW,
Fowke JH,
Neslund-Dudas CM,
Rybicki BA,
Gamulin M,
Lessel D,
Kulis T,
Usmani N,
Abraham A,
Singhal S,
Parliament M,
Claessens F,
Joniau S,
Van den Broeck T,
Gago-Dominguez M,
Castelao JE,
Martinez ME,
Larkin S,
Townsend PA,
Aukim-Hastie C,
Bush WS,
Aldrich MC,
Crawford DC,
Srivastava S,
Cullen J,
Petrovics G,
Casey G,
Wang Y,
Tettey Y,
Lachance J,
Tang W,
Biritwum RB,
Adjei AA,
Tay E,
Truelove A,
Niwa S,
Yamoah K,
Govindasami K,
Chokkalingam AP,
Keaton JM,
Hellwege JN,
Clark PE,
Jalloh M,
Gueye SM,
Niang L,
Ogunbiyi O,
Shittu O,
Amodu O,
Adebiyi AO,
Aisuodionoe-Shadrach OI,
Ajibola HO,
Jamda MA,
Oluwole OP,
Nwegbu M,
Adusei B,
Mante S,
Darkwa-Abrahams A,
Diop H,
Gundell SM,
Roobol MJ,
Jenster G,
van Schaik RHN,
Hu JJ,
Sanderson M,
Kachuri L,
Varma R,
McKean-Cowdin R,
Torres M,
Preuss MH,
Loos RJF,
Zawistowski M,
Zöllner S,
Lu Z,
Van Den Eeden SK,
Easton DF,
Ambs S,
Edwards TL,
Mägi R,
Rebbeck TR,
Fritsche L,
Chanock SJ,
Berndt SI,
Wiklund F,
Nakagawa H,
Witte JS,
Gaziano JM,
Justice AC,
Mancuso N,
Terao C,
Eeles RA,
Kote-Jarai Z,
Madduri RK,
Conti DV,
Haiman CA</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2023 Dec;55(12):2065-2074.
Epub 2023 Nov 9
doi: 10.1038/s41588-023-01534-4.
<span class="bold">PMID: </span><a href="/pubmed/37945903" target="_blank">37945903</a><a href="/pmc/articles/PMC10841479" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37455374">Hereditary breast and ovarian cancer: from genes to molecular targeted therapies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ponti G,
De Angelis C,
Ponti R,
Pongetti L,
Losi L,
Sticchi A,
Tomasi A,
Ozben T</span><br />
<span class="medgenPMjournal">Crit Rev Clin Lab Sci</span>
2023 Dec;60(8):640-650.
Epub 2023 Jul 16
doi: 10.1080/10408363.2023.2234488.
<span class="bold">PMID: </span><a href="/pubmed/37455374" target="_blank">37455374</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33916521">Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vietri MT,
D'Elia G,
Caliendo G,
Resse M,
Casamassimi A,
Passariello L,
Albanese L,
Cioffi M,
Molinari AM</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Apr 4;22(7)
doi: 10.3390/ijms22073753.
<span class="bold">PMID: </span><a href="/pubmed/33916521" target="_blank">33916521</a><a href="/pmc/articles/PMC8038462" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29892016">Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schumacher FR,
Al Olama AA,
Berndt SI,
Benlloch S,
Ahmed M,
Saunders EJ,
Dadaev T,
Leongamornlert D,
Anokian E,
Cieza-Borrella C,
Goh C,
Brook MN,
Sheng X,
Fachal L,
Dennis J,
Tyrer J,
Muir K,
Lophatananon A,
Stevens VL,
Gapstur SM,
Carter BD,
Tangen CM,
Goodman PJ,
Thompson IM Jr,
Batra J,
Chambers S,
Moya L,
Clements J,
Horvath L,
Tilley W,
Risbridger GP,
Gronberg H,
Aly M,
Nordström T,
Pharoah P,
Pashayan N,
Schleutker J,
Tammela TLJ,
Sipeky C,
Auvinen A,
Albanes D,
Weinstein S,
Wolk A,
Håkansson N,
West CML,
Dunning AM,
Burnet N,
Mucci LA,
Giovannucci E,
Andriole GL,
Cussenot O,
Cancel-Tassin G,
Koutros S,
Beane Freeman LE,
Sorensen KD,
Orntoft TF,
Borre M,
Maehle L,
Grindedal EM,
Neal DE,
Donovan JL,
Hamdy FC,
Martin RM,
Travis RC,
Key TJ,
Hamilton RJ,
Fleshner NE,
Finelli A,
Ingles SA,
Stern MC,
Rosenstein BS,
Kerns SL,
Ostrer H,
Lu YJ,
Zhang HW,
Feng N,
Mao X,
Guo X,
Wang G,
Sun Z,
Giles GG,
Southey MC,
MacInnis RJ,
FitzGerald LM,
Kibel AS,
Drake BF,
Vega A,
Gómez-Caamaño A,
Szulkin R,
Eklund M,
Kogevinas M,
Llorca J,
Castaño-Vinyals G,
Penney KL,
Stampfer M,
Park JY,
Sellers TA,
Lin HY,
Stanford JL,
Cybulski C,
Wokolorczyk D,
Lubinski J,
Ostrander EA,
Geybels MS,
Nordestgaard BG,
Nielsen SF,
Weischer M,
Bisbjerg R,
Røder MA,
Iversen P,
Brenner H,
Cuk K,
Holleczek B,
Maier C,
Luedeke M,
Schnoeller T,
Kim J,
Logothetis CJ,
John EM,
Teixeira MR,
Paulo P,
Cardoso M,
Neuhausen SL,
Steele L,
Ding YC,
De Ruyck K,
De Meerleer G,
Ost P,
Razack A,
Lim J,
Teo SH,
Lin DW,
Newcomb LF,
Lessel D,
Gamulin M,
Kulis T,
Kaneva R,
Usmani N,
Singhal S,
Slavov C,
Mitev V,
Parliament M,
Claessens F,
Joniau S,
Van den Broeck T,
Larkin S,
Townsend PA,
Aukim-Hastie C,
Gago-Dominguez M,
Castelao JE,
Martinez ME,
Roobol MJ,
Jenster G,
van Schaik RHN,
Menegaux F,
Truong T,
Koudou YA,
Xu J,
Khaw KT,
Cannon-Albright L,
Pandha H,
Michael A,
Thibodeau SN,
McDonnell SK,
Schaid DJ,
Lindstrom S,
Turman C,
Ma J,
Hunter DJ,
Riboli E,
Siddiq A,
Canzian F,
Kolonel LN,
Le Marchand L,
Hoover RN,
Machiela MJ,
Cui Z,
Kraft P,
Amos CI,
Conti DV,
Easton DF,
Wiklund F,
Chanock SJ,
Henderson BE,
Kote-Jarai Z,
Haiman CA,
Eeles RA;
Profile Study;
Australian Prostate Cancer BioResource (APCB);
IMPACT Study;
Canary PASS Investigators;
Breast and Prostate Cancer Cohort Consortium (BPC3);
PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium;
Cancer of the Prostate in Sweden (CAPS);
Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS);
Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2018 Jul;50(7):928-936.
Epub 2018 Jun 11
doi: 10.1038/s41588-018-0142-8.
<span class="bold">PMID: </span><a href="/pubmed/29892016" target="_blank">29892016</a><a href="/pmc/articles/PMC6568012" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2C%20hereditary%2C%202%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (245)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/36434163">Germline mutations in prostate cancer: a systematic review of the evidence for personalized medicine.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Marino F,
Totaro A,
Gandi C,
Bientinesi R,
Moretto S,
Gavi F,
Pierconti F,
Iacovelli R,
Bassi P,
Sacco E</span><br />
<span class="medgenPMjournal">Prostate Cancer Prostatic Dis</span>
2023 Dec;26(4):655-664.
Epub 2022 Nov 24
doi: 10.1038/s41391-022-00609-3.
<span class="bold">PMID: </span><a href="/pubmed/36434163" target="_blank">36434163</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34577828">BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lee YC,
Lee YL,
Li CY</span><br />
<span class="medgenPMjournal">Medicina (Kaunas)</span>
2021 Aug 30;57(9)
doi: 10.3390/medicina57090905.
<span class="bold">PMID: </span><a href="/pubmed/34577828" target="_blank">34577828</a><a href="/pmc/articles/PMC8464901" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30527799">Homeobox B13 G84E Mutation and Prostate Cancer Risk.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nyberg T,
Govindasami K,
Leslie G,
Dadaev T,
Bancroft E,
Ni Raghallaigh H,
Brook MN,
Hussain N,
Keating D,
Lee A,
McMahon R,
Morgan A,
Mullen A,
Osborne A,
Rageevakumar R;
UK Genetic Prostate Cancer Study Collaborators,
Kote-Jarai Z,
Eeles R,
Antoniou AC</span><br />
<span class="medgenPMjournal">Eur Urol</span>
2019 May;75(5):834-845.
Epub 2018 Dec 8
doi: 10.1016/j.eururo.2018.11.015.
<span class="bold">PMID: </span><a href="/pubmed/30527799" target="_blank">30527799</a><a href="/pmc/articles/PMC6470122" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24425144">Risk of prostate cancer in Lynch syndrome: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ryan S,
Jenkins MA,
Win AK</span><br />
<span class="medgenPMjournal">Cancer Epidemiol Biomarkers Prev</span>
2014 Mar;23(3):437-49.
Epub 2014 Jan 14
doi: 10.1158/1055-9965.EPI-13-1165.
<span class="bold">PMID: </span><a href="/pubmed/24425144" target="_blank">24425144</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21715604">A systematic review of replication studies of prostate cancer susceptibility genetic variants in high-risk men originally identified from genome-wide association studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ishak MB,
Giri VN</span><br />
<span class="medgenPMjournal">Cancer Epidemiol Biomarkers Prev</span>
2011 Aug;20(8):1599-610.
Epub 2011 Jun 29
doi: 10.1158/1055-9965.EPI-11-0312.
<span class="bold">PMID: </span><a href="/pubmed/21715604" target="_blank">21715604</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2C%20hereditary%2C%202%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div></div>
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<div class="supplemental col three_col last">
<h2 class="offscreen_noflow">Supplemental Content</h2>
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<!-- MedGen supplemental column starts here -->
<div class="rightCol mgCol">
<div class="portlet mgSection" id="ID_113">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet mgSection" id="ID_106">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C3539120%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (15)</a></li>
<li><a href="/gtr/tests?term=C3539120%5bDISCUI%5d&amp;filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
<li><a href="/gtr/tests?term=C3539120%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (17)</a></li>
<li><a href="/gtr/tests?term=C3539120%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C3539120%5bDISCUI%5d" target="_blank">See all (18)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=614731" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Prostate%20cancer,%20hereditary,%202" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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