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<meta name="keywords" content="C2748055, disease or syndrome, hypoinsulinemia, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A decreased concentration of insulin in the blood." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=852189
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ConceptID=C2748055
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hypoinsulinemia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>852189</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2748055</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0040216">HP:0040216</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">A decreased concentration of insulin in the blood. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Hypoinsulinemia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/893021" ref="tree=MeSH" title="MedGen record for Abnormality of the endocrine system">Abnormality of the endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/871176" ref="tree=MeSH" title="MedGen record for Abnormal circulating hormone concentration">Abnormal circulating hormone concentration</a></span><ul><li><span class="TLline"><a href="/medgen/893016" ref="tree=MeSH" title="MedGen record for Abnormal circulating insulin concentration">Abnormal circulating insulin concentration</a></span><ul><li><span class="matched_ds">Hypoinsulinemia</span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
</div>
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||
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||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_318777"><div><strong>Obesity due to prohormone convertase I deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>318777</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833053</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Proprotein convertase-1/3 deficiency is an autosomal recessive disorder characterized by neonatal severe generalized malabsorptive diarrhea and failure to thrive. As the disease progresses, additional endocrine abnormalities develop, including diabetes insipidus, growth hormone deficiency, primary hypogonadism, adrenal insufficiency, and hypothyroidism (summary by Wilschanski et al., 2014).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/318777">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_383033"><div><strong>Maturity-onset diabetes of the young type 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>383033</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2677132</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Maturity-onset diabetes of the young (MODY) is a group of several conditions characterized by abnormally high levels of blood glucose, also called blood sugar. These forms of diabetes typically begin before age 30, although they can occur later in life. In MODY, elevated blood glucose arises from reduced production of insulin, which is a hormone produced in the pancreas that helps regulate blood glucose levels. Specifically, insulin controls how much glucose (a type of sugar) is passed from the blood into cells, where it is used as an energy source.\n\nRCAD is associated with a combination of diabetes and kidney or urinary tract abnormalities (unrelated to the elevated blood glucose), most commonly fluid-filled sacs (cysts) in the kidneys. However, the signs and symptoms are variable, even within families, and not everyone with RCAD has both features. Affected individuals may have other features unrelated to diabetes, such as abnormalities of the pancreas or liver or a form of arthritis called gout.\n\nThe different types of MODY are distinguished by their genetic causes. The most common types are HNF1A-MODY (also known as MODY3), accounting for 50 to 70 percent of cases, and GCK-MODY (MODY2), accounting for 30 to 50 percent of cases. Less frequent types include HNF4A-MODY (MODY1) and renal cysts and diabetes (RCAD) syndrome (also known as HNF1B-MODY or MODY5), which each account for 5 to 10 percent of cases. At least ten other types have been identified, and these are very rare.\n\nHNF1A-MODY and HNF4A-MODY have similar signs and symptoms that develop slowly over time. Early signs and symptoms in these types are caused by high blood glucose and may include frequent urination (polyuria), excessive thirst (polydipsia), fatigue, blurred vision, weight loss, and recurrent skin infections. Over time uncontrolled high blood glucose can damage small blood vessels in the eyes and kidneys. Damage to the light-sensitive tissue at the back of the eye (the retina) causes a condition known as diabetic retinopathy that can lead to vision loss and eventual blindness. Kidney damage (diabetic nephropathy) can lead to kidney failure and end-stage renal disease (ESRD). While these two types of MODY are very similar, certain features are particular to each type. For example, babies with HNF4A-MODY tend to weigh more than average or have abnormally low blood glucose at birth, even though other signs of the condition do not occur until childhood or young adulthood. People with HNF1A-MODY have a higher-than-average risk of developing noncancerous (benign) liver tumors known as hepatocellular adenomas.\n\nGCK-MODY is a very mild type of the condition. People with this type have slightly elevated blood glucose levels, particularly in the morning before eating (fasting blood glucose). However, affected individuals often have no symptoms related to the disorder, and diabetes-related complications are extremely rare.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/383033">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_480014"><div><strong>Hypoinsulinemic hypoglycemia and body hemihypertrophy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>480014</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3278384</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypoinsulinemic hypoglycemia and body hemihypertrophy is a rare, genetic, endocrine disease characterized by neonatal macrosomia, asymmetrical overgrowth (typically manifesting as left-sided hemihypertrophy) and recurrent, severe hypoinsulinemic (or hypoketotic hypo-fatty-acidemic) hypoglycemia in infancy, which results in episodes of reduced consciousness and seizures.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/480014">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_864147"><div><strong>Tenorio syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864147</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015710</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tenorio syndrome (TNORS) is characterized by overgrowth, macrocephaly, and impaired intellectual development. Some patients may have mild hydrocephaly, hypoglycemia, and inflammatory diseases resembling Sjogren syndrome (270150) (summary by Tenorio et al., 2014).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/864147">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_480014" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypoinsulinemic hypoglycemia and body hemihypertrophy</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_383033" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Maturity-onset diabetes of the young type 9</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_318777" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Obesity due to prohormone convertase I deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_864147" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tenorio syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37778510">APOE-Genotype and Insulin Modulate Estimated Effect of Dietary Macronutrients on Cognitive Performance: Panel Analyses in Nondiabetic Older Adults at Risk of Dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Norgren J,
|
||
Sindi S,
|
||
Matton A,
|
||
Kivipelto M,
|
||
Kåreholt I</span><br />
|
||
<span class="medgenPMjournal">J Nutr</span>
|
||
2023 Dec;153(12):3506-3520.
|
||
Epub 2023 Sep 29
|
||
doi: 10.1016/j.tjnut.2023.09.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37778510" target="_blank">37778510</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25863666">Bone health in type 1 diabetes: focus on evaluation and treatment in clinical practice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhukouskaya VV,
|
||
Eller-Vainicher C,
|
||
Shepelkevich AP,
|
||
Dydyshko Y,
|
||
Cairoli E,
|
||
Chiodini I</span><br />
|
||
<span class="medgenPMjournal">J Endocrinol Invest</span>
|
||
2015 Sep;38(9):941-50.
|
||
Epub 2015 Apr 12
|
||
doi: 10.1007/s40618-015-0284-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25863666" target="_blank">25863666</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7584526">Perioperative management of the diabetic patient.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peters A,
|
||
Kerner W</span><br />
|
||
<span class="medgenPMjournal">Exp Clin Endocrinol Diabetes</span>
|
||
1995;103(4):213-8.
|
||
doi: 10.1055/s-0029-1211353.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7584526" target="_blank">7584526</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hypoinsulinemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (8)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37428642">Cancer in growth hormone excess and growth hormone deficit.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guevara-Aguirre J,
|
||
Peña G,
|
||
Acosta W,
|
||
Pazmiño G,
|
||
Saavedra J,
|
||
Soto L,
|
||
Lescano D,
|
||
Guevara A,
|
||
Gavilanes AWD</span><br />
|
||
<span class="medgenPMjournal">Endocr Relat Cancer</span>
|
||
2023 Oct 1;30(10)
|
||
Epub 2023 Aug 14
|
||
doi: 10.1530/ERC-22-0402.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37428642" target="_blank">37428642</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25410210">Epidemiology of polyneuropathy in diabetes and prediabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ziegler D,
|
||
Papanas N,
|
||
Vinik AI,
|
||
Shaw JE</span><br />
|
||
<span class="medgenPMjournal">Handb Clin Neurol</span>
|
||
2014;126:3-22.
|
||
doi: 10.1016/B978-0-444-53480-4.00001-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25410210" target="_blank">25410210</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23112111">Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Elena JW,
|
||
Steplowski E,
|
||
Yu K,
|
||
Hartge P,
|
||
Tobias GS,
|
||
Brotzman MJ,
|
||
Chanock SJ,
|
||
Stolzenberg-Solomon RZ,
|
||
Arslan AA,
|
||
Bueno-de-Mesquita HB,
|
||
Helzlsouer K,
|
||
Jacobs EJ,
|
||
LaCroix A,
|
||
Petersen G,
|
||
Zheng W,
|
||
Albanes D,
|
||
Allen NE,
|
||
Amundadottir L,
|
||
Bao Y,
|
||
Boeing H,
|
||
Boutron-Ruault MC,
|
||
Buring JE,
|
||
Gaziano JM,
|
||
Giovannucci EL,
|
||
Duell EJ,
|
||
Hallmans G,
|
||
Howard BV,
|
||
Hunter DJ,
|
||
Hutchinson A,
|
||
Jacobs KB,
|
||
Kooperberg C,
|
||
Kraft P,
|
||
Mendelsohn JB,
|
||
Michaud DS,
|
||
Palli D,
|
||
Phillips LS,
|
||
Overvad K,
|
||
Patel AV,
|
||
Sansbury L,
|
||
Shu XO,
|
||
Simon MS,
|
||
Slimani N,
|
||
Trichopoulos D,
|
||
Visvanathan K,
|
||
Virtamo J,
|
||
Wolpin BM,
|
||
Zeleniuch-Jacquotte A,
|
||
Fuchs CS,
|
||
Hoover RN,
|
||
Gross M</span><br />
|
||
<span class="medgenPMjournal">Cancer Causes Control</span>
|
||
2013 Jan;24(1):13-25.
|
||
Epub 2012 Oct 31
|
||
doi: 10.1007/s10552-012-0078-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23112111" target="_blank">23112111</a><a href="/pmc/articles/PMC3529822" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6351588">Glucose tolerance in subclinical pyridoxine deficiency in man.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rao RH</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Nutr</span>
|
||
1983 Sep;38(3):440-4.
|
||
doi: 10.1093/ajcn/38.3.440.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6351588" target="_blank">6351588</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/5529067">Starvation in human pregnancy: hypoglycemia, hypoinsulinemia, and hyperketonemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Felig P,
|
||
Lynch V</span><br />
|
||
<span class="medgenPMjournal">Science</span>
|
||
1970 Nov 27;170(3961):990-2.
|
||
doi: 10.1126/science.170.3961.990.
|
||
<span class="bold">PMID: </span><a href="/pubmed/5529067" target="_blank">5529067</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoinsulinemia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (84)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/25410210">Epidemiology of polyneuropathy in diabetes and prediabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ziegler D,
|
||
Papanas N,
|
||
Vinik AI,
|
||
Shaw JE</span><br />
|
||
<span class="medgenPMjournal">Handb Clin Neurol</span>
|
||
2014;126:3-22.
|
||
doi: 10.1016/B978-0-444-53480-4.00001-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25410210" target="_blank">25410210</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18948730">Insulin and aging.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bartke A</span><br />
|
||
<span class="medgenPMjournal">Cell Cycle</span>
|
||
2008 Nov 1;7(21):3338-43.
|
||
Epub 2008 Nov 15
|
||
doi: 10.4161/cc.7.21.7012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18948730" target="_blank">18948730</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11119013">Postprandial reactive hypoglycemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brun JF,
|
||
Fedou C,
|
||
Mercier J</span><br />
|
||
<span class="medgenPMjournal">Diabetes Metab</span>
|
||
2000 Nov;26(5):337-51.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11119013" target="_blank">11119013</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2210061">Family of glucose-transporter genes. Implications for glucose homeostasis and diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mueckler M</span><br />
|
||
<span class="medgenPMjournal">Diabetes</span>
|
||
1990 Jan;39(1):6-11.
|
||
doi: 10.2337/diacare.39.1.6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2210061" target="_blank">2210061</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/992227">Insulin, glucagon, and somatostatin in normal physiology and diabetes mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Felig P,
|
||
Wahren J,
|
||
Sherwin R,
|
||
Hendler R</span><br />
|
||
<span class="medgenPMjournal">Diabetes</span>
|
||
1976 Dec;25(12):1091-9.
|
||
doi: 10.2337/diab.25.12.1091.
|
||
<span class="bold">PMID: </span><a href="/pubmed/992227" target="_blank">992227</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoinsulinemia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (67)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32679015">An Insight into Unani Hypoglycemic Drugs and Their Mechanism of Action.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fazil M,
|
||
Nikhat S,
|
||
Ali I</span><br />
|
||
<span class="medgenPMjournal">Comb Chem High Throughput Screen</span>
|
||
2021;24(2):165-176.
|
||
doi: 10.2174/1386207323666200717143540.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32679015" target="_blank">32679015</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32208563">Insulin: A Growth Hormone and Potential Oncogene.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Laron Z,
|
||
Werner H</span><br />
|
||
<span class="medgenPMjournal">Pediatr Endocrinol Rev</span>
|
||
2020 Mar;17(Suppl 1):191-197.
|
||
doi: 10.17458/per.vol17.2020.lw.insulinghpotentialoncogene.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32208563" target="_blank">32208563</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29514131">Potential of resveratrol in mitigating metabolic disturbances induced by ethanol.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szkudelski T,
|
||
Szkudelska K</span><br />
|
||
<span class="medgenPMjournal">Biomed Pharmacother</span>
|
||
2018 May;101:579-584.
|
||
Epub 2018 Mar 22
|
||
doi: 10.1016/j.biopha.2018.02.063.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29514131" target="_blank">29514131</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24005018">Comparison of the enhancement of plasma glucose levels in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats by oral administration of sucrose or maple syrup.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nagai N,
|
||
Ito Y,
|
||
Taga A</span><br />
|
||
<span class="medgenPMjournal">J Oleo Sci</span>
|
||
2013;62(9):737-43.
|
||
doi: 10.5650/jos.62.737.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24005018" target="_blank">24005018</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6351588">Glucose tolerance in subclinical pyridoxine deficiency in man.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rao RH</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Nutr</span>
|
||
1983 Sep;38(3):440-4.
|
||
doi: 10.1093/ajcn/38.3.440.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6351588" target="_blank">6351588</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoinsulinemia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (62)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37778510">APOE-Genotype and Insulin Modulate Estimated Effect of Dietary Macronutrients on Cognitive Performance: Panel Analyses in Nondiabetic Older Adults at Risk of Dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Norgren J,
|
||
Sindi S,
|
||
Matton A,
|
||
Kivipelto M,
|
||
Kåreholt I</span><br />
|
||
<span class="medgenPMjournal">J Nutr</span>
|
||
2023 Dec;153(12):3506-3520.
|
||
Epub 2023 Sep 29
|
||
doi: 10.1016/j.tjnut.2023.09.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37778510" target="_blank">37778510</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20232652">Bone mineral density and fracture risk in patients with type 1 and type 2 diabetes mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Botushanov NP,
|
||
Orbetzova MM</span><br />
|
||
<span class="medgenPMjournal">Folia Med (Plovdiv)</span>
|
||
2009 Oct-Dec;51(4):12-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20232652" target="_blank">20232652</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1425088">Permanent diabetes without serological evidence of autoimmunity after transient neonatal diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gottschalk ME,
|
||
Schatz DA,
|
||
Clare-Salzler M,
|
||
Kaufman DL,
|
||
Ting GS,
|
||
Geffner ME</span><br />
|
||
<span class="medgenPMjournal">Diabetes Care</span>
|
||
1992 Oct;15(10):1273-6.
|
||
doi: 10.2337/diacare.15.10.1273.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1425088" target="_blank">1425088</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2215253">Impaired glucose tolerance and diabetes in obesity: a 6-year follow-up study of glucose metabolism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jallut D,
|
||
Golay A,
|
||
Munger R,
|
||
Frascarolo P,
|
||
Schutz Y,
|
||
Jéquier E,
|
||
Felber JP</span><br />
|
||
<span class="medgenPMjournal">Metabolism</span>
|
||
1990 Oct;39(10):1068-75.
|
||
doi: 10.1016/0026-0495(90)90168-c.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2215253" target="_blank">2215253</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3532796">A link between relative hypoglycemia-hypoinsulinemia during oral glucose tolerance tests and intrauterine growth retardation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Langer O,
|
||
Damus K,
|
||
Maiman M,
|
||
Divon M,
|
||
Levy J,
|
||
Bauman W</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
1986 Oct;155(4):711-6.
|
||
doi: 10.1016/s0002-9378(86)80004-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3532796" target="_blank">3532796</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoinsulinemia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37428642">Cancer in growth hormone excess and growth hormone deficit.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guevara-Aguirre J,
|
||
Peña G,
|
||
Acosta W,
|
||
Pazmiño G,
|
||
Saavedra J,
|
||
Soto L,
|
||
Lescano D,
|
||
Guevara A,
|
||
Gavilanes AWD</span><br />
|
||
<span class="medgenPMjournal">Endocr Relat Cancer</span>
|
||
2023 Oct 1;30(10)
|
||
Epub 2023 Aug 14
|
||
doi: 10.1530/ERC-22-0402.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37428642" target="_blank">37428642</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25550458">Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kinross KM,
|
||
Montgomery KG,
|
||
Mangiafico SP,
|
||
Hare LM,
|
||
Kleinschmidt M,
|
||
Bywater MJ,
|
||
Poulton IJ,
|
||
Vrahnas C,
|
||
Henneicke H,
|
||
Malaterre J,
|
||
Waring PM,
|
||
Cullinane C,
|
||
Sims NA,
|
||
McArthur GA,
|
||
Andrikopoulos S,
|
||
Phillips WA</span><br />
|
||
<span class="medgenPMjournal">FASEB J</span>
|
||
2015 Apr;29(4):1426-34.
|
||
Epub 2014 Dec 30
|
||
doi: 10.1096/fj.14-262782.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25550458" target="_blank">25550458</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19199940">Role of innate immunity in triggering and tuning of autoimmune diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim HS,
|
||
Lee MS</span><br />
|
||
<span class="medgenPMjournal">Curr Mol Med</span>
|
||
2009 Feb;9(1):30-44.
|
||
doi: 10.2174/156652409787314471.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19199940" target="_blank">19199940</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3530856">Rubella virus-induced diabetes in the hamster.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rayfield EJ,
|
||
Kelly KJ,
|
||
Yoon JW</span><br />
|
||
<span class="medgenPMjournal">Diabetes</span>
|
||
1986 Nov;35(11):1278-81.
|
||
doi: 10.2337/diab.35.11.1278.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3530856" target="_blank">3530856</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/992227">Insulin, glucagon, and somatostatin in normal physiology and diabetes mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Felig P,
|
||
Wahren J,
|
||
Sherwin R,
|
||
Hendler R</span><br />
|
||
<span class="medgenPMjournal">Diabetes</span>
|
||
1976 Dec;25(12):1091-9.
|
||
doi: 10.2337/diab.25.12.1091.
|
||
<span class="bold">PMID: </span><a href="/pubmed/992227" target="_blank">992227</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoinsulinemia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (62)</a></div></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/37085712">Insulin effects on core neurotransmitter pathways involved in schizophrenia neurobiology: a meta-analysis of preclinical studies. Implications for the treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">de Bartolomeis A,
|
||
De Simone G,
|
||
De Prisco M,
|
||
Barone A,
|
||
Napoli R,
|
||
Beguinot F,
|
||
Billeci M,
|
||
Fornaro M</span><br />
|
||
<span class="medgenPMjournal">Mol Psychiatry</span>
|
||
2023 Jul;28(7):2811-2825.
|
||
Epub 2023 Apr 21
|
||
doi: 10.1038/s41380-023-02065-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37085712" target="_blank">37085712</a><a href="/pmc/articles/PMC10615753" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoinsulinemia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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