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<meta name="keywords" content="C2700438, bipolar affective disorder, mafd7, major affective disorder 7, major affective disorder type 7, major affective disorder-7, susceptibility to, mental or behavioral dysfunction, xbp1, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Bipolar disorder often occurs with other mental health conditions, including anxiety disorders (such as panic attacks), behavioral disorders (such as attention-deficit/hyperactivity disorder), and substance abuse.\n\nBipolar disorder is classified into several types based on the mood changes that occur. Bipolar I involves manic episodes, which can be accompanied by psychotic symptoms, and hypomanic or depressive episodes. Bipolar II involves hypomanic episodes and depressive episodes. Cyclothymic disorder involves hypomanic episodes and depressive episodes that are typically less severe than those in bipolar I or bipolar II.\n\nManic and depressive episodes can include psychotic symptoms, such as false perceptions (hallucinations) or strongly held false beliefs (delusions). Mixed episodes, which have features of manic and depressive episodes at the same time, also occur in some affected individuals.\n\nDepressive episodes are marked by low energy and activity, a feeling of hopelessness, and an inability to perform everyday tasks. People with bipolar disorder often have repeated thoughts of death and suicide, and they have a much greater risk of dying by suicide than the general population.\n\nManic episodes are characterized by increased energy and activity, irritability, restlessness, an inability to sleep, and reckless behavior. Some people with bipolar disorder experience hypomanic episodes, which are similar to but less extreme than manic episodes.\n\nPeople with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes. These episodes can last from hours to weeks, and many people have no symptoms between episodes.\n\nBipolar disorder is a mental health condition that causes extreme shifts in mood, energy, and behavior. This disorder most often appears in late adolescence or early adulthood, although symptoms can begin at any time of life." /><meta name="robots" content="index,nofollow,noarchive" />
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|
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<!--
|
||
UID=438008
|
||
ConceptID=C2700438
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Major affective disorder 7<span class="h1sub">(MAFD7)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>438008</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2700438</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>MAFD7</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="XBP1 - ID: 7494 - NCBI Gene" href="/gene/7494" class="medgenPMinfo">XBP1</a> (22q12.1)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0012881" target="_blank">MONDO:0012881</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/612371" target="_blank">612371</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Bipolar disorder often occurs with other mental health conditions, including anxiety disorders (such as panic attacks), behavioral disorders (such as attention-deficit/hyperactivity disorder), and substance abuse.<br /><br />Bipolar disorder is classified into several types based on the mood changes that occur. Bipolar I involves manic episodes, which can be accompanied by psychotic symptoms, and hypomanic or depressive episodes. Bipolar II involves hypomanic episodes and depressive episodes. Cyclothymic disorder involves hypomanic episodes and depressive episodes that are typically less severe than those in bipolar I or bipolar II.<br /><br />Manic and depressive episodes can include psychotic symptoms, such as false perceptions (hallucinations) or strongly held false beliefs (delusions). Mixed episodes, which have features of manic and depressive episodes at the same time, also occur in some affected individuals.<br /><br />Depressive episodes are marked by low energy and activity, a feeling of hopelessness, and an inability to perform everyday tasks. People with bipolar disorder often have repeated thoughts of death and suicide, and they have a much greater risk of dying by suicide than the general population.<br /><br />Manic episodes are characterized by increased energy and activity, irritability, restlessness, an inability to sleep, and reckless behavior. Some people with bipolar disorder experience hypomanic episodes, which are similar to but less extreme than manic episodes.<br /><br />People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes. These episodes can last from hours to weeks, and many people have no symptoms between episodes.<br /><br />Bipolar disorder is a mental health condition that causes extreme shifts in mood, energy, and behavior. This disorder most often appears in late adolescence or early adulthood, although symptoms can begin at any time of life. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34459676">Treatment-Resistant Depression: Approaches to Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kverno KS,
|
||
Mangano E</span><br />
|
||
<span class="medgenPMjournal">J Psychosoc Nurs Ment Health Serv</span>
|
||
2021 Sep;59(9):7-11.
|
||
Epub 2021 Sep 1
|
||
doi: 10.3928/02793695-20210816-01.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34459676" target="_blank">34459676</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31760505">Psychological Treatment of Depression in Primary Care: Recent Developments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cuijpers P,
|
||
Quero S,
|
||
Dowrick C,
|
||
Arroll B</span><br />
|
||
<span class="medgenPMjournal">Curr Psychiatry Rep</span>
|
||
2019 Nov 23;21(12):129.
|
||
doi: 10.1007/s11920-019-1117-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31760505" target="_blank">31760505</a><a href="/pmc/articles/PMC6875158" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30453134">Updated European Consensus Statement on diagnosis and treatment of adult ADHD.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kooij JJS,
|
||
Bijlenga D,
|
||
Salerno L,
|
||
Jaeschke R,
|
||
Bitter I,
|
||
Balázs J,
|
||
Thome J,
|
||
Dom G,
|
||
Kasper S,
|
||
Nunes Filipe C,
|
||
Stes S,
|
||
Mohr P,
|
||
Leppämäki S,
|
||
Casas M,
|
||
Bobes J,
|
||
Mccarthy JM,
|
||
Richarte V,
|
||
Kjems Philipsen A,
|
||
Pehlivanidis A,
|
||
Niemela A,
|
||
Styr B,
|
||
Semerci B,
|
||
Bolea-Alamanac B,
|
||
Edvinsson D,
|
||
Baeyens D,
|
||
Wynchank D,
|
||
Sobanski E,
|
||
Philipsen A,
|
||
McNicholas F,
|
||
Caci H,
|
||
Mihailescu I,
|
||
Manor I,
|
||
Dobrescu I,
|
||
Saito T,
|
||
Krause J,
|
||
Fayyad J,
|
||
Ramos-Quiroga JA,
|
||
Foeken K,
|
||
Rad F,
|
||
Adamou M,
|
||
Ohlmeier M,
|
||
Fitzgerald M,
|
||
Gill M,
|
||
Lensing M,
|
||
Motavalli Mukaddes N,
|
||
Brudkiewicz P,
|
||
Gustafsson P,
|
||
Tani P,
|
||
Oswald P,
|
||
Carpentier PJ,
|
||
De Rossi P,
|
||
Delorme R,
|
||
Markovska Simoska S,
|
||
Pallanti S,
|
||
Young S,
|
||
Bejerot S,
|
||
Lehtonen T,
|
||
Kustow J,
|
||
Müller-Sedgwick U,
|
||
Hirvikoski T,
|
||
Pironti V,
|
||
Ginsberg Y,
|
||
Félegyházy Z,
|
||
Garcia-Portilla MP,
|
||
Asherson P</span><br />
|
||
<span class="medgenPMjournal">Eur Psychiatry</span>
|
||
2019 Feb;56:14-34.
|
||
Epub 2018 Nov 16
|
||
doi: 10.1016/j.eurpsy.2018.11.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30453134" target="_blank">30453134</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(major%20affective%20disorder%207)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1242)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/cg185" target="_blank">UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37878349">Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tomasik J,
|
||
Harrison SJ,
|
||
Rustogi N,
|
||
Olmert T,
|
||
Barton-Owen G,
|
||
Han SYS,
|
||
Cooper JD,
|
||
Eljasz P,
|
||
Farrag LP,
|
||
Friend LV,
|
||
Bell E,
|
||
Cowell D,
|
||
Bahn S</span><br />
|
||
<span class="medgenPMjournal">JAMA Psychiatry</span>
|
||
2024 Jan 1;81(1):101-106.
|
||
doi: 10.1001/jamapsychiatry.2023.4096.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37878349" target="_blank">37878349</a><a href="/pmc/articles/PMC10600716" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37314797">Acceptability, Tolerability, and Estimates of Putative Treatment Effects of Probiotics as Adjunctive Treatment in Patients With Depression: A Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nikolova VL,
|
||
Cleare AJ,
|
||
Young AH,
|
||
Stone JM</span><br />
|
||
<span class="medgenPMjournal">JAMA Psychiatry</span>
|
||
2023 Aug 1;80(8):842-847.
|
||
doi: 10.1001/jamapsychiatry.2023.1817.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37314797" target="_blank">37314797</a><a href="/pmc/articles/PMC10267847" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33899528">Thyroid Function and Mood Disorders: A Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuś A,
|
||
Kjaergaard AD,
|
||
Marouli E,
|
||
Del Greco M F,
|
||
Sterenborg RBTM,
|
||
Chaker L,
|
||
Peeters RP,
|
||
Bednarczuk T,
|
||
Åsvold BO,
|
||
Burgess S,
|
||
Deloukas P,
|
||
Teumer A,
|
||
Ellervik C,
|
||
Medici M</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2021 Aug;31(8):1171-1181.
|
||
Epub 2021 May 26
|
||
doi: 10.1089/thy.2020.0884.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33899528" target="_blank">33899528</a><a href="/pmc/articles/PMC7612998" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33528847">Prevalence of attention-deficit/hyperactivity disorder in people with mood disorders: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sandstrom A,
|
||
Perroud N,
|
||
Alda M,
|
||
Uher R,
|
||
Pavlova B</span><br />
|
||
<span class="medgenPMjournal">Acta Psychiatr Scand</span>
|
||
2021 May;143(5):380-391.
|
||
Epub 2021 Feb 15
|
||
doi: 10.1111/acps.13283.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33528847" target="_blank">33528847</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22865617">Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kessler RC,
|
||
Petukhova M,
|
||
Sampson NA,
|
||
Zaslavsky AM,
|
||
Wittchen H -U</span><br />
|
||
<span class="medgenPMjournal">Int J Methods Psychiatr Res</span>
|
||
2012 Sep;21(3):169-84.
|
||
Epub 2012 Aug 1
|
||
doi: 10.1002/mpr.1359.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22865617" target="_blank">22865617</a><a href="/pmc/articles/PMC4005415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Major%20affective%20disorder%207%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7383)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37878349">Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tomasik J,
|
||
Harrison SJ,
|
||
Rustogi N,
|
||
Olmert T,
|
||
Barton-Owen G,
|
||
Han SYS,
|
||
Cooper JD,
|
||
Eljasz P,
|
||
Farrag LP,
|
||
Friend LV,
|
||
Bell E,
|
||
Cowell D,
|
||
Bahn S</span><br />
|
||
<span class="medgenPMjournal">JAMA Psychiatry</span>
|
||
2024 Jan 1;81(1):101-106.
|
||
doi: 10.1001/jamapsychiatry.2023.4096.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37878349" target="_blank">37878349</a><a href="/pmc/articles/PMC10600716" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36853245">Borderline Personality Disorder: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leichsenring F,
|
||
Heim N,
|
||
Leweke F,
|
||
Spitzer C,
|
||
Steinert C,
|
||
Kernberg OF</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Feb 28;329(8):670-679.
|
||
doi: 10.1001/jama.2023.0589.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36853245" target="_blank">36853245</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33528847">Prevalence of attention-deficit/hyperactivity disorder in people with mood disorders: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sandstrom A,
|
||
Perroud N,
|
||
Alda M,
|
||
Uher R,
|
||
Pavlova B</span><br />
|
||
<span class="medgenPMjournal">Acta Psychiatr Scand</span>
|
||
2021 May;143(5):380-391.
|
||
Epub 2021 Feb 15
|
||
doi: 10.1111/acps.13283.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33528847" target="_blank">33528847</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22865617">Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kessler RC,
|
||
Petukhova M,
|
||
Sampson NA,
|
||
Zaslavsky AM,
|
||
Wittchen H -U</span><br />
|
||
<span class="medgenPMjournal">Int J Methods Psychiatr Res</span>
|
||
2012 Sep;21(3):169-84.
|
||
Epub 2012 Aug 1
|
||
doi: 10.1002/mpr.1359.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22865617" target="_blank">22865617</a><a href="/pmc/articles/PMC4005415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15939839">Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kessler RC,
|
||
Chiu WT,
|
||
Demler O,
|
||
Merikangas KR,
|
||
Walters EE</span><br />
|
||
<span class="medgenPMjournal">Arch Gen Psychiatry</span>
|
||
2005 Jun;62(6):617-27.
|
||
doi: 10.1001/archpsyc.62.6.617.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15939839" target="_blank">15939839</a><a href="/pmc/articles/PMC2847357" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Major%20affective%20disorder%207%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6148)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37625365">Accelerated intermittent theta burst stimulation in major depressive disorder: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neuteboom D,
|
||
Zantvoord JB,
|
||
Goya-Maldonado R,
|
||
Wilkening J,
|
||
Dols A,
|
||
van Exel E,
|
||
Lok A,
|
||
de Haan L,
|
||
Scheepstra KWF</span><br />
|
||
<span class="medgenPMjournal">Psychiatry Res</span>
|
||
2023 Sep;327:115429.
|
||
Epub 2023 Aug 21
|
||
doi: 10.1016/j.psychres.2023.115429.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37625365" target="_blank">37625365</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37314797">Acceptability, Tolerability, and Estimates of Putative Treatment Effects of Probiotics as Adjunctive Treatment in Patients With Depression: A Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nikolova VL,
|
||
Cleare AJ,
|
||
Young AH,
|
||
Stone JM</span><br />
|
||
<span class="medgenPMjournal">JAMA Psychiatry</span>
|
||
2023 Aug 1;80(8):842-847.
|
||
doi: 10.1001/jamapsychiatry.2023.1817.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37314797" target="_blank">37314797</a><a href="/pmc/articles/PMC10267847" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33528847">Prevalence of attention-deficit/hyperactivity disorder in people with mood disorders: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sandstrom A,
|
||
Perroud N,
|
||
Alda M,
|
||
Uher R,
|
||
Pavlova B</span><br />
|
||
<span class="medgenPMjournal">Acta Psychiatr Scand</span>
|
||
2021 May;143(5):380-391.
|
||
Epub 2021 Feb 15
|
||
doi: 10.1111/acps.13283.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33528847" target="_blank">33528847</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31347611">Gepirone hydrochloride: a novel antidepressant with 5-HT1A agonistic properties.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaur Gill A,
|
||
Bansal Y,
|
||
Bhandari R,
|
||
Kaur S,
|
||
Kaur J,
|
||
Singh R,
|
||
Kuhad A,
|
||
Kuhad A</span><br />
|
||
<span class="medgenPMjournal">Drugs Today (Barc)</span>
|
||
2019 Jul;55(7):423-437.
|
||
doi: 10.1358/dot.2019.55.7.2958474.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31347611" target="_blank">31347611</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20370962">The sequenced treatment alternatives to relieve depression (STAR*D) trial: a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sinyor M,
|
||
Schaffer A,
|
||
Levitt A</span><br />
|
||
<span class="medgenPMjournal">Can J Psychiatry</span>
|
||
2010 Mar;55(3):126-35.
|
||
doi: 10.1177/070674371005500303.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20370962" target="_blank">20370962</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Major%20affective%20disorder%207%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5251)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35567871">A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schulte EC,
|
||
Kondofersky I,
|
||
Budde M,
|
||
Papiol S,
|
||
Senner F,
|
||
Schaupp SK,
|
||
Reich-Erkelenz D,
|
||
Klöhn-Saghatolislam F,
|
||
Kalman JL,
|
||
Gade K,
|
||
Hake M,
|
||
Comes AL,
|
||
Anderson-Schmidt H,
|
||
Adorjan K,
|
||
Juckel G,
|
||
Schmauß M,
|
||
Zimmermann J,
|
||
Reimer J,
|
||
Wiltfang J,
|
||
Reininghaus EZ,
|
||
Anghelescu IG,
|
||
Konrad C,
|
||
Figge C,
|
||
von Hagen M,
|
||
Jäger M,
|
||
Dietrich DE,
|
||
Spitzer C,
|
||
Witt SH,
|
||
Forstner AJ,
|
||
Rietschel M,
|
||
Nöthen MM,
|
||
Falkai P,
|
||
Heilbronner U,
|
||
Mueller NS,
|
||
Schulze TG</span><br />
|
||
<span class="medgenPMjournal">Schizophr Res</span>
|
||
2022 Jun;244:29-38.
|
||
Epub 2022 May 11
|
||
doi: 10.1016/j.schres.2022.05.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35567871" target="_blank">35567871</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33899528">Thyroid Function and Mood Disorders: A Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuś A,
|
||
Kjaergaard AD,
|
||
Marouli E,
|
||
Del Greco M F,
|
||
Sterenborg RBTM,
|
||
Chaker L,
|
||
Peeters RP,
|
||
Bednarczuk T,
|
||
Åsvold BO,
|
||
Burgess S,
|
||
Deloukas P,
|
||
Teumer A,
|
||
Ellervik C,
|
||
Medici M</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2021 Aug;31(8):1171-1181.
|
||
Epub 2021 May 26
|
||
doi: 10.1089/thy.2020.0884.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33899528" target="_blank">33899528</a><a href="/pmc/articles/PMC7612998" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32828168">Review of dysthymia and persistent depressive disorder: history, correlates, and clinical implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schramm E,
|
||
Klein DN,
|
||
Elsaesser M,
|
||
Furukawa TA,
|
||
Domschke K</span><br />
|
||
<span class="medgenPMjournal">Lancet Psychiatry</span>
|
||
2020 Sep;7(9):801-812.
|
||
doi: 10.1016/S2215-0366(20)30099-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32828168" target="_blank">32828168</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32451021">Telepsychiatry in Obstetrics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Worley LLM,
|
||
Wise-Ehlers A</span><br />
|
||
<span class="medgenPMjournal">Obstet Gynecol Clin North Am</span>
|
||
2020 Jun;47(2):333-340.
|
||
doi: 10.1016/j.ogc.2020.02.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32451021" target="_blank">32451021</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16260528">Perinatal depression: a systematic review of prevalence and incidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gavin NI,
|
||
Gaynes BN,
|
||
Lohr KN,
|
||
Meltzer-Brody S,
|
||
Gartlehner G,
|
||
Swinson T</span><br />
|
||
<span class="medgenPMjournal">Obstet Gynecol</span>
|
||
2005 Nov;106(5 Pt 1):1071-83.
|
||
doi: 10.1097/01.AOG.0000183597.31630.db.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16260528" target="_blank">16260528</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Major%20affective%20disorder%207%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3526)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37878349">Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tomasik J,
|
||
Harrison SJ,
|
||
Rustogi N,
|
||
Olmert T,
|
||
Barton-Owen G,
|
||
Han SYS,
|
||
Cooper JD,
|
||
Eljasz P,
|
||
Farrag LP,
|
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Friend LV,
|
||
Bell E,
|
||
Cowell D,
|
||
Bahn S</span><br />
|
||
<span class="medgenPMjournal">JAMA Psychiatry</span>
|
||
2024 Jan 1;81(1):101-106.
|
||
doi: 10.1001/jamapsychiatry.2023.4096.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37878349" target="_blank">37878349</a><a href="/pmc/articles/PMC10600716" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37314797">Acceptability, Tolerability, and Estimates of Putative Treatment Effects of Probiotics as Adjunctive Treatment in Patients With Depression: A Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nikolova VL,
|
||
Cleare AJ,
|
||
Young AH,
|
||
Stone JM</span><br />
|
||
<span class="medgenPMjournal">JAMA Psychiatry</span>
|
||
2023 Aug 1;80(8):842-847.
|
||
doi: 10.1001/jamapsychiatry.2023.1817.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37314797" target="_blank">37314797</a><a href="/pmc/articles/PMC10267847" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36853245">Borderline Personality Disorder: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leichsenring F,
|
||
Heim N,
|
||
Leweke F,
|
||
Spitzer C,
|
||
Steinert C,
|
||
Kernberg OF</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Feb 28;329(8):670-679.
|
||
doi: 10.1001/jama.2023.0589.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36853245" target="_blank">36853245</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33904154">Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Henter ID,
|
||
Park LT,
|
||
Zarate CA Jr</span><br />
|
||
<span class="medgenPMjournal">CNS Drugs</span>
|
||
2021 May;35(5):527-543.
|
||
Epub 2021 Apr 26
|
||
doi: 10.1007/s40263-021-00816-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33904154" target="_blank">33904154</a><a href="/pmc/articles/PMC8201267" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33899528">Thyroid Function and Mood Disorders: A Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuś A,
|
||
Kjaergaard AD,
|
||
Marouli E,
|
||
Del Greco M F,
|
||
Sterenborg RBTM,
|
||
Chaker L,
|
||
Peeters RP,
|
||
Bednarczuk T,
|
||
Åsvold BO,
|
||
Burgess S,
|
||
Deloukas P,
|
||
Teumer A,
|
||
Ellervik C,
|
||
Medici M</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2021 Aug;31(8):1171-1181.
|
||
Epub 2021 May 26
|
||
doi: 10.1089/thy.2020.0884.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33899528" target="_blank">33899528</a><a href="/pmc/articles/PMC7612998" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Major%20affective%20disorder%207%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5990)</a></div></div>
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|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37595997">Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yildiz A,
|
||
Siafis S,
|
||
Mavridis D,
|
||
Vieta E,
|
||
Leucht S</span><br />
|
||
<span class="medgenPMjournal">Lancet Psychiatry</span>
|
||
2023 Sep;10(9):693-705.
|
||
doi: 10.1016/S2215-0366(23)00199-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37595997" target="_blank">37595997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35416941">Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pearce M,
|
||
Garcia L,
|
||
Abbas A,
|
||
Strain T,
|
||
Schuch FB,
|
||
Golubic R,
|
||
Kelly P,
|
||
Khan S,
|
||
Utukuri M,
|
||
Laird Y,
|
||
Mok A,
|
||
Smith A,
|
||
Tainio M,
|
||
Brage S,
|
||
Woodcock J</span><br />
|
||
<span class="medgenPMjournal">JAMA Psychiatry</span>
|
||
2022 Jun 1;79(6):550-559.
|
||
doi: 10.1001/jamapsychiatry.2022.0609.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35416941" target="_blank">35416941</a><a href="/pmc/articles/PMC9008579" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33022440">Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bahji A,
|
||
Vazquez GH,
|
||
Zarate CA Jr</span><br />
|
||
<span class="medgenPMjournal">J Affect Disord</span>
|
||
2021 Jan 1;278:542-555.
|
||
Epub 2020 Sep 23
|
||
doi: 10.1016/j.jad.2020.09.071.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33022440" target="_blank">33022440</a><a href="/pmc/articles/PMC7704936" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30758486">Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gobbi G,
|
||
Atkin T,
|
||
Zytynski T,
|
||
Wang S,
|
||
Askari S,
|
||
Boruff J,
|
||
Ware M,
|
||
Marmorstein N,
|
||
Cipriani A,
|
||
Dendukuri N,
|
||
Mayo N</span><br />
|
||
<span class="medgenPMjournal">JAMA Psychiatry</span>
|
||
2019 Apr 1;76(4):426-434.
|
||
doi: 10.1001/jamapsychiatry.2018.4500.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30758486" target="_blank">30758486</a><a href="/pmc/articles/PMC6450286" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16260528">Perinatal depression: a systematic review of prevalence and incidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gavin NI,
|
||
Gaynes BN,
|
||
Lohr KN,
|
||
Meltzer-Brody S,
|
||
Gartlehner G,
|
||
Swinson T</span><br />
|
||
<span class="medgenPMjournal">Obstet Gynecol</span>
|
||
2005 Nov;106(5 Pt 1):1071-83.
|
||
doi: 10.1097/01.AOG.0000183597.31630.db.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16260528" target="_blank">16260528</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Major%20affective%20disorder%207%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (429)</a></div></div>
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C2700438%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
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<li><a href="/gtr/tests?term=C2700438%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (3)</a></li>
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<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Major+affective+disorder+7/8781" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/major_affective_disorder_7_2" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Major%20affective%20disorder%207" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/bipolar-disorder" target="_blank">MedlinePlusGenetics (GHR)</a></li></ul></div>
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<h3>Related information</h3>
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=438008" ref="log$=recordlinks">ClinVar</a>
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<div class="ralinkpop offscreen_noflow">C1853736[trait identifier] AND "ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories"[submitter]<div class="brieflinkpopdesc">Search</div></div>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
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