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<meta name="keywords" content="C2677501, fasting plasma glucose level quantitative trait locus 1, fgqtl1, finding, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Glucose is the major source of energy in humans, with levels in vivo determined by a balance of glucose absorption via the gut, production primarily by the liver, and utilization by both insulin-sensitive and insulin-insensitive tissues. Blood and plasma fasting glucose levels are tightly regulated within a narrow physiologic range by a feedback mechanism that targets a particular fasting glucose set point for each individual. Within healthy, nondiabetic populations there is substantial variation in fasting glucose levels. Approximately one-third of this variation is genetic. Disruption of normal glucose homeostasis and substantial elevations of fasting glucose are hallmarks of type 2 diabetes (T2D) and typically result from sustained reduction in pancreatic beta-cell function and insulin secretion (summary by Chen et al., 2008 and Prokopenko et al., 2009). Genetic Heterogeneity Genetic loci influencing fasting plasma glucose have been identified on 2q24-q32 (FGQTL1), related to single-nucleotide polymorphisms (SNPs) in the vicinity of the G6PC2 gene (608058); on 7p15-p13 (FGQTL2; 613219), related to SNPs in the vicinity of the glucokinase gene (GCK; 138079); on 11q21-q22 (FGQTL3; 613233), related to SNPs in the vicinity of the MTNR1B gene (600804); on 7p21.2 (FGQTL4; 613462), in the vicinity of the DGKB gene (604070); on 2p23.3-p23.2 (FGQTL5; 613463) due to variation in the GCKR gene (600842); and on 3q21 (FGQTL6; 613460), in the vicinity of the ADCY5 gene (600293). See 613219 for a discussion of birth weight as a quantitative trait, another glycemic-influenced trait with an effect on T2D risk. See also 606035 for a discussion of a fasting insulin quantitative trait locus on chromosome 6q22-q24." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=436961
|
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ConceptID=C2677501
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Fasting plasma glucose level quantitative trait locus 1<span class="h1sub">(FGQTL1)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>436961</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2677501</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>FGQTL1</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/612108" target="_blank">612108</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Glucose is the major source of energy in humans, with levels in vivo determined by a balance of glucose absorption via the gut, production primarily by the liver, and utilization by both insulin-sensitive and insulin-insensitive tissues. Blood and plasma fasting glucose levels are tightly regulated within a narrow physiologic range by a feedback mechanism that targets a particular fasting glucose set point for each individual. Within healthy, nondiabetic populations there is substantial variation in fasting glucose levels. Approximately one-third of this variation is genetic. Disruption of normal glucose homeostasis and substantial elevations of fasting glucose are hallmarks of type 2 diabetes (T2D) and typically result from sustained reduction in pancreatic beta-cell function and insulin secretion (summary by Chen et al., 2008 and Prokopenko et al., 2009). Genetic Heterogeneity Genetic loci influencing fasting plasma glucose have been identified on 2q24-q32 (FGQTL1), related to single-nucleotide polymorphisms (SNPs) in the vicinity of the G6PC2 gene (608058); on 7p15-p13 (FGQTL2; 613219), related to SNPs in the vicinity of the glucokinase gene (GCK; 138079); on 11q21-q22 (FGQTL3; 613233), related to SNPs in the vicinity of the MTNR1B gene (600804); on 7p21.2 (FGQTL4; 613462), in the vicinity of the DGKB gene (604070); on 2p23.3-p23.2 (FGQTL5; 613463) due to variation in the GCKR gene (600842); and on 3q21 (FGQTL6; 613460), in the vicinity of the ADCY5 gene (600293). See 613219 for a discussion of birth weight as a quantitative trait, another glycemic-influenced trait with an effect on T2D risk. See also 606035 for a discussion of a fasting insulin quantitative trait locus on chromosome 6q22-q24. [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/25213455">Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zheng JS,
|
||
Lai CQ,
|
||
Parnell LD,
|
||
Lee YC,
|
||
Shen J,
|
||
Smith CE,
|
||
Casas-Agustench P,
|
||
Richardson K,
|
||
Li D,
|
||
Noel SE,
|
||
Tucker KL,
|
||
Arnett DK,
|
||
Borecki IB,
|
||
Ordovás JM</span><br />
|
||
<span class="medgenPMjournal">BMC Genomics</span>
|
||
2014 Sep 11;15(1):781.
|
||
doi: 10.1186/1471-2164-15-781.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25213455" target="_blank">25213455</a><a href="/pmc/articles/PMC4168207" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(fasting%20plasma%20glucose%20level%20quantitative%20trait%20locus%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
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</div>
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||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
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to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
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<div class="portlet mgSection" id="ID_103">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38625888">Genetic Susceptibility, Mendelian Randomization, and Nomogram Model Construction of Gestational Diabetes Mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liang Q,
|
||
Li M,
|
||
Huang G,
|
||
Li R,
|
||
Qin L,
|
||
Zhong P,
|
||
Xing X,
|
||
Yu X</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2024 Oct 15;109(11):2802-2814.
|
||
doi: 10.1210/clinem/dgae200.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38625888" target="_blank">38625888</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24637646">Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao Q,
|
||
Xiao J,
|
||
He J,
|
||
Zhang X,
|
||
Hong J,
|
||
Kong X,
|
||
Mills KT,
|
||
Weng J,
|
||
Jia W,
|
||
Yang W</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2014;9(3):e91790.
|
||
Epub 2014 Mar 17
|
||
doi: 10.1371/journal.pone.0091790.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24637646" target="_blank">24637646</a><a href="/pmc/articles/PMC3956742" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22294616">Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang Z,
|
||
Rowlan JS,
|
||
Wang Q,
|
||
Shi W</span><br />
|
||
<span class="medgenPMjournal">Circ Cardiovasc Genet</span>
|
||
2012 Apr 1;5(2):190-201.
|
||
Epub 2012 Jan 31
|
||
doi: 10.1161/CIRCGENETICS.111.961649.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22294616" target="_blank">22294616</a><a href="/pmc/articles/PMC3329596" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19670153">Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schleinitz D,
|
||
Tönjes A,
|
||
Böttcher Y,
|
||
Dietrich K,
|
||
Enigk B,
|
||
Koriath M,
|
||
Scholz GH,
|
||
Blüher M,
|
||
Zeggini E,
|
||
McCarthy MI,
|
||
Kovacs P,
|
||
Stumvoll M</span><br />
|
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<span class="medgenPMjournal">Horm Metab Res</span>
|
||
2010 Jan;42(1):14-22.
|
||
Epub 2009 Aug 10
|
||
doi: 10.1055/s-0029-1233480.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19670153" target="_blank">19670153</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18678614">Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Orho-Melander M,
|
||
Melander O,
|
||
Guiducci C,
|
||
Perez-Martinez P,
|
||
Corella D,
|
||
Roos C,
|
||
Tewhey R,
|
||
Rieder MJ,
|
||
Hall J,
|
||
Abecasis G,
|
||
Tai ES,
|
||
Welch C,
|
||
Arnett DK,
|
||
Lyssenko V,
|
||
Lindholm E,
|
||
Saxena R,
|
||
de Bakker PI,
|
||
Burtt N,
|
||
Voight BF,
|
||
Hirschhorn JN,
|
||
Tucker KL,
|
||
Hedner T,
|
||
Tuomi T,
|
||
Isomaa B,
|
||
Eriksson KF,
|
||
Taskinen MR,
|
||
Wahlstrand B,
|
||
Hughes TE,
|
||
Parnell LD,
|
||
Lai CQ,
|
||
Berglund G,
|
||
Peltonen L,
|
||
Vartiainen E,
|
||
Jousilahti P,
|
||
Havulinna AS,
|
||
Salomaa V,
|
||
Nilsson P,
|
||
Groop L,
|
||
Altshuler D,
|
||
Ordovas JM,
|
||
Kathiresan S</span><br />
|
||
<span class="medgenPMjournal">Diabetes</span>
|
||
2008 Nov;57(11):3112-21.
|
||
Epub 2008 Aug 4
|
||
doi: 10.2337/db08-0516.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18678614" target="_blank">18678614</a><a href="/pmc/articles/PMC2570409" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fasting%20plasma%20glucose%20level%20quantitative%20trait%20locus%201%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (14)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34887471">miR1908-5p regulates energy homeostasis in hepatocyte models.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Soubeyrand S,
|
||
Lau P,
|
||
Beehler K,
|
||
McShane K,
|
||
McPherson R</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2021 Dec 9;11(1):23748.
|
||
doi: 10.1038/s41598-021-03156-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34887471" target="_blank">34887471</a><a href="/pmc/articles/PMC8660805" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29915365">Metabolic effects of genetic variation in the human REPIN1 gene.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krüger J,
|
||
Berger C,
|
||
Weidle K,
|
||
Schleinitz D,
|
||
Tönjes A,
|
||
Stumvoll M,
|
||
Blüher M,
|
||
Kovacs P,
|
||
Klöting N</span><br />
|
||
<span class="medgenPMjournal">Int J Obes (Lond)</span>
|
||
2019 Apr;43(4):821-831.
|
||
Epub 2018 Jun 18
|
||
doi: 10.1038/s41366-018-0123-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29915365" target="_blank">29915365</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21249489">The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grarup N,
|
||
Overvad M,
|
||
Sparsø T,
|
||
Witte DR,
|
||
Pisinger C,
|
||
Jørgensen T,
|
||
Yamauchi T,
|
||
Hara K,
|
||
Maeda S,
|
||
Kadowaki T,
|
||
Hansen T,
|
||
Pedersen O</span><br />
|
||
<span class="medgenPMjournal">Diabetologia</span>
|
||
2011 Apr;54(4):789-94.
|
||
Epub 2011 Jan 20
|
||
doi: 10.1007/s00125-010-2031-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21249489" target="_blank">21249489</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19053027">Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nordman S,
|
||
Ostenson CG,
|
||
Efendic S,
|
||
Gu HF</span><br />
|
||
<span class="medgenPMjournal">Exp Clin Endocrinol Diabetes</span>
|
||
2009 Apr;117(4):186-90.
|
||
Epub 2008 Dec 3
|
||
doi: 10.1055/s-0028-1100419.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19053027" target="_blank">19053027</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fasting%20plasma%20glucose%20level%20quantitative%20trait%20locus%201%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39418314">Evaluating the Causal Effect of Circulating Proteome on Glycemic Traits: Evidence From Mendelian Randomization.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xing X,
|
||
Xu S,
|
||
Wang Y,
|
||
Shen Z,
|
||
Wen S,
|
||
Zhang Y,
|
||
Ruan G,
|
||
Cai G</span><br />
|
||
<span class="medgenPMjournal">Diabetes</span>
|
||
2025 Jan 1;74(1):108-119.
|
||
doi: 10.2337/db24-0262.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39418314" target="_blank">39418314</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38625888">Genetic Susceptibility, Mendelian Randomization, and Nomogram Model Construction of Gestational Diabetes Mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liang Q,
|
||
Li M,
|
||
Huang G,
|
||
Li R,
|
||
Qin L,
|
||
Zhong P,
|
||
Xing X,
|
||
Yu X</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2024 Oct 15;109(11):2802-2814.
|
||
doi: 10.1210/clinem/dgae200.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38625888" target="_blank">38625888</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30715214">Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of cardiometabolic phenotypes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nikpay M,
|
||
Beehler K,
|
||
Valsesia A,
|
||
Hager J,
|
||
Harper ME,
|
||
Dent R,
|
||
McPherson R</span><br />
|
||
<span class="medgenPMjournal">Cardiovasc Res</span>
|
||
2019 Sep 1;115(11):1629-1645.
|
||
doi: 10.1093/cvr/cvz030.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30715214" target="_blank">30715214</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21249489">The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grarup N,
|
||
Overvad M,
|
||
Sparsø T,
|
||
Witte DR,
|
||
Pisinger C,
|
||
Jørgensen T,
|
||
Yamauchi T,
|
||
Hara K,
|
||
Maeda S,
|
||
Kadowaki T,
|
||
Hansen T,
|
||
Pedersen O</span><br />
|
||
<span class="medgenPMjournal">Diabetologia</span>
|
||
2011 Apr;54(4):789-94.
|
||
Epub 2011 Jan 20
|
||
doi: 10.1007/s00125-010-2031-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21249489" target="_blank">21249489</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fasting%20plasma%20glucose%20level%20quantitative%20trait%20locus%201%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38625888">Genetic Susceptibility, Mendelian Randomization, and Nomogram Model Construction of Gestational Diabetes Mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liang Q,
|
||
Li M,
|
||
Huang G,
|
||
Li R,
|
||
Qin L,
|
||
Zhong P,
|
||
Xing X,
|
||
Yu X</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2024 Oct 15;109(11):2802-2814.
|
||
doi: 10.1210/clinem/dgae200.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38625888" target="_blank">38625888</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28219716">Genetic regulation of differentially methylated genes in visceral adipose tissue of severely obese men discordant for the metabolic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guénard F,
|
||
Tchernof A,
|
||
Deshaies Y,
|
||
Biron S,
|
||
Lescelleur O,
|
||
Biertho L,
|
||
Marceau S,
|
||
Pérusse L,
|
||
Vohl MC</span><br />
|
||
<span class="medgenPMjournal">Transl Res</span>
|
||
2017 Jun;184:1-11.e2.
|
||
Epub 2017 Feb 2
|
||
doi: 10.1016/j.trsl.2017.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28219716" target="_blank">28219716</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24637646">Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao Q,
|
||
Xiao J,
|
||
He J,
|
||
Zhang X,
|
||
Hong J,
|
||
Kong X,
|
||
Mills KT,
|
||
Weng J,
|
||
Jia W,
|
||
Yang W</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2014;9(3):e91790.
|
||
Epub 2014 Mar 17
|
||
doi: 10.1371/journal.pone.0091790.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24637646" target="_blank">24637646</a><a href="/pmc/articles/PMC3956742" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18776141">Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hivert MF,
|
||
Manning AK,
|
||
McAteer JB,
|
||
Florez JC,
|
||
Dupuis J,
|
||
Fox CS,
|
||
O'Donnell CJ,
|
||
Cupples LA,
|
||
Meigs JB</span><br />
|
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<span class="medgenPMjournal">Diabetes</span>
|
||
2008 Dec;57(12):3353-9.
|
||
Epub 2008 Sep 5
|
||
doi: 10.2337/db08-0700.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18776141" target="_blank">18776141</a><a href="/pmc/articles/PMC2584143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fasting%20plasma%20glucose%20level%20quantitative%20trait%20locus%201%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38625888">Genetic Susceptibility, Mendelian Randomization, and Nomogram Model Construction of Gestational Diabetes Mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liang Q,
|
||
Li M,
|
||
Huang G,
|
||
Li R,
|
||
Qin L,
|
||
Zhong P,
|
||
Xing X,
|
||
Yu X</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2024 Oct 15;109(11):2802-2814.
|
||
doi: 10.1210/clinem/dgae200.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38625888" target="_blank">38625888</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28219716">Genetic regulation of differentially methylated genes in visceral adipose tissue of severely obese men discordant for the metabolic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guénard F,
|
||
Tchernof A,
|
||
Deshaies Y,
|
||
Biron S,
|
||
Lescelleur O,
|
||
Biertho L,
|
||
Marceau S,
|
||
Pérusse L,
|
||
Vohl MC</span><br />
|
||
<span class="medgenPMjournal">Transl Res</span>
|
||
2017 Jun;184:1-11.e2.
|
||
Epub 2017 Feb 2
|
||
doi: 10.1016/j.trsl.2017.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28219716" target="_blank">28219716</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24637646">Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao Q,
|
||
Xiao J,
|
||
He J,
|
||
Zhang X,
|
||
Hong J,
|
||
Kong X,
|
||
Mills KT,
|
||
Weng J,
|
||
Jia W,
|
||
Yang W</span><br />
|
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<span class="medgenPMjournal">PLoS One</span>
|
||
2014;9(3):e91790.
|
||
Epub 2014 Mar 17
|
||
doi: 10.1371/journal.pone.0091790.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24637646" target="_blank">24637646</a><a href="/pmc/articles/PMC3956742" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20356931">Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Burgdorf KS,
|
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Sandholt CH,
|
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Sparsø T,
|
||
Andersen G,
|
||
Witte DR,
|
||
Jørgensen T,
|
||
Sandbaek A,
|
||
Lauritzen T,
|
||
Sørensen TI,
|
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Madsbad S,
|
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Hansen T,
|
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Pedersen O</span><br />
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<span class="medgenPMjournal">Eur J Endocrinol</span>
|
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2010 Jul;163(1):81-7.
|
||
Epub 2010 Mar 31
|
||
doi: 10.1530/EJE-10-0068.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20356931" target="_blank">20356931</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15616041">A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rich SS,
|
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Bowden DW,
|
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Haffner SM,
|
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Norris JM,
|
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Saad MF,
|
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Mitchell BD,
|
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Rotter JI,
|
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Langefeld CD,
|
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Hedrick CC,
|
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Wagenknecht LE,
|
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Bergman RN;
|
||
Insulin Resistance Atherosclerosis Study (IRAS) Family Study</span><br />
|
||
<span class="medgenPMjournal">Diabetes</span>
|
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2005 Jan;54(1):290-5.
|
||
doi: 10.2337/diabetes.54.1.290.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15616041" target="_blank">15616041</a></div>
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