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<meta name="keywords" content="C1864205, age related macular degeneration 1, age related macular degeneration type 1, age related maculopathy 1, apoe, armd1, cfhr1, cfhr3, disease or syndrome, hmcn1, macular degeneration, age-related, 1, macular degeneration, age-related, reduced risk of, macular degeneration, age-related, type 1, maculopathy, age-related, 1, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Age-related macular degeneration (ARMD) is a progressive degeneration of photoreceptors and underlying retinal pigment epithelium (RPE) cells in the macula region of the retina. It is a highly prevalent disease and a major cause of blindness in the Western world. Drusen, pale excrescences of variable size, and other deposits accumulate below the RPE on the Bruch membrane; clinical and histopathologic investigations have shown that these extracellular deposits are the hallmark of early ARMD. As ARMD advances, areas of geographic atrophy of the RPE can cause visual loss, or choroidal neovascularization can occur to cause wet, or exudative, ARMD with accompanying central visual loss (summary by De et al., 2007). Genetic Heterogeneity of Age-Related Macular Degeneration ARMD2 (153800) is associated with mutation in the ABCR gene (601691) on chromosome 1p, and ARMD3 (608895) is caused by mutation in the FBLN5 gene (604580) on chromosome 14q31. Up to 50% of the attributable risk of age-related macular degeneration (ARMD4; 610698) appears to be explained by a polymorphism in the CFH gene (134370.0008). ARMD5 (613761) and ARMD6 (613757) are associated with mutation in the ERCC6 (609413) and RAX2 (610362) genes, respectively. ARMD7 (610149) and ARMD8 (613778), which both represent susceptibility linked to chromosome 10q26, are associated with single-nucleotide polymorphisms in the HTRA1 (602194) and ARMS2 (611313) genes, respectively. ARMD9 (611378) is associated with single-nucleotide polymorphisms in the C3 gene (120700). ARMD10 (611488) maps to chromosome 9q32 and may be associated with a polymorphism in the TLR4 gene (603030). ARMD11 (611953) is association with variation in the CST3 gene (604312); ARMD12 (613784) with variation in the CX3CR1 gene (601470); and ARMD13 (615439) with variation in the CFI gene (217030). ARMD14 (615489) is associated with variation in or near the C2 (613927) and CFB (138470) genes on chromosome 6p21. ARMD15 (615591) is associated with variation in the C9 gene (120940). There is evidence for a form of ARMD caused by mutation in the mitochondrial gene MTTL1 (590050). A haplotype carrying deletion of the complement factor H-related genes CFHR1 (134371) and CFHR3 (605336) is also associated with reduced risk of ARMD. Lotery and Trump (2007) reviewed the molecular biology of age-related macular degeneration and tabulated the genes associated with ARMD, including those with only positive findings versus genes for which conflicting results have been found." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=400475
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ConceptID=C1864205
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Age related macular degeneration 1<span class="h1sub">(ARMD1)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>400475</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1864205</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>MACULOPATHY, AGE-RELATED, 1</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="APOE - ID: 348 - NCBI Gene" href="/gene/348" class="medgenPMinfo">APOE</a> (19q13.32); <a target="_blank" title="CFHR1 - ID: 3078 - NCBI Gene" href="/gene/3078" class="medgenPMinfo">CFHR1</a> (1q31.3); <a target="_blank" title="CFHR3 - ID: 10878 - NCBI Gene" href="/gene/10878" class="medgenPMinfo">CFHR3</a> (1q31.3); <a target="_blank" title="HMCN1 - ID: 83872 - NCBI Gene" href="/gene/83872" class="medgenPMinfo">HMCN1</a> (1q25.3-31.1)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0011285" target="_blank">MONDO:0011285</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/603075" target="_blank">603075</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Age-related macular degeneration (ARMD) is a progressive degeneration of photoreceptors and underlying retinal pigment epithelium (RPE) cells in the macula region of the retina. It is a highly prevalent disease and a major cause of blindness in the Western world. Drusen, pale excrescences of variable size, and other deposits accumulate below the RPE on the Bruch membrane; clinical and histopathologic investigations have shown that these extracellular deposits are the hallmark of early ARMD. As ARMD advances, areas of geographic atrophy of the RPE can cause visual loss, or choroidal neovascularization can occur to cause wet, or exudative, ARMD with accompanying central visual loss (summary by De et al., 2007). Genetic Heterogeneity of Age-Related Macular Degeneration ARMD2 (153800) is associated with mutation in the ABCR gene (601691) on chromosome 1p, and ARMD3 (608895) is caused by mutation in the FBLN5 gene (604580) on chromosome 14q31. Up to 50% of the attributable risk of age-related macular degeneration (ARMD4; 610698) appears to be explained by a polymorphism in the CFH gene (134370.0008). ARMD5 (613761) and ARMD6 (613757) are associated with mutation in the ERCC6 (609413) and RAX2 (610362) genes, respectively. ARMD7 (610149) and ARMD8 (613778), which both represent susceptibility linked to chromosome 10q26, are associated with single-nucleotide polymorphisms in the HTRA1 (602194) and ARMS2 (611313) genes, respectively. ARMD9 (611378) is associated with single-nucleotide polymorphisms in the C3 gene (120700). ARMD10 (611488) maps to chromosome 9q32 and may be associated with a polymorphism in the TLR4 gene (603030). ARMD11 (611953) is association with variation in the CST3 gene (604312); ARMD12 (613784) with variation in the CX3CR1 gene (601470); and ARMD13 (615439) with variation in the CFI gene (217030). ARMD14 (615489) is associated with variation in or near the C2 (613927) and CFB (138470) genes on chromosome 6p21. ARMD15 (615591) is associated with variation in the C9 gene (120940). There is evidence for a form of ARMD caused by mutation in the mitochondrial gene MTTL1 (590050). A haplotype carrying deletion of the complement factor H-related genes CFHR1 (134371) and CFHR3 (605336) is also associated with reduced risk of ARMD. Lotery and Trump (2007) reviewed the molecular biology of age-related macular degeneration and tabulated the genes associated with ARMD, including those with only positive findings versus genes for which conflicting results have been found. [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
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||
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||
<div class="portlet mgSection" id="ID_117">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />In 10 to 15 percent of affected individuals, the dry form progresses to the wet form of age-related macular degeneration. The wet form is characterized by the growth of abnormal, fragile blood vessels underneath the macula. These vessels leak blood and fluid, which damages the macula and makes central vision appear blurry and distorted. The wet form of age-related macular degeneration is associated with severe vision loss that can worsen rapidly.<br /><br />Researchers have described two major types of age-related macular degeneration, known as the dry form and the wet form. The dry form is much more common, accounting for 85 to 90 percent of all cases of age-related macular degeneration. It is characterized by a buildup of yellowish deposits called drusen beneath the retina and vision loss that worsens slowly over time. The most advanced stage of dry age-related macular degeneration is known as geographic atrophy, in which areas of the macula waste away (atrophy), resulting in severe vision loss. Dry age-related macular degeneration typically affects vision in both eyes, although vision loss often occurs in one eye before the other.<br /><br />Age-related macular degeneration mainly affects central vision, which is needed for detailed tasks such as reading, driving, and recognizing faces. The vision loss in this condition results from a gradual deterioration of light-sensing cells in the tissue at the back of the eye that detects light and color (the retina). Specifically, age-related macular degeneration affects a small area near the center of the retina, called the macula, which is responsible for central vision. Side (peripheral) vision and night vision are generally not affected, but slow adjustment of vision to darkness (dark adaptation) and reduced dim light (scotopic) vision often occur in the early stages of the disease.<br /><br />Age-related macular degeneration is an eye disease that is a leading cause of vision loss in older people in developed countries. Subtle abnormalities indicating changes in vision may occur in a person's forties or fifties. Distorted vision and vision loss usually become noticeable in a person's sixties or seventies and tend to worsen over time. <a target="_blank" href="https://medlineplus.gov/genetics/condition/age-related-macular-degeneration">https://medlineplus.gov/genetics/condition/age-related-macular-degeneration</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_7434"><div><strong>Macular degeneration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7434</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0024437</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells of the macula lutea.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/7434">Feature record</a> | <a href="/medgen?term=%22Macular%20degeneration%22%5BClinical%20Features%5D%20OR%207434%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_154726"><div><strong>Choroidal neovascularization</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>154726</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0600518</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Choroidal neovascularization (CNV) is the creation of new blood vessels in the choroid layer of the eye.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/154726">Feature record</a> | <a href="/medgen?term=%22Choroidal%20neovascularization%22%5BClinical%20Features%5D%20OR%20154726%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_671266"><div><strong>Macular drusen</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>671266</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0677628</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in Bruch's membrane of the eye. This class refers to the presence of Drusen in the macula.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/671266">Feature record</a> | <a href="/medgen?term=%22Macular%20drusen%22%5BClinical%20Features%5D%20OR%20671266%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_323488"><div><strong>Geographic atrophy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>323488</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1536085</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sharply demarcated area of partial or complete depigmentation of the fundus reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss. The margins of the de-pigmented area are usually scalloped and the large choroidal vessels are visible through the atrophic retinal pigment epithelium.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/323488">Feature record</a> | <a href="/medgen?term=%22Geographic%20atrophy%22%5BClinical%20Features%5D%20OR%20323488%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_326867"><div><strong>Progressive visual loss</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>326867</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839364</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A reduction of previously attained ability to see.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/326867">Feature record</a> | <a href="/medgen?term=%22Progressive%20visual%20loss%22%5BClinical%20Features%5D%20OR%20326867%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1630962"><div><strong>Macular hemorrhage</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1630962</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2187053</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bleeding occurring within the macula lutea of the retina.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1630962">Feature record</a> | <a href="/medgen?term=%22Macular%20hemorrhage%22%5BClinical%20Features%5D%20OR%201630962%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_868413"><div><strong>Foveal hypopigmentation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868413</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4022807</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Decreased amount of pigmentation in the fovea centralis.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/868413">Feature record</a> | <a href="/medgen?term=%22Foveal%20hypopigmentation%22%5BClinical%20Features%5D%20OR%20868413%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the eye</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_154726" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Choroidal neovascularization</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_868413" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Foveal hypopigmentation</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_323488" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Geographic atrophy</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_7434" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Macular degeneration</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_671266" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Macular drusen</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1630962" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Macular hemorrhage</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_326867" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Progressive visual loss</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0242383[DISCUI]&test_type=Clinical" ref="ncbi_uid=116576">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=116576" target="_blank" href="/omim/590050">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=116576" ref="ncbi_uid=116576">V</a></span></span><span class="TLline"><a href="/medgen/116576" ref="tree=GTR&ncbi_uid=116576&link_uid=116576" title="View MedGen record for 'Age-related macular degeneration'">Age-related macular degeneration</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1864205[DISCUI]&test_type=Clinical" ref="ncbi_uid=400475">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=400475" target="_blank" href="/omim/603075">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=400475" ref="ncbi_uid=400475">V</a></span></span><span class="TLline">Age related macular degeneration 1</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3495438[DISCUI]&test_type=Clinical" ref="ncbi_uid=501183">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=501183" target="_blank" href="/omim/153800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=501183" ref="ncbi_uid=501183">V</a></span></span><span class="TLline"><a href="/medgen/501183" ref="tree=GTR&ncbi_uid=501183&link_uid=501183" title="View MedGen record for 'Age related macular degeneration 2'">Age related macular degeneration 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1853147[DISCUI]&test_type=Clinical" ref="ncbi_uid=339914">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=339914" target="_blank" href="/omim/610698">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=339914" ref="ncbi_uid=339914">V</a></span></span><span class="TLline"><a href="/medgen/339914" ref="tree=GTR&ncbi_uid=339914&link_uid=339914" title="View MedGen record for 'Age related macular degeneration 4'">Age related macular degeneration 4</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151063[DISCUI]&test_type=Clinical" ref="ncbi_uid=462413">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462413" target="_blank" href="/omim/613761">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462413" ref="ncbi_uid=462413">V</a></span></span><span class="TLline"><a href="/medgen/462413" ref="tree=GTR&ncbi_uid=462413&link_uid=462413" title="View MedGen record for 'Age related macular degeneration 5'">Age related macular degeneration 5</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151060[DISCUI]&test_type=Clinical" ref="ncbi_uid=462410">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462410" target="_blank" href="/omim/610362">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462410" ref="ncbi_uid=462410">V</a></span></span><span class="TLline"><a href="/medgen/462410" ref="tree=GTR&ncbi_uid=462410&link_uid=462410" title="View MedGen record for 'Age related macular degeneration 6'">Age related macular degeneration 6</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1857813[DISCUI]&test_type=Clinical" ref="ncbi_uid=347554">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=347554" target="_blank" href="/omim/610149">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=347554" ref="ncbi_uid=347554">V</a></span></span><span class="TLline"><a href="/medgen/347554" ref="tree=GTR&ncbi_uid=347554&link_uid=347554" title="View MedGen record for 'Age related macular degeneration 7'">Age related macular degeneration 7</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151070[DISCUI]&test_type=Clinical" ref="ncbi_uid=462420">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462420" target="_blank" href="/omim/613778">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462420" ref="ncbi_uid=462420">V</a></span></span><span class="TLline"><a href="/medgen/462420" ref="tree=GTR&ncbi_uid=462420&link_uid=462420" title="View MedGen record for 'Age related macular degeneration 8'">Age related macular degeneration 8</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1969651[DISCUI]&test_type=Clinical" ref="ncbi_uid=370717">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=370717" target="_blank" href="/omim/611378">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=370717" ref="ncbi_uid=370717">V</a></span></span><span class="TLline"><a href="/medgen/370717" ref="tree=GTR&ncbi_uid=370717&link_uid=370717" title="View MedGen record for 'Age related macular degeneration 9'">Age related macular degeneration 9</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1969108[DISCUI]&test_type=Clinical" ref="ncbi_uid=409758">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=409758" target="_blank" href="/omim/611488">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/409758" ref="tree=GTR&ncbi_uid=409758&link_uid=409758" title="View MedGen record for 'Age related macular degeneration 10'">Age related macular degeneration 10</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2677774[DISCUI]&test_type=Clinical" ref="ncbi_uid=393833">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=393833" target="_blank" href="/omim/604312">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=393833" ref="ncbi_uid=393833">V</a></span></span><span class="TLline"><a href="/medgen/393833" ref="tree=GTR&ncbi_uid=393833&link_uid=393833" title="View MedGen record for 'Age related macular degeneration 11'">Age related macular degeneration 11</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151079[DISCUI]&test_type=Clinical" ref="ncbi_uid=462429">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462429" target="_blank" href="/omim/613784">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462429" ref="ncbi_uid=462429">V</a></span></span><span class="TLline"><a href="/medgen/462429" ref="tree=GTR&ncbi_uid=462429&link_uid=462429" title="View MedGen record for 'Age related macular degeneration 12'">Age related macular degeneration 12</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3809523[DISCUI]&test_type=Clinical" ref="ncbi_uid=815853">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=815853" target="_blank" href="/omim/615439">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=815853" ref="ncbi_uid=815853">V</a></span></span><span class="TLline"><a href="/medgen/815853" ref="tree=GTR&ncbi_uid=815853&link_uid=815853" title="View MedGen record for 'Age related macular degeneration 13'">Age related macular degeneration 13</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3809653[DISCUI]&test_type=Clinical" ref="ncbi_uid=815983">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=815983" target="_blank" href="/omim/615489">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=815983" ref="ncbi_uid=815983">V</a></span></span><span class="TLline"><a href="/medgen/815983" ref="tree=GTR&ncbi_uid=815983&link_uid=815983" title="View MedGen record for 'Age related macular degeneration 14'">Age related macular degeneration 14</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3810042[DISCUI]&test_type=Clinical" ref="ncbi_uid=816372">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=816372" target="_blank" href="/omim/615591">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=816372" ref="ncbi_uid=816372">V</a></span></span><span class="TLline"><a href="/medgen/816372" ref="tree=GTR&ncbi_uid=816372&link_uid=816372" title="View MedGen record for 'Age related macular degeneration 15'">Age related macular degeneration 15</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1837187[DISCUI]&test_type=Clinical" ref="ncbi_uid=373276">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=373276" target="_blank" href="/omim/604580">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=373276" ref="ncbi_uid=373276">V</a></span></span><span class="TLline"><a href="/medgen/373276" ref="tree=GTR&ncbi_uid=373276&link_uid=373276" title="View MedGen record for 'Macular degeneration, age-related, 3'">Macular degeneration, age-related, 3</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/870893" ref="tree=MeSH" title="MedGen record for Abnormal posterior eye segment morphology">Abnormal posterior eye segment morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871316" ref="tree=MeSH" title="MedGen record for Abnormal fundus morphology">Abnormal fundus morphology</a></span><ul><li><span class="TLline"><a href="/medgen/472885" ref="tree=MeSH" title="MedGen record for Abnormal retinal morphology">Abnormal retinal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1624166" ref="tree=MeSH" title="MedGen record for Abnormal macular morphology">Abnormal macular morphology</a></span><ul><li><span class="TLline"><a href="/medgen/7434" ref="tree=MeSH" title="MedGen record for Macular degeneration">Macular degeneration</a></span><ul><li><span class="TLline"><a href="/medgen/116576" ref="tree=MeSH" title="MedGen record for Age-related macular degeneration">Age-related macular degeneration</a></span><ul><li><span class="matched_ds">Age related macular degeneration 1</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37195339">Short-term outcomes of intravitreal faricimab for treatment-naïve neovascular age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Matsumoto H,
|
||
Hoshino J,
|
||
Nakamura K,
|
||
Nagashima T,
|
||
Akiyama H</span><br />
|
||
<span class="medgenPMjournal">Graefes Arch Clin Exp Ophthalmol</span>
|
||
2023 Oct;261(10):2945-2952.
|
||
Epub 2023 May 17
|
||
doi: 10.1007/s00417-023-06116-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37195339" target="_blank">37195339</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35654115">New approaches to the treatment of Age-Related Macular Degeneration (AMD).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Csaky K,
|
||
Curcio CA,
|
||
Mullins RF,
|
||
Rosenfeld PJ,
|
||
Fujimoto J,
|
||
Rohrer B,
|
||
Ribero R,
|
||
Malek G,
|
||
Waheed N,
|
||
Guymer R,
|
||
Hageman GS,
|
||
Chen H,
|
||
Csete M</span><br />
|
||
<span class="medgenPMjournal">Exp Eye Res</span>
|
||
2022 Aug;221:109134.
|
||
Epub 2022 May 30
|
||
doi: 10.1016/j.exer.2022.109134.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35654115" target="_blank">35654115</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35120629">Personalized genetic counseling for Stargardt disease: Offspring risk estimates based on variant severity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cornelis SS,
|
||
Runhart EH,
|
||
Bauwens M,
|
||
Corradi Z,
|
||
De Baere E,
|
||
Roosing S,
|
||
Haer-Wigman L,
|
||
Dhaenens CM,
|
||
Vulto-van Silfhout AT,
|
||
Cremers FPM</span><br />
|
||
<span class="medgenPMjournal">Am J Hum Genet</span>
|
||
2022 Mar 3;109(3):498-507.
|
||
Epub 2022 Feb 3
|
||
doi: 10.1016/j.ajhg.2022.01.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35120629" target="_blank">35120629</a><a href="/pmc/articles/PMC8948157" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(age%20related%20macular%20degeneration%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1455)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37972955">LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera Valeda Light Delivery System.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boyer D,
|
||
Hu A,
|
||
Warrow D,
|
||
Xavier S,
|
||
Gonzalez V,
|
||
Lad E,
|
||
Rosen RB,
|
||
Do D,
|
||
Schneiderman T,
|
||
Ho A,
|
||
Munk MR,
|
||
Jaffe G,
|
||
Tedford SE,
|
||
Croissant CL,
|
||
Walker M,
|
||
Rückert R,
|
||
Tedford CE</span><br />
|
||
<span class="medgenPMjournal">Retina</span>
|
||
2024 Mar 1;44(3):487-497.
|
||
doi: 10.1097/IAE.0000000000003980.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37972955" target="_blank">37972955</a><a href="/pmc/articles/PMC10885856" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34572131">Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nashine S</span><br />
|
||
<span class="medgenPMjournal">Cells</span>
|
||
2021 Sep 19;10(9)
|
||
doi: 10.3390/cells10092483.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34572131" target="_blank">34572131</a><a href="/pmc/articles/PMC8464988" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33958600">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fleckenstein M,
|
||
Keenan TDL,
|
||
Guymer RH,
|
||
Chakravarthy U,
|
||
Schmitz-Valckenberg S,
|
||
Klaver CC,
|
||
Wong WT,
|
||
Chew EY</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2021 May 6;7(1):31.
|
||
doi: 10.1038/s41572-021-00265-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33958600" target="_blank">33958600</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33847996">Age-Related Macular Degeneration: Epidemiology and Clinical Aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Keenan TDL,
|
||
Cukras CA,
|
||
Chew EY</span><br />
|
||
<span class="medgenPMjournal">Adv Exp Med Biol</span>
|
||
2021;1256:1-31.
|
||
doi: 10.1007/978-3-030-66014-7_1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33847996" target="_blank">33847996</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23332590">Clinical classification of age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferris FL 3rd,
|
||
Wilkinson CP,
|
||
Bird A,
|
||
Chakravarthy U,
|
||
Chew E,
|
||
Csaky K,
|
||
Sadda SR;
|
||
Beckman Initiative for Macular Research Classification Committee</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2013 Apr;120(4):844-51.
|
||
Epub 2013 Jan 16
|
||
doi: 10.1016/j.ophtha.2012.10.036.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23332590" target="_blank">23332590</a><a href="/pmc/articles/PMC11551519" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age%20related%20macular%20degeneration%201%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (11395)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37972955">LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera Valeda Light Delivery System.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boyer D,
|
||
Hu A,
|
||
Warrow D,
|
||
Xavier S,
|
||
Gonzalez V,
|
||
Lad E,
|
||
Rosen RB,
|
||
Do D,
|
||
Schneiderman T,
|
||
Ho A,
|
||
Munk MR,
|
||
Jaffe G,
|
||
Tedford SE,
|
||
Croissant CL,
|
||
Walker M,
|
||
Rückert R,
|
||
Tedford CE</span><br />
|
||
<span class="medgenPMjournal">Retina</span>
|
||
2024 Mar 1;44(3):487-497.
|
||
doi: 10.1097/IAE.0000000000003980.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37972955" target="_blank">37972955</a><a href="/pmc/articles/PMC10885856" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33958600">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fleckenstein M,
|
||
Keenan TDL,
|
||
Guymer RH,
|
||
Chakravarthy U,
|
||
Schmitz-Valckenberg S,
|
||
Klaver CC,
|
||
Wong WT,
|
||
Chew EY</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2021 May 6;7(1):31.
|
||
doi: 10.1038/s41572-021-00265-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33958600" target="_blank">33958600</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33847996">Age-Related Macular Degeneration: Epidemiology and Clinical Aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Keenan TDL,
|
||
Cukras CA,
|
||
Chew EY</span><br />
|
||
<span class="medgenPMjournal">Adv Exp Med Biol</span>
|
||
2021;1256:1-31.
|
||
doi: 10.1007/978-3-030-66014-7_1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33847996" target="_blank">33847996</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29110945">The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fleckenstein M,
|
||
Mitchell P,
|
||
Freund KB,
|
||
Sadda S,
|
||
Holz FG,
|
||
Brittain C,
|
||
Henry EC,
|
||
Ferrara D</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2018 Mar;125(3):369-390.
|
||
Epub 2017 Oct 27
|
||
doi: 10.1016/j.ophtha.2017.08.038.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29110945" target="_blank">29110945</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23332590">Clinical classification of age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferris FL 3rd,
|
||
Wilkinson CP,
|
||
Bird A,
|
||
Chakravarthy U,
|
||
Chew E,
|
||
Csaky K,
|
||
Sadda SR;
|
||
Beckman Initiative for Macular Research Classification Committee</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2013 Apr;120(4):844-51.
|
||
Epub 2013 Jan 16
|
||
doi: 10.1016/j.ophtha.2012.10.036.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23332590" target="_blank">23332590</a><a href="/pmc/articles/PMC11551519" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age%20related%20macular%20degeneration%201%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7815)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38019527">Metformin Use and Age-Related Macular Degeneration in Patients Without Diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aggarwal S,
|
||
Moir J,
|
||
Hyman MJ,
|
||
Kaufmann GT,
|
||
Flores A,
|
||
Hariprasad SM,
|
||
Skondra D</span><br />
|
||
<span class="medgenPMjournal">JAMA Ophthalmol</span>
|
||
2024 Jan 1;142(1):53-57.
|
||
doi: 10.1001/jamaophthalmol.2023.5478.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38019527" target="_blank">38019527</a><a href="/pmc/articles/PMC10690576" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37972955">LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera Valeda Light Delivery System.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boyer D,
|
||
Hu A,
|
||
Warrow D,
|
||
Xavier S,
|
||
Gonzalez V,
|
||
Lad E,
|
||
Rosen RB,
|
||
Do D,
|
||
Schneiderman T,
|
||
Ho A,
|
||
Munk MR,
|
||
Jaffe G,
|
||
Tedford SE,
|
||
Croissant CL,
|
||
Walker M,
|
||
Rückert R,
|
||
Tedford CE</span><br />
|
||
<span class="medgenPMjournal">Retina</span>
|
||
2024 Mar 1;44(3):487-497.
|
||
doi: 10.1097/IAE.0000000000003980.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37972955" target="_blank">37972955</a><a href="/pmc/articles/PMC10885856" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35653117">Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chew EY,
|
||
Clemons TE,
|
||
Agrón E,
|
||
Domalpally A,
|
||
Keenan TDL,
|
||
Vitale S,
|
||
Weber C,
|
||
Smith DC,
|
||
Christen W;
|
||
AREDS2 Research Group</span><br />
|
||
<span class="medgenPMjournal">JAMA Ophthalmol</span>
|
||
2022 Jul 1;140(7):692-698.
|
||
doi: 10.1001/jamaophthalmol.2022.1640.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35653117" target="_blank">35653117</a><a href="/pmc/articles/PMC9164119" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34572131">Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nashine S</span><br />
|
||
<span class="medgenPMjournal">Cells</span>
|
||
2021 Sep 19;10(9)
|
||
doi: 10.3390/cells10092483.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34572131" target="_blank">34572131</a><a href="/pmc/articles/PMC8464988" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29110945">The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fleckenstein M,
|
||
Mitchell P,
|
||
Freund KB,
|
||
Sadda S,
|
||
Holz FG,
|
||
Brittain C,
|
||
Henry EC,
|
||
Ferrara D</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2018 Mar;125(3):369-390.
|
||
Epub 2017 Oct 27
|
||
doi: 10.1016/j.ophtha.2017.08.038.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29110945" target="_blank">29110945</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age%20related%20macular%20degeneration%201%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8403)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38244172">One-year results of treat-and-extend regimen with intravitreal faricimab for treatment-naïve neovascular age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Matsumoto H,
|
||
Hoshino J,
|
||
Nakamura K,
|
||
Akiyama H</span><br />
|
||
<span class="medgenPMjournal">Jpn J Ophthalmol</span>
|
||
2024 Mar;68(2):83-90.
|
||
Epub 2024 Jan 20
|
||
doi: 10.1007/s10384-023-01040-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38244172" target="_blank">38244172</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37668741">Six-month outcomes of switching from aflibercept to faricimab in refractory cases of neovascular age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kataoka K,
|
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Itagaki K,
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Hashiya N,
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Wakugawa S,
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Tanaka K,
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Nakayama M,
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Yamamoto A,
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Mukai R,
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Honjyo J,
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Maruko I,
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Kawai M,
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Miyara Y,
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Terao N,
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Wakatsuki Y,
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Onoe H,
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Mori R,
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Koizumi H,
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Sekiryu T,
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Iida T,
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Okada AA;
|
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for Japan AMD Research Consortium (JARC)</span><br />
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<span class="medgenPMjournal">Graefes Arch Clin Exp Ophthalmol</span>
|
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2024 Jan;262(1):43-51.
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Epub 2023 Sep 5
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<span class="bold">PMID: </span><a href="/pubmed/37668741" target="_blank">37668741</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/35653117">Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Chew EY,
|
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Clemons TE,
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Agrón E,
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Domalpally A,
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Keenan TDL,
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Vitale S,
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Weber C,
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Smith DC,
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Christen W;
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AREDS2 Research Group</span><br />
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<span class="medgenPMjournal">JAMA Ophthalmol</span>
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2022 Jul 1;140(7):692-698.
|
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doi: 10.1001/jamaophthalmol.2022.1640.
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<span class="bold">PMID: </span><a href="/pubmed/35653117" target="_blank">35653117</a><a href="/pmc/articles/PMC9164119" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/33847996">Age-Related Macular Degeneration: Epidemiology and Clinical Aspects.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Keenan TDL,
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Cukras CA,
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Chew EY</span><br />
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<span class="medgenPMjournal">Adv Exp Med Biol</span>
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2021;1256:1-31.
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doi: 10.1007/978-3-030-66014-7_1.
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<span class="bold">PMID: </span><a href="/pubmed/33847996" target="_blank">33847996</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/32379287">Characterization of Drusen and Hyperreflective Foci as Biomarkers for Disease Progression in Age-Related Macular Degeneration Using Artificial Intelligence in Optical Coherence Tomography.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Waldstein SM,
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Vogl WD,
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Bogunovic H,
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Sadeghipour A,
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Riedl S,
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Schmidt-Erfurth U</span><br />
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<span class="medgenPMjournal">JAMA Ophthalmol</span>
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2020 Jul 1;138(7):740-747.
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doi: 10.1001/jamaophthalmol.2020.1376.
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<span class="bold">PMID: </span><a href="/pubmed/32379287" target="_blank">32379287</a><a href="/pmc/articles/PMC7206537" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age%20related%20macular%20degeneration%201%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5217)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/37972955">LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera Valeda Light Delivery System.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Boyer D,
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Hu A,
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Warrow D,
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Xavier S,
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Gonzalez V,
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Lad E,
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Rosen RB,
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Do D,
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Schneiderman T,
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Ho A,
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Munk MR,
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Jaffe G,
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Tedford SE,
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Croissant CL,
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Walker M,
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Rückert R,
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Tedford CE</span><br />
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<span class="medgenPMjournal">Retina</span>
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2024 Mar 1;44(3):487-497.
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doi: 10.1097/IAE.0000000000003980.
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<span class="bold">PMID: </span><a href="/pubmed/37972955" target="_blank">37972955</a><a href="/pmc/articles/PMC10885856" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/32298788">Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Kaarniranta K,
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Uusitalo H,
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Blasiak J,
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Felszeghy S,
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Kannan R,
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Kauppinen A,
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Salminen A,
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<span class="medgenPMjournal">Prog Retin Eye Res</span>
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2020 Nov;79:100858.
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Epub 2020 Apr 13
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doi: 10.1016/j.preteyeres.2020.100858.
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<span class="bold">PMID: </span><a href="/pubmed/32298788" target="_blank">32298788</a><a href="/pmc/articles/PMC7650008" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/29110945">The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fleckenstein M,
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Mitchell P,
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Freund KB,
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Sadda S,
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Holz FG,
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Brittain C,
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2018 Mar;125(3):369-390.
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<span class="bold">PMID: </span><a href="/pubmed/29110945" target="_blank">29110945</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/25104651">Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wong WL,
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Su X,
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Li X,
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Cheung CM,
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Klein R,
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Cheng CY,
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Wong TY</span><br />
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<span class="medgenPMjournal">Lancet Glob Health</span>
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2014 Feb;2(2):e106-16.
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<span class="bold">PMID: </span><a href="/pubmed/25104651" target="_blank">25104651</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/23332590">Clinical classification of age-related macular degeneration.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ferris FL 3rd,
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Wilkinson CP,
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Bird A,
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Chakravarthy U,
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Chew E,
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Csaky K,
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Sadda SR;
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<span class="medgenPMjournal">Ophthalmology</span>
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2013 Apr;120(4):844-51.
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<span class="bold">PMID: </span><a href="/pubmed/23332590" target="_blank">23332590</a><a href="/pmc/articles/PMC11551519" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age%20related%20macular%20degeneration%201%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5952)</a></div></div>
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33576772">A Global Assessment of Eye Health and Quality of Life: A Systematic Review of Systematic Reviews.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Assi L,
|
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Chamseddine F,
|
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Ibrahim P,
|
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Sabbagh H,
|
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Rosman L,
|
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Congdon N,
|
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Evans J,
|
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Ramke J,
|
||
Kuper H,
|
||
Burton MJ,
|
||
Ehrlich JR,
|
||
Swenor BK</span><br />
|
||
<span class="medgenPMjournal">JAMA Ophthalmol</span>
|
||
2021 May 1;139(5):526-541.
|
||
doi: 10.1001/jamaophthalmol.2021.0146.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33576772" target="_blank">33576772</a><a href="/pmc/articles/PMC7881366" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33275949">Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2019 Blindness and Vision Impairment Collaborators;
|
||
Vision Loss Expert Group of the Global Burden of Disease Study</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2021 Feb;9(2):e144-e160.
|
||
Epub 2020 Dec 1
|
||
doi: 10.1016/S2214-109X(20)30489-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33275949" target="_blank">33275949</a><a href="/pmc/articles/PMC7820391" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32347918">The Complications of Myopia: A Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haarman AEG,
|
||
Enthoven CA,
|
||
Tideman JWL,
|
||
Tedja MS,
|
||
Verhoeven VJM,
|
||
Klaver CCW</span><br />
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||
<span class="medgenPMjournal">Invest Ophthalmol Vis Sci</span>
|
||
2020 Apr 9;61(4):49.
|
||
doi: 10.1167/iovs.61.4.49.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32347918" target="_blank">32347918</a><a href="/pmc/articles/PMC7401976" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29032195">Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Flaxman SR,
|
||
Bourne RRA,
|
||
Resnikoff S,
|
||
Ackland P,
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||
Braithwaite T,
|
||
Cicinelli MV,
|
||
Das A,
|
||
Jonas JB,
|
||
Keeffe J,
|
||
Kempen JH,
|
||
Leasher J,
|
||
Limburg H,
|
||
Naidoo K,
|
||
Pesudovs K,
|
||
Silvester A,
|
||
Stevens GA,
|
||
Tahhan N,
|
||
Wong TY,
|
||
Taylor HR;
|
||
Vision Loss Expert Group of the Global Burden of Disease Study</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2017 Dec;5(12):e1221-e1234.
|
||
Epub 2017 Oct 11
|
||
doi: 10.1016/S2214-109X(17)30393-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29032195" target="_blank">29032195</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25104651">Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wong WL,
|
||
Su X,
|
||
Li X,
|
||
Cheung CM,
|
||
Klein R,
|
||
Cheng CY,
|
||
Wong TY</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2014 Feb;2(2):e106-16.
|
||
Epub 2014 Jan 3
|
||
doi: 10.1016/S2214-109X(13)70145-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25104651" target="_blank">25104651</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age%20related%20macular%20degeneration%201%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (406)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1864205%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (17)</a></li>
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<li><a href="/gtr/tests?term=C1864205%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (21)</a></li>
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<li><a href="/gtr/tests?term=C1864205%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1864205%5bDISCUI%5d" target="_blank">See all (26)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=107741%20134371%20605336%20608548" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=348[geneid]" target="_blank">View APOE variations in ClinVar</a></li><li><a href="/clinvar/?term=3078[geneid]" target="_blank">View CFHR1 variations in ClinVar</a></li><li><a href="/clinvar/?term=10878[geneid]" target="_blank">View CFHR3 variations in ClinVar</a></li><li><a href="/clinvar/?term=83872[geneid]" target="_blank">View HMCN1 variations in ClinVar</a></li><li><a href="/nuccore/163954918,226530554,261245112,269954687" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=603075" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<a href="/pubmed/clinical?term=Age%20related%20macular%20degeneration%201" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67cb4669f4a390645efcb3d0">C1842914[trait identifier] AND "Illumina Laboratory Services, Ill... <span class="number">(76)</span></a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67cb4668b15b832ebcc736c5">Adult-onset foveomacular vitelliform dystrophy</a>
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<div class="ralinkpop offscreen_noflow">Adult-onset foveomacular vitelliform dystrophy<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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