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<meta name="keywords" content="C1863600, capb, ephb2, finding, pcbc, prostate cancer, progression and metastasis of, somatic, prostate cancer, susceptibility to, in african americans, somatic, prostate cancer/brain cancer susceptibility, prostate cancer/brain cancer susceptibility, somatic, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Prostate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal, multiply without control or order, and form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm.\n\nEarly prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical exam called a digital rectal exam (DRE). As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.\n\nThe severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.\n\nSome cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. \n\nA small percentage of prostate cancers are hereditary and occur in families. These hereditary cancers are associated with inherited gene variants. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=400334
ConceptID=C1863600
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Prostate cancer/brain cancer susceptibility</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>400334</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C1863600</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>PROSTATE CANCER, PROGRESSION AND METASTASIS OF, SOMATIC; PROSTATE CANCER, SUSCEPTIBILITY TO, IN AFRICAN AMERICANS, SOMATIC</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="EPHB2 - ID: 2048 - NCBI Gene" href="/gene/2048" class="medgenPMinfo">EPHB2</a> (1p36.12)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0011361" target="_blank">MONDO:0011361</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/603688" target="_blank">603688</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Prostate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal, multiply without control or order, and form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm.<br /><br />Early prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical exam called a digital rectal exam (DRE). As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.<br /><br />The severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.<br /><br />Some cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. <br /><br />A small percentage of prostate cancers are hereditary and occur in families. These hereditary cancers are associated with inherited gene variants. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
</div>
<div class="portlet mgSection" id="ID_102">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_138169"><div><strong>Malignant tumor of prostate</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>138169</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0376358</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">A cancer of the prostate.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/138169">Feature record</a> | <a href="/medgen?term=%22Malignant%20tumor%20of%20prostate%22%5BClinical%20Features%5D%20OR%20138169%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_88335"><div><strong>Neoplasm of the central nervous system</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>88335</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0085136</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">A neoplasm of the central nervous system.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/88335">Feature record</a> | <a href="/medgen?term=%22Neoplasm%20of%20the%20central%20nervous%20system%22%5BClinical%20Features%5D%20OR%2088335%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_88335" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neoplasm of the central nervous system</a></span></li></ul></li><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_138169" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Malignant tumor of prostate</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/33406487">Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Daly MB,
Pal T,
Berry MP,
Buys SS,
Dickson P,
Domchek SM,
Elkhanany A,
Friedman S,
Goggins M,
Hutton ML;
CGC,
Karlan BY,
Khan S,
Klein C,
Kohlmann W;
CGC,
Kurian AW,
Laronga C,
Litton JK,
Mak JS;
LCGC,
Menendez CS,
Merajver SD,
Norquist BS,
Offit K,
Pederson HJ,
Reiser G;
CGC,
Senter-Jamieson L;
CGC,
Shannon KM,
Shatsky R,
Visvanathan K,
Weitzel JN,
Wick MJ,
Wisinski KB,
Yurgelun MB,
Darlow SD,
Dwyer MA</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2021 Jan 6;19(1):77-102.
doi: 10.6004/jnccn.2021.0001.
<span class="bold">PMID: </span><a href="/pubmed/33406487" target="_blank">33406487</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32194849">Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chandrasekharan P,
Tay ZW,
Hensley D,
Zhou XY,
Fung BK,
Colson C,
Lu Y,
Fellows BD,
Huynh Q,
Saayujya C,
Yu E,
Orendorff R,
Zheng B,
Goodwill P,
Rinaldi C,
Conolly S</span><br />
<span class="medgenPMjournal">Theranostics</span>
2020;10(7):2965-2981.
Epub 2020 Feb 10
doi: 10.7150/thno.40858.
<span class="bold">PMID: </span><a href="/pubmed/32194849" target="_blank">32194849</a><a href="/pmc/articles/PMC7053197" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9467011">Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Marsh DJ,
Coulon V,
Lunetta KL,
Rocca-Serra P,
Dahia PL,
Zheng Z,
Liaw D,
Caron S,
Duboué B,
Lin AY,
Richardson AL,
Bonnetblanc JM,
Bressieux JM,
Cabarrot-Moreau A,
Chompret A,
Demange L,
Eeles RA,
Yahanda AM,
Fearon ER,
Fricker JP,
Gorlin RJ,
Hodgson SV,
Huson S,
Lacombe D,
Eng C</span><br />
<span class="medgenPMjournal">Hum Mol Genet</span>
1998 Mar;7(3):507-15.
doi: 10.1093/hmg/7.3.507.
<span class="bold">PMID: </span><a href="/pubmed/9467011" target="_blank">9467011</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(prostate%20cancer%2Fbrain%20cancer%20susceptibility)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36788297">Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sugier PE,
Lucotte EA,
Domenighetti C,
Law MH,
Iles MM,
Brown K,
Amos C,
McKay JD,
Hung RJ,
Karimi M,
Bacq-Daian D,
Boland-Augé A,
Olaso R,
Deleuze JF,
Lesueur F,
Ostroumova E,
Kesminiene A,
de Vathaire F,
Guénel P;
EPITHYR consortium,
Sreelatha AAK,
Schulte C,
Grover S,
May P,
Bobbili DR,
Radivojkov-Blagojevic M,
Lichtner P,
Singleton AB,
Hernandez DG,
Edsall C,
Mellick GD,
Zimprich A,
Pirker W,
Rogaeva E,
Lang AE,
Koks S,
Taba P,
Lesage S,
Brice A,
Corvol JC,
Chartier-Harlin MC,
Mutez E,
Brockmann K,
Deutschländer AB,
Hadjigeorgiou GM,
Dardiotis E,
Stefanis L,
Simitsi AM,
Valente EM,
Petrucci S,
Straniero L,
Zecchinelli A,
Pezzoli G,
Brighina L,
Ferrarese C,
Annesi G,
Quattrone A,
Gagliardi M,
Matsuo H,
Nakayama A,
Hattori N,
Nishioka K,
Chung SJ,
Kim YJ,
Kolber P,
van de Warrenburg BPC,
Bloem BR,
Aasly J,
Toft M,
Pihlstrøm L,
Guedes LC,
Ferreira JJ,
Bardien S,
Carr J,
Tolosa E,
Ezquerra M,
Pastor P,
Diez-Fairen M,
Wirdefeldt K,
Pedersen N,
Ran C,
Belin AC,
Puschmann A,
Rödström EY,
Clarke CE,
Morrison KE,
Tan M,
Krainc D,
Burbulla LF,
Farrer MJ,
Kruger R,
Gasser T,
Sharma M;
Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) consortium,
Truong T,
Elbaz A</span><br />
<span class="medgenPMjournal">Mov Disord</span>
2023 Apr;38(4):604-615.
Epub 2023 Feb 14
doi: 10.1002/mds.29337.
<span class="bold">PMID: </span><a href="/pubmed/36788297" target="_blank">36788297</a><a href="/pmc/articles/PMC10334300" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33406487">Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Daly MB,
Pal T,
Berry MP,
Buys SS,
Dickson P,
Domchek SM,
Elkhanany A,
Friedman S,
Goggins M,
Hutton ML;
CGC,
Karlan BY,
Khan S,
Klein C,
Kohlmann W;
CGC,
Kurian AW,
Laronga C,
Litton JK,
Mak JS;
LCGC,
Menendez CS,
Merajver SD,
Norquist BS,
Offit K,
Pederson HJ,
Reiser G;
CGC,
Senter-Jamieson L;
CGC,
Shannon KM,
Shatsky R,
Visvanathan K,
Weitzel JN,
Wick MJ,
Wisinski KB,
Yurgelun MB,
Darlow SD,
Dwyer MA</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2021 Jan 6;19(1):77-102.
doi: 10.6004/jnccn.2021.0001.
<span class="bold">PMID: </span><a href="/pubmed/33406487" target="_blank">33406487</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32514122">Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ishigaki K,
Akiyama M,
Kanai M,
Takahashi A,
Kawakami E,
Sugishita H,
Sakaue S,
Matoba N,
Low SK,
Okada Y,
Terao C,
Amariuta T,
Gazal S,
Kochi Y,
Horikoshi M,
Suzuki K,
Ito K,
Koyama S,
Ozaki K,
Niida S,
Sakata Y,
Sakata Y,
Kohno T,
Shiraishi K,
Momozawa Y,
Hirata M,
Matsuda K,
Ikeda M,
Iwata N,
Ikegawa S,
Kou I,
Tanaka T,
Nakagawa H,
Suzuki A,
Hirota T,
Tamari M,
Chayama K,
Miki D,
Mori M,
Nagayama S,
Daigo Y,
Miki Y,
Katagiri T,
Ogawa O,
Obara W,
Ito H,
Yoshida T,
Imoto I,
Takahashi T,
Tanikawa C,
Suzuki T,
Sinozaki N,
Minami S,
Yamaguchi H,
Asai S,
Takahashi Y,
Yamaji K,
Takahashi K,
Fujioka T,
Takata R,
Yanai H,
Masumoto A,
Koretsune Y,
Kutsumi H,
Higashiyama M,
Murayama S,
Minegishi N,
Suzuki K,
Tanno K,
Shimizu A,
Yamaji T,
Iwasaki M,
Sawada N,
Uemura H,
Tanaka K,
Naito M,
Sasaki M,
Wakai K,
Tsugane S,
Yamamoto M,
Yamamoto K,
Murakami Y,
Nakamura Y,
Raychaudhuri S,
Inazawa J,
Yamauchi T,
Kadowaki T,
Kubo M,
Kamatani Y</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2020 Jul;52(7):669-679.
Epub 2020 Jun 8
doi: 10.1038/s41588-020-0640-3.
<span class="bold">PMID: </span><a href="/pubmed/32514122" target="_blank">32514122</a><a href="/pmc/articles/PMC7968075" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32340289">Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">To PK,
Do MH,
Cho JH,
Jung C</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2020 Apr 23;21(8)
doi: 10.3390/ijms21082991.
<span class="bold">PMID: </span><a href="/pubmed/32340289" target="_blank">32340289</a><a href="/pmc/articles/PMC7216164" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31337882">Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dominguez-Valentin M,
Sampson JR,
Seppälä TT,
Ten Broeke SW,
Plazzer JP,
Nakken S,
Engel C,
Aretz S,
Jenkins MA,
Sunde L,
Bernstein I,
Capella G,
Balaguer F,
Thomas H,
Evans DG,
Burn J,
Greenblatt M,
Hovig E,
de Vos Tot Nederveen Cappel WH,
Sijmons RH,
Bertario L,
Tibiletti MG,
Cavestro GM,
Lindblom A,
Della Valle A,
Lopez-Köstner F,
Gluck N,
Katz LH,
Heinimann K,
Vaccaro CA,
Büttner R,
Görgens H,
Holinski-Feder E,
Morak M,
Holzapfel S,
Hüneburg R,
Knebel Doeberitz MV,
Loeffler M,
Rahner N,
Schackert HK,
Steinke-Lange V,
Schmiegel W,
Vangala D,
Pylvänäinen K,
Renkonen-Sinisalo L,
Hopper JL,
Win AK,
Haile RW,
Lindor NM,
Gallinger S,
Le Marchand L,
Newcomb PA,
Figueiredo JC,
Thibodeau SN,
Wadt K,
Therkildsen C,
Okkels H,
Ketabi Z,
Moreira L,
Sánchez A,
Serra-Burriel M,
Pineda M,
Navarro M,
Blanco I,
Green K,
Lalloo F,
Crosbie EJ,
Hill J,
Denton OG,
Frayling IM,
Rødland EA,
Vasen H,
Mints M,
Neffa F,
Esperon P,
Alvarez K,
Kariv R,
Rosner G,
Pinero TA,
Gonzalez ML,
Kalfayan P,
Tjandra D,
Winship IM,
Macrae F,
Möslein G,
Mecklin JP,
Nielsen M,
Møller P</span><br />
<span class="medgenPMjournal">Genet Med</span>
2020 Jan;22(1):15-25.
Epub 2019 Jul 24
doi: 10.1038/s41436-019-0596-9.
<span class="bold">PMID: </span><a href="/pubmed/31337882" target="_blank">31337882</a><a href="/pmc/articles/PMC7371626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2Fbrain%20cancer%20susceptibility%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (63)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38271656">Microsatellite Instability Is Insufficiently Used as a Biomarker for Lynch Syndrome Testing in Clinical Practice.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Papadopoulou E,
Rigas G,
Fountzilas E,
Boutis A,
Giassas S,
Mitsimponas N,
Daliani D,
Ziogas DC,
Liontos M,
Ramfidis V,
Christophilakis C,
Matthaios D,
Floros T,
Florou-Chatzigiannidou C,
Agiannitopoulos K,
Meintani A,
Tsantikidi A,
Katseli A,
Potska K,
Tsaousis G,
Metaxa-Mariatou V,
Nasioulas G</span><br />
<span class="medgenPMjournal">JCO Precis Oncol</span>
2024 Jan;8:e2300332.
doi: 10.1200/PO.23.00332.
<span class="bold">PMID: </span><a href="/pubmed/38271656" target="_blank">38271656</a><a href="/pmc/articles/PMC10830089" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33406487">Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Daly MB,
Pal T,
Berry MP,
Buys SS,
Dickson P,
Domchek SM,
Elkhanany A,
Friedman S,
Goggins M,
Hutton ML;
CGC,
Karlan BY,
Khan S,
Klein C,
Kohlmann W;
CGC,
Kurian AW,
Laronga C,
Litton JK,
Mak JS;
LCGC,
Menendez CS,
Merajver SD,
Norquist BS,
Offit K,
Pederson HJ,
Reiser G;
CGC,
Senter-Jamieson L;
CGC,
Shannon KM,
Shatsky R,
Visvanathan K,
Weitzel JN,
Wick MJ,
Wisinski KB,
Yurgelun MB,
Darlow SD,
Dwyer MA</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2021 Jan 6;19(1):77-102.
doi: 10.6004/jnccn.2021.0001.
<span class="bold">PMID: </span><a href="/pubmed/33406487" target="_blank">33406487</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30847370">Longitudinal advanced MRI case report of white matter radiation necrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wiggermann V,
Lapointe E,
Litvin L,
Graf C,
Hernández-Torres E,
McKenzie M,
Vavasour IM,
Laule C,
MacMillan EL,
Li DKB,
Kolind SH,
Rauscher A,
Traboulsee AL</span><br />
<span class="medgenPMjournal">Ann Clin Transl Neurol</span>
2019 Feb;6(2):379-385.
Epub 2018 Dec 10
doi: 10.1002/acn3.704.
<span class="bold">PMID: </span><a href="/pubmed/30847370" target="_blank">30847370</a><a href="/pmc/articles/PMC6389755" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29528821">Lynch Syndrome: Genomics Update and Imaging Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cox VL,
Saeed Bamashmos AA,
Foo WC,
Gupta S,
Yedururi S,
Garg N,
Kang HC</span><br />
<span class="medgenPMjournal">Radiographics</span>
2018 Mar-Apr;38(2):483-499.
doi: 10.1148/rg.2018170075.
<span class="bold">PMID: </span><a href="/pubmed/29528821" target="_blank">29528821</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27192086">Susceptibility-weighted imaging: current status and future directions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liu S,
Buch S,
Chen Y,
Choi HS,
Dai Y,
Habib C,
Hu J,
Jung JY,
Luo Y,
Utriainen D,
Wang M,
Wu D,
Xia S,
Haacke EM</span><br />
<span class="medgenPMjournal">NMR Biomed</span>
2017 Apr;30(4)
Epub 2016 May 18
doi: 10.1002/nbm.3552.
<span class="bold">PMID: </span><a href="/pubmed/27192086" target="_blank">27192086</a><a href="/pmc/articles/PMC5116013" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2Fbrain%20cancer%20susceptibility%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (34)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/34439854">BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xavier MA,
Rezende F,
Titze-de-Almeida R,
Cornelissen B</span><br />
<span class="medgenPMjournal">Biomolecules</span>
2021 Aug 11;11(8)
doi: 10.3390/biom11081188.
<span class="bold">PMID: </span><a href="/pubmed/34439854" target="_blank">34439854</a><a href="/pmc/articles/PMC8394995" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33529725">The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ala M</span><br />
<span class="medgenPMjournal">Eur J Pharmacol</span>
2021 Apr 5;896:173921.
Epub 2021 Jan 30
doi: 10.1016/j.ejphar.2021.173921.
<span class="bold">PMID: </span><a href="/pubmed/33529725" target="_blank">33529725</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33142238">ONC201 and imipridones: Anti-cancer compounds with clinical efficacy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prabhu VV,
Morrow S,
Rahman Kawakibi A,
Zhou L,
Ralff M,
Ray J,
Jhaveri A,
Ferrarini I,
Lee Y,
Parker C,
Zhang Y,
Borsuk R,
Chang WI,
Honeyman JN,
Tavora F,
Carneiro B,
Raufi A,
Huntington K,
Carlsen L,
Louie A,
Safran H,
Seyhan AA,
Tarapore RS,
Schalop L,
Stogniew M,
Allen JE,
Oster W,
El-Deiry WS</span><br />
<span class="medgenPMjournal">Neoplasia</span>
2020 Dec;22(12):725-744.
Epub 2020 Oct 23
doi: 10.1016/j.neo.2020.09.005.
<span class="bold">PMID: </span><a href="/pubmed/33142238" target="_blank">33142238</a><a href="/pmc/articles/PMC7588802" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32340289">Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">To PK,
Do MH,
Cho JH,
Jung C</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2020 Apr 23;21(8)
doi: 10.3390/ijms21082991.
<span class="bold">PMID: </span><a href="/pubmed/32340289" target="_blank">32340289</a><a href="/pmc/articles/PMC7216164" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21600374">An update on cancer- and chemotherapy-related cognitive dysfunction: current status.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Janelsins MC,
Kohli S,
Mohile SG,
Usuki K,
Ahles TA,
Morrow GR</span><br />
<span class="medgenPMjournal">Semin Oncol</span>
2011 Jun;38(3):431-8.
doi: 10.1053/j.seminoncol.2011.03.014.
<span class="bold">PMID: </span><a href="/pubmed/21600374" target="_blank">21600374</a><a href="/pmc/articles/PMC3120018" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2Fbrain%20cancer%20susceptibility%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34439854">BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xavier MA,
Rezende F,
Titze-de-Almeida R,
Cornelissen B</span><br />
<span class="medgenPMjournal">Biomolecules</span>
2021 Aug 11;11(8)
doi: 10.3390/biom11081188.
<span class="bold">PMID: </span><a href="/pubmed/34439854" target="_blank">34439854</a><a href="/pmc/articles/PMC8394995" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33529725">The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ala M</span><br />
<span class="medgenPMjournal">Eur J Pharmacol</span>
2021 Apr 5;896:173921.
Epub 2021 Jan 30
doi: 10.1016/j.ejphar.2021.173921.
<span class="bold">PMID: </span><a href="/pubmed/33529725" target="_blank">33529725</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31337882">Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dominguez-Valentin M,
Sampson JR,
Seppälä TT,
Ten Broeke SW,
Plazzer JP,
Nakken S,
Engel C,
Aretz S,
Jenkins MA,
Sunde L,
Bernstein I,
Capella G,
Balaguer F,
Thomas H,
Evans DG,
Burn J,
Greenblatt M,
Hovig E,
de Vos Tot Nederveen Cappel WH,
Sijmons RH,
Bertario L,
Tibiletti MG,
Cavestro GM,
Lindblom A,
Della Valle A,
Lopez-Köstner F,
Gluck N,
Katz LH,
Heinimann K,
Vaccaro CA,
Büttner R,
Görgens H,
Holinski-Feder E,
Morak M,
Holzapfel S,
Hüneburg R,
Knebel Doeberitz MV,
Loeffler M,
Rahner N,
Schackert HK,
Steinke-Lange V,
Schmiegel W,
Vangala D,
Pylvänäinen K,
Renkonen-Sinisalo L,
Hopper JL,
Win AK,
Haile RW,
Lindor NM,
Gallinger S,
Le Marchand L,
Newcomb PA,
Figueiredo JC,
Thibodeau SN,
Wadt K,
Therkildsen C,
Okkels H,
Ketabi Z,
Moreira L,
Sánchez A,
Serra-Burriel M,
Pineda M,
Navarro M,
Blanco I,
Green K,
Lalloo F,
Crosbie EJ,
Hill J,
Denton OG,
Frayling IM,
Rødland EA,
Vasen H,
Mints M,
Neffa F,
Esperon P,
Alvarez K,
Kariv R,
Rosner G,
Pinero TA,
Gonzalez ML,
Kalfayan P,
Tjandra D,
Winship IM,
Macrae F,
Möslein G,
Mecklin JP,
Nielsen M,
Møller P</span><br />
<span class="medgenPMjournal">Genet Med</span>
2020 Jan;22(1):15-25.
Epub 2019 Jul 24
doi: 10.1038/s41436-019-0596-9.
<span class="bold">PMID: </span><a href="/pubmed/31337882" target="_blank">31337882</a><a href="/pmc/articles/PMC7371626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23751076">Genome variation and personalized cancer medicine.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hudson TJ</span><br />
<span class="medgenPMjournal">J Intern Med</span>
2013 Nov;274(5):440-50.
doi: 10.1111/joim.12097.
<span class="bold">PMID: </span><a href="/pubmed/23751076" target="_blank">23751076</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15184609">Stroke in patients with cancer: incidence and etiology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cestari DM,
Weine DM,
Panageas KS,
Segal AZ,
DeAngelis LM</span><br />
<span class="medgenPMjournal">Neurology</span>
2004 Jun 8;62(11):2025-30.
doi: 10.1212/01.wnl.0000129912.56486.2b.
<span class="bold">PMID: </span><a href="/pubmed/15184609" target="_blank">15184609</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2Fbrain%20cancer%20susceptibility%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (34)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/37862240">Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Naderi E,
Aguado-Barrera ME,
Schack LMH,
Dorling L,
Rattay T,
Fachal L,
Summersgill H,
Martínez-Calvo L,
Welsh C,
Dudding T,
Odding Y,
Varela-Pazos A,
Jena R,
Thomson DJ,
Steenbakkers RJHM,
Dennis J,
Lobato-Busto R,
Alsner J,
Ness A,
Nutting C,
Gómez-Caamaño A,
Eriksen JG,
Thomas SJ,
Bates AM,
Webb AJ,
Choudhury A,
Rosenstein BS,
Taboada-Valladares B,
Herskind C,
Azria D,
Dearnaley DP,
de Ruysscher D,
Sperk E,
Hall E,
Stobart H,
Chang-Claude J,
De Ruyck K,
Veldeman L,
Altabas M,
De Santis MC,
Farcy-Jacquet MP,
Veldwijk MR,
Sydes MR,
Parliament M,
Usmani N,
Burnet NG,
Seibold P,
Symonds RP,
Elliott RM,
Bultijnck R,
Gutiérrez-Enríquez S,
Mollà M,
Gulliford SL,
Green S,
Rancati T,
Reyes V,
Carballo A,
Peleteiro P,
Sosa-Fajardo P,
Parker C,
Fonteyne V,
Johnson K,
Lambrecht M,
Vanneste B,
Valdagni R,
Giraldo A,
Ramos M,
Diergaarde B,
Liu G,
Leal SM,
Chua MLK,
Pring M,
Overgaard J,
Cascallar-Caneda LM,
Duprez F,
Talbot CJ,
Barnett GC,
Dunning AM,
Vega A,
Andreassen CN,
Langendijk JA,
West CML,
Alizadeh BZ,
Kerns SL;
Radiogenomics Consortium</span><br />
<span class="medgenPMjournal">JNCI Cancer Spectr</span>
2023 Oct 31;7(6)
doi: 10.1093/jncics/pkad088.
<span class="bold">PMID: </span><a href="/pubmed/37862240" target="_blank">37862240</a><a href="/pmc/articles/PMC10653584" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36788297">Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sugier PE,
Lucotte EA,
Domenighetti C,
Law MH,
Iles MM,
Brown K,
Amos C,
McKay JD,
Hung RJ,
Karimi M,
Bacq-Daian D,
Boland-Augé A,
Olaso R,
Deleuze JF,
Lesueur F,
Ostroumova E,
Kesminiene A,
de Vathaire F,
Guénel P;
EPITHYR consortium,
Sreelatha AAK,
Schulte C,
Grover S,
May P,
Bobbili DR,
Radivojkov-Blagojevic M,
Lichtner P,
Singleton AB,
Hernandez DG,
Edsall C,
Mellick GD,
Zimprich A,
Pirker W,
Rogaeva E,
Lang AE,
Koks S,
Taba P,
Lesage S,
Brice A,
Corvol JC,
Chartier-Harlin MC,
Mutez E,
Brockmann K,
Deutschländer AB,
Hadjigeorgiou GM,
Dardiotis E,
Stefanis L,
Simitsi AM,
Valente EM,
Petrucci S,
Straniero L,
Zecchinelli A,
Pezzoli G,
Brighina L,
Ferrarese C,
Annesi G,
Quattrone A,
Gagliardi M,
Matsuo H,
Nakayama A,
Hattori N,
Nishioka K,
Chung SJ,
Kim YJ,
Kolber P,
van de Warrenburg BPC,
Bloem BR,
Aasly J,
Toft M,
Pihlstrøm L,
Guedes LC,
Ferreira JJ,
Bardien S,
Carr J,
Tolosa E,
Ezquerra M,
Pastor P,
Diez-Fairen M,
Wirdefeldt K,
Pedersen N,
Ran C,
Belin AC,
Puschmann A,
Rödström EY,
Clarke CE,
Morrison KE,
Tan M,
Krainc D,
Burbulla LF,
Farrer MJ,
Kruger R,
Gasser T,
Sharma M;
Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) consortium,
Truong T,
Elbaz A</span><br />
<span class="medgenPMjournal">Mov Disord</span>
2023 Apr;38(4):604-615.
Epub 2023 Feb 14
doi: 10.1002/mds.29337.
<span class="bold">PMID: </span><a href="/pubmed/36788297" target="_blank">36788297</a><a href="/pmc/articles/PMC10334300" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36749655">DNA Methylation Landscapes of Prostate Cancer Brain Metastasis Are Shaped by Early Driver Genetic Alterations.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gallon J,
Rodriguez-Calero A,
Benjak A,
Akhoundova D,
Maletti S,
Amstutz U,
Hewer E,
Genitsch V,
Fleischmann A,
Rushing EJ,
Grobholz R,
Fischer I,
Jochum W,
Cathomas G,
Osunkoya AO,
Bubendorf L,
Moch H,
Thalmann G,
Feng FY,
Gillessen S,
Ng CKY,
Rubin MA,
Piscuoglio S</span><br />
<span class="medgenPMjournal">Cancer Res</span>
2023 Apr 14;83(8):1203-1213.
doi: 10.1158/0008-5472.CAN-22-2236.
<span class="bold">PMID: </span><a href="/pubmed/36749655" target="_blank">36749655</a><a href="/pmc/articles/PMC10102845" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33529725">The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ala M</span><br />
<span class="medgenPMjournal">Eur J Pharmacol</span>
2021 Apr 5;896:173921.
Epub 2021 Jan 30
doi: 10.1016/j.ejphar.2021.173921.
<span class="bold">PMID: </span><a href="/pubmed/33529725" target="_blank">33529725</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31337882">Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dominguez-Valentin M,
Sampson JR,
Seppälä TT,
Ten Broeke SW,
Plazzer JP,
Nakken S,
Engel C,
Aretz S,
Jenkins MA,
Sunde L,
Bernstein I,
Capella G,
Balaguer F,
Thomas H,
Evans DG,
Burn J,
Greenblatt M,
Hovig E,
de Vos Tot Nederveen Cappel WH,
Sijmons RH,
Bertario L,
Tibiletti MG,
Cavestro GM,
Lindblom A,
Della Valle A,
Lopez-Köstner F,
Gluck N,
Katz LH,
Heinimann K,
Vaccaro CA,
Büttner R,
Görgens H,
Holinski-Feder E,
Morak M,
Holzapfel S,
Hüneburg R,
Knebel Doeberitz MV,
Loeffler M,
Rahner N,
Schackert HK,
Steinke-Lange V,
Schmiegel W,
Vangala D,
Pylvänäinen K,
Renkonen-Sinisalo L,
Hopper JL,
Win AK,
Haile RW,
Lindor NM,
Gallinger S,
Le Marchand L,
Newcomb PA,
Figueiredo JC,
Thibodeau SN,
Wadt K,
Therkildsen C,
Okkels H,
Ketabi Z,
Moreira L,
Sánchez A,
Serra-Burriel M,
Pineda M,
Navarro M,
Blanco I,
Green K,
Lalloo F,
Crosbie EJ,
Hill J,
Denton OG,
Frayling IM,
Rødland EA,
Vasen H,
Mints M,
Neffa F,
Esperon P,
Alvarez K,
Kariv R,
Rosner G,
Pinero TA,
Gonzalez ML,
Kalfayan P,
Tjandra D,
Winship IM,
Macrae F,
Möslein G,
Mecklin JP,
Nielsen M,
Møller P</span><br />
<span class="medgenPMjournal">Genet Med</span>
2020 Jan;22(1):15-25.
Epub 2019 Jul 24
doi: 10.1038/s41436-019-0596-9.
<span class="bold">PMID: </span><a href="/pubmed/31337882" target="_blank">31337882</a><a href="/pmc/articles/PMC7371626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2Fbrain%20cancer%20susceptibility%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (44)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/38924040">Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stastna B,
Dolezalova T,
Matejkova K,
Nemcova B,
Zemankova P,
Janatova M,
Kleiblova P,
Soukupova J,
Kleibl Z</span><br />
<span class="medgenPMjournal">Int J Cancer</span>
2024 Nov 1;155(9):1604-1615.
Epub 2024 Jun 26
doi: 10.1002/ijc.35066.
<span class="bold">PMID: </span><a href="/pubmed/38924040" target="_blank">38924040</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18020916">Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Subramanian S,
Goldstein DP,
Parlea L,
Thabane L,
Ezzat S,
Ibrahim-Zada I,
Straus S,
Brierley JD,
Tsang RW,
Gafni A,
Rotstein L,
Sawka AM</span><br />
<span class="medgenPMjournal">Thyroid</span>
2007 Dec;17(12):1277-88.
doi: 10.1089/thy.2007.0171.
<span class="bold">PMID: </span><a href="/pubmed/18020916" target="_blank">18020916</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prostate%20cancer%2Fbrain%20cancer%20susceptibility%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1863600%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (3)</a></li>
<li><a href="/gtr/tests?term=C1863600%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (5)</a></li>
<li><a href="/gtr/tests?term=C1863600%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(prostate%20cancer%2Fbrain%20cancer%20susceptibility)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Prostate%20cancer%2Fbrain%20cancer%20susceptibility%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
</div>
</div>
<div class="row">
<div class="col-lg-12 centered-lg">
<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
</li>
<li>
<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
</li>
<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
</li>
</ul>
</nav>
</div>
</div>
</div>
</section>
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