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<meta name="keywords" content="C1861063, chrna4, cigarette habituation, susceptibility to, cyp2a6, finding, gabbr2, nicotine addiction, protection from, nicotine addiction, susceptibility to, nicotine dependence, protection against, nicotine dependence, susceptibility to, slc6a3, smoking habit, susceptibility to, susceptibility to tobacco addiction, tobacco addiction, susceptibility to, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An inherited susceptibility or predisposition to developing nicotine dependence." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=348778
ConceptID=C1861063
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Tobacco addiction, susceptibility to</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>348778</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C1861063</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>CIGARETTE HABITUATION, SUSCEPTIBILITY TO</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="CHRNA4 - ID: 1137 - NCBI Gene" href="/gene/1137" class="medgenPMinfo">CHRNA4</a> (20q13.33); <a target="_blank" title="CYP2A6 - ID: 1548 - NCBI Gene" href="/gene/1548" class="medgenPMinfo">CYP2A6</a> (19q13.2); <a target="_blank" title="GABBR2 - ID: 9568 - NCBI Gene" href="/gene/9568" class="medgenPMinfo">GABBR2</a> (9q22.33); <a target="_blank" title="SLC6A3 - ID: 6531 - NCBI Gene" href="/gene/6531" class="medgenPMinfo">SLC6A3</a> (5p15.33)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0100460" target="_blank">MONDO:0100460</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/188890" target="_blank">188890</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">An inherited susceptibility or predisposition to developing nicotine dependence. [from <a title="Monarch Initiative" href="https://monarchinitiative.org/" class="defSource" target="_blank">MONDO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0028043[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=45086">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/45086" ref="tree=GTR&amp;ncbi_uid=45086&amp;link_uid=45086" title="View MedGen record for 'Nicotine dependence'">Nicotine dependence</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1861063[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=348778">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=348778" target="_blank" href="/omim/118503">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=348778" ref="ncbi_uid=348778">V</a></span></span><span class="TLline">Tobacco addiction, susceptibility to</span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/5769" ref="tree=MeSH" title="MedGen record for Impulse control disorder">Impulse control disorder</a></span><ul><li><span class="TLline"><a href="/medgen/43850" ref="tree=MeSH" title="MedGen record for Impulsivity">Impulsivity</a></span><ul><li><span class="TLline"><a href="/medgen/109373" ref="tree=MeSH" title="MedGen record for Compulsive behaviors">Compulsive behaviors</a></span><ul><li><span class="TLline"><a href="/medgen/88373" ref="tree=MeSH" title="MedGen record for Addictive behavior">Addictive behavior</a></span><ul><li><span class="TLline"><a href="/medgen/307144" ref="tree=MeSH" title="MedGen record for Drug dependence">Drug dependence</a></span><ul><li><span class="TLline"><a href="/medgen/45086" ref="tree=MeSH" title="MedGen record for Nicotine dependence">Nicotine dependence</a></span><ul><li><span class="matched_ds">Tobacco addiction, susceptibility to</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/30912847">Biomedical risk assessment as an aid for smoking cessation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Clair C,
Mueller Y,
Livingstone-Banks J,
Burnand B,
Camain JY,
Cornuz J,
Rège-Walther M,
Selby K,
Bize R</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2019 Mar 26;3(3):CD004705.
doi: 10.1002/14651858.CD004705.pub5.
<span class="bold">PMID: </span><a href="/pubmed/30912847" target="_blank">30912847</a><a href="/pmc/articles/PMC6434771" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22744911">Motivations for genetic testing for lung cancer risk among young smokers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">O'Neill SC,
Lipkus IM,
Sanderson SC,
Shepperd J,
Docherty S,
McBride CM</span><br />
<span class="medgenPMjournal">Tob Control</span>
2013 Nov;22(6):406-11.
Epub 2012 Jun 28
doi: 10.1136/tobaccocontrol-2011-050306.
<span class="bold">PMID: </span><a href="/pubmed/22744911" target="_blank">22744911</a><a href="/pmc/articles/PMC3586780" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16260030">Interest of adolescents in genetic testing for nicotine addiction susceptibility.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tercyak KP,
Peshkin BN,
Wine LA,
Walker LR</span><br />
<span class="medgenPMjournal">Prev Med</span>
2006 Jan;42(1):60-5.
Epub 2005 Nov 2
doi: 10.1016/j.ypmed.2005.09.007.
<span class="bold">PMID: </span><a href="/pubmed/16260030" target="_blank">16260030</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(tobacco%20addiction%2C%20susceptibility%20to)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (19)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng209" target="_blank">UK NICE Guideline NG209, Tobacco: preventing uptake, promoting quitting and treating dependence, 2023</a></h3>
</div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37441760">Addiction to Tobacco Smoking and Vaping.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hernández-Pérez A,
García-Gómez L,
Robles-Hernández R,
Thirión-Romero I,
Osio-Echánove J,
Rodríguez-Llamazares S,
Baler R,
Pérez-Padilla R</span><br />
<span class="medgenPMjournal">Rev Invest Clin</span>
2023;75(3):158-168.
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<span class="bold">PMID: </span><a href="/pubmed/37441760" target="_blank">37441760</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zhang Q,
Wen C</span><br />
<span class="medgenPMjournal">Front Public Health</span>
2023;11:1146949.
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<span class="bold">PMID: </span><a href="/pubmed/37255760" target="_blank">37255760</a><a href="/pmc/articles/PMC10226679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Saunders GRB,
Wang X,
Chen F,
Jang SK,
Liu M,
Wang C,
Gao S,
Jiang Y,
Khunsriraksakul C,
Otto JM,
Addison C,
Akiyama M,
Albert CM,
Aliev F,
Alonso A,
Arnett DK,
Ashley-Koch AE,
Ashrani AA,
Barnes KC,
Barr RG,
Bartz TM,
Becker DM,
Bielak LF,
Benjamin EJ,
Bis JC,
Bjornsdottir G,
Blangero J,
Bleecker ER,
Boardman JD,
Boerwinkle E,
Boomsma DI,
Boorgula MP,
Bowden DW,
Brody JA,
Cade BE,
Chasman DI,
Chavan S,
Chen YI,
Chen Z,
Cheng I,
Cho MH,
Choquet H,
Cole JW,
Cornelis MC,
Cucca F,
Curran JE,
de Andrade M,
Dick DM,
Docherty AR,
Duggirala R,
Eaton CB,
Ehringer MA,
Esko T,
Faul JD,
Fernandes Silva L,
Fiorillo E,
Fornage M,
Freedman BI,
Gabrielsen ME,
Garrett ME,
Gharib SA,
Gieger C,
Gillespie N,
Glahn DC,
Gordon SD,
Gu CC,
Gu D,
Gudbjartsson DF,
Guo X,
Haessler J,
Hall ME,
Haller T,
Harris KM,
He J,
Herd P,
Hewitt JK,
Hickie I,
Hidalgo B,
Hokanson JE,
Hopfer C,
Hottenga J,
Hou L,
Huang H,
Hung YJ,
Hunter DJ,
Hveem K,
Hwang SJ,
Hwu CM,
Iacono W,
Irvin MR,
Jee YH,
Johnson EO,
Joo YY,
Jorgenson E,
Justice AE,
Kamatani Y,
Kaplan RC,
Kaprio J,
Kardia SLR,
Keller MC,
Kelly TN,
Kooperberg C,
Korhonen T,
Kraft P,
Krauter K,
Kuusisto J,
Laakso M,
Lasky-Su J,
Lee WJ,
Lee JJ,
Levy D,
Li L,
Li K,
Li Y,
Lin K,
Lind PA,
Liu C,
Lloyd-Jones DM,
Lutz SM,
Ma J,
Mägi R,
Manichaikul A,
Martin NG,
Mathur R,
Matoba N,
McArdle PF,
McGue M,
McQueen MB,
Medland SE,
Metspalu A,
Meyers DA,
Millwood IY,
Mitchell BD,
Mohlke KL,
Moll M,
Montasser ME,
Morrison AC,
Mulas A,
Nielsen JB,
North KE,
Oelsner EC,
Okada Y,
Orrù V,
Palmer ND,
Palviainen T,
Pandit A,
Park SL,
Peters U,
Peters A,
Peyser PA,
Polderman TJC,
Rafaels N,
Redline S,
Reed RM,
Reiner AP,
Rice JP,
Rich SS,
Richmond NE,
Roan C,
Rotter JI,
Rueschman MN,
Runarsdottir V,
Saccone NL,
Schwartz DA,
Shadyab AH,
Shi J,
Shringarpure SS,
Sicinski K,
Skogholt AH,
Smith JA,
Smith NL,
Sotoodehnia N,
Stallings MC,
Stefansson H,
Stefansson K,
Stitzel JA,
Sun X,
Syed M,
Tal-Singer R,
Taylor AE,
Taylor KD,
Telen MJ,
Thai KK,
Tiwari H,
Turman C,
Tyrfingsson T,
Wall TL,
Walters RG,
Weir DR,
Weiss ST,
White WB,
Whitfield JB,
Wiggins KL,
Willemsen G,
Willer CJ,
Winsvold BS,
Xu H,
Yanek LR,
Yin J,
Young KL,
Young KA,
Yu B,
Zhao W,
Zhou W,
Zöllner S,
Zuccolo L;
23andMe Research Team;
Biobank Japan Project,
Batini C,
Bergen AW,
Bierut LJ,
David SP,
Gagliano Taliun SA,
Hancock DB,
Jiang B,
Munafò MR,
Thorgeirsson TE,
Liu DJ,
Vrieze S</span><br />
<span class="medgenPMjournal">Nature</span>
2022 Dec;612(7941):720-724.
Epub 2022 Dec 7
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<span class="bold">PMID: </span><a href="/pubmed/36477530" target="_blank">36477530</a><a href="/pmc/articles/PMC9771818" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33822437">Tobacco Use and Oral Health.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ford PJ,
Rich AM</span><br />
<span class="medgenPMjournal">Addiction</span>
2021 Dec;116(12):3531-3540.
Epub 2021 Apr 25
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<span class="bold">PMID: </span><a href="/pubmed/33822437" target="_blank">33822437</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30031636">Electronic Cigarette Harm and Benefit Perceptions and Use Among Youth.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bernat D,
Gasquet N,
Wilson KO,
Porter L,
Choi K</span><br />
<span class="medgenPMjournal">Am J Prev Med</span>
2018 Sep;55(3):361-367.
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<span class="bold">PMID: </span><a href="/pubmed/30031636" target="_blank">30031636</a><a href="/pmc/articles/PMC6168072" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Icick R,
Forget B,
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<span class="medgenPMjournal">Neuropharmacology</span>
2020 Oct 15;177:108234.
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<div class="nl"><a target="_blank" href="/pubmed/26503903">Secondhand tobacco smoke exposure and susceptibility to smoking, perceived addiction, and psychobehavioral symptoms among college students.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Okoli CT,
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<span class="medgenPMjournal">J Am Coll Health</span>
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<div class="nl"><a target="_blank" href="/pubmed/18305452">Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Benowitz NL</span><br />
<span class="medgenPMjournal">Clin Pharmacol Ther</span>
2008 Apr;83(4):531-41.
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<div class="nl"><a target="_blank" href="/pubmed/15886412">Pharmacokinetics and metabolism of nicotine.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tutka P,
Mosiewicz J,
Wielosz M</span><br />
<span class="medgenPMjournal">Pharmacol Rep</span>
2005 Mar-Apr;57(2):143-53.
<span class="bold">PMID: </span><a href="/pubmed/15886412" target="_blank">15886412</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37441760">Addiction to Tobacco Smoking and Vaping.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hernández-Pérez A,
García-Gómez L,
Robles-Hernández R,
Thirión-Romero I,
Osio-Echánove J,
Rodríguez-Llamazares S,
Baler R,
Pérez-Padilla R</span><br />
<span class="medgenPMjournal">Rev Invest Clin</span>
2023;75(3):158-168.
doi: 10.24875/RIC.23000117.
<span class="bold">PMID: </span><a href="/pubmed/37441760" target="_blank">37441760</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37255760">The risk profile of electronic nicotine delivery systems, compared to traditional cigarettes, on oral disease: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang Q,
Wen C</span><br />
<span class="medgenPMjournal">Front Public Health</span>
2023;11:1146949.
Epub 2023 May 15
doi: 10.3389/fpubh.2023.1146949.
<span class="bold">PMID: </span><a href="/pubmed/37255760" target="_blank">37255760</a><a href="/pmc/articles/PMC10226679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30031636">Electronic Cigarette Harm and Benefit Perceptions and Use Among Youth.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bernat D,
Gasquet N,
Wilson KO,
Porter L,
Choi K</span><br />
<span class="medgenPMjournal">Am J Prev Med</span>
2018 Sep;55(3):361-367.
Epub 2018 Jul 19
doi: 10.1016/j.amepre.2018.04.043.
<span class="bold">PMID: </span><a href="/pubmed/30031636" target="_blank">30031636</a><a href="/pmc/articles/PMC6168072" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19393973">Nicotinic receptors and nicotine addiction.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Changeux JP</span><br />
<span class="medgenPMjournal">C R Biol</span>
2009 May;332(5):421-5.
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<div class="nl"><a target="_blank" href="/pubmed/11720739">Molecular biology of lung cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kaye FJ</span><br />
<span class="medgenPMjournal">Lung Cancer</span>
2001 Dec;34 Suppl 2:S35-41.
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<span class="bold">PMID: </span><a href="/pubmed/11720739" target="_blank">11720739</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tobacco%20addiction%2C%20susceptibility%20to%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (123)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36477530">Genetic diversity fuels gene discovery for tobacco and alcohol use.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saunders GRB,
Wang X,
Chen F,
Jang SK,
Liu M,
Wang C,
Gao S,
Jiang Y,
Khunsriraksakul C,
Otto JM,
Addison C,
Akiyama M,
Albert CM,
Aliev F,
Alonso A,
Arnett DK,
Ashley-Koch AE,
Ashrani AA,
Barnes KC,
Barr RG,
Bartz TM,
Becker DM,
Bielak LF,
Benjamin EJ,
Bis JC,
Bjornsdottir G,
Blangero J,
Bleecker ER,
Boardman JD,
Boerwinkle E,
Boomsma DI,
Boorgula MP,
Bowden DW,
Brody JA,
Cade BE,
Chasman DI,
Chavan S,
Chen YI,
Chen Z,
Cheng I,
Cho MH,
Choquet H,
Cole JW,
Cornelis MC,
Cucca F,
Curran JE,
de Andrade M,
Dick DM,
Docherty AR,
Duggirala R,
Eaton CB,
Ehringer MA,
Esko T,
Faul JD,
Fernandes Silva L,
Fiorillo E,
Fornage M,
Freedman BI,
Gabrielsen ME,
Garrett ME,
Gharib SA,
Gieger C,
Gillespie N,
Glahn DC,
Gordon SD,
Gu CC,
Gu D,
Gudbjartsson DF,
Guo X,
Haessler J,
Hall ME,
Haller T,
Harris KM,
He J,
Herd P,
Hewitt JK,
Hickie I,
Hidalgo B,
Hokanson JE,
Hopfer C,
Hottenga J,
Hou L,
Huang H,
Hung YJ,
Hunter DJ,
Hveem K,
Hwang SJ,
Hwu CM,
Iacono W,
Irvin MR,
Jee YH,
Johnson EO,
Joo YY,
Jorgenson E,
Justice AE,
Kamatani Y,
Kaplan RC,
Kaprio J,
Kardia SLR,
Keller MC,
Kelly TN,
Kooperberg C,
Korhonen T,
Kraft P,
Krauter K,
Kuusisto J,
Laakso M,
Lasky-Su J,
Lee WJ,
Lee JJ,
Levy D,
Li L,
Li K,
Li Y,
Lin K,
Lind PA,
Liu C,
Lloyd-Jones DM,
Lutz SM,
Ma J,
Mägi R,
Manichaikul A,
Martin NG,
Mathur R,
Matoba N,
McArdle PF,
McGue M,
McQueen MB,
Medland SE,
Metspalu A,
Meyers DA,
Millwood IY,
Mitchell BD,
Mohlke KL,
Moll M,
Montasser ME,
Morrison AC,
Mulas A,
Nielsen JB,
North KE,
Oelsner EC,
Okada Y,
Orrù V,
Palmer ND,
Palviainen T,
Pandit A,
Park SL,
Peters U,
Peters A,
Peyser PA,
Polderman TJC,
Rafaels N,
Redline S,
Reed RM,
Reiner AP,
Rice JP,
Rich SS,
Richmond NE,
Roan C,
Rotter JI,
Rueschman MN,
Runarsdottir V,
Saccone NL,
Schwartz DA,
Shadyab AH,
Shi J,
Shringarpure SS,
Sicinski K,
Skogholt AH,
Smith JA,
Smith NL,
Sotoodehnia N,
Stallings MC,
Stefansson H,
Stefansson K,
Stitzel JA,
Sun X,
Syed M,
Tal-Singer R,
Taylor AE,
Taylor KD,
Telen MJ,
Thai KK,
Tiwari H,
Turman C,
Tyrfingsson T,
Wall TL,
Walters RG,
Weir DR,
Weiss ST,
White WB,
Whitfield JB,
Wiggins KL,
Willemsen G,
Willer CJ,
Winsvold BS,
Xu H,
Yanek LR,
Yin J,
Young KL,
Young KA,
Yu B,
Zhao W,
Zhou W,
Zöllner S,
Zuccolo L;
23andMe Research Team;
Biobank Japan Project,
Batini C,
Bergen AW,
Bierut LJ,
David SP,
Gagliano Taliun SA,
Hancock DB,
Jiang B,
Munafò MR,
Thorgeirsson TE,
Liu DJ,
Vrieze S</span><br />
<span class="medgenPMjournal">Nature</span>
2022 Dec;612(7941):720-724.
Epub 2022 Dec 7
doi: 10.1038/s41586-022-05477-4.
<span class="bold">PMID: </span><a href="/pubmed/36477530" target="_blank">36477530</a><a href="/pmc/articles/PMC9771818" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ford PJ,
Rich AM</span><br />
<span class="medgenPMjournal">Addiction</span>
2021 Dec;116(12):3531-3540.
Epub 2021 Apr 25
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<span class="bold">PMID: </span><a href="/pubmed/33822437" target="_blank">33822437</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hancock DB,
Reginsson GW,
Gaddis NC,
Chen X,
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Brüske I,
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Kaprio J,
Kranzler HR,
Gelernter J,
Baker TB,
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<div class="portlet_content ln"><span class="medgenPMauthor">Kaye FJ</span><br />
<span class="medgenPMjournal">Lung Cancer</span>
2001 Dec;34 Suppl 2:S35-41.
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<span class="bold">PMID: </span><a href="/pubmed/11720739" target="_blank">11720739</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Saleh EA,
Lazaridou FB,
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Wazaify M,
Heinz A,
Kluge U</span><br />
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<div class="portlet_content ln"><span class="medgenPMauthor">Saunders GRB,
Wang X,
Chen F,
Jang SK,
Liu M,
Wang C,
Gao S,
Jiang Y,
Khunsriraksakul C,
Otto JM,
Addison C,
Akiyama M,
Albert CM,
Aliev F,
Alonso A,
Arnett DK,
Ashley-Koch AE,
Ashrani AA,
Barnes KC,
Barr RG,
Bartz TM,
Becker DM,
Bielak LF,
Benjamin EJ,
Bis JC,
Bjornsdottir G,
Blangero J,
Bleecker ER,
Boardman JD,
Boerwinkle E,
Boomsma DI,
Boorgula MP,
Bowden DW,
Brody JA,
Cade BE,
Chasman DI,
Chavan S,
Chen YI,
Chen Z,
Cheng I,
Cho MH,
Choquet H,
Cole JW,
Cornelis MC,
Cucca F,
Curran JE,
de Andrade M,
Dick DM,
Docherty AR,
Duggirala R,
Eaton CB,
Ehringer MA,
Esko T,
Faul JD,
Fernandes Silva L,
Fiorillo E,
Fornage M,
Freedman BI,
Gabrielsen ME,
Garrett ME,
Gharib SA,
Gieger C,
Gillespie N,
Glahn DC,
Gordon SD,
Gu CC,
Gu D,
Gudbjartsson DF,
Guo X,
Haessler J,
Hall ME,
Haller T,
Harris KM,
He J,
Herd P,
Hewitt JK,
Hickie I,
Hidalgo B,
Hokanson JE,
Hopfer C,
Hottenga J,
Hou L,
Huang H,
Hung YJ,
Hunter DJ,
Hveem K,
Hwang SJ,
Hwu CM,
Iacono W,
Irvin MR,
Jee YH,
Johnson EO,
Joo YY,
Jorgenson E,
Justice AE,
Kamatani Y,
Kaplan RC,
Kaprio J,
Kardia SLR,
Keller MC,
Kelly TN,
Kooperberg C,
Korhonen T,
Kraft P,
Krauter K,
Kuusisto J,
Laakso M,
Lasky-Su J,
Lee WJ,
Lee JJ,
Levy D,
Li L,
Li K,
Li Y,
Lin K,
Lind PA,
Liu C,
Lloyd-Jones DM,
Lutz SM,
Ma J,
Mägi R,
Manichaikul A,
Martin NG,
Mathur R,
Matoba N,
McArdle PF,
McGue M,
McQueen MB,
Medland SE,
Metspalu A,
Meyers DA,
Millwood IY,
Mitchell BD,
Mohlke KL,
Moll M,
Montasser ME,
Morrison AC,
Mulas A,
Nielsen JB,
North KE,
Oelsner EC,
Okada Y,
Orrù V,
Palmer ND,
Palviainen T,
Pandit A,
Park SL,
Peters U,
Peters A,
Peyser PA,
Polderman TJC,
Rafaels N,
Redline S,
Reed RM,
Reiner AP,
Rice JP,
Rich SS,
Richmond NE,
Roan C,
Rotter JI,
Rueschman MN,
Runarsdottir V,
Saccone NL,
Schwartz DA,
Shadyab AH,
Shi J,
Shringarpure SS,
Sicinski K,
Skogholt AH,
Smith JA,
Smith NL,
Sotoodehnia N,
Stallings MC,
Stefansson H,
Stefansson K,
Stitzel JA,
Sun X,
Syed M,
Tal-Singer R,
Taylor AE,
Taylor KD,
Telen MJ,
Thai KK,
Tiwari H,
Turman C,
Tyrfingsson T,
Wall TL,
Walters RG,
Weir DR,
Weiss ST,
White WB,
Whitfield JB,
Wiggins KL,
Willemsen G,
Willer CJ,
Winsvold BS,
Xu H,
Yanek LR,
Yin J,
Young KL,
Young KA,
Yu B,
Zhao W,
Zhou W,
Zöllner S,
Zuccolo L;
23andMe Research Team;
Biobank Japan Project,
Batini C,
Bergen AW,
Bierut LJ,
David SP,
Gagliano Taliun SA,
Hancock DB,
Jiang B,
Munafò MR,
Thorgeirsson TE,
Liu DJ,
Vrieze S</span><br />
<span class="medgenPMjournal">Nature</span>
2022 Dec;612(7941):720-724.
Epub 2022 Dec 7
doi: 10.1038/s41586-022-05477-4.
<span class="bold">PMID: </span><a href="/pubmed/36477530" target="_blank">36477530</a><a href="/pmc/articles/PMC9771818" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34779080">A polygenic approach to the association between smoking and schizophrenia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Soufi L,
Martorell L,
Moltó MD,
González-Peñas J,
García-Portilla MP,
Arrojo M,
Rivero O,
Gutiérrez-Zotes A,
Nácher J,
Muntané G,
Paz E,
Páramo M,
Bobes J,
Arango C,
Sanjuan J,
Vilella E,
Costas J</span><br />
<span class="medgenPMjournal">Addict Biol</span>
2022 Jan;27(1):e13104.
Epub 2021 Nov 14
doi: 10.1111/adb.13104.
<span class="bold">PMID: </span><a href="/pubmed/34779080" target="_blank">34779080</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26669465">To quit or not: Vulnerability of women to smoking tobacco.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Park SJ,
Yi B,
Lee HS,
Oh WY,
Na HK,
Lee M,
Yang M</span><br />
<span class="medgenPMjournal">J Environ Sci Health C Environ Carcinog Ecotoxicol Rev</span>
2016;34(1):33-56.
doi: 10.1080/10590501.2015.1131539.
<span class="bold">PMID: </span><a href="/pubmed/26669465" target="_blank">26669465</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26440539">Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hancock DB,
Reginsson GW,
Gaddis NC,
Chen X,
Saccone NL,
Lutz SM,
Qaiser B,
Sherva R,
Steinberg S,
Zink F,
Stacey SN,
Glasheen C,
Chen J,
Gu F,
Frederiksen BN,
Loukola A,
Gudbjartsson DF,
Brüske I,
Landi MT,
Bickeböller H,
Madden P,
Farrer L,
Kaprio J,
Kranzler HR,
Gelernter J,
Baker TB,
Kraft P,
Amos CI,
Caporaso NE,
Hokanson JE,
Bierut LJ,
Thorgeirsson TE,
Johnson EO,
Stefansson K</span><br />
<span class="medgenPMjournal">Transl Psychiatry</span>
2015 Oct 6;5(10):e651.
doi: 10.1038/tp.2015.149.
<span class="bold">PMID: </span><a href="/pubmed/26440539" target="_blank">26440539</a><a href="/pmc/articles/PMC4930126" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tobacco%20addiction%2C%20susceptibility%20to%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (149)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/37591107">Viral Vaping: A systematic review and meta analysis of e-cigarette and Tobacco-Related social media content and its influence on youth behaviours and attitudes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rutherford BN,
Lim CCW,
Cheng B,
Sun T,
Vu GT,
Johnson B,
Daniel Paul Ashley,
Chung J,
Huang S,
Leung J,
Stjepanović D,
Connor JP,
Chan GCK</span><br />
<span class="medgenPMjournal">Addict Behav</span>
2023 Dec;147:107828.
Epub 2023 Aug 6
doi: 10.1016/j.addbeh.2023.107828.
<span class="bold">PMID: </span><a href="/pubmed/37591107" target="_blank">37591107</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35929580">A systematic review of qualitative research on substance use among refugees.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saleh EA,
Lazaridou FB,
Klapprott F,
Wazaify M,
Heinz A,
Kluge U</span><br />
<span class="medgenPMjournal">Addiction</span>
2023 Feb;118(2):218-253.
Epub 2022 Sep 5
doi: 10.1111/add.16021.
<span class="bold">PMID: </span><a href="/pubmed/35929580" target="_blank">35929580</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35491750">Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chang XW,
Sun Y,
Muhai JN,
Li YY,
Chen Y,
Lu L,
Chang SH,
Shi J</span><br />
<span class="medgenPMjournal">Addiction</span>
2022 Sep;117(9):2515-2529.
Epub 2022 May 10
doi: 10.1111/add.15908.
<span class="bold">PMID: </span><a href="/pubmed/35491750" target="_blank">35491750</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26669465">To quit or not: Vulnerability of women to smoking tobacco.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Park SJ,
Yi B,
Lee HS,
Oh WY,
Na HK,
Lee M,
Yang M</span><br />
<span class="medgenPMjournal">J Environ Sci Health C Environ Carcinog Ecotoxicol Rev</span>
2016;34(1):33-56.
doi: 10.1080/10590501.2015.1131539.
<span class="bold">PMID: </span><a href="/pubmed/26669465" target="_blank">26669465</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22912735">Association of betel nut with carcinogenesis: revisit with a clinical perspective.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sharan RN,
Mehrotra R,
Choudhury Y,
Asotra K</span><br />
<span class="medgenPMjournal">PLoS One</span>
2012;7(8):e42759.
Epub 2012 Aug 13
doi: 10.1371/journal.pone.0042759.
<span class="bold">PMID: </span><a href="/pubmed/22912735" target="_blank">22912735</a><a href="/pmc/articles/PMC3418282" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tobacco%20addiction%2C%20susceptibility%20to%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (12)</a></div></div>
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<div class="supplemental col three_col last">
<h2 class="offscreen_noflow">Supplemental Content</h2>
<div>
<!-- MedGen supplemental column starts here -->
<div class="rightCol mgCol">
<div class="portlet mgSection" id="ID_113">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
</div>
<div class="portlet mgSection" id="ID_106">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1861063%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (28)</a></li>
<li><a href="/gtr/tests?term=C1861063%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (32)</a></li>
<li><a href="/gtr/tests?term=C1861063%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1861063%5bDISCUI%5d" target="_blank">See all (37)</a></total></li>
</ul></div>
</div>
<div class="portlet mgSection" id="ID_119">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=188890" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Tobacco%20addiction,%20susceptibility%20to" target="_blank">ClinicalTrials.gov</a></li></ul></div>
</div>
<div class="portlet mgSection" id="ID_121">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(tobacco%20addiction%2C%20susceptibility%20to)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Tobacco%20addiction%2C%20susceptibility%20to%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng209">NICE, 2023</a><div>UK NICE Guideline NG209, Tobacco: preventing uptake, promoting quitting and treating dependence, 2023</div></li></ul></div>
</div>
<div class="portlet mgSection" id="ID_115">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=118504%20122720%20126455%20607340" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=1137[geneid]" target="_blank">View CHRNA4 variations in ClinVar</a></li><li><a href="/clinvar/?term=1548[geneid]" target="_blank">View CYP2A6 variations in ClinVar</a></li><li><a href="/clinvar/?term=6531[geneid]" target="_blank">View SLC6A3 variations in ClinVar</a></li><li><a href="/clinvar/?term=9568[geneid]" target="_blank">View GABBR2 variations in ClinVar</a></li><li><a href="/nuccore/197100415,227496937,269784774,284521645" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=188890" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
</div>
<div class="portlet mgSection" id="ID_116">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Tobacco+addiction%2C+susceptibility+to/9410" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/tobacco_addiction" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&amp;query=Tobacco%20addiction,%20susceptibility%20to" target="_blank">MedlinePlus</a></li></ul></div>
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<h3>Reviews</h3>
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<a href="/pubmed/clinical?term=Tobacco%20addiction,%20susceptibility%20to" ref="ncbi_uid=&amp;discoId=gtr_reviews&amp;linkpos=1&amp;linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
</li>
<li>
<a href="/pubmed?term=Tobacco%20addiction,%20susceptibility%20to%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&amp;discoId=gtr_reviews&amp;linkpos=2&amp;linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<!-- MedGen supplemental column ends here -->
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<h3>Related information</h3>
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<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=348778" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&amp;from_uid=348778" ref="log$=recordlinks">Gene</a>
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1861063[DISCUI]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1861063[DISCUI]&amp;test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&amp;from_uid=348778" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
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<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&amp;from_uid=348778" ref="log$=recordlinks">OMIM(Genes)</a>
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&amp;from_uid=348778" ref="log$=recordlinks">PMC Articles</a>
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&amp;from_uid=348778" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&amp;from_uid=348778" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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