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<meta name="keywords" content="C0431109, anaplastic choroid plexus papilloma, cancer of choroid plexus, cancer of the choroid plexus, carcinoma of choroid plexus, carcinoma of the choroid plexus, carcinoma, choroid plexus, malignant, choroid plexus cancer, choroid plexus carcinoma, choroid plexus carcinoma (morphologic abnormality), choroid plexus papilloma, anaplastic, choroid plexus papilloma, malignant, cpc, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Intraventricular papillary neoplasm derived from choroid plexus epithelium. Plexus tumors are most common in the lateral and fourth ventricles; while 80% of lateral ventricle tumors present in children, fourth ventricle tumors are evenly distributed in all age groups. Clinically, choroid plexus tumors tend to cause hydrocephalus and increased intracranial pressure. Histologically, choroid plexus papillomas correspond to WHO grade I, choroid plexus carcinomas to WHO grade III." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Choroid plexus carcinoma (Concept Id: C0431109)
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<!--
UID=96557
ConceptID=C0431109
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Choroid plexus carcinoma<span class="h1sub">(CPC)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>96557</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0431109</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>CPC</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Choroid plexus papilloma, malignant (88252006); Choroid plexus papilloma, anaplastic (88252006); Choroid plexus carcinoma (88252006); Choroid plexus carcinoma (1156471001)</td></tr>
<tr><td>Modes of inheritance:</td>
<td>
<div class="divPopper rprt" id="moi_141047"><div><strong>Autosomal dominant inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141047</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0443147</a></dd><dt><span class="dotprefix"></span></dt><dd>Intellectual Product</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.</div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant inheritance</a><span> (Orphanet)</span></div></td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030392">HP:0030392</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0016718" target="_blank">MONDO:0016718</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/191170" target="_blank">191170</a>; <a href="https://omim.org/entry/260500" target="_blank">260500</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=251899">ORPHA251899</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Intraventricular papillary neoplasm derived from choroid plexus epithelium. Plexus tumors are most common in the lateral and fourth ventricles; while 80% of lateral ventricle tumors present in children, fourth ventricle tumors are evenly distributed in all age groups. Clinically, choroid plexus tumors tend to cause hydrocephalus and increased intracranial pressure. Histologically, choroid plexus papillomas correspond to WHO grade I, choroid plexus carcinomas to WHO grade III. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0431109[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=96557">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=96557" target="_blank" href="/omim/191170">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=96557" ref="ncbi_uid=96557">V</a></span></span><span class="TLline">Choroid plexus carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/363605" ref="tree=MeSH" title="MedGen record for Central Nervous System Carcinoma">Central Nervous System Carcinoma</a></span><ul><li><span class="matched_ds">Choroid plexus carcinoma</span><ul><li><span class="TLline"><a href="/medgen/901899" ref="tree=MeSH" title="MedGen record for Childhood choroid plexus carcinoma">Childhood choroid plexus carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&amp;data_id=156&amp;PatId=19690&amp;search=Disease_Classif_Simple&amp;new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Choroid plexus carcinoma</span> in Orphanet.</div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_322892"><div><strong>Rhabdoid tumor predisposition syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322892</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1836327</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The rhabdoid tumor predisposition syndrome is an autosomal dominant cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors (Sevenet et al., 1999).&#13; Rhabdoid tumors are a highly malignant group of neoplasms that usually occur in children less than 2 years of age. Malignant rhabdoid tumors (MRTs) of the kidney were first described as a sarcomatous variant of Wilms tumors (Beckwith and Palmer, 1978). Later, extrarenal rhabdoid tumor was reported in numerous locations, including the central nervous system (CNS) (Parham et al., 1994). Classification has been difficult because of considerable variation in the histologic and immunologic characteristics within and between rhabdoid tumors of the liver, soft tissues, and CNS. In the CNS, rhabdoid tumors may be pure rhabdoid tumors or a variant that has been designated atypical teratoid tumor (AT/RT).&#13; Genetic Heterogeneity of Rhabdoid Tumor Predisposition Syndrome&#13; See also RTPS2 (613325), caused by germline mutation in the SMARCA4 gene (603254) on chromosome 19p13.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/322892">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_348508"><div><strong>Adrenocortical carcinoma, hereditary</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>348508</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1859972</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">Adrenocortical carcinoma (ADCC) is a rare but aggressive childhood tumor, representing about 0.4% of childhood tumors, with a high incidence of associated tumors. ADCC occurs with increased frequency in patients with the Beckwith-Wiedemann syndrome (130650) and is a component tumor in Li-Fraumeni syndrome (LFS; 151623).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/348508">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_348508" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Adrenocortical carcinoma, hereditary</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322892" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rhabdoid tumor predisposition syndrome 1</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34003555">Triple intraventricular chemotherapy for treatment of relapsed choroid plexus carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lau G,
Drummond J,
Zhukova N,
Wood P,
Janson L</span><br />
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
2021 Sep;68(9):e29094.
Epub 2021 May 18
doi: 10.1002/pbc.29094.
<span class="bold">PMID: </span><a href="/pubmed/34003555" target="_blank">34003555</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32342334">Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thomas C,
Metrock K,
Kordes U,
Hasselblatt M,
Dhall G</span><br />
<span class="medgenPMjournal">J Neurooncol</span>
2020 May;148(1):39-45.
Epub 2020 Apr 28
doi: 10.1007/s11060-020-03509-5.
<span class="bold">PMID: </span><a href="/pubmed/32342334" target="_blank">32342334</a><a href="/pmc/articles/PMC7280353" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24068529">Current management of choroid plexus carcinomas.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sun MZ,
Oh MC,
Ivan ME,
Kaur G,
Safaee M,
Kim JM,
Phillips JJ,
Auguste KI,
Parsa AT</span><br />
<span class="medgenPMjournal">Neurosurg Rev</span>
2014 Apr;37(2):179-92; discussion 192.
Epub 2013 Sep 26
doi: 10.1007/s10143-013-0499-1.
<span class="bold">PMID: </span><a href="/pubmed/24068529" target="_blank">24068529</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22choroid%20plexus%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (18)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/32671623">Frequency of the TP53 p.R337H mutation in a Brazilian cohort of pediatric patients with solid tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Feitosa JADS,
das Chagas PF,
de Sousa GR,
Queiroz RGP,
Cruzeiro GAV,
Tone LG,
Borges KS,
Valera ET</span><br />
<span class="medgenPMjournal">Mol Biol Rep</span>
2020 Aug;47(8):6439-6443.
Epub 2020 Jul 15
doi: 10.1007/s11033-020-05655-5.
<span class="bold">PMID: </span><a href="/pubmed/32671623" target="_blank">32671623</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31468188">An update on the central nervous system manifestations of Li-Fraumeni syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Orr BA,
Clay MR,
Pinto EM,
Kesserwan C</span><br />
<span class="medgenPMjournal">Acta Neuropathol</span>
2020 Apr;139(4):669-687.
Epub 2019 Aug 30
doi: 10.1007/s00401-019-02055-3.
<span class="bold">PMID: </span><a href="/pubmed/31468188" target="_blank">31468188</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30953158">Perinatal (fetal and neonatal) choroid plexus tumors: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Crawford JR,
Isaacs H Jr</span><br />
<span class="medgenPMjournal">Childs Nerv Syst</span>
2019 Jun;35(6):937-944.
Epub 2019 Apr 5
doi: 10.1007/s00381-019-04135-x.
<span class="bold">PMID: </span><a href="/pubmed/30953158" target="_blank">30953158</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29528196">Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zaky W,
Finlay JL</span><br />
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
2018 Jul;65(7):e27031.
Epub 2018 Mar 12
doi: 10.1002/pbc.27031.
<span class="bold">PMID: </span><a href="/pubmed/29528196" target="_blank">29528196</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8979596">Choroid plexus carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chopra K,
Iyer S,
Matta SK,
Gupta A,
Malhotra V</span><br />
<span class="medgenPMjournal">Indian Pediatr</span>
1996 May;33(5):420-2.
<span class="bold">PMID: </span><a href="/pubmed/8979596" target="_blank">8979596</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Choroid%20plexus%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (103)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37452939">Tumors of Choroid Plexus and Other Ventricular Tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spennato P,
De Martino L,
Russo C,
Errico ME,
Imperato A,
Mazio F,
Miccoli G,
Quaglietta L,
Abate M,
Covelli E,
Donofrio V,
Cinalli G</span><br />
<span class="medgenPMjournal">Adv Exp Med Biol</span>
2023;1405:175-223.
doi: 10.1007/978-3-031-23705-8_7.
<span class="bold">PMID: </span><a href="/pubmed/37452939" target="_blank">37452939</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32969735">Choroid Plexus Carcinoma with Hyaline Globules: An Uncommon Histological Finding.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jha S,
Purkait S,
Dash C,
Lalsangzuala C</span><br />
<span class="medgenPMjournal">Fetal Pediatr Pathol</span>
2022 Jun;41(3):464-467.
Epub 2020 Sep 24
doi: 10.1080/15513815.2020.1822966.
<span class="bold">PMID: </span><a href="/pubmed/32969735" target="_blank">32969735</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31468188">An update on the central nervous system manifestations of Li-Fraumeni syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Orr BA,
Clay MR,
Pinto EM,
Kesserwan C</span><br />
<span class="medgenPMjournal">Acta Neuropathol</span>
2020 Apr;139(4):669-687.
Epub 2019 Aug 30
doi: 10.1007/s00401-019-02055-3.
<span class="bold">PMID: </span><a href="/pubmed/31468188" target="_blank">31468188</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30138862">MRI of intracranial intraventricular lesions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Muly S,
Liu S,
Lee R,
Nicolaou S,
Rojas R,
Khosa F</span><br />
<span class="medgenPMjournal">Clin Imaging</span>
2018 Nov-Dec;52:226-239.
Epub 2018 Aug 1
doi: 10.1016/j.clinimag.2018.07.021.
<span class="bold">PMID: </span><a href="/pubmed/30138862" target="_blank">30138862</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8979596">Choroid plexus carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chopra K,
Iyer S,
Matta SK,
Gupta A,
Malhotra V</span><br />
<span class="medgenPMjournal">Indian Pediatr</span>
1996 May;33(5):420-2.
<span class="bold">PMID: </span><a href="/pubmed/8979596" target="_blank">8979596</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Choroid%20plexus%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (166)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/34997889">Final results of the Choroid Plexus Tumor study CPT-SIOP-2000.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wolff JE,
Van Gool SW,
Kutluk T,
Diez B,
Kebudi R,
Timmermann B,
Garami M,
Sterba J,
Fuller GN,
Bison B,
Kordes UR</span><br />
<span class="medgenPMjournal">J Neurooncol</span>
2022 Feb;156(3):599-613.
Epub 2022 Jan 8
doi: 10.1007/s11060-021-03942-0.
<span class="bold">PMID: </span><a href="/pubmed/34997889" target="_blank">34997889</a><a href="/pmc/articles/PMC8860833" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31536979">Transventricular Migration of Choroid Plexus Carcinoma Causing an Intraoperative Conundrum: A Case Report with a Review of the Literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ratha V,
Kumar VRR</span><br />
<span class="medgenPMjournal">Pediatr Neurosurg</span>
2019;54(5):341-346.
Epub 2019 Sep 19
doi: 10.1159/000500300.
<span class="bold">PMID: </span><a href="/pubmed/31536979" target="_blank">31536979</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28939225">Effect of Surgery, Adjuvant Therapy, and Other Prognostic Factors on Choroid Plexus Carcinoma: A Systematic Review and Individual Patient Data Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mallick S,
Benson R,
Melgandi W,
Rath GK</span><br />
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
2017 Dec 1;99(5):1199-1206.
Epub 2017 Aug 18
doi: 10.1016/j.ijrobp.2017.08.012.
<span class="bold">PMID: </span><a href="/pubmed/28939225" target="_blank">28939225</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25662896">Choroid plexus carcinoma in children: the Head Start experience.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zaky W,
Dhall G,
Khatua S,
Brown RJ,
Ginn KF,
Gardner SL,
Yildiz VO,
Yankelevich M,
Finlay JL</span><br />
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
2015 May;62(5):784-9.
Epub 2015 Feb 8
doi: 10.1002/pbc.25436.
<span class="bold">PMID: </span><a href="/pubmed/25662896" target="_blank">25662896</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10550588">Chemotherapy of choroid plexus carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Greenberg ML</span><br />
<span class="medgenPMjournal">Childs Nerv Syst</span>
1999 Oct;15(10):571-7.
doi: 10.1007/s003810050545.
<span class="bold">PMID: </span><a href="/pubmed/10550588" target="_blank">10550588</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Choroid%20plexus%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (60)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/32342334">Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thomas C,
Metrock K,
Kordes U,
Hasselblatt M,
Dhall G</span><br />
<span class="medgenPMjournal">J Neurooncol</span>
2020 May;148(1):39-45.
Epub 2020 Apr 28
doi: 10.1007/s11060-020-03509-5.
<span class="bold">PMID: </span><a href="/pubmed/32342334" target="_blank">32342334</a><a href="/pmc/articles/PMC7280353" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31375903">Subgroup-specific outcomes of children with malignant childhood brain tumors treated with an irradiation-sparing protocol.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hidalgo ET,
Snuderl M,
Orillac C,
Kvint S,
Serrano J,
Wu P,
Karajannis MA,
Gardner SL</span><br />
<span class="medgenPMjournal">Childs Nerv Syst</span>
2020 Jan;36(1):133-144.
Epub 2019 Aug 2
doi: 10.1007/s00381-019-04305-x.
<span class="bold">PMID: </span><a href="/pubmed/31375903" target="_blank">31375903</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29528196">Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zaky W,
Finlay JL</span><br />
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
2018 Jul;65(7):e27031.
Epub 2018 Mar 12
doi: 10.1002/pbc.27031.
<span class="bold">PMID: </span><a href="/pubmed/29528196" target="_blank">29528196</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18684041">Choroid plexus carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gopal P,
Parker JR,
Debski R,
Parker JC Jr</span><br />
<span class="medgenPMjournal">Arch Pathol Lab Med</span>
2008 Aug;132(8):1350-4.
doi: 10.5858/2008-132-1350-CPC.
<span class="bold">PMID: </span><a href="/pubmed/18684041" target="_blank">18684041</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8979596">Choroid plexus carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chopra K,
Iyer S,
Matta SK,
Gupta A,
Malhotra V</span><br />
<span class="medgenPMjournal">Indian Pediatr</span>
1996 May;33(5):420-2.
<span class="bold">PMID: </span><a href="/pubmed/8979596" target="_blank">8979596</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Choroid%20plexus%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (121)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/36056180">Nervous system (NS) Tumors in Cancer Predisposition Syndromes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Patil P,
Pencheva BB,
Patil VM,
Fangusaro J</span><br />
<span class="medgenPMjournal">Neurotherapeutics</span>
2022 Oct;19(6):1752-1771.
Epub 2022 Sep 2
doi: 10.1007/s13311-022-01277-w.
<span class="bold">PMID: </span><a href="/pubmed/36056180" target="_blank">36056180</a><a href="/pmc/articles/PMC9723057" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33203591">Pediatric atypical choroid plexus papilloma: Clinical features and diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chen Y,
Zhao R,
Shi W,
Li H</span><br />
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
2021 Jan;200:106345.
Epub 2020 Nov 4
doi: 10.1016/j.clineuro.2020.106345.
<span class="bold">PMID: </span><a href="/pubmed/33203591" target="_blank">33203591</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32671623">Frequency of the TP53 p.R337H mutation in a Brazilian cohort of pediatric patients with solid tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Feitosa JADS,
das Chagas PF,
de Sousa GR,
Queiroz RGP,
Cruzeiro GAV,
Tone LG,
Borges KS,
Valera ET</span><br />
<span class="medgenPMjournal">Mol Biol Rep</span>
2020 Aug;47(8):6439-6443.
Epub 2020 Jul 15
doi: 10.1007/s11033-020-05655-5.
<span class="bold">PMID: </span><a href="/pubmed/32671623" target="_blank">32671623</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29737433">Report of a bi-allelic truncating germline mutation in TP53.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brown NJ,
Bhatia K,
Teague J,
White SM,
Lo P,
Challis J,
Beshay V,
Sullivan M,
Malkin D,
Hansford JR</span><br />
<span class="medgenPMjournal">Fam Cancer</span>
2019 Jan;18(1):101-104.
doi: 10.1007/s10689-018-0087-1.
<span class="bold">PMID: </span><a href="/pubmed/29737433" target="_blank">29737433</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22821924">Imaging changes in very young children with brain tumors treated with proton therapy and chemotherapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sabin ND,
Merchant TE,
Harreld JH,
Patay Z,
Klimo P Jr,
Qaddoumi I,
Armstrong GT,
Wright K,
Gray J,
Indelicato DJ,
Gajjar A</span><br />
<span class="medgenPMjournal">AJNR Am J Neuroradiol</span>
2013 Feb;34(2):446-50.
Epub 2012 Jul 19
doi: 10.3174/ajnr.A3219.
<span class="bold">PMID: </span><a href="/pubmed/22821924" target="_blank">22821924</a><a href="/pmc/articles/PMC3573244" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Choroid%20plexus%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (60)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/28939225">Effect of Surgery, Adjuvant Therapy, and Other Prognostic Factors on Choroid Plexus Carcinoma: A Systematic Review and Individual Patient Data Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mallick S,
Benson R,
Melgandi W,
Rath GK</span><br />
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
2017 Dec 1;99(5):1199-1206.
Epub 2017 Aug 18
doi: 10.1016/j.ijrobp.2017.08.012.
<span class="bold">PMID: </span><a href="/pubmed/28939225" target="_blank">28939225</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Choroid%20plexus%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet mgSection" id="ID_113">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0431109%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (27)</a></li>
<li><a href="/gtr/tests?term=C0431109%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (27)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0431109%5bDISCUI%5d" target="_blank">See all (27)</a></total></li>
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