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<meta name="keywords" content="C0425772, finding, precocious breast development, precocious thelarche, premature breast development, premature breast development at puberty, premature development of the breasts, premature thelarche, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Premature development of the breasts." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=98416
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ConceptID=C0425772
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Premature thelarche</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98416</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0425772</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Precocious breast development; Precocious thelarche; Premature breast development; Premature breast development at puberty; Premature development of the breasts; Premature Thelarche</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Premature breast development at puberty (102889008); Premature development of the breasts (102889008); Precocious breast development (102889008); Precocious thelarche (102889008); Premature breast development (102889008)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0010314">HP:0010314</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Premature development of the breasts. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Premature thelarche</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/272632" ref="tree=MeSH" title="MedGen record for Finding by Site or System">Finding by Site or System</a></span><ul><li><span class="TLline"><a href="/medgen/277594" ref="tree=MeSH" title="MedGen record for Reproductive System Finding">Reproductive System Finding</a></span><ul><li><span class="TLline"><a href="/medgen/858736" ref="tree=MeSH" title="MedGen record for Female Reproductive System Finding">Female Reproductive System Finding</a></span><ul><li><span class="matched_ds">Premature thelarche</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_162897"><div><strong>Kabuki syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>162897</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0796004</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Kabuki syndrome (KS) is characterized by typical facial features (long palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows; short columella with depressed nasal tip; large, prominent, or cupped ears), minor skeletal anomalies, persistence of fetal fingertip pads, mild-to-moderate intellectual disability, and postnatal growth deficiency. Other findings may include: congenital heart defects, genitourinary anomalies, cleft lip and/or palate, gastrointestinal anomalies including anal atresia, ptosis and strabismus, and widely spaced teeth and hypodontia. Functional differences can include: increased susceptibility to infections and autoimmune disorders, seizures, endocrinologic abnormalities (including isolated premature thelarche in females), feeding problems, and hearing loss.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/162897">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_815529"><div><strong>Precocious puberty, central, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815529</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809199</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty, which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. The timing of puberty is associated with risks of subsequent disease: earlier age of menarche in girls is associated with increased risk of breast cancer, endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Central precocious puberty has also been associated with an increased incidence of conduct and behavior disorders during adolescence (summary by Abreu et al., 2013). For discussion of genetic heterogeneity of central precocious puberty, see CPPB1 (176400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/815529">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1639327"><div><strong>Rubinstein-Taybi syndrome due to CREBBP mutations</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1639327</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Rubinstein-Taybi syndrome (RSTS) is characterized by distinctive facial features, broad and often angulated thumbs and halluces, short stature, and moderate-to-severe intellectual disability. Characteristic craniofacial features include downslanted palpebral fissures, low-hanging columella, high palate, grimacing smile, and talon cusps. Prenatal growth is often normal, then height, weight, and head circumference percentiles rapidly drop in the first few months of life. Short stature is typical in adulthood. Obesity may develop in childhood or adolescence. Average IQ ranges between 35 and 50; however, developmental outcome varies considerably. Some individuals with EP300-related RSTS have normal intellect. Additional features include ocular abnormalities, hearing loss, respiratory difficulties, congenital heart defects, renal abnormalities, cryptorchidism, feeding problems, recurrent infections, and severe constipation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1639327">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1782083"><div><strong>Faundes-Banka syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1782083</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543554</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Faundes-Banka syndrome (FABAS) is an autosomal dominant disorder characterized by variable combinations of developmental delay and microcephaly, as well as micrognathia and other dysmorphic features (Faundes et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1782083">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1798947"><div><strong>Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1798947</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5567524</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">TANGO2 deficiency is characterized by developmental delay, intellectual disability, gait incoordination, speech difficulties, seizures, and hypothyroidism. Most individuals have TANGO2 spells, non-life-threatening paroxysmal worsening of baseline symptoms, including sudden onset of hypotonia, ataxia with loss of balance, head and body tilt, increased dysarthria, drooling, lethargy, and disorientation. In addition, life-threatening acute metabolic crises can occur, including rhabdomyolysis with elevated creatine phosphokinase and liver transaminases, hypoglycemia, prolonged QTc on EKG, ventricular arrhythmias, and/or cardiomyopathy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1798947">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1782083" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Faundes-Banka syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_162897" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kabuki syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_815529" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Precocious puberty, central, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1798947" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1639327" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rubinstein-Taybi syndrome due to CREBBP mutations</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/21274291">Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Berberoğlu M</span><br />
|
||
<span class="medgenPMjournal">J Clin Res Pediatr Endocrinol</span>
|
||
2009;1(4):164-74.
|
||
Epub 2009 May 2
|
||
doi: 10.4274/jcrpe.v1i4.3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21274291" target="_blank">21274291</a><a href="/pmc/articles/PMC3005651" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18367996">Premature thelarche from phenotype to genotype.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Codner E,
|
||
Román R</span><br />
|
||
<span class="medgenPMjournal">Pediatr Endocrinol Rev</span>
|
||
2008 Mar;5(3):760-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18367996" target="_blank">18367996</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10969928">Premature thelarche: clinical follow-up and indication for treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stanhope R</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Endocrinol Metab</span>
|
||
2000 Jul;13 Suppl 1:827-30.
|
||
doi: 10.1515/jpem.2000.13.s1.827.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10969928" target="_blank">10969928</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22premature%20thelarche%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (12)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38107513">Prevalence and characteristics of thelarche variant.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Burlo F,
|
||
Lorenzon B,
|
||
Tamaro G,
|
||
Fabretto A,
|
||
Buonomo F,
|
||
Peinkhofer M,
|
||
Vidonis V,
|
||
Vittori G,
|
||
Faleschini E,
|
||
Barbi E,
|
||
Tornese G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1303989.
|
||
Epub 2023 Dec 1
|
||
doi: 10.3389/fendo.2023.1303989.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38107513" target="_blank">38107513</a><a href="/pmc/articles/PMC10722224" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34539579">Diagnostic Accuracy of Female Pelvic Ultrasonography in Differentiating Precocious Puberty From Premature Thelarche: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nguyen NN,
|
||
Huynh LBP,
|
||
Do MD,
|
||
Yang TY,
|
||
Tsai MC,
|
||
Chen YC</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:735875.
|
||
Epub 2021 Sep 1
|
||
doi: 10.3389/fendo.2021.735875.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34539579" target="_blank">34539579</a><a href="/pmc/articles/PMC8442957" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29625387">Urinary phthalate metabolite concentrations in girls with premature thelarche.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Durmaz E,
|
||
Erkekoglu P,
|
||
Asci A,
|
||
Akçurin S,
|
||
Bircan İ,
|
||
Kocer-Gumusel B</span><br />
|
||
<span class="medgenPMjournal">Environ Toxicol Pharmacol</span>
|
||
2018 Apr;59:172-181.
|
||
Epub 2018 Mar 17
|
||
doi: 10.1016/j.etap.2018.03.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29625387" target="_blank">29625387</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10969928">Premature thelarche: clinical follow-up and indication for treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stanhope R</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Endocrinol Metab</span>
|
||
2000 Jul;13 Suppl 1:827-30.
|
||
doi: 10.1515/jpem.2000.13.s1.827.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10969928" target="_blank">10969928</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4091585">Premature thelarche: a follow up study of 40 girls. Natural history and endocrine findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pasquino AM,
|
||
Tebaldi L,
|
||
Cioschi L,
|
||
Cives C,
|
||
Finocchi G,
|
||
Maciocci M,
|
||
Mancuso G,
|
||
Boscherini B</span><br />
|
||
<span class="medgenPMjournal">Arch Dis Child</span>
|
||
1985 Dec;60(12):1180-2.
|
||
doi: 10.1136/adc.60.12.1180.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4091585" target="_blank">4091585</a><a href="/pmc/articles/PMC1777679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20thelarche%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (125)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32423709">Disorders of Pubertal Onset.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Elchuri SV,
|
||
Momen JJ</span><br />
|
||
<span class="medgenPMjournal">Prim Care</span>
|
||
2020 Jun;47(2):189-216.
|
||
Epub 2020 Feb 12
|
||
doi: 10.1016/j.pop.2020.02.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32423709" target="_blank">32423709</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29422239">Disorders of puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sultan C,
|
||
Gaspari L,
|
||
Maimoun L,
|
||
Kalfa N,
|
||
Paris F</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
|
||
2018 Apr;48:62-89.
|
||
Epub 2017 Nov 14
|
||
doi: 10.1016/j.bpobgyn.2017.11.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29422239" target="_blank">29422239</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29323691">Premature Thelarche.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khokhar A,
|
||
Mojica A</span><br />
|
||
<span class="medgenPMjournal">Pediatr Ann</span>
|
||
2018 Jan 1;47(1):e12-e15.
|
||
doi: 10.3928/19382359-20171214-01.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29323691" target="_blank">29323691</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21274291">Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Berberoğlu M</span><br />
|
||
<span class="medgenPMjournal">J Clin Res Pediatr Endocrinol</span>
|
||
2009;1(4):164-74.
|
||
Epub 2009 May 2
|
||
doi: 10.4274/jcrpe.v1i4.3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21274291" target="_blank">21274291</a><a href="/pmc/articles/PMC3005651" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2671495">Premature thelarche.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leung AK</span><br />
|
||
<span class="medgenPMjournal">J Singapore Paediatr Soc</span>
|
||
1989;31(1-2):64-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2671495" target="_blank">2671495</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20thelarche%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (159)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/24840046">Premature thelarche in an 8-year-old girl following prolonged use of risperidone.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">White AM,
|
||
Singh R,
|
||
Rais T,
|
||
Coffey BJ</span><br />
|
||
<span class="medgenPMjournal">J Child Adolesc Psychopharmacol</span>
|
||
2014 May;24(4):228-30.
|
||
doi: 10.1089/cap.2014.2442.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24840046" target="_blank">24840046</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22099730">Premature thelarche in infants and toddlers: prevalence, natural history and environmental determinants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Curfman AL,
|
||
Reljanovic SM,
|
||
McNelis KM,
|
||
Dong TT,
|
||
Lewis SA,
|
||
Jackson LW,
|
||
Cromer BA</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Adolesc Gynecol</span>
|
||
2011 Dec;24(6):338-41.
|
||
doi: 10.1016/j.jpag.2011.01.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22099730" target="_blank">22099730</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9174689">Premature thelarche and precocious puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Quigley CA,
|
||
Pescovitz OH</span><br />
|
||
<span class="medgenPMjournal">Curr Ther Endocrinol Metab</span>
|
||
1997;6:7-13.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9174689" target="_blank">9174689</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6958274">Premature thelarche and ovarian cyst probably secondary to estrogen contamination.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sáenz CA,
|
||
Toro-Solá M,
|
||
Conde L,
|
||
Bayonet-Rivera NP</span><br />
|
||
<span class="medgenPMjournal">Bol Asoc Med P R</span>
|
||
1982 Feb;74(2):16-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6958274" target="_blank">6958274</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/5808532">Radioimmunoassayable serum LH and FSH in girls with sexual precocity, premature thelarche and adrenarche.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kenny FM,
|
||
Midgley AR Jr,
|
||
Jaffe RB,
|
||
Garces LY,
|
||
Vazquez A,
|
||
Taylor FH</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
1969 Sep;29(9):1272-5.
|
||
doi: 10.1210/jcem-29-9-1272.
|
||
<span class="bold">PMID: </span><a href="/pubmed/5808532" target="_blank">5808532</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20thelarche%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (51)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39427109">Serum phoenixin levels in girls with central precocious puberty and premature thelarche.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Qin Y,
|
||
Deng H,
|
||
Liu L,
|
||
Li M,
|
||
Yang J,
|
||
Zhang C,
|
||
Zhou J,
|
||
Xiao Y</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2025 Feb;87(2):857-865.
|
||
Epub 2024 Oct 20
|
||
doi: 10.1007/s12020-024-04074-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39427109" target="_blank">39427109</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38397440">Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sharma K,
|
||
Lanzilotto A,
|
||
Yakubu J,
|
||
Therkelsen S,
|
||
Vöegel CD,
|
||
Du Toit T,
|
||
Jørgensen FS,
|
||
Pandey AV</span><br />
|
||
<span class="medgenPMjournal">Biomolecules</span>
|
||
2024 Feb 8;14(2)
|
||
doi: 10.3390/biom14020203.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38397440" target="_blank">38397440</a><a href="/pmc/articles/PMC10887332" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29323691">Premature Thelarche.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khokhar A,
|
||
Mojica A</span><br />
|
||
<span class="medgenPMjournal">Pediatr Ann</span>
|
||
2018 Jan 1;47(1):e12-e15.
|
||
doi: 10.3928/19382359-20171214-01.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29323691" target="_blank">29323691</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10969928">Premature thelarche: clinical follow-up and indication for treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stanhope R</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Endocrinol Metab</span>
|
||
2000 Jul;13 Suppl 1:827-30.
|
||
doi: 10.1515/jpem.2000.13.s1.827.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10969928" target="_blank">10969928</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4091585">Premature thelarche: a follow up study of 40 girls. Natural history and endocrine findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pasquino AM,
|
||
Tebaldi L,
|
||
Cioschi L,
|
||
Cives C,
|
||
Finocchi G,
|
||
Maciocci M,
|
||
Mancuso G,
|
||
Boscherini B</span><br />
|
||
<span class="medgenPMjournal">Arch Dis Child</span>
|
||
1985 Dec;60(12):1180-2.
|
||
doi: 10.1136/adc.60.12.1180.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4091585" target="_blank">4091585</a><a href="/pmc/articles/PMC1777679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20thelarche%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (60)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39427109">Serum phoenixin levels in girls with central precocious puberty and premature thelarche.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Qin Y,
|
||
Deng H,
|
||
Liu L,
|
||
Li M,
|
||
Yang J,
|
||
Zhang C,
|
||
Zhou J,
|
||
Xiao Y</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2025 Feb;87(2):857-865.
|
||
Epub 2024 Oct 20
|
||
doi: 10.1007/s12020-024-04074-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39427109" target="_blank">39427109</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38397440">Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sharma K,
|
||
Lanzilotto A,
|
||
Yakubu J,
|
||
Therkelsen S,
|
||
Vöegel CD,
|
||
Du Toit T,
|
||
Jørgensen FS,
|
||
Pandey AV</span><br />
|
||
<span class="medgenPMjournal">Biomolecules</span>
|
||
2024 Feb 8;14(2)
|
||
doi: 10.3390/biom14020203.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38397440" target="_blank">38397440</a><a href="/pmc/articles/PMC10887332" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37496240">Premature Thelarche: An Updated Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leung AKC,
|
||
Lam JM,
|
||
Hon KL</span><br />
|
||
<span class="medgenPMjournal">Curr Pediatr Rev</span>
|
||
2024;20(4):500-509.
|
||
doi: 10.2174/1573396320666230726110658.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37496240" target="_blank">37496240</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35000523">Oxidant-antioxidant balance in girls with precocious puberty: a case-control study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Köksal T,
|
||
Yalçin SS,
|
||
Uçartürk SA</span><br />
|
||
<span class="medgenPMjournal">Int J Environ Health Res</span>
|
||
2023 Mar;33(3):299-306.
|
||
Epub 2022 Jan 10
|
||
doi: 10.1080/09603123.2022.2025767.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35000523" target="_blank">35000523</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35764868">Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Almasi N,
|
||
Zengin HY,
|
||
Koç N,
|
||
Uçakturk SA,
|
||
İskender Mazman D,
|
||
Heidarzadeh Rad N,
|
||
Fisunoglu M</span><br />
|
||
<span class="medgenPMjournal">J Endocrinol Invest</span>
|
||
2022 Nov;45(11):2097-2103.
|
||
Epub 2022 Jun 28
|
||
doi: 10.1007/s40618-022-01841-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35764868" target="_blank">35764868</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20thelarche%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (77)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37996919">Dose inhibin B or anti-Müllerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang M,
|
||
Gao Y,
|
||
Qu T,
|
||
Ji Y,
|
||
Niu Y,
|
||
Zhang J,
|
||
Huang L</span><br />
|
||
<span class="medgenPMjournal">J Ovarian Res</span>
|
||
2023 Nov 23;16(1):227.
|
||
doi: 10.1186/s13048-023-01302-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37996919" target="_blank">37996919</a><a href="/pmc/articles/PMC10668349" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34539579">Diagnostic Accuracy of Female Pelvic Ultrasonography in Differentiating Precocious Puberty From Premature Thelarche: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nguyen NN,
|
||
Huynh LBP,
|
||
Do MD,
|
||
Yang TY,
|
||
Tsai MC,
|
||
Chen YC</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:735875.
|
||
Epub 2021 Sep 1
|
||
doi: 10.3389/fendo.2021.735875.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34539579" target="_blank">34539579</a><a href="/pmc/articles/PMC8442957" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32147050">The relationship between lavender and tea tree essential oils and pediatric endocrine disorders: A systematic review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hawkins J,
|
||
Hires C,
|
||
Dunne E,
|
||
Baker C</span><br />
|
||
<span class="medgenPMjournal">Complement Ther Med</span>
|
||
2020 Mar;49:102288.
|
||
Epub 2019 Dec 20
|
||
doi: 10.1016/j.ctim.2019.102288.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32147050" target="_blank">32147050</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20thelarche%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
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|
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|
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|
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<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Premature%20thelarche" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22premature%20thelarche%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Premature%20thelarche" target="_blank">MedlinePlus</a></li></ul></div>
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<a href="/pubmed/clinical?term=Premature%20thelarche" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Premature%20thelarche%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=98416" ref="log$=recordlinks">ClinVar</a>
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<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=98416" ref="log$=recordlinks">PMC Articles</a>
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d0b7e0f4a390645ecc4932">Premature thelarche</a>
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<div class="ralinkpop offscreen_noflow">Premature thelarche<div class="brieflinkpopdesc"></div></div>
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<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d0b7def4a390645ecc42d6">C0425772[conceptid] <span class="number">(1)</span></a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d0b7dda68b6b5afc04a9f0">C4021601[trait identifier] AND "Talkowski Laboratory, Center for ... <span class="number">(1)</span></a>
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<div class="ralinkpop offscreen_noflow">C4021601[trait identifier] AND "Talkowski Laboratory, Center for Human Genetic Research, Massachusetts General Hospital"[submitter]<div class="brieflinkpopdesc">Search</div></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d0b7dca68b6b5afc04a6a6">Premature eruption of permanent teeth</a>
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