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<meta name="keywords" content="C0345967, bcl10, cancer, mesothelioma, malignant mesothelial neoplasm, malignant mesothelial tumor, malignant mesothelial tumour, malignant mesothelioma, malignant mesothelioma (disease), malignant mesotheliomas, malignant neoplasm of mesothelium, malignant neoplasm of the mesothelium, malignant tumor of mesothelium, malignant tumor of the mesothelium, malignant tumour of mesothelium, malignant tumour of the mesothelium, mesom, mesothelioma (malignant, clinical disorder), mesothelioma, malignant, mesothelioma, somatic, mesotheliomas, malignant, neoplastic process, pleural mesothelioma, wt1, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=91062
|
||
ConceptID=C0345967
|
||
-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Mesothelioma, malignant<span class="h1sub">(MESOM)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>91062</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0345967</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Malignant mesothelioma (disease); MESOM</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Mesothelioma, malignant (62064005); Malignant mesothelioma (62064005); Mesothelioma (malignant, clinical disorder) (109378008); Malignant mesothelioma (109378008); Cancer, mesothelioma (109378008)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="BCL10 - ID: 8915 - NCBI Gene" href="/gene/8915" class="medgenPMinfo">BCL10</a> (1p22.3); <a target="_blank" title="WT1 - ID: 7490 - NCBI Gene" href="/gene/7490" class="medgenPMinfo">WT1</a> (11p13)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100001">HP:0100001</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0006292" target="_blank">MONDO:0006292</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/156240" target="_blank">156240</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=50251">ORPHA50251</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21. [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_91062"><div><strong>Mesothelioma, malignant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>91062</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0345967</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/91062">Feature record</a> | <a href="/medgen?term=%22Mesothelioma%2C%20malignant%22%5BClinical%20Features%5D%20OR%2091062%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_91062" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mesothelioma, malignant</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0345967[DISCUI]&test_type=Clinical" ref="ncbi_uid=91062">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=91062" target="_blank" href="/omim/156240">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=91062" ref="ncbi_uid=91062">V</a></span></span><span class="TLline">Mesothelioma, malignant</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1863470" ref="tree=MeSH" title="MedGen record for Bronchopulmonary tumor">Bronchopulmonary tumor</a></span><ul><li><span class="matched_ds">Mesothelioma, malignant</span><ul><li><span class="TLline"><a href="/medgen/233996" ref="tree=MeSH" title="MedGen record for Asbestos-Related Malignant Mesothelioma">Asbestos-Related Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/97895" ref="tree=MeSH" title="MedGen record for Diffuse Malignant Mesothelioma">Diffuse Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/220861" ref="tree=MeSH" title="MedGen record for Desmoplastic Mesothelioma">Desmoplastic Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/311131" ref="tree=MeSH" title="MedGen record for Pleural Desmoplastic Mesothelioma">Pleural Desmoplastic Mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/137775" ref="tree=MeSH" title="MedGen record for Malignant biphasic mesothelioma">Malignant biphasic mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/1727632" ref="tree=MeSH" title="MedGen record for Paratesticular Biphasic Mesothelioma">Paratesticular Biphasic Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1716484" ref="tree=MeSH" title="MedGen record for Peritoneal Biphasic Mesothelioma">Peritoneal Biphasic Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/311130" ref="tree=MeSH" title="MedGen record for Pleural biphasic mesothelioma">Pleural biphasic mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163578" ref="tree=MeSH" title="MedGen record for Malignant epithelioid mesothelioma">Malignant epithelioid mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/1787209" ref="tree=MeSH" title="MedGen record for Advanced Epithelioid Mesothelioma">Advanced Epithelioid Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1772142" ref="tree=MeSH" title="MedGen record for Paratesticular Epithelioid Mesothelioma">Paratesticular Epithelioid Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1686833" ref="tree=MeSH" title="MedGen record for Peritoneal Epithelioid Mesothelioma">Peritoneal Epithelioid Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/318031" ref="tree=MeSH" title="MedGen record for Pleural epithelioid mesothelioma">Pleural epithelioid mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1782245" ref="tree=MeSH" title="MedGen record for Recurrent Epithelioid Mesothelioma">Recurrent Epithelioid Mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/137774" ref="tree=MeSH" title="MedGen record for Sarcomatoid mesothelioma">Sarcomatoid mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/235269" ref="tree=MeSH" title="MedGen record for Lymphohistiocytoid mesothelioma">Lymphohistiocytoid mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1729442" ref="tree=MeSH" title="MedGen record for Paratesticular Sarcomatoid Mesothelioma">Paratesticular Sarcomatoid Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1714288" ref="tree=MeSH" title="MedGen record for Peritoneal Sarcomatoid Mesothelioma">Peritoneal Sarcomatoid Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/354059" ref="tree=MeSH" title="MedGen record for Pleural sarcomatoid mesothelioma">Pleural sarcomatoid mesothelioma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/75866" ref="tree=MeSH" title="MedGen record for Localized Malignant Mesothelioma">Localized Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/163481" ref="tree=MeSH" title="MedGen record for Localized Pleural Malignant Mesothelioma">Localized Pleural Malignant Mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83406" ref="tree=MeSH" title="MedGen record for Malignant peritoneal mesothelioma">Malignant peritoneal mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/1794005" ref="tree=MeSH" title="MedGen record for Metastatic Peritoneal Malignant Mesothelioma">Metastatic Peritoneal Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/163160" ref="tree=MeSH" title="MedGen record for Advanced Peritoneal Malignant Mesothelioma">Advanced Peritoneal Malignant Mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163480" ref="tree=MeSH" title="MedGen record for Recurrent Peritoneal Malignant Mesothelioma">Recurrent Peritoneal Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1721540" ref="tree=MeSH" title="MedGen record for Unresectable Peritoneal Malignant Mesothelioma">Unresectable Peritoneal Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/1738910" ref="tree=MeSH" title="MedGen record for Unresectable Peritoneal Biphasic Mesothelioma">Unresectable Peritoneal Biphasic Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1732936" ref="tree=MeSH" title="MedGen record for Unresectable Peritoneal Epithelioid Mesothelioma">Unresectable Peritoneal Epithelioid Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1770192" ref="tree=MeSH" title="MedGen record for Unresectable Peritoneal Sarcomatoid Mesothelioma">Unresectable Peritoneal Sarcomatoid Mesothelioma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/208810" ref="tree=MeSH" title="MedGen record for Malignant pleural mesothelioma">Malignant pleural mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/1719176" ref="tree=MeSH" title="MedGen record for Metastatic Pleural Malignant Mesothelioma">Metastatic Pleural Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/208925" ref="tree=MeSH" title="MedGen record for Advanced Pleural Malignant Mesothelioma">Advanced Pleural Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1787338" ref="tree=MeSH" title="MedGen record for Locally Advanced Pleural Malignant Mesothelioma">Locally Advanced Pleural Malignant Mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1616945" ref="tree=MeSH" title="MedGen record for Pleural Malignant Mesothelioma by AJCC v7 Stage">Pleural Malignant Mesothelioma by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/277763" ref="tree=MeSH" title="MedGen record for Stage I Pleural Malignant Mesothelioma AJCC v7">Stage I Pleural Malignant Mesothelioma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/233511" ref="tree=MeSH" title="MedGen record for Stage II Pleural Malignant Mesothelioma AJCC v7">Stage II Pleural Malignant Mesothelioma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/234848" ref="tree=MeSH" title="MedGen record for Stage III Pleural Malignant Mesothelioma AJCC v7">Stage III Pleural Malignant Mesothelioma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/236941" ref="tree=MeSH" title="MedGen record for Stage IV Pleural Malignant Mesothelioma AJCC v7">Stage IV Pleural Malignant Mesothelioma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1623654" ref="tree=MeSH" title="MedGen record for Pleural Malignant Mesothelioma by AJCC v8 Stage">Pleural Malignant Mesothelioma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1613880" ref="tree=MeSH" title="MedGen record for Stage I Pleural Malignant Mesothelioma AJCC v8">Stage I Pleural Malignant Mesothelioma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1622769" ref="tree=MeSH" title="MedGen record for Stage II Pleural Malignant Mesothelioma AJCC v8">Stage II Pleural Malignant Mesothelioma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1623294" ref="tree=MeSH" title="MedGen record for Stage III Pleural Malignant Mesothelioma AJCC v8">Stage III Pleural Malignant Mesothelioma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1622540" ref="tree=MeSH" title="MedGen record for Stage IV Pleural Malignant Mesothelioma AJCC v8">Stage IV Pleural Malignant Mesothelioma AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163482" ref="tree=MeSH" title="MedGen record for Recurrent Pleural Malignant Mesothelioma">Recurrent Pleural Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1686266" ref="tree=MeSH" title="MedGen record for Refractory Pleural Malignant Mesothelioma">Refractory Pleural Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1653062" ref="tree=MeSH" title="MedGen record for Resectable Pleural Malignant Mesothelioma">Resectable Pleural Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1661826" ref="tree=MeSH" title="MedGen record for Unresectable Pleural Malignant Mesothelioma">Unresectable Pleural Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/1725513" ref="tree=MeSH" title="MedGen record for Unresectable Pleural Biphasic Mesothelioma">Unresectable Pleural Biphasic Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1749247" ref="tree=MeSH" title="MedGen record for Unresectable Pleural Epithelioid Mesothelioma">Unresectable Pleural Epithelioid Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1775056" ref="tree=MeSH" title="MedGen record for Unresectable Pleural Sarcomatoid Mesothelioma">Unresectable Pleural Sarcomatoid Mesothelioma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1720326" ref="tree=MeSH" title="MedGen record for Metastatic Malignant Mesothelioma">Metastatic Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/82976" ref="tree=MeSH" title="MedGen record for Advanced Malignant Mesothelioma">Advanced Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/208924" ref="tree=MeSH" title="MedGen record for Advanced Pericardial Malignant Mesothelioma">Advanced Pericardial Malignant Mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1780272" ref="tree=MeSH" title="MedGen record for Locally Advanced Malignant Mesothelioma">Locally Advanced Malignant Mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/274089" ref="tree=MeSH" title="MedGen record for Ovarian malignant mesothelioma">Ovarian malignant mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/782172" ref="tree=MeSH" title="MedGen record for Paratesticular Malignant Mesothelioma">Paratesticular Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/1738205" ref="tree=MeSH" title="MedGen record for Unresectable Paratesticular Malignant Mesothelioma">Unresectable Paratesticular Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/1770540" ref="tree=MeSH" title="MedGen record for Unresectable Paratesticular Biphasic Mesothelioma">Unresectable Paratesticular Biphasic Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1728639" ref="tree=MeSH" title="MedGen record for Unresectable Paratesticular Epithelioid Mesothelioma">Unresectable Paratesticular Epithelioid Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1733317" ref="tree=MeSH" title="MedGen record for Unresectable Paratesticular Sarcomatoid Mesothelioma">Unresectable Paratesticular Sarcomatoid Mesothelioma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/83407" ref="tree=MeSH" title="MedGen record for Pericardial Malignant Mesothelioma">Pericardial Malignant Mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/167730" ref="tree=MeSH" title="MedGen record for Recurrent Pericardial Malignant Mesothelioma">Recurrent Pericardial Malignant Mesothelioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233322" ref="tree=MeSH" title="MedGen record for Pericardial mesothelioma">Pericardial mesothelioma</a></span><ul><li><span class="TLline"><a href="/medgen/457129" ref="tree=MeSH" title="MedGen record for Pericardial Adenomatoid Tumor">Pericardial Adenomatoid Tumor</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75867" ref="tree=MeSH" title="MedGen record for Recurrent Malignant Mesothelioma">Recurrent Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1659783" ref="tree=MeSH" title="MedGen record for Refractory Malignant Mesothelioma">Refractory Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1650647" ref="tree=MeSH" title="MedGen record for Resectable Malignant Mesothelioma">Resectable Malignant Mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/868000" ref="tree=MeSH" title="MedGen record for Testicular mesothelioma">Testicular mesothelioma</a></span></li><li><span class="TLline"><a href="/medgen/1662411" ref="tree=MeSH" title="MedGen record for Unresectable Malignant Mesothelioma">Unresectable Malignant Mesothelioma</a></span></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_91062"><div><strong>Mesothelioma, malignant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>91062</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0345967</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/91062">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_482122"><div><strong>BAP1-related tumor predisposition syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482122</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for a specific skin lesion, BAP1-inactivated melanocytic tumors (BIMT; formerly called atypical Spitz tumors), and the following cancers, in descending order of frequency: uveal (eye) melanoma (UM), malignant mesothelioma (MMe), cutaneous melanoma (CM), renal cell carcinoma (RCC), basal cell carcinoma (BCC), meningioma, and cholangiocarcinoma. Onychopapillomas, hepatocellular carcinoma, and ovarian sex cord-stromal tumors may also be associated with BAP1-TPDS. Affected individuals can have more than one type of primary cancer. In general, the median age of onset of these tumors is younger than in the general population. UM tends to be a more aggressive class 2 tumor with higher risk for metastasis and reduced survival compared to UM occurring in the general population. RCC is usually of clear cell morphology, but other pathologies have been reported. MMe, especially pleural, has better survival and responds better to platinum chemotherapy than MMe not associated with a germline BAP1 pathogenic variant. The penetrance, natural history, life-time cancer risk for carriers, and frequencies of BAP1-associated tumors are yet to be fully determined.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/482122">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482122" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">BAP1-related tumor predisposition syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_91062" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mesothelioma, malignant</a></div></div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/31443309">Malignant Pleural Effusion and Its Current Management: A Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Skok K,
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Hladnik G,
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Grm A,
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Crnjac A</span><br />
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<span class="medgenPMjournal">Medicina (Kaunas)</span>
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2019 Aug 15;55(8)
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doi: 10.3390/medicina55080490.
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<span class="bold">PMID: </span><a href="/pubmed/31443309" target="_blank">31443309</a><a href="/pmc/articles/PMC6723530" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28686500">Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Husain AN,
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Colby TV,
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Ordóñez NG,
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Allen TC,
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Attanoos RL,
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Beasley MB,
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Butnor KJ,
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Chirieac LR,
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Churg AM,
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Dacic S,
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Galateau-Sallé F,
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Gibbs A,
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Gown AM,
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Krausz T,
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Litzky LA,
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Marchevsky A,
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Nicholson AG,
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Roggli VL,
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Sharma AK,
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Travis WD,
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Walts AE,
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Wick MR</span><br />
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<span class="medgenPMjournal">Arch Pathol Lab Med</span>
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2018 Jan;142(1):89-108.
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Epub 2017 Jul 7
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doi: 10.5858/arpa.2017-0124-RA.
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<span class="bold">PMID: </span><a href="/pubmed/28686500" target="_blank">28686500</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/11355969">Malignant mesothelioma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ruffié P,
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Lehmann M,
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Galateau-Sallé F,
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Lagrange JL,
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Pairon JC;
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French National Federation of Cancer (FNCLCC)</span><br />
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<span class="medgenPMjournal">Br J Cancer</span>
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2001 May;84 Suppl 2(Suppl 2):49-50.
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doi: 10.1054/bjoc.2001.1763.
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<span class="bold">PMID: </span><a href="/pubmed/11355969" target="_blank">11355969</a><a href="/pmc/articles/PMC2408846" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22mesothelioma%2C%20malignant%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (207)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36630203">Asbestos-associated pulmonary disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caceres JD,
|
||
Venkata AN</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Pulm Med</span>
|
||
2023 Mar 1;29(2):76-82.
|
||
Epub 2023 Jan 11
|
||
doi: 10.1097/MCP.0000000000000939.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36630203" target="_blank">36630203</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35940275">Malignant peritoneal mesothelioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chun CP,
|
||
Song LX,
|
||
Zhang HP,
|
||
Guo DD,
|
||
Xu GX,
|
||
Li Y,
|
||
Xin X,
|
||
Cao J,
|
||
Li F</span><br />
|
||
<span class="medgenPMjournal">Am J Med Sci</span>
|
||
2023 Jan;365(1):99-103.
|
||
Epub 2022 Aug 6
|
||
doi: 10.1016/j.amjms.2022.07.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35940275" target="_blank">35940275</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34861373">Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Popat S,
|
||
Baas P,
|
||
Faivre-Finn C,
|
||
Girard N,
|
||
Nicholson AG,
|
||
Nowak AK,
|
||
Opitz I,
|
||
Scherpereel A,
|
||
Reck M;
|
||
ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2022 Feb;33(2):129-142.
|
||
Epub 2021 Nov 30
|
||
doi: 10.1016/j.annonc.2021.11.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34861373" target="_blank">34861373</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34465883">Pleural mesothelioma classification-update and challenges.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dacic S</span><br />
|
||
<span class="medgenPMjournal">Mod Pathol</span>
|
||
2022 Jan;35(Suppl 1):51-56.
|
||
Epub 2021 Aug 31
|
||
doi: 10.1038/s41379-021-00895-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34465883" target="_blank">34465883</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33186182">Malignant pleural mesothelioma: recent developments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sinn K,
|
||
Mosleh B,
|
||
Hoda MA</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Oncol</span>
|
||
2021 Jan;33(1):80-86.
|
||
doi: 10.1097/CCO.0000000000000697.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33186182" target="_blank">33186182</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesothelioma%2C%20malignant%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1154)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37461124">Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang Q,
|
||
Xu C,
|
||
Wang W,
|
||
Zhang Y,
|
||
Li Z,
|
||
Song Z,
|
||
Wang J,
|
||
Yu J,
|
||
Liu J,
|
||
Zhang S,
|
||
Cai X,
|
||
Li W,
|
||
Zhan P,
|
||
Liu H,
|
||
Lv T,
|
||
Miao L,
|
||
Min L,
|
||
Li J,
|
||
Liu B,
|
||
Yuan J,
|
||
Jiang Z,
|
||
Lin G,
|
||
Chen X,
|
||
Pu X,
|
||
Rao C,
|
||
Lv D,
|
||
Yu Z,
|
||
Li X,
|
||
Tang C,
|
||
Zhou C,
|
||
Zhang J,
|
||
Guo H,
|
||
Chu Q,
|
||
Meng R,
|
||
Liu X,
|
||
Wu J,
|
||
Hu X,
|
||
Zhou J,
|
||
Zhu Z,
|
||
Chen X,
|
||
Pan W,
|
||
Pang F,
|
||
Zhang W,
|
||
Jian Q,
|
||
Wang K,
|
||
Wang L,
|
||
Zhu Y,
|
||
Yang G,
|
||
Lin X,
|
||
Cai J,
|
||
Feng H,
|
||
Wang L,
|
||
Du Y,
|
||
Yao W,
|
||
Shi X,
|
||
Niu X,
|
||
Yuan D,
|
||
Yao Y,
|
||
Huang J,
|
||
Wang X,
|
||
Zhang Y,
|
||
Sun P,
|
||
Wang H,
|
||
Ye M,
|
||
Wang D,
|
||
Wang Z,
|
||
Hao Y,
|
||
Wang Z,
|
||
Wan B,
|
||
Lv D,
|
||
Yu J,
|
||
Kang J,
|
||
Zhang J,
|
||
Zhang C,
|
||
Wu L,
|
||
Shi L,
|
||
Ye L,
|
||
Wang G,
|
||
Wang Y,
|
||
Gao F,
|
||
Huang J,
|
||
Wang G,
|
||
Wei J,
|
||
Huang L,
|
||
Li B,
|
||
Zhang Z,
|
||
Li Z,
|
||
Liu Y,
|
||
Li Y,
|
||
Liu Z,
|
||
Yang N,
|
||
Wu L,
|
||
Wang Q,
|
||
Huang W,
|
||
Hong Z,
|
||
Wang G,
|
||
Qu F,
|
||
Fang M,
|
||
Fang Y,
|
||
Zhu X,
|
||
Du K,
|
||
Ji J,
|
||
Shen Y,
|
||
Chen J,
|
||
Zhang Y,
|
||
Ma S,
|
||
Lu Y,
|
||
Song Y,
|
||
Liu A,
|
||
Zhong W,
|
||
Fang W</span><br />
|
||
<span class="medgenPMjournal">Thorac Cancer</span>
|
||
2023 Sep;14(26):2715-2731.
|
||
Epub 2023 Jul 17
|
||
doi: 10.1111/1759-7714.15022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37461124" target="_blank">37461124</a><a href="/pmc/articles/PMC10493492" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35940275">Malignant peritoneal mesothelioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chun CP,
|
||
Song LX,
|
||
Zhang HP,
|
||
Guo DD,
|
||
Xu GX,
|
||
Li Y,
|
||
Xin X,
|
||
Cao J,
|
||
Li F</span><br />
|
||
<span class="medgenPMjournal">Am J Med Sci</span>
|
||
2023 Jan;365(1):99-103.
|
||
Epub 2022 Aug 6
|
||
doi: 10.1016/j.amjms.2022.07.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35940275" target="_blank">35940275</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34465883">Pleural mesothelioma classification-update and challenges.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dacic S</span><br />
|
||
<span class="medgenPMjournal">Mod Pathol</span>
|
||
2022 Jan;35(Suppl 1):51-56.
|
||
Epub 2021 Aug 31
|
||
doi: 10.1038/s41379-021-00895-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34465883" target="_blank">34465883</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34551230">Perspectives on the Treatment of Malignant Pleural Mesothelioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Janes SM,
|
||
Alrifai D,
|
||
Fennell DA</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2021 Sep 23;385(13):1207-1218.
|
||
doi: 10.1056/NEJMra1912719.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34551230" target="_blank">34551230</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33186182">Malignant pleural mesothelioma: recent developments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sinn K,
|
||
Mosleh B,
|
||
Hoda MA</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Oncol</span>
|
||
2021 Jan;33(1):80-86.
|
||
doi: 10.1097/CCO.0000000000000697.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33186182" target="_blank">33186182</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesothelioma%2C%20malignant%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1481)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34985934">New Era for Malignant Pleural Mesothelioma: Updates on Therapeutic Options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsao AS,
|
||
Pass HI,
|
||
Rimner A,
|
||
Mansfield AS</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2022 Feb 20;40(6):681-692.
|
||
Epub 2022 Jan 5
|
||
doi: 10.1200/JCO.21.01567.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34985934" target="_blank">34985934</a><a href="/pmc/articles/PMC8853621" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34551230">Perspectives on the Treatment of Malignant Pleural Mesothelioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Janes SM,
|
||
Alrifai D,
|
||
Fennell DA</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2021 Sep 23;385(13):1207-1218.
|
||
doi: 10.1056/NEJMra1912719.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34551230" target="_blank">34551230</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33485464">First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baas P,
|
||
Scherpereel A,
|
||
Nowak AK,
|
||
Fujimoto N,
|
||
Peters S,
|
||
Tsao AS,
|
||
Mansfield AS,
|
||
Popat S,
|
||
Jahan T,
|
||
Antonia S,
|
||
Oulkhouir Y,
|
||
Bautista Y,
|
||
Cornelissen R,
|
||
Greillier L,
|
||
Grossi F,
|
||
Kowalski D,
|
||
Rodríguez-Cid J,
|
||
Aanur P,
|
||
Oukessou A,
|
||
Baudelet C,
|
||
Zalcman G</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2021 Jan 30;397(10272):375-386.
|
||
Epub 2021 Jan 21
|
||
doi: 10.1016/S0140-6736(20)32714-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33485464" target="_blank">33485464</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33186182">Malignant pleural mesothelioma: recent developments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sinn K,
|
||
Mosleh B,
|
||
Hoda MA</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Oncol</span>
|
||
2021 Jan;33(1):80-86.
|
||
doi: 10.1097/CCO.0000000000000697.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33186182" target="_blank">33186182</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33012428">The Molecular Basis of Malignant Pleural Mesothelioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wadowski B,
|
||
De Rienzo A,
|
||
Bueno R</span><br />
|
||
<span class="medgenPMjournal">Thorac Surg Clin</span>
|
||
2020 Nov;30(4):383-393.
|
||
Epub 2020 Sep 12
|
||
doi: 10.1016/j.thorsurg.2020.08.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33012428" target="_blank">33012428</a><a href="/pmc/articles/PMC7536355" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesothelioma%2C%20malignant%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1104)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37104724">Pericardial Mesotheliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arrossi AV</span><br />
|
||
<span class="medgenPMjournal">Adv Anat Pathol</span>
|
||
2023 Jul 1;30(4):253-258.
|
||
Epub 2023 Apr 27
|
||
doi: 10.1097/PAP.0000000000000399.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37104724" target="_blank">37104724</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34861373">Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Popat S,
|
||
Baas P,
|
||
Faivre-Finn C,
|
||
Girard N,
|
||
Nicholson AG,
|
||
Nowak AK,
|
||
Opitz I,
|
||
Scherpereel A,
|
||
Reck M;
|
||
ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2022 Feb;33(2):129-142.
|
||
Epub 2021 Nov 30
|
||
doi: 10.1016/j.annonc.2021.11.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34861373" target="_blank">34861373</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34656227">Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fennell DA,
|
||
Ewings S,
|
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Ottensmeier C,
|
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Califano R,
|
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Hanna GG,
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Hill K,
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Danson S,
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Steele N,
|
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Nye M,
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Johnson L,
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Lord J,
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Middleton C,
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Szlosarek P,
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Chan S,
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Gaba A,
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Darlison L,
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Griffiths G;
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CONFIRM trial investigators</span><br />
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2021 Nov;22(11):1530-1540.
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Epub 2021 Oct 14
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|
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<span class="bold">PMID: </span><a href="/pubmed/34656227" target="_blank">34656227</a><a href="/pmc/articles/PMC8560642" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/33186182">Malignant pleural mesothelioma: recent developments.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Sinn K,
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Mosleh B,
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Hoda MA</span><br />
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<span class="medgenPMjournal">Curr Opin Oncol</span>
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2021 Jan;33(1):80-86.
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doi: 10.1097/CCO.0000000000000697.
|
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<span class="bold">PMID: </span><a href="/pubmed/33186182" target="_blank">33186182</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/33012430">The Staging of Malignant Pleural Mesothelioma.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Euhus CJ,
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<span class="medgenPMjournal">Thorac Surg Clin</span>
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2020 Nov;30(4):425-433.
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Epub 2020 Sep 12
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doi: 10.1016/j.thorsurg.2020.07.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33012430" target="_blank">33012430</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesothelioma%2C%20malignant%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1448)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/35940275">Malignant peritoneal mesothelioma.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Chun CP,
|
||
Song LX,
|
||
Zhang HP,
|
||
Guo DD,
|
||
Xu GX,
|
||
Li Y,
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Xin X,
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Cao J,
|
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Li F</span><br />
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<span class="medgenPMjournal">Am J Med Sci</span>
|
||
2023 Jan;365(1):99-103.
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Epub 2022 Aug 6
|
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doi: 10.1016/j.amjms.2022.07.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35940275" target="_blank">35940275</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34985934">New Era for Malignant Pleural Mesothelioma: Updates on Therapeutic Options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsao AS,
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Pass HI,
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Rimner A,
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Mansfield AS</span><br />
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<span class="medgenPMjournal">J Clin Oncol</span>
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||
2022 Feb 20;40(6):681-692.
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||
Epub 2022 Jan 5
|
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doi: 10.1200/JCO.21.01567.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34985934" target="_blank">34985934</a><a href="/pmc/articles/PMC8853621" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33186182">Malignant pleural mesothelioma: recent developments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sinn K,
|
||
Mosleh B,
|
||
Hoda MA</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Oncol</span>
|
||
2021 Jan;33(1):80-86.
|
||
doi: 10.1097/CCO.0000000000000697.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33186182" target="_blank">33186182</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29848954">Heterogeneity in Malignant Pleural Mesothelioma.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Oehl K,
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Vrugt B,
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Opitz I,
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Meerang M</span><br />
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<span class="medgenPMjournal">Int J Mol Sci</span>
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2018 May 30;19(6)
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doi: 10.3390/ijms19061603.
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<span class="bold">PMID: </span><a href="/pubmed/29848954" target="_blank">29848954</a><a href="/pmc/articles/PMC6032160" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/27997741">Advances in pleuroscopy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Anevlavis S,
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<span class="medgenPMjournal">Clin Respir J</span>
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2018 Mar;12(3):839-847.
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Epub 2017 Jan 11
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doi: 10.1111/crj.12597.
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<span class="bold">PMID: </span><a href="/pubmed/27997741" target="_blank">27997741</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesothelioma%2C%20malignant%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1025)</a></div></div>
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|
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<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/36543349">Sensitivity and complications of thoracentesis and thoracoscopy: a meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martinez-Zayas G,
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Molina S,
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Ost DE</span><br />
|
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<span class="medgenPMjournal">Eur Respir Rev</span>
|
||
2022 Dec 31;31(166)
|
||
Epub 2022 Dec 21
|
||
doi: 10.1183/16000617.0053-2022.
|
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<span class="bold">PMID: </span><a href="/pubmed/36543349" target="_blank">36543349</a><a href="/pmc/articles/PMC9879342" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33675903">Prophylactic irradiation of tracts in patients with malignant pleural mesothelioma: A systematic review and meta-analysis of randomized trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee CC,
|
||
Soon YY,
|
||
Vellayappan B,
|
||
Leong CN,
|
||
Koh WY,
|
||
Tey JCS</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
2021 Apr;160:103278.
|
||
Epub 2021 Mar 3
|
||
doi: 10.1016/j.critrevonc.2021.103278.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33675903" target="_blank">33675903</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33012427">Pathology of Malignant Pleural Mesothelioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hung YP,
|
||
Chirieac LR</span><br />
|
||
<span class="medgenPMjournal">Thorac Surg Clin</span>
|
||
2020 Nov;30(4):367-382.
|
||
doi: 10.1016/j.thorsurg.2020.08.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33012427" target="_blank">33012427</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32451346">ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scherpereel A,
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||
Opitz I,
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||
Berghmans T,
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||
Psallidas I,
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||
Glatzer M,
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||
Rigau D,
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||
Astoul P,
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||
Bölükbas S,
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Boyd J,
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Coolen J,
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De Bondt C,
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De Ruysscher D,
|
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Durieux V,
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Faivre-Finn C,
|
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Fennell D,
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Galateau-Salle F,
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Greillier L,
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Hoda MA,
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Klepetko W,
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Lacourt A,
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McElnay P,
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Maskell NA,
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Mutti L,
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Pairon JC,
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Van Schil P,
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van Meerbeeck JP,
|
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Waller D,
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Weder W,
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Cardillo G,
|
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Putora PM</span><br />
|
||
<span class="medgenPMjournal">Eur Respir J</span>
|
||
2020 Jun;55(6)
|
||
Epub 2020 Jun 11
|
||
doi: 10.1183/13993003.00953-2019.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32451346" target="_blank">32451346</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26162564">Second line therapy in malignant pleural mesothelioma: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Buikhuisen WA,
|
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Hiddinga BI,
|
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Baas P,
|
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van Meerbeeck JP</span><br />
|
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<span class="medgenPMjournal">Lung Cancer</span>
|
||
2015 Sep;89(3):223-31.
|
||
Epub 2015 Jun 23
|
||
doi: 10.1016/j.lungcan.2015.06.018.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26162564" target="_blank">26162564</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesothelioma%2C%20malignant%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0345967%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (36)</a></li>
|
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<li><a href="/gtr/tests?term=C0345967%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (2)</a></li>
|
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<li><a href="/gtr/tests?term=C0345967%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (36)</a></li>
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<li><a href="/gtr/tests?term=C0345967%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (6)</a></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22mesothelioma%2C%20malignant%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Mesothelioma%2C%20malignant%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Mesothelioma%2C+malignant/8859" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/mesothelioma_malignant" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Mesothelioma,%20malignant" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/7026/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
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