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<meta name="keywords" content="C0311335, convulsive status epilepticus, disease or syndrome, generalized convulsive status epilepticus, grand mal status epilepticus, status epilepticus, generalized convulsive, status epilepticus, grand mal, tonic-clonic status epilepticus, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A type of status epilepticus characterized by a prolonged bilateral tonic-clonic seizure, or repeated bilateral tonic-clonic seizures without recovery between." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Convulsive status epilepticus (Concept Id: C0311335)
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<!--
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Convulsive status epilepticus</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>137148</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0311335</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Generalized Convulsive Status Epilepticus; Grand Mal Status Epilepticus; Status Epilepticus, Generalized Convulsive; Status Epilepticus, Grand Mal</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0032660">HP:0032660</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A type of status epilepticus characterized by a prolonged bilateral tonic-clonic seizure, or repeated bilateral tonic-clonic seizures without recovery between. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Convulsive status epilepticus</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/311052" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Disorder">Non-Neoplastic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/317955" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Disorder by Special Category">Non-Neoplastic Disorder by Special Category</a></span><ul><li><span class="TLline"><a href="/medgen/354119" ref="tree=MeSH" title="MedGen record for Rare Non-Neoplastic Disorder">Rare Non-Neoplastic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/11586" ref="tree=MeSH" title="MedGen record for Status epilepticus">Status epilepticus</a></span><ul><li><span class="TLline"><a href="/medgen/1720011" ref="tree=MeSH" title="MedGen record for Status epilepticus with prominent motor symptoms">Status epilepticus with prominent motor symptoms</a></span><ul><li><span class="matched_ds">Convulsive status epilepticus</span><ul><li><span class="TLline"><a href="/medgen/1714035" ref="tree=MeSH" title="MedGen record for Focal-onset seizure evolving into bilateral convulsive status epilepticus">Focal-onset seizure evolving into bilateral convulsive status epilepticus</a></span></li><li><span class="TLline"><a href="/medgen/1853124" ref="tree=MeSH" title="MedGen record for Generalized convulsive status epilepticus">Generalized convulsive status epilepticus</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_332390"><div><strong>Hereditary cryohydrocytosis with reduced stomatin</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>332390</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1837206</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Stomatin-deficient cryohydrocytosis with neurologic defects (SDCHCN) is an autosomal dominant disorder characterized by delayed psychomotor development, seizures, cataracts, and pseudohyperkalemia resulting from defects in the red blood cell membrane. The disorder combines the neurologic features of Glut1 deficiency syndrome-1 (GLUT1DS1; 606777), resulting from impaired glucose transport at the blood-brain barrier, and hemolytic anemia/pseudohyperkalemia with stomatocytosis, resulting from a cation leak in erythrocytes (summary by Bawazir et al., 2012).&#13; For a discussion of clinical and genetic heterogeneity of red cell stomatocyte disorders, see 194380.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/332390">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_338393"><div><strong>Developmental and epileptic encephalopathy, 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338393</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1848137</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Developmental and epileptic encephalopathy-9 (DEE9) is an X-linked disorder characterized by seizure onset in infancy and mild to severe intellectual impairment. Autistic and psychiatric features have been reported in some individuals. The disorder affects heterozygous females only; transmitting males are unaffected (summary by Jamal et al., 2010).&#13; For a general phenotypic description and a discussion of genetic heterogeneity of developmental and epileptic encephalopathy, see 308350.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/338393">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_900333"><div><strong>Rhizomelic chondrodysplasia punctata type 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>900333</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4225237</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Rhizomelic chondrodysplasia punctata (RCDP) is a peroxisomal disorder characterized by disproportionately short stature primarily affecting the proximal parts of the extremities, a typical facial appearance including a broad nasal bridge, epicanthus, high-arched palate, dysplastic external ears, and micrognathia, congenital contractures, characteristic ocular involvement, dwarfism, and severe mental retardation with spasticity. Biochemically, plasmalogen synthesis and phytanic acid alpha-oxidation are defective. Most patients die in the first decade of life (summary by Wanders and Waterham, 2005).&#13; For a discussion of genetic heterogeneity of rhizomelic chondrodysplasia punctata, see 215100.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/900333">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_934683"><div><strong>Developmental and epileptic encephalopathy, 42</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934683</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4310716</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Developmental and epileptic encephalopathy-42 (DEE42) is a neurologic disorder characterized by the onset of various types of seizures in the first hours or days of life, although rare patients may have onset in the first weeks of life. The seizures tend to be refractory and associated with EEG abnormalities, including multifocal spikes and generalized spike-wave complexes. Affected infants show global developmental delay with severely impaired intellectual development. Other features may include axial hypotonia, peripheral hypertonia with hyperreflexia, tremor, ataxia, and abnormal eye movements (summary by the Epi4K Consortium, 2016).&#13; For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/934683">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1374886"><div><strong>Developmental and epileptic encephalopathy, 53</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1374886</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4479313</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Developmental and epileptic encephalopathy-53 (DEE53) is a severe autosomal recessive neurodegenerative disorder characterized by onset of intractable seizures in infancy. Affected individuals show hypotonia and very poor or absent global development, resulting in severe intellectual disability and spastic quadriplegia. Some patients may die in childhood (summary by Hardies et al., 2016).&#13; For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1374886">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1684874"><div><strong>Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684874</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5231491</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements (NEDHAHM) is characterized by axial hypotonia apparent from birth, global developmental delay with impaired intellectual development and poor or absent language acquisition, and behavioral abnormalities, including autistic features, poor social interaction, and hang-wringing. Most patients have childhood-onset seizures that are usually responsive to medication, and a subset of patients develop cortical visual impairment and involuntary hyperkinetic movements, including chorea and dystonia. Some of the features are reminiscent of Rett syndrome (RTT; 312750) (summary by Salpietro et al., 2019).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1684874">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1824026"><div><strong>Developmental and epileptic encephalopathy 108</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1824026</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5774253</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Developmental and epileptic encephalopathy-108 (DEE108) is characterized by the onset of multiple types of seizures in the first 2 years of life. Affected individuals often have normal early development before the onset of seizures, after which they show developmental regression with loss of skills, particularly language; most are nonverbal or speak only a few words. Other features included mildly delayed walking, unsteady gait, hypotonia, and behavioral abnormalities, such as ADHD or autism (Spinelli et al., 2021).&#13; For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1824026">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1846991"><div><strong>Developmental and epileptic encephalopathy 111</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1846991</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5882690</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Developmental and epileptic encephalopathy-111 (DEE111) is an autosomal recessive severe neurologic disorder characterized by early-onset refractory seizures, global developmental delay, hypotonia, impaired gross motor development, impaired intellectual development, and absent speech. Most patients have macrocephaly. Brain imaging shows frontal, parietal, and perisylvian polymicrogyria, dysmorphic basal ganglia and corpus callosum, and hypoplastic pons. Additional features may include feeding difficulties, poor vision with ocular anomalies, congenital cardiac abnormalities, and recurrent infections associated with neutropenia. Death in early childhood may occur (Ververi et al., 2023).&#13; For a discussion of genetic heterogeneity of DEE, see 308350.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1846991">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934683" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental and epileptic encephalopathy, 42</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1374886" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental and epileptic encephalopathy, 53</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338393" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental and epileptic encephalopathy, 9</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_332390" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary cryohydrocytosis with reduced stomatin</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684874" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_900333" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rhizomelic chondrodysplasia punctata type 5</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/35490361">International consensus on diagnosis and management of Dravet syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wirrell EC,
Hood V,
Knupp KG,
Meskis MA,
Nabbout R,
Scheffer IE,
Wilmshurst J,
Sullivan J</span><br />
<span class="medgenPMjournal">Epilepsia</span>
2022 Jul;63(7):1761-1777.
Epub 2022 May 12
doi: 10.1111/epi.17274.
<span class="bold">PMID: </span><a href="/pubmed/35490361" target="_blank">35490361</a><a href="/pmc/articles/PMC9543220" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35001380">Management of status epilepticus: a narrative review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Migdady I,
Rosenthal ES,
Cock HR</span><br />
<span class="medgenPMjournal">Anaesthesia</span>
2022 Jan;77 Suppl 1:78-91.
doi: 10.1111/anae.15606.
<span class="bold">PMID: </span><a href="/pubmed/35001380" target="_blank">35001380</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26092326">Salzburg Consensus Criteria for Non-Convulsive Status Epilepticus--approach to clinical application.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leitinger M,
Beniczky S,
Rohracher A,
Gardella E,
Kalss G,
Qerama E,
Höfler J,
Hess Lindberg-Larsen A,
Kuchukhidze G,
Dobesberger J,
Langthaler PB,
Trinka E</span><br />
<span class="medgenPMjournal">Epilepsy Behav</span>
2015 Aug;49:158-63.
Epub 2015 Jun 17
doi: 10.1016/j.yebeh.2015.05.007.
<span class="bold">PMID: </span><a href="/pubmed/26092326" target="_blank">26092326</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22convulsive%20status%20epilepticus%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (143)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/32198865">Refractory and Super-refractory Status Epilepticus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Samanta D,
Garrity L,
Arya R</span><br />
<span class="medgenPMjournal">Indian Pediatr</span>
2020 Mar 15;57(3):239-253.
doi: 10.1007/s13312-020-1759-0.
<span class="bold">PMID: </span><a href="/pubmed/32198865" target="_blank">32198865</a><a href="/pmc/articles/PMC7224023" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31722820">Medical management of status epilepticus: Emergency room to intensive care unit.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Crawshaw AA,
Cock HR</span><br />
<span class="medgenPMjournal">Seizure</span>
2020 Feb;75:145-152.
Epub 2019 Oct 24
doi: 10.1016/j.seizure.2019.10.006.
<span class="bold">PMID: </span><a href="/pubmed/31722820" target="_blank">31722820</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30916648">Non convulsive status epilepticus in the elderly.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dupont S</span><br />
<span class="medgenPMjournal">Geriatr Psychol Neuropsychiatr Vieil</span>
2019 Mar 1;17(S1):25-30.
doi: 10.1684/pnv.2019.0782.
<span class="bold">PMID: </span><a href="/pubmed/30916648" target="_blank">30916648</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29137682">Cefepime-induced neurotoxicity: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Payne LE,
Gagnon DJ,
Riker RR,
Seder DB,
Glisic EK,
Morris JG,
Fraser GL</span><br />
<span class="medgenPMjournal">Crit Care</span>
2017 Nov 14;21(1):276.
doi: 10.1186/s13054-017-1856-1.
<span class="bold">PMID: </span><a href="/pubmed/29137682" target="_blank">29137682</a><a href="/pmc/articles/PMC5686900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26092326">Salzburg Consensus Criteria for Non-Convulsive Status Epilepticus--approach to clinical application.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leitinger M,
Beniczky S,
Rohracher A,
Gardella E,
Kalss G,
Qerama E,
Höfler J,
Hess Lindberg-Larsen A,
Kuchukhidze G,
Dobesberger J,
Langthaler PB,
Trinka E</span><br />
<span class="medgenPMjournal">Epilepsy Behav</span>
2015 Aug;49:158-63.
Epub 2015 Jun 17
doi: 10.1016/j.yebeh.2015.05.007.
<span class="bold">PMID: </span><a href="/pubmed/26092326" target="_blank">26092326</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Convulsive%20status%20epilepticus%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (470)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35001380">Management of status epilepticus: a narrative review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Migdady I,
Rosenthal ES,
Cock HR</span><br />
<span class="medgenPMjournal">Anaesthesia</span>
2022 Jan;77 Suppl 1:78-91.
doi: 10.1111/anae.15606.
<span class="bold">PMID: </span><a href="/pubmed/35001380" target="_blank">35001380</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30170734">Pathophysiology of convulsive status epilepticus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sánchez Fernández I,
Goodkin HP,
Scott RC</span><br />
<span class="medgenPMjournal">Seizure</span>
2019 May;68:16-21.
Epub 2018 Aug 6
doi: 10.1016/j.seizure.2018.08.002.
<span class="bold">PMID: </span><a href="/pubmed/30170734" target="_blank">30170734</a><a href="/pmc/articles/PMC6506391" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29137682">Cefepime-induced neurotoxicity: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Payne LE,
Gagnon DJ,
Riker RR,
Seder DB,
Glisic EK,
Morris JG,
Fraser GL</span><br />
<span class="medgenPMjournal">Crit Care</span>
2017 Nov 14;21(1):276.
doi: 10.1186/s13054-017-1856-1.
<span class="bold">PMID: </span><a href="/pubmed/29137682" target="_blank">29137682</a><a href="/pmc/articles/PMC5686900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26092326">Salzburg Consensus Criteria for Non-Convulsive Status Epilepticus--approach to clinical application.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leitinger M,
Beniczky S,
Rohracher A,
Gardella E,
Kalss G,
Qerama E,
Höfler J,
Hess Lindberg-Larsen A,
Kuchukhidze G,
Dobesberger J,
Langthaler PB,
Trinka E</span><br />
<span class="medgenPMjournal">Epilepsy Behav</span>
2015 Aug;49:158-63.
Epub 2015 Jun 17
doi: 10.1016/j.yebeh.2015.05.007.
<span class="bold">PMID: </span><a href="/pubmed/26092326" target="_blank">26092326</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25908090">Status epilepticus in adults.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Betjemann JP,
Lowenstein DH</span><br />
<span class="medgenPMjournal">Lancet Neurol</span>
2015 Jun;14(6):615-24.
Epub 2015 Apr 20
doi: 10.1016/S1474-4422(15)00042-3.
<span class="bold">PMID: </span><a href="/pubmed/25908090" target="_blank">25908090</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Convulsive%20status%20epilepticus%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (544)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/35001380">Management of status epilepticus: a narrative review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Migdady I,
Rosenthal ES,
Cock HR</span><br />
<span class="medgenPMjournal">Anaesthesia</span>
2022 Jan;77 Suppl 1:78-91.
doi: 10.1111/anae.15606.
<span class="bold">PMID: </span><a href="/pubmed/35001380" target="_blank">35001380</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31774955">Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kapur J,
Elm J,
Chamberlain JM,
Barsan W,
Cloyd J,
Lowenstein D,
Shinnar S,
Conwit R,
Meinzer C,
Cock H,
Fountain N,
Connor JT,
Silbergleit R;
NETT and PECARN Investigators</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2019 Nov 28;381(22):2103-2113.
doi: 10.1056/NEJMoa1905795.
<span class="bold">PMID: </span><a href="/pubmed/31774955" target="_blank">31774955</a><a href="/pmc/articles/PMC7098487" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30170734">Pathophysiology of convulsive status epilepticus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sánchez Fernández I,
Goodkin HP,
Scott RC</span><br />
<span class="medgenPMjournal">Seizure</span>
2019 May;68:16-21.
Epub 2018 Aug 6
doi: 10.1016/j.seizure.2018.08.002.
<span class="bold">PMID: </span><a href="/pubmed/30170734" target="_blank">30170734</a><a href="/pmc/articles/PMC6506391" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29137682">Cefepime-induced neurotoxicity: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Payne LE,
Gagnon DJ,
Riker RR,
Seder DB,
Glisic EK,
Morris JG,
Fraser GL</span><br />
<span class="medgenPMjournal">Crit Care</span>
2017 Nov 14;21(1):276.
doi: 10.1186/s13054-017-1856-1.
<span class="bold">PMID: </span><a href="/pubmed/29137682" target="_blank">29137682</a><a href="/pmc/articles/PMC5686900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25908090">Status epilepticus in adults.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Betjemann JP,
Lowenstein DH</span><br />
<span class="medgenPMjournal">Lancet Neurol</span>
2015 Jun;14(6):615-24.
Epub 2015 Apr 20
doi: 10.1016/S1474-4422(15)00042-3.
<span class="bold">PMID: </span><a href="/pubmed/25908090" target="_blank">25908090</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Convulsive%20status%20epilepticus%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (524)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35333156">Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cruickshank M,
Imamura M,
Booth C,
Aucott L,
Counsell C,
Manson P,
Scotland G,
Brazzelli M</span><br />
<span class="medgenPMjournal">Health Technol Assess</span>
2022 Mar;26(20):1-76.
doi: 10.3310/RSVK2062.
<span class="bold">PMID: </span><a href="/pubmed/35333156" target="_blank">35333156</a><a href="/pmc/articles/PMC8977974" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35001380">Management of status epilepticus: a narrative review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Migdady I,
Rosenthal ES,
Cock HR</span><br />
<span class="medgenPMjournal">Anaesthesia</span>
2022 Jan;77 Suppl 1:78-91.
doi: 10.1111/anae.15606.
<span class="bold">PMID: </span><a href="/pubmed/35001380" target="_blank">35001380</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30916648">Non convulsive status epilepticus in the elderly.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dupont S</span><br />
<span class="medgenPMjournal">Geriatr Psychol Neuropsychiatr Vieil</span>
2019 Mar 1;17(S1):25-30.
doi: 10.1684/pnv.2019.0782.
<span class="bold">PMID: </span><a href="/pubmed/30916648" target="_blank">30916648</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29137682">Cefepime-induced neurotoxicity: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Payne LE,
Gagnon DJ,
Riker RR,
Seder DB,
Glisic EK,
Morris JG,
Fraser GL</span><br />
<span class="medgenPMjournal">Crit Care</span>
2017 Nov 14;21(1):276.
doi: 10.1186/s13054-017-1856-1.
<span class="bold">PMID: </span><a href="/pubmed/29137682" target="_blank">29137682</a><a href="/pmc/articles/PMC5686900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24767707">Diagnosis of reversible causes of coma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Edlow JA,
Rabinstein A,
Traub SJ,
Wijdicks EF</span><br />
<span class="medgenPMjournal">Lancet</span>
2014 Dec 6;384(9959):2064-76.
Epub 2014 Apr 21
doi: 10.1016/S0140-6736(13)62184-4.
<span class="bold">PMID: </span><a href="/pubmed/24767707" target="_blank">24767707</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Convulsive%20status%20epilepticus%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (328)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/36750385">Rates of Status Epilepticus and Sudden Unexplained Death in Epilepsy in People With Genetic Developmental and Epileptic Encephalopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Donnan AM,
Schneider AL,
Russ-Hall S,
Churilov L,
Scheffer IE</span><br />
<span class="medgenPMjournal">Neurology</span>
2023 Apr 18;100(16):e1712-e1722.
Epub 2023 Feb 7
doi: 10.1212/WNL.0000000000207080.
<span class="bold">PMID: </span><a href="/pubmed/36750385" target="_blank">36750385</a><a href="/pmc/articles/PMC10115508" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35333156">Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cruickshank M,
Imamura M,
Booth C,
Aucott L,
Counsell C,
Manson P,
Scotland G,
Brazzelli M</span><br />
<span class="medgenPMjournal">Health Technol Assess</span>
2022 Mar;26(20):1-76.
doi: 10.3310/RSVK2062.
<span class="bold">PMID: </span><a href="/pubmed/35333156" target="_blank">35333156</a><a href="/pmc/articles/PMC8977974" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29320603">Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McTague A,
Martland T,
Appleton R</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2018 Jan 10;1(1):CD001905.
doi: 10.1002/14651858.CD001905.pub3.
<span class="bold">PMID: </span><a href="/pubmed/29320603" target="_blank">29320603</a><a href="/pmc/articles/PMC6491279" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27571157">Diagnostic accuracy of the Salzburg EEG criteria for non-convulsive status epilepticus: a retrospective study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leitinger M,
Trinka E,
Gardella E,
Rohracher A,
Kalss G,
Qerama E,
Höfler J,
Hess A,
Zimmermann G,
Kuchukhidze G,
Dobesberger J,
Langthaler PB,
Beniczky S</span><br />
<span class="medgenPMjournal">Lancet Neurol</span>
2016 Sep;15(10):1054-62.
Epub 2016 Aug 8
doi: 10.1016/S1474-4422(16)30137-5.
<span class="bold">PMID: </span><a href="/pubmed/27571157" target="_blank">27571157</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26092326">Salzburg Consensus Criteria for Non-Convulsive Status Epilepticus--approach to clinical application.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leitinger M,
Beniczky S,
Rohracher A,
Gardella E,
Kalss G,
Qerama E,
Höfler J,
Hess Lindberg-Larsen A,
Kuchukhidze G,
Dobesberger J,
Langthaler PB,
Trinka E</span><br />
<span class="medgenPMjournal">Epilepsy Behav</span>
2015 Aug;49:158-63.
Epub 2015 Jun 17
doi: 10.1016/j.yebeh.2015.05.007.
<span class="bold">PMID: </span><a href="/pubmed/26092326" target="_blank">26092326</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Convulsive%20status%20epilepticus%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (272)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/36833226">Status Epilepticus in Chromosomal Disorders Associated with Epilepsy: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bergonzini L,
Pruccoli J,
Pettenuzzo I,
Pugliano R,
Soliani L,
Fetta A,
Cordelli DM</span><br />
<span class="medgenPMjournal">Genes (Basel)</span>
2023 Jan 23;14(2)
doi: 10.3390/genes14020299.
<span class="bold">PMID: </span><a href="/pubmed/36833226" target="_blank">36833226</a><a href="/pmc/articles/PMC9956098" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35333156">Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cruickshank M,
Imamura M,
Booth C,
Aucott L,
Counsell C,
Manson P,
Scotland G,
Brazzelli M</span><br />
<span class="medgenPMjournal">Health Technol Assess</span>
2022 Mar;26(20):1-76.
doi: 10.3310/RSVK2062.
<span class="bold">PMID: </span><a href="/pubmed/35333156" target="_blank">35333156</a><a href="/pmc/articles/PMC8977974" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31931342">Prevalence and clinical correlates of non-convulsive status epilepticus in elderly patients with acute confusional state: A systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Manfredonia F,
Saturno E,
Lawley A,
Gasverde S,
Cavanna AE</span><br />
<span class="medgenPMjournal">J Neurol Sci</span>
2020 Mar 15;410:116674.
Epub 2020 Jan 7
doi: 10.1016/j.jns.2020.116674.
<span class="bold">PMID: </span><a href="/pubmed/31931342" target="_blank">31931342</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29320603">Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McTague A,
Martland T,
Appleton R</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2018 Jan 10;1(1):CD001905.
doi: 10.1002/14651858.CD001905.pub3.
<span class="bold">PMID: </span><a href="/pubmed/29320603" target="_blank">29320603</a><a href="/pmc/articles/PMC6491279" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29137682">Cefepime-induced neurotoxicity: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Payne LE,
Gagnon DJ,
Riker RR,
Seder DB,
Glisic EK,
Morris JG,
Fraser GL</span><br />
<span class="medgenPMjournal">Crit Care</span>
2017 Nov 14;21(1):276.
doi: 10.1186/s13054-017-1856-1.
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Convulsive%20status%20epilepticus%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (31)</a></div></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22convulsive%20status%20epilepticus%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Convulsive%20status%20epilepticus%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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